S. Ambudkar

S. Ambudkar, Zhe-Sheng Chen, S. Ohnuma, 2013, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

The molecular basis of the action of disulfiram as a modulator of the multidrug resistance-linked ATP binding cassette transporters MDR1 (ABCB1) and MRP1 (ABCC1).

Z. Sauna, S. Ambudkar, Xiang-Hong Peng, 2004, Molecular pharmacology.

HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

I. Pastan, M. Gottesman, K. Jeang, 1998, Biochemistry.

Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors.

Xin Hu, Suneet Shukla, Damien Y. Duveau, 2013, Bioorganic & medicinal chemistry letters.

ABC Transporter Modulatory Drugs from Marine Sources: A New Approach to Overcome Drug Resistance in Cancer

S. Ambudkar, Zhe-Sheng Chen, Deshen Wang, 2015 .

Bioluminescent imaging of drug efflux at the blood–brain barrier mediated by the transporter ABCG2

Bih-Rong Wei, R. M. Simpson, M. Gottesman, 2013, Proceedings of the National Academy of Sciences.

P-glycoprotein: from genomics to mechanism

Chava Kimchi-Sarfaty, Zuben E Sauna, Michael M Gottesman, 2003, Oncogene.

Studies with Novel Pdr5p Substrates Demonstrate a Strong Size Dependence for Xenobiotic Efflux*

M. Gottesman, S. Ambudkar, J. Golin, 2003, The Journal of Biological Chemistry.

Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima.

Ruth Nussinov, Chung-Jung Tsai, Chava Kimchi-Sarfaty, 2008, Journal of molecular biology.

VAMP2-dependent exocytosis regulates plasma membrane insertion of TRPC3 channels and contributes to agonist-stimulated Ca2+ influx.

S. Ambudkar, Brij B. Singh, M. Knepper, 2004, Molecular cell.

Human-Mouse Chimeras with Normal Expression and Function Reveal That Major Domain Swapping Is Tolerated by P-Glycoprotein (ABCB1).

M. Gottesman, M. Hall, S. Ambudkar, 2016, Biochemistry.

UhpT, the sugar phosphate antiporter of Escherichia coli, functions as a monomer.

P. Maloney, S. Ambudkar, V. Anantharam, 1990, The Journal of biological chemistry.

The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations

S. Ambudkar, S. Shukla, M. Baer, 2015, Investigational New Drugs.

The FLT3 Inhibitor Quizartinib Inhibits ABCG2 at Pharmacologically Relevant Concentrations, with Implications for Both Chemosensitization and Adverse Drug Interactions

S. Ambudkar, S. Shukla, M. Baer, 2013, PloS one.

Preclinical Development The Novel BCR-ABL and FLT 3 Inhibitor Ponatinib Is a Potent Inhibitor of the MDR-Associated ATP-Binding Cassette Transporter ABCG 2

Hong-Bin Fang, S. Ambudkar, Zhe-Sheng Chen, 2012 .

The Novel BCR-ABL and FLT3 Inhibitor Ponatinib Is a Potent Inhibitor of the MDR-Associated ATP-Binding Cassette Transporter ABCG2

Hong-Bin Fang, S. Ambudkar, Zhe-Sheng Chen, 2012, Molecular Cancer Therapeutics.

Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells

Robert W. Robey, Suneet Shukla, S. Bates, 2009, Cancer Chemotherapy and Pharmacology.

Overexpression of ATP-Binding Cassette Subfamily G Member 2 Confers Resistance to Phosphatidylinositol 3-Kinase Inhibitor PF-4989216 in Cancer Cells.

T. Hung, S. Ambudkar, Chung-Pu Wu, 2017, Molecular pharmaceutics.

Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder.

S. Ambudkar, P. Limtrakul, K. Nandigama, 2004, Biochemical pharmacology.

Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells

Y. Wang, S. Bates, R. Robey, 2007, Leukemia.

Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer.

Scott E. Martin, J. Weinstein, M. Gottesman, 2006, Cancer research.

South Asian Medicinal Compounds as Modulators of Resistance to Chemotherapy and Radiotherapy

S. Ambudkar, N. Prasad, Ganesan Muthusamy, 2016, Cancers.

Sitravatinib, a Tyrosine Kinase Inhibitor, Inhibits the Transport Function of ABCG2 and Restores Sensitivity to Chemotherapy-Resistant Cancer Cells in vitro

S. Ambudkar, Zhe-Sheng Chen, Zhuoxun Wu, 2020, Frontiers in Oncology.

ABC drug transporters as molecular targets for the prevention of multidrug resistance and drug-drug interactions.

A. Calcagno, S. Ambudkar, S. Shukla, 2007, Current drug delivery.

Selective reversal of BCRP‐mediated MDR by VEGFR‐2 inhibitor ZM323881

Lili Liu, S. Ambudkar, Zhe-Sheng Chen, 2017, Biochemical pharmacology.

The sounds of silence: synonymous mutations affect function.

M. Gottesman, C. Kimchi-Sarfaty, Z. Sauna, 2007, Pharmacogenomics.

Synthesis and Characterization of Bodipy-FL-Cyclosporine A as a Substrate for Multidrug Resistance-Linked P-Glycoprotein (ABCB1)

S. Ambudkar, Andaleeb Sajid, N. Raju, 2019, Drug Metabolism and Disposition.

Importance of the conserved Walker B glutamate residues, 556 and 1201, for the completion of the catalytic cycle of ATP hydrolysis by human P-glycoprotein (ABCB1).

Z. Sauna, S. Ambudkar, Marianna Müller, 2002, Biochemistry.

Differential effects of the immunosuppressive agents cyclosporin A, tacrolimus and sirolimus on drug transport by multidrug resistance proteins

S. Ambudkar, S. Shukla, H. Minderman, 2007, Cancer Chemotherapy and Pharmacology.

Screening dietary flavonoids for the reversal of P-glycoprotein-mediated multidrug resistance in cancer.

D. Velmurugan, S. Ambudkar, N. Prasad, 2016, Molecular bioSystems.

Mechanistic Insights into Photodynamic Regulation of Adenosine 5′-Triphosphate-Binding Cassette Drug Transporters

S. Ambudkar, Huang‐Chiao Huang, Barry J. Liang, 2021, ACS Pharmacology & Translational Science.

Elucidation of the structural basis of interaction of the BCR-ABL kinase inhibitor, nilotinib (Tasigna®) with the human ABC drug transporter P-glycoprotein

Damien Y. Duveau, M. Boxer, S. Ambudkar, 2014, Leukemia.

Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter

Olivia W. Lee, M. Gottesman, M. Hall, 2021, Scientific reports.

Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter

Olivia W. Lee, M. Gottesman, M. Hall, 2021, Scientific Reports.

Human Immunodeficiency Virus Protease Inhibitors Interact with ATP Binding Cassette Transporter 4/Multidrug Resistance Protein 4: A Basis for Unanticipated Enhanced Cytotoxicity

S. Ekins, J. Schuetz, S. Ambudkar, 2013, Molecular Pharmacology.

Human Immunodeficiency Virus Protease Inhibitors Interact with ATP Binding Cassette Transporter 4 / Multidrug Resistance Protein 4 : A Basis for Unanticipated Enhanced Cytotoxicity s

S. Ekins, J. Schuetz, S. Ambudkar, 2013 .

Ceramide Glycosylation by Glucosylceramide Synthase Selectively Maintains the Properties of Breast Cancer Stem Cells*

K. Khoo, R. Shi, X. Gu, 2012, The Journal of Biological Chemistry.

P-glycoprotein Mediates Resistance to the Anaplastic Lymphoma Kinase Inhiitor Ensartinib in Cancer Cells

T. Hung, S. Ambudkar, Jau-Song Yu, 2022, Cancers.

Overexpression of ABCB1 and ABCG2 contributes to reduced efficacy of the PI3K/mTOR inhibitor samotolisib (LY3023414) in cancer cell lines.

T. Hung, S. Ambudkar, Jau-Song Yu, 2020, Biochemical pharmacology.

The positive inotropic agent DPI-201106 selectively reverses ABCB1-mediated multidrug resistance in cancer cell lines.

T. Hung, S. Ambudkar, Chung-Pu Wu, 2018, Cancer letters.

Clinical relevance of multidrug resistance gene expression in ovarian serous carcinoma effusions.

M. Gottesman, S. Varma, Junbai Wang, 2011, Molecular pharmaceutics.

The glucose‐6‐phosphate transporter is a phosphate‐linked antiporter deficient in glycogen storage disease type Ib and Ic

S. Ambudkar, J. Chou, K. Nandigama, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Characterization of phosphate:hexose 6-phosphate antiport in membrane vesicles of Streptococcus lactis.

P. Maloney, S. Ambudkar, 1984, The Journal of biological chemistry.

PBK/TOPK inhibitor OTS964 resistance is mediated by ABCB1-dependent transport function in cancer: in vitro and in vivo study

S. Ambudkar, Zhuoxun Wu, Jing-Quan Wang, 2022, Molecular cancer.

The FLT3 inhibitor midostaurin selectively resensitizes ABCB1-overexpressing multidrug-resistant cancer cells to conventional chemotherapeutic agents.

S. Ambudkar, S. Hsu, Chung-Pu Wu, 2019, Cancer letters.

Therapeutics , Targets , and Chemical Biology MDR 1 Synonymous Polymorphisms Alter Transporter Speci fi city and Protein Stability in a Stable Epithelial Monolayer

M. Gottesman, C. Kimchi-Sarfaty, S. Ambudkar, 2014 .

MDR1 synonymous polymorphisms alter transporter specificity and protein stability in a stable epithelial monolayer.

M. Gottesman, C. Kimchi-Sarfaty, S. Ambudkar, 2014, Cancer research.

ABCB1 limits the cytotoxic activity of TAK-243, an inhibitor of the ubiquitin-activating enzyme UBA1.

S. Ambudkar, Zhuoxun Wu, Jing-Quan Wang, 2022, Frontiers in bioscience.

Novel Potent ABCB1 Modulator, Phenethylisoquinoline Alkaloid, Reverses Multidrug Resistance in Cancer Cell.

M. Ishida, M. Unno, S. Ambudkar, 2018, Molecular pharmaceutics.

ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) are not primary resistance factors for cabazitaxel

S. Ambudkar, Zhe-Sheng Chen, S. Shukla, 2015, Chinese journal of cancer.

BBA, a derivative of 23-hydroxybetulinic acid, potently reverses ABCB1-mediated drug resistance in vitro and in vivo.

S. Ambudkar, J. Bhatnagar, Zhe-Sheng Chen, 2012, Molecular pharmaceutics.

OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance.

S. Ambudkar, Zhe-Sheng Chen, L. Fu, 2012, Biochemical pharmacology.

Cancer esearch apeutics , Targets , and Chemical Biology tinib ( YN 968 D 1 ) Reverses Multidrug Resistance by biting the Efflux Function of Multiple ATP-Binding R sette Transporters

S. Ambudkar, Zhe-Sheng Chen, A. Tiwari, 2010 .

Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters.

Fang Wang, S. Ambudkar, Zhe-Sheng Chen, 2010, Cancer research.

tinib (YN968D1) Reverses Multidrug Resistance by biting the Efflux Function of Multiple ATP-Binding

Fan Wang, S. Ambudkar, Zhe-Sheng Chen, 2010 .

Cassette Transporters Inhibiting the Efflux Function of Multiple ATP-Binding Apatinib ( YN 968 D 1 ) Reverses Multidrug Resistance

S. Ambudkar, A. Tiwari, Yong‐ju Liang, 2010 .

Reversal of ABC drug transporter-mediated multidrug resistance in cancer cells: evaluation of current strategies.

A. Calcagno, S. Ambudkar, Chung-Pu Wu, 2008, Current molecular pharmacology.

The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors

Bhargav A. Patel, S. Ambudkar, Zhe-Sheng Chen, 2017, Molecular Cancer Therapeutics.

Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity.

S. Ambudkar, S. Ohnuma, G. Godlewski, 2010, The Journal of clinical investigation.

Interindividual Variability in Hepatic Organic Anion-Transporting Polypeptides and P-Glycoprotein (ABCB1) Protein Expression: Quantification by Liquid Chromatography Tandem Mass Spectroscopy and Influence of Genotype, Age, and Sex

R. Evers, S. Ambudkar, S. Shukla, 2014, Drug Metabolism and Disposition.

Icotinib antagonizes ABCG2-mediated multidrug resistance, but not the pemetrexed resistance mediated by thymidylate synthase and ABCG2

S. Bates, R. Robey, S. Ambudkar, 2014, Oncotarget.

Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478.

S. Bates, R. Robey, S. Ambudkar, 2009, Biochemical pharmacology.

Inhibition of ABCG2-mediated transport by protein kinase inhibitors with a bisindolylmaleimide or indolocarbazole structure

S. Bates, R. Robey, S. Ambudkar, 2007, Molecular Cancer Therapeutics.

Expression of the multidrug transporter P-glycoprotein is inversely related to that of apoptosis-associated endogenous TRAIL.

M. Gottesman, S. Ambudkar, J. Gillet, 2015, Experimental cell research.

Overexpression of Human ABCB1 and ABCG2 Reduces the Susceptibility of Cancer Cells to the Histone Deacetylase 6-Specific Inhibitor Citarinostat

T. Hung, S. Ambudkar, Jau-Song Yu, 2021, International journal of molecular sciences.

A Phenylfurocoumarin Derivative Reverses ABCG2-Mediated Multidrug Resistance In Vitro and In Vivo

M. Unno, S. Ambudkar, K. Ohsawa, 2021, International Journal of Molecular Sciences.

Tivozanib reverses multidrug resistance mediated by ABCB1 (P-glycoprotein) and ABCG2 (BCRP).

S. Ambudkar, Zhe-Sheng Chen, Atish Patel, 2014, Future oncology.

Use of Baculovirus BacMam Vectors for Expression of ABC Drug Transporters in Mammalian Cells

S. Ambudkar, S. Shukla, K. Kapoor, 2012, Drug Metabolism and Disposition.

Microsoft Word-12042809-file00

R. Robey, S. Ambudkar, S. Shukla, 2010 .

Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2 (Cancer Research (2008) 68, (7905-7914))

Liwu Fu, R. Robey, S. Ambudkar, 2008 .

Evidence for the interaction of imatinib at the transport-substrate site(s) of the multidrug-resistance-linked ABC drug transporters ABCB1 (P-glycoprotein) and ABCG2

Z. Sauna, S. Ambudkar, S. Shukla, 2008, Leukemia.

SIS3, a specific inhibitor of Smad3 reverses ABCB1- and ABCG2-mediated multidrug resistance in cancer cell lines.

T. Hung, S. Ambudkar, Chung-Pu Wu, 2018, Cancer letters.

Synthetic Analogs of Curcumin Modulate the Function of Multidrug Resistance–Linked ATP-Binding Cassette Transporter ABCG2

H. Shibata, M. Ishida, M. Unno, 2017, Drug Metabolism and Disposition.

Mechanistic Insights into Photodynamic Regulation of Adenosine 5′-Triphosphate-Binding Cassette Drug Transporters

S. Ambudkar, Huang‐Chiao Huang, Barry J. Liang, 2021, ACS pharmacology & translational science.

An A666G mutation in transmembrane helix 5 of the yeast multidrug transporter Pdr5 increases drug efflux by enhancing cooperativity between transport sites

S. Ambudkar, L. Schmitt, J. Golin, 2019, Molecular microbiology.

Evidence for the critical role of transmembrane helices 1 and 7 in substrate transport by human P-glycoprotein (ABCB1)

S. Ambudkar, Andaleeb Sajid, Sabrina Lusvarghi, 2018, PloS one.

A-803467, a tetrodotoxin-resistant sodium channel blocker, modulates ABCG2-mediated MDR in vitro and in vivo

S. Ambudkar, Zhe-Sheng Chen, S. Shukla, 2015, Oncotarget.

Revealing the fate of cell surface human P-glycoprotein (ABCB1): The lysosomal degradation pathway.

S. Ambudkar, S. Ohnuma, W. Swaim, 2015, Biochimica et biophysica acta.

Design and Synthesis of Human ABCB1 (P-Glycoprotein) Inhibitors by Peptide Coupling of Diverse Chemical Scaffolds on Carboxyl and Amino Termini of (S)-Valine-Derived Thiazole Amino Acid

Bhargav A. Patel, S. Ambudkar, Zhe-Sheng Chen, 2014, Journal of medicinal chemistry.

Curcumin Modulates Efflux Mediated by Yeast ABC Multidrug Transporters and Is Synergistic with Antifungals

S. Ambudkar, S. Shukla, R. Prasad, 2009, Antimicrobial Agents and Chemotherapy.

Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin

S. Ambudkar, S. Shukla, P. Limtrakul, 2007, Molecular and Cellular Biochemistry.

Curcuminoids purified from turmeric powder modulate the function of human multidrug resistance protein 1 (ABCC1)

S. Ambudkar, T. Lee, P. Limtrakul, 2006, Cancer Chemotherapy and Pharmacology.

Crystal structure of the antigen-binding fragment of a monoclonal antibody specific for the multidrug-resistance-linked ABC transporter human P-glycoprotein.

L. Esser, S. Ambudkar, S. Shukla, 2016, Acta crystallographica. Section F, Structural biology communications.

Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoprotein.

I. Pastan, M. Gottesman, S. Ambudkar, 1998, Biochemistry.

Marine sponge-derived sipholane triterpenoids reverse P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells.

Liwu Fu, S. Ambudkar, Zhe-Sheng Chen, 2010, Biochemical pharmacology.

Human ABCB1 (P-glycoprotein) and ABCG2 mediate resistance to BI 2536, a potent and selective inhibitor of Polo-like kinase 1.

S. Ambudkar, Chung-Pu Wu, Sung-Han Hsiao, 2013, Biochemical pharmacology.

Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells.

S. Ambudkar, P. Limtrakul, S. Anuchapreeda, 2002, Biochemical pharmacology.

Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state.

I. Pastan, M. Gottesman, M. Ramachandra, 1998, Biochemistry.

Hydrogel-assisted functional reconstitution of human P-glycoprotein (ABCB1) in giant liposomes.

D. Sept, S. Ambudkar, S. Shukla, 2015, Biochimica et biophysica acta.

Kuguacin J isolated from Momordica charantia leaves inhibits P-glycoprotein (ABCB1)-mediated multidrug resistance.

Pornsiri Pitchakarn, S. Ambudkar, S. Ohnuma, 2012, The Journal of nutritional biochemistry.

Biochemical mechanism of modulation of human P-glycoprotein by stemofoline.

S. Ambudkar, S. Ohnuma, P. Limtrakul, 2011, Planta medica.

Sipholenol A, a marine‐derived sipholane triterpene, potently reverses P‐glycoprotein (ABCB1)‐mediated multidrug resistance in cancer cells

S. Ambudkar, Zhe-Sheng Chen, L. Fu, 2007, Cancer science.

Reconstitution of sugar phosphate transport systems of Escherichia coli.

P. Maloney, S. Ambudkar, T. Larson, 1986, The Journal of biological chemistry.

Ion Extrusion Systems in Bacteria

S. Ambudkar, H. Mobley, C. Chen, 1985, Annals of the New York Academy of Sciences.

Emerging nanotechnology-based therapeutics to combat multidrug-resistant cancer

S. Ambudkar, N. Rajendra Prasad, P. Yadav, 2022, Journal of Nanobiotechnology.

Saracatinib (AZD0530) is a potent modulator of ABCB1‐mediated multidrug resistance in vitro and in vivo

S. Ambudkar, Zhe-Sheng Chen, L. Fu, 2013, International journal of cancer.

NCX1 Surface Expression

H. Rahamimoff, C. Kimchi-Sarfaty, S. Ambudkar, 2002 .

Transport Activity and Surface Expression of the Na+-Ca2+ Exchanger NCX1 Are Inhibited by the Immunosuppressive Agent Cyclosporin A and by the Nonimmunosuppressive Agent PSC833*

H. Rahamimoff, C. Kimchi-Sarfaty, S. Ambudkar, 2002, The Journal of Biological Chemistry.

Evidence for the role of glycosylation in accessibility of the extracellular domains of human MRP1 (ABCC1).

S. Ambudkar, B. Petre, Xiang-Hong Peng, 2002, Biochemistry.

The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature.

Andrew Lee, S. Ambudkar, Luowei Li, 2010, Cancer research.

Linsitinib (OSI-906) antagonizes ATP-binding cassette subfamily G member 2 and subfamily C member 10-mediated drug resistance.

S. Bates, R. Robey, S. Ambudkar, 2014, The international journal of biochemistry & cell biology.

Reconstitution of ATP-dependent calcium transport from streptococci.

P. Maloney, S. Ambudkar, A. R. Lynn, 1986, The Journal of biological chemistry.

The role of hydrogen bond acceptor groups in the interaction of substrates with Pdr5p, a major yeast drug transporter.

P. Mehl, S. Ambudkar, P. Tuma, 2005, Biochemistry.

Hydroxygenkwanin Improves the Efficacy of Cytotoxic Drugs in ABCG2-Overexpressing Multidrug-Resistant Cancer Cells

T. Hung, S. Ambudkar, Chung-Pu Wu, 2022, International journal of molecular sciences.

Phosphate/hexose 6-phosphate antiport in Streptococcus lactis

P. Maloney, S. Ambudkar, J. Thomas, 1984, Journal of bacteriology.

CHAPTER 9 – Ion-Exchange Systems in Prokaryotes

S. Ambudkar, 1990 .

Prolonged drug selection of breast cancer cells and enrichment of cancer stem cell characteristics.

C. D. Salcido, M. Gottesman, J. Fostel, 2010, Journal of the National Cancer Institute.

Synthesis and preliminary analysis of a P-glycoprotein-specific [3H]-benzophenone photoaffinity label based on (-)-stipiamide.

Z. Sauna, S. Ambudkar, M. Andrus, 2000, Bioorganic & medicinal chemistry letters.

P-glycoprotein and multidrug resistance.

I. Pastan, M. Gottesman, S. Ambudkar, 1996, Current opinion in genetics & development.

Development of inhibitors of ATP-binding cassette drug transporters – present status and challenges

S. Ambudkar, S. Shukla, Chung-Pu Wu, 2008, Expert opinion on drug metabolism & toxicology.

Design, Synthesis, and Biological Evaluation of (S)‐Valine Thiazole‐Derived Cyclic and Noncyclic Peptidomimetic Oligomers as Modulators of Human P‐Glycoprotein (ABCB1)

Bhargav A. Patel, S. Ambudkar, T. Talele, 2014, Chembiochem : a European journal of chemical biology.

Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2.

R. Robey, S. Ambudkar, Zhe-Sheng Chen, 2008, Cancer research.

Anion-exchange mechanisms in bacteria

P. Maloney, S. Ambudkar, L. A. Sonna, 1990 .

Anion-exchange mechanisms in bacteria.

P. Maloney, S. Ambudkar, L. A. Sonna, 1990, Microbiological reviews.

Interaction of a Homologous Series of Amphiphiles with P-glycoprotein in a Membrane Environment—Contributions of Polar and Non-Polar Interactions

Luís M. S. Loura, S. Ambudkar, M. J. Moreno, 2023, Pharmaceutics.

Purification and reconstitution of human P-glycoprotein.

S. Ambudkar, I. Lelong, C. Cardarelli, 1998, Methods in enzymology.

Drug-stimulatable ATPase activity in crude membranes of human MDR1-transfected mammalian cells.

S. Ambudkar, 1998, Methods in enzymology.

Purification and reconstitution of functional human P-glycoprotein

S. Ambudkar, 1995, Journal of bioenergetics and biomembranes.

Reconstitution of a bacterial periplasmic permease in proteoliposomes and demonstration of ATP hydrolysis concomitant with transport.

G. Ames, P. Maloney, S. Ambudkar, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Genomics and the mechanism of P-glycoprotein (ABCB1)

Z. Sauna, S. Ambudkar, In-Wha Kim, 2007, Journal of bioenergetics and biomembranes.

Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance.

S. Bates, R. Robey, S. Ambudkar, 2007, Cancer research.

Functional Characterization of Candida albicans ABC Transporter Cdr1p

Smriti, S. Ambudkar, S. Shukla, 2003, Eukaryotic Cell.

Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein.

P. Agre, S. Ambudkar, M. Zeidel, 1992, Biochemistry.

The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance–linked ATP binding cassette drug transporter ABCG2

Suneet Shukla, S. Ambudkar, S. Shukla, 2007, Molecular Cancer Therapeutics.

In vitro and in vivo modulation of ABCG2 by functionalized aurones and structurally related analogs.

S. Ambudkar, Chung-Pu Wu, Hong-May Sim, 2011, Biochemical pharmacology.

ABC Transporter-Mediated Multidrug-Resistant Cancer.

S. Ambudkar, S. Shukla, A. Tiwari, 2019, Advances in experimental medicine and biology.

A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy

S. Thorgeirsson, M. Gottesman, S. Varma, 2016, Molecular Pharmacology.

Abstract 407: OTS964, a TOPK inhibitor, is susceptible to ABCG2-mediated drug resistance

S. Ambudkar, Zhe-Sheng Chen, Zhuoxun Wu, 2022, Cancer Research.

OTS964, a TOPK Inhibitor, Is Susceptible to ABCG2-Mediated Drug Resistance

S. Ambudkar, Zhe-Sheng Chen, Dong-Hua Yang, 2021, Frontiers in Pharmacology.

On the repression of the biogenesis of respiratory enzymes inSaccharomyces cereuisiae andEscherichia coli by glucose

K. Chandrasekaran, S. Ambudkar, T. Somasundaram, 1978, Proceedings / Indian Academy of Sciences.

Interactions of mefloquine with ABC proteins, MRP1 (ABCC1) and MRP4 (ABCC4) that are present in human red cell membranes.

S. Hladky, M. Barrand, S. Ambudkar, 2005, Biochemical pharmacology.

Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)).

T. Fojo, S. Bates, R. Robey, 2008, Biochemical pharmacology.

Neratinib Reverses ATP-Binding Cassette B1-Mediated Chemotherapeutic Drug Resistance In Vitro, In Vivo, and Ex Vivo

S. Ambudkar, Zhe-Sheng Chen, L. Fu, 2012, Molecular Pharmacology.

Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle

G. A. Frank, A. Bartesaghi, M. Borgnia, 2016, Molecular Pharmacology.

The A‐loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding

Z. Sauna, S. Ambudkar, D. Xia, 2006, FEBS letters.

Reconstitution of a passive Ca2+-transport pathway from the basolateral plasma membrane of rat parotid gland acinar cells

S. Ambudkar, I. Ambudkar, T. Lockwich, 1995, The Journal of Membrane Biology.

A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein

Olivia W. Lee, M. Gottesman, M. Hall, 2019, Molecular Pharmacology.

A High-Throughput Screen of a Library of Therapeutics Identifies Substrates of P-glycoprotein

Olivia W. Lee, M. Gottesman, M. Hall, 2019, bioRxiv.

Modulatory effects of plant phenols on human multidrug‐resistance proteins 1, 4 and 5 (ABCC1, 4 and 5)

S. Hladky, M. Barrand, A. Calcagno, 2005, The FEBS journal.

Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes

C. D. Salcido, N. Caplen, S. Bates, 2008, British Journal of Cancer.

Brca1 breast tumors contain distinct CD44+/CD24- and CD133+ cells with cancer stem cell characteristics

C. D. Salcido, A. Calcagno, S. Ambudkar, 2008, Breast Cancer Research.

Silent (synonymous) SNPs: should we care about them?

Ryan Hunt, Chava Kimchi-Sarfaty, Zuben E Sauna, 2009, Methods in molecular biology.

Multidrug Resistance in Cancer: A Tale of ABC Drug Transporters

S. Ambudkar, K. Kapoor, Hong‐May Sim, 2013 .

Effects of phosphorylation of P-glycoprotein on multidrug resistance

I. Pastan, M. Gottesman, S. Ambudkar, 1995, Journal of bioenergetics and biomembranes.

Multidrug Resistance–Linked Gene Signature Predicts Overall Survival of Patients with Primary Ovarian Serous Carcinoma

Jean-Pierre Gillet, Sudhir Varma, Anil K Sood, 2012, Clinical Cancer Research.

Silent polymorphisms speak: how they affect pharmacogenomics and the treatment of cancer.

Chava Kimchi-Sarfaty, Zuben E Sauna, Michael M Gottesman, 2007, Cancer research.

Large-scale purification of functional human P-glycoprotein (ABCB1).

S. Ambudkar, S. Shukla, Sabrina Lusvarghi, 2019, Protein expression and purification.

Relation Between the Turnover Number for Vinblastine Transport and for Vinblastine-stimulated ATP Hydrolysis by Human P-glycoprotein*

S. Ambudkar, W. Stein, C. Cardarelli, 1997, The Journal of Biological Chemistry.

Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.

I. Pastan, M. Ramachandra, S. Ambudkar, 1996, Molecular biology of the cell.

Multidrug Resistance Transporter

I. Pastan, M. Gottesman, S. Ambudkar, 1996 .

Heterologous expression systems for P-glycoprotein:E. coli, yeast, and baculovirus

I. Pastan, M. Gottesman, S. Ambudkar, 1995, Journal of bioenergetics and biomembranes.

Screening Compounds with a Novel High-Throughput ABCB1-Mediated Efflux Assay Identifies Drugs with Known Therapeutic Targets at Risk for Multidrug Resistance Interference

S. Ambudkar, Luowei Li, S. Yuspa, 2013, PloS one.

The Phosphodiesterase-5 Inhibitor Vardenafil Is a Potent Inhibitor of ABCB1/P-Glycoprotein Transporter

X. An, P. Ding, S. Ambudkar, 2011, PloS one.

Tyrosine kinase inhibitors as modulators of ABC transporter-mediated drug resistance.

S. Ambudkar, Zhe-Sheng Chen, S. Shukla, 2012, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Tivantinib, A c-Met Inhibitor in Clinical Trials, Is Susceptible to ABCG2-Mediated Drug Resistance

S. Ambudkar, Zhe-Sheng Chen, Dong-Hua Yang, 2020, Cancers.

Ultrastructure, pharmacologic inhibition, and transport selectivity of aquaporin channel-forming integral protein in proteoliposomes.

P. Agre, S. Nielsen, S. Ambudkar, 1994, Biochemistry.

Mechanistic and Pharmacological Insights into Modulation of ABC Drug Transporters by Tyrosine Kinase Inhibitors

S. Ambudkar, S. Shukla, Atish Patel, 2016 .

Comparison of drug transporter levels in normal colon, colon cancer, and Caco-2 cells: impact on drug disposition and discovery.

M. Gottesman, J. Fostel, J. Ludwig, 2006, Molecular pharmaceutics.

Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance.

S. Bates, R. Robey, S. Ambudkar, 2011, Cancer research.

Sensitization of ABCB1 overexpressing cells to chemotherapeutic agents by FG020326 via binding to ABCB1 and inhibiting its function.

S. Akiyama, S. Ambudkar, Zhe-Sheng Chen, 2009, Biochemical pharmacology.

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein.

I. Pastan, M. Gottesman, M. Ramachandra, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and characterization of a BODIPY conjugate of the BCR-ABL kinase inhibitor Tasigna (nilotinib): evidence for transport of Tasigna and its fluorescent derivative by ABC drug transporters.

Suneet Shukla, Michael M Gottesman, M. Gottesman, 2011, Molecular pharmaceutics.

The Inhibitor Ko143 Is Not Specific for ABCG2

M. Gottesman, J. Mulder, M. Hall, 2015, The Journal of Pharmacology and Experimental Therapeutics.

The "specific" P-glycoprotein inhibitor Tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2).

M. Gottesman, M. Hall, C. Halldin, 2011, ACS chemical neuroscience.

Botryllamides: natural product inhibitors of ABCG2.

Suneet Shukla, Kentaro Takada, Curtis J Henrich, 2009, ACS chemical biology.

Sunitinib (Sutent, SU11248), a Small-Molecule Receptor Tyrosine Kinase Inhibitor, Blocks Function of the ATP-Binding Cassette (ABC) Transporters P-Glycoprotein (ABCB1) and ABCG2

Suneet Shukla, S. Bates, R. Robey, 2009, Drug Metabolism and Disposition.

Association of the ABCG2 C421A polymorphism with prostate cancer risk and survival

S. Steinberg, R. Robey, S. Ambudkar, 2008, BJU international.

Role of the ABCG2 drug transporter in the resistance and oral bioavailability of a potent cyclin-dependent kinase/Aurora kinase inhibitor

A. Calcagno, S. Ambudkar, S. Emanuel, 2006, Molecular Cancer Therapeutics.

The calcium channel blockers, 1,4-dihydropyridines, are substrates of the multidrug resistance-linked ABC drug transporter, ABCG2.

Suneet Shukla, S. Bates, R. Robey, 2006, Biochemistry.

Identification of Compounds that Correlate with ABCG2 Transporter Function in the National Cancer Institute Anticancer Drug Screen

Suneet Shukla, S. Bates, S. Holbeck, 2009, Molecular Pharmacology.

Evidence for dual mode of action of a thiosemicarbazone, NSC73306: a potent substrate of the multidrug resistance–linked ABCG2 transporter

Suneet Shukla, Michael M Gottesman, Matthew D Hall, 2007, Molecular Cancer Therapeutics.

Curcumin Inhibits the Activity of ABCG2/BCRP1, a Multidrug Resistance-Linked ABC Drug Transporter in Mice

J. Ware, S. Ambudkar, S. Shukla, 2009, Pharmaceutical Research.

The linker region of breast cancer resistance protein ABCG2 is critical for coupling of ATP-dependent drug transport

S. Bates, A. di Pietro, R. Robey, 2015, Cellular and Molecular Life Sciences.

Tyrphostin RG14620 selectively reverses ABCG2-mediated multidrug resistance in cancer cell lines.

C. Hsieh, S. Ambudkar, Chung-Pu Wu, 2017, Cancer letters.

Discovering natural product modulators to overcome multidrug resistance in cancer chemotherapy.

S. Ambudkar, S. Ohnuma, Suresh V Ambudkar, 2011, Current pharmaceutical biotechnology.

Comparison of ATP-Binding Cassette Transporter Interactions with the Tyrosine Kinase Inhibitors Imatinib, Nilotinib, and Dasatinib

S. Bates, R. Robey, S. Ambudkar, 2010, Drug Metabolism and Disposition.

ARRY‐334543 Reverses Multidrug Resistance by Antagonizing the Activity of ATP‐Binding Cassette Subfamily G Member 2

S. Ambudkar, Zhe-Sheng Chen, R. Xu, 2014, Journal of cellular biochemistry.

The multi-targeted tyrosine kinase inhibitor SKLB610 resensitizes ABCG2-overexpressing multidrug-resistant cancer cells to chemotherapeutic drugs.

T. Hung, S. Ambudkar, Chung-Pu Wu, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

The third-generation EGFR inhibitor almonertinib (HS-10296) resensitizes ABCB1-overexpressing multidrug-resistant cancer cells to chemotherapeutic drugs.

T. Hung, S. Ambudkar, Chung-Pu Wu, 2021, Biochemical pharmacology.

A Combination of Curcumin with Either Gramicidin or Ouabain Selectively Kills Cells That Express the Multidrug Resistance-linked ABCG2 Transporter*

S. Ambudkar, Haiyan Liu, Michael Mayer, 2014, The Journal of Biological Chemistry.

PD173074, a selective FGFR inhibitor, reverses ABCB1-mediated drug resistance in cancer cells

S. Ambudkar, Zhe-Sheng Chen, A. Tiwari, 2013, Cancer Chemotherapy and Pharmacology.

Modulation of the function of the multidrug resistance–linked ATP-binding cassette transporter ABCG2 by the cancer chemopreventive agent curcumin

Suneet Shukla, S. Ambudkar, S. Shukla, 2006, Molecular Cancer Therapeutics.

BMS-599626, a Highly Selective Pan-HER Kinase Inhibitor, Antagonizes ABCG2-Mediated Drug Resistance

S. Ambudkar, Zhe-Sheng Chen, J. Wurpel, 2020, Cancers.

Characterization of Phosphorylation-defective Mutants of Human P-glycoprotein Expressed in Mammalian Cells (*)

I. Pastan, M. Gottesman, S. Ambudkar, 1996, The Journal of Biological Chemistry.

Tetrahydroquinoline/4,5‐Dihydroisoxazole Molecular Hybrids as Inhibitors of Breast Cancer Resistance Protein (BCRP/ABCG2)

A. Poso, T. Kronenberger, S. Ambudkar, 2021, ChemMedChem.

Regorafenib antagonizes BCRP-mediated multidrug resistance in colon cancer.

S. Ambudkar, Zhe-Sheng Chen, S. Shukla, 2019, Cancer letters.

WHI-P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2-overexpressing cells

S. Ambudkar, Zhe-Sheng Chen, L. Fu, 2014, Cancer science.

Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database

Gabriel S. Eichler, J. Weinstein, Y. Pommier, 2009, Molecular Cancer Therapeutics.

New inhibitors of ABCG2 identified by high-throughput screening

Michael Dean, Suneet Shukla, Curtis J Henrich, 2007, Molecular Cancer Therapeutics.

New inhibitors of ABCG 2 identified by high-throughput screening

S. Bates, J. Mcmahon, C. J. Henrich, 2007 .

Correlation between Steady-state ATP Hydrolysis and Vanadate-induced ADP Trapping in Human P-glycoprotein

Z. Sauna, S. Ambudkar, K. Kerr, 2001, The Journal of Biological Chemistry.

Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein.

Z. Sauna, S. Ambudkar, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Polyoxovanadates as new P‐glycoprotein inhibitors: insights into the mechanism of inhibition

S. Ambudkar, D. Mitchell, E. D. de Souza, 2021, FEBS letters.

Mechanistic basis of breast cancer resistance protein inhibition by new indeno[1,2-b]indoles

S. Ambudkar, J. Jose, F. Rego, 2021, Scientific Reports.

Avapritinib: A Selective Inhibitor of KIT and PDGFRα that Reverses ABCB1 and ABCG2-Mediated Multidrug Resistance in Cancer Cell Lines.

T. Hung, S. Ambudkar, Jyun-Cheng Wang, 2019, Molecular pharmaceutics.

The Selective Class IIa Histone Deacetylase Inhibitor TMP195 Resensitizes ABCB1- and ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Cytotoxic Anticancer Drugs

T. Hung, S. Ambudkar, Jyun-Cheng Wang, 2019, International journal of molecular sciences.

Motesanib (AMG706), a potent multikinase inhibitor, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1.

S. Ambudkar, Zhe-Sheng Chen, S. Shukla, 2014, Biochemical pharmacology.

Molecular mechanisms of drug resistance in single-step and multi-step drug-selected cancer cells.

A. Calcagno, S. Ambudkar, 2010, Methods in molecular biology.

Plasma membrane calcium ATPase (PMCA4): A housekeeper for RT-PCR relative quantification of polytopic membrane proteins

A. Calcagno, S. Ambudkar, Suresh V Ambudkar, 2006, BMC Molecular Biology.

Vitro, in Vivo and ex Vivo

Liwu Fu, S. Ambudkar, Zhe-Sheng Chen, 2012 .

Regorafenib overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter in colorectal cancer: In vitro and in vivo study.

S. Ambudkar, Zhe-Sheng Chen, S. Shukla, 2017, Cancer letters.

Residues forming the gating regions of asymmetric multidrug transporter Pdr5 also play roles in conformational switching and protein folding

S. Ambudkar, L. Schmitt, Lucas Restrepo, 2022, The Journal of biological chemistry.

Overview: ABC Transporters and Human Disease

M. Gottesman, S. Ambudkar, 2001, Journal of bioenergetics and biomembranes.

Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity*♦

M. Gottesman, J. Shiloach, L. Esser, 2016, The Journal of Biological Chemistry.

ATP-dependent thermostabilization of human P-glycoprotein (ABCB1) is blocked by modulators.

S. Ambudkar, Sabrina Lusvarghi, 2019, The Biochemical journal.

Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis.

I. Pastan, M. Gottesman, S. Ambudkar, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Branebrutinib (BMS-986195), a Bruton’s Tyrosine Kinase Inhibitor, Resensitizes P-Glycoprotein-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Agents

T. Hung, S. Ambudkar, Chung-Pu Wu, 2021, Frontiers in Cell and Developmental Biology.

Overexpression of ATP-binding cassette transporter ABCG2 as a potential mechanism of acquired resistance to vemurafenib in BRAF(V600E) mutant cancer cells.

S. Ambudkar, S. Hsu, Chung-Pu Wu, 2013, Biochemical pharmacology.

The Multidrug Resistance Transporter P-glycoprotein Confers Resistance to Ferroptosis Inducers

M. Gottesman, D. Esposito, R. Robey, 2023, bioRxiv.

Interaction of A3 adenosine receptor ligands with the human multidrug transporter ABCG2.

K. Jacobson, Zhang-Guo Gao, S. Ambudkar, 2022, European journal of medicinal chemistry.

Use of photoimmunoconjugates to characterize ABCB1 in cancer cells

S. Ambudkar, Huang‐Chiao Huang, Barry J. Liang, 2021, Nanophotonics.

Reversing the direction of drug transport mediated by the human multidrug transporter P-glycoprotein

M. Gottesman, S. Durell, S. Ambudkar, 2020, Proceedings of the National Academy of Sciences.

Multidrug transporters: recent insights from cryo-electron microscopy-derived atomic structures and animal models

M. Gottesman, R. Robey, S. Ambudkar, 2020, F1000Research.

Nonsynonymous Mutations in Linker-2 of the Pdr5 Multidrug Transporter Identify a New RNA Stability Element

S. Ambudkar, M. Naldrett, J. Golin, 2019, G3: Genes, Genomes, Genetics.

Selonsertib (GS-4997), an ASK1 inhibitor, antagonizes multidrug resistance in ABCB1- and ABCG2-overexpressing cancer cells.

S. Ambudkar, Zhe-Sheng Chen, Dexin Kong, 2019, Cancer letters.

Human ATP‐binding cassette transporters ABCB1 and ABCG2 confer resistance to histone deacetylase 6 inhibitor ricolinostat (ACY‐1215) in cancer cell lines

S. Ambudkar, Jau-Song Yu, Chung-Pu Wu, 2018, Biochemical pharmacology.

Mapping discontinuous epitopes for MRK-16, UIC2 and 4E3 antibodies to extracellular loops 1 and 4 of human P-glycoprotein

M. Gottesman, S. Durell, S. Ambudkar, 2018, Scientific Reports.

Global alteration of the drug-binding pocket of human P-glycoprotein (ABCB1) by substitution of fifteen conserved residues reveals a negative correlation between substrate size and transport efficiency.

S. Ambudkar, E. Chufán, Shahrooz Vahedi, 2017, Biochemical pharmacology.

Effects of a detergent micelle environment on P-glycoprotein (ABCB1)-ligand interactions

S. Ambudkar, S. Shukla, B. Abel, 2017, The Journal of Biological Chemistry.

Thiazole-valine peptidomimetic (TTT-28) antagonizes multidrug resistance in vitro and in vivo by selectively inhibiting the efflux activity of ABCB1

Bhargav A. Patel, S. Ambudkar, Zhe-Sheng Chen, 2017, Scientific Reports.

Identification of a Cryptic Bacterial Promoter in Mouse (mdr1a) P-Glycoprotein cDNA

M. Gottesman, D. Esposito, M. Hall, 2015, PloS one.

The multidrug transporter Pdr5 on the 25th anniversary of its discovery: an important model for the study of asymmetric ABC transporters.

S. Ambudkar, J. Golin, 2015, The Biochemical journal.

The Inhibitor Ko 143 Is Not Specific for ABCG 2

M. Gottesman, J. Mulder, M. Hall, 2015 .

Evidence for a Molecular Diode-based Mechanism in a Multispecific ATP-binding cassette (ABC) Exporter

S. Ambudkar, R. Ernst, J. Mehla, 2014, The Journal of Biological Chemistry.

Transporter Pdr 5 Residue in the Yeast Multidrug Exporter : Ser-1368 as a Gatekeeping Mechanism in a Multi-specific ABC Evidence for a Molecular Diode-based Membrane

S. Ambudkar, R. Ernst, J. Mehla, 2014 .

Inhibition of multidrug resistance-linked P-glycoprotein (ABCB1) function by 5'-fluorosulfonylbenzoyl 5'-adenosine: evidence for an ATP analogue that interacts with both drug-substrate-and nucleotide-binding sites.

S. Durell, E. Appella, L. Jenkins, 2011, Biochemistry.

Analysis of expression of drug resistance-linked ABC transporters in cancer cells by quantitative RT-PCR.

A. Calcagno, S. Ambudkar, 2010, Methods in molecular biology.

The yeast Pdr5p multidrug transporter: how does it recognize so many substrates?

Leopold May, S. Ambudkar, Suresh V Ambudkar, 2007, Biochemical and biophysical research communications.

About a switch: how P-glycoprotein (ABCB1) harnesses the energy of ATP binding and hydrolysis to do mechanical work

Z. Sauna, S. Ambudkar, 2007, Molecular Cancer Therapeutics.

The power of the pump: mechanisms of action of P-glycoprotein (ABCB1).

In-Wha Kim, Zuben E Sauna, Z. Sauna, 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

A novel way to spread drug resistance in tumor cells: functional intercellular transfer of P-glycoprotein (ABCB1).

M. Gottesman, G. Szakács, Z. Sauna, 2005, Trends in pharmacological sciences.

Disulfiram, an old drug with new potential therapeutic uses for human cancers and fungal infections.

Z. Sauna, S. Ambudkar, S. Shukla, 2005, Molecular bioSystems.

Multidrug Resistance Protein 4 (ABCC4)-mediated ATP Hydrolysis

Z. Sauna, S. Ambudkar, K. Nandigama, 2004, Journal of Biological Chemistry.

Evidence for the Interaction of A3 Adenosine Receptor Agonists at the Drug-Binding Site(s) of Human P-glycoprotein (ABCB1)

S. Durell, K. Jacobson, S. Ambudkar, 2019, Molecular Pharmacology.

Molecular basis of the polyspecificity of P-glycoprotein (ABCB1): recent biochemical and structural studies.

S. Ambudkar, Eduardo E Chufan, Hong-May Sim, 2015, Advances in cancer research.

Evidence for the Vectorial Nature of Drug (Substrate)-stimulated ATP Hydrolysis by Human P-glycoprotein* 210

Z. Sauna, S. Ambudkar, M. Müller, 2001, The Journal of Biological Chemistry.

Synthesis and analysis of polyethylene glycol linked P-glycoprotein-specific homodimers based on (−)-stipiamide

Z. Sauna, S. Ambudkar, M. Andrus, 2001 .

Characterization of the Catalytic Cycle of ATP Hydrolysis by Human P-glycoprotein

Z. Sauna, S. Ambudkar, 2001, The Journal of Biological Chemistry.

The Mechanism of Action of Multidrug-Resistance-Linked P-Glycoprotein

Z. Sauna, S. Ambudkar, K. Kerr, 2001, Journal of bioenergetics and biomembranes.

Functional Characterization of Glycosylation-Deficient Human P-Glycoprotein Using A Vaccinia Virus Expression System

M. Ramachandra, S. Ambudkar, C. Hrycyna, 2000, The Journal of Membrane Biology.

Mechanism of Action of Human P-glycoprotein ATPase Activity

I. Pastan, M. Gottesman, P. Pedersen, 1998, The Journal of Biological Chemistry.

Photoaffinity labeling of human P-glycoprotein: effect of modulator interaction and ATP hydrolysis on substrate binding.

I. Pastan, M. Ramachandra, S. Ambudkar, 1998, Methods in enzymology.

Elf1p, a Member of the ABC Class of ATPases, Functions as a mRNA Export Factor in Schizosacchromyces pombe *

J. Yoon, Z. Sauna, S. Ambudkar, 2002, The Journal of Biological Chemistry.

HIV protease inhibitors interact with ABCC4/MRP4: a basis for unanticipated enhanced cytotoxicity

S. Ekins, J. Schuetz, S. Ambudkar, 2013 .

Multidrug Resistance–Associated Protein Family

S. Ambudkar, M. Müller, 2002 .

Nonequivalence of the Nucleotide Binding Domains of the ArsA ATPase*

Z. Sauna, S. Ambudkar, Yong Jiang, 2005, Journal of Biological Chemistry.

Glesatinib, a c-MET/SMO Dual Inhibitor, Antagonizes P-glycoprotein Mediated Multidrug Resistance in Cancer Cells

S. Ambudkar, Zhe-Sheng Chen, Dong-Hua Yang, 2019, Front. Oncol..

Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane.

M. Gottesman, G. Szakács, S. Akiyama, 2007, Biochemistry.

Anion exchange in bacteria: reconstitution of phosphate: hexose 6-phosphate antiport from Streptococcus lactis.

P. Maloney, S. Ambudkar, 1986, Methods in enzymology.

Reconstitution of phosphate-linked antiport from Streptococcus lactis.

P. Maloney, S. Ambudkar, 1985, Biochemical and biophysical research communications.

Dependence of Multidrug Resistance Protein-Mediated Cyclic Nucleotide Efflux on the Background Sodium Conductance

S. Stojilkovic, S. Ambudkar, K. Kretschmannova, 2010, Molecular Pharmacology.

The amino acid residues of transmembrane helix 5 of multidrug resistance protein CaCdr1p of Candida albicans are involved in substrate specificity and drug transport.

S. Ambudkar, S. Shukla, R. Prasad, 2009, Biochimica et biophysica acta.

Substitution of threonine-1351 in the multidrug transporter Cdr1p of Candida albicans results in hypersusceptibility to antifungal agents and threonine-1351 is essential for synergic effects of calcineurin inhibitor FK520.

S. Ambudkar, S. Shukla, R. Prasad, 2004, The Journal of antimicrobial chemotherapy.

Divergent signature motifs of nucleotide binding domains of ABC multidrug transporter, CaCdr1p of pathogenic Candida albicans, are functionally asymmetric and noninterchangeable.

S. Ambudkar, S. Shukla, R. Prasad, 2010, Biochimica et biophysica acta.

Exome Sequencing of ABCB5 Identifies Recurrent Melanoma Mutations that Result in Increased Proliferative and Invasive Capacities

M. Gottesman, Jimmy Lin, N. Qutob, 2019, The Journal of investigative dermatology.

ABC-transporter upregulation mediates resistance to the CDK7 inhibitors THZ1 and ICEC0942

Simak Ali, G. Sava, L. Buluwela, 2019, Oncogene.

Calcium efflux from Escherichia coli. Evidence for two systems.

S. Ambudkar, B. Rosen, G. Zlotnick, 1984, The Journal of biological chemistry.

Bacterial anion exchange. Use of osmolytes during solubilization and reconstitution of phosphate-linked antiport from Streptococcus lactis.

P. Maloney, S. Ambudkar, 1986, The Journal of biological chemistry.

Characterization of the Lipidome and Biophysical Properties of Membranes from High Five Insect Cells Expressing Mouse P-Glycoprotein

S. Ambudkar, M. J. Moreno, B. Abel, 2021, Biomolecules.

Mutational analysis of ABCG2: role of the GXXXG motif.

Michael Dean, Zuben E Sauna, S. Bates, 2004, Biochemistry.

ABCB1 and ABCG2 Overexpression Mediates Resistance to the Phosphatidylinositol 3-Kinase Inhibitor HS-173 in Cancer Cell Lines

T. Hung, S. Ambudkar, Jau-Song Yu, 2023, Cells.

Disulfiram is a potent modulator of multidrug transporter Cdr1p of Candida albicans.

Suneet Shukla, Zuben E Sauna, Rajendra Prasad, 2004, Biochemical and biophysical research communications.

Drug-protein hydrogen bonds govern the inhibition of the ATP hydrolysis of the multidrug transporter P-glycoprotein.

S. Ambudkar, K. Kapoor, E. Chufán, 2016, Biochemical pharmacology.

Identification of two novel heterodimeric ABC transporters in melanoma: ABCB5β/B6 and ABCB5β/B9

M. Gottesman, S. Ambudkar, J. Gillet, 2023, bioRxiv.

Exploiting Reaction Intermediates of the ATPase Reaction to Elucidate the Mechanism of Transport by P-glycoprotein (ABCB1)*

Z. Sauna, S. Ambudkar, K. Nandigama, 2006, Journal of Biological Chemistry.

A new porphyrin as selective substrate-based inhibitor of breast cancer resistance protein (BCRP/ABCG2).

A. Poso, T. Kronenberger, R. Robey, 2021, Chemico-biological interactions.

Abstract 5614: Tandutinib (MLN518/CT53518) targeted to stem-like cells by inhibiting the function of ATP-binding cassette subfamily G member 2

Liwu Fu, S. Ambudkar, Zhe-Sheng Chen, 2012 .

Catalytic cycle of ATP hydrolysis by P-glycoprotein: evidence for formation of the E.S reaction intermediate with ATP-gamma-S, a nonhydrolyzable analogue of ATP.

Stephan Kopp, In-Wha Kim, Peter Chiba, 2007, Biochemistry.

The signaling interface of the yeast multidrug transporter Pdr5 adopts a cis conformation, and there are functional overlap and equivalence of the deviant and canonical Q-loop residues.

Z. Sauna, S. Ambudkar, D. Xia, 2010, Biochemistry.

The conserved tyrosine residues 401 and 1044 in ATP sites of human P-glycoprotein are critical for ATP binding and hydrolysis: evidence for a conserved subdomain, the A-loop in the ATP-binding cassette.

Zuben E Sauna, Z. Sauna, S. Ambudkar, 2006, Biochemistry.

ABC transporters : biochemical, cellular, and molecular aspects

M. Gottesman, S. Ambudkar, 1998 .

Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug transport.

I. Pastan, M. Gottesman, S. Ambudkar, 1998, Biochemistry.

Biochemical basis of polyvalency as a strategy for enhancing the efficacy of P-glycoprotein (ABCB1) modulators: stipiamide homodimers separated with defined-length spacers reverse drug efflux with greater efficacy.

Z. Sauna, S. Ambudkar, M. Andrus, 2004, Biochemistry.

Characterization of Potent ABCG2 Inhibitor Derived from Chromone: From the Mechanism of Inhibition to Human Extracellular Vesicles for Drug Delivery

A. Poso, T. Kronenberger, S. Ambudkar, 2023, Pharmaceutics.

Using the BacMam Baculovirus System to Study Expression and Function of Recombinant Efflux Drug Transporters in Polarized Epithelial Cell Monolayers

M. Gottesman, S. Ambudkar, K. Fung, 2016, Drug Metabolism and Disposition.

Multiple Transport-Active Binding Sites Are Available for a Single Substrate on Human P-Glycoprotein (ABCB1)

S. Durell, S. Ambudkar, T. Talele, 2013, PloS one.

The Pim kinase inhibitor SGI-1776 decreases cell surface expression of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and drug transport by Pim-1-dependent and -independent mechanisms.

S. Ambudkar, Zhe-Sheng Chen, S. Shukla, 2013, Biochemical pharmacology.

A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy s

S. Thorgeirsson, M. Gottesman, S. Varma, 2016 .

Reconstitution of the lysosomal proton pump.

J. August, P. Maloney, S. Ambudkar, 1987, Proceedings of the National Academy of Sciences of the United States of America.

The synthesis and evaluation of a solution phase indexed combinatorial library of non-natural polyenes for reversal of P-glycoprotein mediated multidrug resistance.

Z. Sauna, S. Ambudkar, M. Andrus, 2000, The Journal of organic chemistry.

Bacterial expression of the linker region of human MDR1 P-glycoprotein and mutational analysis of phosphorylation sites.

I. Pastan, S. Ambudkar, T. Chambers, 1995, Biochemistry.

The Deviant ATP-binding Site of the Multidrug Efflux Pump Pdr5 Plays an Active Role in the Transport Cycle*

S. Ambudkar, C. Furman, J. Mehla, 2013, The Journal of Biological Chemistry.

The Transmission Interface of the Saccharomyces cerevisiae Multidrug Transporter Pdr5: Val-656 Located in Intracellular Loop 2 Plays a Major Role in Drug Resistance

S. Ambudkar, E. Dine, J. Mehla, 2012, Antimicrobial Agents and Chemotherapy.

Mutations Define Cross-talk between the N-terminal Nucleotide-binding Domain and Transmembrane Helix-2 of the Yeast Multidrug Transporter Pdr5

Z. Sauna, S. Ambudkar, S. Cronin, 2008, Journal of Biological Chemistry.

Conserved Asp327 of walker B motif in the N-terminal nucleotide binding domain (NBD-1) of Cdr1p of Candida albicans has acquired a new role in ATP hydrolysis.

S. Ambudkar, S. Shukla, R. Prasad, 2006, Biochemistry.

Functional reconstitution of prokaryote and eukaryote membrane proteins.

P. Maloney, S. Ambudkar, 1989, Archives of biochemistry and biophysics.

The mechanism of glucose 6-phosphate transport by Escherichia coli.

P. Maloney, S. Ambudkar, L. A. Sonna, 1988, The Journal of biological chemistry.

Identification, purification, and reconstitution of OxlT, the oxalate: formate antiport protein of Oxalobacter formigenes.

P. Maloney, S. Ambudkar, V. Anantharam, 1992, The Journal of biological chemistry.

Pharmacophore Modeling of Nilotinib as an Inhibitor of ATP-Binding Cassette Drug Transporters and BCR-ABL Kinase Using a Three-Dimensional Quantitative Structure–Activity Relationship Approach

S. Ambudkar, S. Shukla, T. Talele, 2014, Molecular pharmaceutics.

Mutations in Intracellular Loops 1 and 3 Lead to Misfolding of Human P-glycoprotein (ABCB1) That Can Be Rescued by Cyclosporine A, Which Reduces Its Association with Chaperone Hsp70*

S. Ambudkar, K. Kapoor, E. Chufán, 2013, The Journal of Biological Chemistry.

Natural medicinal compounds target signal transduction pathways to overcome ABC drug efflux transporter-mediated multidrug resistance in cancer.

S. Ambudkar, Andaleeb Sajid, N. Prasad, 2023, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Residues from Homologous Transmembrane Helices 4 and 10 Are Critical for P-Glycoprotein (ABCB1)-Mediated Drug Transport

S. Durell, S. Ambudkar, Andaleeb Sajid, 2023, Cancers.

Synthetic Analogs of Curcumin Modulate the Function of Multidrug Resistance-Linked ABC transporter ABCG2

M. Ishida, M. Unno, S. Ambudkar, 2017 .

Does the ATP‐bound EQ mutant reflect the pre‐ or post‐ATP hydrolysis state in the catalytic cycle of human P‐glycoprotein (ABCB1)?

S. Durell, S. Ambudkar, Sabrina Lusvarghi, 2021, FEBS letters.

Exploiting multidrug resistance to treat cancer.

I. Pastan, M. Gottesman, S. Ambudkar, 1994, Cold Spring Harbor Symposia on Quantitative Biology.

Furmonertinib, a Third-Generation EGFR Tyrosine Kinase Inhibitor, Overcomes Multidrug Resistance through Inhibiting ABCB1 and ABCG2 in Cancer Cells

T. Hung, S. Ambudkar, Chung-Pu Wu, 2023, International journal of molecular sciences.

Advances in the structure, mechanism and targeting of chemoresistance-linked ABC transporters

S. Ambudkar, Andaleeb Sajid, Hadiar Rahman, 2023, Nature Reviews Cancer.

Mapping discontinuous epitopes for MRK-16, UIC2 and 4E3 antibodies to extracellular loops 1 and 4 of human P-glycoprotein

M. Gottesman, S. Durell, S. Ambudkar, 2018, Scientific Reports.

The molecular mechanisms of drug resistance in single-step and multi-step drug-selected cancer cells

A. Calcagno, S. Ambudkar, 2011 .

Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima.

R. Nussinov, Chung-Jung Tsai, M. Gottesman, 2008, Journal of molecular biology.

Bioluminescent imaging of drug efflux at the blood–brain barrier mediated by the transporter ABCG2

R. M. Simpson, M. Gottesman, M. Hall, 2013, Proceedings of the National Academy of Sciences.

Supporting Online Material

Lippincott-Schwartz, S. Edelman, E. Ruppin, 2004 .

Association of the ABCG2 C421A polymorphism with prostate cancer risk and survival

S. Steinberg, R. Robey, S. Ambudkar, 2008, BJU international.

Curcumin Modulates Efflux Mediated by Yeast ABC Multidrug Transporters and Is Synergistic with Antifungals

S. Ambudkar, S. Shukla, T. Prasad, 2009, Antimicrobial Agents and Chemotherapy.

Synergistic with Antifungals Yeast Abc Multidrug Transporters and Is Curcumin Modulates Efflux Mediated By

S. Ambudkar, S. Shukla, R. Manoharlal, 2008 .

Plasma membrane calcium ATPase (PMCA4): A housekeeper for RT-PCR relative quantification of polytopic membrane proteins

A. Calcagno, S. Ambudkar, Chung-Pu Wu, 2006, BMC Molecular Biology.

Mechanism of Action of Human P-glycoprotein ATPase Activity

I. Pastan, M. Gottesman, P. Pedersen, 1998, The Journal of Biological Chemistry.

Use of Baculovirus BacMam Vectors for Expression of ABC Drug Transporters in Mammalian Cells

S. Ambudkar, S. Shukla, K. Kapoor, 2012, Drug Metabolism and Disposition.

Imperatorin Restores Chemosensitivity of Multidrug-Resistant Cancer Cells by Antagonizing ABCG2-Mediated Drug Transport

T. Hung, S. Ambudkar, Chung-Pu Wu, 2023, Pharmaceuticals.

Second-site suppressor mutations reveal connection between the drug-binding pocket and nucleotide-binding domain 1 of human P-glycoprotein (ABCB1).

S. Ambudkar, Andaleeb Sajid, B. Abel, 2023, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Neratinib Reverses ATP-Binding Cassette B1-Mediated Chemotherapeutic Drug Resistance In Vitro, In Vivo, and Ex Vivo

S. Ambudkar, Zhe-Sheng Chen, L. Fu, 2012, Molecular Pharmacology.

A-803467, a tetrodotoxin-resistant sodium channel blocker, modulates ABCG2-mediated MDR in vitro and in vivo

S. Ambudkar, Zhe-Sheng Chen, S. Shukla, 2015, Oncotarget.

New mechanisms of multidrug resistance: an introduction to the Cancer Drug Resistance special collection

M. Gottesman, R. Robey, S. Ambudkar, 2023, Cancer drug resistance.

Divergent signature motifs of nucleotide binding domains of ABC multidrug transporter, CaCdr1p of pathogenic Candida albicans, are functionally asymmetric and noninterchangeable.

S. Ambudkar, S. Shukla, S. Shukla, 2010, Biochimica et biophysica acta.

Sunitinib (Sutent®, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ABC transporters, P-glycoprotein (ABCB1) and ABCG2

R. Robey, S. Ambudkar, S. Shukla, 2008 .

Multidrug Resistance Protein 4 (ABCC4)-mediated ATP Hydrolysis EFFECT OF TRANSPORT SUBSTRATES AND CHARACTERIZATION OF THE POST-HYDROLYSIS TRANSITION STATE*

Z. Sauna, S. Ambudkar, K. Nandigama, 2004 .

Complete inhibition of the Pdr5p multidrug efflux pump ATPase activity by its transport substrate clotrimazole suggests that GTP as well as ATP may be used as an energy source.

Z. Sauna, S. Ambudkar, Z. Kon, 2007, Biochemistry.

MDR1 synonymous polymorphisms alter transporter specificity and protein stability in a stable epithelial monolayer.

M. Gottesman, C. Kimchi-Sarfaty, S. Ambudkar, 2014, Cancer research.

Epidermal Growth Factor Receptor Inhibitor Mobocertinib Resensitizes Multidrug-Resistant Cancer Cells by Attenuating the Human ATP-Binding Cassette Subfamily B Member 1 and Subfamily G Member 2.

T. Hung, S. Ambudkar, Chung-Pu Wu, 2023, ACS pharmacology & translational science.

The positive inotropic agent DPI-201106 selectively reverses ABCB1-mediated multidrug resistance in cancer cell lines.

T. Hung, S. Ambudkar, Chung-Pu Wu, 2018, Cancer letters.