R. Peach

B. Howden, C. Benjamin, R. Peach, 2002, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

Albumin Redhill (-1 Arg, 320 Ala----Thr): a glycoprotein variant of human serum albumin whose precursor has an aberrant signal peptidase cleavage site.

R. Peach, S. Brennan, P. George, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Hypermutability of CpG dinucleotides in the propeptide-encoding sequence of the human albumin gene.

M. Galliano, R. Peach, S. Brennan, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Characterisation of oligosaccharides from a glycoprotein variant of human serum albumin (albumin Casebrook) using high-performance anion-exchange chromatography and nuclear magnetic resonance spectroscopy.

R. Peach, S. Brennan, P. Haynes, 1992, Journal of chromatography.

Structural characterization of a glycoprotein variant of human serum albumin: albumin Casebrook (494 Asp----Asn).

R. Peach, S. Brennan, 1991, Biochimica et biophysica acta.

CD28-B7 blockade prevents the development of experimental autoimmune glomerulonephritis.

R. Peach, M. Sayegh, C. Pusey, 2000, The Journal of clinical investigation.

CD28-b7 blockade in organ dysfunction secondary to cold ischemia/reperfusion injury.

K. Nadeau, R. Peach, M. Sayegh, 1997, Kidney international.

The role of donor and recipient B7-1 (CD80) in allograft rejection.

P. Linsley, A. Sharpe, T. Strom, 1997, Journal of immunology.

Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection.

P. Linsley, R. Peach, M. Sayegh, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Bacterial Pathogens Induce Abscess Formation by CD4+ T-Cell Activation via the CD28–B7-2 Costimulatory Pathway

R. Peach, M. Sayegh, A. Tzianabos, 2000, Infection and Immunity.

Results Melanoma Transfectants Expressing CD 44 H Bind HA More Effectively Than the Same Cells Expressing CD 44

I. Stamenkovic, D. Jackson, A. Bartolazzi, 2002 .

A Role for Inducible Costimulator Protein in the CD28- Independent Mechanism of Resistance to Toxoplasma gondii1

C. Hunter, T. Horan, R. Peach, 2002, The Journal of Immunology.

Toxoplasma gondii Resistance to the CD 28-Independent Mechanism of A Role for Inducible Costimulator Protein in Yoshinaga and

C. Hunter, T. Horan, R. Peach, 2002 .

Effects of blocking B7-1 and B7-2 interactions during a type 2 in vivo immune response.

P. Linsley, F. Finkelman, R. Peach, 1997, Journal of immunology.

RPC4046, a Monoclonal Antibody Against IL13, Reduces Histologic and Endoscopic Activity in Patients With Eosinophilic Esophagitis.

G. Opiteck, D. Penenberg, A. Schoepfer, 2019, Gastroenterology.

The CD28/B7 interaction is not required for resistance to Toxoplasma gondii in the brain but contributes to the development of immunopathology.

C. Hunter, R. Peach, G. Reichmann, 1999, Journal of immunology.

Co-Stimulatory Molecules in Islet Xenotransplantation: CTLA4Ig Treatment in CD40 Ligand-Deficient Mice

H. Ljunggren, R. Peach, O. Korsgren, 2002, Cell transplantation.

B7 Requirements for Primary and Secondary Protein- and Polysaccharide-Specific Ig Isotype Responses to Streptococcus pneumoniae1 2

C. Snapper, R. Peach, W. Gause, 2000, The Journal of Immunology.

Prolongation of fully allogeneic skin graft survival in the rat by combined administration of costimulatory blockade and sirolimus.

C. Benjamin, R. Peach, J. McCall, 2002, Transplantation proceedings.

Abatacept and Belatacept

R. Peach, 2013 .

CD80 Costimulation Is Required for Th2 Cell Cytokine Production But Not for Antigen-Specific Accumulation and Migration into the Lung1

R. Peach, B. Fazekas de St. Groth, F. Ronchese, 2001, The Journal of Immunology.

Migration into the Lung Antigen-Specific Accumulation and Cytokine Production But Not for CD80 Costimulation Is Required for Th2 Cell

R. Peach, F. Ronchese, B. Groth, 2001 .

Prospective assessment of serum periostin as a biomarker for diagnosis and monitoring of eosinophilic oesophagitis

Sara R. Selitsky, J. Parker, J. Woosley, 2016, Alimentary pharmacology & therapeutics.

Role of CD28 in the generation of effector and memory responses required for resistance to Toxoplasma gondii.

C. Hunter, R. Peach, G. Reichmann, 1999, Journal of immunology.

Streptococcus Isotype Responses to Protein- and Polysaccharide-Specific Ig B7 Requirements for Primary and Secondary

C. Snapper, R. Peach, W. Gause, 2000 .

Immunoglobulin fold characteristics of B7–1 (CD80) and B7–2 (CD86)

P. Linsley, J. Bajorath, R. Peach, 1994, Protein science : a publication of the Protein Society.

B 7 Requirements for Primary and Secondary Protein-and Polysaccharide-Specific Ig Isotype Responses to Streptococcus pneumoniae 1 , 2

C. Snapper, R. Peach, W. Gause, 2010 .

Contribution of Interleukin-12 (IL-12) and the CD28/B7 and CD40/CD40 Ligand Pathways to the Development of a Pathological T-Cell Response in IL-10-Deficient Mice

C. Hunter, R. Peach, L. Craig, 2002, Infection and Immunity.

IL-10-Deficient Mice Pathological T-Cell Response in Pathways to the Development of a the CD 28 / B 7 and CD 40 / CD 40 Ligand Contribution of Interleukin-12 ( IL-12 ) and

C. Hunter, R. Peach, L. Craig, 2002 .

Ozanimod (RPC1063) is a potent sphingosine‐1‐phosphate receptor‐1 (S1P1) and receptor‐5 (S1P5) agonist with autoimmune disease‐modifying activity

R. Peach, H. Rosen, E. Roberts, 2016, British journal of pharmacology.

CD28-B7-mediated T cell costimulation in chronic cardiac allograft rejection: differential role of B7-1 in initiation versus progression of graft arteriosclerosis.

R. Peach, M. Sayegh, M. Denton, 2001, The American journal of pathology.

Sphingosine-1-phosphate receptor-1 (S1P1) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease

R. Peach, P. Gonzalez-Cabrera, H. Rosen, 2016, Mucosal Immunology.

Sphingosine-1-phosphate receptor-1 (S1P 1 ) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease

R. Peach, P. Gonzalez-Cabrera, J. Rivera-Nieves, 2017 .

Sa1221 Rpc1063, a Potent, Selective S1P1 Receptor Modulator, Is Active in a Therapeutic IBD Model and Exhibits Favorable PK/PD Properties in Healthy Volunteers

R. Peach, H. Rosen, M. Boehm, 2013 .

Safety and Tolerability of Orally Administered RPC1063, a Novel S1P1 Receptor Modulator, in Healthy Adult Volunteers, Results of a Phase 1 Study (P01.178)

R. Peach, H. Rosen, M. Boehm, 2013 .

RPC1063, a Potent, Selective S1P1 Receptor Modulator, is Active in Therapeutic Inflammatory Bowel Disease Models and Exhibits Favorable PK/PD Properties in Healthy Volunteers

R. Peach, H. Rosen, M. Boehm, 2009 .

Ex vivo treatment of antigen-presenting cells with CTLA4Ig and encephalitogenic peptide prevents experimental autoimmune encephalomyelitis in the Lewis rat.

P. Linsley, S. Khoury, R. Peach, 1996, Journal of immunology.

IL-13-Mediated Worm Expulsion Is B7 Independent and IFN-γ Sensitive1

F. Finkelman, R. Peach, W. Gause, 2000, The Journal of Immunology.

Independent and IFN-IL-13-Mediated Worm Expulsion Is B 7

F. Finkelman, R. Peach, W. Gause, 2000 .

Costimulatory signal blockade in murine relapsing experimental autoimmune encephalomyelitis

S. Khoury, R. Peach, M. Sayegh, 1999, Journal of Neuroimmunology.

Prevention of T-cell activation by rhCTLA4-Ig and anti-CD40L monoclonal antibody results in indefinite islet allograft survival.

T. Starzl, R. Peach, J. Fung, 1999, Transplantation proceedings.

Mechanisms underlying the development of T-cell tolerance following interruption of signalling at the CD28/B7 and CD40/gp39 interface.

T. Starzl, R. Peach, J. Fung, 1999, Transplantation proceedings.

Crystallization and preliminary X-ray analysis of CTLA-4 (CD152) membrane-external domain.

W. Fenderson, S. Sheriff, R. Peach, 2000, Acta crystallographica. Section D, Biological crystallography.

The processing of human proinsulin and chicken proalbumin by rat hepatic vesicles suggests a convertase specific for X-Y-Arg-Arg or Arg-X-Y-Arg sequences.

R. Peach, S. Brennan, 1991, The Journal of biological chemistry.

Potentiates CD8+ T Cell Activation and CTL Activation, Whereas CD80 Blockade In Vivo CD86 Blockade Inhibits CD4+ T Cell

R. Peach, P. Nguyen, C. Via, 2013 .

In Vivo CD86 Blockade Inhibits CD4+ T Cell Activation, Whereas CD80 Blockade Potentiates CD8+ T Cell Activation and CTL Effector Function1

R. Peach, W. Gause, P. Nguyen, 2002, The Journal of Immunology.

Effector Function T Cell Activation and CTL + Potentiates CD8 Activation, Whereas CD80 Blockade T Cell + In Vivo CD86 Blockade Inhibits CD4

R. Peach, W. Gause, P. Nguyen, 2002 .

The combined use of sublethal irradiation and costimulatory blockade to generate mixed bone marrow chimeras.

R. Peach, J. Fung, R. Kuddus, 1999, Transplantation proceedings.

Ozanimod (RPC1063), a selective S1PR1 and S1PR5 modulator, reduces chronic inflammation and alleviates kidney pathology in murine systemic lupus erythematosus

Matthew E. Stokes, G. Opiteck, R. Peach, 2018, PloS one.

Specificity of yeast KEX2 protease for variant human proalbumins is identical to the in vivo specificity of the hepatic proalbumin convertase.

R. Peach, S. Brennan, I. Bathurst, 1990, The Journal of biological chemistry.

Identification of a calcium-dependent microsomal proteinase responsible for monobasic cleavage of chicken proalbumin.

R. Peach, S. Brennan, 1989, Biochimica et biophysica acta.

Rational Development of LEA29Y (belatacept), a High‐Affinity Variant of CTLA4‐Ig with Potent Immunosuppressive Properties

P. Linsley, J. Bajorath, R. Peach, 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Results From the First‐in‐Human Study With Ozanimod, a Novel, Selective Sphingosine‐1‐Phosphate Receptor Modulator

R. Peach, H. Rosen, M. Boehm, 2017, Journal of clinical pharmacology.

CD28/CTLA-4 receptor structure, binding stoichiometry and aggregation during T-cell activation.

P. Linsley, J. Bajorath, R. Peach, 1995, Research in immunology.

Calcium‐dependent KEX2‐like protease found in hepatic secretory vesicles converts proalbumin to albumin

R. Peach, S. Brennan, Robert J. Peach, 1988, FEBS letters.

The murine homolog of human Ep‐CAM, a homotypic adhesion molecule, is expressed by thymocytes and thymic epithelial cells

R. Peach, A. Aruffo, A. Farr, 1996, European journal of immunology.

Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection

Robert Peach, Hugh Rosen, Edward Roberts, 2011, Cell.

Differential Requirement for CD80 and CD80/CD86-Dependent Costimulation in the Lung Immune Response to an Influenza Virus Infection1

Nicola L. Harris, Franca Ronchese, Joanna M. Roberts, 2000, The Journal of Immunology.

Infection Response to an Influenza Virus Costimulation in the Lung Immune and CD 80 / CD 86-Dependent Differential Requirement for CD 80

Joanna M. Roberts, R. Peach, F. Ronchese, 1999 .

Ultrastructural localization of Tamm—Horsfall protein in human kidney using immunogold electron microscopy

W. A. Day, R. Peach, A. McGiven, 1988, The Histochemical Journal.

Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28

K. Constantine, L. Mueller, P. Linsley, 1997, Nature Structural Biology.

Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1

P. Linsley, J. Bajorath, R. Peach, 1994, The Journal of experimental medicine.

Binding Stoichiometry of the Cytotoxic T Lymphocyte-associated Molecule-4 (CTLA-4)

P. Linsley, J. Bajorath, J. Bradshaw, 1995, The Journal of Biological Chemistry.

Identification of hyaluronic acid binding sites in the extracellular domain of CD44

I. Stamenkovic, R. Peach, A. Aruffo, 1993, The Journal of cell biology.

Structural biology of the S1P1 receptor.

M. Hanson, R. Peach, 2014, Current topics in microbiology and immunology.

A sensitive and specific ELISA using a monoclonal capture antibody for detection of Tamm-Horsfall urinary glycoprotein in serum.

K. Lynn, R. Peach, J. S. Hunt, 1986, JIM - Journal of Immunological Methods.

The effects of B7‐dependent costimulation on T cell division and survival in vivo and in vitro are dependent on antigen concentration

R. Peach, F. Ronchese, J. Lumsden, 2003, European journal of immunology.

Novel human proalbumin variant with intact dibasic sequence facilitates identification of its converting enzyme.

R. Peach, S. Brennan, D. Boswell, 1989, Biochimica et biophysica acta.

Cardiac Safety of Ozanimod, a Novel Sphingosine‐1‐Phosphate Receptor Modulator: Results of a Thorough QT/QTc Study

R. Peach, M. Boehm, A. Olson, 2017, Clinical pharmacology in drug development.

Metabolites of RPC1063 Contribute to In Vivo Efficacy (P05.157)

R. Peach, M. Boehm, F. Scott, 2013 .

of Genetic Variants of Human Serum

R. Peach, P. George, J. Sheat, 2004 .

Rapid detection and initial characterization of genetic variants of human serum albumin.

R. Peach, P. George, J. Sheat, 1991, Clinical Chemistry.

Albumin Rugby Park: a truncated albumin variant caused by a G-->C splice-site mutation in intron 13.

R. Peach, S. Brennan, P. George, 1992, Biochimica et Biophysica Acta.

Prediction of the site of signal peptidase cleavage in normal and variant human preproalbumin.

R. Peach, S. Brennan, D. Boswell, 1991, Protein sequences & data analysis.

RapidDetectionand InitialCharacterization Albumin

R. Peach, P. George, J. Sheat, 1991 .

and Migration into the Lung for Antigen-Specific Accumulation Not Th2 Cell Cytokine Production But CD80 Costimulation Is Required for

Robert Peach, Nicola L. Harris, Franca Ronchese, 2010 .

IL-13-mediated worm expulsion is B7 independent and IFN-gamma sensitive.

F. Finkelman, R. Peach, J. Urban, 2000, Journal of immunology.

CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia

Robert Peach, Peter S. Linsley, Franca Ronchese, 1997, The Journal of experimental medicine.

Presentation of MHC-disparate donor antigens predominantly by the indirect pathway results in the development of posttransplant vasculopathy: salutary effects of perioperative costimulatory blockade.

R. Peach, J. Fung, V. Subbotin, 2001, Transplantation Proceedings.

Blockade of the CD28/B7 and CD40/CD40L costimulatory pathways does not ameliorate chronic rejection in a mouse aortic allograft model of direct antigen presentation.

R. Peach, J. Fung, V. Subbotin, 2001, Transplantation proceedings.

Differential effects of B7-1 blockade in the rat experimental autoimmune encephalomyelitis model.

P. Linsley, S. Khoury, R. Peach, 1997, Journal of immunology.

Administration of CTLA4-Ig enhances the incidence of hamster-to-rat xenogeneic bone marrow engraftment and alters the presentation of graft-vs-host disease.

R. Peach, J. Fung, V. Subbotin, 2000, Transplantation proceedings.

Endoproteolytic processing of recombinant proalbumin variants by the yeast Kex2 protease.

R. Peach, S. Brennan, P. George, 1995, The Biochemical journal.

Structural biology of the S1P1 receptor.

M. Hanson, R. Peach, 2014, Current topics in microbiology and immunology.