P. Nielsen

发表

Synthesis and modelling of DNA junction and minor groove zipper motifs incorporating the double-headed nucleoside 5'(S)-C-(thymine-1-ylmethyl)thymidine.

Mikkel S. Christensen, C. Madsen, P. Nielsen, 2007, Organic & biomolecular chemistry.

LNA (Locked Nucleic Acid): An RNA Mimic Forming Exceedingly Stable LNA:LNA Duplexes

J. Wengel, P. Nielsen, A. Koshkin, 1998 .

Synthesis, hybridization and fluorescence properties of a 2'-C-pyrene-triazole modified arabino-uridine nucleotide.

P. Nielsen, P. Sharma, Pawan Kumar, 2017, Bioorganic & medicinal chemistry.

Synthesis of new C-5-triazolyl-functionalized thymidine analogs and their ability to engage in aromatic stacking in DNA : DNA and DNA : RNA duplexes.

P. Nielsen, M. Hornum, Alevtina Djukina, 2016, Organic & biomolecular chemistry.

Dinucleotides containing two allyl groups by combinations of allyl phosphotriesters, 5-allyl-, 2′-O-allyl- and 2′-arabino-O-allyl uridine derivatives as substrates for ring-closing metathesis

P. Nielsen, Philip Børsting, M. Freitag, 2004 .

α‐LNA (Locked Nucleic Acid with α‐D‐Configuration): Synthesis and Selective Parallel Recognition of RNA

P. Nielsen, N. Christensen, J. Dalskov, 2002 .

A conformationally locked tricyclic nucleoside. Synthesis, crystal structure and incorporation into oligonucleotides

P. Nielsen, Jacob Ravn, N. Thorup, 2001 .

Synthesis and NMR-studies of dinucleotides with conformationally restricted cyclic phosphotriester linkages

P. Nielsen, J. Jacobsen, A. M. Sørensen, 2001 .

Synthesis of conformationally restricted dinucleotides by ring-closing metathesis.

P. Nielsen, A. M. Sørensen, 2000, Organic letters.

α-LNA, locked nucleic acid with α-D-configuration

P. Nielsen, J. Dalskov, 2000 .

The eight stereoisomers of LNA (Locked Nucleic Acid): A remarkable family of strong RNA binding molecules

S. Pitsch, J. Wengel, P. Nielsen, 2000 .

A novel class of conformationally restricted oligonucleotide analogues: synthesis of 2',3'-bridged monomers and RNA-selective hybridisation

J. Wengel, P. Nielsen, H. Pfundheller, 1997 .

LNA (LOCKED NUCLEIC ACID)

C. Olsen, J. Skouv, J. Wengel, 1999 .

A ring-closing metathesis based synthesis of bicyclic nucleosides locked in S-type conformations by hydroxyl functionalised 3′,4′-trans linkages

P. Nielsen, M. Freitag, N. Christensen, 2004 .

3',4'-trans-linked bicyclic nucleosides locked in S-type conformations.

J. Wengel, P. Nielsen, M. Meldgaard, 2002, Chemical communications.

SYNTHESIS AND NMR-ANALYSIS OF TRICYCLIC NUCLEOSIDES

P. Nielsen, J. Jacobsen, M. Petersen, 2001, Nucleosides, nucleotides & nucleic acids.

Synthesis of bicyclic nucleosides by ring-closing metathesis

P. Nielsen, Jacob Ravn, 2001 .

Tricyclic nucleosides derived from D-glucose: Synthesis and conformational behaviour

P. Nielsen, J. Jacobsen, M. Petersen, 2000 .

Synthesis and antiviral evaluation of novel conformationally locked nucleosides and masked 5′-phosphate derivatives thereof

J. Wengel, P. Nielsen, T. Koch, 2002 .

LNA (locked nucleic acid) and analogs as triplex-forming oligonucleotides.

J. Wengel, P. Nielsen, P. Sharma, 2007, Organic & biomolecular chemistry.

Increasing the Stability of DNA:RNA Duplexes by Introducing Stacking Phenyl-Substituted Pyrazole, Furan, and Triazole Moieties in the Major Groove.

P. Nielsen, Pawan Kumar, M. Hornum, 2015, The Journal of organic chemistry.

Palladium-catalyzed three-component approach to promazine with formation of one carbon-sulfur and two carbon-nitrogen bonds.

P. Nielsen, C. W. Tornøe, B. Bang-Andersen, 2008, Angewandte Chemie.

Synthesis and evaluation of oligodeoxynucleotides containing acyclic nucleosides: introduction of three novel analogues and a summary.

J. Wengel, P. Nielsen, L. H. Dreiøe, 1995, Bioorganic & medicinal chemistry.

Synthesis and Antiviral Evaluation of Novel Conformationally Locked Nucleosides and Masked 5′-Phosphate Derivatives Thereof.

J. Wengel, P. Nielsen, T. Koch, 2002 .

Chemically modified oligonucleotides with efficient RNase H response.

Raunak, J. Wengel, P. Nielsen, 2008, Bioorganic & medicinal chemistry letters.

A Novel Class of Oligonucleotide Analogues Containing 2'-O,3'-C-Linked [3.2.0]Bicyclo-arabinonucleoside Monomers: Synthesis, Thermal Affinity Studies and Molecular Modelling

C. Olsen, J. Wengel, P. Nielsen, 1998 .

Stereoselective Preparation of 3'-C-Allyluridines and 3'-Spiro-gamma-Lactone Uridine Analogues

J. Wengel, P. Nielsen, K. Larsen, 1996 .

Three new double-headed nucleotides with additional nucleobases connected to C-5 of pyrimidines; synthesis, duplex and triplex studies.

P. Nielsen, P. Sharma, Pawan Kumar, 2016, Bioorganic & medicinal chemistry.

Nucleic acid secondary structures containing the double-headed nucleoside 5'(S)-C-(2-(thymin-1-yl)ethyl)thymidine.

Mikkel S. Christensen, C. Madsen, P. Nielsen, 2008, Organic & biomolecular chemistry.

A double-headed nucleotide with two cytosines: DNA with condensed information and improved duplex stability.

P. Nielsen, Christian Henriksen, M. Hornum, 2019, Bioorganic & medicinal chemistry letters.

Double-headed nucleotides with arabino configuration: synthesis and hybridization properties.

P. Nielsen, P. Sharma, Pawan Kumar, 2014, The Journal of organic chemistry.

High-affinity RNA targeting by oligonucleotides displaying aromatic stacking and amino groups in the major groove. Comparison of triazoles and phenyl substituents.

C. Len, P. Nielsen, Pawan Kumar, 2014, The Journal of organic chemistry.

High-affinity DNA targeting using readily accessible mimics of N2'-functionalized 2'-amino-α-L-LNA.

P. Nielsen, P. Hrdlicka, Saswata Karmakar, 2011, The Journal of organic chemistry.

Structural basis of cleavage by RNase H of hybrids of arabinonucleic acids and RNA.

M. Teplova, M. Egli, G. Minasov, 2000, Biochemistry.

LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

Poul Nielsen, Carl Erik Olsen, C. Olsen, 1998 .

Synthesis of a bicyclic double-headed nucleoside

P. Nielsen, Nanna Albæk, Santosh Kumar, 2014 .

Synthesis of the 3′-C-Hydroxymethyl-Branched Locked Nucleic Acid Thymidine Monomer

P. Nielsen, P. Stein, P. Sharma, 2008 .

Parallel nucleic acid recognition by the LNA (locked nucleic acid) stereoisomers β-L-LNA and α-D-LNA; studies in the mirror image world

J. Wengel, P. Nielsen, K. Arar, 2004 .

Synthesis of hydroxymethyl branched [3.2.0]bicyclic nucleosides using a regioselective oxetane ring-formation.

P. Nielsen, N. Christensen, A. Andersen, 2003, Organic & biomolecular chemistry.

α-LNA (α-D-Configured Locked Nucleic Acid)

P. Nielsen, B. Vester, N. Christensen, 2003 .

Bi- and Tricyclic Nucleoside Derivatives Restricted in S-Type Conformations and Obtained by RCM-Reactions

P. Nielsen, M. Freitag, N. Christensen, 2003, Nucleosides, nucleotides & nucleic acids.

Bicyclic nucleosides; stereoselective dihydroxylation and 2'-deoxygenation.

P. Nielsen, M. Freitag, Jacob Ravn, 2003, Organic & biomolecular chemistry.

A new synthetic approach towards ?- and ?-LNA (locked nucleic acids)

P. Nielsen, J. Wengel, P. Nielsen, 1999 .

Synthesis and chemoselective activation of phenyl 3,5-di-O-benzyl-2-O,4-C-methylene-1-thio-β-D-ribofuranoside: a key synthon towards α-LNA

J. Wengel, P. Nielsen, 1998 .

Collision-induced dissociation of cytidine and its derivatives.

P. Nielsen, F. Kirpekar, S. S. Jensen, 2007, Journal of mass spectrometry : JMS.

Double‐Headed Nucleotides with Non‐Native Nucleobases: Synthesis and Duplex Studies

P. Nielsen, M. Hornum, Kasper M. Beck, 2021 .

An alpha-D-configured bicyclic nucleoside restricted in an E-type conformation: synthesis and parallel RNA recognition.

P. Nielsen, P. Sharma, M. Petersen, 2005, The Journal of organic chemistry.

Discovery of a Potent Adenine-Benzyltriazolo-Pleuromutilin Conjugate with Pronounced Antibacterial Activity against MRSA.

J. Kongsted, P. Nielsen, C. Nielsen, 2020, Journal of medicinal chemistry.

Tandem ring-closing metathesis and hydrogenation towards cyclic dinucleotides.

P. Nielsen, Philip Børsting, 2002, Chemical communications.

Synthesis of bicyclic 2'-deoxynucleosides with alpha-L-ribo- and beta-D-xylo-configurations and restricted S- and N-type conformations.

P. Nielsen, A. Bond, P. Sharma, 2009, The Journal of organic chemistry.

SYNTHESIS OF 2'-O,3'-C-LINKED BICYCLIC NUCLEOSIDES AND BICYCLIC OLIGONUCLEOTIDES

C. Olsen, J. Wengel, P. Nielsen, 1997 .

Selective reduction of mono- and disubstituted olefins by NaBH4 and catalytic RuCl3

P. Nielsen, P. Sharma, Surender Kumar, 2007 .

Synthesis of 6'-branched locked nucleic acid by a radical TEMPO-scavanged stereoselective mercury cyclization.

P. Nielsen, G. Enderlin, 2008, The Journal of organic chemistry.

Double-headed nucleotides in DNA-zipper structures; base–base interactions and UV-induced cross-coupling in the minor groove

P. Nielsen, L. J. Nielsen, A. Lauritsen, 2013 .

Synthesis and molecular modelling of double-functionalised nucleosides with aromatic moieties in the 5'-(S)-position and minor groove interactions in DNA zipper structures.

P. Nielsen, L. J. Nielsen, A. Jørgensen, 2010, Chemistry.

A cyclic dinucleotide with a four-carbon 5'-C-to-5'-C connection; synthesis by RCM, NMR-examination and incorporation into secondary nucleic acid structures.

Mikkel S. Christensen, P. Nielsen, P. Sharma, 2006, Organic & biomolecular chemistry.

LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition

Poul Nielsen, J. Wengel, P. Nielsen, 1998 .

Analysis of Tetracycline, Oxytetracycline and Chlortetracycline in Plasma Extracts by Electrospray Tandem Mass-Spectrometry and by Liquid Chromatography

P. Nielsen, G. Bojesen, A. Weimann, 1998 .

An efficient protocol for the stereoselective dihydroxylation of ene-ester systems

P. Nielsen, S. Roberts, S. Hermitage, 1998 .

Synthesis of dinucleotides with 2′-C to phosphate connections by ring-closing metathesis

Mikkel S. Christensen, P. Nielsen, Philip Børsting, 2006 .

Two Carbocyclic Locked Nucleic Acid Analogues Give Structural Information about the Role of Hydration in A-Type Duplexes

P. Nielsen, M. Petersen, Nanna Albæk, 2007, Nucleosides, nucleotides & nucleic acids.

SYNTHESIS OF CONFORMATIONALLY RESTRICTED NUCLEIC ACID FRAGMENTS USING RING-CLOSING ALKENE AND ENYNE METATHESIS REACTIONS

Mikkel S. Christensen, P. Nielsen, S. I. Steffansen, 2005, Nucleosides, nucleotides & nucleic acids.

Design, synthesis and ribosome binding of chloramphenicol nucleotide and intercalator conjugates.

P. Nielsen, B. Vester, Jacob Pøhlsgaard, 2005, Bioorganic & medicinal chemistry letters.

Synthetic nucleic acid secondary structures containing the four stereoisomers of 1,4-bis(thymine-1-yl)butane-2,3-diol.

Mikkel S. Christensen, P. Nielsen, A. Bond, 2008, Organic & biomolecular chemistry.

Base-Pairing Properties of Double-Headed Nucleotides.

P. Nielsen, P. Sharma, Pawan Kumar, 2019, Chemistry.

A Novel Class of Oligonucleotide Analogues Containing 2′‐O,3′‐C‐Linked [3.2.0]Bicycloarabinonucleoside Monomers: Synthesis, Thermal Affinity Studies, and Molecular Modeling.

C. Olsen, J. Wengel, P. Nielsen, 1998 .

Stabilisation of a nucleic acid three-way junction by an oligonucleotide containing a single 2'-C to 3'-O-phosphate butylene linkage prepared by a tandem RCM-hydrogenation method.

P. Nielsen, Philip Børsting, K. E. Nielsen, 2005, Organic & biomolecular chemistry.

Dinucleotides of 4'-C-vinyl- and 5'-C-allylthymidine as substrates for ring-closing metathesis reactions

P. Nielsen, Claus Kirchhoff, 2003 .

A ring-closing metathesis strategy towards Conformationally restricted di-and trinucleotides

P. Nielsen, Philip Børsting, A. M. Sørensen, 2002 .

RING-CLOSING METATHESIS REACTIONS IN NUCLEIC ACID CHEMISTRY—CYCLIC DINUCLEOTIDES FOR TARGETING SECONDARY NUCLEIC ACID STRUCTURES

P. Nielsen, Philip B⊘rsting, 2005, Nucleosides, nucleotides & nucleic acids.

Analogues of a locked nucleic acid with three-carbon 2',4'-linkages: synthesis by ring-closing metathesis and influence on nucleic acid duplex stability and structure.

P. Nielsen, M. Petersen, Nanna Albaek, 2006, The Journal of organic chemistry.

LNA (Locked Nucleic Acids): Synthesis and High-Affinity Nucleic Acid Recognition.

Peter E. Nielsen, J. Wengel, P. Nielsen, 1998 .

A click chemistry approach to pleuromutilin conjugates with nucleosides or acyclic nucleoside derivatives and their binding to the bacterial ribosome.

L. H. Hansen, P. Nielsen, B. Vester, 2008, Journal of medicinal chemistry.

Synthesis of novel 3′-C-branched 2′-deoxynucleosides. Incorporation of 3′-C-(3-hydroxypropyl)thymidine into oligodeoxynucleotides

U. Sørensen, C. Olsen, J. Wengel, 1998 .

Parallel RNA-strand recognition by 2'-amino-beta-L-LNA.

J. Wengel, P. Nielsen, P. Sharma, 2009, Bioorganic & medicinal chemistry letters.

Incorporation of α- and β-LNA (Locked nucleic acid) monomers in oligodeoxynucleotides with polarity reversals

P. Nielsen, N. Christensen, B. Dahl, 2001 .

Allele-Selective Inhibition of Mutant Huntingtin with 2-Thio- and C5- Triazolylphenyl-Deoxythymidine-Modified Antisense Oligonucleotides.

P. Nielsen, P. Sharma, A. Watt, 2015, Nucleic acid therapeutics.

The Solution Structure of a DNA Duplex Containing a Single 1-(2-0,3-C-Ethylene-β-D Arabinofuranosyl)thymidine Nucleoside

J. Wengel, P. Nielsen, J. Jacobsen, 2000, Journal of biomolecular structure & dynamics.

Incorporation of (R)- and (S)-3',4'-seco-thymidine into oligodeoxynucleotides: hybridization properties and enzymatic stability.

J. Wengel, P. Nielsen, F. Kirpekar, 1994, Nucleic acids research.

Double-Headed 2'-Deoxynucleotides That Hybridize to DNA and RNA Targets via Normal and Reverse Watson-Crick Base Pairs.

P. Nielsen, Kasper M. Beck, 2022, The Journal of organic chemistry.

EVALUATION OF OLIGONUCLEOTIDES WITH NOVEL MODIFICATIONS

E. Pedersen, J. Wengel, P. Nielsen, 1995 .

The Extension of a DNA Double Helix by an Additional Watson–Crick Base Pair on the Same Backbone

P. Nielsen, Pawan Kumar, M. Petersen, 2013, Chembiochem : a European journal of chemical biology.

Additional base-pair formation in DNA duplexes by a double-headed nucleotide.

P. Nielsen, P. Sharma, Pawan Kumar, 2012, Chemistry.

Stabilisation of nucleic acid secondary structures by oligonucleotides with an additional nucleobase; synthesis and incorporation of 2'-deoxy-2'-C-(2-(thymine-1-yl)ethyl)uridine.

P. Nielsen, S. Pedersen, 2005, Organic & biomolecular chemistry.

SYNTHESIS AND EVALUATION OF NOVEL OLIGODEOXYNUCLEOTIDES CONTAINING 3'-C-(3-BENZOYLOXYPROPYL)THYMIDINE AND BICYCLO NUCLEOSIDE DERIVATIVES

J. Wengel, P. Nielsen, H. Pfundheller, 1997 .

Synthesis of A Branched Locked Nucleic Acid (LNA) Analogue

P. Nielsen, P. Sharma, Surender Kumar, 2007, Nucleosides, nucleotides & nucleic acids.

Synthesis of Novel 3′-C-Branched 2′-Deoxynucleosides. Incorporation of 3′-C-(3-Hydroxypropyl)thymidine into Oligodeoxynucleotides.

C. Olsen, J. Wengel, P. Nielsen, 1998 .

Synthesis of Nucleosides with Additional Nucleobases

P. Nielsen, Charlotte Andersen, S. Pedersen, 2007, Nucleosides, nucleotides & nucleic acids.

(1R,4R,7R,8R,9R)‐8‐Benzyloxy‐7‐benzyloxymethyl‐2,5,10‐trioxatricyclo[5.2.1.04,8]decan‐9‐ol

P. Nielsen, A. Bond, P. Sharma, 2007 .

NMR solution structure of dsDNA containing a bicyclic D-arabino-configured nucleotide fixed in an O4'-endo sugar conformation.

J. Wengel, P. Nielsen, J. Jacobsen, 2003, Organic & biomolecular chemistry.

Double-coding nucleic acids: introduction of a nucleobase sequence in the major groove of the DNA duplex using double-headed nucleotides.

P. Nielsen, P. Sharma, B. Vester, 2014, The Journal of organic chemistry.

Condensing the information in DNA with double-headed nucleotides.

P. Nielsen, P. Sharma, Pawan Kumar, 2017, Chemical communications.

Double-Headed Nucleotides: Building Blocks for New Nucleic Acid Architectures

P. Nielsen, P. Sharma, Pawan Kumar, 2016 .

Double-headed nucleotides introducing thymine nucleobases in the major groove of nucleic acid duplexes.

P. Nielsen, P. Sharma, Pawan Kumar, 2015, Organic & biomolecular chemistry.

Synthesis of 2′-O-(thymin-1-yl)methyluridine and its incorporation into secondary nucleic acid structures.

P. Nielsen, Pawan Kumar, C. Madsen, 2013, Bioorganic & medicinal chemistry letters.

Three pyrene-modified nucleotides: synthesis and effects in secondary nucleic acid structures.

P. Nielsen, Pawan Kumar, A. Jørgensen, 2012, The Journal of organic chemistry.

The synthesis of double-headed nucleosides by the CuAAC reaction and their effect in secondary nucleic acid structures.

P. Nielsen, A. Jørgensen, K. Shaikh, 2011, Organic & biomolecular chemistry.

Duplex and triplex formation of mixed pyrimidine oligonucleotides with stacking of phenyl-triazole moieties in the major groove.

P. Nielsen, F. Jensen, B. Vester, 2011, The Journal of organic chemistry.

Efficient RNA-targeting by the introduction of aromatic stacking in the duplex major groove via 5-(1-phenyl-1,2,3-triazol-4-yl)-2'-deoxyuridines.

P. Nielsen, F. Jensen, P. Sharma, 2010, Bioorganic & medicinal chemistry.

Synthesis of 5‐(1,2,3‐Triazol‐4‐yl)‐2′‐deoxyuridines by a Click Chemistry Approach: Stacking of Triazoles in the Major Groove Gives Increased Nucleic Acid Duplex Stability

P. Nielsen, F. Jensen, N. K. Andersen, 2007, Chembiochem : a European journal of chemical biology.

One- and two-photon solvatochromism of the fluorescent dye Nile Red and its CF_3, F and Br-substituted analogues

M. Samoć, J. Kongsted, D. Wüstner, 2020, Photochemical and Photobiological Sciences.

Sulfonamide bearing oligonucleotides: simple synthesis and efficient RNA recognition.

P. Nielsen, P. Sharma, Navneet Chandak, 2012, Bioorganic & medicinal chemistry.

Tricyclic Nucleosides Derived from D‐Glucose. Synthesis and Conformational Behavior.

P. Nielsen, J. Jacobsen, M. Petersen, 2001 .

Nucleobase-modified antisense oligonucleotides containing 5-(phenyltriazol)-2′-deoxyuridine nucleotides induce exon-skipping in vitro

P. Nielsen, P. Sharma, R. Veedu, 2017 .

A click chemistry approach to pleuromutilin derivatives, part 2: conjugates with acyclic nucleosides and their ribosomal binding and antibacterial activity.

L. H. Hansen, J. Kongsted, P. Nielsen, 2012, Journal of medicinal chemistry.

Synthesis of double-headed nucleosides with the additional nucleobase in the 5'-C-position.

Mikkel S. Christensen, P. Nielsen, P. Sharma, 2008, Nucleic acids symposium series.

Increasing the Stability of DNA:RNA Duplexes by Introducing Stacking Phenyl-Substituted Pyrazole, Furan, and Triazole Moieties in the Major Groove.

P. Nielsen, Pawan Kumar, M. Hornum, 2015, The Journal of organic chemistry.

Synthesis of functionalized carbocyclic locked nucleic acid analogues by ring-closing diene and enyne metathesis and their influence on nucleic acid stability and structure.

P. Nielsen, Marianne H. S. Hansen, M. Petersen, 2009, The Journal of organic chemistry.