B. Nadal-Ginard

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Alternative splicing in the control of gene expression.

J. G. Patton, C. W. Smith, B. Nadal-Ginard, 1989, Annual review of genetics.

Statins Stimulate New Myocyte Formation After Myocardial Infarction by Activating Growth and Differentiation of the Endogenous Cardiac Stem Cells

D. Torella, G. Cuda, B. Nadal-Ginard, 2020, International journal of molecular sciences.

Activation of the myogenic lineage by MEF2A, a factor that induces and cooperates with MyoD.

B. Nadal-Ginard, J. Schneider, S. Kaushal, 1994, Science.

A matter of life and death: cardiac myocyte apoptosis and regeneration.

P. Anversa, A. Leri, B. Nadal-Ginard, 2003, The Journal of clinical investigation.

Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration

D. Torella, M. Rota, P. Anversa, 2003, Cell.

Alternative splicing: a ubiquitous mechanism for the generation of multiple protein isoforms from single genes.

B. Nadal-Ginard, A. Andreadis, R. Breitbart, 1987, Annual review of biochemistry.

The use and abuse of Cre/Lox recombination to identify adult cardiomyocyte renewal rate and origin

C. Indolfi, D. Torella, B. Nadal-Ginard, 2018, Pharmacological research.

Molecular basis of functional myogenic specification of Bona Fide multipotent adult cardiac stem cells

D. Torella, B. Nadal-Ginard, E. Cianflone, 2018, Cell cycle.

Isolation and characterization of resident endogenous c-Kit+ cardiac stem cells from the adult mouse and rat heart

D. Torella, B. Nadal-Ginard, A. Nocera, 2014, Nature Protocols.

Myocyte death and renewal: modern concepts of cardiac cellular homeostasis

D. Torella, I. Karakikes, B. Nadal-Ginard, 2007, Nature Clinical Practice Cardiovascular Medicine.

Cardiovascular development: towards biomedical applicability

D. Torella, I. Karakikes, B. Nadal-Ginard, 2007, Cellular and Molecular Life Sciences.

Cardiac stem and progenitor cell biology for regenerative medicine.

C. Indolfi, D. Torella, B. Nadal-Ginard, 2005, Trends in cardiovascular medicine.

Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation

M. Blasco, S. Franco, P. Anversa, 2003, The EMBO journal.

Bone marrow cells regenerate infarcted myocardium

David M. Bodine, R. McKay, D. Bodine, 2001, Nature.

Mobilized bone marrow cells repair the infarcted heart, improving function and survival

Federica Limana, David M. Bodine, D. Bodine, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome.

L. Leinwand, T. Shows, B. Nadal-Ginard, 1983, Science.

Fast skeletal muscle myosin light chains 1 and 3 are produced from a single gene by a combined process of differential RNA transcription and splicing.

B. Nadal-Ginard, E. Strehler, M. Periasamy, 1984, The Journal of biological chemistry.

Myosin light-chain 1 and 3 gene has two structurally distinct and differentially regulated promoters evolving at different rates.

B. Nadal-Ginard, E. Strehler, M. Periasamy, 1985, Molecular and cellular biology.

The rat alpha-tropomyosin gene generates a minimum of six different mRNAs coding for striated, smooth, and nonmuscle isoforms by alternative splicing

C. W. Smith, B. Nadal-Ginard, D. Wieczorek, 1988, Molecular and cellular biology.

Myosin light-chain 1/3 gene alternative splicing: cis regulation is based upon a hierarchical compatibility between splice sites

B. Nadal-Ginard, M. Gallego, 1990, Molecular and cellular biology.

USE OF AFFINITY CHROMATOGRAPHY FOR PURIFICATION OF LACTATE DEHYDROGENASE AND FOR ASSESSING THE HOMOLOGY AND FUNCTION OF THE A AND B SUBUNITS

C. Markert, B. Nadal-Ginard, 1975 .

A MyoD1-independent muscle-specific enhancer controls the expression of the beta-myosin heavy chain gene in skeletal and cardiac muscle cells.

B. Nadal-Ginard, V. Mahdavi, W. R. Thompson, 1991, The Journal of biological chemistry.

Reversal of myogenic terminal differentiation by SV40 large T antigen results in mitosis and apoptosis.

B. Nadal-Ginard, T. Endo, Bernardo Nadal-Ginard, 1998, Journal of cell science.

Bone Marrow Cells Differentiate in Cardiac Cell Lineages After Infarction Independently of Cell Fusion

D. Torella, C. Bearzi, M. Rota, 2004, Circulation research.

There types of muscle-specific gene expression in fusion-blocked rat skeletal muscle cells: Translational control in EGTA-treated cells

B. Nadal-Ginard, T. Endo, 1987, Cell.

Atrial myxomas arise from multipotent cardiac stem cells

G. Viglietto, D. Torella, P. Veltri, 2020, European heart journal.

Cardiac myosin heavy chain isozymic transitions during development and under pathological conditions are regulated at the level of mRNA availability.

B. Nadal-Ginard, V. Mahdavi, A. Lompré, 1984, European heart journal.

Cardiac alpha- and beta-myosin heavy chain genes are organized in tandem.

B. Nadal-Ginard, V. Mahdavi, A. Chambers, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Facteur 2 activant la transcription specifique du myocyte

B. Nadal-Ginard, 1993 .

The effect of diabetes and poor left ventricular function on bone marrow cell-induced myocardial protection.

B. Nadal-Ginard, M. Galiñanes, A. Treumann, 2012, The Journal of surgical research.

Canine Ventricular Myocytes Possess a Renin-Angiotensin System That Is Upregulated With Heart Failure

P. Anversa, A. Leri, L. Barlucchi, 2001, Circulation research.

Molecular cardiomyoplasty: potential cardiac gene therapy for chronic heart failure.

W. Gu, B. Nadal-Ginard, S. K. Tam, 1995, The Journal of thoracic and cardiovascular surgery.

Senescence and Death of Primitive Cells and Myocytes Lead to Premature Cardiac Aging and Heart Failure

D. Torella, A. Maseri, C. Colussi, 2003, Circulation research.

Development and Characterization of a Cloned Rat Pulmonary Arterial Smooth Muscle Cell Line That Maintains Differentiated Properties Through Multiple Subcultures

B. Nadal-Ginard, B. Berk, T. Kulik, 1992, Circulation.

Myocardial Cell Death in Human Diabetes

A. Maseri, P. Anversa, A. Leri, 2000, Circulation research.

bcl-2 overexpression promotes myocyte proliferation

P. Anversa, A. Leri, B. Nadal-Ginard, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Multiple Positive and Negative 5′ Regulatory Elements Control the Cell-Type-Specific Expression of the Embryonic Skeletal Myosin Heavy-Chain Gene

B. Nadal-Ginard, E. Strehler, V. Mahdavi, 1987, Molecular and cellular biology.

Isolation and characterization of human myosin heavy chain genes.

L. Leinwand, B. Nadal-Ginard, E. McNally, 1983, Proceedings of the National Academy of Sciences of the United States of America.

In vitro CSC-derived cardiomyocytes exhibit the typical microRNA-mRNA blueprint of endogenous cardiomyocytes

Domenico A. Palumbo, D. Torella, P. Veltri, 2021, Communications biology.

The Absence of Evidence Is Not Evidence of Absence : The Pitfalls of Cre Knock-Ins in the C-Kit Locus

D. Torella, B. Nadal-Ginard, G. Ellison, 2014 .

Generation of new cardiomyocytes after injury: de novo formation from resident progenitors vs. replication of pre-existing cardiomyocytes.

C. Indolfi, D. Torella, B. Nadal-Ginard, 2015, Annals of translational medicine.

Kitcre knock-in mice fail to fate-map cardiac stem cells

C. Indolfi, D. Torella, D. Saur, 2018, Nature.

Bone marrow cells have a potent anti-ischemic effect against myocardial cell death in humans.

B. Nadal-Ginard, C. Kubal, M. Galiñanes, 2006, The Journal of thoracic and cardiovascular surgery.

Transplantation of Allogeneic PW 1 pos / Pax 7 neg Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle

B. Nadal-Ginard, P. Dankers, D. Sassoon, 2017 .

Transplantation of Allogeneic PW1pos/Pax7neg Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle

B. Nadal-Ginard, P. Dankers, D. Sassoon, 2017, JACC. Basic to translational science.

Porcine Skeletal Muscle‐Derived Multipotent PW1pos/Pax7neg Interstitial Cells: Isolation, Characterization, and Long‐Term Culture

B. Nadal-Ginard, D. Sassoon, F. Lewis, 2014, Stem cells translational medicine.

Factor-Stimulated Vascular Smooth Muscle Cells

B. Rollins, B. Nadal-Ginard, B. Berk, 2005 .

Cardiac chimerism: methods matter.

P. Anversa, B. Nadal-Ginard, 2002, Circulation.

[Generation of new cardiomyocytes in the adult heart: Prospects of myocardial regeneration as an alternative to cardiac transplantation].

B. Nadal-Ginard, 2001, Revista espanola de cardiologia.

Comparison of α-tropomyosin sequences from smooth and striated muscle

B. Nadal-Ginard, N. Ruiz‐Opazo, J. Weinberger, 1985, Nature.

A retinoic acid-responsive element in the apolipoprotein AI gene distinguishes between two different retinoic acid response pathways

J. Rottman, B. Nadal-Ginard, S. Karathanasis, 1991, Molecular and cellular biology.

Characterization of a developmentally regulated perinatal myosin heavy-chain gene expressed in skeletal muscle.

B. Nadal-Ginard, M. Periasamy, D. Wieczorek, 1984, The Journal of biological chemistry.

Thyroid hormone induces a nerve-independent precocious expression of fast myosin heavy chain mRNA in rat hindlimb skeletal muscle.

B. Nadal-Ginard, R. Whalen, N. Cambon, 1988, The Journal of biological chemistry.

Characterization of sarcomeric myosin heavy chain genes.

B. Nadal-Ginard, H. Nguyen, R. Gubits, 1983, The Journal of biological chemistry.

Rapid and reversible changes in myosin heavy chain expression in response to increased neuromuscular activity of rat fast‐twitch muscle

B. Nadal-Ginard, S. Izumo, D. Pette, 1990, FEBS letters.

Inhibition of in vitro myogenic differentiation by cellular transcription factor E2F1.

B. Nadal-Ginard, P. Jin, K. Helin, 1995, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

JE mRNA accumulates rapidly in aortic injury and in platelet-derived growth factor-stimulated vascular smooth muscle cells.

B. Rollins, B. Nadal-Ginard, B. Berk, 1992, Circulation research.

Cardiac Myocyte Terminal Differentiation

W. Gu, B. Nadal-Ginard, V. Mahdavi, 1995 .

The expression of sarcomeric muscle-specific contractile protein genes in BC3H1 cells: BC3H1 cells resemble skeletal myoblasts that are defective for commitment to terminal differentiation

C. W. Smith, B. Nadal-Ginard, S. Izumo, 1989, The Journal of cell biology.

Cloning and characterization of mammalian myosin regulatory light chain (RLC) cDNA: the RLC gene is expressed in smooth, sarcomeric, and nonmuscle tissues

B. Nadal-Ginard, M. Taubman, J. Grant, 1987, The Journal of cell biology.

Developmentally induced, muscle-specific trans factors control the differential splicing of alternative and constitutive troponin T exons

B. Nadal-Ginard, R. Breitbart, 1987, Cell.

Trypanosoma cruzi: reversal of inhibition of host muscle differentiation after exposure to elevated temperatures.

B. Nadal-Ginard, H. Tanowitz, M. Wittner, 1984, Experimental parasitology.

Transcriptional and Posttranscriptional Control of c-myc during Myogenesis: Its mRNA Remains Inducible in Differentiated Cells

B. Nadal-Ginard, T. Endo, 2022 .

Acute beta-adrenergic overload produces myocyte damage through calcium leakage from the ryanodine receptor 2 but spares cardiac stem cells.

A. Curcio, D. Goldspink, C. Indolfi, 2007, The Journal of biological chemistry.

Smooth muscle and brain inositol 1,4,5-trisphosphate receptors are structurally and functionally similar.

P. Tempst, A. Marks, B. Nadal-Ginard, 1990, The Journal of biological chemistry.

Cloning and characterization of cDNA sequences corresponding to myosin light chains 1, 2, and 3, troponin-C, troponin-T, alpha-tropomyosin, and alpha-actin.

B. Nadal-Ginard, M. Periasamy, L. Garfinkel, 1982, The Journal of biological chemistry.

Cardiovascular development: towards biomedical applicability

D. Torella, I. Karakikes, B. Nadal-Ginard, 2007, Cellular and Molecular Life Sciences.

Gene injection into canine myocardium as a useful model for studying gene expression in the heart of large mammals.

S. Vatner, B. Nadal-Ginard, R. von Harsdorf, 1993, Circulation research.

Rapid, two-stage arterial switch for transposition of the great arteries and intact ventricular septum beyond the neonatal period.

J. Mayer, R. Jonas, B. Nadal-Ginard, 1989, Circulation.

Monographic issue of pharmacological research on adult myocardial repair/regeneration.

D. Torella, B. Nadal-Ginard, A. De Angelis, 2018, Pharmacological research.

Small RNA molecules related to the Alu family of repetitive DNA sequences

L. Leinwand, B. Nadal-Ginard, R. Wydro, 1982, Molecular and cellular biology.

Cardiac ca- and 83-myosin heavy chain genes are organized in tandem

B. Nadal-Ginard, A. Chambers, Vuak Mahdavi, 2022 .

The adult heart responds to increased workload with physiologic hypertrophy, cardiac stem cell activation, and new myocyte formation

D. Goldspink, D. Torella, B. Nadal-Ginard, 2012, European heart journal.

Endogenous cardiac stem cell activation by insulin-like growth factor-1/hepatocyte growth factor intracoronary injection fosters survival and regeneration of the infarcted pig heart.

C. Indolfi, D. Torella, B. Nadal-Ginard, 2011, Journal of the American College of Cardiology.

Abstract 552: Biological Properties and Regenerative Potential, in vitro and in vivo, of Human Cardiac Stem Cells Isolated from Each of the Four Chambers of the Adult Human Heart

C. Indolfi, D. Torella, A. Renzulli, 2006 .

Angiotensin II induction of c-fos mRNA in cultured rat aortic smooth muscle cells is independent of stimulation of Na+/H+ exchange

B. Nadal-Ginard, B. Berk, S. Izumo, 1987 .

Scanning andCompetition between AGsAreInvolved in 3'Splice SiteSelection inMammalian Introns

B. Nadal-Ginard, T. T. Chu, Tung Tammy Chu, 1993 .

Response to Molkentin's letter to the editor regarding article, "the absence of evidence is not evidence of absence: the pitfalls of Cre knock-ins in the c-kit locus".

D. Torella, B. Nadal-Ginard, G. Ellison, 2014, Circulation research.

Characterization, and Long-Term Culture

B. Nadal-Ginard, D. Sassoon, F. Lewis, 2014 .

Locus Absence of Evidence Is Not Evidence of Absence: Pitfalls of Cre Knock-Ins in the c-Kit

D. Torella, B. Nadal-Ginard, G. Ellison, 2014 .

Bone marrow cell-induced protection of the human myocardium: characterization and mechanism of action.

B. Nadal-Ginard, M. Galiñanes, J. Linares-Palomino, 2009, The Journal of thoracic and cardiovascular surgery.

Rules for the diagnosis of visceral situs, truncoconal morphologies, and ventricular inversions.

B. Nadal-Ginard, M. de la Cruz, 1972, American heart journal.

Experimental study of the formation of the bulboventricular loop in the chick.

B. Nadal-Ginard, M. de la Cruz, A. Castro-Quezada, 1972, Journal of embryology and experimental morphology.

Cloning and character!zation of PSF, a novel pre-mRNA sphcing factor

J. G. Patton, B. Nadal-Ginard, J. Galcerán, 2007 .

Caffeine induces cardiac and other malformations in the rat.

H. Uno, H. Tanaka, B. Nadal-Ginard, 1987, American journal of medical genetics. Supplement.

Regulation of cyclins and p34CDC2 expression during terminal differentiation of C2C12 myocytes.

B. Nadal-Ginard, J. Wang, 1995, Biochemical and biophysical research communications.

Myocyte renewal and ventricular remodelling

P. Anversa, B. Nadal-Ginard, 2002, Nature.

Myocyte-Speciﬁc Enhancer Factor 2 and Thyroid Hormone Receptor Associate and Synergistically Activate the a -Cardiac Myosin Heavy-Chain Gene

Youngsook Lee, B. Nadal-Ginard, S. Izumo, 1997 .

Mammalian nonsarcomeric myosin regulatory light chains are encoded by two differentially regulated and linked genes [published erratum appears in J Cell Biol 1990 Nov;111(5 Pt 1):2207]

B. Nadal-Ginard, M. Taubman, J. Grant, 1990, The Journal of cell biology.

Cytoplasmic processing of myosin heavy chain messenger RNA: evidence provided by using a recombinant DNA plasmid.

B. Nadal-Ginard, H. Nguyen, R. Medford, 1980, Proceedings of the National Academy of Sciences of the United States of America.

The baby and the bath water: adult cardiac stem cells revisited.

D. Torella, B. Nadal-Ginard, E. Cianflone, 2021, European heart journal.

Vascular smooth muscle expresses a truncated Na+, K(+)-ATPase alpha-1 subunit isoform.

M. Ahmad, B. Nadal-Ginard, P. Allen, 1991, The Journal of biological chemistry.

Myocyte death, growth, and regeneration in cardiac hypertrophy and failure.

P. Anversa, A. Leri, B. Nadal-Ginard, 2003, Circulation research.

Gating mechanism of a cloned potassium channel expressed in frog oocytes and mammalian cells

B. Nadal-Ginard, E. Liman, D. Logothetis, 1990, Neuron.

Cardiac Stem Cell and Myocyte Aging, Heart Failure, and Insulin-Like Growth Factor-1 Overexpression

Mark A Sussman, D. Torella, M. Rota, 2004, Circulation research.

Bone Marrow Cells Differentiate in Cardiac Cell Lineages After Infarction Independently

C. Bearzi, M. Rota, A. Leri, 2004 .

Transient induction of poly(A)-short myosin heavy chain messenger RNA during terminal differentiation of L6E9 myoblasts.

B. Nadal-Ginard, S. Benoff, 1980, Journal of molecular biology.

Systematization and embryological and anatomical study of mirror-image dextrocardias, dextroversions, and laevoversions.

B. Nadal-Ginard, M. de la Cruz, G. Anselmi, 1971, British heart journal.

Transcriptional regulation of ribosomal RNA accumulation during L6E9 myoblast differentiation.

B. Nadal-Ginard, K. Krauter, R. Soeiro, 1979, Journal of molecular biology.

Sarcomeric myosin heavy chain gene family: organization and pattern of expression.

B. Nadal-Ginard, S. Izumo, E. Strehler, 1986, Medicine and science in sports and exercise.

Reversal of terminal differentiation and control of DNA replication: Cyclin A and cdk2 specifically localize at subnuclear sites of DNA replication

H. Leonhardt, M. C. Cardoso, B. Nadal-Ginard, 1993, Cell.

Acute β-Adrenergic Overload Produces Myocyte Damage through Calcium Leakage from the Ryanodine Receptor 2 but Spares Cardiac Stem Cells*

A. Curcio, D. Goldspink, C. Indolfi, 2007, Journal of Biological Chemistry.

Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications

V. Herrera, B. Nadal-Ginard, J. Emanuel, 1987, The Journal of cell biology.

Most myosin heavy chain mRNA in L6E9 rat myotubes has a short poly(A) tail.

B. Nadal-Ginard, S. Benoff, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Chimerism of the transplanted heart.

P. Anversa, A. Leri, C. Beltrami, 2002, The New England journal of medicine.

Adult cardiac stem cells are multipotent and robustly myogenic: c-kit expression is necessary but not sufficient for their identification

C. Indolfi, D. Torella, P. Veltri, 2017, Cell Death and Differentiation.

Adult c-kitpos Cardiac Stem Cells Are Necessary and Sufficient for Functional Cardiac Regeneration and Repair

Ciro Indolfi, Angelo Leone, Giuseppe Viglietto, 2013, Cell.

Type beta transforming growth factor is an inhibitor of myogenic differentiation.

J. Massagué, B. Nadal-Ginard, S. Cheifetz, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Molecular cloning and characterization of the ryanodine receptor/junctional channel complex cDNA from skeletal muscle sarcoplasmic reticulum.

P. Tempst, A. Marks, B. Nadal-Ginard, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Commitment, fusion and biochemical differentiation of a myogenic cell line in the absence of DNA synthesis

B. Nadal-Ginard, Bernardo Nadal-Ginard, 1978, Cell.

Reversibility of muscle differentiation in the absence of commitment: Analysis of a myogenic cell line temperature-sensitive for commitment

Hanh T. Nguyen, B. Nadal-Ginard, R. Medford, 1983, Cell.

Role of c-Kit in Myocardial Regeneration and Aging

D. Torella, B. Nadal-Ginard, E. Cianflone, 2019, Front. Endocrinol..

Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated.

B. Nadal-Ginard, V. Mahdavi, A. Lompré, 1984, The Journal of biological chemistry.

Moloney murine sarcoma proviral DNA is a transcriptional unit

B. Nadal-Ginard, E. Benz, R. Wydro, 1980, Nature.

Transcriptional and posttranscriptional control of c-myc during myogenesis: its mRNA remains inducible in differentiated cells and does not suppress the differentiated phenotype

B. Nadal-Ginard, T Endo, B Nadal-Ginard, 1986, Molecular and cellular biology.

Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation

Jay W. Schneider, Wei Gu, G. Condorelli, 1993, Cell.

Molecular basis of cardiac performance. Plasticity of the myocardium generated through protein isoform switches.

B. Nadal-Ginard, V. Mahdavi, Bernardo Nadal-Ginard, 1989, The Journal of clinical investigation.

All members of the MHC multigene family respond to thyroid hormone in a highly tissue-specific manner.

B. Nadal-Ginard, S. Izumo, V. Mahdavi, 1986, Science.

Generation of protein isoform diversity by alternative splicing: mechanistic and biological implications.

B. Nadal-Ginard, A. Andreadis, M. Gallego, 1987, Annual review of cell biology.

Complete nucleotide sequence of the fast skeletal troponin T gene. Alternatively spliced exons exhibit unusual interspecies divergence.

B. Nadal-Ginard, R. Breitbart, 1986, Journal of molecular biology.

Intricate combinatorial patterns of exon splicing generate multiple regulated troponin T isoforms from a single gene

Hanh T. Nguyen, B. Nadal-Ginard, R. Breitbart, 1985, Cell.

A novel mechanism of alternative RNA splicing for the developmentally regulated generation of troponin T isoforms from a single gene

Hanh T. Nguyen, B. Nadal-Ginard, R. Medford, 1984, Cell.

Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload.

B. Nadal-Ginard, S. Izumo, V. Mahdavi, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Alternative splicing is an efficient mechanism for the generation of protein diversity: contractile protein genes as a model system.

J. G. Patton, C. W. Smith, B. Nadal-Ginard, 1991, Advances in enzyme regulation.

Alternative Splicing: Mechanistic and Biological Implications of Generating Multiple Proteins from a Single Gene

B. Nadal-Ginard, A. Andreadis, M. Gallego, 1987 .

Developmental and hormonal regulation of sarcomeric myosin heavy chain gene family.

B. Nadal-Ginard, S. Izumo, V. Mahdavi, 1987, Circulation research.

Alpha-tropomyosin gene organization. Alternative splicing of duplicated isotype-specific exons accounts for the production of smooth and striated muscle isoforms.

B. Nadal-Ginard, N. Ruiz‐Opazo, 1987, The Journal of biological chemistry.

Mutually exclusive splicing of α-tropomyosin exons enforced by an unusual lariat branch point location: Implications for constitutive splicing

Christopher W. J. Smith, B. Nadal-Ginard, Bernardo Nadal-Ginard, 1989, Cell.

Muscle cell differentiation and alternative splicing.

B. Nadal-Ginard, 1990, Current opinion in cell biology.

Sustained Delivery of Insulin-Like Growth Factor-1/Hepatocyte Growth Factor Stimulates Endogenous Cardiac Repair in the Chronic Infarcted Pig Heart

Pieter A. Doevendans, Steven A. J. Chamuleau, Daniele Torella, 2014, Journal of Cardiovascular Translational Research.

Myocyte-specific enhancer factor 2 and thyroid hormone receptor associate and synergistically activate the alpha-cardiac myosin heavy-chain gene

B. Nadal-Ginard, S. Izumo, V. Mahdavi, 1997, Molecular and cellular biology.

Molecular cloning and sequence analysis of smooth muscle calponin.

B. Nadal-Ginard, K. Takahashi, 1991, The Journal of biological chemistry.

Cloning and characterization of PSF, a novel pre-mRNA splicing factor.

J. G. Patton, P. Tempst, J. Galceran, 1993, Genes & development.

Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death.

B. Safai, P. Anversa, A. Leri, 2001, Diabetes.

Oxidative Stress–Mediated Cardiac Cell Death Is a Major Determinant of Ventricular Dysfunction and Failure in Dog Dilated Cardiomyopathy

P. Anversa, A. Leri, L. Barlucchi, 2001, Circulation research.

Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing.

J. G. Patton, P. Tempst, B. Nadal-Ginard, 1991, Genes & development.

Complete nucleotide and encoded amino acid sequence of a mammalian myosin heavy chain gene. Evidence against intron-dependent evolution of the rod.

J C Perriard, B. Nadal-Ginard, J. Perriard, 1986, Journal of molecular biology.

Molecular characterization of two myosin heavy chain genes expressed in the adult heart

B. Nadal-Ginard, M. Periasamy, V. Mahdavi, 1982, Nature.

Molecular genetics of the SA-gene: cosegregation with hypertension and mapping to rat chromosome 1

D. Ganten, K. Lindpaintner, B. Nadal-Ginard, 1993, Journal of hypertension.

Disuse and passive stretch cause rapid alterations in expression of developmental and adult contractile protein genes in skeletal muscle.

G. Goldspink, B. Nadal-Ginard, S. Izumo, 1990, Development.

PROMOTER SELECTION AND ALTERNATIVE PRE-mRNA SPLICING ARE USED TO GENERATE COMPLEX CONTRACTILE PROTEIN PHENOTYPES

B. Nadal-Ginard, A. Andreadis, R. Breitbart, 1987 .

Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals.

R. Matsuoka, B. Nadal-Ginard, S. Izumo, 1987, The Journal of clinical investigation.

Scanning and competition between AGs are involved in 3' splice site selection in mammalian introns

Christopher W. J. Smith, C. W. Smith, B. Nadal-Ginard, 1993, Molecular and cellular biology.

Scanning from an independently specified branch point defines the 3′ splice site of mammalian introns

J. G. Patton, Christopher W. J. Smith, B. Nadal-Ginard, 1989, Nature.

Mapping and Use of a Sequence that Targets DNA Ligase I to Sites of DNA Replication In Vivo

H. Leonhardt, H. Rahn, M. C. Cardoso, 1997, The Journal of cell biology.

A muscle-specific enhancer is located at the 3' end of the myosin light-chain 1/3 gene locus.

N. Rosenthal, B. Wentworth, M. Donoghue, 1988, Genes & development.

Diabetes-Induced Cellular Senescence and Senescence-Associated Secretory Phenotype Impair Cardiac Regeneration and Function Independently of Age.

D. Torella, M. Rota, B. Nadal-Ginard, 2022, Diabetes.

Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells.

W. Gu, B. Nadal-Ginard, L. Zhu, 1994, Science.

Myocyte growth in the failing heart.

P. Anversa, A. Leri, B. Nadal-Ginard, 2004, The Surgical clinics of North America.

Telomerase expression and activity are coupled with myocyte proliferation and preservation of telomeric length in the failing heart

Z. Darżynkiewicz, P. Anversa, A. Leri, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Evidence that human cardiac myocytes divide after myocardial infarction.

P. Anversa, A. Leri, C. Beltrami, 2001, The New England journal of medicine.

Regulation of lactate dehydrogenase levels in the mouse.

B. Nadal-Ginard, 1978, The Journal of biological chemistry.

Alpha-tropomyosin mutually exclusive exon selection: competition between branchpoint/polypyrimidine tracts determines default exon choice.

J. G. Patton, C. W. Smith, B. Nadal-Ginard, 1991, Genes & development.

Slow myosin in developing rat skeletal muscle

M. Narusawa, B. Nadal-Ginard, S. Izumo, 1987, The Journal of cell biology.

The cardiac stem cell compartment is indispensable for myocardial cell homeostasis, repair and regeneration in the adult.

D. Torella, B. Nadal-Ginard, G. Ellison, 2014, Stem cell research.

Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy

Clotilde Castaldo, Daniele Torella, D. Torella, 2003, Proceedings of the National Academy of Sciences of the United States of America.

IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress.

P. Anversa, A. Leri, B. Nadal-Ginard, 2001, Diabetes.

Muscle is the major source of plasma gelsolin.

D. Kwiatkowski, B. Nadal-Ginard, S. Izumo, 1988, The Journal of biological chemistry.

A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage.

B. Nadal-Ginard, R. Breitbart, D. Laheru, 1993, Development.

Total dextroposition of the great vessels with obstruction of the left ventricular outlet.

B. Nadal-Ginard, J. Froufe, G. Sánz, 1973, Chest.

Smooth muscle‐specific switching of alpha‐tropomyosin mutually exclusive exon selection by specific inhibition of the strong default exon.

G. C. Roberts, C. Gooding, Christopher W. J. Smith, 1994, The EMBO journal.

Extrinsic factors in the genesis of congenital heart disease.

L. Muñoz-Castellanos, B. Nadal-Ginard, M. de la Cruz, 1971, British heart journal.

Co-expression of multiple myosin heavy chain genes, in addition to a tissue-specific one, in extraocular musculature

G. Butler-Browne, B. Nadal-Ginard, M. Periasamy, 1985, The Journal of cell biology.

Characterization of cDNA and genomic sequences corresponding to an embryonic myosin heavy chain.

B. Nadal-Ginard, E. Strehler, M. Periasamy, 1985, The Journal of biological chemistry.

Cell-free translation of mammalian myosin heavy-chain messenger ribonucleic acid from growing and fused-L6E9 myoblasts.

B. Nadal-Ginard, S. Benoff, 1979, Biochemistry.

Transcriptional and cell cycle-mediated regulation of myosin heavy chain gene expression during muscle cell differentiation.

B. Nadal-Ginard, H. Nguyen, R. Medford, 1983, The Journal of biological chemistry.

Angiotensin II induces c-fos mRNA in aortic smooth muscle. Role of Ca2+ mobilization and protein kinase C activation.

R. Alexander, B. Nadal-Ginard, B. Berk, 1989, The Journal of biological chemistry.

In vitro CSC-derived cardiomyocytes exhibit the typical microRNA-mRNA blueprint of endogenous cardiomyocytes

D. Torella, P. Veltri, A. Weisz, 2021, Communications Biology.

Adult c-kit(pos) cardiac stem cells fulfill Koch's postulates as causal agents for cardiac regeneration.

Daniele Torella, D. Torella, B. Nadal-Ginard, 2014, Circulation research.

Stem Cells and Heart Disease

P. Anversa, A. Leri, B. Nadal-Ginard, 2014 .

Chapter 54 – Stem Cells and Heart Disease

P. Anversa, A. Leri, B. Nadal-Ginard, 2013 .

Co-expression of Multiple Myosin Heavy In Addition to a Tissue-Specific One , in Extraocular Musculature Chain Genes ,

G. Butler-Browne, B. Nadal-Ginard, M. Periasamy, 2003 .

Complete amino acid sequence of canine cardiac calsequestrin deduced by cDNA cloning.

J. H. Collins, Simmerman, B. Nadal-Ginard, 1988, The Journal of biological chemistry.

Cardiac adaptations from 4 weeks of intensity-controlled vigorous exercise are lost after a similar period of detraining

D. Torella, B. Nadal-Ginard, Cheryl D. Waring, 2015, Physiological reports.

Inhibition of muscle differentiation by trypanosoma cruzi.

B. Nadal-Ginard, H. Tanowitz, H. Nguyen, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Cloning and characterization of an olfactory cyclic nucleotide-gated channel expressed in mouse heart.

M. L. Ruiz, B. Nadal-Ginard, B. London, 1996, Journal of molecular and cellular cardiology.

Cloning phospholamban cDNA from rat aortic smooth muscle.

B. Nadal-Ginard, K. Hwang, 1991, Advances in experimental medicine and biology.

[Cardiovascular regenerative medicine at the crossroads. Clinical trials of cellular therapy must now be based on reliable experimental data from animals with characteristics similar to human's].

D. Torella, B. Nadal-Ginard, G. Ellison, 2006, Revista espanola de cardiologia.

Cardiac stem cells and myocardial regeneration.

P. Anversa, A. Leri, B. Nadal-Ginard, 2006 .

Adult Cardiac Stem Cells: Identity, Location and Potential

D. Torella, B. Nadal-Ginard, F. Lewis, 2014 .

Optimizing Cardiac Repair and Regeneration Through Activation of the Endogenous Cardiac Stem Cell Compartment

D. Torella, B. Nadal-Ginard, G. Ellison, 2012, Journal of Cardiovascular Translational Research.

Growth-factor-mediated cardiac stem cell activation in myocardial regeneration

D. Torella, I. Karakikes, B. Nadal-Ginard, 2007, Nature Clinical Practice Cardiovascular Medicine.

Resident progenitors and bone marrow stem cells in myocardial renewal and repair

D. Torella, B. Nadal-Ginard, S. Méndez-Ferrer, 2006, Nature Clinical Practice Cardiovascular Medicine.

Resident human cardiac stem cells: role in cardiac cellular homeostasis and potential for myocardial regeneration

D. Torella, B. Ibáñez, B. Nadal-Ginard, 2006, Nature Clinical Practice Cardiovascular Medicine.

Primitive Cells and Tissue Regeneration

P. Anversa, A. Leri, B. Nadal-Ginard, 2003, Circulation research.

Nadal-Ginard et al Myocyte Death and Growth in the Diseased Heart

P. Anversa, A. Leri, B. Nadal-Ginard, 2003 .

Myocyte growth and cardiac repair.

P. Anversa, A. Leri, B. Nadal-Ginard, 2002, Journal of molecular and cellular cardiology.

Functional and Physical Interactions between Mammalian Achaete-Scute Homolog 1 and Myocyte Enhancer Factor 2A*

B. Nadal-Ginard, Z. Mao, Zixu Mao, 1996, The Journal of Biological Chemistry.

Identification of a cis-acting regulatory element conferring inducibility of the atrial natriuretic factor gene in acute pressure overload.

L. Leinwand, S. Vatner, R. Dietz, 1997, The Journal of clinical investigation.

H. Schunkert, B. Nadal-Ginard, S. Izumo, 1992, The Journal of clinical investigation.

Heterogeneity of Adult Cardiac Stem Cells.

D. Torella, B. Nadal-Ginard, E. Cianflone, 2019, Advances in experimental medicine and biology.

Clox, a mammalian homeobox gene related to Drosophila cut, encodes DNA-binding regulatory proteins differentially expressed during development.

B. Nadal-Ginard, V. Mahdavi, V. Andrés, 1992, Development.

Evidence for the lack of feedback regulation of gene activity and for the absence of subunit exchange between lactate dehydrogenase tetramers in vivo.

B. Nadal-Ginard, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Unco-ordinate regulation of ribosomal RNA and ribosomal protein synthesis during L6E9 myoblast differentiation.

B. Nadal-Ginard, K. Krauter, R. Soeiro, 1980, Journal of molecular biology.

The Upper Limb-Cardiovascular Syndrome (Holt-Oram Syndrome)

B. Nadal-Ginard, L. Buentello, L. Mata, 1973 .

The upper limb-cardiovascular syndrome (Holt-Oram syndrome). A survey and a report of four cases.

B. Nadal-Ginard, L. Buentello, L. Mata, 1973, Clinical pediatrics.

Intron positions are conserved in the 5' end region of myosin heavy-chain genes.

B. Nadal-Ginard, E. Strehler, M. Periasamy, 1985, The Journal of biological chemistry.

Molecular mechanisms of cardiac gene expression.

B. Nadal-Ginard, V. Mahdavi, 1993, Basic research in cardiology.

Incremental reductions of positive charge within the S4 region of a voltage-gated K+ channel result in corresponding decreases in gating charge

K. Lindpaintner, B. Nadal-Ginard, D. Logothetis, 1992, Neuron.

Prinzmetal's angina with recurrent and transitory atrio-ventricular block.

M. Cárdenas, B. Nadal-Ginard, 1973, Acta cardiologica.

c-kit Haploinsufficiency impairs adult cardiac stem cell growth, myogenicity and myocardial regeneration

G. Viglietto, D. Torella, B. Nadal-Ginard, 2019, Cell Death & Disease.

Identification of a high molecular weight presumptive precursor to albumin mRNA in the nucleus of rat liver and hepatoma cell line H4AZC2.

B. Nadal-Ginard, D. Shafritz, S. Yap, 1978, The Journal of biological chemistry.

Some like it plastic.

P. Anversa, A. Leri, B. Nadal-Ginard, 2004, Circulation research.

Gating charge differences between two voltagegated K+ channels are due to the specific charge content of their respective S4 regions

K. Lindpaintner, B. Nadal-Ginard, D. Logothetis, 1993, Neuron.

C-kit + CSC-derived cardiomyocytes exhibit the typical transcriptional gene blueprint of adult cardiomyocytes

C. Indolfi, D. Torella, P. Veltri, 2015 .

Basic mechanisms of cardiac gene expression.

B. Nadal-Ginard, V. Mahdavi, 1993, European heart journal.

Abstract 19155: Cardiac Stem Cell Activation and Ensuing Myogenesis and Angiogenesis Contribute to Cardiac Adaptation following Intensity-Controlled Exercise Training

D. Goldspink, D. Torella, B. Nadal-Ginard, 2010 .

Cardiac myocyte terminal differentiation. Potential for cardiac regeneration.

W. Gu, B. Nadal-Ginard, V. Mahdavi, 1995, Annals of the New York Academy of Sciences.

Sarcomeric myosin heavy chain is coded by a highly conserved multigene family.

B. Nadal-Ginard, H. Nguyen, R. Gubits, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Myocardial cell therapy at the crossroads

V. Fuster, B. Nadal-Ginard, 2007, Nature Clinical Practice Cardiovascular Medicine.

Chimera or not chimera?

P. Anversa, B. Nadal-Ginard, 2002, Circulation research.

Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors.

B. Nadal-Ginard, R. Breitbart, L. Smoot, 1992, Genes & development.

MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex.

S. Lipton, J. McDermott, B. Kosofsky, 1993, Proceedings of the National Academy of Sciences of the United States of America.

The morphologic expression of each cardiac primordium in the chick embryo.

B. Nadal-Ginard, B Nadal-Ginard, M P García, 1972, Journal of embryology and experimental morphology.

Cardiac stem cells and myocardial regeneration.

P. Anversa, A. Leri, B. Nadal-Ginard, 2005, Novartis Foundation symposium.

E2F1 inhibition of transcription activation by myogenic basic helix‐loop‐helix regulators

B. Nadal-Ginard, Wei-ning Tang, Jian Wang, 1996, Journal of cellular biochemistry.

c-kit Haploinsufficiency impairs adult cardiac stem cell growth, myogenicity and myocardial regeneration

G. Viglietto, D. Torella, B. Nadal-Ginard, 2019, Cell Death & Disease.

Absence of evidence is not evidence of absence: pitfalls of cre knock-ins in the c-Kit locus.

D. Torella, B. Nadal-Ginard, G. Ellison, 2014, Circulation research.

Purification, characterization, and molecular cloning of a 60-kDa phosphoprotein in rabbit skeletal sarcoplasmic reticulum which is an isoform of phosphoglucomutase.

Y. S. Lee, A. Marks, B. Nadal-Ginard, 1992, The Journal of biological chemistry.

[Cardiovascular regenerative medicine at the crossroads. Clinical trials of cellular therapy must now be based on reliable experimental data from animals with characteristics similar to human's].

D. Torella, B. Nadal-Ginard, G. Ellison, 2006, Revista espanola de cardiologia.

Characterization of wild type and mutant chicken gizzard α calponin expressed in E. coli

B. Nadal-Ginard, T. Tao, K. Mabuchi, 1993 .

Comparison of alpha-tropomyosin sequences from smooth and striated muscle.

B. Nadal-Ginard, N. Ruiz‐Opazo, J. Weinberger, 1985, Nature.