Linda Koch

发表

Pathogen genetics: Making male malaria mosquitoes

Linda Koch, 2016, Nature Reviews Genetics.

Predicting mRNA levels from genome sequence

Linda Koch, 2020, Nature Reviews Genetics.

Alternative splicing: A thermometer controlling gene expression

Linda Koch, 2017, Nature Reviews Genetics.

Epidemiology: Genetic T2DM risk factor found

Linda Koch, 2014, Nature Reviews Endocrinology.

Inactivation of the Fto gene protects from obesity

Jens C. Brüning, Linda Koch, J. Brüning, 2009, Nature.

Technology: DNase Hi-C — pitch-perfect chromatin mapping?

Linda Koch, 2014, Nature Reviews Genetics.

Genetic testing: Whole-exome sequencing for clinical diagnostics

Linda Koch, 2016, Nature Reviews Genetics.

Microbial signatures of colorectal cancer

Linda Koch, 2019, Nature Reviews Genetics.

Complex disease: From non-coding risk variant to biological mechanism in CAD

Linda Koch, 2017, Nature Reviews Genetics.

Genetics: From non-coding risk variant to biological mechanism in CAD

Linda Koch, 2017, Nature Reviews Cardiology.

Genomics: Adding another dimension to gene regulation

Linda Koch, 2015, Nature Reviews Genetics.

Disease genetics: New insights into the genetic architecture of ASDs

Linda Koch, 2014, Nature Reviews Genetics.

Disease genetics: Under pressure — genetics of hypertension

Linda Koch, 2016, Nature Reviews Genetics.

Cancer: RANKL inhibition—a new weapon against breast cancer?

Linda Koch, 2010, Nature Reviews Endocrinology.

Genetic variation: Genetic associations with a social science outcome

Linda Koch, 2016, Nature Reviews Genetics.

Functional genomics: Screening for lncRNA function

Linda Koch, 2017, Nature Reviews Genetics.

Technique: See and seq the regulome

Linda Koch, 2016, Nature Reviews Genetics.

Probing the RNA-protein interface.

Linda Koch, 2020, Nature reviews. Genetics.

Genetic screens: CRISPR knockout screens for human fitness genes

Linda Koch, 2016 .

Vertebroplasty vs kyphoplasty

Linda Koch, 2009, Nature Reviews Endocrinology.

Population genomics: A new window into the genetics of complex diseases

Linda Koch, 2014, Nature Reviews Genetics.

gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor.

H. Münzberg, T. Horvath, M. Shanabrough, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth

M. Blüher, Linda Koch, J. Brüning, 2008, Diabetes.

Diabetes: FFAR1 activation improves glycemia

Linda Koch, 2012, Nature Reviews Endocrinology.

Targeted deletion of somatotroph insulin-like growth factor-I signaling in a cell-specific knockout mouse model.

S. Radovick, Linda Koch, R. Kineman, 2010, Molecular endocrinology.

Genome evolution: To have or have not — recurrent intron loss in plants

Linda Koch, 2015, Nature Reviews Genetics.

Estimating heritability without genetic testing

Linda Koch, 2018, Nature Reviews Genetics.

Altered splicing in Alzheimer transcriptomes

Linda Koch, 2018, Nature Reviews Genetics.

Cardiovascular endocrinology: Cardiovascular risk—general versus abdominal adiposity

Linda Koch, 2011, Nature Reviews Endocrinology.

Genome evolution: Evolutionary insights from comparative bear genomics

Linda Koch, 2014, Nature Reviews Genetics.

Diabetes: Long-term effects of oral antidiabetic agents on C-reactive protein levels

Linda Koch, 2010, Nature Reviews Endocrinology.

What makes us human?

Linda Koch, 2018, Nature Reviews Genetics.

Weight-loss programs compared: diet or medication?

Linda Koch, 2010 .

Obesity: Weight-loss programs compared: diet or medication?

Linda Koch, 2010, Nature Reviews Endocrinology.

Therapy: Bisphosphonate-independent reduction of bone resorption in patients with bone metastases

Linda Koch, 2010, Nature Reviews Endocrinology.

Human evolution: Selection — a balancing act

Linda Koch, 2014, Nature Reviews Genetics.

Disease genomics: Triaging risk variants in the non-coding genome

Linda Koch, 2014, Nature Reviews Genetics.

Inflammation: Intestinal-type alkaline phosphatase—a new therapeutic weapon?

Linda Koch, 2013, Nature Reviews Endocrinology.

Fischer et al. reply

Linda Koch, J. Brüning, U. Rüther, 2010, Nature.

Divergent roles of growth factors in the GnRH regulation of puberty in mice.

C. Kahn, F. Wondisford, S. Radovick, 2010, The Journal of clinical investigation.

Genomics: The best-laid plans of mice and men

Linda Koch, 2014, Nature Reviews Genetics.

Genetic engineering: In vivo genome editing — growing in strength

Linda Koch, 2016, Nature Reviews Genetics.

Bioinformatics: Taking the epigenome to another dimension

Linda Koch, 2016, Nature Reviews Genetics.

Pharmacotherapy: Vandetanib—a new therapeutic option in advanced medullary thyroid cancer

Linda Koch, 2012, Nature Reviews Endocrinology.

Milestone: Meet and greet—insulin and receptor interaction unraveled

Linda Koch, 2013, Nature Reviews Endocrinology.

Technology: Multi-tasking CRISPR RNA scaffolds

Linda Koch, 2015, Nature Reviews Genetics.

Metabolism: Mitochondrial pathways in NAFLD

Linda Koch, 2012, Nature Reviews Endocrinology.

Metagenomics: Pathogen diagnostics for the masses

Linda Koch, 2016, Nature Reviews Genetics.

Genome organization: 3D genome architecture — of loops and globules

Linda Koch, 2014, Nature Reviews Genetics.

Sequencing bears fruit

Linda Koch, 2019, Nature Reviews Genetics.

Pharmacotherapy: Olmesartan for microalbuminuria—friend or foe?

Linda Koch, 2011, Nature Reviews Endocrinology.

Metagenomics: Marine genomics goes viral

Linda Koch, 2016, Nature Reviews Genetics.

Metagenomics: Shaping the gut microbiome

Linda Koch, 2014, Nature Reviews Genetics.

Microbiome: Shaping the gut microbiome

Linda Koch, 2015, Nature Reviews Microbiology.

Toppling TAD tenets

Linda Koch, 2019, Nature Reviews Genetics.

RNA: Translated circular RNAs

Linda Koch, 2017, Nature Reviews Genetics.

Cell fate engineering through TF activation.

Linda Koch, 2020, Nature reviews. Genetics.

The origin of animals and fungi

Linda Koch, 2022, Nature Reviews Genetics.

Chromosome interaction hubs around nuclear bodies

Linda Koch, 2018, Nature Reviews Genetics.

Transcriptomics in intact tissues

Linda Koch, 2018, Nature Reviews Genetics.

Genetic Analysis of Insulin and Insulin-like Growth Factor-1 Signaling in the Central Nervous System

Linda Koch, 2008 .

The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry

Simon Hess, Olivier Elemento, Thomas Franz, 2013, Nature Neuroscience.

Chromatin: Going a TAD out on a limb

Linda Koch, 2016, Nature Reviews Genetics.

Carbon-sulfur bond cleavage at an electrophilic zirconium center: synthesis, structure, and thermal decomposition of [Cp2Zr(S-tert-C4H9)(THF)][BPh4]

Linda Koch, M. Zaworotko, L. MacGillivray, 1992 .

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.

F. Ashcroft, Xiaosong Ma, T. Mak, 2006, The Journal of clinical investigation.

Neuronal IGF‐1 resistance reduces Aβ accumulation and protects against premature death in a model of Alzheimer's disease

T. Kadowaki, Linda Koch, N. Kubota, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

IGF-IR signaling attenuates the age-related decline of diastolic cardiac function.

K. Köhrer, Linda Koch, J. Brüning, 2012, American journal of physiology. Endocrinology and metabolism.

Epigenomics: Sperm as obesity propagator?

Linda Koch, Linda Koch, 2015, Nature Reviews Genetics.

Neuroendocrinology: Improved progression-free survival with everolimus plus octreotide in carcinoid syndrome

Linda Koch, 2012, Nature Reviews Endocrinology.

Pharmacotherapy: Somatoprim versus octreotide in acromegaly

Linda Koch, 2012, Nature Reviews Endocrinology.

Non-coding RNA: A protective role for TERRA at telomeres

Linda Koch, 2017, Nature Reviews Genetics.

Diabetes: Retinopathy: a surrogate measure of T2DM duration

Linda Koch, 2011, Nature Reviews Endocrinology.

Epidermal insulin/IGF‐1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation

Linda Koch, J. Brüning, C. Wickenhauser, 2008, The EMBO journal.

Obesity: Rare copy number variants are associated with severe early-onset obesity

Linda Koch, 2010, Nature Reviews Endocrinology.

Baby sequencing steps

Linda Koch, 2019, Nature Reviews Genetics.

Biomarker benchmarking

Linda Koch, Linda Koch, 2022, Nature Reviews Genetics.

Charting the world’s microbiomes

Linda Koch, 2022, Nature reviews genetics.

Thyroid gland: Teratogenic effects of antithyroid drugs

Linda Koch, 2010, Nature Reviews Endocrinology.

Epigenetics: An epigenetic twist on the missing heritability of complex traits

Linda Koch, 2014, Nature Reviews Genetics.

Development: Epigenome dynamics from seed to seedling

Linda Koch, 2017, Nature Reviews Genetics.

Phosphoinositide-Dependent Kinase 1 Provides Negative Feedback Inhibition to Toll-Like Receptor-Mediated NF-κB Activation in Macrophages

J. Mauer, Linda Koch, J. Brüning, 2010, Molecular and Cellular Biology.

Disease genetics: tRNA splicing defect underlies brain disorder

Linda Koch, 2014, Nature Reviews Genetics.

Non-coding RNA: MicroRNA stimulates mitochondrial translation

Linda Koch, 2014, Nature Reviews Genetics.

Exploring human genomic diversity with gnomAD

Linda Koch, Linda Koch, 2020, Nature Reviews Genetics.

Base editing takes a shot at disease in non-human primates

Linda Koch, 2021, Nature Reviews Genetics.

Gene therapy: Genome editing in haematopoietic stem cells

Linda Koch, 2014, Nature Reviews Genetics.

Central insulin action regulates peripheral glucose and fat metabolism in mice.

C. Kahn, Linda Koch, A. C. Könner, 2008, The Journal of clinical investigation.

New Endocrine Society guidelines for hyperprolactinemia—piecing together the pituitary puzzle

Linda Koch, 2011, Nature Reviews Endocrinology.

Disease genetics: Insights into missing heritability

Linda Koch, Linda Koch, 2014, Nature Reviews Genetics.

Nutrition: Soy food intake and breast cancer

Linda Koch, 2010, Nature Reviews Endocrinology.

Chromosome interaction hubs around nuclear bodies

Linda Koch, 2018, Nature Reviews Genetics.

Cancer genomics: The driving force of cancer evolution

Linda Koch, 2017, Nature Reviews Genetics.

Neuroendocrinology: FGF21—central pathways of action unravelled

Linda Koch, 2013, Nature Reviews Endocrinology.

Nutrition: New diabetes nutrition recommendations—food for thought

Linda Koch, 2013, Nature Reviews Endocrinology.

DNA replication in cell fate reprogramming

Linda Koch, 2022, Nature Reviews Genetics.

Growth hormone in health and disease: Consensus guidelines for GH therapy in Prader—Willi syndrome—this way forward?

Linda Koch, 2013, Nature Reviews Endocrinology.

Bone: Osteoporosis screening intervals

Linda Koch, 2012, Nature Reviews Endocrinology.

Long-read sequencing of new Drosophila genomes

Linda Koch, 2021, Nature Reviews Genetics.

Genomic transformations of Eurasian hunter-gatherer populations during the last Ice Age

Linda Koch, 2023, Nature reviews genetics.

Nutrition: Risk of T1DM increases with early and late weaning

Linda Koch, 2013, Nature Reviews Endocrinology.

Diabetes: RAGE links genes and environmental factors in type 1 diabetes mellitus

Linda Koch, 2011, Nature Reviews Endocrinology.

A panoramic view of mouse organogenesis

Linda Koch, 2022, Nature Reviews Genetics.

Reproductive endocrinology: Macrosomia in developing countries

Linda Koch, 2013, Nature Reviews Endocrinology.

Chromatin control by H1 histones

Linda Koch, 2020, Nature reviews. Genetics.

Therapy: Propylthiouracil use associated with severe hepatotoxicity in children

Linda Koch, 2010, Nature Reviews Endocrinology.

Thrifty Phenotype: Effect of Gender Glycerol-3-phosphate Dehydrogenase Gene Exhibit a Mice with Deletion of the Mitochondrial Diet-sensitive Obesity Enhanced Pip3 Signaling in Pomc Neurons Causes Katp Channel Activation and Leads To

F. Ashcroft, C. Bouchard, Xiaosong Ma, 2006 .

Disease genetics: Therapeutic targeting of a long non-coding RNA

Linda Koch, 2014, Nature reviews genetics.

Genetics: AIP mutations in young patients with sporadic pituitary macroadenoma

Linda Koch, 2011, Nature Reviews Endocrinology.

Technology: Let there be light—new implantable hydrogels for in vivo optical sensing and therapy

Linda Koch, 2013, Nature Reviews Endocrinology.

Cancer genomics: A catalogue of somatic mutations

Linda Koch, Linda Koch, 2016, Nature Reviews Genetics.

Pharmacotherapy: Levothyroxine in the elderly—finding the breaking point

Linda Koch, 2011, Nature Reviews Endocrinology.

Transcriptional profiling of physically interacting cells

Linda Koch, 2020, Nature reviews genetics.

A deep learning method to map tissue architecture

Linda Koch, 2022, Nature reviews genetics.

Epigenetics: Dad's diet controls offspring phenotype

Linda Koch, 2014, Nature Reviews Genetics.

Epidermal insulin/IGF‐1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation

Linda Koch, J. Brüning, C. Wickenhauser, 2008, The EMBO journal.

Genetic engineering: Pigs without PERVs

Linda Koch, 2017, Nature reviews genetics.

Cancer genetics: A 3D view of genome rearrangements

Linda Koch, 2017, Nature Reviews Genetics.

RNA: The code in the cap

Linda Koch, 2016, Nature Reviews Genetics.

Regulatory elements: A boost to RNA processing

Linda Koch, 2017, Nature Reviews Genetics.

Obesity: Taranabant no longer developed as an antiobesity agent

Linda Koch, 2010, Nature Reviews Endocrinology.

Cancer: Postablative thyroglobulin levels predict recurrence of thyroid cancer

Linda Koch, 2010, Nature Reviews Endocrinology.

IGF-IR signaling attenuates the age-related decline of diastolic cardiac function.

K. Köhrer, Linda Koch, J. Brüning, 2012, American journal of physiology. Endocrinology and metabolism.

Evolution to the rescue

Linda Koch, 2019, Nature Reviews Genetics.

Capturing transposases for new proteins

Linda Koch, 2021, Nature Reviews Genetics.

Development: Cell fate decisions in mammalian embryogenesis

Linda Koch, 2014, Nature Reviews Genetics.

Animal models: High-precision gene editing in monkeys is feasible

Linda Koch, 2014, Nature Reviews Genetics.

Diabetes: Individualized HbA1c targets in elderly patients with T2DM

Linda Koch, 2013, Nature Reviews Endocrinology.

Early-life antibiotic use and gut microbiota

Linda Koch, 2019, Nature Reviews Genetics.

Cancer: Long-term use of metformin could protect against breast cancer

Linda Koch, 2010, Nature Reviews Endocrinology.

Same genomes, but different

Linda Koch, 2021, Nature Reviews Genetics.

Bone: Subclinical hypercortisolism raises vertebral fracture risk

Linda Koch, 2011, Nature Reviews Endocrinology.