G. Molema

Grietje Molema, E. Middelkoop, G. Molema, 2011, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

Cellular Handling of a Dexamethasone-Anti-E-Selectin Immunoconjugate by Activated Endothelial Cells: Comparison with Free Dexamethasone

G. Molema, M. Everts, R. Kok, 2002, Pharmaceutical Research.

Targeting of angiogenic endothelial cells at sites of inflammation by dexamethasone phosphate-containing RGD peptide liposomes inhibits experimental arthritis.

M. Wauben, R. Schiffelers, G. Molema, 2006, Arthritis and rheumatism.

Targeted adenovirus mediated inhibition of NF-κB-dependent inflammatory gene expression in endothelial cells in vitro and in vivo.

M. Rots, C. Trautwein, B. Banas, 2013, Journal of controlled release : official journal of the Controlled Release Society.

3. Tumor vessel biology in pediatric intracranial ependymoma

G. Molema, 2018 .

Tumor vessel biology in pediatric intracranial ependymoma.

W. D. den Dunnen, G. Molema, E. Hoving, 2010, Journal of neurosurgery. Pediatrics.

Chemokine production and E-selectin expression in activated endothelial cells are inhibited by p38 MAPK (mitogen activated protein kinase) inhibitor RWJ 67657.

P. Limburg, G. Molema, J. Kuldo, 2005, International immunopharmacology.

aged erythrocytes and apoptotic cells Angiogenic endothelium shows lactadherin-dependent phagocytosis of

R. Schiffelers, G. Molema, E. Mastrobattista, 2009 .

Angiogenic endothelium shows lactadherin-dependent phagocytosis of aged erythrocytes and apoptotic cells.

R. Schiffelers, G. Molema, G. Storm, 2008, Blood.

University of Groningen A role of stochastic phenotype switching in generating mosaic endothelial cell

Lei Yuan, P. Kang, W. J. Adams, 2017 .

Targeting of naproxen covalently linked to HSA to sinusoidal cell types of the liver.

C. Lebbé, C. Albrecht, G. Molema, 1998, Journal of drug targeting.

DONOR BRAIN DEATH REDUCES SURVIVAL AFTER TRANSPLANTATION IN RAT LIVERS PRESERVED FOR 20 HR1

G. Molema, G. T. ter Horst, R. Ploeg, 2001, Transplantation.

RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG.

Amber N. Stratman, Lei Yuan, M. Bhasin, 2011, Blood.

Transfection mediated by pH-sensitive sugar-based gemini surfactants; potential for in vivo gene therapy applications

G. Molema, D. Hoekstra, J. Engberts, 2006, Journal of Molecular Medicine.

Synergy of bovine lactoferrin with the anti-cytomegalovirus drug cidofovir in vitro.

M. Harmsen, G. Molema, D. Meijer, 2003, Antiviral research.

Selective Intracellular Delivery of Dexamethasone into Activated Endothelial Cells Using an E-Selectin-Directed Immunoconjugate

G. Molema, M. Everts, G. Koning, 2002, The Journal of Immunology.

Design , Synthesis , and Biological Evaluation of a Dual Tumor-specific Motive Containing Integrin-targeted Plasmin-cleavable Doxorubicin Prodrug 1

H. W. Scheeren, G. Molema, R. Kok, 2002 .

Drug targeting systems for antiviral agents: options and limitations.

G. Molema, D. Meijer, R. Jansen, 1992, Antiviral research.

A critical role for Egr-1 during vascular remodelling in pulmonary arterial hypertension.

J. Kamps, G. Molema, Piotr S. Kowalski, 2014, Cardiovascular research.

Hyperglycaemic memory affects the neurovascular unit of the retina in a diabetic mouse model

H. Hammes, G. Molema, C. Sticht, 2017, Diabetologia.

Pericyte migration : A novel mechanism of pericyte loss in experimental diabetic retinopathy

H. Hammes, G. Molema, J. Hillebrands, 2008 .

Pleiotropic effects of angiopoietin-2 deficiency do not protect mice against endotoxin-induced acute kidney injury.

M. van Meurs, H. Hammes, M. Struys, 2013, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Time course of angiopoietin-2 release during experimental human endotoxemia and sepsis

M. van Meurs, G. Molema, J. Zijlstra, 2009, Critical care.

The effect of surgical wounding on tumour development.

H. Hoekstra, H. Wanebo, G. Molema, 1999, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

University of Groningen Time course of angiopoietin-2 release during experimental human endotoxemia and sepsis Kümpers,

G. Molema, J. Zijlstra, M. Meurs, 2015 .

Vascular bed-specific regulation of the von Willebrand factor promoter in the heart and skeletal muscle.

Lei Yuan, P. Oettgen, W. Aird, 2011, Blood.

Beneficial Effects of an Alternating High- Fat Dietary Regimen on Systemic Insulin Resistance, Hepatic and Renal Inflammation and Renal Function

T. Kooistra, R. Kleemann, G. Molema, 2012, PloS one.

Angiogenic transcriptome of human microvascular endothelial cells: Effect of hypoxia, modulation by atorvastatin.

G. Molema, A. Józkowicz, J. Dulak, 2006, Vascular pharmacology.

Neovascularization and vascular markers in a foreign body reaction to subcutaneously implanted degradable biomaterial in mice

G. Molema, H. Moorlag, M. V. van Luyn, 2004, Angiogenesis.

Functional inhibition of NF-kappa B signal transduction in alpha v alpha beta 3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant I kappa B

M. Rots, C. Trautwein, B. Kroesen, 2018 .

University of Groningen Functional inhibition of NF-kappa B signal transduction in alpha v alpha beta 3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant I kappa B gene Ogawara,

M. Rots, C. Trautwein, B. Kroesen, 2015 .

Functional inhibition of NF-κB signal transduction in αvβ3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IκB gene

M. Rots, C. Trautwein, B. Kroesen, 2006, Arthritis research & therapy.

Unlocking the Untapped Potential of Endothelial Kinase and Phosphatase Involvement in Sepsis for Drug Treatment Design

M. van Meurs, G. Molema, M. Luxen, 2022, Frontiers in Immunology.

Reply to letter: "Markers of angiogenesis in synchronous and in metachronous colorectal hepatic metastases".

J. Kamps, G. Molema, H. Moorlag, 2015, Annals of surgery.

Hemorrhagic Shock-induced Endothelial Cell Activation in a Spontaneous Breathing and a Mechanical Ventilation Hemorrhagic Shock Model Is Induced by a Proinflammatory Response and Not by Hypoxia

M. van Meurs, G. Molema, J. Zijlstra, 2011, Anesthesiology.

Tumor vasculature targeted therapies: getting the players organized.

G. Molema, D. Meijer, L. D. de Leij, 1998, Biochemical pharmacology.

The in vivo endothelial cell translatome is highly heterogeneous across vascular beds

W. Aird, S. Ganesh, G. Molema, 2019, Proceedings of the National Academy of Sciences.

COX-2 Inhibition Combined with Radiation Reduces Orthotopic Glioma Outgrowth by Targeting the Tumor Vasculature.

G. Molema, H. Moorlag, M. Wagemakers, 2009, Translational oncology.

The use of bispecific antibodies in tumor cell and tumor vasculature directed immunotherapy.

B. Kroesen, G. Molema, D. Meijer, 2000, Journal of controlled release : official journal of the Controlled Release Society.

In vivo evaluation of RGD-albumin constructs as carriers for small molecule drugs

G. Molema, R. Kok, L. Beljaars, 2007 .

Peptide-targeted PEG-liposomes in anti-angiogenic therapy.

R. Schiffelers, G. Molema, G. Koning, 2003, International journal of pharmaceutics.

RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature.

R. Schiffelers, G. Molema, R. Kok, 2005, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Molecular characterization of the vascular features of focal nodular hyperplasia and hepatocellular adenoma: A role for angiopoietin‐1

S. Poppema, G. Molema, Wenjiao Zeng, 2010, Hepatology.

Local Medial Microenvironment Directs Phenotypic Modulation of Smooth Muscle Cells After Experimental Renal Transplantation

Kiran K. Katta, G. Navis, R. Goldschmeding, 2012, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Endothelium in vitro: A review of human vascular endothelial cell lines for blood vessel-related research

G. Hospers, N. Mulder, Diane Bouïs, 2004, Angiogenesis.

Adiponectin Diminishes Organ-Specific Microvascular Endothelial Cell Activation Associated With Sepsis

M. van Meurs, T. Funahashi, W. Aird, 2012, Shock.

Hepatic endocytosis of various types of mannose-terminated albumins. What is important, sugar recognition, net charge, or the combination of these features.

G. Molema, D. Meijer, G. Harms, 1990, The Journal of biological chemistry.

Adjunct Nitrous Oxide Normalizes Vascular Reactivity Changes after Hemorrhagic Shock in Mice under Isoflurane Anesthesia

M. van Meurs, R. Henning, G. Molema, 2009, Anesthesiology.

Liposome-encapsulated prednisolone phosphate inhibits growth of established tumors in mice.

R. Schiffelers, G. Molema, G. Storm, 2005, Neoplasia.

LIPOSOME-ENCAPSULATED PREDNISOLONE PHOSPHATE INHIBITS TUMOR GROWTH IN MICE

R. Schiffelers, G. Molema, G. Storm, 2003 .

Improved efficacy of αvβ3-targeted albumin conjugates by conjugation of a novel auristatin derivative

G. Molema, R. Kok, P. Senter, 2007 .

VCAM-1 specific PEGylated SAINT-based lipoplexes deliver siRNA to activated endothelium in vivo but do not attenuate target gene expression.

J. Kamps, G. Molema, P. Zwiers, 2014, International journal of pharmaceutics.

Signalling or binding: the role of the platelet‐activating factor receptor in invasive pneumococcal disease

G. Molema, J. Bijlsma, M. Brouwer, 2013, Cellular microbiology.

Atorvastatin prevents hypoxia-induced inhibition of endothelial nitric oxide synthase expression but does not affect heme oxygenase-1 in human microvascular endothelial cells.

G. Molema, J. Dorosz, A. Józkowicz, 2006, Atherosclerosis.

Egr-1 expression during neointimal development in flow-associated pulmonary hypertension.

G. Molema, H. Sietsma, R. Berger, 2011, The American journal of pathology.

The absence of angiopoietin-2 leads to abnormal vascular maturation and persistent proliferative retinopathy

S. Beck, M. Seeliger, H. Hammes, 2009, Thrombosis and Haemostasis.

Intracellular RIG-I Signaling Regulates TLR4-Independent Endothelial Inflammatory Responses to Endotoxin

M. van Meurs, W. Aird, I. A. D. de Graaf, 2016, The Journal of Immunology.

Age-dependent Role of Microvascular Endothelial and Polymorphonuclear Cells in Lipopolysaccharide-induced Acute Kidney Injury

M. van Meurs, M. Struys, G. Molema, 2012, Anesthesiology.

Effects of p38 mitogen-activated protein kinase inhibition on anti-neutrophil cytoplasmic autoantibody pathogenicity in vitro and in vivo

G. Molema, P. Heeringa, J. Zwerina, 2010, Annals of the rheumatic diseases.

Effects of p 38 mitogen-activated protein kinase inhibition on anti-neutrophil cytoplasmic autoantibody pathogenicity in vitro and in vivo

G. Molema, P. Heeringa, J. Zwerina, 2022 .

In vitro up-regulation of E-selectin and induction of interleukin-6 in endothelial cells by autoantibodies in Wegener's granulomatosis and microscopic polyangiitis.

R. van Wijk, J. Willem, G. Molema, 1999, Clinical and experimental rheumatology.

A possible role for spontaneous interleukin-8 production by acute myeloid leukemic cells in angiogenesis related processes: work in progress.

W. Kamps, E. Vellenga, G. Molema, 2001, Medical and pediatric oncology.

Anti-VCAM-1 SAINT-O-Somes enable endothelial-specific delivery of siRNA and downregulation of inflammatory genes in activated endothelium in vivo.

J. Kamps, G. Molema, P. Zwiers, 2014, Journal of controlled release : official journal of the Controlled Release Society.

Perioperative Conditions Affect Long-term Hypertrophic Scar Formation

G. Molema, W. M. van der Veer, F. Niessen, 2010, Annals of plastic surgery.

Relationship between duration of brain death and hemodynamic (in)stability on progressive dysfunction and increased immunologic activation of donor kidneys.

G. Molema, R. Ploeg, R. van Schilfgaarde, 2003, Kidney international.

Platelet Endothelial Cell Adhesion Molecule-1, a Putative Receptor for the Adhesion of Streptococcus pneumoniae to the Vascular Endothelium of the Blood-Brain Barrier

G. Molema, J. Bijlsma, F. Iovino, 2014, Infection and Immunity.

University of Groningen Platelet Endothelial Cell Adhesion Molecule-1, a Putative Receptor for the Adhesion of Streptococcus pneumoniae to the Vascular Endothelium of the Blood-Brain Barrier Iovino,

G. Molema, J. Bijlsma, F. Iovino, 2014 .

Endothelial cells internalize and degrade RGD-modified proteins developed for tumor vasculature targeting.

G. Molema, H. Moorlag, R. Kok, 2002, Journal of controlled release : official journal of the Controlled Release Society.

Inhibition of cytomegalovirus infection by lactoferrin in vitro and in vivo.

M. Harmsen, G. Molema, D. Meijer, 2004, Antiviral research.

(Glyco)-protein drug carriers with an intrinsic therapeutic activity : The concept of dual targeting

D. Zeeuw, G. Molema, D. Meijer, 1996 .

Neoglycoproteins as carriers for antiviral drugs: synthesis and analysis of protein-drug conjugates.

P. Herdewijn, G. Molema, D. Meijer, 1991, Journal of medicinal chemistry.

MACROPHAGE INFLUX AND PHENOTYPE DURING NORMOTROPHIC AND HYPERTROPHIC SCAR FORMATION IN HUMANS

E. Middelkoop, G. Molema, R. Beelen, 2011 .

Kidney histopathology in lethal human sepsis

M. van Meurs, G. Molema, J. Moser, 2018, Critical Care.

The renal angiopoietin/Tie2 system in lethal human sepsis

M. van Meurs, A. Diepstra, G. Molema, 2014, Critical Care.

Preparation and Functional Evaluation of RGD-Modified Proteins as r v â 3 Integrin Directed Therapeutics

G. Molema, H. Moorlag, M. Everts, 2022 .

Selective targeting of pentoxifylline to hepatic stellate cells using a novel platinum-based linker technology.

G. Molema, R. Kok, D. Meijer, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Spatiotemporal expression of chemokines and chemokine receptors in experimental anti‐myeloperoxidase antibody‐mediated glomerulonephritis

G. Molema, P. Heeringa, S. Satchell, 2009, Clinical and experimental immunology.

Effect of repetitive impacts on subcutaneous tissue discolouration in potato tubers

G. Molema, J. V. V. D. Berg, H. Breteler, 1997 .

RGD‐modified anti‐CD3 antibodies redirect cytolytic capacity of cytotoxic T lymphocytes toward αvβ3‐expressing endothelial cells

S. Withoff, G. Molema, R. Kok, 2004 .

Rocking the foundations of solid tumor growth by attacking the tumor's blood supply.

A. Griffioen, G. Molema, Grietje Molema, 1998, Immunology today.

Microreview Signalling or binding: the role of the platelet-activating factor receptor in invasive pneumococcal disease

G. Molema, J. Bijlsma, M. Brouwer, 2013 .

Off-Pump CABG Surgery Reduces Systemic Inflammation Compared With On-Pump Surgery but Does Not Change Systemic Endothelial Responses: A Prospective Randomized Study

M. van Meurs, M. Struys, A. Absalom, 2014, Shock.

Construction and characterization of a bispecific diabody for retargeting T cells to human carcinomas

B. Kroesen, G. Molema, R. Roovers, 1998, International journal of cancer.

Streptococcus pneumoniae Interacts with pIgR Expressed by the Brain Microvascular Endothelium but Does Not Co-Localize with PAF Receptor

G. Molema, J. Bijlsma, F. Iovino, 2014, PloS one.

University of Groningen Streptococcus pneumoniae Interacts with pIgR Expressed by the Brain Microvascular Endothelium but Does Not Co-Localize with PAF Receptor Iovino,

G. Molema, J. Bijlsma, F. Iovino, 2014 .

Development of a Combined Lipid-Based Nanoparticle Formulation for Enhanced siRNA Delivery to Vascular Endothelial Cells

J. Kamps, G. Molema, J. Plantinga, 2022, Pharmaceutics.

Liposome‐encapsulated dexamethasone attenuates ventilator‐induced lung inflammation

G. Molema, M. Schultz, J. Kamps, 2011, British journal of pharmacology.

Interaction of targeted liposomes with primary cultured hepatic stellate cells: Involvement of multiple receptor systems.

J. Kamps, G. Molema, D. Meijer, 2006, Journal of hepatology.

Serum concentrations of endothelial cell adhesion molecules and their shedding enzymes and early onset sepsis in newborns in Suriname

M. van Meurs, G. Molema, R. Jongman, 2018, BMJ Paediatrics Open.

Plasma Factors in Severe Early-Onset Preeclampsia Do Not Substantially Alter Endothelial Gene Expression In Vitro

C. Kallenberg, F. Gerbens, J. Aarnoudse, 2005, The Journal of the Society for Gynecologic Investigation: JSGI.

Renal heparan sulfate proteoglycans modulate fibroblast growth factor 2 signaling in experimental chronic transplant dysfunction.

Kiran K. Katta, G. Navis, G. Molema, 2013, The American journal of pathology.

Differential effects of NF-κB and p38 MAPK inhibitors and combinations thereof on TNF-α- and IL-1β-induced proinflammatory status of endothelial cells in vitro

M. Rots, J. Schouten, P. Limburg, 2005 .

Preparation and functional evaluation of RGD-modified proteins as alpha(v)beta(3) integrin directed therapeutics.

Grietje Molema, G. Molema, H. Moorlag, 2002, Bioconjugate chemistry.

RGD-avidin–biotin pretargeting to αvβ3 integrin enhances the proapoptotic activity of TNFα related apoptosis inducing ligand (TRAIL)

W. Quax, G. Molema, R. Kok, 2007, Apoptosis.

Analysis of in Vivo Endothelial Cell Activation Applying RT‐PCR following Endothelial Cell Isolation by Laser Dissection Microscopy

G. Molema, S. Ásgeirsdóttir, N. Werner, 2002, Annals of the New York Academy of Sciences.

Improved efficacy of alphavbeta3-targeted albumin conjugates by conjugation of a novel auristatin derivative.

G. Molema, R. Kok, P. Senter, 2007, Molecular pharmaceutics.

Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation.

A. Griffioen, G. Molema, Grietje Molema, 2000, Pharmacological reviews.

Targeting of Drugs to the Liver

G. Molema, D. Meijer, 1995, Seminars in liver disease.

Absence of In Vivo Generalized Pro-Inflammatory Endothelial Activation in Severe, Early-Onset Preeclampsia

C. Kallenberg, J. Aarnoudse, G. Molema, 2005, Journal of the Society for Gynecologic Investigation.

Angiopoietin-1 Treatment Reduces Inflammation but Does Not Prevent Ventilator-Induced Lung Injury

M. van Meurs, G. Molema, N. Jansen, 2010, PloS one.

Albumin modified with mannose 6‐phosphate: A potential carrier for selective delivery of antifibrotic drugs to rat and human hepatic stellate cells

P. Olinga, G. Groothuis, G. Molema, 1999, Hepatology.

Targeting of sugar- and charge-modified albumins to fibrotic rat livers: the accessibility of hepatic cells after chronic bile duct ligation.

G. Molema, D. Meijer, L. Beljaars, 1998, Journal of hepatology.

Innovations in studying in vivo cell behavior and pharmacology in complex tissues – microvascular endothelial cells in the spotlight

H. Struijker‐Boudier, E. Verpoorte, R. Bischoff, 2013, Cell and Tissue Research.

Oral Carnosine Supplementation Prevents Vascular Damage in Experimental Diabetic Retinopathy

H. Hammes, M. Harmsen, G. Molema, 2011, Cellular Physiology and Biochemistry.

Approaches to lung cancer treatment using the CD3E×GP-2-directed Bispecific Monoclonal Antibody BIS-1

H. Groen, L. de Leij, E. de Vries, 1997, Cancer Immunology, Immunotherapy.

The influence of charge clustering on the anti-HIV-1 activity and in vivo distribution of negatively charged albumins.

B. Berkhout, G. Molema, D. Meijer, 2002, Biochemical pharmacology.

Targeting Rapamycin to Podocytes Using a Vascular Cell Adhesion Molecule-1 (VCAM-1)-Harnessed SAINT-Based Lipid Carrier System

Shima Gholizadeh, J. Kamps, G. Molema, 2015, PloS one.

Dissemination of Rat Cytomegalovirus through Infected Granulocytes and Monocytes In Vitro and In Vivo

M. Harmsen, G. Molema, D. Meijer, 2003, Journal of Virology.

CYTOMEGALOVIRUS (CMV)-SPECIFIC ANTIBODIES INHIBIT THE IN VITRO GENERATION OF CMV PP65 ANTIGENEMIA IN POLYMORPHONUCLEAR CELLS

M. Harmsen, G. Molema, T. The, 2000 .

Effects of Brain Death and Hemodynamic Status on Function and Immunologic Activation of the Potential Donor Liver in the Rat

P. de Vos, A. Girbes, G. Molema, 2000, Annals of surgery.

Oral Presentations—Abstracts

A. Eggermont, K. Edwards, A. Chanan-Khan, 2003, Turkish Journal of Biochemistry.

Dexamethasone coupled to albumin is selectively taken up by rat nonparenchymal liver cells and attenuates LPS-induced activation of hepatic cells.

P. Olinga, G. Molema, D. Meijer, 2000, Journal of hepatology.

Molecular pathways of endothelial cell activation for (targeted) pharmacological intervention of chronic inflammatory diseases.

J. Kamps, G. Molema, R. Kok, 2005, Current vascular pharmacology.

Drug Targeting: Organ-Specific Strategies

Grietje Molema, G. Molema, D. Meijer, 2001 .

Potential cellular and molecular causes of hypertrophic scar formation.

P. V. van Zuijlen, E. Middelkoop, M. Bloemen, 2009, Burns : journal of the International Society for Burn Injuries.

Formaldehyde treated albumin contains monomeric and polymeric forms that are differently cleared by endothelial and Kupffer cells of the liver: evidence for scavenger receptor heterogeneity.

G. Molema, D. Meijer, T. V. van Berkel, 1991, Biochemical and biophysical research communications.

Angiogenesis in Synchronous and Metachronous Colorectal Liver Metastases: The Liver as a Permissive Soil

J. Kamps, G. Molema, H. Moorlag, 2012, Annals of surgery.

TARGETING OF DRUGS TO VARIOUS BLOOD-CELL TYPES USING (NEO-)GLYCOPROTEINS, ANTIBODIES AND OTHER PROTEIN CARRIERS

G. Molema, D. Meijer, 1994 .

Targeting of antiviral drugs to T4-lymphocytes. Anti-HIV activity of neoglycoprotein-AZTMP conjugates in vitro.

E. De Clercq, R. Pauwels, G. Molema, 1990, Biochemical pharmacology.

Case Report: Generating Hypotheses by Discovering Implicit Associations in the Literature: A Case Report of a Search for New Potential Therapeutic Uses for Thalidomide

Marc Weeber, Alan R. Aronson, Henny Klein, 2003, J. Am. Medical Informatics Assoc..

Design, synthesis, and biological evaluation of a dual tumor-specific motive containing integrin-targeted plasmin-cleavable doxorubicin prodrug.

H. W. Scheeren, G. Molema, H. Pinedo, 2002, Molecular cancer therapeutics.

Delivery of the anti-HIV drug azidothymidine (AZT) to T-lymphocytes with neoglycoprotein carriers

G. Molema, 1992 .

Characteristics of the hepatic stellate cell-selective carrier mannose 6-phosphate modified albumin (M6P(28)-HSA).

P. Olinga, G. Groothuis, P. de Bleser, 2001, Liver.

Simultaneous analysis of azidothymidine and its mono-, di- and triphosphate derivatives in biological fluids, tissue and cultured cells by a rapid high-performance liquid chromatographic method.

G. Molema, D. Meijer, R. Jansen, 1992, Journal of chromatography.

Syntheses and structure-activity relationships for some triazolyl p38α MAPK inhibitors.

J. Seerden, J. Kamps, G. Molema, 2014, Bioorganic & medicinal chemistry letters.

Targeted Drug Delivery to the Tumor Neovasculature

G. Molema, 2008 .

Potent in vitro anti-human immunodeficiency virus-1 activity of modified human serum albumins.

E. De Clercq, R. Pauwels, G. Molema, 1991, Molecular pharmacology.

Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF‐A and TGFβ2 in vascular abnormalization

H. Augustin, F. Pontén, P. Georgii‐Hemming, 2012, The Journal of pathology.

Identification of epigenetically silenced genes in tumor endothelial cells.

J. Herman, M. van Engeland, A. Griffioen, 2007, Cancer research.

Tumor Infarction in Mice by Antibody-Directed Targeting of Tissue Factor to Tumor Vasculature

Grietje Molema, Philip E. Thorpe, Xianming Huang, 1997, Science.

Bench-to-bedside review: Angiopoietin signalling in critical illness – a future target?

M. van Meurs, J. Ligtenberg, G. Molema, 2009, Critical care.

Angiogenesis treatment, new concepts on the horizon

G. Molema, R. Griffin, R. Dings, 2006, Angiogenesis.

University of Groningen Interactions between Blood-Borne Streptococcus pneumoniae and the Blood-Brain Barrier Preceding Meningitis

G. Molema, H. Moorlag, C. Orihuela, 2018 .

MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation.

M. van Meurs, T. Rabelink, B. Banas, 2012, American journal of physiology. Renal physiology.

Hypoxia-inducible factor-1 as regulator of angiogenesis in rheumatoid arthritis - therapeutic implications.

C. Kallenberg, G. Molema, J. Westra, 2010, Current medicinal chemistry.

Recent Developments in the Construction of Bispecific Antibodies

B. Kroesen, G. Molema, W. Helfrich, 1998 .

Evaluation of RGD-targeted albumin carriers for specific delivery of auristatin E to tumor blood vessels.

G. Molema, R. Kok, R. Zabinski, 2006, Bioconjugate chemistry.

An SV40 large T-antigen immortalized human umbilical vein endothelial cell line for anti-endothelial cell antibody detection.

R. van Wijk, A. V. D. Van Der Zee, G. Molema, 2001, Clinical and experimental rheumatology.

Heterogeneity in endothelial responsiveness to cytokines, molecular causes, and pharmacological consequences.

G. Molema, 2010, Seminars in thrombosis and hemostasis.

Development of vasculature targeting strategies for the treatment of cancer and chronic inflammatory diseases.

G. Molema, M. Everts, R. Kok, 2002, Biotechnology annual review.

One-Step Method for Endothelial Cell Isolation from Large Human Blood Vessels Using Fibrin Glue

G. Molema, K. Jong, M. Ruiters, 2000, Laboratory Investigation.

Characterization of immortalized human umbilical and iliac vein endothelial cell lines after transfection with SV40 large T‐antigen

R. van Wijk, G. Molema, R. Veenstra, 2000, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Epigenetic regulation of tumor endothelial cell anergy: silencing of intercellular adhesion molecule-1 by histone modifications.

M. O. oude Egbrink, M. van Engeland, A. Griffioen, 2006, Cancer research.

Hepatocellular Carcinomas in Cirrhotic and Noncirrhotic Human Livers Share Angiogenic Characteristics

E. J. van der Jagt, S. Poppema, G. Molema, 2010, Annals of Surgical Oncology.

The angiopoietin 1/angiopoietin 2 balance as a prognostic marker in primary glioblastoma multiforme.

W. D. den Dunnen, G. Molema, M. Wagemakers, 2009, Journal of neurosurgery.

CD3 directed bispecific antibodies induce increased lymphocyte–endothelial cell interactions in vitro

B. Kroesen, G. Molema, D. Meijer, 2000, British Journal of Cancer.

Markers of endothelial cell activation in suspected late onset neonatal sepsis in Surinamese newborns: a pilot study.

M. van Meurs, G. Molema, R. Jongman, 2019, Translational pediatrics.

Endothelial IRF-1 regulates LPS-induced VCAM-1 expression independent of NF-κB

J. Kamps, G. Molema, P. Zwiers, 2019 .

Endothelium-targeted delivery of dexamethasone by anti-VCAM-1 SAINT-O-Somes in mouse endotoxemia

M. van Meurs, J. Kamps, G. Molema, 2018, PloS one.

Low Serum Angiopoietin-1, High Serum Angiopoietin-2, and High Ang-2/Ang-1 Protein Ratio are Associated with Early Onset Sepsis in Surinamese Newborns

M. van Meurs, G. Molema, R. Jongman, 2017, Shock.

Endothelial Interferon Regulatory Factor 1 Regulates Lipopolysaccharide-Induced VCAM-1 Expression Independent of NFκB

M. van Meurs, J. Kamps, G. Molema, 2017, Journal of Innate Immunity.

Endothelium-targeted delivery of dexamethasone by anti-VCAM-1 SAINT-O- Somes in lipopolysaccharide “double hit” induced endotoxemia

J. Kamps, G. Molema, M. Meurs, 2015 .

University of Groningen Angiopoietin / Tie 2 Dysbalance Is Associated with Acute Kidney Injury after Cardiac Surgery Assisted by Cardiopulmonary Bypass

G. Molema, J. Zijlstra, M. Meurs, 2017 .

Angiopoietin/Tie2 Dysbalance Is Associated with Acute Kidney Injury after Cardiac Surgery Assisted by Cardiopulmonary Bypass

M. van Meurs, G. Molema, J. Zijlstra, 2015, PloS one.

Delivery of pharmacologically active dexamethasone into activated endothelial cells by dexamethasone-anti-E-selectin immunoconjugate.

Grietje Molema, G. Molema, M. Everts, 2003, Biochemical pharmacology.

Successful Targeting to Rat Hepatic Stellate Cells Using Albumin Modified with Cyclic Peptides That Recognize the Collagen Type VI Receptor*

D. Schuppan, P. de Bleser, G. Molema, 2000, The Journal of Biological Chemistry.

Targeted SAINT-O-Somes for improved intracellular delivery of siRNA and cytotoxic drugs into endothelial cells.

J. Kamps, G. Molema, S. Ásgeirsdóttir, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Heterogeneity in responses of microvascular endothelial cells during inflammation

G. Molema, 2010 .

Bi-specific antibody therapy for the treatment of cancer.

S. Withoff, G. Molema, W. Helfrich, 2001, Current opinion in molecular therapeutics.

Pharmacological inhibition of focal adhesion kinase 1 (FAK1) and anaplastic lymphoma kinase (ALK) identified via kinome profile analysis attenuates lipopolysaccharide-induced endothelial inflammatory activation.

M. van Meurs, G. Molema, J. Moser, 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Targeting of RGD‐modified proteins to tumor vasculature: A pharmacokinetic and cellular distribution study

J. Proost, G. Molema, H. Moorlag, 2002, International journal of cancer.

Tumor‐targeted immune complex formation: Effects on myeloid cell activation and tumor‐directed immune cell migration

B. Kroesen, S. Jacobs, G. Molema, 2002, International journal of cancer.

Induction of organ dysfunction and activation of inflammatory markers in donor liver and kidney during hypotensive brain death.

P. de Vos, A. Girbes, G. Molema, 1999, Transplantation Proceedings.

Targeted siRNA delivery to diseased microvascular endothelial cells—Cellular and molecular concepts

J. Kamps, G. Molema, Piotr S. Kowalski, 2011, IUBMB life.

Scanning electron microscopic analysis of endothelial cell coverage and quality in large vessels from multi‐organ donors: effects of preservation on endothelial cell integrity

G. Molema, F. Dijk, M. Ruiters, 1999, Clinical Transplantation.

A novel strategy to modify adenovirus tropism and enhance transgene delivery to activated vascular endothelial cells in vitro and in vivo.

M. Rots, G. Molema, H. Moorlag, 2004, Human gene therapy.

Deeper penetration into tumor tissues and enhanced in vivo antitumor activity of liposomal paclitaxel by pretreatment with angiogenesis inhibitor SU5416.

G. Molema, K. Higaki, Toshikiro Kimura, 2012, Molecular pharmaceutics.

Analyzing Neutrophil Morphology, Mechanics, and Motility in Sepsis: Options and Challenges for Novel Bedside Technologies

G. Molema, F. Plötz, R. Zonneveld, 2016, Critical care medicine.

The foreign body reaction to a biodegradable biomaterial differs between rats and mice.

G. Molema, P. V. van Wachem, M. V. van Luyn, 2000, Journal of biomedical materials research.

LIGAND-TARGETED LIPOSOMES DIRECTED AGAINST PATHOLOGICAL VASCULATURE

R. Schiffelers, G. Molema, G. Koning, 2002, Journal of liposome research.

Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin.

R. Schiffelers, G. Molema, G. Koning, 2003, Journal of controlled release : official journal of the Controlled Release Society.

Vascular Endothelium in Inflamed Tissue as a Target for Site Selective Delivery of Drugs

G. Molema, M. Everts, D. Meijer, 2001 .

A rapid and versatile method for harnessing scFv antibody fragments with various biological effector functions.

B. Kroesen, T. Luther, V. Magdolen, 2000, Journal of immunological methods.

Renal Klotho is Reduced in Septic Patients and Pretreatment With Recombinant Klotho Attenuates Organ Injury in Lipopolysaccharide-Challenged Mice

M. van Meurs, G. Molema, J. Moser, 2018, Critical care medicine.

University of Groningen Renal Klotho is Reduced in Septic Patients and Pretreatment With Recombinant Klotho Attenuates Organ Injury in Lipopolysaccharide-Challenged Mice Jou-Valencia,

G. Molema, J. Moser, J. Zijlstra, 2018 .

Renal Klotho is Reduced

G. Molema, J. Moser, J. Zijlstra, 2018 .

Synthesis and structure-activity relationships of 4-fluorophenyl-imidazole p38α MAPK, CK1δ and JAK2 kinase inhibitors.

J. Seerden, J. Kamps, G. Molema, 2014, Bioorganic & medicinal chemistry letters.

Renal microvascular endothelial cell responses in sepsis-induced acute kidney injury

M. van Meurs, J. Kamps, G. Molema, 2021, Nature Reviews Nephrology.

Microvascular endothelial cell heterogeneity: general concepts and pharmacological consequences for anti-angiogenic therapy of cancer

Elise Langenkamp, G. Molema, 2008, Cell and Tissue Research.

Analysis of in vitro lymphocyte adhesion and transendothelial migration by fluorescent-beads-based flow cytometric cell counting.

B. Kroesen, G. Molema, D. Meijer, 1998, Cytometry.

Transporting silence: design of carriers for siRNA to angiogenic endothelium.

R. Schiffelers, G. Molema, G. Storm, 2005, Journal of controlled release : official journal of the Controlled Release Society.

Comparison of E-selectin expression at mRNA and protein levels in murine models of inflammation

J. Twisk, G. Molema, M. Everts, 2003, Inflammation Research.

Targeted transfection increases siRNA uptake and gene silencing of primary endothelial cells in vitro--a quantitative study.

I. A. D. de Graaf, J. Kamps, G. Molema, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Vascular endothelial growth factor receptor 2 (VEGFR‐2) signalling activity in paediatric pilocytic astrocytoma is restricted to tumour endothelial cells

W. Kamps, W. D. den Dunnen, G. Molema, 2011, Neuropathology and applied neurobiology.

A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets.

K. Nicolay, A. Griffioen, G. Molema, 2004, Bioconjugate chemistry.

Tumor Vascular Endothelium: Barrier or Target in Tumor Directed Drug Delivery and Immunotherapy

Grietje Molema, G. Molema, D. Meijer, 2004, Pharmaceutical Research.

In Vivo Characteristics of Cationic Liposomes as Delivery Vectors for Gene Therapy

G. Molema, D. Hoekstra, S. Audouy, 2002, Pharmaceutical Research.

Pericyte Migration

H. Hammes, G. Molema, F. vom Hagen, 2008, Diabetes.

Identification of LPS-Activated Endothelial Subpopulations With Distinct Inflammatory Phenotypes and Regulatory Signaling Mechanisms

M. van Meurs, G. Molema, J. Moser, 2019, Front. Immunol..

Shock-induced stress induces loss of microvascular endothelial Tie2 in the kidney which is not associated with reduced glomerular barrier function.

M. van Meurs, I. A. D. de Graaf, G. Molema, 2009, American journal of physiology. Renal physiology.

The angiogenic makeup of human hepatocellular carcinoma does not favor vascular endothelial growth factor/angiopoietin‐driven sprouting neovascularization

S. Poppema, G. Molema, P. Zwiers, 2008, Hepatology.

Vascular endothelial growth factor receptor 2 inhibition in-vivo affects tumor vasculature in a tumor type-dependent way and downregulates vascular endothelial growth factor receptor 2 protein without a prominent role for miR-296

Elise Langenkamp, G. Molema, P. Zwiers, 2012, Anti-cancer drugs.

The flow dependency of Tie2 expression in endotoxemia

H. Hammes, W. Aird, M. Struys, 2013, Intensive Care Medicine.

Mechanical force and subcutaneous tissue discolouration in potato

G. J. Molema, G. Molema, 1999 .

Serum as a modulator of lipoplex‐mediated gene transfection: dependence of amphiphile, cell type and complex stability

G. Molema, D. Hoekstra, S. Audouy, 2000, The journal of gene medicine.

Volume estimation of potatoes partly covered with dirt tare

J. W. Hofstee, G. J. Molema, G. Molema, 2003 .

Correlation of MicroRNA-16, MicroRNA-21 and MicroRNA-101 Expression with Cyclooxygenase-2 Expression and Angiogenic Factors in Cirrhotic and Noncirrhotic Human Hepatocellular Carcinoma

A. van den Berg, G. Molema, Wenjiao Zeng, 2014, PloS one.

Site-Specific Inhibition of Glomerulonephritis Progression by Targeted Delivery of Dexamethasone to Glomerular Endothelium

C. Kallenberg, J. Kamps, G. Molema, 2007, Molecular Pharmacology.

Organ Perfusion During Cardiopulmonary Bypass: Blood Rheology and Endothelial (Dys)function. Acute Isovolemic Hemodilution Triggers Pro–Inflammatory and Pro–Coagulatory Endothelial Activation in Vital Organs: Role of Erythrocytes Aggregation

G. Rakhorst, G. Molema, R. Ploeg, 2005 .

Combining laser microdissection and microRNA expression profiling to unmask microRNA signatures in complex tissues.

G. Molema, P. Zwiers, M. Hackl, 2019, BioTechniques.

Embracing Diversity, Equity, and Inclusion in the Scientific Community—Viewpoints of the Diversity, Equity, and Inclusion Committee of the North American Vascular Biology Organization

E. Aikawa, M. Ushio-Fukai, G. Molema, 2022, Frontiers in Cardiovascular Medicine.

Complex effect of atorvastatin on angiogenic gene expression in normoxic and hypoxic microvascular endothelial cells

G. Molema, A. Józkowicz, J. Dulak, 2005 .

Liposomal targeting of angiogenic vasculature.

R. Schiffelers, G. Molema, G. Storm, 2005, Current drug delivery.

Rational Design of RGD–Albumin Conjugates for Targeted Delivery of the VEGF‐R Kinase Inhibitor PTK787 to Angiogenic Endothelium

G. Kéri, G. Molema, R. Kok, 2006, ChemMedChem.

RGD-modified anti-CD3 antibodies redirect cytolytic capacity of cytotoxic T lymphocytes toward alphavbeta3-expressing endothelial cells.

S. Withoff, G. Molema, R. Kok, 2004, International journal of cancer.

Drug Targeting: Basic Concepts and Novel Advances

G. Molema, 2001 .

Design of vascular endothelium-specific drug-targeting strategies for the treatment of cancer.

G. Molema, 2005, Acta biochimica Polonica.

Effective siRNA delivery to inflamed primary vascular endothelial cells by anti-E-selectin and anti-VCAM-1 PEGylated SAINT-based lipoplexes.

J. Kamps, G. Molema, Piotr S. Kowalski, 2014, International journal of pharmaceutics.

Delivery of the p38 MAPkinase inhibitor SB202190 to angiogenic endothelial cells: development of novel RGD-equipped and PEGylated drug-albumin conjugates using platinum(II)-based drug linker technology.

G. Kéri, G. Molema, R. Kok, 2006, Bioconjugate chemistry.

Corrigendum: Shock-induced stress induces loss of microvascular endothelial Tie2 in the kidney which is not associated with reduced glomerular barrier function (vol 297, pg F272, 2009)

G. Molema, J. Zijlstra, M. Meurs, 2017 .

Behaviour of Human Umbilical Vein Endothelial Cells (HUVEC) Cultivated in Microfluidic channels

E. Verpoorte, G. Molema, P. Mulder, 2006, 2006 International Conference on Microtechnologies in Medicine and Biology.

Systemic administration of E-selectin-directed dexamethasone liposomes attenuates pulmonary inflammation in a mouse model of ventilator-induced lung injury

G. Molema, M. Schultz, J. Kamps, 2009, Critical Care.

Reduced Tie2 in Microvascular Endothelial Cells Is Associated with Organ-Specific Adhesion Molecule Expression in Murine Health and Endotoxemia

M. van Meurs, G. Molema, P. Zwiers, 2023, Cells.

Machine perfused donor kidneys as a source of human renal endothelial cells.

M. Daha, G. Molema, J. van den Born, 2021, American journal of physiology. Renal physiology.

SAINT-liposome-polycation particles, a new carrier for improved delivery of siRNAs to inflamed endothelial cells.

J. Kamps, G. Molema, Piotr S. Kowalski, 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Disease-induced drug targeting using novel peptide-ligand albumins.

G. Molema, D. Meijer, L. Beljaars, 2001, Journal of controlled release : official journal of the Controlled Release Society.

Measurement of functional and morphodynamic neutrophil phenotypes in systemic inflammation and sepsis

G. Molema, F. Plötz, R. Zonneveld, 2016, Critical Care.

Heterogenous Renal Injury Biomarker Production Reveals Human Sepsis-Associated Acute Kidney Injury Subtypes

M. van Meurs, G. Molema, P. Zwiers, 2019, Critical care explorations.

Localized optical monitoring of cytoskeletal changes in confluent endothelial cell layers upon exposure to xenobiotics

E. Verpoorte, G. Molema, M. Grajewski, 2018 .

New ways in RGD-peptide mediated drug targeting to angiogenic endothelium : On the nature of drugs, linkers, and carriers.

R. Schiffelers, G. Molema, R. Kok, 2007 .

EARLY ORGAN-SPECIFIC ENDOTHELIAL ACTIVATION DURING HEMORRHAGIC SHOCK AND RESUSCITATION

M. van Meurs, G. Molema, Francis M. Wulfert, 2007, Shock.