D. Chandler

发表

RNA Splicing and Disease: Animal Models to Therapies.

Brianne L. Sanford, Matías Montes, Daniel F. Comiskey, 2019, Trends in genetics : TIG.

NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma.

Huating Wang, A. Cheng, C. Croce, 2008, Cancer cell.

Regulation of photoreceptor gene transcription via a highly conserved transcriptional regulatory element by vsx gene products

Daniel F. Comiskey, D. Chandler, Yi-Wun Pan, 2016, Molecular vision.

DEAR1 is a chromosome 1p35 tumor suppressor and master regulator of TGF-β-driven epithelial-mesenchymal transition.

Yu Cao, S. Sen, I. Wistuba, 2013, Cancer discovery.

Modeling Spinal Muscular Atrophy in Mouse: A Disease of Splicing, Stability, and Timing

T. Bebee, D. Chandler, 2011 .

Splice-switching of the insulin receptor in rhabdomyosarcoma: Rescuing the IR-B isoform for better treatment options

P. Houghton, F. Rigo, Matías Montes, 2020, bioRxiv.

The Role of the Insulin Receptor Isoforms in the Insulin-Like Growth Factor Signaling Axis in Cancer

Brianne L. Sanford, D. Chandler, 2022 .

Apoptosis and expression of the bcl-2 proto-oncogene in the fetal and adult human kidney: evidence for the contribution of bcl-2 expression to renal carcinogenesis.

T. McDonnell, D. Chandler, R. Redline, 1994, Human pathology.

Mouse models of SMA: tools for disease characterization and therapeutic development

T. Bebee, D. Chandler, Catherine E. Dominguez, 2012, Human Genetics.

Generation of a tamoxifen inducible SMN mouse for temporal SMN replacement

T. Bebee, D. Chandler, J. Gladman, 2011, Genesis.

Autoregulation of transformer-2 alternative splicing is necessary for normal male fertility in Drosophila.

B. Dauwalder, D. Chandler, W. Mattox, 1998, Genetics.

Leveraging gene therapy to achieve long-term continuous or controllable expression of biotherapeutics

E. Mardis, V. Magrini, J. Mendell, 2022, Science advances.

Alternatively Spliced Landscape of PPARγ mRNA in Podocytes Is Distinct from Adipose Tissue

Alexander S. Banks, S. Agrawal, D. Chandler, 2022, bioRxiv.

NF-κ B – YY 1 – miR-29 Regulatory Circuitry in Skeletal Myogenesis and Rhabdomyosarcoma

A. Cheng, C. Croce, R. Garzon, 2008 .

DEAR1 Is a Dominant Regulator of Acinar Morphogenesis and an Independent Predictor of Local Recurrence-Free Survival in Early-Onset Breast Cancer

K. Hunt, S. Sen, T. Buchholz, 2009, PLoS medicine.

Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4.

G. Lozano, D. Chandler, L. Caldwell, 2006, Cancer research.

Conserved sequences in the final intron of MDM2 are essential for the regulation of alternative splicing of MDM2 in response to stress.

T. Bebee, D. Chandler, Ravi K. Singh, 2009, Experimental cell research.

Alternative RNA Splicing Defects in Pediatric Cancers: New Insights in Tumorigenesis and Potential Therapeutic Vulnerabilities.

D. Chandler, T. Cripe, E. Mardis, 2022, Annals of oncology : official journal of the European Society for Medical Oncology.

Splicing factor SRSF1 negatively regulates alternative splicing of MDM2 under damage

Daniel F. Comiskey, D. Chandler, Aishwarya G. Jacob, 2015, Nucleic acids research.

Splicing factor SRSF 1 negatively regulates alternative splicing of MDM 2 under damage

Daniel F. Comiskey, D. Chandler, Aishwarya G. Jacob, 2015 .

SRSF2 Regulation of MDM2 Reveals Splicing as a Therapeutic Vulnerability of the p53 Pathway

Matías Montes, Daniel F. Comiskey, D. Chandler, 2019, Molecular Cancer Research.

A novel mouse model of rhabdomyosarcoma underscores the dichotomy of MDM2-ALT1 function in vivo

T. Bebee, Brianne L. Sanford, K. L. La Perle, 2017, Oncogene.

Stress-Induced Alternative Splice Forms of MDM2 and MDMX Modulate the p53-Pathway in Distinct Ways

T. Bebee, Daniel F. Comiskey, D. Chandler, 2014, PloS one.

The Splicing Factor FUBP1 Is Required for the Efficient Splicing of Oncogene MDM2 Pre-mRNA*

T. Bebee, D. Chandler, Fuad Mohammad, 2014, The Journal of Biological Chemistry.

Stress-induced isoforms of MDM2 and MDM4 correlate with high-grade disease and an altered splicing network in pediatric rhabdomyosarcoma.

James R. Anderson, Daniel F. Comiskey, D. Chandler, 2013, Neoplasia.

Advances in pediatric rhabdomyosarcoma characterization and disease model development.

D. Chandler, S. Qualman, A. Jacob, 2012, Histology and histopathology.

MDM2 and MDM4 splicing: an integral part of the cancer spliceome.

D. Chandler, Selvi C. Jeyaraj, D. O'Brien, 2009, Frontiers in bioscience.

Functionally antagonistic sequences are required for normal autoregulation of Drosophila tra-2 pre-mRNA splicing.

D. Chandler, W. Mattox, M. McGuffin, 2001, Nucleic acids research.

SMN regulation in SMA and in response to stress: new paradigms and therapeutic possibilities

D. Chandler, Catherine E. Dominguez, D. Cunningham, 2017, Human Genetics.

Mouse models of SMA: tools for disease characterization and therapeutic development

T. Bebee, D. Chandler, Catherine E. Dominguez, 2012, Human Genetics.

Modeling the human MTM1 p.R69C mutation in murine Mtm1 results in exon 4 skipping and a less severe myotubular myopathy phenotype.

J. Dowling, A. Beggs, D. Chandler, 2012, Human molecular genetics.

Direct Repression of Splicing by transformer-2

Junlin Qi, D. Chandler, W. Mattox, 2003, Molecular and Cellular Biology.

Heat increases full-length SMN splicing: promise for splice-augmenting therapies for SMA

D. Chandler, Catherine E. Dominguez, D. Cunningham, 2022, Human Genetics.

Hypoxia is a modifier of SMN2 splicing and disease severity in a severe SMA mouse model.

T. Bebee, D. Chandler, Catherine E. Dominguez, 2012, Human molecular genetics.

A humanized Smn gene containing the SMN2 nucleotide alteration in exon 7 mimics SMN2 splicing and the SMA disease phenotype.

T. Bebee, M. Rich, D. Chandler, 2010, Human molecular genetics.

Splicing regulation of the survival motor neuron genes and implications for treatment of spinal muscular atrophy.

T. Bebee, D. Chandler, J. Gladman, 2010 .

Splicing of the Survival Motor Neuron genes and implications for treatment of SMA

T. Bebee, D. Chandler, J. Gladman, 2010, Frontiers in bioscience.

Intron 7 conserved sequence elements regulate the splicing of the SMN genes

D. Chandler, J. Gladman, 2009, Human Genetics.

Evolutionary conservation of regulatory strategies for the sex determination factor transformer-2

B. S. Baker, J. Piškur, D. Chandler, 1997, Molecular and cellular biology.

Splice-switching of the insulin receptor pre-mRNA alleviates tumorigenic hallmarks in rhabdomyosarcoma

P. Houghton, F. Rigo, Matías Montes, 2022, npj Precision Oncology.

High frequency loss of heterozygosity in von Hippel-Lindau (VHL)-associated and sporadic pancreatic islet cell tumors: evidence for a stepwise mechanism for malignant conversion in VHL tumorigenesis.

S. Curley, L. Strong, M. Frazier, 2002, Cancer research.

miR-29 Acts as a Decoy in Sarcomas to Protect the Tumor Suppressor A20 mRNA from Degradation by HuR

C. Croce, C. Keller, P. Houghton, 2013, Science Signaling.

Erratum: miR-29 acts as a decoy in sarcomas to protect the tumor suppressor A20 mRNA from degradation by HuR (Science Signaling (2013) 6 (er6))

C. Croce, C. Keller, P. Houghton, 2013 .

Advances in Brief High Frequency Loss of Heterozygosity in von Hippel-Lindau ( VHL )-associated and Sporadic Pancreatic Islet Cell Tumors : Evidence for a Stepwise Mechanism for Malignant Conversion in VHL Tumorigenesis 1

S. Curley, L. Strong, M. Frazier, 2002 .

Supplemental Data Article NF-κB-YY1-miR-29 Regulatory Circuitry in Skeletal Myogenesis and Rhabdomyosarcoma

A. Cheng, C. Croce, R. Garzon, 2007 .

Essential role of c-mos in eggs: Reduced fertility and ovarian neoplasm in antisense mos transgenic mice

S. Rajagopalan, D. Chandler, Balraj Singh, 1997 .

DEAR1 is a chromosome 1p35 tumor suppressor and master regulator of TGF-β-driven epithelial-mesenchymal transition.

Yu Cao, S. Sen, I. Wistuba, 2013, Cancer discovery.