P. Roach

发表

An analysis of the feasibility of short read sequencing

Niall J. Haslam, C. Neylon, J. Essex, 2005, Nucleic acids research.

X-ray crystal structure of Escherichia coli taurine/alpha-ketoglutarate dioxygenase complexed to ferrous iron and substrates.

J. Elkins, M. J. Ryle, R. Hausinger, 2002, Biochemistry.

Product inhibition in the radical S‐adenosylmethionine family

P. Roach, T. Ziegert, M. R. Challand, 2009, FEBS letters.

Whole genome transcriptomics reveals global effects including up-regulation of Francisella pathogenicity island gene expression during active stringent response in the highly virulent Francisella tularensis subsp. tularensis SCHU S4

P. Skipp, P. Roach, P. Oyston, 2017, Microbiology.

Cysteine Methylation Controls Radical Generation in the Cfr Radical AdoMet rRNA Methyltransferase

P. Roach, E. Salvadori, J. Spencer, 2013, PloS one.

The Black Sea in crisis.

V. Robinson, P. Roach, R. Titball, 1997, Environmental health perspectives.

Multiplexed suspension array platform for high-throughput protein assays

P. Roach, H. Morgan, G. R. Broder, 2012, Biomedical microdevices.

Colloidal SERS sensors for inflammatory biomarker detection in urine for patient risk stratification

P. Roach, W. Anderson, S. Mahajan, 2021 .

Kinetic Analysis of Yersinia pestis DNA Adenine Methyltransferase Activity Using a Hemimethylated Molecular Break Light Oligonucleotide

V. Robinson, P. Roach, R. Titball, 2007, PloS one.

A device for the high-pressure oxygenation of protein crystals.

J. Elkins, P. Roach, P. Rutledge, 2002, Analytical biochemistry.

Colloidal SERS sensors for inflammatory biomarker detection in urine for patient risk stratification

P. Roach, W. Anderson, S. Mahajan, 2021 .

The Rhodanese Domain of ThiI Is Both Necessary and Sufficient for Synthesis of the Thiazole Moiety of Thiamine in Salmonella enterica

P. Roach, L. Palmer, D. Downs, 2011, Journal of bacteriology.

Peptide mapping of the active site of Bacillus cereusβ-lactamase I by the use of high pressure liquid chromatography coupled to electrospray ionisation mass spectrometry

C. Robinson, P. Roach, C. Schofield, 1994 .

Development of rationally designed DNA N6 adenine methyltransferase inhibitors.

P. Roach, P. Oyston, J. Harmer, 2012, Bioorganic & medicinal chemistry letters.

X-ray crystallographic and EPR spectroscopic analysis of HydG, a maturase in [FeFe]-hydrogenase H-cluster assembly

J. Essex, P. Roach, R. D. Britt, 2015, Proceedings of the National Academy of Sciences.

Radical S-adenosylmethionine enzymes: mechanism, control and function.

P. Roach, M. R. Challand, Rebecca C. Driesener, 2011, Natural product reports.

Radicals from S-adenosylmethionine and their application to biosynthesis.

P. Roach, 2011, Current opinion in chemical biology.

High-level expression and reconstitution of active Cfr, a radical-SAM rRNA methyltransferase that confers resistance to ribosome-acting antibiotics.

P. Roach, J. Spencer, M. R. Challand, 2010, Protein expression and purification.

The activity of a thermostable lipoyl synthase from Sulfolobus solfataricus with a synthetic octanoyl substrate.

P. Roach, R. J. Wood, M. Kriek, 2006, Analytical biochemistry.

Structural studies on the reaction of isopenicillin N synthase with the substrate analogue δ -( L - α -aminoadipoyl)- L -cysteinyl- D - α -aminobutyrate

P. Roach, C. Schofield, P. Rutledge, 2003 .

Metallocofactor assembly for [FeFe]-hydrogenases.

P. Roach, Beata M Wieckowski, P. Dinis, 2016, Current opinion in structural biology.

The iron-sulfur center of biotin synthase: site-directed mutants

M. Fontecave, P. Roach, K. Hewitson, 2001, JBIC Journal of Biological Inorganic Chemistry.

Biochemical studies on Francisella tularensis RelA in (p)ppGpp biosynthesis

P. Roach, Neil J Wells, P. Oyston, 2015, Bioscience reports.

[FeFe]-hydrogenase cyanide ligands derived from S-adenosylmethionine-dependent cleavage of tyrosine.

J. W. Peters, E. Boyd, P. Roach, 2010, Angewandte Chemie.

Thiamine biosynthesis in Escherichia coli: identification of the intermediate and by-product derived from tyrosine.

P. Roach, M. R. Challand, M. Kriek, 2007, Angewandte Chemie.

Radical S-Adenosylmethionine Enzymes: Mechanism, Control and Function

P. Roach, M. R. Challand, Rebecca C. Driesener, 2011 .

Structures of lipoyl synthase reveal a compact active site for controlling sequential sulfur insertion reactions.

J. Essex, P. Roach, S. Fox, 2014, The Biochemical journal.

Crystallization and preliminary X‐ray diffraction studies on recombinant isopenicillin N synthase from Aspergillus nidulans

J. Hajdu, P. Roach, C. Schofield, 1995, Protein science : a publication of the Protein Society.

Catalytic Activity of the Anaerobic Tyrosine Lyase Required for Thiamine Biosynthesis in Escherichia coli*

P. Roach, M. R. Challand, F. Martins, 2009, The Journal of Biological Chemistry.

Thiazole Synthase from Escherichia coli

P. Roach, S. Fairhurst, D. Lowe, 2007, Journal of Biological Chemistry.

[FeFe]-hydrogenase maturation: HydG-catalyzed synthesis of carbon monoxide.

J. W. Peters, P. Roach, J. Broderick, 2010, Journal of the American Chemical Society.

Thiamine Biosynthesis in Escherichia coli

P. Roach, Roberta Leonardi, 2004, Journal of Biological Chemistry.

Biochemistry: Suicide of a protein

P. Roach, 2011, Nature.

Lipoyl synthase inserts sulfur atoms into an octanoyl substrate in a stepwise manner.

P. Roach, Paul Douglas, M. Kriek, 2006, Angewandte Chemie.

Thiamine biosynthesis in Escherichia coli: isolation and initial characterisation of the ThiGH complex

P. Roach, S. Fairhurst, M. Kriek, 2003, FEBS letters.

Optimized conjugation of a fluorescent label to proteins via intein-mediated activation and ligation.

C. Neylon, P. Roach, R. J. Wood, 2004, Bioconjugate chemistry.

Effect of iron-sulfur cluster assembly proteins on the expression of Escherichia coli lipoic acid synthase.

P. Roach, M. Kriek, Y. Takahashi, 2003, Protein expression and purification.

MioC Is an FMN-binding Protein That Is Essential forEscherichia coli Biotin Synthase Activity in Vitro *

P. Roach, K. Hewitson, J. Baldwin, 2000, The Journal of Biological Chemistry.

The reaction cycle of isopenicillin N synthase observed by X-ray diffraction

P. Roach, P. Rutledge, N. Burzlaff, 1999, Nature.

Structure of isopenicillinN synthase complexed with substrate and the mechanism ofpenicillin formation

J. Hajdu, P. Roach, C. Schofield, 1997, Nature.

A base labile protecting group for peptide synthesis: 2,2 -Bis(4′-nitrophenyl)ethan-1-oxycarbonyl urethanes

A. J. Blake, P. Roach, A. Blake, 1991 .

Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes

Geoffrey J. Barton, Peter L. Roach, Christopher J. Schofield, 1995, Nature.

Structure of a specific acyl-enzyme complex formed between β-casomorphin-7 and porcine pancreatic elastase

J. Hajdu, C. Robinson, N. Westwood, 1997, Nature Structural Biology.

Interactions of isopenicillin N synthase with cyclopropyl-containing substrate analogues reveal new mechanistic insight.

J. Elkins, P. Roach, P. Rutledge, 2007, Biochemistry.

Substrate recognition and mechanism revealed by ligand-bound polyphosphate kinase 2 structures

P. Roach, S. Gerhardt, O. Einsle, 2018, Proceedings of the National Academy of Sciences.

A real-time assay for CpG-specific cytosine-C5 methyltransferase activity

P. Roach, R. J. Wood, Michael D. Maynard-Smith, 2010, Nucleic acids research.

Biochemical and kinetic characterization of radical S-adenosyl-L-methionine enzyme HydG.

J. W. Peters, P. Roach, J. Broderick, 2013, Biochemistry.

Biochemical and kinetic characterization of radical AdoMet enzyme HydG

J. W. Peters, P. Roach, J. Broderick, 2022 .

Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.

J. Hajdu, P. Roach, C. Schofield, 1997, Nature.

Bead-based immunoassays using a micro-chip flow cytometer.

Hywel Morgan, D. Holmes, P. Roach, 2007, Lab on a chip.

Proteins of the penicillin biosynthesis pathway.

J. Hajdu, P. Roach, C. Schofield, 1997, Current opinion in structural biology.

Studies on non-haem ferrous-dependent oxygenases and oxidases.

M. D. Lloyd, J. Hajdu, P. Roach, 1997, Biochemical Society transactions.

Iron-sulfur center of biotin synthase and lipoate synthase.

M. Fontecave, P. Roach, P. Roach, 2000, Biochemistry.

Kinetics and thermodynamics of biotinylated oligonucleotide probe binding to particle-immobilized avidin and implications for multiplexing applications.

C. Neylon, P. Roach, H. Morgan, 2011, Analytical chemistry.

Anaerobic crystallisation of an isopenicillin N synthase.Fe(II).substrate complex demonstrated by X-ray studies.

J. Hajdu, R. Strange, P. Roach, 1996, European journal of biochemistry.

Crystallographic studies on the reaction of isopenicillin N synthase with an unsaturated substrate analogue.

J. Elkins, P. Roach, P. Rutledge, 2003, Organic & biomolecular chemistry.

Alternative oxidation by isopenicillin N synthase observed by X-ray diffraction.

J. Elkins, P. Roach, J. M. Ogle, 2001, Chemistry & biology.

Direct and continuous fluorescence-based measurements of Pyrococcus horikoshii DNA N-6 adenine methyltransferase activity.

P. Roach, R. J. Wood, Rohan T. Ranasinghe, 2011, Analytical biochemistry.

Enzyme catalyzed formation of radicals from S-adenosylmethionine and inhibition of enzyme activity by the cleavage products.

P. Roach, Rebecca C. Driesener, Martyn J. Hiscox, 2012, Biochimica et biophysica acta.

Mutagenesis of the proposed iron‐sulfur cluster binding ligands in Escherichia coli biotin synthase

P. Roach, K. Hewitson, J. Baldwin, 2000, FEBS letters.

Thin film polycrystalline silicon nanowire biosensors.

Kai Sun, Hywel Morgan, Peter Ashburn, 2012, Nano letters.

Biochemical and structural characterization of polyphosphate kinase 2 from the intracellular pathogen Francisella tularensis

P. Roach, Neil J Wells, P. Oyston, 2015, Bioscience reports.

Reductive Cleavage of S-Adenosylmethionine by Biotin Synthase from Escherichia coli *

M. Fontecave, P. Roach, K. Hewitson, 2002, The Journal of Biological Chemistry.

Investigations into the post-translational modification and mechanism of isopenicillin N:acyl-CoA acyltransferase using electrospray mass spectrometry.

C. Robinson, P. Roach, C. Schofield, 1993, The Biochemical journal.

Synthesis of peptides by the solid phase method

P. Roach, 1990 .

A simple setup for the study of microvolume frozen samples using Raman spectroscopy

Cameron Neylon, Anthony W. Parker, Peter L. Roach, 2005 .

Observation of the iron-sulfur cluster in Escherichia coli biotin synthase by nanoflow electrospray mass spectrometry.

C. Robinson, P. Roach, K. Hewitson, 2001, Analytical chemistry.

[FeFe]-hydrogenase cyanide ligands derived from S-adenosylmethionine-dependent cleavage of tyrosine.

J. W. Peters, E. Boyd, P. Roach, 2010, Angewandte Chemie.

Kinetic Analysis of Yersinia pestis DNA Adenine Methyltransferase Activity Using a Hemimethylated Molecular Break Light Oligonucleotide

V. Robinson, P. Roach, R. Titball, 1997, Environmental health perspectives.