S. Lira

发表

Overexpression of RelB in transgenic mice does not affect I kappa B alpha levels: differential regulation of RelA and RelB by the inhibitor protein.

F. Weih, R. Bravo, S. Lira, 1996, Oncogene.

Control of microglial neurotoxicity by the fractalkine receptor

Steffen Jung, Jar‐Chi Lee, R. Ransohoff, 2006, Nature Neuroscience.

Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ TH2 cells

S. Lira, A. Luster, I. Charo, 2011, Nature Immunology.

Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques.

F. Tacke, M. Mack, S. Lira, 2007, The Journal of clinical investigation.

Luminal bacteria recruit CD103+ dendritic cells into the intestinal epithelium to sample bacterial antigens for presentation.

S. Lira, Ki-Wook Kim, E. Zigmond, 2013, Immunity.

CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival.

Irving L. Weissman, Christian Weber, Alma Zernecke, 2009, Blood.

Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization

Chen-feng Qi, Qin Li, S. Lira, 2015, Nature Communications.

Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell death

J. Sundberg, S. Lira, Shao-Cong Sun, 2020, bioRxiv.

Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host

Vu Dinh, A. M. Eren, C. Weber, 2018, Nature.

Gut microbiota density influences host physiology and is shaped by host and microbial factors

Judy H. Cho, K. Hao, A. Kasarskis, 2018, bioRxiv.

Overexpression of RelA in Transgenic Mouse Thymocytes : Specific Increase in Levels of the Inhibitor Protein I k B a

R. Bravo, S. Lira, P. Pérez, 1995 .

The Reduced Expression of 6ckine in the plt Mouse Results from the Deletion of One of Two 6ckine Genes

S. Lira, H. Soto, A. Zlotnik, 1999, The Journal of experimental medicine.

Interactions Between Hemopoietically Derived TNF and Central Nervous System-Resident Glial Chemokines Underlie Initiation of Autoimmune Inflammation in the Brain1

S. Lira, R. Hoek, J. Sedgwick, 2002, The Journal of Immunology.

Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis

S. Lira, A. Pletnev, Julia A. Brown, 2017, Journal of Virology.

Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs.

F. Monsma, C. Foster, J. Lachowicz, 2001, The Journal of clinical investigation.

Requirement for the Chemokine Receptor Ccr6 in Allergic Pulmonary Inflammation

S. Lira, D. Cook, N. Lukacs, 2001, The Journal of experimental medicine.

The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics

F. Ginhoux, M. Merad, S. Lira, 2008, Nature Immunology.

Shaping of terminal megakaryocyte differentiation and proplatelet development by sphingosine‐1‐phosphate receptor S1P4

E. Kremmer, S. Lira, K. Bacon, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

Ben D. MacArthur, Avi Ma’ayan, Grigori N. Enikolopov, 2010, Nature.

CCR6 Deficiency Increases Infarct Size after Murine Acute Myocardial Infarction

F. Tacke, J. Jankowski, S. Lira, 2021, Biomedicines.

DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance.

James A. Hutchinson, F. Ginhoux, M. Merad, 2015, Immunity.

Hypoxia stimulates human preproendothelin-1 promoter activity in transgenic mice.

S. Oparil, M. Webb, S. Lira, 1997, American journal of physiology. Lung cellular and molecular physiology.

Chemokines and Kaposi's sarcoma.

K. Jensen, S. Lira, Kristian K. Jensen, 2004, Seminars in cancer biology.

Aberrant in Vivo T Helper Type 2 Cell Response and Impaired Eosinophil Recruitment in Cc Chemokine Receptor 8 Knockout Mice

Tong-Yuan Yang, S. Lira, M. Napolitano, 2001, The Journal of experimental medicine.

Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity.

T. Schwartz, B. Holst, M. Rosenkilde, 2001, The Journal of clinical investigation.

Generation and Analysis of Mice Lacking the Chemokine Fractalkine

S. Lira, L. Sullivan, D. Cook, 2001, Molecular and Cellular Biology.

Impaired Pulmonary Host Defense in Mice Lacking Expression of the CXC Chemokine Lungkine1

T. Standiford, S. Lira, A. Zlotnik, 2001, The Journal of Immunology.

Remission of chronic fungal asthma in the absence of CCR8.

S. Lira, C. Hogaboam, E. Coleman, 2007, The Journal of allergy and clinical immunology.

Murine CXCR1 Is a Functional Receptor for GCP-2/CXCL6 and Interleukin-8/CXCL8*

G. Opdenakker, S. Lira, J. Van Damme, 2007, Journal of Biological Chemistry.

Microglial CX3CR1 promotes adult neurogenesis by inhibiting Sirt 1/p65 signaling independent of CX3CL1

Steffen Jung, M. Prinz, S. Lira, 2016, Acta Neuropathologica Communications.

CXCR2 Desensitization In Vivo Conditional Transgenic Model: Evidence for Disruption of Neutrophil Migration in a

K. Jensen, S. Lira, B. Wilburn, 2001 .

Increased Expression of CCL2 in Insulin-Producing Cells of Transgenic Mice Promotes Mobilization of Myeloid Cells From the Bone Marrow, Marked Insulitis, and Diabetes

S. Lira, S. Rankin, I. Charo, 2008, Diabetes.

The novel compensatory reciprocal interplay between neutrophils and monocytes drives cancer progression

Zhihong Chen, D. Gutmann, K. Lindblad, 2022, bioRxiv.

Brain Initiation of Autoimmune Inflammation in System-Resident Glial Chemokines Underlie Derived TNF and Central Nervous Interactions Between Hemopoietically

S. Lira, R. Hoek, J. Sedgwick, 2002 .

CCL11 (Eotaxin) Induces CCR3-Dependent Smooth Muscle Cell Migration

Christine M. Miller, S. Lira, M. Taubman, 2004, Arteriosclerosis, thrombosis, and vascular biology.

LungkineLacking Expression of the CXC Chemokine Impaired Pulmonary Host Defense in Mice

T. Standiford, S. Lira, A. Zlotnik, 2001 .

Controlled recruitment of monocytes and macrophages to specific organs through transgenic expression of monocyte chemoattractant protein-1.

R. Bravo, S. Lira, M. Fuentes, 1995, Journal of immunology.

The ER-Bound RING Finger Protein 5 (RNF5/RMA1) Causes Degenerative Myopathy in Transgenic Mice and Is Deregulated in Inclusion Body Myositis

Stephen N. Jones, K. Bromberg, Y. Hayashi, 2008, PloS one.

This information is current as Dendritic Cells andEncephalomyelitis Induced by Monocytes A Novel Model of Demyelinating

F. Tacke, R. Ransohoff, S. Lira, 2006 .

A Novel Model of Demyelinating Encephalomyelitis Induced by Monocytes and Dendritic Cells1

F. Tacke, R. Ransohoff, S. Lira, 2006, The Journal of Immunology.

and Tissues of Transgenic Mice Dendritic Cell Subsets in Peripheral Blood Ligand Leads to Expansion of Multiple Conditional Expression of Murine Flt3

K. Jensen, S. Lira, Shu-Cheng Chen, 2003 .

Alloantigen-Specific Foxp3+ Regulatory T Peripheral Development of Lymph Node Occupancy Is Required for the

S. Lira, J. Ochando, Yu Yang, 2013 .

Lymph Node Occupancy Is Required for the Peripheral Development of Alloantigen-Specific Foxp3+ Regulatory T Cells1

S. Lira, A. Garin, J. Ochando, 2005, The Journal of Immunology.

T Foxp3 Alloantigen-Specific Peripheral Development of Lymph Node Occupancy Is Required for the

S. Lira, A. Garin, J. Ochando, 2005 .

Transgenic mice: applications to the study of the nervous system.

L. Swanson, E. Borrelli, R. Evans, 1988, Annual review of neuroscience.

The origin and development of nonlymphoid tissue CD103+ DCs

F. Ginhoux, M. Nussenzweig, M. Merad, 2009, The Journal of experimental medicine.

CX3CR1 Is Expressed by Human B Lymphocytes and Meditates CX3CL1 Driven Chemotaxis of Tonsil Centrocytes

S. Lira, C. Tenca, F. Fais, 2009, PloS one.

Mast Cell–Dependent CD8+ T-cell Recruitment Mediates Immune Surveillance of Intestinal Tumors in ApcMin/+ Mice

A. Mantovani, S. Lira, V. Jala, 2018, Cancer Immunology Research.

Leukocytes expressing green fluorescent protein as novel reagents for adoptive cell transfer and bone marrow transplantation studies.

S. Lira, S. C. Chen, L. Sullivan, 2001, The American journal of pathology.

Transgenic Expression of the Chemokine Receptor Encoded by Human Herpesvirus 8 Induces an Angioproliferative Disease Resembling Kaposi's Sarcoma

Tong-Yuan Yang, M. Leach, S. Lira, 2000, The Journal of experimental medicine.

Lung-specific transgenic expression of KC enhances resistance to Klebsiella pneumoniae in mice.

T. Standiford, M. Burdick, R. Strieter, 1998, Journal of immunology.

Mesenchymal Stem Cells, Regulated by the Sympathetic Nervous System, Form the Hematopoietic Stem Cell Niche

G. Enikolopov, P. Frenette, S. Lira, 2008 .

CCR8 Is Expressed by Antigen-Elicited, IL-10-Producing CD4+CD25+ T Cells, Which Regulate Th2-Mediated Granuloma Formation in Mice1

S. Lira, S. Kunkel, S. Chensue, 2005, The Journal of Immunology.

Impaired lung dendritic cell activation in CCR2 knockout mice.

S. Lira, S. Chensue, I. Charo, 2004, The American journal of pathology.

DC-SIGN + Macrophages C ontrol the Induction of Transplantation Tolerance Graphical

James A. Hutchinson, F. Ginhoux, M. Merad, 2015 .

A Novel Model for Lymphocytic Infiltration of the Thyroid Gland Generated by Transgenic Expression of the CC Chemokine CCL211

P. Frenette, S. Lira, J. Sedgwick, 2004, The Journal of Immunology.

Model of Fungal Allergic Airways Disease Neutrophils Regulate Airway Responses in a

S. Lira, B. Mehrad, Stacy J. Park, 2013 .

Neutrophils Regulate Airway Responses in a Model of Fungal Allergic Airways Disease1

S. Lira, B. Mehrad, Stacy J. Park, 2006, The Journal of Immunology.

CCR 8 Is Expressed by Antigen-Elicited , IL-10-Producing CD 4 CD 25 T Cells , Which Regulate Th 2-Mediated Granuloma Formation in Mice 1

S. Lira, S. Kunkel, S. Chensue, 2005 .

Constitutive Expression of Bcl-3 in Thymocytes Increases the DNA Binding of NF- (cid:107) B1 (p50) Homodimers In Vivo

J. Caamaño, R. Bravo, S. Lira, 1996 .

IFN-γ Determines Distinct Clinical Outcomes in Autoimmune Encephalomyelitis1

Shaohua Chen, D. Zagzag, S. Lira, 2005, The Journal of Immunology.

IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis.

Shaohua Chen, D. Zagzag, S. Lira, 2005, Journal of immunology.

Defective fractalkine‐CX3CR1 signaling aggravates neuroinflammation and affects recovery from cuprizone‐induced demyelination

Chin-Hsing Annie Lin, R. Ransohoff, A. S. Mendiola, 2022, Journal of neurochemistry.

OligodendrocytesExpressing the CC Chemokine CCL21 in Neurological Disease in Transgenic Mice Central Nervous System Inflammation and

M. Leach, S. Lira, A. Zlotnik, 2002 .

A functional role for CCR6 on proallergic T cells in the gastrointestinal tract.

S. Lira, L. Mayer, J. Bromberg, 2010, Gastroenterology.

This information is current as Invasive Pulmonary Aspergillosis Neutrophil-Mediated Host Defense in Necessary Components of CXC Chemokine Receptor-2 Ligands Are

T. Standiford, R. Strieter, T. Moore, 2013 .

CXC chemokine receptor-2 ligands are necessary components of neutrophil-mediated host defense in invasive pulmonary aspergillosis.

T. Standiford, R. Strieter, T. Moore, 1999, Journal of immunology.

The role of CC chemokine receptor 6 in host defense in a model of invasive pulmonary aspergillosis.

S. Lira, B. Mehrad, Stacy J. Park, 2007, American journal of respiratory and critical care medicine.

Tumor and Stem Cell Biology CX 3 CL 1 Promotes Breast Cancer via Transactivation of the EGF Pathway

S. Lira, E. Mira, San-cheng Ma, 2013 .

Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis

G. Bhagat, H. Virgin, Xiaonan Dong, 2016, Proceedings of the National Academy of Sciences.

Controlling Lymphoid Development

S. Lira, G. Furtado, 2016 .

TNFα-dependent development of lymphoid tissue in the absence of RORγt+ Lymphoid Tissue Inducer cells

G. Kollias, J. Caamaño, S. Lira, 2013, Mucosal Immunology.

Chemokine Receptor CCR2 but Not CCR5 or CCR6 Mediates the Increase in Pulmonary Dendritic Cells during Allergic Airway Inflammation1

G. Joos, S. Lira, W. Kuziel, 2007, The Journal of Immunology.

The chemokine receptor D6 has opposing effects on allergic inflammation and airway reactivity.

S. Lira, G. Graham, D. Cook, 2007, American journal of respiratory and critical care medicine.

IFN-γ+ cytotoxic CD4+ T lymphocytes are involved in the pathogenesis of colitis induced by IL-23 and the food colorant Red 40

J. A. Spicer, Jesse D. Gelles, J. Trapani, 2022, Cellular & Molecular Immunology.

The chemokine receptor CCR6 is an important component of the innate immune response

S. Lira, Haitao Wen, S. Kunkel, 2007, European journal of immunology.

The vav proto‐oncogene is required early in embryogenesis but not for hematopoietic development in vitro.

M. Barbacid, A. Bernstein, S. Lira, 1995, The EMBO journal.

Hypoxia stimulates human preproendothelin-1 promoter activity in transgenic mice.

S. Oparil, M. Webb, S. Lira, 1997, The American journal of physiology.

CXCL5 drives neutrophil recruitment in TH17-mediated GN.

S. Kaufmann, U. Panzer, H. Mittrücker, 2015, Journal of the American Society of Nephrology : JASN.

Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts

F. Tacke, R. Jessberger, G. Trinchieri, 2006, Nature Immunology.

Attenuation of TNF-driven murine ileitis by intestinal expression of the viral immunomodulator CrmD

G. Kollias, N. Harpaz, A. Alcamí, 2010, Mucosal Immunology.

CXCL1, but not IL‐6, significantly impacts intraocular inflammation during infection

S. Lira, G. Furtado, M. Callegan, 2016, Journal of leukocyte biology.

CCR7 Deficiency in NOD Mice Leads to Thyroiditis and Primary Hypothyroidism1

S. Lira, Y. Takahama, R. Latif, 2009, The Journal of Immunology.

CCR7 Deficiency in NOD Mice Leads to Thyroiditis and Primary Hypothyroidism1

S. Lira, Y. Takahama, R. Latif, 2009, The Journal of Immunology.

Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene

M. Barbacid, A. Schnapp, Richard J Smeyne, 1994, Nature.

Attenuation of Allergen-Induced Responses in CCR6−/− Mice Is Dependent upon Altered Pulmonary T Lymphocyte Activation

S. Lira, D. Cook, N. Lukacs, 2005, The Journal of Immunology.

Lymphotoxin β receptor signaling is required for inflammatory lymphangiogenesis in the thyroid

M. Skobe, E. Genden, S. Lira, 2007, Proceedings of the National Academy of Sciences.

Interaction of mature CD3+CD4+ T cells with dendritic cells triggers the development of tertiary lymphoid structures in the thyroid.

S. Lira, A. Garin, yang-xin fu, 2006, The Journal of clinical investigation.

Overexpression of RelA in transgenic mouse thymocytes: specific increase in levels of the inhibitor protein I kappa B alpha

R. Bravo, S. Lira, P. Pérez, 1995, Molecular and cellular biology.

A comprehensive murine model to evaluate topical vaginal microbicides: mucosal inflammation and susceptibility to genital herpes as surrogate markers of safety.

Sarah S. Wilson, S. Lira, A. Garin, 2007, The Journal of infectious diseases.

Kaposi's Sarcoma Angioproliferation in a Murine Model of Chemokine Receptor Is Required for The Human Herpes Virus 8-Encoded

K. Jensen, S. Lira, M. Grisotto, 2005 .

Enteric pathogens induce tissue tolerance and prevent neuronal loss from subsequent infections

S. Lira, Begüm Aydin, G. Furtado, 2021, Cell.

T-lymphocyte production of macrophage inflammatory protein-1alpha is critical to the recruitment of CD8(+) T cells to the liver, lung, and spleen during graft-versus-host disease.

J. Serody, S. Lira, B. Blazar, 2000, Blood.

Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation.

Richard D. Gregg, R. Gregg, S. Lira, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Modulation of chemokine activity by viruses.

A. Alcamí, S. Lira, 2010, Current opinion in immunology.

Intratumoral heterogeneity and clonal evolution in liver cancer

Gustavo Stolovitzky, Eric E. Schadt, Bojan Losic, 2020, Nature Communications.

Mice deficient in the CXCR2 ligand, CXCL1 (KC/GRO-α), exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis

M. J. Cody, S. Lira, S. Vogel, 2008, Innate immunity.

Immunopathology and Infectious Disease Impaired Lung Dendritic Cell Activation in CCR 2 Knockout Mice

S. Lira, S. Chensue, I. Charo, 2004 .

Identification of rat growth hormone genomic sequences targeting pituitary expression in transgenic mice.

L. Swanson, C. Glass, M. Rosenfeld, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Discrete cis-active genomic sequences dictate the pituitary cell type-specific expression of rat prolactin and growth hormone genes

R. Evans, M. Rosenfeld, S. Lira, 1986, Nature.

Response and binding elements for ligand-dependent positive transcription factors integrate positive and negative regulation of gene expression.

C. Glass, M. Rosenfeld, S. Lira, 1988, Cold Spring Harbor symposia on quantitative biology.

The role of chemokines in the immunopathology of the liver

S. Lira, S. Kunkel, C. Hogaboam, 2000, Immunological reviews.

Increased responsiveness of murine eosinophils to MIP‐1β (CCL4) and TCA‐3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8

C. Martínez-A, S. Lira, L. Sullivan, 2002, Journal of leukocyte biology.

T Cell Expression of C5a Receptor 2 Augments Murine Regulatory T Cell (TREG) Generation and TREG-Dependent Cardiac Allograft Survival

T. Woodruff, S. Lira, P. Cravedi, 2018, The Journal of Immunology.

A mouse oocyte-specific protein that binds to a region of mZP3 promoter responsible for oocyte-specific mZP3 gene expression

P. Wassarman, S. Lira, R. A. Kinloch, 1992, Molecular and cellular biology.

The Chemokine Binding Protein M3 Prevents Diabetes Induced by Multiple Low Doses of Streptozotocin1

D. Fremont, S. Lira, A. Garin, 2007, The Journal of Immunology.

Lloyd F. Mayer, MD: a remembrance

C. Elson, S. Lira, E. Chang, 2014, Mucosal Immunology.

Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces

S. Lira, H. Yano, D. Artis, 2022, Nature.

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

R. Kastelein, S. Lira, J. Sedgwick, 2003, Nature.

IL-23 activates innate lymphoid cells to promote neonatal intestinal pathology

Axel J. Soto, N. Harpaz, A. Iuga, 2014, Mucosal Immunology.

A Critical Role for Dendritic Cells in the Formation of Lymphatic Vessels within Tertiary Lymphoid Structures

S. Lira, G. Furtado, Luciana R. Muniz, 2011, The Journal of Immunology.

Fractalkine Deficiency Markedly Reduces Macrophage Accumulation and Atherosclerotic Lesion Formation in CCR2 (cid:1) / Mice Evidence for Independent Chemokine Functions in Atherogenesis Coronary Heart Disease

S. Lira, N. Saederup, F. Charo, 2008 .

Expression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine.

M. Merad, A. Alcamí, S. Lira, 2009, Gastroenterology.

CCL20/CCR6 blockade enhances immunity to RSV by impairing recruitment of DC

S. Lira, M. Schaller, N. Lukacs, 2010, European journal of immunology.

Synergistic interactions between Pit-1 and other elements are required for effective somatotroph rat growth hormone gene expression in transgenic mice.

C. Glass, M. Rosenfeld, S. Lira, 1993, Molecular endocrinology.

The chemokine scavenging receptor D6 limits acute toxic liver injury in vivo

F. Tacke, C. Trautwein, S. Lira, 2009, Biological chemistry.

The Chemokine Decoy Receptor M3 Blocks

B. Rollins, S. Lira, L. Shang, 2006 .

CARD9+ Microglia Promote Antifungal Immunity via IL-1β and CXCL1-mediated Neutrophil Recruitment

T. Hohl, S. Lira, Y. Iwakura, 2019, Nature Immunology.

Disruption of CCL21-Induced Chemotaxis In Vitro and In Vivo by M3, a Chemokine-Binding Protein Encoded by Murine Gammaherpesvirus 68

A. Alcamí, K. Jensen, S. Lira, 2003, Journal of Virology.

Constitutively Active Viral Chemokine Receptors: Tools for Immune Subversion and Pathogenesis

S. Lira, M. Smit, D. Détaille, 2010 .

Toll-like receptor signaling in small intestinal epithelium promotes B-cell recruitment and IgA production in lamina propria.

S. Lira, D. Maussang, L. Mayer, 2008, Gastroenterology.

Cutting Edge: The Silent Chemokine Receptor D6 Is Required for Generating T Cell Responses That Mediate Experimental Autoimmune Encephalomyelitis1

R. Ransohoff, S. Lira, Liping Liu, 2006, The Journal of Immunology.

e- Blood In vivo structure/function and expression analysis of the CX 3 C chemokine fractalkine

Steffen Jung, S. Lira, E. Shezen, 2011 .

Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1–infected individuals

H. Ueno, L. Montaner, T. Schacker, 2018, Science Translational Medicine.

Human Cytomegalovirus US28 Facilitates Cell-to-Cell Viral Dissemination

T. Gardner, D. Tortorella, S. Lira, 2014, Viruses.

A passport into the lymph node

S. Lira, 2005, Nature Immunology.

CXCL1 Regulates Pulmonary Host Defense to Klebsiella Infection via CXCL2, CXCL5, NF-κB, and MAPKs

S. Batra, S. Lira, J. Kolls, 2010, The Journal of Immunology.

The biology of chemokines and their receptors

S. Lira, G. Furtado, 2012, Immunologic research.

Inhibition of CCL1-CCR8 Interaction Prevents Aggregation of Macrophages and Development of Peritoneal Adhesions1

S. Lira, A. Matsukawa, A. Hoshino, 2007, The Journal of Immunology.

Ubiquitous Transgenic Expression of the IL-23 Subunit p19 Induces Multiorgan Inflammation, Runting, Infertility, and Premature Death

M. Leach, R. Kastelein, S. Lira, 2001, The Journal of Immunology.

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

B. Engelhardt, F. Sallusto, A. Lanzavecchia, 2009, Nature Immunology.

Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23.

J. Faith, R. DeVita, S. Lira, 2021, Cell metabolism.

Expression of the chemokine N51/KC in the thymus and epidermis of transgenic mice results in marked infiltration of a single class of inflammatory cells

D. Carrasco, R. Bravo, S. Lira, 1994, The Journal of experimental medicine.

Role of CCR8 and Other Chemokine Pathways in the Migration of Monocyte-derived Dendritic Cells to Lymph Nodes

F. Tacke, Steffen Jung, S. Lira, 2004, The Journal of experimental medicine.

The chemokine receptor D6 limits the inflammatory response in vivo

Antonio Alcami, Antal Rot, A. Alcamí, 2005, Nature Immunology.

Absence of CC chemokine receptor 8 enhances innate immunity during septic peritonitis

Takaaki Ito, S. Lira, S. Kunkel, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

CCR6/CCR10-mediated plasmacytoid dendritic cell recruitment to inflamed epithelia after instruction in lymphoid tissues.

J. Blay, G. Trinchieri, C. Caux, 2011, Blood.

CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue.

H. Greenberg, S. Lira, S. Narula, 2000, Immunity.

Transgenic methods to study chemokine function in lung and central nervous system.

R. Strieter, S. Lira, M. Fuentes, 1997, Methods in enzymology.

Neutrophil infiltration, glial reaction, and neurological disease in transgenic mice expressing the chemokine N51/KC in oligodendrocytes.

B. Trapp, J. Peterson, R. Ransohoff, 1996, The Journal of clinical investigation.

Interplay of host microbiota, genetic perturbations, and inflammation promotes local development of intestinal neoplasms in mice

J. Clemente, M. Merad, H. van Bakel, 2014, The Journal of experimental medicine.

Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling

M. Greenberg, R. Ransohoff, M. Nagy, 2019, Nature Neuroscience.

Diet Modifies Colonic Microbiota and CD4+ T-Cell Repertoire to Induce Flares of Colitis in Mice With Myeloid-Cell Expression of Interleukin 23.

R. Sachidanandam, J. Clemente, J. Faith, 2018, Gastroenterology.

PC4/Tis7/IFRD1 Stimulates Skeletal Muscle Regeneration and Is Involved in Myoblast Differentiation as a Regulator of MyoD and NF-κB*

F. Tirone, S. Lira, L. Micheli, 2010, The Journal of Biological Chemistry.

Stress-induced production of chemokines by hair follicles regulates the trafficking of dendritic cells in skin

Keisuke Nagao, Kazuyo Moro, Kouji Matsushima, 2012, Nature Immunology.

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

F. Weih, D. Carrasco, R. Bravo, 1995, Cell.

Chemokine receptor CCR6‐dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis

T. Luedde, F. Tacke, C. Trautwein, 2014, Hepatology.

Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease

Irving L Weissman, Miriam Merad, Petra Hoffmann, 2004, Nature Medicine.

CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation and colitogenic TH17 responses in mice

T. Denning, S. Lira, I. Williams, 2011, The Journal of clinical investigation.

Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs

Boris M. Hartmann, Judy H. Cho, B. Hartmann, 2016, Nature.

Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity

E. Kenigsberg, M. Dubinsky, M. Clatworthy, 2022, Nature Medicine.

Renal agenesis and the absence of enteric neurons in mice lacking GDNF

Jonas Frisén, M. Barbacid, J. Frisén, 1996, Nature.

Microglial CX3CR1 promotes adult neurogenesis by inhibiting Sirt 1/p65 signaling independent of CX3CL1

Steffen Jung, M. Prinz, S. Lira, 2016, Acta neuropathologica communications.

Interleukin 33 regulates gene expression in intestinal epithelial cells independently of its nuclear localization

S. Lira, G. Furtado, Zhengxiang He, 2018, Cytokine.

IL-33 regulates gene expression in intestinal epithelial cells independently of its nuclear localization

S. Lira, G. Furtado, Zhengxiang He, 2018, bioRxiv.

Epithelial-derived IL-33 promotes intestinal tumorigenesis in ApcMin/+ mice

N. Harpaz, S. Lira, G. Bongers, 2017, Scientific Reports.

The human herpesvirus 8 chemokine receptor vGPCR triggers autonomous proliferation of endothelial cells.

S. Sealfon, K. Jensen, S. Lira, 2006, The Journal of clinical investigation.

The Human Herpes Virus 8-Encoded Chemokine Receptor Is Required for Angioproliferation in a Murine Model of Kaposi’s Sarcoma1

T. Schwartz, K. Jensen, S. Lira, 2005, The Journal of Immunology.

Ectopic Expression of the Murine Chemokines CCL21a and CCL21b Induces the Formation of Lymph Node-Like Structures in Pancreas, But Not Skin, of Transgenic Mice

S. Lira, N. Romani, G. Vassileva, 2002, The Journal of Immunology.

Islet Expression of M3 Uncovers a Key Role for Chemokines in the Development and Recruitment of Diabetogenic Cells in NOD Mice

S. Lira, M. Grisotto, S. Kunkel, 2008, Diabetes.

Origin of the lamina propria dendritic cell network.

F. Ginhoux, M. Nussenzweig, M. Merad, 2009, Immunity.

Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1–infected individuals

H. Ueno, L. Montaner, T. Schacker, 2018, Science Translational Medicine.

Intratumoral heterogeneity and clonal evolution in liver cancer

E. Schadt, R. Sebra, G. Stolovitzky, 2020, Nature Communications.

A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans.

N. Harpaz, A. Iuga, E. Reddy, 2012, Gastroenterology.

Mice deficient for CCR6 fail to control chronic experimental autoimmune encephalomyelitis

S. Lira, W. Karpus, N. Lukacs, 2009, Journal of Neuroimmunology.

Transcriptional and post-transcriptional strategies in neuroendocrine gene expression.

S. Leff, R. Emeson, M. Rosenfeld, 1988, Developmental biology.

Developmental and hormonal regulation of neuroendocrine gene transcription.

M. Rosenfeld, M. Waterman, S. Lira, 1987, Recent progress in hormone research.

CXCL13 expression in the gut promotes accumulation of IL-22-producing lymphoid tissue-inducer cells, and formation of isolated lymphoid follicles

S. Lira, M. Grisotto, L. Mayer, 2009, Mucosal Immunology.

In vivo structure/function and expression analysis of the CX3C chemokine fractalkine.

Steffen Jung, S. Lira, E. Shezen, 2011, Blood.

CX3CL1 promotes breast cancer via transactivation of the EGF pathway.

S. Lira, Í. Azcoitia, S. Mañes, 2013, Cancer research.

Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus.

Steffen Jung, M. Schwartz, P. Bendel, 2013, Immunity.

EGFR/Ras-induced CCL20 production modulates the tumour microenvironment

J. Sleeman, J. Fischer, N. Stoecklein, 2020, British Journal of Cancer.

Expression of a Novel Murine Type I IFN in the Pancreatic Islets Induces Diabetes in Mice1

K. Jensen, S. Lira, Ming Zeng, 2003, The Journal of Immunology.

Fractalkine Deficiency Markedly Reduces Macrophage Accumulation and Atherosclerotic Lesion Formation in CCR2−/− Mice: Evidence for Independent Chemokine Functions in Atherogenesis

S. Lira, I. Charo, N. Saederup, 2008, Circulation.

Constitutive expression of Bc1-3 in thymocytes increases the DNA binding of NF-kappaB1 (p50) homodimers in vivo

J. Caamaño, R. Bravo, S. Lira, 1996, Molecular and cellular biology.

cis‐Acting DNA elements involved in oocyte‐specific expression of mouse sperm receptor gene mZP3 are located close to the gene's transcription start site

S. Lira, M. Schickler, Michael Schickler, 1993, Molecular reproduction and development.

An upstream region of the mouse ZP3 gene directs expression of firefly luciferase specifically to growing oocytes in transgenic mice.

P. Wassarman, S. Lira, R. A. Kinloch, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo.

J. Sirard, C. Caux, S. Lira, 2006, Immunity.

CARD9+ Microglia Promote Antifungal Immunity via IL-1β and CXCL1-mediated Neutrophil Recruitment

T. Hohl, S. Lira, Y. Iwakura, 2019, Nature Immunology.

Interleukin-33 Induces the Enzyme Tryptophan Hydroxylase 1 to Promote Inflammatory Group 2 Innate Lymphoid Cell-Mediated Immunity.

J. B. Moeller, G. Karsenty, S. Lira, 2020, Immunity.

Disruption of the erp/mkp-1 gene does not affect mouse development: normal MAP kinase activity in ERP/MKP-1-deficient fibroblasts.

D. Carrasco, D. Carrasco, R. Bravo, 1996, Oncogene.

Tumor-Infiltrating Regulatory T-cell Accumulation in the Tumor Microenvironment Is Mediated by IL33/ST2 Signaling

Insuk Lee, S. Ha, C. Choi, 2020, Cancer Immunology Research.

TLR4 Activates the β-catenin Pathway to Cause Intestinal Neoplasia

Mansoor M Ahmed, S. Lira, P. Bejarano, 2013, PloS one.

HCMV-Encoded Chemokine Receptor US28 Mediates Proliferative Signaling Through the IL-6–STAT3 Axis

Marco Siderius, Cecilia Söderberg-Nauclér, A. Schreiber, 2010, Science Signaling.

BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups

M. Merad, S. Lira, M. Manz, 2014, The Journal of experimental medicine.

CNS Langerhans cell histiocytosis: Common hematopoietic origin for LCH‐associated neurodegeneration and mass lesions

J. Quinn, M. Merad, C. Rodríguez-Galindo, 2018, Cancer.

Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements

M. Barbacid, Richard J Smeyne, R. Klein, 1994, Nature.

BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups

M. Merad, S. Lira, M. Manz, 2015, The Journal of experimental medicine.

Inhibition of intimal hyperplasia in transgenic mice conditionally expressing the chemokine-binding protein M3.

A. Alcamí, K. Jensen, S. Lira, 2004, The American journal of pathology.

The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice.

R. Leurs, H. Clevers, N. Harpaz, 2010, The Journal of clinical investigation.

The Chemokine Decoy Receptor M3 Blocks CC Chemokine Ligand 2 and CXC Chemokine Ligand 13 Function In Vivo1

B. Rollins, S. Lira, L. Shang, 2006, The Journal of Immunology.

Conditional transgenic models to study chemokine biology.

K. Jensen, S. Lira, G. Vassileva, 2004, Methods in molecular biology.

Genetic Models to Study Chemokine Biology in the Lung

T. Standiford, S. Lira, S. Chensue, 2003 .

Transgenic Mice Structures in Pancreas , But Not Skin , of the Formation of Lymph Node-Like Chemokines CCL 21 a and CCL 21 b Induces Ectopic Expression of the Murine Romani

S. Lira, N. Romani, G. Vassileva, 2002 .

Disruption of Neutrophil Migration in a Conditional Transgenic Model: Evidence for CXCR2 Desensitization In Vivo

K. Jensen, S. Lira, B. Wilburn, 2001, The Journal of Immunology.

Up-regulated expression of the CXCR2 ligand KC/GRO-alpha in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progression.

R. Terkeltaub, S. Lira, M. Fuentes, 2006, The American journal of pathology.

CD4+ CD25+ regulatory T-cells inhibit the islet innate immune response and promote islet engraftment.

N. Zhang, S. Fu, S. Lira, 2006, Diabetes.

CCR8+FOXp3+ Treg cells as master drivers of immune regulation

S. Lira, Yiftah Barsheshet, N. Karin, 2017, Proceedings of the National Academy of Sciences.

CCR8 is expressed by post-positive selection CD4-lineage thymocytes but is dispensable for central tolerance induction

S. Lira, L. Ehrlich, J. Lancaster, 2018, PloS one.

T-lymphocyte production of macrophage inflammatory protein-1α is critical to the recruitment of CD8+ T cells to the liver, lung, and spleen during graft-versus-host disease

J. Serody, S. Lira, B. Blazar, 2000 .

Dynamic regulation of B cell Complement Signaling is Integral to Germinal Center Responses

S. Lira, G. Varano, P. Heeger, 2021, Nature Immunology.

Characterization of candidate genes in inflammatory bowel disease-associated risk loci.

Hailiang Huang, Lingjia Kong, Talin Haritunians, 2016, JCI insight.

The chemokine-binding protein M3 as a tool to understand the chemokine network in vivo.

S. Lira, L. Shang, Andrea P Martin, 2009, Methods in Enzymology.

Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation

Qingshan Li, Chen-feng Qi, M. Shin, 2011, Nature communications.

Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23

J. Faith, S. Lira, S. Durum, 2019, Nature Communications.

Interleukin 22 mediates interleukin 23-induced pathology in newborn mice by disrupting the function of pancreatic and intestinal cells

J. Faith, S. Lira, S. Durum, 2018, bioRxiv.

Conditional Expression of Murine Flt3 Ligand Leads to Expansion of Multiple Dendritic Cell Subsets in Peripheral Blood and Tissues of Transgenic Mice1

K. Jensen, S. Lira, Shu-Cheng Chen, 2003, The Journal of Immunology.

Tissues of Transgenic Mice Dendritic Cell Subsets in Peripheral Blood Ligand Leads to Expansion of Multiple Conditional Expression of Murine Flt 3

K. Jensen, S. Lira, Shu-Cheng Chen, 2003 .

Central Nervous System Inflammation and Neurological Disease in Transgenic Mice Expressing the CC Chemokine CCL21 in Oligodendrocytes

M. Leach, S. Lira, A. Zlotnik, 2002, The Journal of Immunology.

Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis‐associated tumorigenesis

N. Harpaz, H. Cooper, S. Lira, 2011, Inflammatory Bowel Diseases.

Skin expression of IL-23 drives the development of psoriasis and psoriatic arthritis in mice

S. Lira, M. Grisotto, P. Gulko, 2020, Scientific Reports.

Transcription Factor IRF 8 Directs a Silencing Programme for TH 17 Cell Differentiation

Qingshan Li, Chen-feng Qi, M. Shin, 2011 .

Immunopathology and Infectious Diseases Neuroprotection and Remyelination after Autoimmune Demyelination in Mice that Inducibly Overexpress CXCL 1

L. Santambrogio, S. Lira, C. Raine, 2010 .

Hepatic macrophage migration and differentiation critical for liver fibrosis is mediated by the chemokine receptor C‐C motif chemokine receptor 8 in mice

T. Luedde, F. Tacke, C. Trautwein, 2012, Hepatology.

Interleukin 1 beta and Matrix Metallopeptidase 3 Contribute to Development of EGFR-dependent Serrated Polyps in Mouse Cecum.

S. Lira, G. Bongers, G. Furtado, 2019, Gastroenterology.

CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function

F. Tacke, K. Okkenhaug, A. Liston, 2021, Immunology.

Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer

T. Luedde, F. Tacke, C. Trautwein, 2012, Gut.

Diet Modifies Colonic Microbiota and CD4+ T Cell Repertoire to Trigger Flares in a Novel Model of Colitis Induced by IL-23

R. Sachidanandam, J. Clemente, J. Faith, 2018, bioRxiv.

Fractalkine Signaling Attenuates Perivascular Clustering of Microglia and Fibrinogen Leakage during Systemic Inflammation in Mouse Models of Diabetic Retinopathy

K. Akassoglou, S. Lira, A. Cardona, 2017, Front. Cell. Neurosci..

Increased inflammation in mice deficient for the chemokine decoy receptor D6

Alberto Mantovani, A. Mantovani, S. Lira, 2005, European journal of immunology.

BRAF-V600E in Peripheral Mononuclear Cells and Microglia-like Brain Cells Suggest Hematopoietic Origin of Langerhans Cell Histiocytosis-Associated Neurodegeneration

J. Quinn, M. Merad, C. Rodríguez-Galindo, 2017 .

CC Chemokine Ligand 18 in ANCA-Associated Crescentic GN.

F. Tacke, U. Panzer, S. Lira, 2015, Journal of the American Society of Nephrology : JASN.

Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6

A. Mantovani, S. Lira, B. Haribabu, 2007, Proceedings of the National Academy of Sciences.

in Mice Klebsiella pneumoniae Enhances Resistance to Lung-Specific Transgenic Expression of KC

M. Burdick, R. Strieter, S. Lira, 1998 .

Genetic approaches to study chemokine function

S. Lira, 1996, Journal of leukocyte biology.

Monocyte depletion enhances neutrophil influx and proneural to mesenchymal transition in glioblastoma

Zhihong Chen, D. Gutmann, K. Lindblad, 2023, Nature Communications.

Autoimmune Encephalomyelitis Cell Responses That Mediate Experimental Receptor D6 Is Required for Generating T Cutting Edge: The Silent Chemokine

S. Lira, G. Graham, Margaret E. Sasse, 2022 .

The biology of chemokines and their receptors

S. Lira, G. Furtado, 2012, Immunologic Research.

Microglial CX3CR1I249/M280 variant limits neurogenesis and remyelination in cuprizone-induced multiple sclerosis model

Chin-Hsing Annie Lin, R. Ransohoff, S. Lira, 2021, bioRxiv.

The myeloperoxidase gene proximal enhancer directs hematopoietic-specific expression in transgenic mice.

S. Lira, A. Friedman, 1997, Gene.

Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn’s disease and leads to impaired CFB cleavage and phagocytosis

Judy H. Cho, Alka A. Potdar, J. Rioux, 2023, Gut.

Neuronal Expression of chimeric genes in transgenic mice

L. Swanson, M. Rosenfeld, S. Lira, 1988, Neuron.

Spleen plays a major role in DLL4-driven acute T-cell lymphoblastic leukemia

Hossein Khiabanian, D. Herranz, G. Gómez-López, 2021, Theranostics.

The Reduced Expression of 6 Ckine in the plt Mouse Results from the Deletion of One of Two 6 Ckine Genes

S. Lira, H. Soto, A. Zlotnik, 1999 .

Expression of FosB during mouse development: normal development of FosB knockout mice.

S K Durham, R. Bravo, S. Lira, 1996, Oncogene.

O-002 Genes in IBD-Associated Risk Loci Demonstrate Genotype-, Tissue-, and Inflammation-Specific Patterns of Expression in Terminal Ileum and Colon Mucosal Tissue

M. Daly, R. Xavier, D. McGovern, 2016, Inflammatory Bowel Diseases.

Transient lung-specific expression of the chemokine KC improves outcome in invasive aspergillosis.

S. Lira, B. Morrison, Shu-Cheng Chen, 2002, American journal of respiratory and critical care medicine.

Epithelial-derived IL-33 promotes intestinal tumorigenesis in ApcMin/+ mice

N. Harpaz, S. Lira, G. Bongers, 2017, Scientific Reports.

Tachykinin NK3-receptor deficiency does not inhibit pulmonary eosinophilia in allergic mice.

R. Egan, S. Lira, S. Greenfeder, 2004, Pharmacological research.