Z. Sauna

发表

Supporting Online Material Materials and Methods Som Text Figs. S1 to S8 Table S1 Movies S1 to S3 a " Silent " Polymorphism in the Mdr1 Gene Changes Substrate Specificity Corrected 30 November 2007; See Last Page

Lippincott-Schwartz, M. Gottesman, E. Elson, 2022 .

Understanding the contribution of synonymous mutations to human disease

C. Kimchi-Sarfaty, Z. Sauna, 2011, Nature Reviews Genetics.

The molecular basis of the action of disulfiram as a modulator of the multidrug resistance-linked ATP binding cassette transporters MDR1 (ABCB1) and MRP1 (ABCC1).

Z. Sauna, S. Ambudkar, Xiang-Hong Peng, 2004, Molecular pharmacology.

Observations regarding the immunogenicity of BDD‐rFVIII derived from a mechanistic personalized medicine perspective

C. Yanover, Z. Sauna, A. Ameri, 2012, Journal of thrombosis and haemostasis : JTH.

P-glycoprotein: from genomics to mechanism

Chava Kimchi-Sarfaty, Zuben E Sauna, Michael M Gottesman, 2003, Oncogene.

Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima.

Ruth Nussinov, Chung-Jung Tsai, Chava Kimchi-Sarfaty, 2008, Journal of molecular biology.

Fc fusion as a platform technology: potential for modulating immunogenicity.

Zuben E Sauna, Basil Golding, Z. Sauna, 2015, Trends in biotechnology.

Fc-Fusion Drugs Have FcγR/C1q Binding and Signaling Properties That May Affect Their Immunogenicity

Z. Sauna, B. Golding, H. Hengel, 2019, The AAPS Journal.

Modulating immunogenicity of factor IX by fusion to an immunoglobulin Fc domain: a study using a hemophilia B mouse model

Z. Sauna, B. Golding, S. Strome, 2017, Journal of thrombosis and haemostasis : JTH.

Cyclosporin A Impairs the Secretion and Activity of ADAMTS13 (A Disintegrin and Metalloprotease with Thrombospondin Type 1 Repeat)*

A. Komar, R. Bram, C. Kimchi-Sarfaty, 2012, The Journal of Biological Chemistry.

Large scale analysis of the mutational landscape in HT-SELEX improves aptamer discovery

Phuong Dao, E. Gilboa, T. Przytycka, 2015, Nucleic acids research.

Translational and transcriptional responses in human primary hepatocytes under hypoxia.

C. Kimchi-Sarfaty, Z. Sauna, Jacob Kames, 2019, American journal of physiology. Gastrointestinal and liver physiology.

Mitigation of T-cell dependent immunogenicity by reengineering factor VIIa analogue.

Z. Sauna, J. Marcotrigiano, M. Fogg, 2019, Blood advances.

Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer.

Scott E. Martin, J. Weinstein, M. Gottesman, 2006, Cancer research.

Secondary failure: immune responses to approved protein therapeutics.

Z. Sauna, H. A. D. Lagassé, Quinn McCormick, 2021, Trends in molecular medicine.

Immunogenicity assessment during the development of protein therapeutics

Z. Sauna, A. Rosenberg, 2018, The Journal of pharmacy and pharmacology.

Effects of codon optimization on coagulation factor IX translation and structure: Implications for protein and gene therapies

Michael DiCuccio, A. Komar, N. Janjić, 2019, Scientific Reports.

Single synonymous mutation in factor IX alters protein properties and underlies haemophilia B

A. Komar, C. Kimchi-Sarfaty, Z. Sauna, 2016, Journal of Medical Genetics.

The sounds of silence: synonymous mutations affect function.

M. Gottesman, C. Kimchi-Sarfaty, Z. Sauna, 2007, Pharmacogenomics.

Importance of the conserved Walker B glutamate residues, 556 and 1201, for the completion of the catalytic cycle of ATP hydrolysis by human P-glycoprotein (ABCB1).

Z. Sauna, S. Ambudkar, Marianna Müller, 2002, Biochemistry.

Quantitative HLA‐class‐II/factor VIII (FVIII) peptidomic variation in dendritic cells correlates with the immunogenic potential of therapeutic FVIII proteins in hemophilia A

J. Blangero, J. Curran, M. Almeida, 2020, Journal of thrombosis and haemostasis : JTH.

Modified aptamers as reagents to characterize recombinant human erythropoietin products

N. Janjić, Z. Sauna, Wojciech Jankowski, 2020, Scientific Reports.

Peptides identified on monocyte-derived dendritic cells: a marker for clinical immunogenicity to FVIII products.

Z. Sauna, N. Key, V. Diego, 2019, Blood advances.

Endotoxin contamination in commercially available Cas9 proteins potentially induces T-cell mediated responses

Z. Sauna, V. Simhadri, Joseph R. McGill, 2021, Gene Therapy.

A structural homology approach to identify potential cross-reactive antibody responses following SARS-CoV-2 infection

Z. Sauna, B. Golding, Wojciech Jankowski, 2022, Scientific Reports.

Detection of intracellular ADAMTS13, a secreted zinc‐metalloprotease, via flow cytometry

S. Friedman, C. Kimchi-Sarfaty, Z. Sauna, 2009, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Post hoc assessment of the immunogenicity of bioengineered factor VIIa demonstrates the use of preclinical tools

G. S. Pandey, Søren B. Padkjær, K. Lamberth, 2017, Science Translational Medicine.

TCPro: an In Silico Risk Assessment Tool for Biotherapeutic Protein Immunogenicity

O. Yogurtçu, Z. Sauna, Hong Yang, 2019, The AAPS Journal.

Solvent interconnectedness permits measurement of proximal as well as distant phase transitions in polymer mixtures by fluorescence.

C. N. Madhavarao, Z. Sauna, V. sitaramam, 2001, Biophysical chemistry.

Structural, functional, and immunogenicity implications of F9 gene recoding

A. Komar, C. Kimchi-Sarfaty, Z. Sauna, 2022, Blood advances.

Evidence for the interaction of imatinib at the transport-substrate site(s) of the multidrug-resistance-linked ABC drug transporters ABCB1 (P-glycoprotein) and ABCG2

Z. Sauna, S. Ambudkar, S. Shukla, 2008, Leukemia.

The intron-22-inverted F8 locus permits factor VIII synthesis: explanation for low inhibitor risk and a role for pharmacogenomics.

C. Yanover, Z. Sauna, T. Nichols, 2015, Blood.

Factor VIII-Fc Activates Natural Killer Cells via Fc-Mediated Interactions With CD16

Z. Sauna, B. Golding, M. Jacquemin, 2021, Frontiers in Immunology.

Cas9-derived peptides presented by MHC Class II that elicit proliferation of CD4+ T-cells

Z. Sauna, V. Simhadri, Joseph R. McGill, 2021, Nature Communications.

What does a common channel for electrolytes and non-electrolytes in the sperm mean?

Z. Sauna, V. sitaramam, 2000, Journal of theoretical biology.

Plasma derivatives: new products and new approaches.

C. Kimchi-Sarfaty, Z. Sauna, B. Golding, 2012, Biologicals : journal of the International Association of Biological Standardization.

Building better drugs: developing and regulating engineered therapeutic proteins.

Chen Yanover, Chava Kimchi-Sarfaty, Tal Schiller, 2013, Trends in pharmacological sciences.

Genetic determinants of immunogenicity to factor IX during the treatment of haemophilia B

C. Yanover, C. Kimchi-Sarfaty, Z. Sauna, 2015, Haemophilia : the official journal of the World Federation of Hemophilia.

Small ncRNA Expression-Profiling of Blood from Hemophilia A Patients Identifies miR-1246 as a Potential Regulator of Factor 8 Gene

C. Kimchi-Sarfaty, Z. Sauna, C. Atreya, 2015, PloS one.

Endogenous factor VIII synthesis from the intron 22–inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A

C. Yanover, T. Przytycka, S. Cole, 2013, Nature Medicine.

Title Endogenous factor VIII synthesis from the intron 22-inverted F 8 locus may modulate the immunogenicity of replacement therapy for hemophilia

Yasmin, C. Yanover, T. Przytycka, 2014 .

Polymorphisms in the F8 Gene and MHC-II Variants as Risk Factors for the Development of Inhibitory Anti-Factor VIII Antibodies during the Treatment of Hemophilia A: A Computational Assessment

Chen Yanover, Zuben E. Sauna, Gouri Shankar Pandey, 2013, PLoS Comput. Biol..

Detection of Intracellular Factor VIII Protein in Peripheral Blood Mononuclear Cells by Flow Cytometry

Z. Sauna, S. Tseng, T. Howard, 2013, BioMed research international.

Evaluating and Mitigating the Immunogenicity of Therapeutic Proteins.

Zuben E Sauna, Basil Golding, Joao Pedras-Vasconcelos, 2018, Trends in biotechnology.

Summary report of the First International Conference on inhibitors in haemophilia A.

L. Mantovani, P. Mannucci, F. Rosendaal, 2017, Blood transfusion = Trasfusione del sangue.

Personalized approaches to the treatment of hemophilia A and B.

C. Kimchi-Sarfaty, Z. Sauna, Aditi Banerjee, 2015, Personalized medicine.

Recent advances in (therapeutic protein) drug development

Zuben E. Sauna, Chava Kimchi-Sarfaty, Aikaterini Alexaki, 2017, F1000Research.

Synthesis and preliminary analysis of a P-glycoprotein-specific [3H]-benzophenone photoaffinity label based on (-)-stipiamide.

Z. Sauna, S. Ambudkar, M. Andrus, 2000, Bioorganic & medicinal chemistry letters.

Efficient Propagation of Circulating Tumor Cells: A First Step for Probing Tumor Metastasis

Kelly P. Stanton, S. Agarwal, Z. Sauna, 2020, Cancers.

Genomics and the mechanism of P-glycoprotein (ABCB1)

Z. Sauna, S. Ambudkar, In-Wha Kim, 2007, Journal of bioenergetics and biomembranes.

Exposing synonymous mutations.

Chava Kimchi-Sarfaty, Zuben E Sauna, C. Kimchi-Sarfaty, 2014, Trends in genetics : TIG.

Prevalence of Pre-existing Antibodies to CRISPR-Associated Nuclease Cas9 in the USA Population

Haiyan Jiang, Zuben E. Sauna, Z. Sauna, 2018, Molecular therapy. Methods & clinical development.

The A‐loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding

Z. Sauna, S. Ambudkar, D. Xia, 2006, FEBS letters.

Further Evidence That MicroRNAs Can Play a Role in Hemophilia A Disease Manifestation: F8 Gene Downregulation by miR-19b-3p and miR-186-5p

J. Oldenburg, Z. Sauna, C. Atreya, 2020, Frontiers in Cell and Developmental Biology.

Silent (synonymous) SNPs: should we care about them?

Ryan Hunt, Chava Kimchi-Sarfaty, Zuben E Sauna, 2009, Methods in molecular biology.

HLA Variants and Inhibitor Development in Hemophilia A: A Retrospective Case-Controlled Study Using the ATHNdataset

Z. Sauna, V. Simhadri, Joseph R. McGill, 2021, Frontiers in Medicine.

Silent polymorphisms speak: how they affect pharmacogenomics and the treatment of cancer.

Chava Kimchi-Sarfaty, Zuben E Sauna, Michael M Gottesman, 2007, Cancer research.

Mathematical model of a personalized neoantigen cancer vaccine and the human immune system

O. Yogurtçu, Z. Sauna, Hong Yang, 2021, medRxiv.

Correlation between Steady-state ATP Hydrolysis and Vanadate-induced ADP Trapping in Human P-glycoprotein

Z. Sauna, S. Ambudkar, K. Kerr, 2001, The Journal of Biological Chemistry.

Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein.

Z. Sauna, S. Ambudkar, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Volume regulation of spermatozoa by quinine‐sensitive channels

Z. Sauna, V. sitaramam, V. Somlata, 1997, Molecular reproduction and development.

Inhibition of multidrug resistance-linked P-glycoprotein (ABCB1) function by 5'-fluorosulfonylbenzoyl 5'-adenosine: evidence for an ATP analogue that interacts with both drug-substrate-and nucleotide-binding sites.

S. Durell, E. Appella, L. Jenkins, 2011, Biochemistry.

About a switch: how P-glycoprotein (ABCB1) harnesses the energy of ATP binding and hydrolysis to do mechanical work

Z. Sauna, S. Ambudkar, 2007, Molecular Cancer Therapeutics.

The power of the pump: mechanisms of action of P-glycoprotein (ABCB1).

In-Wha Kim, Zuben E Sauna, Z. Sauna, 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

A novel way to spread drug resistance in tumor cells: functional intercellular transfer of P-glycoprotein (ABCB1).

M. Gottesman, G. Szakács, Z. Sauna, 2005, Trends in pharmacological sciences.

Disulfiram, an old drug with new potential therapeutic uses for human cancers and fungal infections.

Z. Sauna, S. Ambudkar, S. Shukla, 2005, Molecular bioSystems.

Multidrug Resistance Protein 4 (ABCC4)-mediated ATP Hydrolysis

Z. Sauna, S. Ambudkar, K. Nandigama, 2004, Journal of Biological Chemistry.

Synonymous Mutations as a Cause of Human Genetic Disease

C. Kimchi-Sarfaty, Z. Sauna, 2013 .

Higher-Order Structure and Protein Aggregate Characterization of Protein Therapeutics: Perspectives from Good Manufacturing Practices and Regulatory Guidance

C. Kimchi-Sarfaty, Z. Sauna, J. Cipollo, 2013 .

Identification of sequence-structure RNA binding motifs for SELEX-derived aptamers

Teresa M. Przytycka, Elena Zotenko, Adam Friedman, 2012, Bioinform..

Evidence for the Vectorial Nature of Drug (Substrate)-stimulated ATP Hydrolysis by Human P-glycoprotein* 210

Z. Sauna, S. Ambudkar, M. Müller, 2001, The Journal of Biological Chemistry.

Synthesis and analysis of polyethylene glycol linked P-glycoprotein-specific homodimers based on (−)-stipiamide

Z. Sauna, S. Ambudkar, M. Andrus, 2001 .

Characterization of the Catalytic Cycle of ATP Hydrolysis by Human P-glycoprotein

Z. Sauna, S. Ambudkar, 2001, The Journal of Biological Chemistry.

The Mechanism of Action of Multidrug-Resistance-Linked P-Glycoprotein

Z. Sauna, S. Ambudkar, K. Kerr, 2001, Journal of bioenergetics and biomembranes.

Elf1p, a Member of the ABC Class of ATPases, Functions as a mRNA Export Factor in Schizosacchromyces pombe *

J. Yoon, Z. Sauna, S. Ambudkar, 2002, The Journal of Biological Chemistry.

Nonequivalence of the Nucleotide Binding Domains of the ArsA ATPase*

Z. Sauna, S. Ambudkar, Yong Jiang, 2005, Journal of Biological Chemistry.

A Foundational Study for Normal F8-Containing Mouse Models for the miRNA Regulation of Hemophilia A: Identification and Analysis of Mouse miRNAs that Downregulate the Murine F8 Gene

Z. Sauna, C. Atreya, Katarzyna I. Jankowska, 2020, International journal of molecular sciences.

Role of microRNAs in Hemophilia and Thrombosis in Humans

Z. Sauna, C. Atreya, Katarzyna I. Jankowska, 2020, International journal of molecular sciences.

Pharmacogenetics and the immunogenicity of protein therapeutics

C. Yanover, Z. Sauna, G. Pierce, 2011, Nature Biotechnology.

Integrative RNA Biology Special Interest Group Meeting

E. Gilboa, T. Przytycka, Z. Sauna, 2015 .

Pharmacokinetics of antibodies during pregnancy: General pharmacokinetics and pregnancy related physiological changes (Part 1).

Z. Sauna, I. Mahmood, M. Tegenge, 2023, International immunopharmacology.

Analysis of F9 point mutations and their correlation to severity of haemophilia B disease

T. Przytycka, A. Komar, C. Kimchi-Sarfaty, 2012, Haemophilia.

Characterization of Conformation-Sensitive Antibodies to ADAMTS13, the von Willebrand Cleavage Protease

Robert L. Fathke, C. Kimchi-Sarfaty, Z. Sauna, 2009, PloS one.

Protein Therapeutics

Sudheer Kumar Singh, A. Komar, C. Kimchi-Sarfaty, 2017 .

Osmotic perturbations induce differential movements in the core and periphery of proteins, membranes and micelles.

C. N. Madhavarao, Z. Sauna, V. sitaramam, 2001, Biophysical chemistry.

Mutational analysis of ABCG2: role of the GXXXG motif.

Michael Dean, Zuben E Sauna, S. Bates, 2004, Biochemistry.

Disulfiram is a potent modulator of multidrug transporter Cdr1p of Candida albicans.

Suneet Shukla, Zuben E Sauna, Rajendra Prasad, 2004, Biochemical and biophysical research communications.

Exploiting Reaction Intermediates of the ATPase Reaction to Elucidate the Mechanism of Transport by P-glycoprotein (ABCB1)*

Z. Sauna, S. Ambudkar, K. Nandigama, 2006, Journal of Biological Chemistry.

Fc-Fusion Drugs Have FcγR/C1q Binding and Signaling Properties That May Affect Their Immunogenicity

Z. Sauna, B. Golding, H. Hengel, 2019, The AAPS Journal.

Large solutes induce structural perturbations in proteins and membranes.

C. N. Madhavarao, Z. Sauna, V. sitaramam, 2001, International journal of biological macromolecules.

The Synonymous V107V Mutation In Factor IX Is Not So Silent and May Cause Hemophilia B In Patients

A. Komar, C. Kimchi-Sarfaty, Z. Sauna, 2010 .

Catalytic cycle of ATP hydrolysis by P-glycoprotein: evidence for formation of the E.S reaction intermediate with ATP-gamma-S, a nonhydrolyzable analogue of ATP.

Stephan Kopp, In-Wha Kim, Peter Chiba, 2007, Biochemistry.

Rate-limiting step in electron transport. Osmotically sensitive diffusion of quinones through voids in the bilayer.

Z. Sauna, J. Mathai, V Sitaramam, 1993, The Journal of biological chemistry.

The signaling interface of the yeast multidrug transporter Pdr5 adopts a cis conformation, and there are functional overlap and equivalence of the deviant and canonical Q-loop residues.

Z. Sauna, S. Ambudkar, D. Xia, 2010, Biochemistry.

The conserved tyrosine residues 401 and 1044 in ATP sites of human P-glycoprotein are critical for ATP binding and hydrolysis: evidence for a conserved subdomain, the A-loop in the ATP-binding cassette.

Zuben E Sauna, Z. Sauna, S. Ambudkar, 2006, Biochemistry.

Dose optimization of an adjuvanted peptide-based personalized neoantigen melanoma vaccine

O. Yogurtçu, Z. Sauna, Hong Yang, 2023, bioRxiv.

Biochemical basis of polyvalency as a strategy for enhancing the efficacy of P-glycoprotein (ABCB1) modulators: stipiamide homodimers separated with defined-length spacers reverse drug efflux with greater efficacy.

Z. Sauna, S. Ambudkar, M. Andrus, 2004, Biochemistry.

Clinical manifestation of hemophilia A in the absence of mutations in the F8 gene that encodes FVIII: role of microRNAs

J. Oldenburg, Z. Sauna, C. Atreya, 2019, Transfusion.

Pharmacokinetics of antibodies during Pregnancy: Impact of pregnancy on the pharmacokinetics of antibodies (Part 2).

Z. Sauna, I. Mahmood, M. Tegenge, 2023, International immunopharmacology.

TCPro: an In Silico Risk Assessment Tool for Biotherapeutic Protein Immunogenicity

O. Yogurtçu, Z. Sauna, Hong Yang, 2019, The AAPS Journal.

A Retrospective Review of Center for Biologics Evaluation and Research Advisory Committee Meetings in the Context of the FDA’s Benefit-Risk Framework

O. Yogurtçu, Z. Sauna, R. Forshee, 2023, The AAPS Journal.

The synthesis and evaluation of a solution phase indexed combinatorial library of non-natural polyenes for reversal of P-glycoprotein mediated multidrug resistance.

Z. Sauna, S. Ambudkar, M. Andrus, 2000, The Journal of organic chemistry.

Mutations Define Cross-talk between the N-terminal Nucleotide-binding Domain and Transmembrane Helix-2 of the Yeast Multidrug Transporter Pdr5

Z. Sauna, S. Ambudkar, S. Cronin, 2008, Journal of Biological Chemistry.

SampPick: Selection of a Cohort of Subjects Matching a Population HLA Distribution

O. Yogurtçu, Z. Sauna, Hong Yang, 2019, Front. Immunol..

Characterization of Coding Synonymous and Non-Synonymous Variants in ADAMTS13 Using Ex Vivo and In Silico Approaches

Robert L. Fathke, Y. Mandel-Gutfreund, T. Przytycka, 2012, PloS one.

AptaCluster - A Method to Cluster HT-SELEX Aptamer Pools and Lessons from Its Application

Teresa M. Przytycka, Jan Hoinka, Eli Gilboa, 2014, RECOMB.

Pharmacogenetics and the Immunogenicity of Protein Therapeutics.

Z. Sauna, G. Pandey, 2014, Journal of Interferon and Cytokine Research.

Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima.

R. Nussinov, Chung-Jung Tsai, M. Gottesman, 2008, Journal of molecular biology.

Analysis of F9 point mutations and their correlation to severity of haemophilia B disease

T. Przytycka, C. Kimchi-Sarfaty, Z. Sauna, 2012, Haemophilia.

Supporting Online Material

Lippincott-Schwartz, S. Edelman, E. Ruppin, 2004 .

Synthesis of FVIII in Hemophilia-A patients with the intron-22-inversion may modulate immunogenicity

C. Yanover, T. Przytycka, J. Curran, 2013, Nature Medicine.

Cyclosporin A Impairs the Secretion and Activity of ADAMTS13 (A Disintegrin and Metalloprotease with Thrombospondin Type 1 Repeat)*

A. Komar, R. Bram, C. Kimchi-Sarfaty, 2012, The Journal of Biological Chemistry.

Emerging approaches to induce immune tolerance to therapeutic proteins.

Z. Sauna, Daniel Lagassé, Justine C. Noel, 2023, Trends in pharmacological sciences.

Multidrug Resistance Protein 4 (ABCC4)-mediated ATP Hydrolysis EFFECT OF TRANSPORT SUBSTRATES AND CHARACTERIZATION OF THE POST-HYDROLYSIS TRANSITION STATE*

Z. Sauna, S. Ambudkar, K. Nandigama, 2004 .

Engineering and evaluation of FXa bypassing agents that restore hemostasis following Apixaban associated bleeding

Z. Sauna, S. Surov, Nancy E. Hernandez, 2024, Nature communications.

Complete inhibition of the Pdr5p multidrug efflux pump ATPase activity by its transport substrate clotrimazole suggests that GTP as well as ATP may be used as an energy source.

Z. Sauna, S. Ambudkar, Z. Kon, 2007, Biochemistry.

Single‐nucleotide variations defining previously unreported ADAMTS13 haplotypes are associated with differential expression and activity of the VWF‐cleaving protease in a Salvadoran congenital thrombotic thrombocytopenic purpura family

V. Marder, C. Kimchi-Sarfaty, Z. Sauna, 2014, British journal of haematology.