B. Poppe

R. Vanholder, K. Claes, B. Maes, 2007, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Shortcutting the diagnostic odyssey: the multidisciplinary Program for Undiagnosed Rare Diseases in adults (UD-PrOZA)

P. Verloo, P. Boon, B. Poppe, 2022, Orphanet Journal of Rare Diseases.

Slow progression of chronic renal failure in a woman of short stature and leg deformities: what is the link?

B. Maes, B. Poppe, A. Vanacker, 2008, NDT plus.

Direct-to-consumer genetic testing services

M. Kirsch‐Volders, V. Haufroid, M. Vikkula, 2012 .

Translocation t(2;3)(p15–23;q26–27) in myeloid malignancies: report of 21 new cases, clinical, cytogenetic and molecular genetic features

F. Speleman, A. Hagemeijer, L. Michaux, 2004, Leukemia.

3q rearrangements in myeloid malignancies

F. Speleman, B. Poppe, N. Dastugue, 2011 .

Fabry nephropathy: indications for screening and guidance for diagnosis and treatment by the European Renal Best Practice.

C. Wanner, W. van Biesen, A. Ortiz, 2013, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Two-tier approach for the detection of alpha-galactosidase A deficiency in kidney transplant recipients.

R. Vanholder, K. Claes, B. Maes, 2008, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Identification of Two Critically Deleted Regions within Chromosome Segment 7q35-q36 in EVI1 Deregulated Myeloid Leukemia Cell Lines

F. Speleman, B. Menten, A. De Paepe, 2010, PloS one.

B-cell lymphoma ALK activation by the CLTC-ALK fusion is a recurrent event in large

P. Marynen, F. Speleman, P. D. Paepe, 2013 .

Analysis of the Novel Fanconi Anemia Gene SLX4/FANCP in Familial Breast Cancer Cases

Henk M. W. Verheul, Q. Waisfisz, H. Meijers-Heijboer, 2013, Human mutation.

Cancer Surveillance Guideline for individuals with PTEN hamartoma tumour syndrome

E. Schröck, C. Lázaro, G. Capellá, 2020, European Journal of Human Genetics.

Novel FH mutations in families with hereditary leiomyomatosis and renal cell cancer (HLRCC) and patients with isolated type 2 papillary renal cell carcinoma

L. Thomas, S. Richard, B. Teh, 2011, Journal of Medical Genetics.

Questioning the Pathogenic Role of the GLA p.Ala143Thr "Mutation" in Fabry Disease: Implications for Screening Studies and ERT.

W. van Biesen, R. Vanholder, B. Poppe, 2012, JIMD reports.

Matepair sequencing for the detection of chromosomal aberrations in patients with intellectual disability and congenital malformations

E. Cuppen, G. Mortier, F. Speleman, 2012 .

Wide diversity of PAX 5 alterations in BALL : a GFCH ( Groupe Francophone de Cytogénétique Hématologique ) study

P. Brousset, É. Coyaud, B. Poppe, 2010 .

Novel cryptic chromosomal rearrangements in childhood acute lymphoblastic leukemia detected by multiple color fluorescent in situ hybridization.

F. Speleman, J. Philippé, A. De Paepe, 2005, Haematologica.

Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using m‐FISH

F. Speleman, L. Michaux, A. De Paepe, 2002, Genes, chromosomes & cancer.

Nevoid Basal Cell Carcinoma Syndrome and dysgerminoma: an incidental association?

K. Vossaert, B. Poppe, I. Hoorens, 2016, Journal of the European Academy of Dermatology and Venereology : JEADV.

Breast-cancer risk in families with mutations in PALB2.

Nazneen Rahman, Katri Pylkäs, Arto Mannermaa, 2014, The New England journal of medicine.

Acquired chromosomal rearrangements targeting selected transcription factors: contribution of molecular cytogenetic and expression analyses to the identification of clinically and biologically relevant subgroups in hematological malignancies.

F. Speleman, A. De Paepe, B. Poppe, 2007, Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie.

Prolonged recombinant pregnancy hormone use in BRCA1 and BRCA2 mutation carriers

J. Russo, B. Poppe, H. Depypere, 2021, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

Novel biological insights in T-cell acute lymphoblastic leukemia.

F. Speleman, N. Van Roy, J. Haigh, 2015, Experimental hematology.

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Michael Jones, Peter Kraft, Arnaud Droit, 2017, Nature Genetics.

Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers

W. Chung, R. Nussbaum, F. Couch, 2017, Journal of the National Cancer Institute.

Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

D. Steinemann, F. Couch, B. Bonanni, 2016, PloS one.

Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2

R. Nussbaum, D. Steinemann, F. Couch, 2016, Breast Cancer Research.

Screening for Fabry Disease in Male Patients With Arrhythmia Requiring a Pacemaker or an Implantable Cardioverter-Defibrillator.

B. Poppe, D. Hemelsoet, A. Bondue, 2021, Circulation.

Adults with Down syndrome - health/care considerations for health professionals

G. Buggenhout, B. Poppe, B. Callewaert, 2012 .

Massive parallel amplicon sequencing of the breast cancer genes BRCA1 and BRCA2: opportunities, challenges, and limitations

J. Hellemans, K. Claes, A. De Paepe, 2011, Human mutation.

Copy number alterations and copy number variation in cancer: close encounters of the bad kind

K. Buysse, F. Speleman, B. Menten, 2009, Cytogenetic and Genome Research.

Transcriptome ‐ wide association study of breast cancer risk by estrogen ‐ receptor status

Jack A. Taylor, W. Chung, S. Cross, 2020 .

Future perspectives of genome-scale sequencing

B. Poppe, D. Hemelsoet, W. Steyaert, 2018, Acta clinica Belgica.

A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias

P. Marynen, F. Speleman, J. Vandesompele, 2005, Leukemia.

Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951.

F. Speleman, A. Hagemeijer, H. Cavé, 2004, Blood.

t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Français de Cytogénétique Hématologique (GFCH)

F. Speleman, A. Hagemeijer, H. Cavé, 2003, Leukemia.

The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

F. Speleman, J. Vandesompele, J. Soulier, 2014, Haematologica.

Epigenetics in T‐cell acute lymphoblastic leukemia

F. Speleman, B. Poppe, P. Van Vlierberghe, 2015, Immunological reviews.

Molecular cytogenetic study of 126 unselected T-ALL cases reveals high incidence of TCRβ locus rearrangements and putative new T-cell oncogenes

F. Speleman, A. Hagemeijer, A. Paepe, 2006, Leukemia.

Differentiating pathogenic mutations from polymorphic alterations in the splice sites of BRCA1 and BRCA2

Ludwine Messiaen, Eva Machackova, Anne De Paepe, 2003, Genes, chromosomes & cancer.

PAX5/IGH rearrangement is a recurrent finding in a subset of aggressive B‐NHL with complex chromosomal rearrangements

F. Speleman, P. de Paepe, C. de Wolf‐Peeters, 2005, Genes, chromosomes & cancer.

Clinical, cytogenetic and molecular characteristics of 14 T-ALL patients carrying the TCRβ-HOXA rearrangement: a study of the Groupe Francophone de Cytogénétique Hématologique

F. Speleman, A. Hagemeijer, F. Sigaux, 2007, Leukemia.

Loss of adipocyte phospholipase gene PLAAT3 causes lipodystrophy and insulin resistance due to inactivated arachidonic acid-mediated PPARγ signaling

C. Depienne, B. Poppe, D. Hemelsoet, 2021, bioRxiv.

MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia

F. Speleman, J. Vandesompele, J. Soulier, 2014, Leukemia.

Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia

F. Speleman, J. Soulier, B. Poppe, 2015, Leukemia.

Molecular basis and clinical significance of genetic aberrations in B-cell precursor acute lymphoblastic leukemia.

F. Speleman, N. Van Roy, B. Poppe, 2015, Experimental hematology.

Guidelines for the Li–Fraumeni and heritable TP53-related cancer syndromes

E. Schröck, C. Lázaro, G. Capellá, 2020, European Journal of Human Genetics.

Mate pair sequencing for the detection of chromosomal aberrations in patients with intellectual disability and congenital malformations

Edwin Cuppen, Tom Sante, Sarah Vergult, 2013, European Journal of Human Genetics.

Accurate detection and quantification of epigenetic and genetic second hits in BRCA1 and BRCA2-associated hereditary breast and ovarian cancer reveals multiple co-acting second hits.

A. Vral, M. V. Van Bockstal, D. Deforce, 2018, Cancer letters.

Mutation analysis of RAD51D in non-BRCA1/2 ovarian and breast cancer families

W. Foulkes, P. Tonin, K. Claes, 2012, British Journal of Cancer.

Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.

Mads Thomassen, Nina Ditsch, Muhammad Usman Rashid, 2015, JAMA.

Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer

Jane E. Carpenter, Jack A. Taylor, W. Chung, 2019, Nature Communications.

Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study.

Katherine M. Tucker, W. Chung, R. Nussbaum, 2018, Journal of the National Cancer Institute.

Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation

A. Vral, K. Claes, J. van den Ende, 2016, Breast Cancer Research.

EVI1 overexpression in t(3;17) positive myeloid malignancies results from juxtaposition of EVI1 to the MSI2 locus at 17q22

F. Speleman, A. Hagemeijer, C. Bastard, 2008, Haematologica.

MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia

F. Speleman, J. Vandesompele, N. Van Roy, 2014, Haematologica.

IRF2BPL Is Associated with Neurological Phenotypes.

Henry J. Lin, Rebecca C. Spillmann, Michael F. Wangler, 2018, American journal of human genetics.

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia.

Fang Fang, Frank Speleman, Björn Menten, 2014, Blood.

Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer

Jane E. Carpenter, A. Whittemore, W. Chung, 2016, Nature Communications.

Expression analyses identify MLL as a prominent target of 11q23 amplification and support an etiologic role for MLL gain of function in myeloid malignancies.

C. Bloomfield, F. Speleman, J. Vandesompele, 2004, Blood.

Genome profiling of acute myelomonocytic leukemia: alteration of the MYB locus in MYST3-linked cases

F. Bertucci, D. Birnbaum, F. Speleman, 2009, Leukemia.

GAB2 is a novel target of 11q amplification in AML/MDS

F. Speleman, C. Schoch, K. Wimmer, 2006, Genes, chromosomes & cancer.

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia.

F. Speleman, J. Soulier, E. Clappier, 2014, Blood.

Combined M‐FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines

F. Speleman, J. Vandesompele, A. De Paepe, 2001, Genes, chromosomes & cancer.

Comparison of miRNA profiles of microdissected Hodgkin/Reed‐Sternberg cells and Hodgkin cell lines versus CD77+ B‐cells reveals a distinct subset of differentially expressed miRNAs

F. Speleman, J. Vandesompele, P. de Paepe, 2009, British journal of haematology.

Screening for EVI1: ectopic expression absent in T-cell acute lymphoblastic leukemia patients and cell lines.

F. Speleman, A. Hagemeijer, A. De Paepe, 2006, Cancer genetics and cytogenetics.

Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores

D. Steinemann, F. Couch, O. Olopade, 2017, Journal of Clinical Oncology.

Rapid detection of VHL exon deletions using real-time quantitative PCR

F. Speleman, J. Vandesompele, K. Claes, 2005, Laboratory Investigation.

A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Jane E. Carpenter, Jack A. Taylor, W. Chung, 2021, Nature Communications.

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.

Sandra L. Halverson, A. Whittemore, L. Kiemeney, 2016, Gynecologic oncology.

Rapid and sensitive detection of BRCA1/2 mutations in a diagnostic setting: comparison of two high-resolution melting platforms.

Anne De Paepe, K. Claes, A. De Paepe, 2008, Clinical chemistry.

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Lara E Sucheston-Campbell, Simon G. Coetzee, Dennis J. Hazelett, 2017, Nature Genetics.

Oncogenetic testing and follow-up for women with familial breast/ovarian cancer, Li-Fraumeni syndrome and Cowden syndrome

H. Wildiers, M. Berlière, K. Claes, 2015 .

BRCA1, BRCA2 and PALB2 mutations and CHEK2 c.1100delC in different South African ethnic groups diagnosed with premenopausal and/or triple negative breast cancer

A. Vral, K. Claes, J. Slabbert, 2015, BMC Cancer.

Reply to Kratz et al.

E. Schröck, D. Evans, C. Lázaro, 2020, European Journal of Human Genetics.

DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Olufunmilayo I. Olopade, Mads Thomassen, Torben A. Kruse, 2014, PLoS genetics.

University of Groningen DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers Osorio,

Rensburg, A. Whittemore, D. Steinemann, 2014 .

Soft tissue tumors : clear cell sarcoma

K. Dhaene, F. Speleman, B. Poppe, 2011 .

The H 3 K 27 me 3 demethylase UTX is a gender-speci fi c tumor suppressor in T-cell acute lymphoblastic leukemia

Konstantinos J. Mavrakis, Ari, Pieter, 2014 .

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in early immature T-cell acute lymphoblastic leukemia

F. Speleman, J. Soulier, J. Meijerink, 2014 .

Repetitive Analyses of P-Glycoprotein in Chronic Myeloid Leukaemia

J. Philippé, B. Poppe, B. De Moerloose, 2000, Acta clinica Belgica.

Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia

G. Berx, B. Poppe, P. Van Vlierberghe, 2017, Leukemia.

ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma.

P. Marynen, F. Speleman, P. de Paepe, 2003, Blood.

EVI1‐mediated down regulation of MIR449A is essential for the survival of EVI1 positive leukaemic cells

F. Speleman, J. Vandesompele, J. Philippé, 2011, British journal of haematology.

Molecular cytogenetic and clinical findings in ETV6/ABL1‐positive leukemia

P. Marynen, F. Speleman, A. De Paepe, 2001, Genes, chromosomes & cancer.

Variant Ataxia Telangiectasia: Clinical and Molecular Findings and Evaluation of Radiosensitive Phenotypes in a Patient and Relatives

A. Vral, A. Taylor, K. Claes, 2013, NeuroMolecular Medicine.

Prevalence of Germline Pathogenic Variants in Cancer Predisposing Genes in Czech and Belgian Pancreatic Cancer Patients

M. Blok, S. Tejpar, K. Claes, 2021, Cancers.

Genotyping of frequent BRCA1/2 SNPs with unlabeled probes: a supplement to HRMCA mutation scanning, allowing the strong reduction of sequencing burden.

K. Claes, A. De Paepe, B. Poppe, 2009, The Journal of molecular diagnostics : JMD.

Molecular cytogenetic analysis of 10;11 rearrangements in acute myeloid leukemia

F. Speleman, A. Paepe, B. Poppe, 2002, Leukemia.

Chromosome 2 short arm translocations revealed by M-FISH analysis of neuroblastoma cell lines.

F. Speleman, J. Vandesompele, A. De Paepe, 2000, Medical and pediatric oncology.

Chromosomal radiosensitivity in BRCA1 and BRCA2 mutation carriers

H Thierens, A Vral, H. Thierens, 2004, International journal of radiation biology.

Prevalence of BRCA1/2 mutations in sporadic breast/ovarian cancer patients and identification of a novel de novo BRCA1 mutation in a patient diagnosed with late onset breast and ovarian cancer: implications for genetic testing

K. Claes, A. Paepe, B. Poppe, 2012, Breast Cancer Research and Treatment.

Long noncoding RNA signatures define oncogenic subtypes in T-cell acute lymphoblastic leukemia

F. Speleman, J. Vandesompele, J. Soulier, 2016, Leukemia.

Acute myeloid leukaemia with 8p11 (MYST3) rearrangement: an integrated cytologic, cytogenetic and molecular study by the groupe francophone de cytogénétique hématologique

D. Birnbaum, F. Speleman, G. Flandrin, 2008, Leukemia.

Combined effect of polymorphisms in Rad51 and Xrcc3 on breast cancer risk and chromosomal radiosensitivity.

H. Thierens, A. Vral, K. Claes, 2011, Molecular medicine reports.

IRF2BPL Is Associated with Neurological Phenotypes.

Henry J. Lin, Rebecca C. Spillmann, Michael F. Wangler, 2018, American journal of human genetics.

Characterization of LEDGF/p75 Genetic Variants and Association with HIV-1 Disease Progression

B. Poppe, P. Messiaen, P. Van Acker, 2012, PloS one.

Mutations in RNU7-1 Weaken Secondary RNA Structure, Induce MCP-1 and CXCL10 in CSF, and Result in Aicardi-Goutières Syndrome with Severe End-Organ Involvement

P. Verloo, Y. Crow, B. Ogunjimi, 2022, Journal of Clinical Immunology.

Identification and characterisation of a founder mutation in the Belgian breast/ovarian cancer population

M. Vos, K. Claes, L. Messiaen, 2000 .

Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition

H. Thierens, A. Vral, L. de Ridder, 2002, British Journal of Cancer.

HOXA gene cluster rearrangement in a t(7;9)(p15;q34) in a child with MDS.

F. Speleman, A. De Paepe, B. Poppe, 2005, Cancer genetics and cytogenetics.

Exome Sequencing and Multigene Panel Testing in 1,411 Patients With Adult-Onset Neurologic Disorders

B. Bergmans, B. Poppe, P. Santens, 2023, Neurology: Genetics.

ENIGMA CHEK2gether Project: A Comprehensive Study Identifies Functionally Impaired CHEK2 Germline Missense Variants Associated with Increased Breast Cancer Risk

James M. Hodge, E. Burnside, Y. Kamatani, 2023, Clinical cancer research : an official journal of the American Association for Cancer Research.

Twist exome capture allows for lower average sequence coverage in clinical exome sequencing

Pieter B. T. Neerincx, Spencer J. Gibson, Farid Yavari Dizjikan, 2023, Human Genomics.

A long-term neuropsychological evaluation in Fabry disease

G. Vingerhoets, M. Miatton, B. Poppe, 2020, Acta Neurologica Belgica.

Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction.

V. Pankratz, F. Couch, O. Olopade, 2010, Cancer research.

Epigenetics in T‐cell acute lymphoblastic leukemia

F. Speleman, B. Poppe, P. Van Vlierberghe, 2015, Immunological reviews.

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia.

F. Speleman, J. Soulier, E. Clappier, 2014, Blood.

The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

F. Speleman, J. Vandesompele, J. Soulier, 2014, Haematologica.

No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.

Sandra L. Halverson, A. Whittemore, L. Kiemeney, 2016, Gynecologic oncology.

Comparison of miRNA Profiles of Microdissected Hodgkin/Reed-Sternberg Cells and Hodgkin Cell Lines Versus CD77+ B-Cells Reveals a Distinct Subset of Differentially Expressed miRNAs

F. Speleman, J. Vandesompele, B. Poppe, 2008 .

Variant Ataxia Telangiectasia: Clinical and Molecular Findings and Evaluation of Radiosensitive Phenotypes in a Patient and Relatives

A. Vral, K. Claes, B. Poppe, 2013, NeuroMolecular Medicine.

Transcriptome-wide association study of breast cancer risk by estrogen-receptor status

Jack A. Taylor, S. Cross, C. Vachon, 2020, Genetic epidemiology.

DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

A. Whittemore, D. Steinemann, F. Couch, 2014, PLoS genetics.

Questioning the Pathogenic Role of the GLA p.Ala143Thr "Mutation" in Fabry Disease: Implications for Screening Studies and ERT.

R. Vanholder, K. Claes, B. Poppe, 2012, JIMD reports.