A. Lin

发表

Novel strategies for inhibition of the p38 MAPK pathway.

B. Shen, Jiyan Zhang, A. Lin, 2007, Trends in pharmacological sciences.

Integration of Apoptosis Signal-Regulating Kinase 1-Mediated Stress Signaling with the Akt/Protein Kinase B-IκB Kinase Cascade

F. Khuri, H. Fu, A. Lin, 2013, Molecular and Cellular Biology.

The BH3-only protein BAD mediates TNFα cytotoxicity despite concurrent activation of IKK and NF-κB in septic shock

H. Zhang, A. Lin, Beicheng Sun, 2018, Cell Research.

Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK.

G L Johnson, M. Karin, M. McMahon, 1994, Science.

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

M. Karin, A. Abo, A. Lin, 1995, Cell.

NF-κB at the crossroads of life and death

Michael Karin, M. Karin, A. Lin, 2002, Nature Immunology.

Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-α–induced JNK activation and inflammation

Yingming Zhao, A. Lin, Jie Yan, 2011, Proceedings of the National Academy of Sciences.

Temporal control of TNFα signaling by Miz1.

A. Lin, 2011, Advances in experimental medicine and biology.

Inhibition of JNK activation through NF-kappaB target genes.

M. Karin, Y. Minemoto, A. Lin, 2001, Nature.

Protein phosphatase 2A potentiates activity of promoters containing AP-1-binding elements

M. Karin, A. Schönthal, M. Mumby, 1993, Molecular and cellular biology.

Signaling intermediates required for NF-kappa B activation and IL-8 expression in CF bronchial epithelial cells.

A. Lin, M. Hershenson, Jing Li, 2003, American journal of physiology. Lung cellular and molecular physiology.

Protein kinase A determines platelet life span and survival by regulating apoptosis

A. Lin, Chunyan He, C. Ruan, 2017, The Journal of clinical investigation.

Activation of nuclear factor- B is necessary for myotrophin-induced cardiac hypertrophy

A. Lin, N. Purcell, Sudhiranjan Gupta, 2002 .

Blocking Caspase-3-Mediated Proteolysis of IKKβ Suppresses TNF-α-Induced Apoptosis

Y. Minemoto, A. Lin, G. Tang, 2001 .

The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop.

J. Sznajder, Danica Chen, A. Agustí, 2017, The journals of gerontology. Series A, Biological sciences and medical sciences.

Regulation of Airway Epithelial Cell NF-κB-Dependent Gene Expression by Protein Kinase Cδ1

I. Weinstein, A. Brasier, A. Lin, 2003, The Journal of Immunology.

BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages

Weiguo Zou, A. Lin, J. Xiang, 2020, eLife.

The JNKK2-JNK1 Fusion Protein Acts As a Constitutively Active c-Jun Kinase That Stimulates c-Jun Transcription Activity*

T. Hunter, A. Lin, Chaojun Zheng, 1999, The Journal of Biological Chemistry.

Bacterial effector NleL promotes enterohemorrhagic E. coli-induced attaching and effacing lesions by ubiquitylating and inactivating JNK

G. Gao, L. Hui, Jinghua Yan, 2017, PLoS pathogens.

Cytosolic PLA2 is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15

M. Tretiakova, E. Ebert, A. Lin, 2009, The Journal of experimental medicine.

Coordinate Regulation of IκB Kinases by Mitogen-Activated Protein Kinase Kinase Kinase 1 and NF-κB-Inducing Kinase

A. Lin, S. Nemoto, J. DiDonato, 1998, Molecular and Cellular Biology.

Selective Inactivation of c-Jun NH2-Terminal Kinase in Adipose Tissue Protects Against Diet-Induced Obesity and Improves Insulin Sensitivity in Both Liver and Skeletal Muscle in Mice

A. Lin, A. Xu, G. Sweeney, 2011, Diabetes.

Ubl4A is required for insulin-induced Akt plasma membrane translocation through promotion of Arp2/3-dependent actin branching

Dianqing Wu, A. Lin, Yuzhu Zhang, 2015, Proceedings of the National Academy of Sciences.

Erratum: Regulation of airway epithelial cell NF-κB-dependent gene expression by protein kinase Cδ (Journal of Immunology (2003) 170 (5681-5689))

I. Weinstein, A. Brasier, A. Lin, 2003 .

Ras and mitogen-activated protein kinase kinase kinase-1 coregulate activator protein-1- and nuclear factor-kappaB-mediated gene expression in airway epithelial cells.

A. Lin, M. Hershenson, Jing Li, 2003, American journal of respiratory cell and molecular biology.

IKK antagonizes CD95 ligation-mediated apoptosis by regulating NF-κB activity

Jing Wang, Yan Li, B. Shen, 2007 .

Activation of NF-κB by hepatitis B virus X protein through an IκB kinase-independent mechanism

N. Paran, Y. Shaul, S. Yamaoka, 2001 .

Activation of nuclear factor- (cid:2) B is necessary for myotrophin-induced cardiac hypertrophy

A. Lin, N. Purcell, Sudhiranjan Gupta, 2002 .

Activation of the JNK pathway is important for cardiomyocyte death in response to simulated ischemia

R. Gottlieb, A. Lin, Hai-ling Li, 1999, Cell Death and Differentiation.

TNF-α-Induced Apoptosis of Macrophages Following Inhibition of NF-κB: A Central Role for Disruption of Mitochondria1

H. Perlman, A. Lin, L. Pagliari, 2004, The Journal of Immunology.

B-Dependent Gene Expression by Protein k Regulation of Airway Epithelial Cell NF-R.

I. Weinstein, A. Lin, J. Soh, 2003 .

Kinase C B-Dependent Gene Expression by Protein κ Regulation of Airway Epithelial Cell

I. Weinstein, A. Lin, J. Soh, 2003 .

PKCδ signaling: A dual role in regulating hypoxic stress-induced autophagy and apoptosis

D. Ann, A. Lin, J. Ou, 2009 .

TNF-alpha-induced apoptosis of macrophages following inhibition of NF-kappa B: a central role for disruption of mitochondria.

H. Perlman, A. Lin, L. Pagliari, 2004, Journal of immunology.

Toll-like receptor 6 drives differentiation of tolerogenic dendritic cells and contributes to LcrV-mediated plague pathogenesis.

A. Lin, O. Schneewind, Inyoung Kim, 2008, Cell host & microbe.

Blocking caspase-3-mediated proteolysis of IKKbeta suppresses TNF-alpha-induced apoptosis.

Y. Minemoto, A. Lin, J. Yang, 2001, Molecular cell.

Regulation of epidermal differentiation through KDF1‐mediated deubiquitination of IKKα

S. Weatherbee, A. Lin, J. Yue, 2020, EMBO reports.

Cyclic AMP Inhibits p38 Activation via CREB-Induced Dynein Light Chain

Jiyan Zhang, A. Lin, J. Xiang, 2006, Molecular and Cellular Biology.

Structure-Function Studies of p38 Mitogen-activated Protein Kinase

Jiahuai Han, E. Schwarz, A. Lin, 1997, The Journal of Biological Chemistry.

Akt-mediated platelet apoptosis and its therapeutic implications in immune thrombocytopenia

A. Lin, C. Ruan, R. Yan, 2018, Proceedings of the National Academy of Sciences.

Activation of NF-kB is required for hypertrophic growth of primary rat neonatal ventricular

A. Lin, F. Mercurio, J. DiDonato, 2001 .

Involvement of c‐Jun N‐terminal kinase in amyloid precursor protein‐mediated neuronal cell death

I. Nishimoto, A. Lin, Osahiko Tsuji, 2003, Journal of neurochemistry.

Control of AP-1 activity by signal transduction cascades.

M. Karin, A. Lin, J. Chambard, 1993, Advances in second messenger and phosphoprotein research.

Role of 14-3-3gamma in FE65-dependent gene transactivation mediated by the amyloid beta-protein precursor cytoplasmic fragment.

Toshiharu Suzuki, A. Lin, M. Miura, 2005, The Journal of biological chemistry.

NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta.

Dan Yang, Y. Minemoto, A. Lin, 2006, Molecular cell.

BAD Ser128 is not phosphorylated by c-Jun NH2-terminal kinase for promoting apoptosis.

Jiyan Zhang, A. Lin, Jing Liu, 2005, Cancer research.

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

M. Karin, A. Lin, M. Hibi, 1993, Genes & development.

kinases.subgroup of mitogen-activated protein the with activation of the JNK subgroup but not c-Jun N-terminal phosphorylation correlates

M. Cobb, A. Lin, A. Minden, 2013 .

ATIA: a link between inflammation and hypoxia.

A. Lin, 2011, Molecular cell.

A five-year itch in TNF-α cytotoxicity : The time factor determines JNK action

A. Lin, 2006 .

Integration of TNF-a Signaling: Crosstalk between IKK, JNK, and Caspases

A. Lin, 2003 .

Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2.

M. Karin, A. Lin, A. Minden, 1995, Science.

Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells.

A. Lin, T. Yoon, Jingpu Zhang, 2011, The international journal of biochemistry & cell biology.

Inhibition of JNK activation through NF-κB target genes

M. Karin, Y. Minemoto, A. Lin, 2001, Nature.

NF-kappaB at the crossroads of life and death.

Michael Karin, M. Karin, A. Lin, 2002, Nature immunology.

Hydrogen Peroxide Promotes Aβ Production through JNK-dependent Activation of γ-Secretase*S⃞

Chengyong Shen, A. Lin, Kejing Zhang, 2008, Journal of Biological Chemistry.

The tumor promoter arsenite stimulates AP‐1 activity by inhibiting a JNK phosphatase.

Wilfred W. Li, M. Karin, B. Su, 1996, The EMBO journal.

Novel Roles for Protein Kinase Cδ-dependent Signaling Pathways in Acute Hypoxic Stress-induced Autophagy*

H. Forman, D. Ann, A. Lin, 2008, Journal of Biological Chemistry.

Multi-Omics Analysis in β-Thalassemia Using an HBB Gene-Knockout Human Erythroid Progenitor Cell Model

Zhanghua Wu, A. Lin, Hongyan Chen, 2022, International journal of molecular sciences.

Constitutively Active Mitogen-activated Protein Kinase Kinase 6 (MKK6) or Salicylate Induces Spontaneous 3T3-L1 Adipogenesis*

J. Engelman, M. Lisanti, A. Lin, 1999, The Journal of Biological Chemistry.

Tumor Necrosis Factor-induced Long Myosin Light Chain Kinase Transcription Is Regulated by Differentiation-dependent Signaling Events

Jason X. Cheng, A. Lin, W. V. Graham, 2006, Journal of Biological Chemistry.

The Absence of NF-κB-Mediated Inhibition of c-Jun N-Terminal Kinase Activation Contributes to Tumor Necrosis Factor Alpha-Induced Apoptosis

A. Lin, Qing Dai, J. Xiang, 2002, Molecular and Cellular Biology.

Role of JNK activation in apoptosis: A double-edged sword

A. Lin, Jing Liu, 2005, Cell Research.

JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD.

Jing Liu, Jialing Xiang, Jiyan Zhang, 2004, Molecular cell.

Rewiring the Intracellular Signaling Network in Cancer

A. Lin, Jing Liu, 2012 .

Wiring the cell signaling circuitry by the NF-κB and JNK1 crosstalk and its applications in human diseases

A. Lin, J. Liu, Jing Liu, 2007, Oncogene.

NF-κB Is Required for UV-Induced JNK Activation via Induction of PKCδ

Dan Yang, Y. Minemoto, A. Lin, 2006 .

Activation of NF-κB is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes

A. Lin, F. Mercurio, N. Purcell, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Suppression of inflammation and acute lung injury by the transcription factor Miz1 via repression of C/EBP-δ

J. Sznajder, G. Mutlu, Liang Zhou, 2013, Nature Immunology.

Androgen via p21 Inhibits Tumor Necrosis Factor α-induced JNK Activation and Apoptosis*

A. Lin, J. Xiang, S. Liao, 2009, The Journal of Biological Chemistry.

MAPK pathways mediate hyperoxia-induced oncotic cell death in lung epithelial cells.

M. Birrer, A. Lin, E. Miller, 2003, Free radical biology & medicine.

Activation of the JNK signaling pathway: Breaking the brake on apoptosis

A. Lin, 2003, BioEssays : news and reviews in molecular, cellular and developmental biology.

12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced c-Jun N-terminal Kinase (JNK) Phosphatase Renders Immortalized or Transformed Epithelial Cells Refractory to TPA-inducible JNK Activity*

N. Park, A. Lin, Zhennan Gu, 2000, The Journal of Biological Chemistry.

Opposing Effects of Jun Kinase and p38 Mitogen-Activated Protein Kinases on Cardiomyocyte Hypertrophy

A. Lin, S. Nemoto, Z. Sheng, 1998, Molecular and Cellular Biology.

Identification of c-Jun NH2-terminal Protein Kinase (JNK)-activating Kinase 2 as an Activator of JNK but Not p38*

A. Lin, S. Nemoto, Xianghuai Lu, 1997, The Journal of Biological Chemistry.

c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases

M. Karin, M. Cobb, R. Davis, 1994, Molecular and cellular biology.

Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity

D. Brenner, J. Frost, T. Hunter, 1992, Cell.

Suppression of metastatic colonization by the context-dependent activation of the c-Jun NH2-terminal kinase kinases JNKK1/MKK4 and MKK7.

A. Lin, W. Stadler, C. Rinker-Schaeffer, 2005, Cancer research.

The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma.

D. Huo, A. Lin, C. Rinker-Schaeffer, 2006, Cancer research.

Caveolin‐mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo

J. Engelman, H. Jo, M. Lisanti, 1998, FEBS letters.

Activation of c‐Jun NH2‐terminal kinase is required for gemcitabine's cytotoxic effect in human lung cancer H1299 cells

Wei Guo, A. Lin, B. Fang, 2005, FEBS letters.

BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology

A. Lin, Beicheng Sun, J. Xiang, 2021, iScience.

Phosphorylation of Bad at Thr-201 by JNK1 Promotes Glycolysis through Activation of Phosphofructokinase-1*

Yingming Zhao, Jianqun Chen, A. Lin, 2008, Journal of Biological Chemistry.

Induction of Apoptosis by SB202190 through Inhibition of p38β Mitogen-activated Protein Kinase*

Shuang Huang, A. Lin, S. Nemoto, 1998, Journal of Biological Chemistry.

Inactivation of BAD by IKK Inhibits TNFα-Induced Apoptosis Independently of NF-κB Activation

Jiyan Zhang, N. Danial, A. Lin, 2013, Cell.

Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1

F. Guillemot, Nengyin Sheng, Zhihui Xie, 2010, Proceedings of the National Academy of Sciences.

Androgen and Its Receptor Promote Bax-Mediated Apoptosis

A. Lin, J. Xiang, B. Godfrey, 2006, Molecular and Cellular Biology.

SIP30 Is Regulated by ERK in Peripheral Nerve Injury-induced Neuropathic Pain*

A. Lin, Guangdun Peng, N. Jing, 2009, The Journal of Biological Chemistry.

NF-κB in cancer: a marked target

Michael Karin, M. Karin, A. Lin, 2003 .

Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-α-induced JNK1 activation

Yingming Zhao, M. Eilers, A. Lin, 2009, Proceedings of the National Academy of Sciences.

Cyclic AMP inhibits JNK activation by CREB-mediated induction of c-FLIPL and MKP-1, thereby antagonizing UV-induced apoptosis

A. Lin, J. Xiang, J. Zhang, 2008, Cell Death and Differentiation.

c-Jun N-Terminal Protein Kinase 1 (JNK1), but Not JNK2, Is Essential for Tumor Necrosis Factor Alpha-Induced c-Jun Kinase Activation and Apoptosis

Y. Minemoto, A. Lin, Jing Liu, 2004, Molecular and Cellular Biology.

The true face of JNK activation in apoptosis

A. Lin, B. Dibling, 2002, Aging cell.

NF-kappaB in cancer: a marked target.

Michael Karin, M. Karin, A. Lin, 2003, Seminars in cancer biology.

The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation.

Guisheng Zhong, A. Lin, Beicheng Sun, 2021, Immunity.

The p 38 Kinases MKK 4 and MKK 6 Suppress Metastatic Colonization in Human Ovarian Carcinoma

D. Huo, A. Lin, C. Rinker-Schaeffer, 2006 .

c-Jun Amino-Terminal Kinase-1 Mediates Glucose-Responsive Upregulation of the RNA Editing Enzyme ADAR2 in Pancreatic Beta-Cells

A. Lin, Ping Huang, Feng Li, 2012, PloS one.

The BH3-only protein BAD mediates TNFα cytotoxicity despite concurrent activation of IKK and NF-κB in septic shock

H. Zhang, A. Lin, Beicheng Sun, 2018, Cell Research.

Role of 14-3-3γ in FE65-dependent Gene Transactivation Mediated by the Amyloid β-Protein Precursor Cytoplasmic Fragment*

Toshiharu Suzuki, A. Lin, M. Miura, 2005, Journal of Biological Chemistry.

PKC delta signaling: a dual role in regulating hypoxic stress-induced autophagy and apoptosis.

D. Ann, A. Lin, J. Ou, 2009, Autophagy.

Regulation of airway epithelial cell NF-kappa B-dependent gene expression by protein kinase C delta.

I. Weinstein, A. Brasier, A. Lin, 2003, Journal of immunology.

Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity.

J. Frost, T. Hunter, M. Karin, 1992, Cell.

Dynamic Positive Feedback Phosphorylation of Mixed Lineage Kinase 3 by JNK Reversibly Regulates Its Distribution to Triton-soluble Domains*

A. Lin, K. Gallo, Karen A Schachter, 2006, Journal of Biological Chemistry.

Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers.

Ximing J. Yang, M. Rubin, A. Lin, 2001, Cancer research.

The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop.

Danica Chen, A. Agustí, R. Morimoto, 2017, The journals of gerontology. Series A, Biological sciences and medical sciences.

The JNK Signaling Pathway

A. Lin, 2006 .