J. Kihlberg

发表

Structural basis of pilus subunit recognition by the PapD chaperone.

T. Bergfors, S. Hultgren, M. Kuehn, 1993, Science.

Macrocyclic drugs and clinical candidates: what can medicinal chemists learn from their properties?

Fabrizio Giordanetto, Jan Kihlberg, J. Kihlberg, 2014, Journal of medicinal chemistry.

Oral druggable space beyond the rule of 5: insights from drugs and clinical candidates.

Fabrizio Giordanetto, Jan Kihlberg, J. Kihlberg, 2014, Chemistry & biology.

How Beyond Rule of 5 Drugs and Clinical Candidates Bind to Their Targets.

Bradley C Doak, Jan Kihlberg, J. Kihlberg, 2016, Journal of medicinal chemistry.

Integrative approaches in HIV‐1 non‐nucleoside reverse transcriptase inhibitor design

Vasanthanathan Poongavanam, N. A. Murugan, J. Kihlberg, 2018 .

Conformation of the Macrocyclic Drug Lorlatinib in Polar and Nonpolar Environments: A MD Simulation and NMR Study

Jiye Shi, Weiliang Zhu, Zhijian Xu, 2019, ACS omega.

Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Richard Svensson, Giovanni Muncipinto, Fabrizio Giordanetto, 2014, Journal of medicinal chemistry.

Cell permeability beyond the rule of 5.

Bradley C Doak, Jan Kihlberg, Pär Matsson, 2016, Advanced drug delivery reviews.

Transferred nuclear Overhauser effect spectroscopy study of a peptide from the PapG pilus subunit bound by the Escherichia coli PapD chaperone

J. Pinkner, S. Hultgren, J. Kihlberg, 1997, FEBS letters.

Molecular dissection of PapD interaction with PapG reveals two chaperone‐binding sites

Z. Xu, J. Pinkner, S. Hultgren, 1995, Molecular microbiology.

Metabolite aberrations in early diabetes detected in rat kidney using mass spectrometry imaging

Ingela Lanekoff, J. Kihlberg, F. Palm, 2019, Analytical and Bioanalytical Chemistry.

Structure-activity relationships of galabioside derivatives as inhibitors of E. coli and S. suis adhesins: nanomolar inhibitors of S. suis adhesins.

J. Pinkner, S. Hultgren, J. Kihlberg, 2005, Organic & biomolecular chemistry.

Solution conformations explain the chameleonic behaviour of macrocyclic drugs.

Vasanthanathan Poongavanam, J. Kihlberg, M. Erdélyi, 2020, Chemistry.

An approach to enantiomerically pure inverse γ-turn mimetics for use in solid-phase synthesis

J. Kihlberg, P. Somfai, K. Brickmann, 1997 .

Design of Glycopeptides Used to Investigate Class II MHC Binding and T-Cell Responses Associated with Autoimmune Arthritis

Ida E. Andersson, C. D. Andersson, A. Linusson, 2011, PloS one.

Preparation of building blocks for glycopeptide synthesis by glycosylation of Fmoc amino acids having unprotected carboxyl groups

J. Kihlberg, M. Elofsson, L. A. Salvador, 1995 .

Deacetylation of Nα-methylated glycopeptides reveals that aza-enolates provide protection against β-elimination of carbohydrates O-linked to serine

J. Kihlberg, P. Sjölin, 2000 .

Quantitative structure-activity relationship of peptides binding to the class II major histocompatibility complex molecule Aq associated with autoimmune arthritis.

A. Linusson, R. Holmdahl, J. Kihlberg, 2007, Journal of medicinal chemistry.

Synthesis of a β-turn mimetic suitable for incorporation in the peptide hormone LHRH

J. Kihlberg, Zhongqing Yuan, 2005 .

Building blocks for glycopeptide synthesis: Preparation of α-O-fucosylated fmoc serine and threonine in one step from L-fucose tetraacetate

J. Kihlberg, M. Elofsson, L. A. Salvador, 1996 .

Glycosylation of type II collagen is of major importance for T cell tolerance and pathology in collagen‐induced arthritis

R. Holmdahl, J. Kihlberg, S. Issazadeh-Navikas, 2002, European journal of immunology.

Multivalent HSA Conjugates of 3′‐Sialyllactose are Potent Inhibitors of Adenoviral Cell Attachment and Infection

J. Kihlberg, G. Wadell, N. Arnberg, 2005, Chembiochem : a European journal of chemical biology.

Role of the Human ST6GalNAc-I and ST6GalNAc-II in the Synthesis of the Cancer-Associated Sialyl-Tn Antigen

J. Kihlberg, V. Morais, H. Clausen, 2004, Cancer Research.

Immunization with glycosylated Kb‐binding peptides generates carbohydrate‐specific, unrestricted cytotoxic T cells

J. Kihlberg, K. Karlsson, L. Berg, 1996, European journal of immunology.

Antigen processing and presentation of a naturally glycosylated protein elicits major histocompatibility complex class II‐restricted, carbohydrate‐specific T cells

R. Holmdahl, A. Engström, J. Kihlberg, 1996, European journal of immunology.

Influence of saccharide size on the cellular immune response to glycopeptides.

E. Unanue, J. Kihlberg, P. Sjölin, 2003, Organic & biomolecular chemistry.

MHC-restricted, glycopeptide-specific T cells show specificity for both carbohydrate and peptide residues.

E. Unanue, J. Kihlberg, P. Sjölin, 1999, Journal of immunology.

Specificity of glycopeptide-specific T cells.

E. Unanue, J. Kihlberg, M. Elofsson, 1995, Journal of immunology.

Chemoenzymatic Synthesis of Sialylated Glycopeptides Derived from Mucins and T-Cell Stimulating Peptides

J. Kihlberg, H. Clausen, C. Reis, 2002 .

Direct synthesis of glycosylated amino acids from carbohydrate peracetates and Fmoc amino acids: solid-phase synthesis of biomedicinally interesting glycopeptides.

J. Kihlberg, M. Elofsson, L. A. Salvador, 1997, Methods in enzymology.

Building blocks for glycopeptide synthesis: glycosylation of 3-mercaptopropionic acid and Fmoc amino acids with unprotected carboxyl groups

J. Kihlberg, M. Elofsson, B. Walse, 1991 .

Chemoenzymatic synthesis of derivatives of a T-cell-stimulating peptide which carry tumor-associated carbohydrate antigens

J. Kihlberg, H. Clausen, C. Reis, 2001 .

Synthesis of a C‐Glycoside Analogue of β‐D‐Galactosyl Hydroxynorvaline and Its Use in Immunological Studies

R. Holmdahl, J. Kihlberg, Eric Wellner, 2000 .

Synthesis of deoxy and alanine-substituted derivatives of a T cell stimulating glycopeptide—An investigation of conditions for cleavage from the solid phase and deprotection

J. Kihlberg, K. Bergquist, P. Sjölin, 1999 .

Solid-phase synthesis and conformational studies of helper T cell immunogenic peptides that carry carbohydrate haptens linked to serine.

J. Kihlberg, M. Elofsson, B. Walse, 2009, International journal of peptide and protein research.

Glycopeptides bind MHC molecules and elicit specific T cell responses.

E. Unanue, J. Kihlberg, C. Harding, 1993, Journal of immunology.

A surface exposed O-linked galactose residue destabilises the structure of a folded helix-loop-helix dimer.

J. Kihlberg, L. Andersson, L. Baltzer, 2003, Organic & biomolecular chemistry.

Is GPR146 really the receptor for proinsulin C-peptide?

J. Kihlberg, L. Sundström, Lina Lindfors, 2020, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of leucine enkephalin turn mimetics.

J. Kihlberg, C. Fowler, D. Blomberg, 2006, Organic & biomolecular chemistry.

Mining Natural Products for Macrocycles to Drug Difficult Targets

Vasanthanathan Poongavanam, J. Kihlberg, S. Geschwindner, 2020, Journal of medicinal chemistry.

Formation of lactones from sialylated MUC1 glycopeptides.

J. Kihlberg, C. Reis, M. Elofsson, 2006, Organic & biomolecular chemistry.

Gene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis

I. Mårtensson, R. Holmdahl, J. Kihlberg, 2016, PloS one.

Therapeutic Vaccination of Active Arthritis with a Glycosylated Collagen Type II Peptide in Complex with MHC Class II Molecules1

Kutty Selva Nandakumar, L. Fugger, R. Holmdahl, 2006, The Journal of Immunology.

in Complex with MHC Class II Molecules with a Glycosylated Collagen Type II Peptide Therapeutic Vaccination of Active Arthritis

Kutty Selva Nandakumar, L. Fugger, R. Holmdahl, 2006 .

Synthesis of an Array of Triple-Helical Peptides from Type II Collagen for Multiplex Analysis of Autoantibodies in Rheumatoid Arthritis.

C. Ge, Jie Yang, R. Holmdahl, 2020, ACS chemical biology.

A Shared Epitope of Collagen Type XI and Type II Is Recognized by Pathogenic Antibodies in Mice and Humans with Arthritis

Kutty Selva Nandakumar, Lei Li, C. Ge, 2018, Front. Immunol..

Removal of Acyl Protective Groups from Glycopeptides: Base Does Not Epimerize Peptide Stereocenters, and beta-Elimination Is Slow.

J. Kihlberg, M. Elofsson, P. Sjölin, 1996, The Journal of organic chemistry.

Role of the galactosyl moiety of collagen glycopeptides for T-cell stimulation in a model for rheumatoid arthritis.

R. Holmdahl, J. Kihlberg, L. Holm, 2003, Bioorganic & Medicinal Chemistry.

Preparation and calculated conformations of the 2′-, 3′-, 4′-, and 6′-deoxy, 3′-O-methyl, 4′-epi, and 4′- and 6′-deoxyfluoro derivatives of methyl 4-O-α-d-galactopyranosyl-β-d-galactopyranoside (methyl β-d-galabioside)

J. Kihlberg, G. Magnusson, T. Frejd, 1989 .

Synthetic receptor analogues: preparation and calculated conformations of the 2-deoxy, 6-O-methyl, 6-deoxy, and 6-deoxy-6-fluoro derivatives of methyl 4-O-α-d-galactopyranosyl-β-d-galactopyranoside (methyl β-d-galabioside)☆

J. Kihlberg, G. Magnusson, T. Frejd, 1988 .

Synthetic receptor analogues: the conformation of methyl 4-O-α-d-galactopyranosyl-β-d-galactopyranoside (methyl β-d-galabioside) and related derivatives, determined by N.M.R. and computational methods

J. Kihlberg, G. Magnusson, K. Bock, 1988 .

Synthetic receptor analogues: preparation of the 3-O-methyl, 3-C-methyl, and 3-deoxy derivatives of methyl 4-O-α-d-galactopyranosyl-β-d-galactopyranoside (methyl β-d-galabioside)

J. Kihlberg, T. Frejd, G. Magnusson, 1986 .

PROTAC cell permeability and oral bioavailability: a journey into uncharted territory.

Vasanthanathan Poongavanam, J. Kihlberg, 2021, Future medicinal chemistry.

Anti-adhesion and diagnostic strategies for oro-intestinal bacterial pathogens.

J. Kihlberg, M. Ryberg, K. Hammarström, 1996, Advances in experimental medicine and biology.

Reactive Oxygen Species Regulate Both Priming and Established Arthritis, but with Different Mechanisms.

R. Holmdahl, J. Kihlberg, O. Sareila, 2017, Antioxidants & redox signaling.

Steering New Drug Discovery Campaigns: Permeability, Solubility, and Physicochemical Properties in the bRo5 Chemical Space.

Vasanthanathan Poongavanam, J. Kihlberg, G. Caron, 2021, ACS medicinal chemistry letters.

Glycosylated peptide hormones: pharmacological properties and conformational studies of analogues of [1-desamino,8-D-arginine]vasopressin.

J. Kihlberg, T. Drakenberg, B. Walse, 1995, Journal of medicinal chemistry.

Drug Syntheses Beyond the Rule of 5.

Vasanthanathan Poongavanam, J. Kihlberg, M. Tyagi, 2020, Chemistry.

Convergent synthesis of neoglycopeptides by coupling of 2-bromoethyl glycosides to cysteine and homocysteine residues in T cell stimulating peptides

J. Kihlberg, J. Broddefalk, J. Dahmén, 1998, Glycoconjugate Journal.

Preparation of a glycopeptide analogue of type II collagen — Use of acid labile protective groups for carbohydrate moieties in solid phase synthesis of O-linked glycopeptides

J. Kihlberg, J. Broddefalk, K. Bergquist, 1996 .

Synthesis of a water-soluble serine-based neoglycolipid which can be covalently linked to solid phases.

J. Kihlberg, M. Elofsson, J. Broddefalk, 1994, Carbohydrate research.

An Improved Synthesis of 3,4,6-Tri-O-acetyl-2-azido-2-deoxy-α-d-galactopyranosyl Bromide: A Key Component for Synthesis of Glycopeptides and Glycolipids

J. Kihlberg, U. Nilsson, J. Broddefalk, 1994 .

Piperidine is preferable to morpholine for Fmoc cleavage in solid phase synthesis of O-linked glycopeptides

J. Kihlberg, Tatjana Vuljanic, 1993 .

Glycosylation of C-unprotected 3-mercaptopropionic acid and Fmoc amino acids: Application to the synthesis of glycosylated derivatives of a helper T-cell-stimulating peptide

J. Kihlberg, M. Elofsson, B. Walse, 1993 .

Synthesis of a novel β-turn mimetic and its incorporation in Leu-enkephalin

J. Kihlberg, Paul Kreye, 1999 .

Synthesis and biological evaluation of reversible inhibitors of IdeS, a bacterial cysteine protease and virulence determinant.

L. Björck, K. Luthman, B. Johansson, 2009, Bioorganic & medicinal chemistry.

Linker-Dependent Folding Rationalizes PROTAC Cell Permeability

Vasanthanathan Poongavanam, J. Kihlberg, M. Erdélyi, 2022, Journal of medicinal chemistry.

Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5.

Vasanthanathan Poongavanam, J. Kihlberg, G. Caron, 2018, Journal of medicinal chemistry.

Specificity mapping of bacterial lectins by inhibition of hemagglutination using deoxy and deoxyfluoro analogs of receptor-active saccharides.

S. Hultgren, J. Kihlberg, G. Magnusson, 1995, Methods in enzymology.

Preparation and structural characterization of N-glycated amino acid and linear or cyclic dipeptides containing the 6-amino-6-deoxy-1,2:3,4-di-O-isopropylidene-α--galactopyranose moiety

Š. Horvat, J. Kihlberg, M. Cudic, 1996 .

The PapG adhesin of uropathogenic Escherichia coli contains separate regions for receptor binding and for the incorporation into the pilus.

S. Hultgren, S. Normark, J. Kihlberg, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Cyclophilin Succumbs to a Macrocyclic Chameleon.

J. Kihlberg, B. Doak, 2018, Journal of medicinal chemistry.

A carbohydrate antigen linked to a T-cell immunogenic peptide induces T-cell clones selective for carbohydrate

E. Unanue, J. Kihlberg, C. Harding, 1993 .

Simulation Reveals the Chameleonic Behavior of Macrocycles

Vasanthanathan Poongavanam, R. Lindh, J. Kihlberg, 2022, J. Chem. Inf. Model..

An Improved Synthesis of a Galactosylated Hydroxylysine Building Block and its use in Solid-Phase Glycopeptide Synthesis

J. Kihlberg, Eric Wellner, J. Broddefalk, 2000 .

Piperidine is preferred to morpholine for Fmoc cleavage in solid phase glycopeptide synthesis as exemplified by preparation of glycopeptides related to HIV gp120 and mucins

J. Kihlberg, H. Clausen, K. Bergquist, 1996 .

Preparation of fluorinated linkers: use of 19F NMR spectroscopy to establish conditions for solid-phase synthesis of pilicide libraries.

J. Kihlberg, T. Fex, A. Svensson, 2000, Journal of combinatorial chemistry.

Design, synthesis and biological evaluation of thrombin inhibitors based on a pyridine scaffold.

J. Kihlberg, Yafeng Xue, T. Fex, 2007, Organic & biomolecular chemistry.

3 – Synthesis of Neoglycoconjugates

J. Kihlberg, G. Magnusson, L. Kononov, 1994 .

Macrocyclic Prodrugs of a Selective Nonpeptidic Direct Thrombin Inhibitor Display High Permeability, Efficient Bioconversion but Low Bioavailability.

J. Kihlberg, F. Bergström, G. Grönberg, 2016, Journal of medicinal chemistry.

How Big Is Too Big for Cell Permeability?

Jan Kihlberg, Pär Matsson, J. Kihlberg, 2017, Journal of medicinal chemistry.

3-Aminopiperidine-Based Peptide Analogues as the First Selective Noncovalent Inhibitors of the Bacterial Cysteine Protease IdeS

K. Luthman, J. Kihlberg, T. Fex, 2012, Journal of medicinal chemistry.

Unexpected formation of the 3,6-anhydro and 6-O-methyl-1-fluoro derivatives of galabiose on attempted substitution of HO-6 by fluorine in methyl 4-O-α-d-galactopyranosyl-β-d-galactopyranoside (methyl β-d-galabioside)

J. Kihlberg, G. Magnusson, T. Frejd, 1988 .

13C NMR Study of Dihydropyrimidinedione and Dihydropyrimidine‐2‐thione Derivatives

J. Kihlberg, J. Broddefalk, Z. Beresnevičius, 1997 .

Synthesis of Substrates for Aldolase-Catalysed Reactions: A Comparison of Methods for the Synthesis of Substituted Phenylacetaldehydes

J. Kihlberg, M. Widersten, T. Norberg, 2018 .

Use of 19F NMR spectroscopy to evaluate reactions in solid phase organic synthesis

J. Kihlberg, T. Fex, A. Svensson, 1996 .

Probing molecular interactions within class II MHC Aq/glycopeptide/T-cell receptor complexes associated with collagen-induced arthritis.

A. Linusson, R. Holmdahl, J. Kihlberg, 2007, Journal of medicinal chemistry.

The sesquiterpenes of Lactarius vellereus and their role in a proposed chemical defense system.

J. Kihlberg, O. Sterner, B. Wickberg, 1985 .

The in situ activation of thioglycosides with bromine: an improved glycosylation method

J. Kihlberg, D. Leigh, D. Bundle, 1990 .

Solid-phase synthesis of alpha-Gal epitopes: on-resin analysis of solid-phase oligosaccharide synthesis with 19F NMR spectroscopy.

J. Kihlberg, M. Elofsson, M. Mogemark, 2003, The Journal of organic chemistry.

Use of acid-labile protective groups for carbohydrate moieties in synthesis of glycopeptides related to type II collagen

J. Kihlberg, J. Broddefalk, K. Bergquist, 1998 .

Glycopeptide Specificity of Helper T Cells Obtained in Mouse Models for Rheumatoid Arthritis

R. Holmdahl, J. Kihlberg, J. Bäcklund, 2002, Chembiochem : a European journal of chemical biology.

Preparation of Tn and sialyl Tn building blocks used in Fmoc solid-phase synthesis of glycopeptide fragments from HIV gp120

J. Kihlberg, M. Elofsson, L. A. Salvador, 1997 .

Diastereoselective synthesis of methyl α-kedarosaminide, a carbohydrate moiety of the enediyne antitumor antibiotic kedarcidin chromophore

J. Kihlberg, P. Somfai, Tatjana Vuljanic, 1994 .

A synthetic approach to 2,3,4-substituted pyridines useful as scaffolds for tripeptidomimetics

K. Luthman, J. Kihlberg, Stina Saitton, 2004 .

The design and synthesis of antibody binding site probes: three pentasaccharide analogues of the Brucella A antigen prepared by activation in situ of thioglycosides with bromine.

J. Kihlberg, E. Eichler, D. Bundle, 1991, Carbohydrate research.

Chemical and Biochemical Approaches for the Synthesis of Substituted Dihydroxybutanones and Di- and Tri-Hydroxypentanones.

J. Kihlberg, V. Kessler, M. Widersten, 2019, The Journal of organic chemistry.

2-(Trimethylsilyl)ethyl glycosides. 3. Synthesis, anomeric deblocking, and transformation into 1,2-trans 1-O-acyl sugars

J. Kihlberg, J. Dahmén, G. Noori, 1988 .

Boron trifluoride etherate as an effective reagent for the stereoselective one-pot conversion of acetylated 2-trimethylsilylethyl glycosides into sugar 1,2-trans-acetates

J. Kihlberg, T. Frejd, G. Magnusson, 1986 .

Use of fluorobenzoyl protective groups in synthesis of glycopeptides: beta-elimination of O-linked carbohydrates is suppressed.

J. Kihlberg, P. Sjölin, 2001, The Journal of organic chemistry.

Synthesis of a C-glycoside analogue of beta-D-galactosyl hydroxylysine and incorporation in a glycopeptide from type II collagen.

J. Kihlberg, M. Hedenström, T. Gustafsson, 2006, The Journal of organic chemistry.

Synthesis of Tn and sialyl Tn building blocks for solid phase glycopeptide synthesis

J. Kihlberg, M. Elofsson, 1995 .

Solid‐Phase Synthesis of Glycopeptides: Immunological Studies with T Cell Stimulating Glycopeptides

J. Kihlberg, M. Elofsson, 1997 .

Toward the Design of Molecular Chameleons: Flexible Shielding of an Amide Bond Enhances Macrocycle Cell Permeability.

Vasanthanathan Poongavanam, J. Kihlberg, M. Tyagi, 2018, Organic letters.

Synthesis of Conformationally Restricted Mimetics of γ‐Turns and Incorporation into Desmopressin, an Analogue of the Peptide Hormone Vasopressin

J. Kihlberg, I. Sethson, P. Somfai, 1999 .

Conformation of desmopressin, an analogue of the peptide hormone vasopressin, in aqueous solution as determined by NMR spectroscopy.

J. Kihlberg, T. Drakenberg, B. Walse, 1998, European journal of biochemistry.

Drug discovery beyond the rule of 5 - Opportunities and challenges

Bradley C Doak, Jan Kihlberg, J. Kihlberg, 2017, Expert opinion on drug discovery.

Stereoselective Synthesis of Ψ[CH2O] Pseudodipeptides and Conformational Analysis of a PheΨ[CH2O]Ala Containing Analogue of the Drug Desmopressin

J. Kihlberg, M. Hedenström, H. Emtenäs, 2002 .

Synthesis and conformational studies of a beta-turn mimetic incorporated in Leu-enkephalin.

J. Kihlberg, M. Hedenström, I. Sethson, 2004, The Journal of organic chemistry.

Synthesis of a C-Glycoside Analogue of β-d-Galactosylthreonine

J. Kihlberg, T. Gustafsson, Maria Saxin, 2003 .

Major histocompatibility complex class I binding glycopeptides for the estimation of 'empty' class I molecules.

J. Kihlberg, L. Berg, G. Magnusson, 1995, Journal of immunological methods.

Basidiomycete sesquiterpenes: the silica gel induced degradation of velutinal derivatives

J. Kihlberg, O. Sterner, P. V. Finzi, 1985 .

Use of 19F NMR spectroscopy to screen chemical libraries for ligands that bind to proteins.

Tomas Fex, Fredrik Almqvist, Jan Kihlberg, 2004, Organic & biomolecular chemistry.

Binding of peptides in solution by the Escherichia coli chaperone PapD as revealed using an inhibition ELISA and NMR spectroscopy.

J. Pinkner, S. Hultgren, J. Kihlberg, 1998, Bioorganic & medicinal chemistry.

Access to fluorescent probes via allyl glycosides: the synthesis of aBrucella trisaccharide epitope linked to a coumarin

J. Kihlberg, E. Eichler, D. Bundle, 1991, Glycoconjugate Journal.

The synthesis of antibody binding-site probes: a hexasaccharide and two pentasaccharides related to the Brucella A antigen and prepared by in situ activation of thioglycosides with bromine.

J. Kihlberg, D. Bundle, 1992, Carbohydrate research.

Application of gel‐phase 19F NMR spectroscopy for optimization of solid‐phase synthesis of a hydrophobic peptide from the signal sequence of the mucin MUC1

J. Kihlberg, M. Elofsson, Maciej Pudelko, 2007, Journal of peptide science : an official publication of the European Peptide Society.

Quantitative studies of the binding of the class II PapG adhesin from uropathogenic Escherichia coli to oligosaccharides.

Jörgen Ohlsson, Ulf Nilsson, Jan Kihlberg, 2003, Bioorganic & medicinal chemistry.

Preparation of partially 2H/13C-labelled RNA for NMR studies. Stereo-specific deuteration of the H5" in nucleotides.

S. Wijmenga, J. Kihlberg, J. Schleucher, 2002, Nucleic acids research.

Use of carbohydrates and peptides in studies of adhesion of pathogenic bacteria and in efforts to generate carbohydrate-specific T cells

J. Kihlberg, G. Magnusson, 1996 .

Probing of the combining site of the PapG adhesin of uropathogenic Escherichia coli bacteria by synthetic analogs of galabiose

S. Hultgren, S. Normark, J. Kihlberg, 1989 .

Synthesis of the Cancer-Associated Sialyl-Tn Antigen Role of the Human ST 6 GalNAc-I and ST 6 GalNAc-II in the Updated

J. Kihlberg, V. Morais, H. Clausen, 2004 .

Development and characterization of an antibody directed to an α-N-acetyl-D-galactosamine glycosylated MUC2 peptide

P. Roepstorff, J. Kihlberg, E. Mirgorodskaya, 2004, Glycoconjugate Journal.

A fluorinated selenide linker for solid-phase synthesis of n-pentenyl glycosides.

J. Kihlberg, M. Elofsson, Christoffer Bengtsson, 2004, Organic letters.

Gel-phase 19F NMR spectral quality for resins commonly used in solid-phase organic synthesis; a study of peptide solid-phase glycosylations.

J. Kihlberg, M. Elofsson, M. Mogemark, 2004, Organic & biomolecular chemistry.

Fluorinated Protective Groups for On‐Resin Quantification of Solid‐Phase Oligosaccharide Synthesis with 19F NMR Spectroscopy

J. Kihlberg, M. Elofsson, M. Mogemark, 2002, Chembiochem : a European journal of chemical biology.

Monitoring solid-phase glycoside synthesis with (19)F NMR spectroscopy.

J. Kihlberg, M. Elofsson, M. Mogemark, 2001, Organic letters.

A total synthesis of hydroxylysine in protected form and investigations of the reductive opening of p-methoxybenzylidene acetals.

J. Kihlberg, M. Schou, F. Almqvist, 2004, The Journal of organic chemistry.

(E)-alkene and ethylene isosteres substantially alter the hydrogen-bonding network in class II MHC A(q)/glycopeptide complexes and affect T-cell recognition.

Ida E. Andersson, A. Linusson, R. Holmdahl, 2011, Journal of the American Chemical Society.

Preparation of a Diglycosylated Hydroxylysine Building Block Used in Solid-Phase Synthesis of a Glycopeptide from Type II Collagen.

J. Kihlberg, I. Sethson, J. Broddefalk, 1999, The Journal of organic chemistry.

T Cells Recognize a Glycopeptide Derived from Type II Collagen in a Model for Rheumatoid Arthritis

R. Holmdahl, J. Kihlberg, F. Almqvist, 1998 .

Side-chain and backbone amide bond requirements for glycopeptide stimulation of T-cells obtained in a mouse model for rheumatoid arthritis.

R. Holmdahl, J. Kihlberg, L. Holm, 2006, Bioorganic & medicinal chemistry.

Conformations and Receptor Activity of Desmopressin Analogues, Which Contain γ-Turn Mimetics or a Ψ[CH2O] Isostere

J. Kihlberg, M. Hedenström, I. Sethson, 2002 .

The structure of a novel sesquiterpene furna alcohol with a lactarane skeleton

J. Kihlberg, O. Sterner, L. Nilsson, 1983 .

T cells specific for post-translational modifications escape intrathymic tolerance induction

B. Kyewski, R. Holmdahl, J. Kihlberg, 2018, Nature Communications.

Identification of the minimal glycopeptide core recognized by T cells in a model for rheumatoid arthritis.

R. Holmdahl, J. Kihlberg, L. Holm, 2005, Bioorganic & medicinal chemistry.

The structural basis of MHC control of collagen‐induced arthritis; binding of the immunodominant type II collagen 256 – 270 glycopeptide to H‐2Aq and H‐2Ap molecules

L. Fugger, R. Holmdahl, A. Engström, 1998, European journal of immunology.

Enhancing preclinical drug discovery with artificial intelligence.

Vasanthanathan Poongavanam, J. Kihlberg, J. Cross, 2021, Drug discovery today.

Epitope glycosylation plays a critical role for T cell recognition of type II collagen in collagen‐induced arthritis

R. Holmdahl, J. Kihlberg, E. Michaëlsson, 1998, European journal of immunology.

Solid-phase synthesis and conformational studies of glycosylated derivatives of helper-T-cell immunogenic peptides from hen-egg lysozyme.

J. Kihlberg, M. Elofsson, B. Walse, 1993, Carbohydrate research.

Hypothesis driven drug design: improving quality and effectiveness of the design-make-test-analyse cycle.

R. A. Thompson, Jonas Pettersson, Jan Kihlberg, 2012, Drug discovery today.

Multifunctional T cell reactivity with native and glycosylated type II collagen in rheumatoid arthritis.

Ida E. Andersson, L. Klareskog, R. Holmdahl, 2012, Arthritis and rheumatism.

Autoantibodies to Disease‐Related Proteins in Joints as Novel Biomarkers for the Diagnosis of Rheumatoid Arthritis

L. Jacobsson, R. Holmdahl, J. Kihlberg, 2023, Arthritis & rheumatology.

Intramolecular hydrogen bonding: An opportunity for improved design in medicinal chemistry

Giulia Caron, Giuseppe Ermondi, Jan Kihlberg, 2019, Medicinal research reviews.

Cutting Edge: Processing of Oxidized Peptides in Macrophages Regulates T Cell Activation and Development of Autoimmune Arthritis

C. Ge, R. Holmdahl, J. Kihlberg, 2017, The Journal of Immunology.

Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritis

I. Mårtensson, R. Holmdahl, J. Kihlberg, 2016, Arthritis Research & Therapy.

Predominant selection of T cells specific for the glycosylated collagen type II epitope (263–270) in humanized transgenic mice and in rheumatoid arthritis

L. Fugger, R. Holmdahl, J. Kihlberg, 2002, Proceedings of the National Academy of Sciences of the United States of America.

T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritis

R. Holmdahl, J. Kihlberg, V. Malmström, 2000, Arthritis research.

Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes.

Ida E. Andersson, C. Lindgren, A. Linusson, 2015, Organic & biomolecular chemistry.

Oxazole-modified glycopeptides that target arthritis-associated class II MHC A(q) and DR4 proteins.

Ida E. Andersson, A. Linusson, R. Holmdahl, 2010, Organic & biomolecular chemistry.

Structure‐Guided Design of G‐Protein‐Coupled Receptor Polypharmacology

P. Svenningsson, P. Matricon, M. Loza, 2021, Angewandte Chemie.

2-trimethylsilylethyl glycosides. Anomeric deblocking of mono- and disaccharides.

J. Kihlberg, T. Frejd, G. Magnusson, 1988 .

Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.

P. Nilsson, C. Ge, R. Holmdahl, 2017, JCI insight.

Chemoenzymatic synthesis of sialylated glycopeptides derived from mucins and T-cell stimulating peptides.

J. Kihlberg, H. Clausen, C. Reis, 2001, Journal of the American Chemical Society.

The major T cell epitope on type II collagen is glycosylated in normal cartilage but modified by arthritis in both rats and humans

O. Johnell, R. Holmdahl, J. Kihlberg, 2005, European journal of immunology.

Structural and conformational determinants of macrocycle cell permeability.

Ulf Norinder, Christian Tyrchan, Giovanni Muncipinto, 2016, Nature chemical biology.

Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses

J. Lennerstrand, J. Kihlberg, Å. Lundkvist, 2022, Journal of the American Chemical Society.

Multivariate design, synthesis, and biological evaluation of peptide inhibitors of FimC/FimH protein-protein interactions in uropathogenic Escherichia coli.

Anna Linusson, Fredrik Almqvist, Jan Kihlberg, 2005, Journal of Medicinal Chemistry.

Macrocyclic Peptides Uncover a Novel Binding Mode for Reversible Inhibitors of LSD1

Vasanthanathan Poongavanam, Jie Yang, B. Simon, 2020, ACS omega.

Conformational Sampling of Macrocyclic Drugs in Different Environments: Can We Find the Relevant Conformations?

Stanislaw Wlodek, Paul C. D. Hawkins, Giulia Caron, 2018, ACS omega.

Macrocycles in Drug Discovery—Learning from the Past for the Future

Vasanthanathan Poongavanam, J. Kihlberg, Diego García Jiménez, 2023, Journal of medicinal chemistry.

Synthesis and cis–trans isomerism in novel Leu-enkephalin-related peptidomimetics containing N-glycated glycine residues

Š. Horvat, J. Kihlberg, M. Cudic, 1998 .

Hierarchical PLS Modeling for Predicting the Binding of a Comprehensive Set of Structurally Diverse Protein-Ligand Complexes

Anders Berglund, Fredrik Pettersson, Anton Lindström, 2006, J. Chem. Inf. Model..

T cells specific for post-translational modifications escape intrathymic tolerance induction

B. Kyewski, R. Holmdahl, J. Kihlberg, 2018, Nature Communications.

Making medicinal chemistry more effective--application of Lean Sigma to improve processes, speed and quality.

Nidhal Selmi, Jan Kihlberg, Magnus J. Johansson, 2009, Drug discovery today.

Solution Conformations Shed Light on PROTAC Cell Permeability

Vasanthanathan Poongavanam, J. Kihlberg, M. Erdélyi, 2020, ACS medicinal chemistry letters.

Employing complementary spectroscopies to study the conformations of an epimeric pair of side-chain stapled peptides in aqueous solution

J. Kihlberg, C. Johannessen, M. Erdélyi, 2021, RSC advances.

Design and Evaluation of Pilicides: Potential Novel Antibacterial Agents Directed Against Uropathogenic Escherichia coli

J. Pinkner, S. Hultgren, J. Kihlberg, 2001, Chembiochem : a European journal of chemical biology.

Structure-based virtual screening discovers potent and selective adenosine A1 receptor antagonists.

P. Matricon, A. T. Nguyen, Joanne Baltos, 2023, European journal of medicinal chemistry.

Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1–Nrf2 Protein–Protein Interaction

P. Matricon, R. Lewis, J. Kihlberg, 2022, Journal of medicinal chemistry.

Mild Oxidative Cleavage of 9‐BBN‐Protected Amino Acid Derivatives

J. Kihlberg, T. Norberg, T. Ankner, 2015 .

Mild Oxidative Cleavage of 9‐BBN‐Protected Amino Acid Derivatives.

J. Kihlberg, T. Norberg, T. Ankner, 2015 .

9-BBN as a convenient protecting group in functionalisation of hydroxylysine

J. Kihlberg, T. Gustafsson, Baquer M Syed, 2004 .

Opportunities and guidelines for discovery of orally absorbed drugs in beyond rule of 5 space.

Bradley C Doak, Jan Kihlberg, Vasanthanathan Poongavanam, 2018, Current opinion in chemical biology.

Synthesis and conformational studies of peptides fromE. coli pilus proteins recognized by the chaperone PapD

J. Kihlberg, T. Drakenberg, B. Walse, 1996, Letters in Peptide Science.

Synthesis of β-Benzyl N-(tert-Butoxycarbonyl)-L-erythro-β-(benzyloxy)aspartate from (R,R)-(+)-Tartaric Acid.

J. Kihlberg, T. Hansson, 1987 .

Synthesis of .beta.-benzyl N-(tert-butoxycarbonyl)-L-erythro-.beta.-(benzyloxy)aspartate from (R,R)-(+)-tartaric acid

J. Kihlberg, T. Hansson, 1986 .

Synthesis and evaluation of novel pyridine based PLG tripeptidomimetics.

K. Luthman, J. Kihlberg, Andria L. Del Tredici, 2008, Organic & biomolecular chemistry.

Design, synthesis and evaluation of a PLG tripeptidomimetic based on a pyridine scaffold.

K. Luthman, J. Kihlberg, D. Boström, 2004, Journal of medicinal chemistry.

Frontline : The major T cell epitope on type II collagen is glycosylated in normal cartilage butmodified by arthritis in both rats and humans

O. Johnell, R. Holmdahl, J. Kihlberg, 2005 .

Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor

C. Ge, R. Holmdahl, H. Lanig, 2022, Annals of the Rheumatic Diseases.

Docking finds GPCR ligands in dark chemical matter.

J. Irwin, M. Loza, J. Brea, 2019, Journal of medicinal chemistry.

Synthesis of a β-strand mimetic based on a pyridine scaffold

J. Kihlberg, D. Blomberg, K. Brickmann, 2006 .

Cell Permeability of Isomeric Macrocycles: Predictions and NMR Studies

Vasanthanathan Poongavanam, J. Kihlberg, Stefan Schiesser, 2021, ACS medicinal chemistry letters.

Correction to Synthesis of an Array of Triple-Helical Peptides from Type II Collagen for Multiplex Analysis of Autoantibodies in Rheumatoid Arthritis.

C. Ge, Jie Yang, R. Holmdahl, 2020, ACS Chemical Biology.

Synthesis of an N-linked glycopeptide from vitamin K-dependent protein S

S. Linse, J. Kihlberg, B. Holm, 1998 .

Conformational Sampling Deciphers the Chameleonic Properties of a VHL-Based Degrader

J. Kihlberg, G. Caron, G. Ermondi, 2023, Pharmaceutics.

Going Viral: An Investigation into the Chameleonic Behaviour of Antiviral Compounds

Vasanthanathan Poongavanam, J. Kihlberg, M. Erdélyi, 2022, Chemistry.

Solubility prediction in the bRo5 chemical space: where are we right now?

Vasanthanathan Poongavanam, J. Kihlberg, G. Caron, 2020, ADMET & DMPK.

Predictive Modeling of PROTAC Cell Permeability with Machine Learning

Vasanthanathan Poongavanam, J. Kihlberg, A. Göller, 2023, ACS omega.

Predicting the Permeability of Macrocycles from Conformational Sampling - Limitations of Molecular Flexibility.

Giulia Caron, Giuseppe Ermondi, Vasanthanathan Poongavanam, 2020, Journal of pharmaceutical sciences.

T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritis

R. Holmdahl, J. Kihlberg, V. Malmström, 2000, Arthritis research.

NMR studies of interactions between periplasmic chaperones from uropathogenic E. coli and pilicides that interfere with chaperone function and pilus assembly.

J. Pinkner, S. Hultgren, J. Kihlberg, 2005, Organic & biomolecular chemistry.

Design and Evaluation of Pilicides: Potential Novel Antibacterial Agents Directed Against Uropathogenic Escherichia coli.

J. Pinkner, S. Hultgren, J. Kihlberg, 2002 .

Periplasmic chaperone recognition motif of subunits mediates quaternary interactions in the pilus

S. Hultgren, S. Knight, K. Dodson, 1998, The EMBO journal.

(E)-alkene and ethylene isosteres substantially alter the hydrogen-bonding network in class II MHC A(q)/glycopeptide complexes and affect T-cell recognition.

Ida E. Andersson, A. Linusson, R. Holmdahl, 2011, Journal of the American Chemical Society.

Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice

J. Kihlberg, C. Sjöwall, A. Kastbom, 2023, The Journal of experimental medicine.

Molecular chameleons in drug discovery

Vasanthanathan Poongavanam, J. Kihlberg, M. Erdélyi, 2023, Nature reviews. Chemistry.

The effect of glycosylation on the structure of designed four-helix bundle motifs

J. Kihlberg, L. Andersson, L. Baltzer, 2000 .