K. Kleopa

发表

Genetic mechanisms of peripheral nerve disease

M. Stavrou, I. Sargiannidou, Theodoulakis Christofi, 2020, Neuroscience Letters.

Gene Therapy for CMT Inherited Neuropathy

I. Sargiannidou, K. Kleopa, A. Kagiava, 2019, Muscle Gene Therapy.

Inherited neuropathies.

S. Scherer, K. Kleopa, 2002, Neurologic clinics.

KCNQ2 Is a Nodal K+ Channel

S. Scherer, K. Kleopa, J. Devaux, 2004, The Journal of Neuroscience.

Bipap improves survival and rate of pulmonary function decline in patients with ALS

K. Kleopa, T. Heiman-Patterson, M. Sherman, 1999, Journal of the Neurological Sciences.

Retrospective longitudinal study of ALS in Cyprus: Clinical characteristics, management and survival

C. Demetriou, K. Kleopa, Petros M Hadjivasiliou, 2019, PloS one.

A quantitative method for the assessment of dysarthrophonia in myasthenia gravis

K. Kleopa, P. Vogazianos, Y. Christou, 2017, Journal of the Neurological Sciences.

Autoimmune Channelopathies and Related Neurological Disorders

A. Vincent, K. Kleopa, B. Lang, 2006, Neuron.

Human oligodendrocytes express Cx31.3: Function and interactions with Cx32 mutants

R. Reynolds, A. Peinado, S. Scherer, 2008, Neurobiology of Disease.

Hereditary Spastic Paraplegia

K. Kleopa, 2005 .

Inherited Neuropathies: Clinical, Genetic, and Biological Features

S. Scherer, K. Kleopa, L. Wrabetz, 2004 .

Maximal voluntary ventilation in myasthenia gravis

K. Kleopa, I. Heliopoulos, H. Piperidou, 2003, Muscle & nerve.

Prevalence of Anti-JC Virus (JCV) Antibodies in the Multiple Sclerosis (MS) Population in Cyprus: A Retrospective Study

C. Demetriou, K. Kleopa, S. Papacostas, 2019, Neurology research international.

Connexin43 and connexin47 alterations after neural precursor cells transplantation in experimental autoimmune encephalomyelitis

K. Kleopa, E. Dardiotis, G. Hadjigeorgiou, 2015, Glia.

A start codon CMT1X mutation associated with transient encephalomyelitis causes complete loss of Cx32

I. Sargiannidou, K. Kleopa, Gun-Ha Kim, 2015, neurogenetics.

Diverse Trafficking Abnormalities of Connexin32 Mutants Causing CMTX

S. Scherer, K. Kleopa, S. Shumas, 2002, Neurobiology of Disease.

Alterations of juxtaparanodal domains in two rodent models of CNS demyelination

K. Kleopa, D. Karagogeos, K. Markoullis, 2013, Glia.

Loss of Coupling Distinguishes GJB1 Mutations Associated with CNS Manifestations of CMT1X from Those Without CNS Manifestations

Sarah Wong, A. Peinado, M. Goman, 2017, Scientific Reports.

Adenosine A1 receptors in human hippocampus: inhibition of [3H]8-cyclopentyl-1,3-dipropylxanthine binding by antagonist drugs

S. Heckers, H. Heinsen, P. Riederer, 1993, Neuroscience Letters.

Dysregulation of Blood-Brain Barrier and Exacerbated Inflammatory Response in Cx47-Deficient Mice after Induction of EAE

I. Sargiannidou, K. Kleopa, Filippos Stavropoulos, 2021, Pharmaceuticals.

Connexin32 Mutations Cause Loss of Function in Schwann Cells and Oligodendrocytes Leading to PNS and CNS Myelination Defects

K. Kyriacou, A. Hadjisavvas, S. Scherer, 2009, The Journal of Neuroscience.

Differential modulation of the juxtaparanodal complex in Multiple Sclerosis

I. Sargiannidou, K. Kleopa, D. Karagogeos, 2015, Molecular and Cellular Neuroscience.

Mutation of a putative protein degradation gene LITAF/SIMPLE in Charcot-Marie-Tooth disease 1C

J. Goldy, T. Bird, S. Scherer, 2003, Neurology.

Emerging Therapies for Charcot-Marie-Tooth Inherited Neuropathies

M. Stavrou, I. Sargiannidou, K. Kleopa, 2021, International journal of molecular sciences.

Gene delivery targeted to oligodendrocytes using a lentiviral vector

A. Gritti, I. Sargiannidou, K. Kleopa, 2014, The journal of gene medicine.

Molecular genetics of X-linked Charcot-Marie-Tooth disease

S. Scherer, K. Kleopa, 2006 .

Carpal Tunnel Syndrome

K. Kleopa, 2015, Annals of Internal Medicine.

X‐linked Charcot‐Marie‐Tooth disease

S. Scherer, K. Kleopa, 2012, Journal of the peripheral nervous system : JPNS.

Morvan syndrome: Clinical and serological observations in 29 cases

A. Vincent, K. Kleopa, S. Irani, 2012, Annals of neurology.

A novel PMP22 mutation Ser22Phe in a family with hereditary neuropathy with liability to pressure palsies and CMT1A phenotypes

K. Kleopa, K. Christodoulou, E. Papathanasiou, 2004, Neurogenetics.

Epidemiology of Amyotrophic Lateral Sclerosis in the Republic of Cyprus: A 25-Year Retrospective Study

C. Demetriou, K. Kleopa, Petros M Hadjivasiliou, 2017, Neuroepidemiology.

Morvan's syndrome associated with antibodies to multiple components of the voltage-gated potassium channel complex

K. Kleopa, A. Vincent, P. Pettingill, 2012, Journal of the Neurological Sciences.

Gene therapy approaches targeting Schwann cells for demyelinating neuropathies

I. Sargiannidou, K. Kleopa, A. Kagiava, 2019, Brain Research.

Naturally occurring utrophin correlates with disease severity in Duchenne muscular dystrophy.

A. Drousiotou, K. Kleopa, T. Kyriakides, 2006, Human molecular genetics.

Disruption of oligodendrocyte gap junctions in experimental autoimmune encephalomyelitis

R. Reynolds, A. Hadjisavvas, I. Sargiannidou, 2012, Glia.

A retrospective observational study of rituximab treatment in multiple sclerosis patients in Cyprus

M. Loizidou, K. Kleopa, Y. Christou, 2019, Postgraduate medicine.

Regulatory role of oligodendrocyte gap junctions in inflammatory demyelination

I. Sargiannidou, K. Kleopa, C. Karaiskos, 2018, Glia.

Malignant hyperthermia-like episode in Becker muscular dystrophy.

K. Kleopa, T. Heiman-Patterson, H. Rosenberg, 2000, Anesthesiology.

Severe Neurological Impairment in an Infant after Nitrous Oxide Anesthesia

K. Kleopa, T. Heiman-Patterson, H. Rosenberg, 2000 .

How do mutations in GJB1 cause X-linked Charcot–Marie–Tooth disease?

S. Scherer, K. Kleopa, C. Abrams, 2012, Brain Research.

Acute axonal neuropathy in maple syrup urine disease

D. Raizen, K. Kleopa, Mark J. Brown, 2001, Muscle & nerve.

Intrathecal gene therapy in mouse models expressing CMT1X mutations

I. Sargiannidou, K. Kleopa, A. Kagiava, 2018, Human molecular genetics.

Systemic inflammation disrupts oligodendrocyte gap junctions and induces ER stress in a model of CNS manifestations of X-linked Charcot-Marie-Tooth disease

I. Sargiannidou, K. Kleopa, A. Kagiava, 2016, Acta neuropathologica communications.

Connexins, gap junctions and peripheral neuropathy

I. Sargiannidou, K. Kleopa, 2015, Neuroscience Letters.

Molecular genetics of X-linked Charcot-Marie-Tooth disease

S. Scherer, K. Kleopa, 2007, NeuroMolecular Medicine.

Phenotypic and cellular expression of two novel connexin32 mutations causing CMT1X

A. Hadjisavvas, K. Kleopa, T. Kyriakides, 2006, Neurology.

Hereditary spastic paraplegia linked to chromosome 14q11-q21: reduction of the SPG3 locus interval from 5.3 to 2.7 cM

P. Hedera, K. Kleopa, J. Fink, 2001, Journal of medical genetics.

Multifocal motor neuropathy with conduction block associated with metastatic lymphoma of the nervous system

K. Kleopa, F. Hochberg, J. Baehring, 2006, Journal of Neuro-Oncology.

Peripheral neuropathies

M. Benson, S. Scherer, K. Kleopa, 2020, Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease.

Gene replacement therapy in a model of Charcot-Marie-Tooth 4C neuropathy

H. Zetterberg, I. Sargiannidou, K. Kleopa, 2019, Brain : a journal of neurology.

Open-Label Fosmetpantotenate, a Phosphopantothenate Replacement Therapy in a Single Patient with Atypical PKAN

H. Plotkin, K. Kleopa, M. Beconi, 2017, Case reports in neurological medicine.

AAV9-mediated Schwann cell-targeted gene therapy rescues a model of demyelinating neuropathy

H. Zetterberg, R. Horvath, M. Stavrou, 2021, Gene Therapy.

Novel homozygous PANK2 mutation causing atypical pantothenate kinase-associated neurodegeneration (PKAN) in a Cypriot family

K. Kleopa, G. Tanteles, E. Spanou-Aristidou, 2014, Journal of the Neurological Sciences.

Primary T-cell lymphoma of the cerebellum

H. Reichmann, K. Kleopa, W. Roggendorf, 1996, Journal of Neuro-Oncology.

Unique distributions of the gap junction proteins connexin29, connexin32, and connexin47 in oligodendrocytes

D. Paul, S. Scherer, K. Kleopa, 2004, Glia.

Aberrant Mitochondrial Dynamics and Exacerbated Response to Neuroinflammation in a Novel Mouse Model of CMT2A

I. Sargiannidou, K. Kleopa, A. Kagiava, 2021, International journal of molecular sciences.

Connexin29 Is Uniquely Distributed within Myelinating Glial Cells of the Central and Peripheral Nervous Systems

Bruce M Altevogt, B. Altevogt, D. Paul, 2002, The Journal of Neuroscience.

Golgi‐retained Cx32 mutants interfere with gene addition therapy for CMT1X

I. Sargiannidou, K. Kleopa, A. Kagiava, 2017, Human molecular genetics.

Gene replacement therapy after neuropathy onset provides therapeutic benefit in a model of CMT1X.

H. Zetterberg, I. Sargiannidou, K. Kleopa, 2019, Human molecular genetics.

Gap junction pathology in multiple sclerosis lesions and normal-appearing white matter

R. Reynolds, A. Hadjisavvas, I. Sargiannidou, 2012, Acta Neuropathologica.

Novel GJA1/Cx43 Variant Associated With Oculo-Dento-Digital Dysplasia Syndrome: Clinical Phenotype and Cellular Mechanisms

A. Hadjisavvas, I. Sargiannidou, K. Kleopa, 2021, Frontiers in Genetics.

NCAM1 and GDF15 are biomarkers of Charcot-Marie-Tooth disease in patients and mice

R. Burgess, C. Borchers, H. Lochmüller, 2022, Brain : a journal of neurology.

Intrathecal Delivery of Viral Vectors for Gene Therapy.

K. Kleopa, A. Kagiava, 2018, Methods in molecular biology.

Intrathecal gene therapy rescues a model of demyelinating peripheral neuropathy

G. Theophilidis, S. Scherer, I. Sargiannidou, 2016, Proceedings of the National Academy of Sciences.

Acute cervical radiculopathies in spontaneous intracranial hypotension

K. Kleopa, K. Natsiopoulos, 2009, Journal of Neurology.

Acute cervical radiculop- athies in spontaneous intracranial hypotension

K. Kleopa, K. Natsiopoulos, 2009 .

Glial Gap Junction Pathology in the Spinal Cord of the 5xFAD Mouse Model of Early-Onset Alzheimer’s Disease

Andreas M. Koupparis, I. Sargiannidou, K. Kleopa, 2022, International journal of molecular sciences.

Autoimmune Channelopathies of the Nervous System

K. Kleopa, 2011, Current neuropharmacology.

Impairment of learning and memory in TAG-1 deficient mice associated with shorter CNS internodes and disrupted juxtaparanodes

T. Panagiotaropoulos, I. Sargiannidou, K. Kleopa, 2008, Molecular and Cellular Neuroscience.

Neuromyotonia and limbic encephalitis sera target mature Shaker-type K+ channels: subunit specificity correlates with clinical manifestations.

A. Vincent, S. Scherer, K. Kleopa, 2006, Brain : a journal of neurology.

Molecular KCNQ 2 Is a Nodal K Channel

Steven S. Scherer, Edward C. Cooper, S. Scherer, 2004 .

The phenotypic spectrum of pathogenic ATP1A1 variants expands: the novel p.P600R substitution causes demyelinating Charcot–Marie–Tooth disease

S. Züchner, A. Rebelo, K. Kleopa, 2023, Journal of Neurology.

Chapter 88 – Peripheral Neuropathies

M. Benson, S. Scherer, K. Kleopa, 2015 .

Evolution of GLUD2 Glutamate Dehydrogenase Allows Expression in Human Cortical Neurons

K. Kleopa, A. Plaitakis, C. Spanaki, 2016, Molecular Neurobiology.

Genetic disorders of neuromuscular ion channels

K. Kleopa, R. Barchi, 2002, Muscle & nerve.

Connexin pathology in chronic multiple sclerosis and experimental autoimmune encephalomyelitis

I. Sargiannidou, K. Kleopa, K. Markoullis, 2013 .

Titin antibodies in “seronegative” myasthenia gravis — A new role for an old antigen

N. Gilhus, K. Kleopa, R. Mantegazza, 2016, Journal of Neuroimmunology.

Investigation of SCA10 in the Cypriot population: Further exclusion of SCA dynamic repeat mutations

K. Kleopa, K. Christodoulou, S. Papacostas, 2012, Journal of the Neurological Sciences.

Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan’s syndrome and acquired neuromyotonia

A. Vincent, E. Peles, K. Kleopa, 2010, Brain : a journal of neurology.

Novel GLI3 mutation in a Greek–Cypriot patient with Greig cephalopolysyndactyly syndrome

K. Kleopa, G. Tanteles, Eleni Loukianou, 2015, Clinical dysmorphology.

Myasthenia gravis genome-wide association study implicates AGRN as a risk locus

J. Stamatoyannopoulos, P. Paschou, E. Maltezos, 2021, Journal of Medical Genetics.

Compressive lumbar myelopathy presenting as segmental motor neuron disease

K. Kleopa, T. Kyriakides, E. Zamba-Papanicolaou, 2003, Muscle & nerve.

A comprehensive analysis of the epidemiology and clinical characteristics of anti-LRP4 in myasthenia gravis.

K. Kleopa, T. Stojkovic, R. Mantegazza, 2014, Journal of autoimmunity.

The Role of Gap Junctions in Charcot-Marie-Tooth Disease

K. Kleopa, Kleopas A Kleopa, 2011, The Journal of Neuroscience.

Human GLUD2 Glutamate Dehydrogenase Is Expressed in Neural and Testicular Supporting Cells*

K. Kleopa, A. Plaitakis, I. Zaganas, 2010, The Journal of Biological Chemistry.

Charcot–Marie–Tooth Disease

K. Kleopa, 2013 .

Reversible inflammatory and vacuolar myopathy with vitamin E deficiency in celiac disease

K. Kyriacou, K. Kleopa, T. Kyriakides, 2005, Muscle & nerve.

Cellular mechanisms of connexin32 mutations associated with CNS manifestations

S. Scherer, K. Kleopa, S. Yum, 2002, Journal of neuroscience research.

Molecular mechanisms of gap junction mutations in myelinating cells.

I. Sargiannidou, K. Kleopa, K. Markoullis, 2010, Histology and histopathology.

Gap Junction Disorders of Myelinating Cells

I. Sargiannidou, K. Kleopa, Jennifer L. Orthmann-Murphy, 2010, Reviews in the neurosciences.

Oligodendrocyte Gap Junction Loss and Disconnection From Reactive Astrocytes in Multiple Sclerosis Gray Matter

R. Reynolds, I. Sargiannidou, K. Kleopa, 2014, Journal of neuropathology and experimental neurology.

MuSK autoantibodies in myasthenia gravis detected by cell based assay — A multinational study

K. Kleopa, R. Mantegazza, T. Sharshar, 2015, Journal of Neuroimmunology.

Autoimmune limbic encephalitis in 39 patients: immunophenotypes and outcomes

Gregory F. Wu, M. Rosenfeld, J. Dalmau, 2006, Journal of Neurology, Neurosurgery & Psychiatry.

The role of oligodendrocyte gap junctions in neuroinflammation

K. Kleopa, C. Papaneophytou, E. Georgiou, 2019, Channels.

Chronic multiple paraneoplastic syndromes

S. Galetta, S. Scherer, K. Kleopa, 2000, Muscle & nerve.

Altered Expression of Glial Gap Junction Proteins Cx43, Cx30, and Cx47 in the 5XFAD Model of Alzheimer’s Disease

I. Sargiannidou, K. Kleopa, S. Papacostas, 2020, Frontiers in Neuroscience.

Genetic and Environmental Factors Contributing to Parkinson's Disease: A Case-Control Study in the Cypriot Population

C. Demetriou, M. Pantziaris, M. Loizidou, 2019, Front. Neurol..

Gene therapy targeting oligodendrocytes provides therapeutic benefit in a leukodystrophy model

M. Klugmann, I. Sargiannidou, K. Kleopa, 2017, Brain : a journal of neurology.

Ulnar neuropathy at Guyon's canal: electrophysiological and surgical findings.

K. Kleopa, S. Papacostas, E. Papathanasiou, 2005, Electromyography and clinical neurophysiology.

CMT1A current gene therapy approaches and promising biomarkers

K. Kleopa, Marina Stavrou, 2022, Neural regeneration research.

Robotic device for transcranial focussed ultrasound applications in small animal models

C. Damianou, K. Kleopa, M. Giannakou, 2022, The international journal of medical robotics + computer assisted surgery : MRCAS.

Efficacy of AAV serotypes to target Schwann cells after intrathecal and intravenous delivery

I. Sargiannidou, K. Kleopa, A. Kagiava, 2021, Scientific Reports.

A translatable RNAi-driven gene therapy silences PMP22/Pmp22 genes and improves neuropathy in CMT1A mice

S. Harper, H. Zetterberg, R. Horvath, 2022, The Journal of clinical investigation.

Intraneural GJB1 gene delivery improves nerve pathology in a model of X‐linked Charcot–Marie–Tooth disease

S. Scherer, I. Sargiannidou, K. Kleopa, 2015, Annals of neurology.

Axonal Pathology Precedes Demyelination in a Mouse Model of X-Linked Demyelinating/Type I Charcot-Marie Tooth Neuropathy

K. Kyriacou, S. Scherer, I. Sargiannidou, 2010, Journal of neuropathology and experimental neurology.

Systemic inflammation disrupts oligodendrocyte gap junctions and induces ER stress in a model of CNS manifestations of X-linked Charcot-Marie-Tooth disease

I. Sargiannidou, K. Kleopa, A. Kagiava, 2016, Acta neuropathologica communications.

A novel ALS2 splice-site mutation in a Cypriot juvenile-onset primary lateral sclerosis family

K. Kleopa, K. Christodoulou, E. Zamba-Papanicolaou, 2009, Neurology.

Charcot–Marie–Tooth neuropathies: Current gene therapy advances and the route toward translation

I. Sargiannidou, K. Kleopa, A. Kagiava, 2023, Journal of the peripheral nervous system : JPNS.

Oxaliplatin-induced neurotoxicity is mediated through gap junction channels and hemichannels and can be prevented by octanol

K. Kyriacou, G. Theophilidis, I. Sargiannidou, 2015, Neuropharmacology.

Transgenic replacement of Cx32 in gap junction-deficient oligodendrocytes rescues the phenotype of a hypomyelinating leukodystrophy model.

I. Sargiannidou, K. Kleopa, A. Kagiava, 2015, Human molecular genetics.

Charcot-Marie-Tooth Disease in Cyprus: Epidemiological, Clinical and Genetic Characteristics

K. Kleopa, G. Hadjigeorgiou, A. Papadimitriou, 2010, Neuroepidemiology.

A novel movement disorder of the lower lip

K. Kleopa, T. Kyriakides, 2004, Movement disorders : official journal of the Movement Disorder Society.

Antibodies to Components of the Voltage-Gated Potassium Channel - Associated Complex: LGI1 and CASPR2 as Antigenic Targets in Limbic Encephalitis, Morvan's and Neuromyotonia

A. Vincent, K. Kleopa, S. Irani, 2010 .

Transient, Recurrent Central Nervous System Clinical Manifestations of X-Linked Charcot-Marie-Tooth Disease Presenting with Very Long Latency Periods between Episodes: Is Prolonged Sun Exposure a Provoking Factor?

K. Kleopa, C. Michaelides, Andria Tziakouri, 2020, Case reports in neurological medicine.

A start codon CMT1X mutation associated with transient encephalomyelitis causes complete loss of Cx32

I. Sargiannidou, K. Kleopa, Gun-Ha Kim, 2015, neurogenetics.

A Myasthenia Gravis genomewide association study of three cohorts identifies Agrin as a novel risk locus.

J. Stamatoyannopoulos, P. Paschou, E. Maltezos, 2020, medRxiv.

Variant transthyretin amyloidosis (ATTRv) polyneuropathy in Greece: a broad overview with a focus on non-endemic unexplored regions of the country

M. Dimopoulos, E. Oikonomou, K. Kleopa, 2021, Neuromuscular Disorders.

FUS-mediated blood–brain barrier disruption for delivering anti-Aβ antibodies in 5XFAD Alzheimer’s disease mice

C. Damianou, K. Kleopa, S. Papacostas, 2023, Journal of ultrasound.

Vestibular symptoms and signs are correlated with abnormal neurogenic vestibular evoked potentials in patients with multiple sclerosis.

K. Kleopa, S. Papacostas, E. Papathanasiou, 2005, Electromyography and clinical neurophysiology.

Gene replacement therapy in two Golgi-retained CMT1X mutants before and after the onset of demyelinating neuropathy

I. Sargiannidou, K. Kleopa, A. Kagiava, 2023, Molecular therapy. Methods & clinical development.

Mitofusin 1 overexpression rescues the abnormal mitochondrial dynamics caused by the Mitofusin 2 K357T mutation in vitro

I. Sargiannidou, K. Kleopa, R. Baloh, 2023, Journal of the peripheral nervous system.

Peripheral neuropathies

M. Benson, S. Scherer, K. Kleopa, 2020, Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease.

Impact of Vutrisiran on Quality of Life and Physical Function in Patients with Hereditary Transthyretin-Mediated Amyloidosis with Polyneuropathy

Karla P. Zepeda, Hansie M Mathelier, J. Felius, 2023, Neurology and Therapy.

PheWAS and cross-disorder analysis reveal genetic architecture, pleiotropic loci and phenotypic correlations across 11 autoimmune disorders

P. Paschou, K. Kleopa, E. Zamba-Papanicolaou, 2023, Frontiers in immunology.

Gene replacement therapy in a model of Charcot-Marie-Tooth 4C neuropathy

H. Zetterberg, I. Sargiannidou, K. Kleopa, 2019, Brain : a journal of neurology.

Glial Cells as Key Regulators in Neuroinflammatory Mechanisms Associated with Multiple Sclerosis

I. Sargiannidou, K. Kleopa, Styliani Theophanous, 2024, International journal of molecular sciences.

Evolution of GLUD2 Glutamate Dehydrogenase Allows Expression in Human Cortical Neurons

K. Kleopa, A. Plaitakis, C. Spanaki, 2015, Molecular Neurobiology.

Lumbar Intrathecal Injection in Adult and Neonatal Mice

K. Kleopa, E. Georgiou, Marina Stavrou, 2024, Current protocols.