Eunhwa Ko

发表

Minimalist and universal peptidomimetics.

Kevin Burgess, Jing Liu, Eunhwa Ko, 2011, Chemical Society reviews.

In glaucoma the upregulated truncated TrkC.T1 receptor isoform in glia causes increased TNF-alpha production, leading to retinal ganglion cell death.

L. Tessarollo, Eunhwa Ko, Jing Liu, 2010, Investigative ophthalmology & visual science.

Catalytic in vivo protein knockdown by small-molecule PROTACs.

I. E. Smith, Marcus Bantscheff, Kristoffer Famm, 2015, Nature chemical biology.

Suppression of the metastatic spread of breast cancer by DN10764 (AZD7762)-mediated inhibition of AXL signaling

H. Choi, Eunhwa Ko, Joon-Suk Park, 2016, Oncotarget.

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL.

Eunhwa Ko, C. Crews, Ashton C Lai, 2016, Angewandte Chemie.

Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors.

Eunhwa Ko, Ji Hoon Lee, Ji-Eun Lee, 2017, Journal of medicinal chemistry.

Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation.

Philipp M. Cromm, Eunhwa Ko, C. Crews, 2017, ACS chemical biology.

A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader.

Dennis L. Buckley, J. Bradner, N. Gray, 2017, Cell chemical biology.

FRTX-02, a selective and potent inhibitor of DYRK1A, modulates inflammatory pathways in mouse models of psoriasis and atopic dermatitis

H. Choi, Eunhwa Ko, B. Khor, 2022, Journal of translational autoimmunity.

Pyrrolinone-pyrrolidine oligomers as universal peptidomimetics.

T. Ioerger, Eunhwa Ko, K. Burgess, 2011, Journal of the American Chemical Society.

Pyrrole-based scaffolds for turn mimics.

Eunhwa Ko, K. Burgess, 2011, Organic letters.

Universal peptidomimetics.

Eunhwa Ko, Jing Liu, K. Burgess, 2011, Journal of the American Chemical Society.

Omegatides: constrained analogs of peptide primary sequence.

Eunhwa Ko, K. Burgess, D. Fedoseyenko, 2012, Organic & biomolecular chemistry.

Exploring key orientations at protein-protein interfaces with small molecule probes.

Kevin Burgess, Thomas R Ioerger, T. Ioerger, 2013, Journal of the American Chemical Society.

The small molecule CA140 inhibits the neuroinflammatory response in wild-type mice and a mouse model of AD

H. Choi, Eunhwa Ko, Jerry Yang, 2018, Journal of Neuroinflammation.

Small Molecule Ligands For Active Targeting Of TrkC-expressing Tumor Cells.

Eunhwa Ko, K. Burgess, A. Kamkaew, 2012, ACS medicinal chemistry letters.

The small molecule CA140 inhibits the neuroinflammatory response in wild-type mice and a mouse model of AD

H. Choi, Eunhwa Ko, Jerry Yang, 2018, Journal of Neuroinflammation.

Brain injury induces HIF-1α-dependent transcriptional activation of LRRK2 that exacerbates brain damage

H. Choi, E. Hur, Eunhwa Ko, 2018, Cell Death & Disease.

X-ray Crystal Structure-Guided Design and Optimization of 7H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor.

H. Choi, Haelee Kim, Eunhwa Ko, 2021, Journal of medicinal chemistry.

Evaluating minimalist mimics by exploring key orientations on secondary structures (EKOS).

T. Ioerger, Eunhwa Ko, K. Burgess, 2013, Organic & biomolecular chemistry.

Combinatorial Assembly of Small Molecules into Bivalent Antagonists of TrkC or TrkA Receptors

Eunhwa Ko, K. Burgess, A. Malakhov, 2014, PloS one.

Brain injury induces HIF-1α-dependent transcriptional activation of LRRK2 that exacerbates brain damage

H. Choi, E. Hur, Eunhwa Ko, 2018, Cell Death & Disease.