M. van de Wetering

发表

Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung.

S. Rodenhuis, J. Bos, N. van Zandwijk, 1987, The New England journal of medicine.

Origins of lymphatic and distant metastases in human colorectal cancer

Johannes G. Reiter, M. Nowak, S. Elledge, 2017, Science.

Single-cell dissection of transcriptional heterogeneity in human colon tumors

Pradeep S Rajendran, N. Neff, D. Sahoo, 2011, Nature Biotechnology.

The intestinal stem cell.

Hans Clevers, Nick Barker, Marc van de Wetering, 2008, Genes & development.

Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy

Mauro J. Muraro, A. van Oudenaarden, H. Clevers, 2018, Proceedings of the National Academy of Sciences.

All Tcf HMG box transcription factors interact with Groucho-related co-repressors.

H Clevers, M van De Wetering, H. Clevers, 2001, Nucleic acids research.

Genome-Wide Pattern of TCF7L2/TCF4 Chromatin Occupancy in Colorectal Cancer Cells

Hans Clevers, Edwin Cuppen, Victor Guryev, 2008, Molecular and Cellular Biology.

TCF/LEF factor earn their wings.

H Clevers, M van de Wetering, H. Clevers, 1997, Trends in genetics : TIG.

Highly sensitive proteome analysis of FACS-sorted adult colon stem cells.

H. Clevers, S. Mohammed, A. Heck, 2011, Journal of proteome research.

T lymphocytes: differential role for glycogen

H. Clevers, F. Staal, M. van de Wetering, 2022 .

Genomic organization of the segment polarity gene pan in Drosophila melanogaster

H. Clevers, M. van de Wetering, M. van Beest, 1998, Molecular and General Genetics MGG.

Wnt Activation and Alternative Promoter Repression of LEF1 in Colon Cancer

M. Waterman, M. van de Wetering, N. Yokoyama, 2006, Molecular and Cellular Biology.

Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors

M. Stratton, H. Clevers, J. Tabernero, 2022, Nature Cancer.

Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.

Hans Clevers, Nick Barker, Marc van de Wetering, 2010, Cell stem cell.

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

Hans Clevers, Johan H van Es, Marc van de Wetering, 2013, The EMBO journal.

FANTOM5 CAGE profiles of human and mouse samples

Jay W. Shin, Thomas J. Ha, Kelly J. Morris, 2017, Scientific Data.

Empagliflozin in the treatment of heart failure with reduced ejection fraction in addition to background therapies and therapeutic combinations (EMPEROR-Reduced): a post-hoc analysis of a randomised, double-blind trial.

José Miguel Contreras, G. Lip, J. De Sutter, 2021, The lancet. Diabetes & endocrinology.

Ectopic Wnt signal determines the eyeless phenotype of zebrafish masterblind mutant.

H Clevers, M van de Wetering, S van de Water, 2001, Development.

Mutant E-cadherin breast cancer cells do not display constitutive Wnt signaling.

H Clevers, M van de Wetering, N Barker, 2001, Cancer research.

Sox 15, a novel member of the murine Sox family of HMG box transcription factors.

H. Clevers, M. van de Wetering, 1993, Nucleic acids research.

Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties

H Clevers, V Korinek, H. Clevers, 1996, Molecular and cellular biology.

The Schizosaccharomyces pombe mating-type gene mat-Mc encodes a sequence-specific DNA-binding high mobility group box protein.

H. Clevers, M. van de Wetering, D. Dooijes, 1993, The Journal of biological chemistry.

Clonal acquisition of the Ly49A NK cell receptor is dependent on the trans-acting factor TCF-1.

H Clevers, M van de Wetering, W Held, 1999, Immunity.

Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors

Hans Clevers, Barbara Lustig, Boris Jerchow, 2002, Molecular and Cellular Biology.

Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas

Hans Clevers, Marc van de Wetering, H. Clevers, 2012, Science.

Xenograft and organoid model systems in cancer research

H. Clevers, J. Drost, M. van de Wetering, 2019, The EMBO journal.

Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer.

Hans Clevers, Albert J R Heck, Shabaz Mohammed, 2017, Cell reports.

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

Hans Clevers, David A Egan, Marc van de Wetering, 2016, eLife.

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases

Hans Clevers, Marc van de Wetering, Marlous Hoogstraat, 2015, Proceedings of the National Academy of Sciences.

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

Hans Clevers, Nobuo Sasaki, Edwin Cuppen, 2015, Cell.

In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection.

Hans Clevers, Marc van de Wetering, Harry Begthel, 2015, Gastroenterology.

Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs.

H Clevers, M van Beest, D Dooijes, 2000, The Journal of biological chemistry.

Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis.

Eugene Berezikov, Edwin Cuppen, Victor Guryev, 2006, Genome research.

Efficient Double Fragmentation ChIP-seq Provides Nucleotide Resolution Protein-DNA Binding Profiles

Hans Clevers, Edwin Cuppen, Victor Guryev, 2010, PloS one.

Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion

A. van Oudenaarden, H. Clevers, K. Wiebrands, 2019, Proceedings of the National Academy of Sciences.

Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Martin S. Taylor, Jay W. Shin, Thomas J. Ha, 2021, Nature Communications.

The Lgr5 Intestinal Stem Cell Signature: Robust Expression of Proposed Quiescent ' Þ 4' Cell Markers

Alexander van Oudenaarden, Hans Clevers, Jan Koster, 2022 .

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.

Hans Clevers, Eduard Batlle, Elena Sancho, 2002, Cell.

OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells.

Hans Clevers, Marc van de Wetering, H. Clevers, 2009, Gastroenterology.

ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response.

H. Clevers, D. Hommes, M. Wetering, 2013, Cell reports.

β-Catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation

Hans Clevers, Walter Birchmeier, Marc van de Wetering, 2003, Development.

DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus

G. Hannon, R. Ketting, H. Clevers, 2013, Genome Biology.

SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes

Hans Clevers, Marc van de Wetering, Philippe Blache, 2004, The Journal of cell biology.

Frequent loss of the AXIN1 locus but absence of AXIN1 gene mutations in adenocarcinomas of the gastro-oesophageal junction with nuclear β-catenin expression

A. V. D. van den Ouweland, W. Dinjens, M. van de Wetering, 2004, British Journal of Cancer.

Differential expression of the HMG box factors TCF-1 and LEF-1 during murine embryogenesis.

H Clevers, O Destree, M van de Wetering, 1993, Development.

Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers

H Clevers, K Georgopoulos, D Dooijes, 1991, The Journal of experimental medicine.

Cyclin D1 Is Not an Immediate Target of β-Catenin following Apc Loss in the Intestine*

H. Clevers, O. Sansom, D. Winton, 2005, Journal of Biological Chemistry.

Specific inhibition of gene expression using a stably integrated, inducible small‐interfering‐RNA vector

F. Holstege, R. Agami, H. Clevers, 2003, EMBO reports.

Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer.

Hans Clevers, Marc van de Wetering, Elles M J Boon, 2002, Cancer research.

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

A. van Oudenaarden, H. Clevers, D. Spierings, 2019, Nature Genetics.

Lgr5 intestinal stem cells have high telomerase activity and randomly segregate their chromosomes

H. Clevers, R. Vries, Maaike van den Born, 2011, The EMBO journal.

Aberrant Polycystin-1 Expression Results in Modification of Activator Protein-1 Activity, whereas Wnt Signaling Remains Unaffected*

Marc van de Wetering, Ngoc Hang Le, Paola van der Bent, 2004, Journal of Biological Chemistry.

The Intestinal Wnt/TCF Signature.

H. Clevers, Laurens G. van der Flier, A. Haegebarth, 2007, Gastroenterology.

Single-cell dissection of transcriptional heterogeneity in human colon tumors

N. Neff, D. Sahoo, S. Quake, 2011, Nature Biotechnology.

Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2

A. van Oudenaarden, H. Clevers, L. Kester, 2014, Nature Communications.

The inner nuclear membrane protein Emerin regulates β‐catenin activity by restricting its accumulation in the nucleus

Juliet A. Ellis, H. Clevers, N. Barker, 2006, The EMBO journal.

Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

H. Clevers, M. Kasper, N. Barker, 2010, Science.

Lack of effects of emulsified propofol ('Diprivan') on vecuronium pharmacodynamics--preliminary results in man.

J. van Egmond, M. van de Wetering, L. Booij, 1985, Postgraduate medical journal.

Wnt Activates the Tak1/Nemo-like Kinase Pathway*

H. Korswagen, H. Clevers, J. Kuipers, 2004, Journal of Biological Chemistry.

Lgr5(+ve) stem/progenitor cells contribute to nephron formation during kidney development.

H. Clevers, R. Poulsom, P. Kujala, 2012, Cell reports.

HMG box proteins in early T-cell differentiation.

H. Clevers, M. van de Wetering, M. Oosterwegel, 1993, Thymus.

The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization.

F. Holstege, H. Clevers, M. van de Wetering, 1992, The Journal of biological chemistry.

Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype

T. Margaritis, F. Holstege, H. Clevers, 2021, Proceedings of the National Academy of Sciences.

EWSR1-WT1 Target Genes and Therapeutic Options Identified in a Novel DSRCT In Vitro Model

H. Clevers, M. van de Wetering, F. Meyer-Wentrup, 2021, Cancers.

Identification of primary MAFB target genes in multiple myeloma.

H. Clevers, A. Neri, M. van de Wetering, 2009, Experimental hematology.

properties . isoforms with differential transcription control promoter usage generate Tcf-1 protein Extensive alternative splicing and dual

H. Clevers, M. van de Wetering, J. Castrop, 1996 .

Lrig1 controls intestinal stem cell homeostasis by negative regulation of ErbB signalling

Hans Clevers, Nicholas A. Wright, Satoshi Itami, 2012, Nature Cell Biology.

Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development

L. Kiemeney, H. Clevers, I. Nagtegaal, 2015, The Journal of pathology.

TCF-1, a T cell-specific transcription factor of the HMG box family, interacts with sequence motifs in the TCR beta and TCR delta enhancers.

H C Clevers, M A Oosterwegel, M L van de Wetering, 1991, International immunology.

The murine Sox-4 protein is encoded on a single exon.

H C Clevers, M W Schilham, M van Eijk, 1993, Nucleic acids research.

The sequence-specific high mobility group 1 box of TCF-1 adopts a predominantly alpha-helical conformation in solution.

H Clevers, D Dooijes, M van de Wetering, 1993, The Journal of biological chemistry.

MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms.

H. Clevers, M. van de Wetering, M. Spaargaren, 2017, Gastroenterology.

Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes

P. Kemmeren, Mariël Brok, F. Holstege, 2022, bioRxiv.

Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities

M. Roussel, M. Kool, H. Clevers, 2023, Oncogene.

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

S. Itzkovitz, A. van Oudenaarden, H. Clevers, 2022 .

Sequential cancer mutations in cultured human intestinal stem cells

Hans Clevers, Edwin Cuppen, Geert J. P. L. Kops, 2015, Nature.

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

Hans Clevers, Bon-Kyoung Koo, Marc van de Wetering, 2011, Nature.

FANTOM5 CAGE profiles of human and mouse samples.

Jay W. Shin, Thomas J. Ha, Kelly J. Morris, 2017, Scientific data.

Multi-dimensional profiling of hepatoblastomas and patient-derived tumor organoids uncovers tumor subpopulations with divergent WNT activation profiles and identifies pan-hepatoblastoma drug sensitivities

T. Margaritis, P. Lijnzaad, H. Clevers, 2023, bioRxiv.

Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro.

H. Clevers, R. Poulsom, P. Kujala, 2010, Cell stem cell.

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

S. Itzkovitz, A. van Oudenaarden, H. Clevers, 2012, The EMBO journal.

OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells.

H. Clevers, Laurens G. van der Flier, A. Haegebarth, 2009, Gastroenterology.

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

S. Itzkovitz, A. van Oudenaarden, H. Clevers, 2012, The EMBO journal.

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

A. van Oudenaarden, H. Clevers, D. Spierings, 2019, Nature Genetics.

Germline deletions in the tumour suppressor gene FOCAD are associated with polyposis and colorectal cancer development

L. Kiemeney, H. Clevers, I. Nagtegaal, 2015, The Journal of pathology.

Unbiased transcription factor CRISPR screen identifies ZNF800 as master repressor of enteroendocrine differentiation

T. Margaritis, J. Korving, H. Begthel, 2023, Science.

Identification of two novel regulated serines in the N terminus of beta-catenin.

Hans Clevers, Mascha van Noort, Marc van de Wetering, 2002, Experimental cell research.

Genome-Wide Pattern of TCF7L2/TCF4 Chromatin Occupancy in Colorectal Cancer Cells

Fiona G. G. Nielsen, H. Stunnenberg, E. Cuppen, 2008, Molecular and Cellular Biology.

Ewing Sarcoma Single-cell Transcriptome Analysis Reveals Functionally Impaired Antigen-presenting Cells

T. Margaritis, F. Holstege, M. van de Wetering, 2023, Cancer research communications.