I. Okazaki

发表

Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium

Takeshi Azuma, Tasuku Honjo, Kazuo Kinoshita, 2007, Nature Medicine.

Stimulatory and Inhibitory Co-signals in Autoimmunity.

T. Okazaki, I. Okazaki, Taku Okazaki, 2019, Advances in experimental medicine and biology.

PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice

T. Okazaki, T. Honjo, M. Muramatsu, 2011, The Journal of experimental medicine.

Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity.

T. Okazaki, N. Ishimaru, I. Okazaki, 2022, Immunity.

LAG-3: from molecular functions to clinical applications

T. Okazaki, I. Okazaki, D. Sugiura, 2020, Journal for ImmunoTherapy of Cancer.

Identification of QTLs that modify peripheral neuropathy in NOD.H2b-Pdcd1-/- mice.

T. Okazaki, T. Honjo, I. Okazaki, 2009, International immunology.

PD-1 agonism by anti-CD80 inhibits T cell activation and alleviates autoimmunity

T. Okazaki, N. Ishimaru, I. Okazaki, 2022, Nature Immunology.

Single-cell level temporal profiling of tumour-reactive T cells under immune checkpoint blockade

T. Okazaki, I. Okazaki, B. J. Tan, 2022, bioRxiv.

PD-1 deficiency results in the development of fatal myocarditis in MRL mice.

T. Okazaki, T. Honjo, I. Okazaki, 2010, International immunology.

LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII

T. Okazaki, I. Okazaki, D. Sugiura, 2018, Nature Immunology.

PD-1 preferentially inhibits the activation of low-affinity T cells

T. Okazaki, I. Okazaki, D. Sugiura, 2021, Proceedings of the National Academy of Sciences.

PD-1 Imposes Qualitative Control of Cellular Transcriptomes in Response to T Cell Activation.

T. Okazaki, I. Okazaki, D. Sugiura, 2019, Molecular cell.

Glucocorticoids potentiate the inhibitory capacity of programmed cell death 1 by up-regulating its expression on T cells

T. Okazaki, I. Okazaki, D. Sugiura, 2019, The Journal of Biological Chemistry.

PD-1 efficiently inhibits T cell activation even in the presence of co-stimulation through CD27 and GITR.

T. Okazaki, I. Okazaki, D. Sugiura, 2019, Biochemical and biophysical research communications.

PD-1 ef fi ciently inhibits T cell activation even in the presence of co-stimulation through CD 27 and GITR

T. Okazaki, I. Okazaki, D. Sugiura, 2019 .

Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation

T. Okazaki, I. Okazaki, D. Sugiura, 2019, The Journal of Biological Chemistry.

Inhibitory mechanisms of LAG-3-dependent T cell suppression Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation

T. Okazaki, I. Okazaki, D. Sugiura, 2019 .

Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses

T. Okazaki, I. Okazaki, D. Sugiura, 2019, Science.

A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression.

T. Honjo, M. Muramatsu, K. Kinoshita, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Constitutive Expression of AID Leads to Tumorigenesis

N. Kakazu, T. Honjo, M. Muramatsu, 2003, The Journal of experimental medicine.

Expression of activation‐induced cytidine deaminase in human hepatocytes during hepatocarcinogenesis

K. Kinoshita, H. Marusawa, Y. Endo, 2007, International journal of cancer.

Role of AID in tumorigenesis.

T. Honjo, I. Okazaki, A. Kotani, 2007, Advances in immunology.

Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.

T. Honjo, R. Shinkura, Y. Nakabeppu, 2009, International immunology.

Molecular mechanism for generation of antibody memory

T. Honjo, R. Shinkura, K. Kinoshita, 2009, Philosophical Transactions of the Royal Society B: Biological Sciences.

The AID enzyme induces class switch recombination in fibroblasts

T. Honjo, M. Muramatsu, K. Kinoshita, 2002, Nature.

AID Enzyme-Induced Hypermutation in an Actively Transcribed Gene in Fibroblasts

T. Honjo, M. Muramatsu, K. Kinoshita, 2002, Science.

Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice

N. Kakazu, T. Honjo, M. Muramatsu, 2007, Proceedings of the National Academy of Sciences.

Expression of activation-induced cytidine deaminase in human hepatocytes via NF-κB signaling

T. Honjo, T. Sakurai, K. Kinoshita, 2007, Oncogene.

PD-1 aborts the activation trajectory of autoreactive CD8+ T cells to prohibit their acquisition of effector functions.

T. Okazaki, I. Okazaki, D. Sugiura, 2019, Journal of autoimmunity.

Organ‐specific profiles of genetic changes in cancers caused by activation‐induced cytidine deaminase expression

T. Honjo, H. Marusawa, T. Morisawa, 2008, International journal of cancer.

Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation

T. Honjo, R. Shinkura, Maki Kobayashi, 2011, Proceedings of the National Academy of Sciences.

Regulation of AID function in vivo.

T. Honjo, R. Shinkura, T. Muto, 2007, Advances in experimental medicine and biology.

Negative regulation of activation-induced cytidine deaminase in B cells.

Yoshimasa Tanaka, T. Honjo, T. Muto, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Activation‐Induced Cytidine Deaminase Links Class Switch Recombination and Somatic Hypermutation

M. Muramatsu, K. Kinoshita, I. Okazaki, 2003, Annals of the New York Academy of Sciences.

A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations

T. Honjo, K. Kinoshita, S. Yamada, 2009, Oncogene.

TRIM28 prevents autoinflammatory T cell development in vivo

T. Honjo, I. Okazaki, S. Chikuma, 2012, Nature Immunology.

Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE).

T. Okazaki, K. Mitsumori, M. Matsumoto, 2018, Journal of autoimmunity.

Successful Treatment of Immune Thrombocytopenia as an Extrahepatic Manifestation in an HCV-Carrier Woman with Normal Liver Function Test Results

I. Okazaki, Miyakawa, 2014 .

PD-1 Primarily Targets TCR Signal in the Inhibition of Functional T Cell Activation

T. Okazaki, I. Okazaki, D. Sugiura, 2019, Front. Immunol..

Title AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination

T. Honjo, R. Shinkura, M. Muramatsu, 2021 .

AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination

T. Honjo, R. Shinkura, M. Muramatsu, 2009, Proceedings of the National Academy of Sciences.

Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation

T. Honjo, R. Shinkura, Maki Kobayashi, 2011, Proceedings of the National Academy of Sciences.

LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII

I. Okazaki, D. Sugiura, K. Shimizu, 2018, Nature Immunology.