J. McLaurin

P. Fraser, J. McLaurin, W. Kuhns, 1999, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Immortalization and characterization of rat microglial cells

J. Antel, K. Williams, J. McLaurin, 1995, Neuropathology and applied neurobiology.

Venular amyloid accumulation in transgenic Fischer 344 Alzheimer’s disease rats

J. McLaurin, A. Lai, T. Beckett, 2022, Scientific Reports.

Interaction of human and mouse Abeta peptides.

J. McLaurin, A. Chakrabartty, Justin Fung, 2004, Journal of neurochemistry.

A human glial hybrid cell line differentially expressing genes subserving oligodendrocyte and astrocyte phenotype.

J. McLaurin, N. Cashman, I. Shaw, 1995, Journal of neurobiology.

Phenotypic and cell cycle properties of human oligodendrocytes in vitro

E. Wang, J. Antel, J. McLaurin, 1995, Brain Research.

α‐Synuclein–synaptosomal membrane interactions

P. Fraser, J. McLaurin, A. Tandon, 2004 .

Microglial pilgrimage to the brain

J. McLaurin, 2010, Nature Medicine.

An Antibody Specific for Component 8 of Myelin Basic Protein from Normal Brain Reacts Strongly with Component 8 from Multiple Sclerosis Brain

J. McLaurin, M. Moscarello, G. Hashim, 1992, Journal of neurochemistry.

A Hydroxyproline‐Containing Protein from Shark Brain That Is Related to Myelin Basic Protein

J. McLaurin, D. Wood, M. Moscarello, 1990, Journal of neurochemistry.

Selective targeting of perivascular macrophages for β-amyloid clearance in cerebral amyloid angiopathy

J. McLaurin, C. Hawkes, 2009, Alzheimer's & Dementia.

Editorial: Intramural Vascular Cells: Key Therapeutic Targets for Vascular Cognitive Impairment

R. Carare, J. McLaurin, S. Saito, 2020, Frontiers in Aging Neuroscience.

Aβ(1-42) assembly in the presence of scyllo-inositol derivatives: identification of an oxime linkage as important for the development of assembly inhibitors.

C. Yip, J. McLaurin, A. Lai, 2012, ACS chemical neuroscience.

Ascl1 phospho-site mutations enhance neuronal conversion of adult cortical astrocytes in vivo

James R. Mester, D. Zinyk, C. Schuurmans, 2022, Frontiers in Neuroscience.

CHRNA5 links chandelier cells to protection against amyloid pathology in human aging and Alzheimer’s Disease

J. Schneider, E. Lambe, P. D. De Jager, 2023, bioRxiv.

Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model

D. Westaway, P. Fraser, P. George-Hyslop, 2006, Nature Medicine.

Synthesis of scyllo-inositol derivatives and their effects on amyloid beta peptide aggregation.

J. McLaurin, Guohua Zhang, C. Hawkes, 2008, Bioorganic & medicinal chemistry.

scyllo-Inositol, preclinical, and clinical data for Alzheimer's disease.

J. McLaurin, L. Thomason, K. Ma, 2012, Advances in pharmacology.

Small molecule inhibitors of Aβ‐aggregation and neurotoxicity

JoAnne McLaurin, J. McLaurin, C. Hawkes, 2009 .

Imaging the Perivascular Space as a Potential Biomarker of Neurovascular and Neurodegenerative Diseases

Fuqiang Gao, Joel Ramirez, Courtney Berezuk, 2016, Cellular and Molecular Neurobiology.

Properties of scyllo–inositol as a therapeutic treatment of AD-like pathology

J. McLaurin, Mary E. Brown, D. Fenili, 2007, Journal of Molecular Medicine.

Review: Modulating Factors in Amyloid-β Fibril Formation

P. Fraser, C. Yip, J. McLaurin, 2000 .

Reduced Tissue Levels of Noradrenaline Are Associated with Behavioral Phenotypes of the TgCRND8 Mouse Model of Alzheimer's Disease

J. McLaurin, H. Mount, B. Michalski, 2012, Neuropsychopharmacology.

Neurovascular unit remodelling in the subacute stage of stroke recovery

Peter L. Carlen, Paolo Bazzigaluppi, Greg J. Stanisz, 2017, NeuroImage.

Identification and Structural Characterisation of Carboxy-Terminal Polypeptides and Antibody Epitopes of Alzheimer's Amyloid Precursor Protein Using High-Resolution Mass Spectrometry

P. S. St George-Hyslop, M. Ehrmann, J. McLaurin, 2005, European journal of mass spectrometry.

The role of the immune system in Alzheimer disease: Etiology and treatment

J. McLaurin, M. Salter, S. Jevtic, 2017, Ageing Research Reviews.

Examining the zinc binding site of the amyloid-β peptide

D. Westaway, P. Fraser, K. Qin, 2000 .

Examining the zinc binding site of the amyloid-beta peptide.

D. Westaway, P. Fraser, K. Qin, 2000, European journal of biochemistry.

Determining composition of micron-scale protein deposits in neurodegenerative disease by spatially targeted optical microproteomics

A. Emili, L. Hazrati, J. McLaurin, 2015, eLife.

Rho‐associated protein kinases as therapeutic targets for both vascular and parenchymal pathologies in Alzheimer's disease

J. McLaurin, A. Lai, 2018, Journal of neurochemistry.

Structural Transitions Associated with the Interaction of Alzheimer β-Amyloid Peptides with Gangliosides*

P. Fraser, J. McLaurin, A. Chakrabartty, 1998, The Journal of Biological Chemistry.

α-Synuclein aggregation, seeding and inhibition by scyllo-inositol.

J. McLaurin, Tarek M. Ibrahim, 2016, Biochemical and biophysical research communications.

Region-specific distribution of β-amyloid peptide and cytokine expression in TgCRND8 mice

J. McLaurin, H. Mount, K. Ma, 2011, Neuroscience Letters.

CD163 identifies perivascular macrophages in normal and viral encephalitic brains and potential precursors to perivascular macrophages in blood.

S. Westmoreland, K. Williams, J. McLaurin, 2006, The American journal of pathology.

Investigating the efficacy of a combination Aβ-targeted treatment in a mouse model of Alzheimer’s disease

K. Hynynen, M. O’Reilly, J. McLaurin, 2018, Brain Research.

Interaction between therapeutic interventions for Alzheimer’s disease and physiological Aβ clearance mechanisms

J. McLaurin, Mingzhe Liu, S. Black, 2015, Front. Aging Neurosci..

Membrane Disruption by Alzheimer β-Amyloid Peptides Mediated through Specific Binding to Either Phospholipids or Gangliosides

J. McLaurin, A. Chakrabartty, 1996, The Journal of Biological Chemistry.

Clearance of amyloid-β peptides by microglia and macrophages: the issue of what, when and where.

J. McLaurin, A. Lai, 2012, Future neurology.

Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

Ralph A. Nixon, Paul M. Mathews, Patrick Horne, 2000, Nature.

Small molecule β‐amyloid inhibitors that stabilize protofibrillar structures in vitro improve cognition and pathology in a mouse model of Alzheimer’s disease

J. McLaurin, C. Hawkes, James E. Shaw, 2010, The European journal of neuroscience.

scyllo-Inositol Promotes Robust Mutant Huntingtin Protein Degradation*

J. McLaurin, A. Lai, Salwa Hasan, 2013, The Journal of Biological Chemistry.

Phosphatidylinositol and inositol involvement in Alzheimer amyloid-beta fibril growth and arrest.

P. Fraser, J. McLaurin, A. Chakrabartty, 1998, Journal of molecular biology.

Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants

J. Bowie, Sanguk Kim, P. Fraser, 2008, BMC Neuroscience.

Multiphoton ANS fluorescence microscopy as an in vivo sensor for protein misfolding stress

S. Croul, A. Guha, J. McLaurin, 2011, Cell Stress and Chaperones.

Neurogliovascular dysfunction in a model of repeated traumatic brain injury

James R. Mester, E. Barbier, J. Sled, 2018, Theranostics.

The expression of apoptosis inducing factor (AIF) is associated with aging-related cell death in the cortex but not in the hippocampus in the TgCRND8 mouse model of Alzheimer’s disease

J. McLaurin, R. Quirion, J. Chabot, 2014, BMC Neuroscience.

Wild‐type Shadoo proteins convert to amyloid‐like forms under native conditions

D. Westaway, P. Fraser, J. McLaurin, 2010, Journal of neurochemistry.

Immunotherapy as treatment for Alzheimer’s disease

J. McLaurin, C. Hawkes, 2007, Expert review of neurotherapeutics.

Characterization of the interactions of Alzheimer beta-amyloid peptides with phospholipid membranes.

J. McLaurin, A. Chakrabartty, JoAnne McLaurin, 1997, European journal of biochemistry.

Effect of tumor necrosis factor alpha and beta on human oligodendrocytes and neurons in culture.

J. Antel, J. McLaurin, J. Nalbantoglu, 1995, International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.

Biophysical characterization of longer forms of amyloid beta peptides: possible contribution to flocculent plaque formation

J. McLaurin, M. Lambermon, Rebecca V. Rappaport, 2005, Journal of neurochemistry.

Interaction of human and mouse Aβ peptides

J. McLaurin, A. Chakrabartty, Justin Fung, 2004 .

Current Concepts and Future Prospects for Alzheimer Disease Vaccines

F. Heppner, S. Gandy, J. McLaurin, 2004, Alzheimer disease and associated disorders.

Early neurovascular dysfunction in a transgenic rat model of Alzheimer’s disease

John G. Sled, Margaret M. Koletar, Bojana Stefanovic, 2017, Scientific Reports.

Mechanisms of Amyloid-Beta Peptide Uptake by Neurons: The Role of Lipid Rafts and Lipid Raft-Associated Proteins

J. McLaurin, A. Lai, 2010, International journal of Alzheimer's disease.

Cholesterol, a modulator of membrane-associated Abeta-fibrillogenesis and neurotoxicity.

J McLaurin, C. Yip, J. McLaurin, 2001, Journal of molecular biology.

Protein seeding in Alzheimer’s disease and Parkinson’s disease: Similarities and differences

J. McLaurin, Tarek M. Ibrahim, 2014 .

Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound

Kullervo Hynynen, JoAnne McLaurin, Isabelle Aubert, 2013, Experimental Neurology.

Aβ42-Peptide Assembly on Lipid Bilayers

C. Yip, J. McLaurin, A. Darabie, 2002 .

α-Synuclein Membrane Interactions and Lipid Specificity*

P. S. St George-Hyslop, P. Fraser, C. Yip, 2000, The Journal of Biological Chemistry.

Amyloid-beta peptide assembly: a critical step in fibrillogenesis and membrane disruption.

C. Yip, J. McLaurin, 2001, Biophysical journal.

Requirement of aggregation propensity of Alzheimer amyloid peptides for neuronal cell surface binding

J. McLaurin, A. Chakrabartty, David A. Bateman, 2007, BMC Neuroscience.

α-Melanocyte Stimulating Hormone Prevents GABAergic Neuronal Loss and Improves Cognitive Function in Alzheimer's Disease

J. McLaurin, K. Ma, 2014, The Journal of Neuroscience.

Cerebrovascular contributions to Alzheimer's disease pathophysiology and potential therapeutic interventions in mouse models

J. McLaurin, B. Stefanovic, L. Thomason, 2013, The European journal of neuroscience.

Effects of Neurotrophic Support and Amyloid-Targeted Combined Therapy on Adult Hippocampal Neurogenesis in a Transgenic Model of Alzheimer's Disease

J. McLaurin, L. Thomason, I. Aubert, 2016, PloS one.

Amyloid-β fibrillogenesis: Structural insight and therapeutic intervention

J. McLaurin, James E. Shaw, Kevin A. Dasilva, 2010, Experimental Neurology.

Imaging the Effects of &bgr;-Hydroxybutyrate on Peri-Infarct Neurovascular Function and Metabolism

James R. Mester, Evelyn M. R. Lake, G. Stanisz, 2018, Stroke.

The Effects of Delayed Reduction of Tonic Inhibition on Ischemic Lesion and Sensorimotor Function

Evelyn M. R. Lake, D. Corbett, G. Stanisz, 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Refining an Alzheimer’s vaccine to avoid an inflammatory response

J. McLaurin, Kevin A. Dasilva, Mary Brown, 2005, Expert opinion on biological therapy.

Amyloid-beta interactions with chondroitin sulfate-derived monosaccharides and disaccharides. implications for drug development.

P. Fraser, J. McLaurin, A. Darabie, 2001, The Journal of biological chemistry.

Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.

P. S. St George-Hyslop, D. Westaway, P. Fraser, 2002, Nature medicine.

Reduced oligomeric and vascular amyloid-beta following immunization of TgCRND8 mice with an Alzheimer's DNA vaccine.

J. McLaurin, Kevin A. Dasilva, Mary Brown, 2009, Vaccine.

Cerebrovascular damage after midlife transient hypertension in non-transgenic and Alzheimer’s disease rats

A. Dorr, J. McLaurin, B. Stefanovic, 2021, Brain Research.

Attenuation of tonic inhibition prevents chronic neurovascular impairments in a Thy1-ChR2 mouse model of repeated, mild traumatic brain injury

James R. Mester, J. Sled, A. Dorr, 2021, Theranostics.

Refinement of a chronic cranial window implant in the rat for longitudinal in vivo two–photon fluorescence microscopy of neurovascular function

A. Dorr, J. McLaurin, B. Stefanovic, 2019, Scientific Reports.

Impaired Cholinergic Excitation of Prefrontal Attention Circuitry in the TgCRND8 Model of Alzheimer's Disease

E. Lambe, P. Fraser, J. McLaurin, 2015, The Journal of Neuroscience.

α-Melanocyte Stimulating Hormone as a Potential Therapy for Alzheimer`s Disease.

J. McLaurin, K. Ma, 2016, Current Alzheimer research.

Interactions of Alzheimer amyloid-beta peptides with glycosaminoglycans effects on fibril nucleation and growth.

P. Fraser, X. Zhang, J. McLaurin, 1999, European journal of biochemistry.

Cellular membrane composition defines A beta-lipid interactions.

P. Fraser, S. Waschuk, J. McLaurin, 2001, The Journal of biological chemistry.

The effects of voluntary running on cerebrovascular morphology and spatial short-term memory in a mouse model of amyloidosis

John G. Sled, Joe Steinman, Adrienne Dorr, 2020, NeuroImage.

Reactivity of two anti-galactosyl ceramide antibodies towards myelin basic protein

J. McLaurin, M. Moscarello, 1992, Journal of the Neurological Sciences.

The preparation of antibodies reactive against citrulline-containing charge isomers of myelin basic protein but not against the arginine-containing charge isomers.

J. McLaurin, M. Moscarello, 1990, Analytical Biochemistry.

Localization of basic proteins in human myelin

C. Ackerley, J. McLaurin, M. Moscarello, 1993, Journal of neuroscience research.

Sodium/myo-Inositol Transporters: Substrate Transport Requirements and Regional Brain Expression in the TgCRND8 Mouse Model of Amyloid Pathology

J. McLaurin, I. Aubert, M. Nitz, 2011, PloS one.

Regional differences in Alzheimer’s disease pathology confound behavioural rescue after amyloid-β attenuation

Paolo Bazzigaluppi, J. McLaurin, B. Stefanovic, 2019, Brain : a journal of neurology.

Potential Role of Venular Amyloid in Alzheimer’s Disease Pathogenesis

J. McLaurin, J. Bishay, C. D. Morrone, 2020, International journal of molecular sciences.

MK886 Reduces Cerebral Amyloid Angiopathy Severity in TgCRND8 Mice

R. Carare, J. McLaurin, C. Hawkes, 2013, Neurodegenerative Diseases.

Modulation of the peri‐infarct neurogliovascular function by delayed COX‐1 inhibition

James R. Mester, Evelyn M. R. Lake, G. Stanisz, 2017, Journal of magnetic resonance imaging : JMRI.

Cholesterol, a Modulator of Membrane‐Associated Aβ‐Fibrillogenesis

J. McLaurin, A. Darabie, M. Morrison, 2002, Pharmacopsychiatry.

Amyloid-β Interactions with Chondroitin Sulfate-derived Monosaccharides and Disaccharides

P. Fraser, J. McLaurin, A. Darabie, 2001, Journal of Biological Chemistry.

Apamin Improves Prefrontal Nicotinic Impairment in Mouse Model of Alzheimer's Disease.

E. Lambe, J. McLaurin, É. Proulx, 2019, Cerebral cortex.

Immunotherapy for Alzheimer's disease

P. S. St George-Hyslop, J. McLaurin, D. Fenili, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Clinical immunotherapy trials in Alzheimer’s disease

J. McLaurin, C. Hawkes, 2008 .

Immunization with amyloid-β using GM-CSF and IL-4 reduces amyloid burden and alters plaque morphology

D. Westaway, J. McLaurin, Kevin A. Dasilva, 2006, Neurobiology of Disease.

CHRNA5 links chandelier cells to protection against amyloid pathology in human aging and Alzheimer’s Disease

E. Lambe, P. D. De Jager, S. Tripathy, 2023, bioRxiv.

Amyloid-β-dependent compromise of microvascular structure and function in a model of Alzheimer's disease.

Bojana Stefanovic, Adrienne Dorr, Bhupinder Sahota, 2012, Brain : a journal of neurology.

Covert strokes prior to Alzheimer’s disease onset accelerate peri-lesional pathology but not cognitive deficits in an inducible APP mouse model

A. Dorr, J. McLaurin, B. Stefanovic, 2021, Brain Research.

Phenotypic and functional changes in glial cells as a function of age

D. Westaway, P. Fraser, J. McLaurin, 2002, Neurobiology of Aging.

Immune and non-immune actions of interferon-β-1b on primary human neural cells

J. McLaurin, J. Antel, V. Yong, 1995 .

A b peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer ' s disease

D. Westaway, P. Fraser, P. George-Hyslop, 2022 .

Cholesterol, a Modulator of Membrane-associated Aβ-fibrillogenesis

J. McLaurin, A. Darabie, M. Morrison, 2003, Annals of the New York Academy of Sciences.

Utilizing supervised machine learning to identify microglia and astrocytes in situ: implications for large-scale image analysis and quantification

M Liu, J Ylanko, E Weekman, 2019, Journal of Neuroscience Methods.

Cognitive Characteristics of TgAPP CRND8 Mice Immunised with Beta Amyloid Peptide

D. Westaway, P. George-Hyslop, J. McLaurin, 2003 .

Hippocampal GABAergic neurons are susceptible to amyloid-β toxicity in vitro and are decreased in number in the Alzheimer's disease TgCRND8 mouse model.

J. McLaurin, R. Quirion, J. Chabot, 2012, Journal of Alzheimer's disease : JAD.

Assembly of Alzheimer's amyloid-beta fibrils and approaches for therapeutic intervention.

D. Westaway, L. Serpell, P. Fraser, 2001, Amyloid: Journal of Protein Folding Disorders.

Abeta42-peptide assembly on lipid bilayers.

C. Yip, J. McLaurin, A. Darabie, 2002, Journal of molecular biology.

Combinatorial Treatment Using Umbilical Cord Perivascular Cells and Aβ Clearance Rescues Vascular Function Following Transient Hypertension in a Rat Model of Alzheimer Disease

A. Dorr, Paolo Bazzigaluppi, J. McLaurin, 2019, Hypertension.

Cholesterol and apoe: a target for Alzheimer's disease therapeutics.

J. McLaurin, D. Fenili, 2005, Current Drug Targets - CNS & Neurological Disorders.

Alzheimer disease: advances in pathogenesis, diagnosis, and therapy.

D. Holtzman, E. Diamandis, J. McLaurin, 2011, Clinical chemistry.

scyllo-Inositol Promotes Robust Mutant Huntingtin Protein Degradation*

J. McLaurin, A. Lai, Salwa Hasan, 2013, The Journal of Biological Chemistry.

Vaccine Development for Alzheimers Disease

J. McLaurin, I. Aubert, Kevin A. Dasilva, 2006 .

Review: modulating factors in amyloid-beta fibril formation.

P. Fraser, C. Yip, J. McLaurin, 2000, Journal of structural biology.

Small molecule β‐amyloid inhibitors that stabilize protofibrillar structures in vitro improve cognition and pathology in a mouse model of Alzheimer’s disease

J. McLaurin, C. Hawkes, James E. Shaw, 2010, The European journal of neuroscience.

Amyloid beta-protein (A beta) associated with lipid molecules: immunoreactivity distinct from that of soluble A beta.

Y. Ihara, J. McLaurin, A. Chakrabartty, 1997, FEBS letters.

Region-specific distribution of β-amyloid peptide and cytokine expression in TgCRND8 mice

J. McLaurin, H. Mount, K. Ma, 2011, Neuroscience Letters.

Immune and non-immune actions of interferon-beta-Ib on primary human neural cells.

J. Antel, J. McLaurin, V. Yong, 1995, Multiple Sclerosis.