E. van de Steeg

发表

Regional Expression Levels of Drug Transporters and Metabolizing Enzymes along the Pig and Human Intestinal Tract and Comparison with Caco-2 Cells

R. Pieters, S. Vaessen, M. V. van Lipzig, 2017, Drug Metabolism and Disposition.

Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes.

J. Wiśniewski, P. Artursson, T. Andersson, 2017, Molecular pharmaceutics.

Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs.

E. van de Steeg, A. Schinkel, E. Wagenaar, 2010, The Journal of clinical investigation.

Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling.

Sieto Bosgra, K. Verhoeckx, H. Wortelboer, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

A new approach to predict human intestinal absorption using porcine intestinal tissue and biorelevant matrices.

Cyrille A M Krul, C. Krul, H. Wortelboer, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Towards human ex vivo organ perfusion models to elucidate drug pharmacokinetics in health and disease

E. van de Steeg, W. Vaes, C. Knibbe, 2020, Drug metabolism reviews.

OATP1A/1B Transporters Affect Irinotecan and SN-38 Pharmacokinetics and Carboxylesterase Expression in Knockout and Humanized Transgenic Mice

E. van de Steeg, O. van Tellingen, M. Ludwig, 2013, Molecular Cancer Therapeutics.

Intestine-on-a-chip: Next level in vitro research model of the human intestine

E. van de Steeg, J. Donkers, H. Eslami Amirabadi, 2020 .

Advanced epithelial lung and gut barrier models demonstrate passage of microplastic particles

I. Kooter, E. van de Steeg, Lena Will, 2022, Microplastics and Nanoplastics.

Influence of Human OATP1B1, OATP1B3, and OATP1A2 on the Pharmacokinetics of Methotrexate and Paclitaxel in Humanized Transgenic Mice

E. van de Steeg, A. Schinkel, E. Wagenaar, 2012, Clinical Cancer Research.

Organic Anion-Transporting Polypeptide 1B1 Mediates Transport of Gimatecan and BNP1350 and Can Be Inhibited by Several Classic ATP-Binding Cassette (ABC) B1 and/or ABCG2 Inhibitors

J. Schellens, J. Beijnen, E. van de Steeg, 2009, Drug Metabolism and Disposition.

Murine Oatp1a/1b Uptake Transporters Control Rosuvastatin Systemic Exposure Without Affecting Its Apparent Liver Exposure

E. van de Steeg, A. Schinkel, E. Wagenaar, 2013, Molecular Pharmacology.

Species-Dependent Transport and Modulation Properties of Human and Mouse Multidrug Resistance Protein 2 (MRP2/Mrp2, ABCC2/Abcc2)

E. van de Steeg, A. Schinkel, E. Wagenaar, 2008, Drug Metabolism and Disposition.

Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants

D. Tibboel, M. V. van Lipzig, H. Wortelboer, 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Human OATP1B1, OATP1B3 and OATP1A2 can mediate the in vivo uptake and clearance of docetaxel

H. Rosing, J. Beijnen, E. van de Steeg, 2015, International journal of cancer.

Drug-Drug Interactions between Rosuvastatin and Oral Antidiabetic Drugs Occurring at the Level of OATP1B1

K. Verhoeckx, M. Monshouwer, H. Wortelboer, 2013, Drug Metabolism and Disposition.

Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs

J. Proost, G. Groothuis, M. V. van Lipzig, 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

A proof of concept using the Ussing chamber methodology to study pediatric intestinal drug transport and age‐dependent differences in absorption

S. Botden, A. Ungell, E. van de Steeg, 2022, Clinical and translational science.

An Ex Vivo Fermentation Screening Platform to Study Drug Metabolism by Human Gut Microbiota

G. S. Walker, R. Obach, E. van de Steeg, 2018, Drug Metabolism and Disposition.

Combined Analysis of Pharmacokinetic and Efficacy Data of Preclinical Studies with Statins Markedly Improves Translation of Drug Efficacy to Human Trials

H. Wortelboer, E. van de Steeg, W. Duyvenvoorde, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Organic anion-transporting polypeptides 1a/1b control the hepatic uptake of pravastatin in mice.

J. Beijnen, E. van de Steeg, A. Schinkel, 2012, Molecular pharmaceutics.

The Progress of Intestinal Epithelial Models from Cell Lines to Gut-On-Chip

W. D. de Jonge, E. van de Steeg, T. Hakvoort, 2021, International journal of molecular sciences.

Functions of OATP1A and 1B transporters in vivo: insights from mouse models.

E. van de Steeg, A. Schinkel, D. Iusuf, 2012, Trends in pharmacological sciences.

The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo.

M. D. de Jager, I. A. D. de Graaf, G. Groothuis, 2017, Toxicology in vitro : an international journal published in association with BIBRA.

Application of proteomics to understand maturation of drug metabolizing enzymes and transporters for the optimization of pediatric drug therapy

E. van de Steeg, F. Russel, S. D. de Wildt, 2021, Drug Discovery Today: Technologies.

High Impact of Oatp1a/1b Transporters on In Vivo Disposition of the Hydrophobic Anticancer Drug Paclitaxel

E. van de Steeg, O. van Tellingen, A. Schinkel, 2010, Clinical Cancer Research.

Methotrexate Pharmacokinetics in Transgenic Mice with Liver-Specific Expression of Human Organic Anion-Transporting Polypeptide 1B1 (SLCO1B1)

E. van de Steeg, A. Schinkel, E. Wagenaar, 2009, Drug Metabolism and Disposition.

Mechanisms and immunomodulatory properties of pre- and probiotics.

E. van de Steeg, J. V. van Bilsen, M. Meijerink, 2019, Beneficial microbes.

Comparison of In Vitro Assays in Selecting Radiotracers for In Vivo P-Glycoprotein PET Imaging

A. Lammertsma, A. Windhorst, N. Colabufo, 2017, Pharmaceuticals.

Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver.

E. van de Steeg, H. Hartmannová, L. Nosková, 2012, The Journal of clinical investigation.

Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model.

T. Bayer, A. Delacourte, C. Schmitz, 2004, The American journal of pathology.

Feasibility of SPECT-CT Imaging to Study the Pharmacokinetics of Antisense Oligonucleotides in a Mouse Model of Duchenne Muscular Dystrophy.

E. van de Steeg, B. Aguilera, P. C. de Visser, 2017, Nucleic acid therapeutics.

Impact of Abcc2 [Multidrug Resistance-Associated Protein (Mrp) 2], Abcc3 (Mrp3), and Abcg2 (Breast Cancer Resistance Protein) on the Oral Pharmacokinetics of Methotrexate and Its Main Metabolite 7-Hydroxymethotrexate

E. van de Steeg, O. van Tellingen, A. Schinkel, 2011, Drug Metabolism and Disposition.

AFM based elasticity of intestinal epithelium correlate with barrier function under drug action

A. Katan, E. van de Steeg, M. van der Heiden, 2019, bioRxiv.

A higher throughput and physiologically relevant two-compartmental human ex vivo intestinal tissue system for studying gastrointestinal processes.

M. V. van Lipzig, H. Wortelboer, E. van de Steeg, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Down-regulation of OATP1B proteins correlates with hyperbilirubinemia in advanced cholestasis.

V. Lánská, E. van de Steeg, A. Schinkel, 2015, International journal of clinical and experimental pathology.

Gut-on-a-Chip Research for Drug Development: Implications of Chip Design on Preclinical Oral Bioavailability or Intestinal Disease Studies

E. van de Steeg, J. Donkers, Jamie I. van der Vaart, 2023, Biomimetics.

Bcrp1;Mdr1a/b;Mrp2 Combination Knockout Mice: Altered Disposition of the Dietary Carcinogen PhIP (2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine) and Its Genotoxic Metabolites

Tom F. A. de Greef, Jos H. Beijnen, Luc Brunsveld, 2014, Molecular Pharmacology.

Special Section on Pediatric Drug Disposition and Pharmacokinetics Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life

D. Tibboel, H. Wortelboer, E. van de Steeg, 2016 .

Generation of Bayesian prediction models for OATP-mediated drug-drug interactions based on inhibition screen of OATP1B1, OATP1B1∗15 and OATP1B3.

J. Venhorst, H. Wortelboer, E. van de Steeg, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Novel Explanted Human Liver Model to Assess Hepatic Extraction, Biliary Excretion and Transporter Function

E. van de Steeg, B. van Hoek, W. Vaes, 2023, Clinical pharmacology and therapeutics.

The application of organ-on-chip models for the prediction of human pharmacokinetic profiles during drug development.

E. van de Steeg, R. Masereeuw, M. Walles, 2023, Pharmacological research.

PET-CT imaging with [(18)F]-gefitinib to measure Abcb1a/1b (P-gp) and Abcg2 (Bcrp1) mediated drug-drug interactions at the murine blood-brain barrier.

E. van de Steeg, J. DeGroot, C. Sio, 2015, Nuclear medicine and biology.

Evaluation of Normothermic Machine Perfusion of Porcine Livers as a Novel Preclinical Model to Predict Biliary Clearance and Transporter-Mediated Drug-Drug Interactions Using Statins

Andy Z. X. Zhu, E. van de Steeg, W. Vaes, 2021, Drug Metabolism and Disposition.

Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes.

J. Wiśniewski, P. Artursson, H. Wortelboer, 2017, Molecular pharmaceutics.

Methotrexate Pharmacokinetics in Transgenic Mice with Liver-Specific Expression of Human Organic Anion-Transporting Polypeptide 1B1 (SLCO1B1)

E. van de Steeg, A. Schinkel, E. Wagenaar, 2009, Drug Metabolism and Disposition.

Functions of OATP1A and 1B transporters in vivo: insights from mouse models.

E. van de Steeg, A. Schinkel, D. Iusuf, 2012, TIPS - Trends in Pharmacological Sciences.

Intestinal explant barrier chip: long-term intestinal absorption screening in a novel microphysiological system using tissue explants.

E. van de Steeg, I. Bobeldijk, R. Masereeuw, 2021, Lab on a chip.

A host-microbial metabolite interaction gut-on-a-chip model of the adult human intestine demonstrates beneficial effects upon inulin treatment of gut microbiome

E. van de Steeg, J. Donkers, E. Wierenga, 2024, Microbiome research reports.