C. Sadasivan

发表

A profile of protein-protein interaction: Crystal structure of a lectin-lectin complex.

S. Surya, J. Abhilash, K. Geethanandan, 2016, International journal of biological macromolecules.

Kam Y. J. Zhang, R. V. Omkumar, C. Sadasivan, 2021, International journal of biological macromolecules.

Interaction of the factor XIII activation peptide with alpha -thrombin. Crystal structure of its enzyme-substrate analog complex.

C. Sadasivan, V. Yee, 2000, The Journal of biological chemistry.

Neuroprotective derivatives of tacrine that target NMDA receptor and acetyl cholinesterase - Design, synthesis and biological evaluation

Kam Y. J. Zhang, R. V. Omkumar, C. Sadasivan, 2021, bioRxiv.

Functionalised dihydroazo pyrimidine derivatives from Morita–Baylis–Hillman acetates: synthesis and studies against acetylcholinesterase as its inhibitors

C. Sadasivan, S. Anwar, C. Remya, 2016 .

Modeling of Factor XIII Activation Peptide (28–41) V34L Mutant Bound To Thrombin

C. Sadasivan, D. Nair, P. Sunilkumar, 2008, Journal of biomolecular structure & dynamics.

Computational and experimental validation of morin as adenosine deaminase inhibitor

C. Sadasivan, K. G. Arun, C. S. Sharanya, 2018, Journal of receptor and signal transduction research.

Design of potent inhibitors of acetylcholinesterase using morin as the starting compound

C. Sadasivan, C. Remya, K. V. Dileep, 2012 .

Novel tacrine derivatives exhibiting improved acetylcholinesterase inhibition: Design, synthesis and biological evaluation.

R. V. Omkumar, C. Sadasivan, S. Anwar, 2017, European journal of medicinal chemistry.

Trichoderma viride Laccase Plays a Crucial Role in Defense Mechanism against Antagonistic Organisms

C. Sadasivan, A. Castle, L. Divya, 2016, Front. Microbiol..

An Isoquinoline Alkaloid, Berberine, Can Inhibit Fungal Alpha Amylase: Enzyme Kinetic and Molecular Modeling Studies

C. Sadasivan, K. V. Dileep, I. Tintu, 2012, Chemical biology & drug design.

Selective Estrogen Receptor Modulators (SERMs) from Plants

C. Sadasivan, Divya Lakshmanan Mangalath, 2015 .

Cuminaldehyde as a Lipoxygenase Inhibitor: In Vitro and In Silico Validation

C. Sadasivan, M. Haridas, K. V. Dileep, 2014, Applied Biochemistry and Biotechnology.

X-ray structure of a galactose-specific lectin from Spatholobous parviflorous.

J. Abhilash, K. Geethanandan, C. Sadasivan, 2011, International journal of biological macromolecules.

Inhibitory activity of IAA and IBA against lipoxygenase: in silico and in vitro validation

C. Sadasivan, C. Remya, K. V. Dileep, 2014 .

Studies of IAA and IBA as fungal α-amylase inhibitors using enzyme kinetics, molecular modeling and thermodynamics†

C. Sadasivan, C. Remya, K. V. Dileep, 2012 .

Binding of rosmarinic acid curcumin and capsaicin with PLA2: A comparative study.

C. Sadasivan, C. Remya, K. V. Dileep, 2022, Biochemical and biophysical research communications.

Interactions of selected indole derivatives with phospholipase A2: in silico and in vitro analysis

C. Sadasivan, C. Remya, K. V. Dileep, 2013, Journal of Molecular Modeling.

An in silico approach for the identification of inhibitors against Acetylcholinesterase

C. Sadasivan, C. Remya, K. V. Dileep, 2012, Medicinal Chemistry Research.

Molecular docking studies of curcumin analogs with phospholipase A2

C. Sadasivan, K. V. Dileep, I. Tintu, 2011, Interdisciplinary Sciences: Computational Life Sciences.

Indole fragments for the design of lead molecules against pancreatitis

C. Sadasivan, H. Pérez‐Sánchez, C. Remya, 2020, Journal of biomolecular structure & dynamics.

Neuroprotective derivatives of tacrine that target NMDA receptor and acetyl cholinesterase – Design, synthesis and biological evaluation

Kam Y. J. Zhang, R. V. Omkumar, C. Sadasivan, 2021, Computational and structural biotechnology journal.

Anti‐Inflammatory Property of n‐Hexadecanoic Acid: Structural Evidence and Kinetic Assessment

C. Sadasivan, K. V. Dileep, P. Karthe, 2012, Chemical biology & drug design.

Gallic acid binding to Spatholobus parviflorus lectin provides insight to its quaternary structure forming.

S. Surya, K. Geethanandan, C. Sadasivan, 2016, International journal of biological macromolecules.

Inhibition of Beta-Lactamase by 1,4-Naphthalenedione from the Plant Holoptelea integrifolia

C. Sadasivan, K. V. Dileep, N. Vinod, 2010, Applied biochemistry and biotechnology.

Molecular structure of Lantadene-BC Lantadene-C, 22 β-(S)-2′-methyl butanoyloxy-3-oxoolean-12-en-28-oic acid

C. Sadasivan, V. Pattabhi, O. Sharma, 1993 .

Molecular structure of Lantadene-B&C, triterpenoids ofantana camara, red variety: Lantadene-B, 22β-angeloyloxy-3-oxoolean-12-en-28-oic acid; Lantadene-C, 22 β-(S)-2′-methyl butanoyloxy-3-oxoolean-12-en-28-oic acid

C. Sadasivan, V. Pattabhi, O. Sharma, 1993 .

Lipoxygenase inhibitory activity of some Sida species due to di ( 2-ethylhexyl ) phthalate

C. Sadasivan, M. Haridas, D. S. Preethidan, 2013 .

Flavanone Glycosides as Acetylcholinesterase Inhibitors: Computational and Experimental Evidence

C. Sadasivan, C. Remya, K. V. Dileep, 2014, Indian journal of pharmaceutical sciences.

Derivatives Form Better Lipoxygenase Inhibitors than Piperine: In Vitro and In Silico Study

C. Sadasivan, K. V. Dileep, M. Haridas, 2015, Chemical biology & drug design.

A Lectin from Spatholobus parviflorus Inhibits Aspergillus flavus α‐Amylase: Enzyme Kinetics and Thermodynamic Studies

J. Abhilash, C. Sadasivan, K. V. Dileep, 2014, Chemical biology & drug design.

6‐Gingerol inhibits fungal alpha amylase: Enzyme kinetic and molecular modeling studies

C. Sadasivan, C. Remya, K. V. Dileep, 2012 .

Repurposing of Streptomyces antibiotics as adenosine deaminase inhibitors by pharmacophore modeling, docking, molecular dynamics, and in vitro studies

C. Sadasivan, K. G. Arun, J. Abhithaj, 2020, Journal of receptor and signal transduction research.

Biochemical and computational insights of adenosine deaminase inhibition by Epigallocatechin gallate

G. ArunK., S. SharanyaC., J. Abhithaj, 2019, Comput. Biol. Chem..

Inhibitory activity of hibifolin on adenosine deaminase- experimental and molecular modeling study

G. Arun Kumar, C. Sharanya Suresh, P. M. Sandeep, 2016, Comput. Biol. Chem..

Targeting Thymidylate Synthase Enhances the Chemosensitivity of Triple-Negative Breast Cancer Towards 5-FU-Based Combinatorial Therapy

C. Sadasivan, A. Nawab, R. J. Anto, 2021, Frontiers in Oncology.

Gossypin as a Novel Selective Dual Inhibitor of v-raf Murine Sarcoma Viral Oncogene Homolog B1 and Cyclin-Dependent Kinase 4 for Melanoma

C. Sadasivan, R. Tekmal, J. VandeBerg, 2013, Molecular Cancer Therapeutics.

In silico screening for identification of fatty acid synthase inhibitors and evaluation of their antiproliferative activity using human cancer cell lines

C. Sadasivan, R. J. Anto, A. Retnakumari, 2018, Journal of receptor and signal transduction research.

Pyridine derivatives as anticancer lead compounds with Fatty Acid Synthase as the target: An in silico‐guided in vitro study

C. Sadasivan, R. J. Anto, Nisthul A. Amrutha, 2019, Journal of cellular biochemistry.

Bisphenol-A carbonate dimer is a more preferred substrate for laccase mediated degradation than the Biphenol-A in its monomeric and dimeric forms

C. Sadasivan, G. Prasanth, L. Divya, 2018, International Biodeterioration & Biodegradation.

TRAIL-based tumor sensitizing galactoxyloglucan, a novel entity for targeting apoptotic machinery.

Manu M. Joseph, P. Balaram, C. Sadasivan, 2015, The international journal of biochemistry & cell biology.

Cellular calcium signaling in the aging brain

R. V. Omkumar, C. Sadasivan, R. Chandran, 2017, Journal of Chemical Neuroanatomy.

Inhibition, ADME and structure based modification of IAA and IBA against acetylcholinesterase: an attempt towards new drug development for Alzheimer's disease

C. Sadasivan, C. Remya, K. V. Dileep, 2013 .

In vitro inhibitory profile of NDGA against AChE and its in silico structural modifications based on ADME profile

C. Sadasivan, C. Remya, K. V. Dileep, 2013, Journal of Molecular Modeling.

Role of invariant water molecules in retaining the active site geometry of β-lactamase: a molecular dynamics simulation study

C. Sadasivan, K. V. Dileep, I. Tintu, 2011 .

Designing of multi-target-directed ligands against the enzymes associated with neuroinflammation: an in silico approach

C. Sadasivan, C. Remya, K. V. Dileep, 2013 .

Comparative studies on the inhibitory activities of selected benzoic acid derivatives against secretory phospholipase A2, a key enzyme involved in the inflammatory pathway.

A. Fassihi, C. Sadasivan, H. Pérez‐Sánchez, 2015, Molecular bioSystems.

An in silico guided identification of nAChR agonists from Withania somnifera

C. Sadasivan, C. Remya, K. V. Dileep, 2016 .

Binding to PLA2 May Contribute to the Anti‐Inflammatory Activity of Catechol

C. Sadasivan, K. V. Dileep, P. Karthe, 2012, Chemical biology & drug design.

Plasticity, hydration and accessibility in ribonuclease A. The structure of a new crystal form and its low-humidity variant.

H. G. Nagendra, M. Vijayan, C. Sadasivan, 1998, Acta crystallographica. Section D, Biological crystallography.

Binding of NDGA and morin with phospholipase A2: experimental and computational evidences

C. Sadasivan, C. Remya, K. V. Dileep, 2015 .

Interactions of selected indole derivatives with COX-2 and their in silico structure modifications towards the development of novel NSAIDs

C. Sadasivan, C. Remya, K. V. Dileep, 2014, Journal of biomolecular structure & dynamics.

Drug repurposing against SARS-CoV-2 using E-pharmacophore based virtual screening, molecular docking and molecular dynamics with main protease as the target

J. Abhithaj, C. Sadasivan, C. Sadasivan, 2020, Journal of biomolecular structure & dynamics.

Evaluation of biotransformed berberine derivatives as anti inflammatory drugs: An in silico study

C. Sadasivan, M. Haridas, G. Prasanth, 2012, Interdisciplinary Sciences: Computational Life Sciences.

Inverted binding due to a minor structural change in berberine enhances its phospholipase A2 inhibitory effect.

J. Abhilash, C. Sadasivan, M. Haridas, 2012, International journal of biological macromolecules.

Identification of a novel and potent inhibitor of phospholipase A(2) in a medicinal plant: crystal structure at 1.93Å and Surface Plasmon Resonance analysis of phospholipase A(2) complexed with berberine.

T. Singh, C. Sadasivan, Sanjit Kumar, 2011, Biochimica et biophysica acta.

Sequence-dependent microheterogeneity of Z-DNA: the crystal and molecular structures of d(CACGCG).d(CGCGTG) and d(CGCACG).d(CGTGCG).

C. Sadasivan, N. Gautham, 1995, Journal of molecular biology.

Crystal structure of porcine pancreatic phospholipase A2 in complex with 2-methoxycyclohexa-2-5-diene-1,4-dione

C. Sadasivan, K. V. Dileep, P. Karthe, 2009 .

Packing interactions of crystallographically independent molecules in organic crystals

C. Sadasivan, N. Gautham, P. Karthe, 1993 .

Crystallization and preliminary X-ray studies of a galactose-specific lectin from the seeds of Spatholobus parviflorus.

J. Abhilash, K. Geethanandan, C. Sadasivan, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

Virtual screening-based identification of novel fatty acid synthase inhibitor and evaluation of its antiproliferative activity in breast cancer cells.

C. Sadasivan, R. J. Anto, P. Archana, 2021, Journal of molecular graphics & modelling.

Computational and thermodynamic analyses of the phospholipase A2 inhibition by erucic acid and linoleic acid

C. Sadasivan, K. V. Dileep, M. Haridas, 2013, Medicinal Chemistry Research.

Lobeline: A multifunctional alkaloid modulates cholinergic and glutamatergic activities

R. V. Omkumar, C. Sadasivan, C. Remya, 2023, IUBMB life.

Bisphenol‐A can bind to human glucocorticoid receptor as an agonist: an in silico study

C. Sadasivan, G. Prasanth, L. Divya, 2010, Journal of applied toxicology : JAT.

Trypsin is inhibited by phytocompounds liquiritin and terpinen-4-ol from the herb Glycyrrhiza glabra: in vitro and in silico studies

C. Sadasivan, K. G. Arun, J. Abhithaj, 2023, Journal of biomolecular structure & dynamics.

Crystallization and preliminary X-ray diffraction analysis of a galactose-specific lectin from the seeds of Butea monosperma.

J. Abhilash, K. Geethanandan, C. Sadasivan, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

Anti‐Inflammatory Property of n‐Hexadecanoic Acid: Structural Evidence and Kinetic Assessment

C. Sadasivan, K. V. Dileep, P. Karthe, 2012, Chemical biology & drug design.

Antibacterial Action of Leaves of Aegle Marmelos

C. Sadasivan, Toji Thomas, Rijamol K. Ulahannan, 2008 .

Binding to PLA2 May Contribute to the Anti‐Inflammatory Activity of Catechol

C. Sadasivan, K. V. Dileep, P. Karthe, 2012, Chemical biology & drug design.

Bisphenol‐A can bind to human glucocorticoid receptor as an agonist: an in silico study

C. Sadasivan, G. Prasanth, L. M. Divya, 2010, Journal of applied toxicology : JAT.

Unveiling the molecular basis of lobeline's allosteric regulation of NMDAR: insights from molecular modeling

C. Sadasivan, C. Remya, K. V. Dileep, 2023, Scientific reports.

Crystal structure of phospholipase A2 in complex with 1‐naphthaleneacetic acid

C. Sadasivan, C. Remya, K. V. Dileep, 2018, IUBMB life.