D. Ogg

发表

Structural basis of pilus subunit recognition by the PapD chaperone.

T. Bergfors, S. Hultgren, M. Kuehn, 1993, Science.

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use

C. Orengo, A. Breeze, P. Ashford, 2016, Oncotarget.

Structure-based design and pharmacokinetic optimization of covalent allosteric inhibitors of the mutant GTPase KRASG12C.

Doyle J Cassar, J. Breed, D. Ogg, 2020, Journal of medicinal chemistry.

Protein-ligand crystal structures can guide the design of selective inhibitors of the FGFR tyrosine kinase.

Andrew G. Leach, J. Breed, D. M. Andrews, 2012, Journal of medicinal chemistry.

Investigation of potential bioisosteric replacements for the carboxyl groups of peptidomimetic inhibitors of protein tyrosine phosphatase 1B: identification of a tetrazole-containing inhibitor with cellular activity.

D. Ogg, S. Larsen, J. E. Bleasdale, 2002, Journal of medicinal chemistry.

Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.

Rhys D O Jones, S. Guichard, W. Shao, 2018, Journal of medicinal chemistry.

Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors.

David M. Robinson, M. Waring, D. Ogg, 2020, Journal of the American Chemical Society.

Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site

S. Steinbacher, M. Augustin, D. Ogg, 2016, Acta crystallographica. Section D, Structural biology.

Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B

A. Barr, K. Fütterer, S. Pollack, 2019, bioRxiv.

Crystallization and preliminary X-ray diffraction studies of a new crystal form of human secretory type IIA phospholipase A2.

D. Ogg, W. B. Church, K. Scott, 2000, Acta crystallographica. Section D, Biological crystallography.

Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology.

S. Kazmirski, Nancy Su, D. Ogg, 2015, ACS medicinal chemistry letters.

Identification and optimisation of 3,3-dimethyl-azetidin-2-ones as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)

S. Steinbacher, M. Augustin, D. Ogg, 2014 .

Structure of human semicarbazide-sensitive amine oxidase/vascular adhesion protein-1.

G. Kleywegt, D. Ogg, J. Nilsson, 2005, Acta crystallographica. Section D, Biological crystallography.

The structure of the PP2A regulatory subunit B56γ: The remaining piece of the PP2A jigsaw puzzle

P. Nordlund, S. Gräslund, D. Ogg, 2009, Proteins.

The structure of human collapsin response mediator protein 2, a regulator of axonal growth

P. Nordlund, D. Ogg, P. Kursula, 2007, Journal of neurochemistry.

The structure of mouse L1210 dihydrofolate reductase‐drug complexes and the construction of a model of human enzyme

C. Beddell, J. Champness, D. Stammers, 1987, FEBS letters.

Novel acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329).

Martin J Packer, Nidhal Selmi, Andrew Stocker, 2012, Journal of medicinal chemistry.

Thiazolopyridone ureas as DNA gyrase B inhibitors: optimization of antitubercular activity and efficacy.

Vijay T. Ahuja, D. Ogg, P. Boriack-Sjodin, 2014, Bioorganic & medicinal chemistry letters.

Thiazolopyridine ureas as novel antitubercular agents acting through inhibition of DNA Gyrase B.

Vijay T. Ahuja, D. Ogg, J. Tucker, 2013, Journal of medicinal chemistry.

Potent and selective bivalent inhibitors of BET bromodomains.

A. Dulak, A. Rabow, M. Waring, 2016, Nature chemical biology.

Heparan sulfates are critical regulators of the inhibitory 1 megakaryocyte-platelet receptor G 6 b-B 2 3

A. Barr, K. Fütterer, S. Pollack, 2022 .

Crystallization of a truncated soluble human semicarbazide-sensitive amine oxidase.

G. Kleywegt, D. Ogg, J. Nilsson, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode

S. P. Andrews, J. Duce, H. Willems, 2022, Journal of medicinal chemistry.

Crystal structure of the heterodimeric complex of LXRα and RXRβ ligand‐binding domains in a fully agonistic conformation

Stefan Svensson, Micael Jacobsson, L. Jendeberg, 2003, The EMBO journal.

Discovery of a potent, selective, and orally bioavailable acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017).

Martin J Packer, Nidhal Selmi, David Hargreaves, 2012, Journal of medicinal chemistry.

Predicting the relative binding affinity of mineralocorticoid receptor antagonists by density functional methods

Anders Hogner, Eva Hansson, Martin J. Packer, 2015, Journal of Computer-Aided Molecular Design.

The Crystal Structure of Guinea Pig 11β-Hydroxysteroid Dehydrogenase Type 1 Provides a Model for Enzyme-Lipid Bilayer Interactions*

L. Abrahmsén, U. Oppermann, D. Ogg, 2005, Journal of Biological Chemistry.

Variation of Enzyme and Cellular Potency with Substituents R 1 , R 2 , and R 3 As Indicated

Andrew G. Leach, J. Breed, D. M. Andrews, 2012 .

Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action.

X Y Wang, M. Swanson, D. Ogg, 2001, Biochemistry.

Synthesis and biological activity of a novel class of small molecular weight peptidomimetic competitive inhibitors of protein tyrosine phosphatase 1B.

D. Ogg, P. D. May, S. Larsen, 2002, Journal of medicinal chemistry.

D. Hargreaves, D. Ogg, James S. Scott, 2012, Journal of medicinal chemistry.

Periplasmic chaperone recognition motif of subunits mediates quaternary interactions in the pilus

S. Hultgren, S. Knight, K. Dodson, 1998, The EMBO journal.