J. Luyendyk

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COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARδ activation

Nigel Mackman, Sudhansu K. Dey, S. Dey, 2007, The Journal of experimental medicine.

Monocyte chemoattractant protein-1-deficiency does not affect steatosis or inflammation in livers of mice fed a methionine-choline-deficient diet

O. Tawfik, J. Luyendyk, Karen M. Kassel, 2010, Laboratory Investigation.

Gastrointestinal , Hepatobiliary and Pancreatic Pathology Tissue Factor-Deficiency and Protease Activated Receptor-1-Deficiency Reduce Inflammation Elicited by Diet-Induced Steatohepatitis in Mice

J. Luyendyk, G. Guo, B. Sullivan, 2010 .

RNA Sequencing Identifies Novel Translational Biomarkers of Kidney Fibrosis.

John N. Hutchinson, U. Kusebauch, Christopher L Moss, 2016, Journal of the American Society of Nephrology : JASN.

Genetic Analysis of the Role of the PI3K-Akt Pathway in Lipopolysaccharide-Induced Cytokine and Tissue Factor Gene Expression in Monocytes/Macrophages1

J. Luyendyk, N. Mackman, G. Schabbauer, 2008, The Journal of Immunology.

Inflammatory Stress and Idiosyncratic Hepatotoxicity: Hints from Animal Models

J. Luyendyk, P. Ganey, R. Roth, 2009, Pharmacological Reviews.

Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding.

Masayuki Yamamoto, J. Luyendyk, A. Slitt, 2013, Free radical biology & medicine.

Keap 1 knockdown increases markers of metabolic syndrome after long-term fat diet feeding

Masayuki Yamamoto, J. Luyendyk, A. Slitt, 2013 .

Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice.

Mitchell R. McGill, H. Jaeschke, J. Luyendyk, 2015, Blood.

Metabonomic evaluation of idiosyncrasy-like liver injury in rats cotreated with ranitidine and lipopolysaccharide.

Royston Goodacre, George G Harrigan, R. Goodacre, 2006, Toxicology and applied pharmacology.

Lipopolysaccharide enhances transforming growth factor β1‐induced platelet‐derived growth factor‐B expression in bile duct epithelial cells

J. Luyendyk, Karen M. Kassel, B. Sullivan, 2012, Journal of gastroenterology and hepatology.

Inflammation and Hepatotoxicity

J. Luyendyk, P. Ganey, R. Roth, 2010 .

Monocytes / Macrophages Cytokine and Tissue Factor Gene Expression Pathway in Lipopolysaccharide-Induced Genetic Analysis of the Role of the PI 3 K-Akt

J. Luyendyk, N. Mackman, G. Schabbauer, 2008 .

A Novel Class of Antioxidants Inhibit LPS Induction of Tissue Factor by Selective Inhibition of the Activation of ASK1 and MAP Kinases

W. Min, Rong Zhang, J. Luyendyk, 2007, Arteriosclerosis, thrombosis, and vascular biology.

Genetic susceptibility to thrombosis

J. Luyendyk, N. Mackman, R. Tilley, 2006, Current atherosclerosis reports.

Targeting Phospholipase D4 Attenuates Kidney Fibrosis.

Sarah A. Boswell, Zachary T Herbert, S. Boswell, 2017, Journal of the American Society of Nephrology : JASN.

H1-antihistamines exacerbate high-fat diet-induced hepatic steatosis in wild-type but not in apolipoprotein E knockout mice.

J. Luyendyk, C. Klaassen, G. Reed, 2014, American journal of physiology. Gastrointestinal and liver physiology.

Hemostasis and Liver Regeneration

J. Luyendyk, P. Starlinger, D. Groeneveld, 2020, Seminars in Thrombosis and Hemostasis.

Interleukin-6 Drives Key Pathologic Outcomes in Experimental Acetaminophen-induced Liver Failure

A. Dorrance, B. Bhushan, U. Apte, 2021, bioRxiv.

Dichotomous Role of Plasmin in Regulation of Macrophage Function after Acetaminophen Overdose.

T. Billiar, B. Copple, J. Luyendyk, 2019, The American journal of pathology.

Coagulation-Mediated Hypoxia and Neutrophil-Dependent Hepatic Injury in Rats Given Lipopolysaccharide and Ranitidine

J. Luyendyk, P. Ganey, R. Roth, 2005, Journal of Pharmacology and Experimental Therapeutics.

Hepatocyte tissue factor activates the coagulation cascade in mice.

J. Luyendyk, N. Mackman, S. C. Bishop, 2013, Blood.

Farnesoid X Receptor Deficiency Induces Nonalcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Knockout Mice Fed a High-Fat Diet

O. Tawfik, J. Luyendyk, G. Guo, 2009, Journal of Pharmacology and Experimental Therapeutics.

Fibrin(ogen) drives repair after acetaminophen-induced liver injury via leukocyte αMβ2 integrin-dependent upregulation of Mmp12.

J. Froehlich, J. Luyendyk, A. Kopec, 2017, Journal of hepatology.

Circulating microparticle tissue factor activity Is increased in patients with cirrhosis

J. Luyendyk, N. Mackman, P. Rautou, 2014, Hepatology.

Coagulation parameters following equine herpesvirus type 1 infection in horses

M. Wilson, J. Luyendyk, A. Kopec, 2019, Equine veterinary journal.

Thrombin Inhibition with Dabigatran Protects against High-Fat Diet–Induced Fatty Liver Disease in Mice

J. Luyendyk, A. Kopec, Karen M. Kassel, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Therapeutic administration of the direct thrombin inhibitor argatroban reduces hepatic inflammation in mice with established fatty liver disease.

B. Copple, J. Luyendyk, Karen M. Kassel, 2012, The American journal of pathology.

Steatosis DeLIVERs high-sensitivity C-reactive protein.

J. Luyendyk, G. Guo, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Gastrointestinal , Hepatobiliary , and Pancreatic Pathology Protease-Activated Receptor 1 and Hematopoietic Cell Tissue Factor Are Required for Hepatic Steatosis in Mice Fed a Western Diet

O. Tawfik, J. Luyendyk, N. Mackman, 2011 .

Bile acid-CoA:amino acid N-acyltransferase gene knockout alters early life development, the gut microbiome and reveals unusual bile acid conjugates in mice

J. Luyendyk, R. Quinn, S. O’Reilly, 2022, bioRxiv.

High fat diet delays plasmin generation in a thrombomodulin-dependent manner in mice.

D. Lawrence, J. Luyendyk, A. Kopec, 2020, Blood.

Metformin Prevents Endotoxin-Induced Liver Injury after Partial Hepatectomy

G. Arteel, J. Luyendyk, R. Roth, 2006, Journal of Pharmacology and Experimental Therapeutics.

Thrombin promotes diet-induced obesity through fibrin-driven inflammation

J. Luyendyk, N. Mackman, S. Divanovic, 2017, The Journal of clinical investigation.

Modulating Macrophage Phenotype in Mice Dependent Manner by - a Factor-1of Necrotic Cells in a Hypoxia-Inducible Hepatic Stellate Cells Orchestrate Clearance

Ryan, B. Copple, J. Luyendyk, 2014 .

Hepatic Stellate Cells Orchestrate Clearance of Necrotic Cells in a Hypoxia-Inducible Factor-1α–Dependent Manner by Modulating Macrophage Phenotype in Mice

B. Copple, J. Luyendyk, A. Pace, 2014, The Journal of Immunology.

This information is current as Modulating Macrophage Phenotype in Mice Dependent Manner by − α Factor-1 of Necrotic Cells in a Hypoxia-Inducible Hepatic Stellate Cells Orchestrate Clearance

B. Copple, J. Luyendyk, A. Pace, 2014 .

Role of hepatic fibrin in idiosyncrasy‐like liver injury from lipopolysaccharide‐ranitidine coexposure in rats

J. Luyendyk, P. Ganey, R. Roth, 2004, Hepatology.

Chronic liver injury drives non‐traditional intrahepatic fibrin(ogen) crosslinking via tissue transglutaminase

J. Luyendyk, S. Iismaa, A. Kopec, 2018, Journal of thrombosis and haemostasis : JTH.

Role of the blood coagulation cascade in hepatic fibrosis.

J. Luyendyk, A. Kopec, A. Pant, 2018, American journal of physiology. Gastrointestinal and liver physiology.

Role of the coagulation system in acetaminophen‐induced hepatotoxicity in mice

J. Luyendyk, N. Mackman, P. Ganey, 2007, Hepatology.

Caspase Inhibition Reduces Hepatic Tissue Factor-Driven Coagulation In Vitro and In Vivo

A. Spada, J. Luyendyk, N. Mackman, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Targeting von Willebrand factor in liver diseases: A novel therapeutic strategy?

J. Luyendyk, L. Poole, D. Groeneveld, 2021, Journal of thrombosis and haemostasis : JTH.

Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1.

G. Arteel, J. Luyendyk, R. Roth, 2006, Gastroenterology.

H 1-antihistamines exacerbate high-fat diet-induced hepatic steatosis in wild-type but not in apolipoprotein E knockout mice

J. Luyendyk, C. Klaassen, G. Reed, 2014 .

Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis.

O. Tawfik, J. Luyendyk, G. Guo, 2016, American journal of physiology. Gastrointestinal and liver physiology.

Small heterodimer partner overexpression partially protects against liver tumor development in farnesoid X receptor knockout mice.

O. Tawfik, J. Luyendyk, Karen M. Kassel, 2013, Toxicology and applied pharmacology.

Mechanisms of STAT3 activation in the liver of FXR knockout mice.

O. Tawfik, J. Luyendyk, Karen M. Kassel, 2013, American journal of physiology. Gastrointestinal and liver physiology.

The Role of Hypoxia-Inducible Factor-1 (cid:1) in Acetaminophen Hepatotoxicity

B. Copple, J. Luyendyk, P. Ganey, 2011 .

Fibrin accumulation plays a critical role in the sensitization to lipopolysaccharide‐induced liver injury caused by ethanol in mice

D. Staunton, G. Arteel, J. Luyendyk, 2009, Hepatology.

Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy.

H. Jaeschke, B. Copple, J. Luyendyk, 2014, Journal of hepatology.

Rapamycin enhances LPS induction of tissue factor and tumor necrosis factor-alpha expression in macrophages by reducing IL-10 expression.

J. Luyendyk, N. Mackman, Ruipeng Wang, 2009, Molecular immunology.

IL-17A synergistically enhances bile acid-induced inflammation during obstructive cholestasis.

B. Copple, J. Luyendyk, C. Rockwell, 2013, The American journal of pathology.

The Antifibrinolytic Drug Tranexamic Acid Reduces Liver Injury and Fibrosis in a Mouse Model of Chronic Bile Duct Injury

J. Luyendyk, A. Kopec, N. Joshi, 2014, The Journal of Pharmacology and Experimental Therapeutics.

The multifaceted role of fibrinogen in tissue injury and inflammation.

J. Luyendyk, M. Flick, J. Schoenecker, 2019, Blood.

Role of hemostatic factors in hepatic injury and disease: animal models de‐liver

J. Luyendyk, A. Kopec, N. Joshi, 2016, Journal of thrombosis and haemostasis : JTH.

Insulin Activation of the PI3K/Akt Pathway Reduces LPS-induced Inflammation in Mice

J. Luyendyk, N. Mackman, G. Schabbauer, 2008 .

From the Cover: Coagulation-Driven Hepatic Fibrosis Requires Protease Activated Receptor-1 (PAR-1) in a Mouse Model of TCDD-Elicited Steatohepatitis.

T. Zacharewski, J. Luyendyk, J. Harkema, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Fibrin(ogen)-independent role of plasminogen activators in acetaminophen-induced liver injury.

J. Luyendyk, Karen M. Kassel, B. Sullivan, 2012, The American journal of pathology.

Role of fibrinogen and protease-activated receptors in acute xenobiotic-induced cholestatic liver injury.

J. Luyendyk, N. Mackman, B. Sullivan, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Unique gene expression and hepatocellular injury in the lipopolysaccharide-ranitidine drug idiosyncrasy rat model: comparison with famotidine.

J. Luyendyk, P. Ganey, B. Car, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

GASTROINTESTINAL , HEPATOBILIARY , AND PANCREATIC PATHOLOGY IL-17 A Synergistically Enhances Bile Acid e Induced In fl ammation during Obstructive Cholestasis

Brien, B. Copple, J. Luyendyk, 2013 .

Lymphocytes contribute to biliary injury and fibrosis in experimental xenobiotic-induced cholestasis.

J. Luyendyk, A. Kopec, N. Joshi, 2017, Toxicology.

Evaluation of the chromogenic anti-factor IIa assay to assess dabigatran exposure in geriatric patients with atrial fibrillation in an outpatient setting

J. Luyendyk, B. Buckley, X. Wen, 2016, Thrombosis Journal.

Effect of low-density lipoprotein apheresis on plasma levels of apolipoprotein e4.

J. Luyendyk, C. Gibson, P. Moriarty, 2010, The American journal of cardiology.

Cross‐linking by tissue transglutaminase‐2 alters fibrinogen‐directed macrophage proinflammatory activity

J. Luyendyk, A. Kopec, M. Flick, 2022, Journal of thrombosis and haemostasis : JTH.

Platelets as Modulators of Liver Diseases

J. Luyendyk, T. Lisman, 2017, Seminars in Thrombosis and Hemostasis.

Comparison of DLin-MC3-DMA and ALC-0315 for siRNA Delivery to Hepatocytes and Hepatic Stellate Cells.

J. Luyendyk, C. Kastrup, L. Poole, 2022, Molecular pharmaceutics.

Plasminogen Activator Inhibitor-1 Reduces Tissue-Type Plasminogen Activator-Dependent Fibrinolysis and Intrahepatic Hemorrhage in Experimental Acetaminophen Overdose.

D. Lawrence, J. Luyendyk, A. Kopec, 2018, The American journal of pathology.

Antigen-Presenting Cell Function during Plasmodium yoelii Infection

J. Luyendyk, O. R. Olivas, A. Avery, 2002, Infection and Immunity.

Infection Plasmodium yoelii Antigen-Presenting Cell Function during

J. Luyendyk, O. R. Olivas, A. Avery, 2002 .

Correction to: Direct Amplification of Tissue Factor:Factor VIIa Procoagulant Activity by Bile Acids Drives Intrahepatic Coagulation.

H. Jaeschke, J. Luyendyk, M. Olyaee, 2019, Arteriosclerosis, thrombosis, and vascular biology.

Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice.

B. Copple, D. Kirchhofer, J. Luyendyk, 2009, American journal of physiology. Gastrointestinal and liver physiology.

The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis.

P. Weinreb, S. Violette, J. Luyendyk, 2010, The American journal of pathology.

Gastrointestinal , Hepatobiliary and Pancreatic Pathology The Coagulation System Contributes to V 6 Integrin Expression and Liver Fibrosis Induced by Cholestasis

P. Weinreb, S. Violette, J. Luyendyk, 2010 .

Factor XIII cross-links fibrin(ogen) independent of fibrin polymerization in experimental acute liver injury.

J. Luyendyk, A. Kopec, M. Flick, 2021, Blood.

Endothelial force awakens a mechanism of portal hypertension: It's a neutrophil extracellular trap!

J. Luyendyk, D. Groeneveld, 2019, Journal of thrombosis and haemostasis : JTH.

Fibrin deposition following bile duct injury limits fibrosis through an αMβ2-dependent mechanism.

T. Zacharewski, J. Luyendyk, A. Kopec, 2016, Blood.

Fas-induced apoptosis increases hepatocyte tissue factor procoagulant activity in vitro and in vivo.

J. Luyendyk, N. Mackman, A. Kopec, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Plasmin-mediated Cleavage of High Molecular Weight Kininogen Contributes to Acetaminophen-Induced Acute Liver Failure.

T. Renné, J. Luyendyk, S. Strickland, 2021, Blood.

Elimination of fibrin polymer formation or crosslinking, but not fibrinogen deficiency, is protective against diet‐induced obesity and associated pathologies

J. Luyendyk, C. Kastrup, A. Wolberg, 2022, Journal of thrombosis and haemostasis : JTH.

THROMBOSIS AND HEMOSTASIS Fibrin deposition following bile duct injury limits fi brosis through an a M b 2-dependent mechanism

T. Zacharewski, J. Luyendyk, A. Kopec, 2016 .

Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies.

O. Tawfik, J. Luyendyk, B. Sullivan, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Intrahepatic fibrin(ogen) deposition drives liver regeneration after partial hepatectomy in mice and humans.

J. Luyendyk, A. Kopec, P. Starlinger, 2019, Blood.

Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury.

J. Luyendyk, N. Mackman, R. Pawlinski, 2016, Journal of hepatology.

Ranitidine Treatment during a Modest Inflammatory Response Precipitates Idiosyncrasy-Like Liver Injury in Rats

J. Luyendyk, P. Ganey, R. Roth, 2003, Journal of Pharmacology and Experimental Therapeutics.

THROMBOSIS AND HEMOSTASIS Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice

Mitchell R. McGill, H. Jaeschke, J. Luyendyk, 2015 .

Baat Gene Knockout Alters Post-Natal Development, the Gut Microbiome, and Reveals Unusual Bile Acids in Mice

Anthony L. Schilmiller, J. Luyendyk, A. Schilmiller, 2022, Journal of lipid research.

Role of Fibrin(ogen) in Progression of Liver Disease: Guilt by Association?

J. Luyendyk, A. Kopec, 2016, Seminars in Thrombosis & Hemostasis.

Gastrointestinal , Hepatobiliary , and Pancreatic Pathology Fibrinogen Deficiency Increases Liver Injury and Early Growth Response-1 ( Egr-1 ) Expression in a Model of Chronic Xenobiotic-Induced Cholestasis

B. Copple, J. Luyendyk, Karen M. Kassel, 2011 .

Coagulation in liver toxicity and disease: role of hepatocyte tissue factor.

J. Luyendyk, A. Kopec, 2014, Thrombosis research.

Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor.

J. Luyendyk, P. Ganey, R. Roth, 2004, Chemico-biological interactions.

Bacterial lipopolysaccharide exposure alters aflatoxin B(1) hepatotoxicity: benchmark dose analysis for markers of liver injury.

J. Luyendyk, P. Ganey, R. Roth, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Differential Roles of Unsaturated and Saturated Fatty Acids on Autophagy and Apoptosis in Hepatocytes

B. Copple, J. Luyendyk, W. Ding, 2011, Journal of Pharmacology and Experimental Therapeutics.

Contribution of Host-Derived Tissue Factor to Tumor Neovascularization

J. Rak, J. Luyendyk, N. Mackman, 2008, Arteriosclerosis, thrombosis, and vascular biology.

The role of tumor-and host-related tissue factor pools in oncogene-driven tumor progression.

J. Rak, J. Luyendyk, N. Mackman, 2007, Thrombosis research.

Oncogenes, trousseau syndrome, and cancer-related changes in the coagulome of mice and humans.

J. Rak, J. Luyendyk, N. Mackman, 2006, Cancer research.

Lipopolysaccharide enhances transforming growth factor β 1-induced PDGF-B expression in bile duct epithelial cells

J. Luyendyk, Karen M. Kassel, B. Sullivan, 2012 .

The Role of Hypoxia-Inducible Factor-1α in Acetaminophen Hepatotoxicity

B. Copple, J. Luyendyk, P. Ganey, 2011, Journal of Pharmacology and Experimental Therapeutics.

Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice.

H. Jaeschke, J. Luyendyk, N. Mackman, 2011, Toxicology and applied pharmacology.

Von Willebrand factor delays liver repair after acetaminophen-induced acute liver injury in mice.

J. Luyendyk, R. Roth, K. Williams, 2020, Journal of hepatology.

The role of tumor necrosis factor alpha in lipopolysaccharide/ranitidine-induced inflammatory liver injury.

J. Luyendyk, P. Ganey, R. Roth, 2007, Toxicological sciences : an official journal of the Society of Toxicology.

PAR-1 contributes to the innate immune response during viral infection.

D. Kirchhofer, J. Luyendyk, N. Mackman, 2013, The Journal of clinical investigation.

A balance between TFPI and thrombin-mediated platelet activation is required for murine embryonic development.

J. Luyendyk, H. Weiler, A. Mast, 2015, Blood.

Toxicogenomic analysis reveals profibrogenic effects of trichloroethylene in autoimmune-mediated cholangitis in mice.

J. Luyendyk, A. Kopec, Karen M. Kassel, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Trichloroethylene Exposure Reduces Liver Injury in a Mouse Model of Primary Biliary Cholangitis

J. Luyendyk, M. Gershwin, L. Lash, 2017, Toxicological sciences : an official journal of the Society of Toxicology.

Regulation of Transforming Growth Factor-β1-Dependent Integrin β6 Expression by p38 Mitogen-Activated Protein Kinase in Bile Duct Epithelial Cells

J. Luyendyk, Karen M. Kassel, B. Sullivan, 2011, Journal of Pharmacology and Experimental Therapeutics.

Insulin Activation of the Phosphatidylinositol 3-Kinase/Protein Kinase B (Akt) Pathway Reduces Lipopolysaccharide-Induced Inflammation in Mice

J. Luyendyk, G. Schabbauer, M. Tencati, 2008, Journal of Pharmacology and Experimental Therapeutics.

TLR4/CD14-mediated PI3K activation is an essential component of interferon-dependent VSV resistance in macrophages.

Zhengfan Jiang, J. Luyendyk, N. Mackman, 2008, Molecular immunology.

Modest Inflammation Enhances Diclofenac Hepatotoxicity in Rats: Role of Neutrophils and Bacterial Translocation

Michael J Liguori, Eric A G Blomme, J. Waring, 2006, Journal of Pharmacology and Experimental Therapeutics.

Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin.

D. Johns, D. Kirchhofer, J. Luyendyk, 2012, The Journal of clinical investigation.

Coagulation-Dependent Gene Expression and Liver Injury in Rats Given Lipopolysaccharide with Ranitidine but Not with Famotidine

Lois D Lehman-McKeeman, J. Luyendyk, P. Ganey, 2006, Journal of Pharmacology and Experimental Therapeutics.

Application of high-throughput Fourier-transform infrared spectroscopy in toxicology studies: contribution to a study on the development of an animal model for idiosyncratic toxicity.

Royston Goodacre, George G Harrigan, R. Goodacre, 2004, Toxicology letters.

Plasminogen Activator Inhibitor‐1 Is Critical in Alcohol‐Enhanced Acute Lung Injury in Mice

G. Arteel, J. Luyendyk, J. Roman, 2017, American journal of respiratory cell and molecular biology.

Dose‐dependent effects of alpha‐naphthylisothiocyanate disconnect biliary fibrosis from hepatocellular necrosis

J. Luyendyk, A. Kopec, N. Joshi, 2017, Journal of biochemical and molecular toxicology.

Inflammation and Drug Idiosyncrasy—Is There a Connection?

J. Luyendyk, P. Ganey, R. Roth, 2003, Journal of Pharmacology and Experimental Therapeutics.

Early growth response factor-1 limits biliary fibrosis in a model of xenobiotic-induced cholestasis in mice.

B. Copple, J. Luyendyk, B. Sullivan, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Efficient megakaryopoiesis and platelet production require phospholipid remodeling and PUFA uptake through CD36

P. Meikle, A. Murphy, J. Luyendyk, 2023, bioRxiv.

Comparison of TNFα to Lipopolysaccharide as an Inflammagen to Characterize the Idiosyncratic Hepatotoxicity Potential of Drugs: Trovafloxacin as an Example

J. Waring, J. Luyendyk, E. Blomme, 2010, International journal of molecular sciences.

Microarray Analysis of Lipopolysaccharide Potentiation of Trovafloxacin-Induced Liver Injury in Rats Suggests a Role for Proinflammatory Chemokines and Neutrophils

J. Waring, J. Luyendyk, E. Blomme, 2006, Journal of Pharmacology and Experimental Therapeutics.

Novel genetic regulators of fibrinogen synthesis identified by an in vitro experimental platform.

A. Morrison, J. Luyendyk, J. Huffman, 2022, Journal of thrombosis and haemostasis : JTH.

Von Willebrand factor deficiency reduces liver fibrosis in mice

J. Luyendyk, A. Kopec, N. Joshi, 2017, Toxicology and applied pharmacology.

Neutrophil Interaction with the Hemostatic System Contributes to Liver Injury in Rats Cotreated with Lipopolysaccharide and Ranitidine

J. Luyendyk, P. Ganey, R. Roth, 2007, Journal of Pharmacology and Experimental Therapeutics.

Liver fibrosis is driven by protease‐activated receptor‐1 expressed by hepatic stellate cells in experimental chronic liver injury

B. Copple, J. Luyendyk, K. Williams, 2020, Research and practice in thrombosis and haemostasis.

Introduction to the Liver: Functional Anatomy and Response to Toxicants ☆

R. McCuskey, J. Luyendyk, I. Sipes, 2018 .

Coagulation‐driven platelet activation reduces cholestatic liver injury and fibrosis in mice

B. Copple, J. Luyendyk, A. Kopec, 2015, Journal of thrombosis and haemostasis : JTH.

Gene expression analysis points to hemostasis in livers of rats cotreated with lipopolysaccharide and ranitidine.

Lyle D Burgoon, Timothy R Zacharewski, William B Mattes, 2004, Toxicological sciences : an official journal of the Society of Toxicology.

Augmentation of aflatoxin B1 hepatotoxicity by endotoxin: involvement of endothelium and the coagulation system.

B. Copple, J. Luyendyk, P. Ganey, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Systemic inflammation and disorders of hemostasis in the AD-ACLF syndrome

J. Luyendyk, T. Lisman, 2021, Journal of Hepatology.

Inhibition of PAR-4 and P2Y12 receptor-mediated platelet activation produces distinct hepatic pathologies in experimental xenobiotic-induced cholestatic liver disease.

J. Luyendyk, A. Kopec, N. Joshi, 2016, Toxicology.

Hypofibrinogenemia with preserved hemostasis and protection from thrombosis in mice with a Fga truncation mutation.

David S. Paul, J. Luyendyk, T. Ugarova, 2021, Blood.

Unique Gene Expression and Hepatocellular Injury in the Lipopolysaccharide-Ranitidine Drug Idiosyncrasy Rat Model : Comparison with Famotidine

J. Luyendyk, P. Ganey, B. Car, 2006 .

Turning clots into stardust: nanoparticles stay on target.

J. Luyendyk, 2023, Journal of thrombosis and haemostasis : JTH.

Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy.

H. Jaeschke, B. Copple, J. Luyendyk, 2014, Journal of hepatology.

PAR-1 contributes to the innate immune response during viral infection.

D. Kirchhofer, J. Luyendyk, N. Mackman, 2013, The Journal of clinical investigation.

Unique gene expression and hepatocellular injury in the lipopolysaccharide-ranitidine drug idiosyncrasy rat model: comparison with famotidine.

J. Luyendyk, P. Ganey, B. Car, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

Contribution of Host-Derived Tissue Factor to Tumor Neovascularization

J. Rak, J. Luyendyk, N. Mackman, 2008, Arteriosclerosis, thrombosis, and vascular biology.

Direct Amplification of TF (Tissue Factor).

H. Jaeschke, J. Luyendyk, M. Olyaee, 2019, Arteriosclerosis, thrombosis, and vascular biology.

Direct amplification of tissue factor:factor VIIa procoagulant activity by bile acids drives intrahepatic coagulation

J. Luyendyk, M. Olyaee, A. Kopec, 2019 .

RNA Sequencing Identifies Novel Translational Biomarkers of Kidney Fibrosis.

John N. Hutchinson, U. Kusebauch, Christopher L Moss, 2016, Journal of the American Society of Nephrology : JASN.

Therapeutic administration of the direct thrombin inhibitor argatroban reduces hepatic inflammation in mice with established fatty liver disease.

B. Copple, J. Luyendyk, Karen M. Kassel, 2012, The American journal of pathology.

Monocyte chemoattractant protein-1-deficiency does not affect steatosis or inflammation in livers of mice fed a methionine-choline-deficient diet

O. Tawfik, J. Luyendyk, Karen M. Kassel, 2010, Laboratory Investigation.

Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet.

J. Luyendyk, Karen M. Kassel, B. Sullivan, 2011, The American journal of pathology.

Mice with hepatocyte-specific FXR deficiency are resistant to spontaneous but susceptible to cholic acid-induced hepatocarcinogenesis.

O. Tawfik, J. Luyendyk, G. Guo, 2016, American journal of physiology. Gastrointestinal and liver physiology.

Microarray Analysis of Lipopolysaccharide Potentiation of Trovafloxacin-Induced Liver Injury in Rats Suggests a Role for Proinflammatory Chemokines and Neutrophils

J. Waring, J. Luyendyk, E. Blomme, 2006, Journal of Pharmacology and Experimental Therapeutics.

Mechanisms of STAT3 activation in the liver of FXR knockout mice.

O. Tawfik, J. Luyendyk, Karen M. Kassel, 2013, American journal of physiology. Gastrointestinal and liver physiology.

COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARδ activation

S. Dey, M. Ghosh, Haibin Wang, 2007, Journal of Experimental Medicine.

Abstract 42: Monocyte Tissue Factor-Dependent Activation of Coagulation in Hypercholesterolemic Mice and Monkeys Is Inhibited by Simvastatin

D. Johns, D. Kirchhofer, J. Luyendyk, 2012, Arteriosclerosis, Thrombosis, and Vascular Biology.

Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin.

D. Kirchhofer, J. Luyendyk, N. Mackman, 2012, The Journal of clinical investigation.

Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice.

Mitchell R. McGill, H. Jaeschke, J. Luyendyk, 2015, Blood.

Good cells go bad: immune dysregulation in the transition from acute liver injury to liver failure after acetaminophen overdose.

B. Copple, J. Luyendyk, Elena Morozova, 2023, Drug metabolism and disposition: the biological fate of chemicals.

Interleukin-10 disrupts liver repair in acetaminophen-induced acute liver failure

B. Copple, J. Luyendyk, K. Roth, 2023, Frontiers in immunology.

The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis.

P. Weinreb, S. Violette, J. Luyendyk, 2010, The American journal of pathology.

Inhibition of PAR-4 and P2Y12 receptor-mediated platelet activation produces distinct hepatic pathologies in experimental xenobiotic-induced cholestatic liver disease.

J. Luyendyk, A. Kopec, N. Joshi, 2016, Toxicology.

Von Willebrand factor exerts hepatoprotective effects in acute but not chronic cholestatic liver injury in mice.

J. Luyendyk, A. Kopec, D. Groeneveld, 2021, Toxicology.