J. Gutkind

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MAP kinases and the control of nuclear events

A. Turjanski, J. Vaqué, J. Gutkind, 2007, Oncogene.

Regulation of mitogen-activated protein kinases by G-protein-coupled receptors.

J. Gutkind, M. Chiariello, 2002, Methods in enzymology.

Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells.

E. Kremmer, W. Kolch, H. Mischak, 1996, Genes & development.

Cell growth control by G protein-coupled receptors: from signal transduction to signal integration

J. Gutkind, J Silvio Gutkind, J. Gutkind, 1998, Oncogene.

Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.

G. Merlino, J. Vaqué, J. Gutkind, 2014, Cancer cell.

Regulation of Mitogen-Activated Protein Kinase Signaling Networks by G Protein-Coupled Receptors

J. Gutkind, 2000, Science's STKE.

Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

A. Klein-Szanto, H. Yagi, R. Parsons, 2010, Molecular cell.

Proteomic profiling of the cancer microenvironment by antibody arrays

L. Liotta, P. Munson, V. Prabhu, 2001, Proteomics.

Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes.

J. Gutkind, A. Molinolo, A. Sodhi, 2003, Cancer cell.

The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer

S. Seshagiri, T. Handel, I. Kufareva, 2013, Nature Reviews Cancer.

G-protein-coupled receptors and signaling networks: emerging paradigms.

J. Gutkind, M. Marinissen, 2001, Trends in pharmacological sciences.

Illuminating the Onco-GPCRome: Novel G protein–coupled receptor-driven oncocrine networks and targets for cancer immunotherapy

Robert B. Russell, Pablo Tamayo, Olivier Harismendy, 2019, The Journal of Biological Chemistry.

Human tumor-associated viruses and new insights into the molecular mechanisms of cancer

J. Gutkind, D. Martin, Daniel Martin, 2008, Oncogene.

PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets

R. Nussenblatt, Yihai Cao, J. Gutkind, 2010, Proceedings of the National Academy of Sciences.

Cross talk between the bombesin neuropeptide receptor and Sonic hedgehog pathways in small cell lung carcinoma

G. Alí, G. Fontanini, M. Santoro, 2014, Oncogene.

A Systems Genetics Approach Identifies CXCL14, ITGAX, and LPCAT2 as Novel Aggressive Prostate Cancer Susceptibility Genes

Ying Hu, Suiyuan Zhang, Jonathan Andreas, 2014, PLoS genetics.

Integrin function: molecular hierarchies of cytoskeletal and signaling molecules

K. Yamada, J. Gutkind, S. Akiyama, 1995, The Journal of cell biology.

Control of the differentiation of regulatory T cells and TH17 cells by the DNA-binding inhibitor Id3

Jun Li, Takashi Maruyama, Baojun Zhang, 2011, Nature Immunology.

Deletion or substitution within the alpha platelet-derived growth factor receptor kinase insert domain: effects on functional coupling with intracellular signaling pathways

M. Ruggiero, S. Aaronson, T. Matsui, 1991 .

Expression of the fgr protooncogene product as a function of myelomonocytic cell maturation

K. Robbins, J. Gutkind, S. Katamine, 1989, The Journal of cell biology.

Potent transforming activity of the small GTP‐binding protein Rit in NIH 3T3 cells: evidence for a role of a p38γ‐dependent signaling pathway

J. Gutkind, H. Miyazaki, K. Sakabe, 2002, FEBS letters.

Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells

J. Gutkind, S. Hermouet, And, 1992, Molecular and cellular biology.

TRAIL induces apoptosis in oral squamous carcinoma cells: a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5

Baolin Zhang, Jun-jie Chen, J. Gutkind, 2013, Oncotarget.

Deletion of the COOH Terminus Converts the ST5 p70 Protein from an Inhibitor of RAS Signaling to an Activator with Transforming Activity in NIH-3T3 Cells*

J. Gutkind, M. Majidi, J. Lichy, 2000, The Journal of Biological Chemistry.

Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway.

J. Gutkind, M. Marinissen, M. Chiariello, 2001, Genes & development.

Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation

N. Qutob, J. Gartner, V. Hill, 2014, The Journal of investigative dermatology.

The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor promotes endothelial cell survival through the activation of Akt/protein kinase B.

J. Gutkind, A. Sodhi, E. Mesri, 2001, Cancer research.

Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer

J. Gutkind, A. Sakurai, C. Doçi, 2011, Cell Research.

Accumulation of the SET protein in HEK293T cells and mild oxidative stress: cell survival or death signaling

E. Tajara, J. Gutkind, C. Pestana, 2011, Molecular and Cellular Biochemistry.

A Novel Role for Phosphatidylinositol 3-Kinase β in Signaling from G Protein-coupled Receptors to Akt*

J. Gutkind, S. Fukuhara, C. Murga, 2000, The Journal of Biological Chemistry.

Genetic variants affecting equivalent protein family positions reflect human diversity

R. Russell, Francesco Raimondi, J. Gutkind, 2017, Scientific Reports.

Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models

E. Tajara, J. Gutkind, L. Greene, 2014, Molecular Cancer.

Longitudinal Imaging Studies of Tumor Microenvironment in Mice Treated with the mTOR Inhibitor Rapamycin

James B. Mitchell, S. Matsumoto, J. Gutkind, 2012, PloS one.

Cbl-b regulates the CD28 dependence of T-cell activation

E. Shevach, J. Gutkind, S. Fukuhara, 2000, Nature.

Estrogen receptor alpha mediates progestin-induced mammary tumor growth by interacting with progesterone receptors at the cyclin D1/MYC promoters.

J. Vaqué, J. Gutkind, A. Molinolo, 2012, Cancer research.

A Common Requirement for the Catalytic Activity and Both SH2 Domains of SHP-2 in Mitogen-activated Protein (MAP) Kinase Activation by the ErbB Family of Receptors

J. Dixon, D. Salomon, J. Gutkind, 1998, The Journal of Biological Chemistry.

Requirement of phosphatidylinositol-3 kinase for activation of JNK/SAPKs by PDGF.

J. Gutkind, A. Kazlauskas, M. Heidaran, 1997, Biochemical and biophysical research communications.

Illuminating G-Protein-Coupling Selectivity of GPCRs

R. Russell, Francesco Raimondi, J. Gutkind, 2019, Cell.

PRECOG: PREdicting COupling probabilities of G-protein coupled receptors

R. Russell, Francesco Raimondi, J. Gutkind, 2019, Nucleic Acids Res..

PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis.

E. Hirsch, J. Gutkind, R. Wetzker, 2011, Cancer cell.

The small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation.

J. Gutkind, S. Montaner, O. Coso, 1997, Proceedings of the National Academy of Sciences of the United States of America.

A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells.

J. Gutkind, N. Xu, N. Xu, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Potent Activation of RhoA by Gαq and Gq-coupled Receptors*

J. Gutkind, H. Miyazaki, H. Chikumi, 2002, Journal of Biological Chemistry.

Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes.

M. Brann, K. Robbins, J. Gutkind, 1991, Proceedings of the National Academy of Sciences of the United States of America.

VE-cadherin and claudin-5: it takes two to tango

J. Gutkind, J. Gavard, J. Gutkind, 2008, Nature Cell Biology.

Signaling from E-cadherins to the MAPK Pathway by the Recruitment and Activation of Epidermal Growth Factor Receptors upon Cell-Cell Contact Formation*

J. Gutkind, S. Pece, 2000, The Journal of Biological Chemistry.

Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia.

J. Gutkind, V. Patel, J. Gavard, 2008, Developmental cell.

Isoproterenol inhibits fibroblast growth factor-2-induced growth of renal epithelial cells

J. Gutkind, E. Izevbigie, P. Ray, 2000, Pediatric Nephrology.

The P34G Mutation Reduces the Transforming Activity of K-Ras and N-Ras in NIH 3T3 Cells but Not of H-Ras*

Á. Juarranz, J. Gutkind, N. Martínez, 2004, Journal of Biological Chemistry.

The small GTPase Rac1 links the Kaposi sarcoma-associated herpesvirus vGPCR to cytokine secretion and paracrine neoplasia.

J. Gutkind, A. Sodhi, A. Barac, 2004, Blood.

Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling

Amber N. Stratman, S. Pezoa, G. Davis, 2018, Nature Communications.

CXCL8/IL8 Stimulates Vascular Endothelial Growth Factor (VEGF) Expression and the Autocrine Activation of VEGFR2 in Endothelial Cells by Activating NFκB through the CBM (Carma3/Bcl10/Malt1) Complex*

J. Gutkind, Daniel Martin, R. Galisteo, 2009, Journal of Biological Chemistry.

Focal Adhesion Kinase (FAK)-Hippo/YAP transduction signaling mediates the stimulatory effects exerted by S100A8/A9-RAGE system in triple-negative breast cancer (TNBC)

J. Gutkind, A. Belfiore, F. Cirillo, 2022, Journal of experimental & clinical cancer research : CR.

The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.

J. Gutkind, V. Patel, A. Sodhi, 2000, Cancer research.

Role of Mitogen-activated Protein Kinases and c-Jun/AP-1 trans-Activating Activity in the Regulation of Protease mRNAs and the Malignant Phenotype in NIH 3T3 Fibroblasts*

J. Gutkind, R. Schultz, S. Silberman, 1999, The Journal of Biological Chemistry.

Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1

J. Gutkind, M. Zhalnina, L. Avramova, 2022, The Journal of biological chemistry.

J. Gutkind, V. Patel, A. Sodhi, 2000, Cancer research.

The Kaposi’s Sarcoma-associated Herpes Virus G Protein-coupled Receptor Up- Regulates Vascular Endothelial Growth Factor Expression and Secretion through Mitogen-activated Protein Kinase and p38 Pathways Acting on Hypoxia-inducible Factor 1a

J. Gutkind, V. Patel, A. Sodhi, 2000 .

Hypoxia-inducible Factor 1 Mitogen-activated Protein Kinase and p 38 Pathways Acting on Growth Factor Expression and Secretion through Protein-coupled Receptor UpRegulates Vascular Endothelial The Kaposi ' s Sarcoma-associated Herpes Virus G Updated

J. Gutkind, V. Patel, A. Sodhi, 2000 .

Induction of apoptosis in head‐and‐neck squamous carcinoma cells by γ‐irradiation and bleomycin is p53‐independent

W. A. Yeudall, W. Yeudall, J. Ensley, 2000, International journal of cancer.

Improved clearance during treatment of HPV-positive head and neck cancer through mTOR inhibition.

J. Gutkind, A. Molinolo, John H. Lee, 2013, Neoplasia.

Multiple PPPS/TP motifs act in a combinatorial fashion to transduce Wnt signaling through LRP6

B. Williams, J. Gutkind, Todd R. Palmby, 2008, FEBS letters.

A new twist for the tumour suppressor hamartin

J. Gutkind, S. Fukuhara, 2000, Nature Cell Biology.

Gastrin Stimulates Cyclooxygenase-2 Expression in Intestinal Epithelial Cells through Multiple Signaling Pathways

J. Gutkind, C. Townsend, Ji-Zhong Cheng, 2002, The Journal of Biological Chemistry.

Semaphorin 3E Initiates Antiangiogenic Signaling through Plexin D1 by Regulating Arf6 and R-Ras

H. Yagi, J. Gutkind, Fan Zhang, 2010, Molecular and Cellular Biology.

Interleukin-21 expression and its association with proinflammatory cytokines in untreated chronic periodontitis patients.

J. Vaqué, J. Gutkind, L. Abusleme, 2012, Journal of periodontology.

Activation of Ras and Rho GTPases and MAP Kinases by G-protein-coupled receptors.

P. Crespo, J. Vaqué, J. Gutkind, 2010, Methods in molecular biology.

Assembly and patterning of the vascular network of the vertebrate hindbrain

J. Gutkind, B. L. Roman, B. Weinstein, 2011, Development.

Exploiting PI3K/mTOR signaling to accelerate epithelial wound healing.

J. Gutkind, R. Castilho, C. Squarize, 2013, Oral diseases.

Exploiting PI 3 K / mTOR signaling to accelerate epithelial wound healing

J. Gutkind, R. Castilho, C. Squarize, 2013 .

Phosphatidylinositol-4-phosphate 5-Kinase and GEP100/Brag2 Protein Mediate Antiangiogenic Signaling by Semaphorin 3E-Plexin-D1 through Arf6 Protein*

E. Chavakis, J. Gutkind, J. Donaldson, 2011, The Journal of Biological Chemistry.

Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release.

K. Robbins, J. Gutkind, M. Benhamou, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Progressive Tumor Formation in Mice with Conditional Deletion of TGF- B Signaling in Head and Neck Epithelia Is Associated with Activation of the PI3K/Akt Pathway Molecular Biology, Pathobiology, and

L. Wakefield, K. Flanders, A. Kulkarni, 2009 .

Dual effect of beta-adrenergic receptors on mitogen-activated protein kinase. Evidence for a beta gamma-dependent activation and a G alpha s-cAMP-mediated inhibition.

P. Crespo, T. Cachero, J. Gutkind, 1995, The Journal of biological chemistry.

G12-G13–LARG–mediated signaling in vascular smooth muscle is required for salt-induced hypertension

Stefan Offermanns, Zoltán Benyó, Stefan Gorbey, 2008, Nature Medicine.

Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.

G. Lienhard, M. White, S. Aaronson, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Selective Activation of Effector Pathways by Brain-specific G Protein β5*

W. Simonds, J. Gutkind, Chunghee Lee, 1996, The Journal of Biological Chemistry.

Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction

M. Ruggiero, S. Aaronson, J. Gutkind, 1991, Molecular and cellular biology.

Angiopoietin-1 Induces Krüppel-like Factor 2 Expression through a Phosphoinositide 3-Kinase/AKT-dependent Activation of Myocyte Enhancer Factor 2*♦

T. Kodama, A. Fukamizu, N. Mochizuki, 2009, Journal of Biological Chemistry.

Phosphoinositide 3-Kinase γ Is a Mediator of Gβγ-dependent Jun Kinase Activation*

J. Gutkind, R. Wetzker, M. Lopez-Ilasaca, 1998, The Journal of Biological Chemistry.

Phosphoinositide 3-kinase gamma is a mediator of Gbetagamma-dependent Jun kinase activation.

J. Gutkind, R. Wetzker, M. Lopez-Ilasaca, 1998, Journal of Biological Chemistry.

Differential inhibitor of Gbetagamma signaling to AKT and ERK derived from phosducin-like protein: effect on sphingosine 1-phosphate-induced endothelial cell migration and in vitro angiogenesis.

J. Gutkind, J. Vázquez-Prado, G. Reyes-Cruz, 2009, The Journal of biological chemistry.

Erratum: G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator

E. Cesarman, J. Gutkind, M. Gershengorn, 1998, Nature.

Faculty Opinions recommendation of Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation.

J. Gutkind, J. Gutkind, 2008 .

Identification of distinct populations of PI-3 kinase activity following T-cell activation.

P. Thompson, K. Robbins, J. Gutkind, 1992, Oncogene.

CXCL8/IL8 Stimulates Vascular Endothelial Growth Factor (VEGF) Expression and the Autocrine Activation of VEGFR2 in Endothelial Cells by Activating NFκB through the CBM (Carma3/Bcl10/Malt1) Complex*

J. Gutkind, Daniel Martin, R. Galisteo, 2009, Journal of Biological Chemistry.

PLC-γ activation is required for PDGF-βR-mediated mitogenesis and monocytic differentiation of myeloid progenitor cells

J. Gutkind, A. Kazlauskas, Weiqun Li, 1997, Oncogene.

The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis.

S. Narumiya, O. Bernard, J. Gutkind, 2004, Molecular cell.

Transforming G Protein-coupled Receptors Potently Activate JNK (SAPK)

J. Woodgett, J. Gutkind, J. Kyriakis, 1995, The Journal of Biological Chemistry.

Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway.

P. Crespo, J. Gutkind, J. Troppmair, 1994, The Journal of biological chemistry.

Heparin inhibits angiotensin II-induced vasoconstriction on isolated mouse mesenteric resistance arteries through Rho-A- and PKA-dependent pathways.

J. Gutkind, J. Das, P. Ray, 2013, Vascular pharmacology.

Signalling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKs): evidence for a divergence of the ERKs and JNKs pathways induced by Ret

M. Santoro, A. Fusco, J. Gutkind, 1998, Oncogene.

Regulation of cyclin-dependent kinase (Cdk) 2 Thr-160 phosphorylation and activity by mitogen-activated protein kinase in late G1 phase.

J. Gutkind, M. Chiariello, E. Gomez, 2000, The Biochemical journal.

IL‐4 activates a distinct signal transduction cascade from IL‐3 in factor‐dependent myeloid cells.

J. Gutkind, Ling-mei Wang, A. Keegan, 1992, The EMBO journal.

1 Alpha,25-dihydroxyvitamin D3 and its TX527 analog inhibit the growth of endothelial cells transformed by Kaposi sarcoma-associated herpes virus G protein-coupled receptor in vitro and in vivo.

J. Gutkind, R. Bouillon, R. Boland, 2010, Endocrinology.

PLC-gamma activation is required for PDGF-betaR-mediated mitogenesis and monocytic differentiation of myeloid progenitor cells.

J. Gutkind, A. Kazlauskas, J. Pierce, 1997, Oncogene.

Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.

M. Barbacid, P. Crespo, D. Aaronson, 1996, Oncogene.

RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock

N. Mochizuki, J. Gutkind, R. Adams, 2015, Nature Communications.

Role of GRB2‐associated binder 1 in epidermal growth factor receptor‐induced signaling in head and neck squamous cell carcinoma

J. Gutkind, J. Cools, D. Martin, 2013, International journal of cancer.

Signaling from G Protein-coupled Receptors to the c-jun Promoter Involves the MEF2 Transcription Factor

J. Gutkind, J. Lacal, R. Prywes, 1997, The Journal of Biological Chemistry.

Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway

J. Gutkind, R. Masgrau, C. Eichel-Streiber, 2003, Neuropharmacology.

Fc epsilon RI-induced protein tyrosine phosphorylation of pp72 in rat basophilic leukemia cells (RBL-2H3). Evidence for a novel signal transduction pathway unrelated to G protein activation and phosphatidylinositol hydrolysis.

K. Robbins, J. Gutkind, M. Benhamou, 1992, The Journal of biological chemistry.

Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6

J. Chiorini, J. Gutkind, M. Weller, 2010, Nature Medicine.

Insights into β2‐adrenergic receptor binding from structures of the N‐terminal lobe of ARRDC3

J. Hurley, J. Gutkind, M. O'Hayre, 2014, Protein science : a publication of the Protein Society.

The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor as a therapeutic target for the treatment of Kaposi's sarcoma.

J. Gutkind, A. Sodhi, S. Montaner, 2006, Cancer research.

Thrombin-dependent association of phosphatidylinositol-3 kinase with p60c-src and p59fyn in human platelets

P. Lacal, K. Robbins, J. Gutkind, 1990, Molecular and cellular biology.

A new G(q)-initiated MAPK signaling pathway in the heart.

J. Gutkind, S. Offermanns, 2009, Developmental cell.

The actin domain of Gardner-Rasheed feline sarcoma virus inhibits kinase and transforming activities

K. Robbins, J. Gutkind, T. Kawakami, 1989, Journal of virology.

J. Gutkind, V. Patel, A. Sodhi, 2000, Cancer research.

Circulating Fibroblast Growth Factor-2, HIV-Tat, and Vascular Endothelial Cell Growth Factor-A in HIV-Infected Children with Renal Disease Activate Rho-A and Src in Cultured Renal Endothelial Cells

J. Gutkind, J. Das, P. Ray, 2016, PloS one.

Deletion or substitution within the alpha platelet-derived growth factor receptor kinase insert domain: effects on functional coupling with intracellular signaling pathways

T. Matsui, M. Ruggiero, S. Aaronson, 1991, Molecular and cellular biology.

Cross-Desensitization and Cointernalization of H1 and H2 Histamine Receptors Reveal New Insights into Histamine Signal Integration

J. Gutkind, C. Notcovich, C. Shayo, 2013, Molecular Pharmacology.

Melanoma cell lysate induces CCR7 expression and in vivo migration to draining lymph nodes of therapeutic human dendritic cells

J. Gutkind, V. Patel, N. Dutzan, 2014, Immunology.

Differential inhibitor of Gbetagamma signaling to AKT and ERK derived from phosducin-like protein: effect on sphingosine 1-phosphate-induced endothelial cell migration and in vitro angiogenesis.

J. Gutkind, J. Vázquez-Prado, G. Reyes-Cruz, 2009, The Journal of biological chemistry.

Does dysregulated expression of a deregulated viral GPCR trigger Kaposi's sarcomagenesis?

J. Gutkind, A. Sodhi, S. Montaner, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Oncotargeting G proteins: The Hippo in the room

J. Gutkind, Xiaodong Feng, Qianming Chen, 2014, Oncotarget.

P-Rex1 links mTOR signaling to Rac activation and cell migration

J. Gutkind, H. Rosenfeldt, J. Vázquez-Prado, 2007 .

Overexpression of mammalian protein kinase C-zeta does not affect the growth characteristics of NIH 3T3 cells.

H. Mischak, P. Crespo, J. Gutkind, 1995, Biochemical and biophysical research communications.

The kaposi’s sarcoma associated herpesvirus: a model for viral oncogenesis

J. Gutkind, A. Sodhi, S. Montaner, 2002, Revista de Oncología.

The non-catalytic domain of ras-GAP inhibits transformation induced by G protein coupled receptors.

F. McCormick, J. Gutkind, N. Xu, 1994, Oncogene.

A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes

T. Ley, D. Link, P. Lacal, 1991, Molecular and cellular biology.

Effector domain mutants of Rho dissociate cytoskeletal changes from nuclear signaling and cellular transformation

J. Gutkind, B. Katz, H. Teramoto, 1998, Oncogene.

ACCELERATED COMMUNICATION : G a s activates Cdc 42 via PDZ-RhoGEF

J. Gutkind, J. Vázquez-Prado, I. García-Jiménez, 2020 .

Signaling by G protein coupled receptors and G proteins: a perspective

J. Gutkind, N. Dhanasekaran, 2001, Oncogene.

Accumulation of the SET protein in HEK293T cells and mild oxidative stress: cell survival or death signaling

E. Tajara, J. Gutkind, C. Pestana, 2012, Molecular and Cellular Biochemistry.

Autoradiographic localization of osteogenin binding sites in cartilage and bone during rat embryonic development.

S. Vukicevic, A. Reddi, V. Paralkar, 1990, Developmental biology.

The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG

N. Ahn, H. Vikis, K. Guan, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Plexin B Regulates Rho through the Guanine Nucleotide Exchange Factors Leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF*

J. Gutkind, J. Vázquez-Prado, V. Perrot, 2002, The Journal of Biological Chemistry.

Regulation of reactive-oxygen-species generation in fibroblasts by Rac1.

V. Ferrans, K. Irani, J. Gutkind, 1996, The Biochemical journal.

Neuronal Nuclear Organization Is Controlled by Cyclin-Dependent Kinase 5 Phosphorylation of Ras Guanine Nucleotide Releasing Factor-1

A. Kulkarni, J. Gutkind, Wu Ma, 2006, Neurosignals.

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

S. Spiegel, J. Gutkind, G. Pirianov, 1996, Nature.

Cyclooxygenase-2 and Colorectal Cancer Chemoprevention: The β-Catenin Connection

J. Gutkind, M. Castellone, H. Teramoto, 2006 .

Activation of transforming G protein-coupled receptors induces rapid tyrosine phosphorylation of cellular proteins, including p125FAK and the p130 v-src substrate.

K. Robbins, J. Gutkind, 1992, Biochemical and biophysical research communications.

G-protein-coupled receptors and cancer

J. Gutkind, J. Silvio Gutkind, Robert T. Dorsam, 2007, Nature Reviews Cancer.

Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors

K. Yamada, J. Gutkind, H. Teramoto, 1996, The Journal of cell biology.

A Role for the p38 Mitogen-activated Protein Kinase Pathway in the Transcriptional Activation of p53 on Genotoxic Stress by Chemotherapeutic Agents

Y. Taya, J. Gutkind, J. Rojas, 2000 .

Activation of Akt/Protein Kinase B by G Protein-coupled Receptors

A. Cuadrado, J. Gutkind, C. Murga, 1998, The Journal of Biological Chemistry.

G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator

E. Cesarman, J. Gutkind, E. Mesri, 1998, Nature.

mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.

James B. Mitchell, Vyomesh Patel, J. Gutkind, 2012, Cell stem cell.

Transforming G protein-coupled receptors transduce potent mitogenic signals in NIH 3T3 cells independent on cAMP inhibition or conventional protein kinase C.

M. Brann, J. Gutkind, G. Kalinec, 1993, Oncogene.

Signals and Receptors.

C. Heldin, J. Gutkind, Benson Lu, 2016, Cold Spring Harbor perspectives in biology.

Thrombin Protease-activated Receptor-1 Signals through Gq- and G13-initiated MAPK Cascades Regulating c-Jun Expression to Induce Cell Transformation*

M. Simon, Melvin I. Simon, J. Gutkind, 2003, Journal of Biological Chemistry.

A Network of Mitogen-Activated Protein Kinases Links G Protein-Coupled Receptors to the c-jun Promoter: a Role for c-Jun NH2-Terminal Kinase, p38s, and Extracellular Signal-Regulated Kinase 5

J. Gutkind, M. Marinissen, M. Chiariello, 1999, Molecular and Cellular Biology.

Transforming G protein-coupled receptors block insulin and ras-induced adipocytic differentiation in 3T3-L1 cells: evidence for a PKC and MAP kinase independent pathway.

P. Crespo, D. Aaronson, J. Gutkind, 1998, Biochemical and biophysical research communications.

Gα12- and Gα13-Subunits of Heterotrimeric G-Proteins A Novel Family of Oncogenes

J. Gutkind, O. Coso, N. Xu, 1998 .

Dual Effect of β-Adrenergic Receptors on Mitogen-activated Protein Kinase

P. Crespo, T. Cachero, J. Gutkind, 1995, The Journal of Biological Chemistry.

Sonic Hedgehog in SCLC

J. Gutkind, M. Castellone, M. Laukkanen, 2015, Aging.

A role for p38 MAPK in head and neck cancer cell growth and tumor‐induced angiogenesis and lymphangiogenesis

J. Gutkind, A. Molinolo, J. Basile, 2014, Molecular oncology.

Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ

P. Crespo, J. Gutkind, R. Wetzker, 1997, Science.

The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades*

J. Gutkind, 1998, The Journal of Biological Chemistry.

Translocation of the FGR protein-tyrosine kinase as a consequence of neutrophil activation.

K. Robbins, J. Gutkind, K C Robbins, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Cancer Therapy : Preclinical Chemopreventive and Chemotherapeutic Actions of mTOR Inhibitor in Genetically De fi ned Head and Neck Squamous Cell Carcinoma Mouse Model

A. Kulkarni, Y. Bian, J. Gutkind, 2012 .

Global gene expression profiles of human head and neck squamous carcinoma cell lines

Vyomesh Patel, In-Sun Chu, Myung Hee Park, 2004, International journal of cancer.

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

P. Crespo, J. Gutkind, M. Chiariello, 1995, Cell.

Parasympathetic Innervation Maintains Epithelial Progenitor Cells During Salivary Organogenesis

M. P. Hoffman, R. Butcher, Takaaki Hirotsu, 2010, Science.

Head and Neck Cancer and the PI3K/Akt/mTOR Signaling Network: Novel Molecular Targeted Therapies

J. Gutkind, V. Patel, A. Molinolo, 2011 .

Dysregulated molecular networks in head and neck carcinogenesis.

J. Gutkind, V. Patel, A. Molinolo, 2009, Oral oncology.

Identification of H-Ras, RhoA, Rac1 and Cdc42 responsive genes

N. Lee, J. Gutkind, M. Castellone, 2003, Oncogene.

A C-terminal Mutant of the G Protein β Subunit Deficient in the Activation of Phospholipase C-β*

W. Simonds, J. Gutkind, O. Coso, 1996, The Journal of Biological Chemistry.

IKK epsilon kinase is crucial for viral G protein-coupled receptor tumorigenesis

J. Gutkind, Jae U. Jung, P. Feng, 2013, Proceedings of the National Academy of Sciences.

Molecular mechanisms deployed by virally encoded G protein-coupled receptors in human diseases.

R. Abagyan, I. Kufareva, J. Gutkind, 2013, Annual review of pharmacology and toxicology.

G-Protein-Coupled Receptors, Signal Fidelity, and Cell Transformation

J. Gutkind, Todd R. Palmby, H. Rosenfeldt, 2010 .

Kaposi's sarcoma virally encoded, G-protein-coupled receptor: a paradigm for paracrine transformation.

J. Gutkind, Daniel Martin, 2009, Methods in enzymology.

The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor.

E. Sausville, B. Manning, J. Gutkind, 2006, Cancer cell.

Viral hijacking of G-protein-coupled-receptor signalling networks

J. Gutkind, A. Sodhi, S. Montaner, 2004, Nature Reviews Molecular Cell Biology.

Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor.

E. Sausville, J. Gutkind, V. Patel, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Receptor Tyrosine Kinases Activate Canonical WNT/β-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct β-Catenin Phosphorylation

Lukas Balek, Marketa Kaucka, Ethylin Wang Jabs, 2012, PloS one.

Receptor Tyrosine Kinases Activate Canonical WNT/?-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct Beta-Catenin Phosphorylation

Lukas Balek, Marketa Kaucka, Ethylin Wang Jabs, 2012 .

Mitogen-Activated Protein Kinases Promote WNT/beta-CateninSignaling via Phosphorylation of LRP6

G. Schulte, A. Kozubík, W. Wilcox, 2011 .

Prostaglandin E2 Promotes Colon Cancer Cell Growth Through a Gs-Axin-ß-Catenin Signaling Axis

K. Druey, B. Williams, J. Gutkind, 2005, Science.

Signaling from the Small GTP-binding Proteins Rac1 and Cdc42 to the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway

J. Gutkind, T. Igishi, T. Miki, 1996, The Journal of Biological Chemistry.

Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer

W. Klapper, J. Gutkind, I. Alkatout, 2016, Oncotarget.

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

K. Schuebel, P. Crespo, J. Gutkind, 1997, Nature.

A Molecular Crosstalk between E-cadherin and EGFR Signaling Networks

J. Gutkind, J. Gavard, 2008 .

Breast cancer incidence in U.S. radiologic technologists

J. Gu, Xifeng Wu, Q. Dong, 2006, Cancer.

Massively Parallel Sequencing Reveals an Accumulation of De Novo Mutations and an Activating Mutation of LPAR1 in a Patient with Metastatic Neuroblastoma

J. Khan, Jun S. Wei, P. Johansson, 2013, PloS one.

Plexin-B1 Utilizes RhoA and Rho Kinase to Promote the Integrin-dependent Activation of Akt and ERK and Endothelial Cell Motility*

J. Gutkind, J. Basile, J. Gavard, 2007, Journal of Biological Chemistry.

Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis.

J. Gutkind, J. Basile, R. M. Castilho, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Semaphorin 4D/Plexin-B1 Induces Endothelial Cell Migration through the Activation of PYK2, Src, and the Phosphatidylinositol 3-Kinase-Akt Pathway

K. Guan, J. Gutkind, J. Basile, 2005, Molecular and Cellular Biology.

Scaffold proteins dictate Rho GTPase-signaling specificity.

J. Gutkind, M. Marinissen, 2005, Trends in biochemical sciences.

Class IV Semaphorins Promote Angiogenesis by Stimulating Rho-Initiated Pathways through Plexin-B

K. Guan, J. Gutkind, T. Zhu, 2004, Cancer Research.

Leukemia‐associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G12 family to Rho

J. Gutkind, S. Fukuhara, Hiroki Chikumi, 2000, FEBS letters.

Inactivating Mutations in GNA13 and RHOA in Burkitt’s Lymphoma and Diffuse Large B cell Lymphoma: A Tumor Suppressor Function for the Gα13/RhoA Axis in B Cells

Khalid W. Kalim, I. Kufareva, J. Gutkind, 2015, Oncogene.

Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells

S. Millar, J. Gutkind, V. Patel, 2007, Oncogene.

Modulation of canonical Wnt signaling by the extracellular matrix component biglycan

J. Gutkind, M. Young, P. Robey, 2011, Proceedings of the National Academy of Sciences.

Reciprocal negative regulation between S100A7/psoriasin and β-catenin signaling plays an important role in tumor progression of squamous cell carcinoma of oral cavity

P. Watson, John Calvin Reed, S. Matsuzawa, 2008, Oncogene.

Regulation of gene expression by the small GTPase Rho through the ERK6 (p38γ) MAP kinase pathway

J. Gutkind, M. Marinissen, M. Chiariello, 2001 .

Multiple Mitogen-Activated Protein Kinase Signaling Pathways Connect the Cot Oncoprotein to the c-junPromoter and to Cellular Transformation

J. Gutkind, M. Marinissen, M. Chiariello, 2000, Molecular and Cellular Biology.

Signaling from G-Protein-Coupled Receptors to the Nucleus

J. Gutkind, S. Fukuhara, M. Marinissen, 2000 .

Human JIK, a Novel Member of the STE20 Kinase Family That Inhibits JNK and Is Negatively Regulated by Epidermal Growth Factor*

J. Gutkind, P. P. Di Fiore, E. Tassi, 1999, The Journal of Biological Chemistry.

A Human Suppressor of c-Jun N-terminal Kinase 1 Activation by Tumor Necrosis Factor α*

K. Jeang, J. Gutkind, D. Jin, 1997, The Journal of Biological Chemistry.

The pathway connecting m2 receptors to the nucleus involves small GTP-binding proteins acting on divergent MAP kinase cascades.

P. Crespo, J. Gutkind, H. Teramoto, 1997, Life sciences.

Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

P. Crespo, W. Simonds, J. Gutkind, 1994, Nature.

SDF‐1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis

J. Gutkind, Zhiyong Wang, R. Weigert, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A Role for a CXCR2/Phosphatidylinositol 3-Kinase γ Signaling Axis in Acute and Chronic Vascular Permeability

J. Gutkind, R. Weigert, Xuri Li, 2009, Molecular and Cellular Biology.

MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF.

J. Gutkind, A. Sodhi, S. Montaner, 2001, Biochemical and biophysical research communications.

Diverse biologic properties imparted by the c-fgr proto-oncogene.

K. Robbins, J. Gutkind, O. Sartor, 1992, The Journal of biological chemistry.

Profiling EGFR activity in head and neck squamous cell carcinoma by using a novel layered membrane Western blot technology.

M. Emmert-Buck, J. Gutkind, V. Patel, 2005, Oral oncology.

The Gα13-Rho Signaling Axis Is Required for SDF-1-induced Migration through CXCR4*

J. Gutkind, Daniel Martin, Wenfu Tan, 2006, Journal of Biological Chemistry.

NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell

A. Kulkarni, J. Gutkind, Zhi-Li Zhao, 2016, Scientific Reports.

Induction of ovarian cancer by defined multiple genetic changes in a mouse model system.

H. Varmus, S. Orsulic, Yi Li, 2002, Cancer cell.

P-Rex1 Links Mammalian Target of Rapamycin Signaling to Rac Activation and Cell Migration*

J. Gutkind, H. Rosenfeldt, J. Vázquez-Prado, 2007, Journal of Biological Chemistry.

Tyrosine Phosphorylation of the vav Proto-oncogene Product Links FcεRI to the Rac1-JNK Pathway*

K. Robbins, J. Gutkind, X. Bustelo, 1997, The Journal of Biological Chemistry.

SPECs, Small Binding Proteins for Cdc42*

D. Pirone, J. Gutkind, S. Fukuhara, 2000, The Journal of Biological Chemistry.

Regulation of p73 by c-Abl through the p38 MAP kinase pathway

J. Gutkind, R. Sánchez-Prieto, J. Servitja, 2002, Oncogene.

p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model.

A. Jubb, K. Hoeflich, J. Gutkind, 2012, Cancer research.

PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells

B. Monia, J. Gutkind, Y. Choi, 2002, Oncogene.

E-cadherin and Hakai: signalling, remodeling or destruction?

J. Gutkind, S. Pece, 2002, Nature Cell Biology.

Targeting the PI3 K-mTOR Signaling Circuitry in HPV-Associated Oral Malignancies: Novel Precision Molecular Therapies

J. Gutkind, C. Doçi, J. Gutkind, 2015 .

Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-κB

J. Gutkind, C. Murga, H. Teramoto, 2002, Oncogene.

Activation of the Protein Kinase Akt/PKB by the Formation of E-cadherin-mediated Cell-Cell Junctions

J. Gutkind, C. Murga, M. Chiariello, 1999, The Journal of Biological Chemistry.

Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gαq and Gα13 proteins

E. Kostenis, J. Gutkind, G. König, 2018, The Journal of Biological Chemistry.

Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.

P. Crespo, W. Simonds, J. Gutkind, 1994, Nature.

Mitogen-Activated Protein Kinases Promote WNT/β-Catenin Signaling via Phosphorylation of LRP6

Joshua Wolf, G. Schulte, A. Kozubík, 2010, Molecular and Cellular Biology.

Catalytic site mutations confer multiple states of G protein activation

Kevin M. Knight, Reid H. J. Olsen, B. Roth, 2023, Science Signaling.

Chemopreventive and Chemotherapeutic Actions of mTOR Inhibitor in Genetically Defined Head and Neck Squamous Cell Carcinoma Mouse Model

A. Kulkarni, Y. Bian, J. Gutkind, 2012, Clinical Cancer Research.

Rac1 Function Is Required for Src-induced Transformation

J. Gutkind, M. Marinissen, X. Bustelo, 2003, Journal of Biological Chemistry.

The Platelet-derived Growth Factor Controls c-myc Expression through a JNK- and AP-1-dependent Signaling Pathway*

M. Acunzo, J. Gutkind, R. Visconti, 2003, Journal of Biological Chemistry.

Loss of PTEN expression leading to high Akt activation in human multiple myelomas.

J. Gutkind, T. Miki, S. Pece, 2000, Blood.

A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors.

David J. Forsthoefel, A. Debant, M. Seeger, 2013, Molecular cell.

A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing GPCR-initiated mitogenic signals

David J. Forsthoefel, A. Debant, M. Seeger, 2013 .

CHAPTER 218 – G-Protein-Coupled Receptors, Cell Transformation, and Signal Fidelity

J. Gutkind, M. Marinissen, H. Rosenfeldt, 2003 .

RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?

J. Gutkind, S. Fukuhara, H. Chikumi, 2001, Oncogene.

The Wnt/β-catenin Signaling Circuitry in Head and Neck Cancer

J. Gutkind, R. M. Castilho, J. Gutkind, 2014 .

MPA-induced gene expression and stromal and parenchymal gene expression profiles in luminal murine mammary carcinomas with different hormonal requirements

Jason I. Herschkowitz, C. Perou, J. Gutkind, 2011, Breast Cancer Research and Treatment.

Augmented Wnt Signaling in a Mammalian Model of Accelerated Aging

C. Kuo, Jichun Chen, D. Malide, 2007, Science.

Direct Interaction of p21-Activated Kinase 4 with PDZ-RhoGEF, a G Protein-linked Rho Guanine Exchange Factor*

J. Gutkind, Yi Zheng, J. Basile, 2004, Journal of Biological Chemistry.

Identification and Characterization of a Novel Ste20/Germinal Center Kinase-related Kinase, Polyploidy-associated Protein Kinase*

C. Hanson, J. Gutkind, S. Ruscetti, 2003, The Journal of Biological Chemistry.

Hypoxia-induced energy stress inhibits the mTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma.

J. Gutkind, A. Schneider, Rania Younis, 2008, Neoplasia.

Phosphorylation of c-Fos by Members of the p38 MAPK Family

D. Hochbaum, J. Gutkind, M. Marinissen, 2005, Journal of Biological Chemistry.

VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE-cadherin

J. Gutkind, Julie Gavard, J. Silvio Gutkind, 2006, Nature Cell Biology.

Regulation of G Protein-linked Guanine Nucleotide Exchange Factors for Rho, PDZ-RhoGEF, and LARG by Tyrosine Phosphorylation

J. Gutkind, S. Fukuhara, H. Chikumi, 2002, The Journal of Biological Chemistry.

MT1-MMP Controls Tumor-induced Angiogenesis through the Release of Semaphorin 4D*

J. Gutkind, J. Basile, T. Bugge, 2007, Journal of Biological Chemistry.

cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits

Susan S. Taylor, J. Gutkind, J. Vázquez-Prado, 2018, The Journal of Biological Chemistry.

Signaling from G Protein-coupled Receptors to ERK5/Big MAPK 1 Involves Gαq and Gα12/13 Families of Heterotrimeric G Proteins

J. Gutkind, S. Fukuhara, M. Marinissen, 2000, The Journal of Biological Chemistry.

The Rho Family GTPase Cdc42 Regulates the Activation of Ras/MAP Kinase by the Exchange Factor Ras-GRF*

D. Matallanas, P. Crespo, I. Arozarena, 2000, The Journal of Biological Chemistry.

A Novel PDZ Domain Containing Guanine Nucleotide Exchange Factor Links Heterotrimeric G Proteins to Rho*

J. Gutkind, S. Fukuhara, C. Murga, 1999, The Journal of Biological Chemistry.

LKB1/AMPK and PKA Control ABCB11 Trafficking and Polarization in Hepatocytes

J. Lippincott-Schwartz, P. Sengupta, J. Gutkind, 2014, PloS one.

WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Gα12/13

G. Schulte, E. Kostenis, J. Gutkind, 2016, Molecular Pharmacology.

Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases.

M. E. Lewis, K. Longenecker, Z. Derewenda, 2001, Structure.

Insulin-Like Growth Factor I Synergizes with Interleukin 4 for Hematopoietic Cell Proliferation Independent of Insulin Receptor Substrate Expression

L. Flechner, J. Gutkind, Weiqun Li, 1999, Molecular and Cellular Biology.

Potent Transforming Activity of the G13 α Subunit Defines a Novel Family of Oncogenes

T. Voyno-Yasenetskaya, J. Gutkind, N. Xu, 1994 .

Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation.

B. Nielsen, J. Gutkind, A. Molinolo, 2005, Genes & development.

Uncoupling of epidermal growth factor-dependent proliferation and invasion in a model of squamous carcinoma progression.

W. A. Yeudall, J. Ensley, J. Gutkind, 2005, Oral oncology.

G protein-regulated endocytic trafficking of adenylyl cyclase type 9

C. Dessauer, M. von Zastrow, J. Gutkind, 2020, bioRxiv.

Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure.

R. Pathmanathan, S. Cheong, R. Zain, 2009, Oral oncology.

Inhibition of basic leucine zipper transcription is a major mediator of atrial dilatation.

A. Aronheim, J. Gutkind, H. Miyazaki, 2006, Cardiovascular research.

Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells.

J. Gutkind, S. Hermouet, A. Spiegel, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Granulocyte Colony-stimulating Factor Induces Erk5 Activation, Which Is Differentially Regulated by Protein-tyrosine Kinases and Protein Kinase C

J. Gutkind, F. Dong, A. Larner, 2001, The Journal of Biological Chemistry.

Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12

Bryan Frank, N. Lee, N. Lee, 2005, Oncogene.

The p53 tumor suppressor targets a novel regulator of G protein signaling.

S. Velasco-Miguel, L. Buckbinder, R. Talbott, 1997, Proceedings of the National Academy of Sciences of the United States of America.

An NF-κB gene expression signature contributes to Kaposi's sarcoma virus vGPCR-induced direct and paracrine neoplasia

J. Gutkind, D. Martin, Y. Ji, 2008, Oncogene.

Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis

James B. Mitchell, D. Raben, P. Dijke, 2013, Nature Medicine.

Control of regulatory T cell and Th17 cell differentiation by inhibitory helix-loop-helix protein Id3

J. Vaqué, J. Gutkind, Y. Zhuang, 2010, Nature immunology.

Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma.

J. Gutkind, A. Molinolo, M. Lionakis, 2015, Cancer research.

CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis.

Amber N. Stratman, G. Davis, J. Gutkind, 2012, Blood.

Interactions of protein kinase CK2 subunits.

T. Blundell, N. Srinivasan, J. Gutkind, 1999 .

Persistent Activation of the Akt Pathway in Head and Neck Squamous Cell Carcinoma

E. Sausville, C. Conti, J. Gutkind, 2004, Clinical Cancer Research.

Complementary Roles of Intracellular and Pericellular Collagen Degradation Pathways In Vivo

J. Gutkind, N. Behrendt, T. Bugge, 2007, Molecular and Cellular Biology.

c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase

J. Gutkind, A. Molinolo, T. Bugge, 2010, Oncogene.

Novel insights into G protein and G protein-coupled receptor signaling in cancer.

J. Gutkind, M. O'Hayre, M. S. Degese, 2014, Current opinion in cell biology.

Exploiting the head and neck cancer oncogenome: widespread PI3K-mTOR pathway alterations and novel molecular targets.

J. Gutkind, R. Iglesias-Bartolome, Daniel Martin, 2013, Cancer discovery.

The PH domain of Ras-GAP is sufficient forin Vitro binding toβγ subunits of heterotrimeric G proteins

W. Simonds, J. Gutkind, D. Mahadevan, 1996, Cellular and Molecular Neurobiology.

The Small GTP-binding Protein Rho Activates c-Jun N-terminal Kinases/Stress-activated Protein Kinases in Human Kidney 293T Cells

P. Crespo, J. Gutkind, T. Igishi, 1996, The Journal of Biological Chemistry.

Signaling from G Protein-coupled Receptors to c-Jun Kinase Involves Subunits of Heterotrimeric G Proteins Acting on a Ras and Rac1-dependent Pathway (*)

W. Simonds, J. Gutkind, H. Teramoto, 1996, The Journal of Biological Chemistry.

Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ–focal adhesion kinase signaling circuitry

O. Harismendy, S. Lippman, P. Mali, 2022, The Journal of biological chemistry.

Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential

Sheng Li, J. Gutkind, J. Tesmer, 2019, Science Signaling.

The basic domain of HIV-tat transactivating protein is essential for its targeting to lipid rafts and regulating fibroblast growth factor-2 signaling in podocytes isolated from children with HIV-1-associated nephropathy.

J. Gutkind, J. Das, P. Ray, 2014, Journal of the American Society of Nephrology : JASN.

Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity.

J. Gutkind, R. Visconti, M. Chiariello, 2000, Blood.

The Mood Stabilizer Valproic Acid Activates Mitogen-activated Protein Kinases and Promotes Neurite Growth*

H. Manji, J. Gutkind, Guang Chen, 2001, The Journal of Biological Chemistry.

How mitogen-activated protein kinases recognize and phosphorylate their targets: A QM/MM study.

Gerhard Hummer, Adrian Gustavo Turjanski, G. Hummer, 2009, Journal of the American Chemical Society.

Interaction between FGFR-2, STAT5, and progesterone receptors in breast cancer.

J. Vaqué, J. Gutkind, S. Vanzulli, 2011, Cancer research.

Direct transmembrane clustering and cytoplasmic dimerization of focal adhesion kinase initiates its tyrosine phosphorylation.

Kenneth M. Yamada, C. Vinson, J. Gutkind, 2002, Biochimica et biophysica acta.

CKA, a Novel Multidomain Protein, Regulates the JUN N-Terminal Kinase Signal Transduction Pathway in Drosophila

N. Perrimon, J. Gutkind, M. Marinissen, 2002, Molecular and Cellular Biology.

Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential

J. Gutkind, Yi Zheng, A. Barac, 2004, Oncogene.

Structural and Biochemical Basis for Ubiquitin Ligase Recruitment by Arrestin-related Domain-containing Protein-3 (ARRDC3)*

Shiqian Qi, James H. Hurley, J. Hurley, 2013, The Journal of Biological Chemistry.

An interplay between the p38 MAPK pathway and AUBPs regulates c-fos mRNA stability during mitogenic stimulation.

J. Gutkind, M. S. Degese, D. Chiappe, 2015, The Biochemical journal.

Regulation of c-myc expression by PDGF through Rho GTPases

Maria Julia Marinissen, J. Gutkind, M. Marinissen, 2001, Nature Cell Biology.

Phosphorylation of the Carboxyl-Terminal Transactivation Domain of c-Fos by Extracellular Signal-Regulated Kinase Mediates the Transcriptional Activation of AP-1 and Cellular Transformation Induced by Platelet-Derived Growth Factor

J. Gutkind, M. Marinissen, P. Monje, 2003, Molecular and Cellular Biology.

Levels of sirolimus in saliva and blood following oral topical sustained-release varnish delivery system application

J. Gutkind, M. Friedman, R. Czerninski, 2015, Cancer Chemotherapy and Pharmacology.

The homozygous CX3CR1-M280 mutation impairs human monocyte survival.

J. Gutkind, M. O'Hayre, Melissa D. Johnson, 2018, JCI insight.

The homozygous CX 3 CR 1M 280 mutation impairs human monocyte survival

J. Gutkind, M. O'Hayre, Melissa D. Johnson, 2018 .

Matrix Metalloproteinase-activated Anthrax Lethal Toxin Demonstrates High Potency in Targeting Tumor Vasculature*

Alfredo Molinolo, Shihui Liu, S. Leppla, 2008, Journal of Biological Chemistry.

Cyclooxygenase-2 and colorectal cancer chemoprevention: the beta-catenin connection.

J. Gutkind, M. Castellone, H. Teramoto, 2006, Cancer research.

Levels of sirolimus in saliva and blood following mouthwash application.

J. Gutkind, M. Friedman, R. Czerninski, 2014, Oral diseases.

Tensin can induce JNK and p38 activation.

K. Matsumoto, K. Yamada, J. Gutkind, 2000, Biochemical and biophysical research communications.

Divergent Signaling Pathways Link Focal Adhesion Kinase to Mitogen-activated Protein Kinase Cascades

K. Yamada, J. Gutkind, S. Fukuhara, 1999, The Journal of Biological Chemistry.

THE KSHV/HHV 8 G PROTEIN COUPLED RECEPTOR IS A VIRAL ONCOGENE AND ANGIOGENESIS ACTIVATOR

E. Cesarman, J. Gutkind, M. Gershengorn, 1998 .

This is an open-access article distributed under the terms of the Creative Commons Public Domain declara...

Gerhard Hummer, Adrian Gustavo Turjanski, Robert B. Best, 2008 .

Biological function of PDGF-induced PI-3 kinase activity: its role in alpha PDGF receptor-mediated mitogenic signaling

D Mahadevan, J. Gutkind, J. Pierce, 1994, The Journal of cell biology.

mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family.

J. Gutkind, M. Marinissen, S. Hou, 2002, Genes & development.

PDZ-RhoGEF and LARG Are Essential for Embryonic Development and Provide a Link between Thrombin and LPA Receptors and Rho Activation*

H. Yagi, J. Gutkind, S. Fukuhara, 2013, The Journal of Biological Chemistry.

Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation

M. Barbacid, P. Crespo, J. Gutkind, 1997, Oncogene.

Prevention of Tumor Growth Driven by PIK3CA and HPV Oncogenes by Targeting mTOR Signaling with Metformin in Oral Squamous Carcinomas Expressing OCT3

V. Steele, A. Bode, I. Stijleman, 2015, Cancer Prevention Research.

Liver kinase B1 regulates hepatocellular tight junction distribution and function in vivo

C. V. Van Itallie, James M. Anderson, J. Gutkind, 2016, Hepatology.

Regulation of the Transcriptional Activity of c-Fos by ERK

J. Gutkind, M. Castellone, J. Hernández-Losa, 2005, Journal of Biological Chemistry.

Impairing squamous differentiation by Klf4 deletion is sufficient to initiate tongue carcinoma development upon K-Ras activation in mice.

J. Gutkind, E. D. Bal de Kier Joffé, M. Paparella, 2014, Carcinogenesis.

Protein Kinase C-related Kinase and ROCK Are Required for Thrombin-induced Endothelial Cell Permeability Downstream from Gα12/13 and Gα11/q*

J. Gutkind, J. Gavard, 2008, Journal of Biological Chemistry.

Proteome-wide analysis of head and neck squamous cell carcinomas using laser-capture microdissection and tandem mass spectrometry.

W. Hancock, J. Myers, J. Ensley, 2005, Oral oncology.

Rac inhibits thrombin-induced Rho activation: evidence of a Pak-dependent GTPase crosstalk

J. Gutkind, M. Castellone, H. Rosenfeldt, 2006, Journal of molecular signaling.

Investigation of the catalytic mechanism of farnesyl pyrophosphate synthase by computer simulation.

A. Turjanski, A. Crespo, J. Gutkind, 2006, The journal of physical chemistry. B.

Gene expression changes in a patient presenting nonleukaemic nasal granulocytic sarcoma to acute myelogenous leukaemia using 40 K cDNA microarray.

N. Lee, M. Shikami, J. Gutkind, 2006, Clinical and laboratory haematology.

Robo4 Signaling in Endothelial Cells Implies Attraction Guidance Mechanisms*

J. Gutkind, M. Castellone, V. Bedell, 2006, Journal of Biological Chemistry.

Chimeric Gαi2/Gα13 Proteins Reveal the Structural Requirements for the Binding and Activation of the RGS-like (RGL)-containing Rho Guanine Nucleotide Exchange Factors (GEFs) by Gα13*

J. Gutkind, M. Castellone, H. Miyazaki, 2004, Journal of Biological Chemistry.

Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons.

Vyomesh Patel, Philip Grant, M. Strong, 2007, Molecular biology of the cell.

Dissecting the Akt/Mammalian Target of Rapamycin Signaling Network: Emerging Results from the Head and Neck Cancer Tissue Array Initiative

D. Wong, S. Hewitt, D. Saranath, 2007, Clinical Cancer Research.

Integrin αβ1, αvβ, α6β effectors p130Cas, Src and talin regulate carcinoma invasion and chemoresistance.

J. Yates, J. Gutkind, V. Patel, 2011, Biochemical and biophysical research communications.

M. Brann, J. Gutkind, E. Currier, 1998, Oncogene.

EPS8 upregulates FOXM1 expression, enhancing cell growth and motility.

W. A. Yeudall, J. Gutkind, V. Patel, 2010, Carcinogenesis.

Brag2 differentially regulates β1- and β3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis

E. Chavakis, A. Zeiher, S. Dimmeler, 2014, Basic Research in Cardiology.

Novel Molecular Mediators in the Pathway Connecting G-protein-coupled Receptors to MAP Kinase Cascades

J. Gutkind, S. Fukuhara, C. Murga, 1999, Trends in Endocrinology & Metabolism.

The Gα12/13 Family of Heterotrimeric G Proteins and the Small GTPase RhoA Link the Kaposi Sarcoma-associated Herpes Virus G Protein-coupled Receptor to Heme Oxygenase-1 Expression and Tumorigenesis*

M. J. Martín, J. Gutkind, M. Marinissen, 2007, Journal of Biological Chemistry.

Galpha12 requires acylation for its transforming activity.

J. Gutkind, T. L. Jones, 1998, Biochemistry.

p35/Cyclin-Dependent Kinase 5 Phosphorylation of Ras Guanine Nucleotide Releasing Factor 2 (RasGRF2) Mediates Rac-Dependent Extracellular Signal-Regulated Kinase 1/2 Activity, Altering RasGRF2 and Microtubule-Associated Protein 1b Distribution in Neurons

A. Kulkarni, J. Gutkind, R. Nijhara, 2004, The Journal of Neuroscience.

Expression of heme oxygenase-1 in non-small cell lung cancer (NSCLC) and its correlation with clinical data.

S. Hewitt, J. Gutkind, M. M. Facchinetti, 2012, Lung cancer.

Gene discovery in oral squamous cell carcinoma through the Head and Neck Cancer Genome Anatomy Project: confirmation by microarray analysis.

R. Strausberg, J. Gillespie, M. Emmert-Buck, 2003, Oral oncology.

Receptor Tyrosine Kinases Activate Canonical WNT/ b Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct b -Catenin Phosphorylation

E. Jabs, A. Kozubík, W. Wilcox, 2012 .

Potent transforming activity of the G13 alpha subunit defines a novel family of oncogenes.

T. Voyno-Yasenetskaya, J. Gutkind, N. Xu, 1994, Biochemical and biophysical research communications.

Semaphorin 4D/Plexin-B1 Induces Endothelial Cell Migration through the Activation of PYK2, Src, and the Phosphatidylinositol 3-Kinase-Akt Pathway

K. Guan, J. Gutkind, J. Basile, 2005, Molecular and Cellular Biology.

Semaphorin 4 D / Plexin-B 1 Induces Endothelial Cell Migration through the Activation of PYK 2 , Src , and the Phosphatidylinositol 3-Kinase – Akt Pathway

J. Gutkind, J. Basile, Talayeh Afkhami, 2005 .

Tyrosine kinases of the Src family participate in signaling to MAP kinase from both Gq and Gi-coupled receptors.

J. Gutkind, T. Igishi, 1998, Biochemical and biophysical research communications.

Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis.

Amber N. Stratman, J. Gutkind, R. Adams, 2016, Developmental biology.

Cryo–electron microscopy structure and analysis of the P-Rex1–Gβγ signaling scaffold

Michael A. Cianfrocco, Sheng Li, Jennifer N. Cash, 2019, Science Advances.

The Constitutively Active Mutant Gα13Transforms Mouse Fibroblast Cells Deficient in Insulin-like Growth Factor-I Receptor*

D. Leroith, J. Gutkind, V. Blakesley, 1997, The Journal of Biological Chemistry.

The PH domain of Ras-GAP is sufficient for in vitro binding to beta gamma subunits of heterotrimeric G proteins.

W. Simonds, J. Gutkind, D. Mahadevan, 1996, Cellular and molecular neurobiology.

PI3K pathway is involved in ERK signaling cascade activation by histamine H2R agonist in HEK293T cells.

J. Gutkind, C. Shayo, C. Davio, 2016, Biochimica et biophysica acta.

Agonist-induced Ca2+ Sensitization in Smooth Muscle

Z. Derewenda, J. Gutkind, D. Trentham, 2013, The Journal of Biological Chemistry.

Genome-wide analysis of oral cancer--early results from the Cancer Genome Anatomy Project.

R. Strausberg, J. Ensley, J. Gutkind, 2000, Oral oncology.

Fluorescent, bioactive protein nanoparticles (prodots) for rapid, improved cellular uptake.

J. Gutkind, C. Kumar, V. Patel, 2015, Bioconjugate chemistry.

Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer

J. Gutkind, A. Sakurai, C. Doçi, 2012, Cell Research.

Modular architecture and novel protein-protein interactions regulating the RGS-containing Rho guanine nucleotide exchange factors.

J. Gutkind, J. Basile, J. Vázquez-Prado, 2004, Methods in enzymology.

P‐REX2, a novel PI‐3‐kinase sensitive Rac exchange factor

J. Gutkind, H. Rosenfeldt, J. Vázquez-Prado, 2004, FEBS letters.

Angiotensin II and Basic Fibroblast Growth Factor Mitogenic Pathways in Human Fetal Mesangial Cells

J. Gutkind, E. Izevbigie, P. Ray, 2000, Pediatric Research.

Gene expression profiles in squamous cell carcinomas of the oral cavity: use of laser capture microdissection for the construction and analysis of stage-specific cDNA libraries.

J. Gillespie, M. Emmert-Buck, D. Krizman, 2000, Oral oncology.

Gαs directly drives PDZ-RhoGEF signaling to Cdc42

J. Gutkind, J. Vázquez-Prado, I. García-Jiménez, 2020, The Journal of Biological Chemistry.

Keeping the epidermal stem cell niche in shape.

J. Gutkind, R. Iglesias-Bartolome, 2010, Cell stem cell.

Therapeutics , Targets , and Chemical Biology p 21-Activated Kinase 1 Is Required for Ef fi cient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model

Ich, A. Jubb, J. Gutkind, 2012 .

Dual Effect of b-Adrenergic Receptors on Mitogen-activated Protein Kinase

P. Crespo, T. Cachero, J. Gutkind, 1995 .

Signaling from G protein-coupled receptors to c-Jun kinase involves beta gamma subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway.

W. Simonds, J. Gutkind, H. Teramoto, 1996, The Journal of biological chemistry.

Role of the cAMP and MAPK pathways in the transformation of mouse 3T3 fibroblasts by a TSHR gene constitutively activated by point mutation

P. Crespo, S. Filetti, D. Russo, 2000, Oncogene.

1 Interaction between FGFR-2 , STAT 5 and progesterone receptors in breast cancer

J. Vaqué, J. Gutkind, S. Vanzulli, 2011 .

Novel 1-phenylcycloalkanecarboxylic acid derivatives are potent and selective sigma 1 ligands.

J. Gutkind, A. Newman, T. Su, 1994, Journal of medicinal chemistry.

Phosphoinositide-3-Kinase Mediated Activation of JNK by the ßPDGFR

J. Gutkind, M. Heidaran, M. Lopez-Ilasaca, 1997 .

IGF-1/IGF-1R/FAK/YAP Transduction Signaling Prompts Growth Effects in Triple-Negative Breast Cancer (TNBC) Cells

J. Gutkind, J. S. Gutkind, F. Cirillo, 2020, Cells.

Assembly and activation of the Hippo signalome by FAT1 tumor suppressor

P. Tamayo, S. Lippman, Y. Samuels, 2018, Nature Communications.

Probes for narcotic receptor mediated phenomena 22. (1) synthesis and characterization of optically pure [3H](+)-4-[(αR)-α-((2S, 5R)-4-propyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N, N-diethylbenzamide, [3H]SNC 121, a novel high affinity and select

J. Gutkind, K. Rice, R. Rothman, 1996 .

Onco-GPCR signaling and dysregulated expression of microRNAs in human cancer

J. Gutkind, J. S. Gutkind, N. Nohata, 2016, Journal of Human Genetics.

Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery.

James F Rusling, J Silvio Gutkind, Vyomesh Patel, 2009, ACS nano.

Cyclooxygenase-2 and Colorectal Cancer Chemoprevention: The B -Catenin Connection

J. Gutkind, M. Castellone, H. Teramoto, 2006 .

Assembly and activation of the Hippo signalome by FAT1 tumor suppressor

P. Tamayo, S. Lippman, Y. Samuels, 2018, Nature Communications.

Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK

R. Sunahara, M. von Zastrow, J. Gutkind, 2017, Science Signaling.

Granulocyte Colony-stimulating Factor Induces Erk5 Activation, Which Is Differentially Regulated by Protein-tyrosine Kinases and Protein Kinase C REGULATION OF CELL PROLIFERATION AND SURVIVAL*

J. Gutkind, F. Dong, A. Larner, 2001 .

SET protein accumulates in HNSCC and contributes to cell survival: antioxidant defense, Akt phosphorylation and AVOs acidification.

E. Tajara, J. Gutkind, C. Pestana, 2012, Oral oncology.

Binding-Induced Folding of a Natively Unstructured Transcription Factor

G. Hummer, R. Best, A. Turjanski, 2008, PLoS Comput. Biol..

Protein Kinase C-related Kinase and ROCK Are Required for Thrombin-induced Endothelial Cell Permeability Downstream from Gα12/13 and Gα11/q*

J. Gutkind, J. Gavard, 2008, Journal of Biological Chemistry.

Interleukin-21 expression and its association with proinflammatory cytokines in untreated chronic periodontitis patients.

J. Vaqué, J. Gutkind, L. Abusleme, 2012, Journal of periodontology.

Regulation of Mitogen-Activated Protein Kinase Signaling Networks by G Protein-Coupled Receptors

J. Gutkind, 2000, Science's STKE.

A phase I study of everolimus in combination with cetuximab and cisplatin as first-line therapy in recurrent and metastatic (R/M) head and neck squamous cell carcinoma (HNSCC).

C. Chung, J. Gutkind, A. Molinolo, 2012 .

Molecular mechanisms deployed by virally encoded G protein-coupled receptors in human diseases.

R. Abagyan, I. Kufareva, J. Gutkind, 2013, Annual review of pharmacology and toxicology.

PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets

R. Nussenblatt, Yihai Cao, J. Gutkind, 2010, Proceedings of the National Academy of Sciences.

Signals and Receptors.

C. Heldin, J. Gutkind, Benson Lu, 2016, Cold Spring Harbor perspectives in biology.

1 Therapeutics, Targets, and Chemical Biology

A. Jubb, K. Hoeflich, J. Gutkind, 2012 .

PDZ-RhoGEF and LARG Are Essential for Embryonic Development and Provide a Link between Thrombin and LPA Receptors and Rho Activation*

H. Yagi, J. Gutkind, S. Fukuhara, 2013, The Journal of Biological Chemistry.

G a s directly drives PDZ-RhoGEF signaling to Cdc42

J. Gutkind, J. Vázquez-Prado, I. García-Jiménez, 2020 .