C. Haigh

发表

Regulation of prion protein expression by noncoding regions of the Prnp gene.

C. Haigh, Josephine A. Wright, David R. Brown, 2007, Journal of molecular biology.

Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids

J. A. Carroll, C. Haigh, B. Race, 2019, Acta Neuropathologica Communications.

Copper binding is the governing determinant of prion protein turnover

C. Haigh, David R. Brown, K. Edwards, 2005, Molecular and Cellular Neuroscience.

Reduced SOD2 expression does not influence prion disease course or pathology in mice

C. Haigh, B. Race, B. Groveman, 2021, PloS one.

Cytosolic caspases mediate mislocalised SOD2 depletion in an in vitro model of chronic prion infection

C. Haigh, V. Lewis, S. Collins, 2013, Disease Models & Mechanisms.

Organoids for modeling prion diseases

C. Haigh, Ryan O Walters, Ryan O. Walters, 2022, Cell and Tissue Research.

Copper, endoproteolytic processing of the prion protein and cell signalling.

C. Haigh, Shaike Marom, S. Collins, 2010, Frontiers in bioscience.

Acute exposure to prion infection induces transient oxidative stress progressing to be cumulatively deleterious with chronic propagation in vitro.

C. Masters, C. Haigh, A. McGlade, 2011, Free radical biology & medicine.

A 3D cell culture approach for studying neuroinflammation

J. A. Carroll, C. Haigh, S. Foliaki, 2021, Journal of Neuroscience Methods.

Development of a neuroprotective antioxidant by a mix-and-match strategy -

C. Haigh, K. Barnham, S. Collins, 2013 .

A Functional Role for Aβ in Metal Homeostasis? N-Truncation and High-Affinity Copper Binding.

Urszula E. Wawrzyniak, C. Haigh, W. Bal, 2015, Angewandte Chemie.

Cavitation during the protein misfolding cyclic amplification (PMCA) method--The trigger for de novo prion generation?

C. Haigh, S. Drew, 2015, Biochemical and biophysical research communications.

Pathogenic Prion Protein Isoforms Are Not Present in Cerebral Organoids Generated from Asymptomatic Donors Carrying the E200K Mutation Associated with Familial Prion Disease

P. Tesar, C. Haigh, B. Groveman, 2020, Pathogens.

Rottlerin inhibits La Crosse virus-induced encephalitis in mice and blocks release of replicating virus from the Golgi body in neurons

Catherine Z. Chen, Wei Zheng, C. Haigh, 2021, Nature Microbiology.

Human cerebral organoids as a therapeutic drug screening model for Creutzfeldt–Jakob disease

C. Haigh, B. Race, B. Groveman, 2021, Scientific Reports.

Near-infrared fluorescence imaging of apoptotic neuronal cell death in a live animal model of prion disease.

C. Masters, C. Haigh, B. Roberts, 2010, ACS chemical neuroscience.

Neutron reflectometry studies define prion protein N-terminal peptide membrane binding.

C. Haigh, Martin P Boland, S. Collins, 2014, Biophysical journal.

Microwave Synthesis of Prion Protein Fragments up to 111 Amino Acids in Length Generates Biologically Active Peptides

A. Hill, C. Haigh, J. Karas, 2011, International Journal of Peptide Research and Therapeutics.

C. Masters, A. Hill, C. Haigh, 2009, Cell Research.

Prion protein reduces both oxidative and non‐oxidative copper toxicity

C. Haigh, David R. Brown, 2006, Journal of neurochemistry.

Blood vessel cell death during prion disease: implications for disease management and infection control.

C. Haigh, V. Lawson, S. Drew, 2014, Experimental hematology.

Prion protein N1 cleavage peptides stimulate microglial interaction with surrounding cells

J. A. Carroll, C. Haigh, B. Race, 2020, Scientific Reports.

Copper‐dependent co‐internalization of the prion protein and glypican‐1

C. Haigh, David R. Brown, K. Mani, 2006, Journal of neurochemistry.

A 2-Substituted 8-Hydroxyquinoline Stimulates Neural Stem Cell Proliferation by Modulating ROS Signalling

C. Haigh, S. Collins, S. Drew, 2016, Cell Biochemistry and Biophysics.

Hereditary E200K mutation within the prion protein gene alters human iPSC derived cardiomyocyte function

C. Haigh, B. Groveman, S. Foliaki, 2022, Scientific Reports.

Prion protein cleavage fragments regulate adult neural stem cell quiescence through redox modulation of mitochondrial fission and SOD2 expression

C. Haigh, S. Collins, B. Groveman, 2018, Cellular and Molecular Life Sciences.

Cellular Analysis of Adult Neural Stem Cells for Investigating Prion Biology.

C. Haigh, 2017, Methods in molecular biology.

Simplified Murine 3D Neuronal Cultures for Investigating Neuronal Activity and Neurodegeneration

C. Haigh, S. Collins, 2017, Cell Biochemistry and Biophysics.

Endoproteolytic cleavage as a molecular switch regulating and diversifying prion protein function

C. Haigh, S. Collins, 2016, Neural regeneration research.

MEK1 transduces the prion protein N2 fragment antioxidant effects

C. Haigh, S. Collins, A. McGlade, 2014, Cellular and Molecular Life Sciences.

Stress and viral insults do not trigger E200K PrP conversion in human cerebral organoids

C. Haigh, K. Peterson, B. Groveman, 2022, PloS one.

MEK1 transduces the prion protein N2 fragment antioxidant effects

C. Haigh, A. McGlade, S. Collins, 2015, Cellular and Molecular Life Sciences.

Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response

C. Masters, C. Haigh, Martin P Boland, 2009, Journal of Cell Science.

Increased Proportions of C1 Truncated Prion Protein Protect Against Cellular M1000 Prion Infection

C. Masters, A. Hill, C. Haigh, 2009, Journal of neuropathology and experimental neurology.

The prion protein regulates beta-amyloid-mediated self-renewal of neural stem cells in vitro

Qiao-Xin Li, C. Haigh, T. Ryan, 2015, Stem Cell Research & Therapy.

Neuronal maturation reduces the type I IFN response to orthobunyavirus infection and leads to increased apoptosis of human neurons

C. Haigh, C. Martens, A. Carmody, 2019, Journal of Neuroinflammation.

Anionic Phospholipid Interactions of the Prion Protein N Terminus Are Minimally Perturbing and Not Driven Solely by the Octapeptide Repeat Domain*

C. Masters, A. Hill, D. Tew, 2010, The Journal of Biological Chemistry.

Regulation of prion protein expression and cellular activity

Cathryn Louise Haigh, C. Haigh, 2006 .

Regulation of Prion Protein Expression: A Potential Site for Therapeutic Intervention in the Transmissible Spongiform Encephalopathies

C. Haigh, D. Brown, 2006, International journal of biomedical science : IJBS.

Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPres level disparity

C. Masters, A. Hill, C. Haigh, 2012, Molecular Neurodegeneration.

Sporadic Creutzfeldt–Jakob disease infected human cerebral organoids retain the original human brain subtype features following transmission to humanized transgenic mice

C. Haigh, B. Race, B. Groveman, 2023, Acta Neuropathologica Communications.

Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids

J. A. Carroll, C. Haigh, B. Race, 2019, Acta Neuropathologica Communications.

Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases

J. A. Carroll, C. Haigh, B. Groveman, 2021, Molecular brain.

Altered energy metabolism in Fatal Familial Insomnia cerebral organoids is associated with astrogliosis and neuronal dysfunction

C. Haigh, B. Groveman, S. Foliaki, 2023, PLoS genetics.

The Prion Protein N1 and N2 Cleavage Fragments Bind to Phosphatidylserine and Phosphatidic Acid; Relevance to Stress-Protection Responses

C. Haigh, S. Collins, S. Drew, 2015, PloS one.

Cerebral organoids as a new model for prion disease

C. Haigh, B. Groveman, K. Williams, 2021, PLoS pathogens.

Using our mini-brains: cerebral organoids as an improved cellular model for human prion disease

C. Haigh, B. Groveman, Ryan O. Walters, 2019, Neural regeneration research.

Electrophysiological Investigations of Prion Protein Roles in Health and Disease

C. Haigh, B. Groveman, S. Foliaki, 2019, Neurodegenerative Diseases - Molecular Mechanisms and Current Therapeutic Approaches.

Optical Imaging Detects Apoptosis in the Brain and Peripheral Organs of Prion-Infected Mice

C. Masters, C. Haigh, K. Barnham, 2011, Journal of neuropathology and experimental neurology.

Temporary alteration of neuronal network communication is a protective response to redox imbalance that requires GPI-anchored prion protein

C. Haigh, B. Groveman, S. Foliaki, 2023, Redox biology.

Microwave Synthesis of Prion Protein Fragments up to 111 Amino Acids in Length Generates Biologically Active Peptides

A. Hill, C. Haigh, J. Karas, 2012, International Journal of Peptide Research and Therapeutics.

Investigation of PrPC metabolism and function in live cells : methods for studying individual cells and cell populations.

C. Haigh, David R. Brown, 2008, Methods in molecular biology.

α-Synuclein seeding activity in duodenum biopsies from Parkinson’s disease patients

B. Caughey, G. Cossu, C. Haigh, 2023, PLoS pathogens.

Nosing around α-synuclein

C. Haigh, 2019, Science Translational Medicine.

Prion protein N1 cleavage peptides stimulate microglial interaction with surrounding cells

J. A. Carroll, C. Haigh, B. Race, 2020, Scientific Reports.

The lymphatic route of TAU

C. Haigh, 2019, Science Translational Medicine.

In Vivo-Near Infrared Imaging of Neurodegeneration.

C. Haigh, V. Lawson, S. Drew, 2017, Methods in molecular biology.

Increased Proportions of C1 Truncated Prion Protein Protect Against Cellular M1000 Prion Infection

C. Masters, A. Hill, C. Haigh, 2009, Journal of neuropathology and experimental neurology.

A PrP EGFR signaling axis controls neural stem cell senescence through modulating cellular energy pathways

C. Haigh, B. Groveman, S. Foliaki, 2023, The Journal of biological chemistry.

Doubling-down on prion protein function in Alzheimer’s disease

C. Haigh, 2019, Science Translational Medicine.

Lack of Transmission of Chronic Wasting Disease Prions to Human Cerebral Organoids.

C. Haigh, B. Groveman, S. Foliaki, 2024, Emerging infectious diseases.

Prion propagation and cellular dysfunction in prion disease: Disconnecting the dots

C. Haigh, S. Foliaki, 2023, PLoS pathogens.

Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases

R. Nonno, C. Haigh, M. Damme, 2023, bioRxiv.