P. Heeringa

M. van Meurs, H. Hammes, M. Struys, 2013, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Beneficial Effects of an Alternating High- Fat Dietary Regimen on Systemic Insulin Resistance, Hepatic and Renal Inflammation and Renal Function

T. Kooistra, R. Kleemann, G. Molema, 2012, PloS one.

TNF-alpha bioactivity-inhibiting therapy in ANCA-associated vasculitis: clinical and experimental considerations.

P. Heeringa, J. Tervaert, D. Huugen, 2006, Clinical journal of the American Society of Nephrology : CJASN.

Peripheral blood myeloperoxidase activity increases during hemodialysis.

P. Heeringa, F. M. van der Sande, J. Kooman, 2003, Kidney international.

High mobility group box 1 skews macrophage polarization and negatively influences phagocytosis of apoptotic cells.

P. Limburg, M. Bijl, J. Westra, 2016, Rheumatology.

Coexpression of CD177 and membrane proteinase 3 on neutrophils in antineutrophil cytoplasmic autoantibody-associated systemic vasculitis: anti-proteinase 3-mediated neutrophil activation is independent of the role of CD177-expressing neutrophils.

C. Kallenberg, P. Limburg, M. Bijl, 2009, Arthritis and rheumatism.

University of Groningen Identification of novel genes associated with renal tertiary lymphoid organ formation in aging

R. Korstanje, P. Heeringa, J. Hillebrands, 2014 .

Novel PET Imaging of Inflammatory Targets and Cells for the Diagnosis and Monitoring of Giant Cell Arteritis and Polymyalgia Rheumatica

P. Nienhuis, P. Heeringa, R. Slart, 2022, Frontiers in Medicine.

Relationship between myeloperoxidase promotor polymorphism and disease severity in sarcoidosis.

J. de Vries, P. Heeringa, J. C. Cohen Tervaert, 2003, European journal of internal medicine.

Chapter 8 Relationship of myeloperoxidase promotor polymorphism and disease severity in sarcoidosis ?

J. Vries, P. Heeringa, M. Drent, 2008 .

Functionally Heterogenous Macrophage Subsets in the Pathogenesis of Giant Cell Arteritis: Novel Targets for Disease Monitoring and Treatment

P. Heeringa, A. Boots, E. Brouwer, 2021, Journal of clinical medicine.

Renal expression of endothelial and inducible nitric oxide synthase, and formation of peroxynitrite‐modified proteins and reactive oxygen species in Wegener's granulomatosis

C. Kallenberg, M. Bijl, P. Heeringa, 2001, The Journal of pathology.

What Is the Current Evidence for Disease Subsets in Giant Cell Arteritis?

P. Heeringa, W. Abdulahad, N. Bos, 2018 .

Plasma Pyruvate Kinase M2 as a marker of vascular inflammation in giant cell arteritis

P. Nienhuis, P. Heeringa, R. Slart, 2021, Rheumatology.

Hemorrhagic Shock-induced Endothelial Cell Activation in a Spontaneous Breathing and a Mechanical Ventilation Hemorrhagic Shock Model Is Induced by a Proinflammatory Response and Not by Hypoxia

M. van Meurs, G. Molema, J. Zijlstra, 2011, Anesthesiology.

Complement system activation in ANCA vasculitis: A translational success story?

C. Kallenberg, P. Heeringa, 2015, Molecular immunology.

The role of neutrophils in the induction of glomerulonephritis by anti-myeloperoxidase antibodies.

P. Heeringa, N. Maeda, R. Falk, 2005, The American journal of pathology.

Complement Activation Is Involved in Renal Damage in Human Antineutrophil Cytoplasmic Autoantibody Associated Pauci-Immune Vasculitis

Min Chen, C. Kallenberg, P. Heeringa, 2009, Journal of Clinical Immunology.

Effect of age and sex on immune checkpoint expression and kinetics in human T cells

P. Heeringa, A. Boots, E. Brouwer, 2020, Immunity & Ageing.

Ageing enhances cellular immunity to myeloperoxidase and experimental anti-myeloperoxidase glomerulonephritis.

P. Heeringa, S. Holdsworth, E. Brouwer, 2021, Rheumatology.

Protective effect of rosiglitazone on kidney function in high-fat challenged human-CRP transgenic mice: a possible role for adiponectin and miR-21?

T. Kooistra, R. Kleemann, P. Heeringa, 2017, Scientific Reports.

Towards precision medicine in ANCA-associated vasculitis.

C. Kallenberg, P. Heeringa, A. Boots, 2018, Rheumatology.

Pathogenesis of ANCA-associated vasculitis: new possibilities for intervention.

C. Kallenberg, P. Heeringa, W. Abdulahad, 2013, American journal of kidney diseases : the official journal of the National Kidney Foundation.

University of Groningen Low anti-staphylococcal IgG responses in granulomatosis with polyangiitis patients despite long-term Staphylococcus aureus exposure Glasner,

Jan Maarten van Dijl, C. Kallenberg, P. Heeringa, 2015 .

Mycophenolic acid and 6-mercaptopurine both inhibit B-cell proliferation in granulomatosis with polyangiitis patients, whereas only mycophenolic acid inhibits B-cell IL-6 production

P. Heeringa, A. von Borstel, W. Abdulahad, 2020, PloS one.

Circulating CD24hiCD38hi regulatory B cells correlate inversely with the ThEM17 cell frequency in granulomatosis with polyangiitis patients.

P. Heeringa, A. von Borstel, W. Abdulahad, 2019, Rheumatology.

Kv1.3 blockade by ShK186 modulates CD4+ effector memory T-cell activity of patients with granulomatosis with polyangiitis

E. Muñoz-Elías, P. Heeringa, W. Abdulahad, 2023, Rheumatology.

Evidence for enhanced Bruton’s tyrosine kinase activity in transitional and naïve B cells of patients with granulomatosis with polyangiitis

P. Heeringa, J. Rip, R. Hendriks, 2019, Rheumatology.

Increased miR-142-3p Expression Might Explain Reduced Regulatory T Cell Function in Granulomatosis With Polyangiitis

T. Bijma, A. van den Berg, B. Kroesen, 2019, Front. Immunol..

CD27+CD38hi B Cell Frequency During Remission Predicts Relapsing Disease in Granulomatosis With Polyangiitis Patients

A. Diepstra, P. Heeringa, A. von Borstel, 2019, Front. Immunol..

Genetic loci of Staphylococcus aureus associated with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides

M. D. de Goffau, C. Kallenberg, J. V. van Dijl, 2017, Scientific Reports.

Prospective monitoring of in vitro produced PR3-ANCA does not improve relapse prediction in granulomatosis with polyangiitis

P. Heeringa, S. Arends, W. Abdulahad, 2017, PloS one.

Kv1.3 Channel Blockade Modulates the Effector Function of B Cells in Granulomatosis with Polyangiitis

E. Muñoz-Elías, P. Heeringa, W. Abdulahad, 2016, Front. Immunol..

Toll-like receptor 9 activation enhances B cell activating factor and interleukin-21 induced anti-proteinase 3 autoantibody production in vitro.

C. Kallenberg, P. Heeringa, W. Abdulahad, 2016, Rheumatology.

Regulatory and effector B cell cytokine production in patients with relapsing granulomatosis with polyangiitis

P. Heeringa, W. Abdulahad, C. Stegeman, 2016, Arthritis Research & Therapy.

Infectious triggers for vasculitis

C. Kallenberg, P. Heeringa, M. V. van Timmeren, 2014, Current opinion in rheumatology.

Altered B cell balance, but unaffected B cell capacity to limit monocyte activation in anti-neutrophil cytoplasmic antibody-associated vasculitis in remission.

C. Kallenberg, P. Heeringa, W. Abdulahad, 2014, Rheumatology.

Differential Expression of Granulopoiesis Related Genes in Neutrophil Subsets Distinguished by Membrane Expression of CD177

C. Kallenberg, J. Westra, P. Heeringa, 2011, PloS one.

Treatment with Anti-HMGB1 Monoclonal Antibody Does Not Affect Lupus Nephritis in MRL/lpr Mice

P. Limburg, M. Bijl, J. Westra, 2016, Molecular medicine.

University of Groningen Treatment with Anti-HMGB1 Monoclonal Antibody Does Not Affect Lupus Nephritis in MRL/lpr Mice

P. Limburg, M. Bijl, J. Westra, 2016 .

Treatment with anti-HMGB 1 monoclonal antibody does not affect lupus nephritis in MRL / lpr mice

M. Bijl, J. Westra, P. Heeringa, 2016 .

Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing

P. Boor, G. Hartmann, P. Lyons, 2022, bioRxiv.

Effect of Benfotiamine on Advanced Glycation Endproducts and Markers of Endothelial Dysfunction and Inflammation in Diabetic Nephropathy

R. Gans, G. Navis, S. Bakker, 2012, PloS one.

Inhibition of complement factor C5 protects against renal ischemia-reperfusion injury: inhibition of late apoptosis and inflammation1

P. Heeringa, W. Buurman, R. Matthijsen, 2003, Transplantation.

Bone marrow transplantations to study gene function in hematopoietic cells.

P. Heeringa, M. D. de Winther, 2003, Methods in molecular biology.

Mediators of Obesity Do Not Influence SARS-CoV-2 Infection or Activation of Primary Human Lung Microvascular Endothelial Cells In Vitro

M. van Meurs, P. V. D. van der Voort, J. Moser, 2022, Frontiers in Immunology.

Bone marrow transplantations to study gene function in hematopoietic cells.

P. Heeringa, M. D. de Winther, 2011, Methods in molecular biology.

Leukocyte CD40L deficiency affects the CD25(+) CD4 T cell population but does not affect atherosclerosis.

L. Beckers, M. Daemen, P. Heeringa, 2005, Atherosclerosis.

Opposite Regulation of Type II and III Receptors for Immunoglobulin G in Mouse Glomerular Mesangial Cells and in the Induction of Anti-glomerular Basement Membrane (GBM) Nephritis*

P. Heeringa, R. Schmidt, H. Radeke, 2002, The Journal of Biological Chemistry.

A Distinct Macrophage Subset Mediating Tissue Destruction and Neovascularization in Giant Cell Arteritis: Implication of the YKL‐40/Interleukin‐13 Receptor α2 Axis

P. Heeringa, A. Boots, E. Brouwer, 2021, Arthritis & rheumatology.

A Distinct Macrophage Subset Mediating Tissue Destruction and Neovascularization in Giant Cell Arteritis: Implication of the YKLâ•’40 â•’ ILâ•’13 Receptor Î±2 Axis

Brouwer, P. Heeringa, A. Boots, 2021 .

Distinct macrophage phenotypes skewed by local granulocyte macrophage colony‐stimulating factor (GM‐CSF) and macrophage colony‐stimulating factor (M‐CSF) are associated with tissue destruction and intimal hyperplasia in giant cell arteritis

P. Heeringa, A. Boots, E. Brouwer, 2020, Clinical & translational immunology.

Decreased Expression of Negative Immune Checkpoint VISTA by CD4+ T Cells Facilitates T Helper 1, T Helper 17, and T Follicular Helper Lineage Differentiation in GCA

P. Heeringa, E. Brouwer, W. Abdulahad, 2019, Front. Immunol..

Review: What Is the Current Evidence for Disease Subsets in Giant Cell Arteritis?

C. Kallenberg, P. Heeringa, A. Boots, 2018, Arthritis & rheumatology.

University of Groningen Distinct macrophage phenotypes skewed by local granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) are associated with tissue destruction and intimal hyperplasia in giant cell arteritis

P. Heeringa, A. Boots, E. Brouwer, 2020 .

Comment on: Plasma Pyruvate Kinase M2 as a marker of vascular inflammation in giant cell arteritis: reply

P. Nienhuis, P. Heeringa, R. Slart, 2022, Rheumatology.

Aberrant pd-1 and vista expression on cd4+th-cells in giant cell arteritis

P. Heeringa, A. Boots, E. Brouwer, 2019 .

AB0033 AGE AND GENDER EFFECTS ON PROGRAMMED CELL DEATH-1 EXPRESSION IN HEALTHY DONORS

P. Heeringa, A. Boots, E. Brouwer, 2019 .

OP0049 Aberrant vista expression on cd45ra+cd25dim th-cells in giant cell arteritis

P. Heeringa, A. Boots, E. Brouwer, 2018, WEDNESDAY, 13 JUNE 2018.

Association of the CXCL9-CXCR3 and CXCL13-CXCR5 axes with B-cell trafficking in giant cell arteritis and polymyalgia rheumatica.

P. Heeringa, A. Boots, E. Brouwer, 2021, Journal of autoimmunity.

Autoantibodies vex the vasculature

C. Kallenberg, P. Heeringa, C. Stegeman, 2008, Nature Medicine.

Decreased CXCR1 and CXCR2 expression on neutrophils in anti-neutrophil cytoplasmic autoantibody-associated vasculitides potentially increases neutrophil adhesion and impairs migration

J. Westra, P. Heeringa, S. Satchell, 2011, Arthritis research & therapy.

Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis.

P. Heeringa, S. Satchell, M. Saleem, 2010, Kidney international.

Intracellular RIG-I Signaling Regulates TLR4-Independent Endothelial Inflammatory Responses to Endotoxin

M. van Meurs, W. Aird, I. A. D. de Graaf, 2016, The Journal of Immunology.

Cardiovascular, Pulmonary and Renal Pathology Myeloperoxidase Is Critically Involved in the Induction of Organ Damage after Renal Ischemia Reperfusion

M. Daha, P. Heeringa, W. Buurman, 2007 .

Age-dependent Role of Microvascular Endothelial and Polymorphonuclear Cells in Lipopolysaccharide-induced Acute Kidney Injury

M. van Meurs, M. Struys, G. Molema, 2012, Anesthesiology.

Complement is crucial in the pathogenesis of ANCA-associated vasculitis.

C. Kallenberg, P. Heeringa, 2013, Kidney international.

In vivo approaches to investigate ANCA-associated vasculitis: lessons and limitations

P. Heeringa, M. Little, 2011, Arthritis research & therapy.

ANCA‐small vessel vasculitides: what have we (not yet) learned from animal models?

P. Heeringa, B. S. van der Veen, 2009, APMIS. Supplementum.

C5a primes neutrophils for ANCA-mediated activation: role of P38 mitogen-activated protein kinase

Min Chen, C. Kallenberg, P. Heeringa, 2009 .

University of Groningen In vivo approaches to investigate ANCA-associated vasculitis

P. Heeringa, 2022 .

Effects of p38 mitogen-activated protein kinase inhibition on anti-neutrophil cytoplasmic autoantibody pathogenicity in vitro and in vivo

G. Molema, P. Heeringa, J. Zwerina, 2010, Annals of the rheumatic diseases.

Effects of p 38 mitogen-activated protein kinase inhibition on anti-neutrophil cytoplasmic autoantibody pathogenicity in vitro and in vivo

G. Molema, P. Heeringa, J. Zwerina, 2022 .

Contribution of pathogenic T helper 1 and 17 cells to bursitis and tenosynovitis in polymyalgia rheumatica

T. Kwee, A. Diepstra, P. Heeringa, 2022, Frontiers in Immunology.

Bacterial infections in Wegener's granulomatosis: mechanisms potentially involved in autoimmune pathogenesis

C. Kallenberg, P. Heeringa, H. Tadema, 2011, Current opinion in rheumatology.

University of Groningen Differential expression of granulopoiesis related genes in neutrophil subsets distinguished by membrane expression of CD177 Hu,

C. Kallenberg, J. Westra, P. Heeringa, 2014 .

Angiopoietin-2/-1 ratios and MMP-3 levels as an early warning sign for the presence of giant cell arteritis in patients with polymyalgia rheumatica

P. Heeringa, A. Boots, E. Hauge, 2022, Arthritis Research & Therapy.

Podocyte expression of MHC class I and II and intercellular adhesion molecule‐1 (ICAM‐1) in experimental pauci‐immune crescentic glomerulonephritis

C. Kallenberg, P. Heeringa, A. Chand, 1994, Clinical and experimental immunology.

Bacterial DNA motifs trigger ANCA production in ANCA-associated vasculitis in remission.

C. Kallenberg, P. Heeringa, W. Abdulahad, 2011, Rheumatology.

Neutrophil activation in vitro and in vivo in Wegener's granulomatosis.

C. Kallenberg, P. Heeringa, H. van Goor, 1994, Kidney international.

Myeloperoxidase modulates lung epithelial responses to pro-inflammatory agents

P. Heeringa, B. Mossman, E. Wouters, 2008, European Respiratory Journal.

Lack of IL-17 Receptor A signaling aggravates lymphoproliferation in C57BL/6 lpr mice

J. Westra, P. Heeringa, R. Hendriks, 2019, Scientific Reports.

University of Groningen CD27(+)CD38(hi) B Cell Frequency During Remission Predicts Relapsing Disease in Granulomatosis With Polyangiitis Patients von Borstel,

A. Diepstra, P. Heeringa, W. Abdulahad, 2019 .

Sustained protective effects of 7-monohydroxyethylrutoside in an in vivo model of cardiac ischemia-reperfusion.

A. Bast, P. Heeringa, B. Janssen, 2004, European journal of pharmacology.

Hematopoietic NF- (cid:1) B1 deﬁciency results in small atherosclerotic lesions with an inﬂammatory phenotype

P. Heeringa, M. Hofker, M. Gijbels, 2004 .

Dendritic cells overexpressing Fas‐ligand induce pulmonary vasculitis in mice

P. Heeringa, M. Goldman, V. Flamand, 2004, Clinical and experimental immunology.

CIRCULATING CD24HICD38HI REGULATORY B-CELLS CORRELATE INVERSELY WITH THE FREQUENCY OF THEM17-CELLS IN GRANULOMATOSIS WITH POLYANGIITIS PATIENTS

P. Heeringa, W. Abdulahad, C. Stegeman, 2019 .

Immune regulatory mechanisms in ANCA-associated vasculitides.

C. Kallenberg, P. Heeringa, W. Abdulahad, 2011, Autoimmunity reviews.

Animal models of anti-neutrophil cytoplasmic antibody associated vasculitis.

C. Kallenberg, P. Heeringa, E. Brouwer, 1998, Kidney international.

Activation of granulocytes by anti‐neutrophil cytoplasmic antibodies (ANCA): a FcγRII‐dependent process

P. Limburg, P. Heeringa, E. Brouwer, 1994, Clinical and experimental immunology.

IgG glycan hydrolysis attenuates ANCA-mediated glomerulonephritis.

P. Heeringa, A. Petersen, M. V. van Timmeren, 2010, Journal of the American Society of Nephrology : JASN.

Exogenous alpha-1-Acid Glycoprotein Protects against Renal Ischemia-Reperfusion Injury by Inhibition of Inflammation and Apoptosis

C. Libert, P. Heeringa, W. Buurman, 2004, Transplantation.

The renal angiopoietin/Tie2 system in lethal human sepsis

M. van Meurs, A. Diepstra, G. Molema, 2014, Critical Care.

Mechanisms of Vasculitis: How Pauci-Immune Is ANCA-Associated Renal Vasculitis?

P. van Paassen, P. Heeringa, J. C. Cohen Tervaert, 2006, Nephron Experimental Nephrology.

Antineutrophil cytoplasmic autoantibodies and pathophysiology: new insights from animal models

P. Heeringa, J. Tervaert, D. Huugen, 2004, Current opinion in rheumatology.

Coating and Corruption of Human Neutrophils by Bacterial Outer Membrane Vesicles

J. V. van Dijl, D. Becher, P. Heeringa, 2022, Microbiology spectrum.

Elastase, but not proteinase 3 (PR3), induces proteinuria associated with loss of glomerular basement membrane heparan sulphate after in vivo renal perfusion in rats

P. Heeringa, J. van den Born, K. Dolman, 1996, Clinical and experimental immunology.

Spatiotemporal expression of chemokines and chemokine receptors in experimental anti‐myeloperoxidase antibody‐mediated glomerulonephritis

G. Molema, P. Heeringa, S. Satchell, 2009, Clinical and experimental immunology.

CD163 and CD206 expression define distinct macrophage subsets involved in active ANCA-associated glomerulonephritis.

P. van Paassen, P. Heeringa, J. Damoiseaux, 2022, Journal of autoimmunity.

Role of oxidized low-density lipoprotein in renal disease

P. Heeringa, J. C. Cohen Tervaert, 2002, Current opinion in nephrology and hypertension.

L8. Animal models of ANCA associated vasculitis: the contribution of autoantibodies and autoreactive T cells.

P. Heeringa, 2013, Presse medicale.

The IgM Response to Modified LDL in Experimental Atherosclerosis

P. Heeringa, J. Damoiseaux, M. Gijbels, 2009, Annals of the New York Academy of Sciences.

The net effect of ANCA on neutrophil extracellular trap formation.

C. Kallenberg, P. Heeringa, A. Rutgers, 2018, Kidney international.

Anti-neutrophil cytoplasmic autoantibodies and leukocyte-endothelial interactions: a sticky connection?

P. Heeringa, J. Tervaert, D. Huugen, 2005, Trends in immunology.

Reduction in glomerular heparan sulfate correlates with complement deposition and albuminuria in active Heymann nephritis.

P. Heeringa, Emile de Heer, A. M. van der Wal, 1999, Journal of the American Society of Nephrology : JASN.

University of Groningen Kv 1 . 3 channel Blockade Modulates the effector Function of B cells in granulomatosis with Polyangiitis Land

E. Muñoz-Elías, P. Heeringa, W. Abdulahad, 2018 .

CONTEMPORARY CHALLENGES IN AUTOIMMUNITY

P. Heeringa, J. Damoiseaux, M. Gijbels, 2009 .

Phenotypic, transcriptomic and functional profiling reveal reduced activation thresholds of CD8+ T cells in giant cell arteritis

P. Heeringa, E. Brouwer, W. Abdulahad, 2022, Rheumatology.

A protective role for endothelial nitric oxide synthase in glomerulonephritis.

P. Heeringa, H. van Goor, E. Steenbergen, 2002, Kidney international.

Nitric oxide inhibition enhances platelet aggregation in experimental anti-Thy-1 nephritis.

P. Heeringa, H. van Goor, H. Moshage, 2001, Nitric oxide : biology and chemistry.

Lack of endothelial nitric oxide synthase aggravates murine accelerated anti-glomerular basement membrane glomerulonephritis.

C. Kallenberg, P. Heeringa, H. van Goor, 2000, The American journal of pathology.

Inhibition of neutrophil‐mediated production of reactive oxygen species (ROS) by endothelial cells is not impaired in anti‐neutrophil cytoplasmic autoantibodies (ANCA)‐associated vasculitis patients

P. Heeringa, B. Yard, C. Kallenberg, 2010, Clinical and experimental immunology.

Are Antineutrophil Cytoplasmic Antibodies Pathogenic in Wegener’s Granulomatosis? Lessons From In Vitro and In Vivo Experimental Findings

P. Heeringa, C. Kallenberg, J. Tervaert, 1999 .

Recombinant proteinase 3 (Wegener's antigen) expressed in Pichia pastoris is functionally active and is recognized by patient sera

P. Heeringa, C. Kallenberg, M. Harmsen, 1997, Clinical and experimental immunology.

FRI0266 ABERRANT PD-1 AND VISTA EXPRESSION ON CD4+ TH-CELLS IN GIANT CELL ARTERITIS

P. Heeringa, A. Boots, E. Brouwer, 2019, Poster Presentations.

Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice.

P. Heeringa, N. Maeda, R. Falk, 2002, The Journal of clinical investigation.

22nd European Congress on Obesity (ECO2015), Prague, Czech Republic, May 6-9, 2015: Abstracts

J. N. Fidalgo, Jimmy D Bell, L. S. Silveira, 2015, Obesity Facts.

University of Groningen Mycophenolic acid and 6-mercaptopurine both inhibit B-cell proliferation in granulomatosis with polyangiitis patients, whereas only mycophenolic acid inhibits B-cell IL-6 production von Borstel,

P. Heeringa, W. Abdulahad, C. Stegeman, 2020 .

KV 1 . 3 CHANNEL BLOCKADE MODULATES THE EFFECTOR FUNCTION OF B CELLS IN GRANULOMATOSIS WITH POLYANGIITIS CHAPTER 5

E. Muñoz-Elías, P. Heeringa, C. Stegeman, 2019 .

The dual role of interleukin-10 in in vitro production of anti-neutrophil cytoplasmic antibodies

P. Heeringa, P. Evers, W. Abdulahad, 2016 .

Circulating adipokine levels and COVID-19 severity in hospitalized patients

M. van Meurs, P. V. D. van der Voort, J. Moser, 2022, International Journal of Obesity.

Inhibition of high-mobility group box 1 as therapeutic option in autoimmune disease: lessons from animal models

M. Bijl, J. Westra, P. Heeringa, 2013, Current opinion in rheumatology.

Myeloperoxidase: molecular mechanisms of action and their relevance to human health and disease.

P. Heeringa, M. D. de Winther, B. S. van der Veen, 2009, Antioxidants & redox signaling.

Review article: Pathogenic role of complement activation in anti‐neutrophil cytoplasmic auto‐antibody‐associated vasculitis

Min Chen, P. Heeringa, M. V. van Timmeren, 2009, Nephrology.

Coexistence of anti-glomerular basement membrane antibodies and myeloperoxidase-ANCAs in crescentic glomerulonephritis.

P. van Paassen, P. Heeringa, J. Tervaert, 2005, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Internalization of proteinase 3 is concomitant with endothelial cell apoptosis and internalization of myeloperoxidase with generation of intracellular oxidants.

P. Heeringa, R. Falk, J. Jennette, 2001, The American journal of pathology.

An adapted passive model of anti-MPO dependent crescentic glomerulonephritis reveals matrix dysregulation and is amenable to modulation by CXCR4 inhibition.

O. Schilling, P. Heeringa, H. Schachner, 2022, Matrix biology : journal of the International Society for Matrix Biology.

Myeloperoxidase Deficiency Attenuates Lipopolysaccharide-Induced Acute Lung Inflammation and Subsequent Cytokine and Chemokine Production1

E. Wouters, P. Heeringa, S. Mutsaers, 2009, The Journal of Immunology.

Autoantibodies to box A of high mobility group box 1 in systemic lupus erythematosus

P. Limburg, J. Westra, P. Heeringa, 2017, Clinical and experimental immunology.

The Mitogen-Activated Protein Kinase p38α Regulates Tubular Damage in Murine Anti-Glomerular Basement Membrane Nephritis

P. Heeringa, J. Zwerina, C. Daniel, 2013, PloS one.

Myeloperoxidase attracts neutrophils by physical forces.

M. Sperandio, U. Schumacher, T. Meinertz, 2011, Blood.

Urinary Soluble CD163 and Disease Activity in Biopsy-Proven ANCA-Associated Glomerulonephritis.

C. Reutelingsperger, P. van Paassen, P. Heeringa, 2020, Clinical journal of the American Society of Nephrology : CJASN.

Urinary and serum soluble CD25 complements urinary soluble CD163 to detect active renal anti-neutrophil cytoplasmic autoantibody-associated vasculitis: a cohort study

T. Bijma, P. Heeringa, W. Abdulahad, 2019, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Genetic analysis of mesangial matrix expansion in aging mice and identification of Far2 as a candidate gene.

R. Korstanje, P. Heeringa, H. van Goor, 2013, Journal of the American Society of Nephrology : JASN.

Dual effect of chemokine CCL7/MCP-3 in the development of renal tubulointerstitial fibrosis.

J. Schanstra, P. Heeringa, J. Pradère, 2013, Biochemical and biophysical research communications.

Protective role of endothelial nitric oxide synthase

R. Henning, P. Heeringa, H. van Goor, 2003, The Journal of pathology.

Blockade of the kinin B1 receptor ameloriates glomerulonephritis.

D. Salant, J. Schanstra, P. Heeringa, 2010, Journal of the American Society of Nephrology : JASN.

Alternative complement pathway in the pathogenesis of disease mediated by anti-neutrophil cytoplasmic autoantibodies.

P. Heeringa, R. Falk, J. Jennette, 2007, The American journal of pathology.

Cellular immune regulation in the pathogenesis of ANCA-associated vasculitides.

P. Heeringa, A. von Borstel, W. Abdulahad, 2018, Autoimmunity reviews.

Complement Factor C5a Mediates Renal Ischemia-Reperfusion Injury Independent from Neutrophils1

J. Köhl, P. Heeringa, W. Buurman, 2003, The Journal of Immunology.

MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation.

M. van Meurs, T. Rabelink, B. Banas, 2012, American journal of physiology. Renal physiology.

High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice

R. Kleemann, A. de Bruin, P. Heeringa, 2015, Aging.

Reduced levels of cytosolic DNA sensor AIM2 are associated with impaired cytokine responses in healthy elderly

L. Joosten, M. Netea, J. Moser, 2016, Experimental Gerontology.

T Cells in Vascular Inflammatory Diseases

P. Heeringa, W. Abdulahad, C. Stegeman, 2014, Front. Immunol..

M2 macrophage is the predominant phenotype in airways inflammatory lesions in patients with granulomatosis with polyangiitis

C. Kallenberg, J. Westra, P. Heeringa, 2017, Arthritis Research & Therapy.

CD8+ T Cells in GCA and GPA: Bystanders or Active Contributors?

P. Heeringa, A. Boots, E. Brouwer, 2021, Frontiers in Immunology.

Lack of IL-17 Receptor A signaling aggravates lymphoproliferation in C57BL/6 lpr mice

J. Westra, P. Heeringa, R. Hendriks, 2019, Scientific Reports.

Endothelial IRF-1 regulates LPS-induced VCAM-1 expression independent of NF-κB

J. Kamps, G. Molema, P. Zwiers, 2019 .

Endothelial Interferon Regulatory Factor 1 Regulates Lipopolysaccharide-Induced VCAM-1 Expression Independent of NFκB

M. van Meurs, J. Kamps, G. Molema, 2017, Journal of Innate Immunity.

Intermediate monocytes in ANCA vasculitis: increased surface expression of ANCA autoantigens and IL-1β secretion in response to anti-MPO antibodies

P. Heeringa, W. Abdulahad, M. Huitema, 2015, Scientific Reports.

Epitope specificity determines pathogenicity and detectability in ANCA-associated vasculitis.

P. Heeringa, S. Holdsworth, Yichun Hu, 2013, The Journal of clinical investigation.

Urinary Soluble CD163 in Active Renal Vasculitis.

C. Feighery, C. Cohen, E. Connolly, 2016, Journal of the American Society of Nephrology : JASN.

Expression of interleukin-6 in synovial tissue of patients with polymyalgia rheumatica

A. Diepstra, P. Heeringa, E. Brouwer, 2022, Annals of the Rheumatic Diseases.

Hematopoietic NF-kappaB1 deficiency results in small atherosclerotic lesions with an inflammatory phenotype.

I. van der Made, P. Heeringa, M. Hofker, 2004, Blood.

Renal Klotho is Reduced in Septic Patients and Pretreatment With Recombinant Klotho Attenuates Organ Injury in Lipopolysaccharide-Challenged Mice

M. van Meurs, G. Molema, J. Moser, 2018, Critical care medicine.

University of Groningen Renal Klotho is Reduced in Septic Patients and Pretreatment With Recombinant Klotho Attenuates Organ Injury in Lipopolysaccharide-Challenged Mice Jou-Valencia,

G. Molema, J. Moser, J. Zijlstra, 2018 .

Renal Klotho is Reduced

G. Molema, J. Moser, J. Zijlstra, 2018 .

Chemokine receptor co-expression reveals aberrantly distributed TH effector memory cells in GPA patients

P. Heeringa, W. Abdulahad, C. Stegeman, 2017, Arthritis Research & Therapy.

Genetic Analysis of Intracapillary Glomerular Lipoprotein Deposits in Aging Mice

M. V. van Dijk, R. Korstanje, P. Heeringa, 2014, PloS one.

Increased Expression of Inducible Nitric Oxide Synthase in Circulating Monocytes from Patients with Active Inflammatory Bowel Disease

P. Heeringa, H. Goor, G. Dijkstra, 2002, Scandinavian journal of gastroenterology.

University of Groningen The Mitogen-Activated Protein Kinase p38 alpha Regulates Tubular Damage in Murine Anti- Glomerular Basement Membrane Nephritis

P. Heeringa, J. Zwerina, C. Daniel, 2013 .

Reactivity against Complementary Proteinase-3 Is Not Increased in Patients with PR3-ANCA-Associated Vasculitis

C. Kallenberg, P. Heeringa, C. Stegeman, 2011, PloS one.

Effects of chocolate supplementation on metabolic and cardiovascular parameters in ApoE3L mice fed a high-cholesterol atherogenic diet.

T. Kooistra, R. Kleemann, P. Heeringa, 2013, Molecular nutrition & food research.

University of Groningen Beneficial Effects of Alternate Dietary Regimen on Liver Inflammation, Atherosclerosis and Renal Activation Wielinga,

T. Kooistra, R. Kleemann, P. Heeringa, 2012 .

Beneficial Effects of Alternate Dietary Regimen on Liver Inflammation, Atherosclerosis and Renal Activation

T. Kooistra, R. Kleemann, P. Heeringa, 2011, PloS one.

Epicatechin attenuates atherosclerosis and exerts anti-inflammatory effects on diet-induced human-CRP and NFκB in vivo.

T. Kooistra, R. Kleemann, P. Heeringa, 2014, Atherosclerosis.

Accumulation of Myeloperoxidase-Positive Neutrophils in Atherosclerotic Lesions in LDLR−/− Mice

P. Heeringa, M. Gijbels, A. Duijvestijn, 2007, Arteriosclerosis, thrombosis, and vascular biology.

Increased Expression of Toll-Like Receptors by Monocytes and Natural Killer Cells in ANCA-Associated Vasculitis

C. Kallenberg, P. Heeringa, W. Abdulahad, 2011, PloS one.

Involvement of Monocyte Subsets in the Immunopathology of Giant Cell Arteritis

J. Westra, P. Heeringa, E. Brouwer, 2017, Scientific Reports.

University of Groningen Involvement of Monocyte Subsets in the Immunopathology of Giant Cell Arteritis

J. Westra, P. Heeringa, A. Boots, 2017 .

Positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging of macrophages in large vessel vasculitis: Current status and future prospects.

J. Kamps, P. Heeringa, R. Slart, 2018, Autoimmunity reviews.

Shock-induced stress induces loss of microvascular endothelial Tie2 in the kidney which is not associated with reduced glomerular barrier function.

M. van Meurs, I. A. D. de Graaf, G. Molema, 2009, American journal of physiology. Renal physiology.

Increased frequency of circulating IL-21 producing Th-cells in patients with granulomatosis with polyangiitis (GPA)

C. Kallenberg, P. Limburg, P. Heeringa, 2013, Arthritis Research & Therapy.

The flow dependency of Tie2 expression in endotoxemia

H. Hammes, W. Aird, M. Struys, 2013, Intensive Care Medicine.

Mechanisms of ANCA-mediated leukocyte-endothelial cell interactions in vivo.

N. Kalia, P. Heeringa, C. Savage, 2008, Journal of the American Society of Nephrology : JASN.

SAT0012 DETECTION OF CIRCULATING PR3-SPECIFIC B CELLS IN PATIENTS WITH ACTIVE ANCA-ASSOCIATED VASCULITIS

P. Merkel, J. Stone, J. Pers, 2019, SATURDAY, 15 JUNE 2019.

Giant worm-shaped ESCRT scaffolds surround actin-independent integrin clusters

Julian N. Selley, G. van den Bogaart, P. Heeringa, 2023, The Journal of cell biology.

Unraveling the identity of FoxP3+ regulatory T cells in Granulomatosis with Polyangiitis patients

P. Heeringa, W. Abdulahad, C. Stegeman, 2019, Scientific Reports.

Low anti-staphylococcal IgG responses in granulomatosis with polyangiitis patients despite long-term Staphylococcus aureus exposure

M. D. de Goffau, C. Kallenberg, J. V. van Dijl, 2015, Scientific Reports.

SYSTEMIC INJECTION OF MYELOPEROXIDASE IN MYELOPEROXIDASEIMMUNIZED BROWN-NORWAY RATS

P. Heeringa, C. Kallenberg, M. Huitema, 1995 .

Identification of Novel Genes Associated with Renal Tertiary Lymphoid Organ Formation in Aging Mice

R. Korstanje, P. Heeringa, J. van den Born, 2014, PloS one.

Site-Specific Inhibition of Glomerulonephritis Progression by Targeted Delivery of Dexamethasone to Glomerular Endothelium

C. Kallenberg, J. Kamps, G. Molema, 2007, Molecular Pharmacology.

Age‐determined severity of anti‐myeloperoxidase autoantibody‐mediated glomerulonephritis in mice

J. Moser, J. Westra, P. Heeringa, 2016, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Circulating autoreactive proteinase 3+ B cells and tolerance checkpoints in ANCA-associated vasculitis

P. Merkel, J. Stone, C. Kallenberg, 2021, JCI insight.

Corrigendum: Shock-induced stress induces loss of microvascular endothelial Tie2 in the kidney which is not associated with reduced glomerular barrier function (vol 297, pg F272, 2009)

G. Molema, J. Zijlstra, M. Meurs, 2017 .

OP0015 PROINFLAMMATORY MONOCYTES AND MACROPHAGES IN SYNOVIAL FLUID AND BURSAL TISSUE OF PATIENTS WITH POLYMYALGIA RHEUMATICA: POTENT PRODUCERS OF IL-6 AND GM-CSF

P. Heeringa, M. Sandovici, E. Brouwer, 2022, Annals of the Rheumatic Diseases.

FRI0510 Increased expression of v-domain ig suppressor of t-cell activation (VISTA) on leukocytes of granulomatosis with polyangiitis (GPA) patients

P. Heeringa, A. Boots, E. Brouwer, 2017, FRIDAY, 15 JUNE 2018.

Involvement of MicroRNAs in the Aging-Related Decline of CD28 Expression by Human T Cells

K. Kok, G. Pawelec, A. van den Berg, 2018, Front. Immunol..

Co-expression of CD177 and membrane proteinase 3 on neutrophils in ANCA-associated vasculitis: Anti-PR3 mediated neutrophil activation is independent of CD177 expression

C. Kallenberg, P. Limburg, M. Bijl, 2008 .

inflammationof VCAM-1 protein expression in acute MicroRNA-126 contributes to renal microvascular

T. Rabelink, B. Banas, P. Zwiers, 2012 .

High genetic diversity in nasal Staphylococcus aureus isolates from Granulomatosis with Polyangiitis (GPA) patients

P. Heeringa, J. M. Dijl, J. Rossen, 2013 .

Cytokine producing B-cells and their capability to polarize macrophages in giant cell arteritis.

P. Heeringa, E. Brouwer, W. Abdulahad, 2023, Journal of autoimmunity.

Alternative complement pathway in the pathogenesis of disease mediated by anti-neutrophil cytoplasmic autoantibodies.

P. Heeringa, J. Jennette, Hong Xiao, 2007, The American journal of pathology.

Pathophysiology of ANCA-associated vasculitides: are ANCA really pathogenic?

P. Heeringa, J. Tervaert, 2004, Kidney international.

Dual effect of chemokine CCL7/MCP-3 in the development of renal tubulointerstitial fibrosis.

J. Schanstra, P. Heeringa, J. Pradère, 2013, Biochemical and biophysical research communications.

Positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging of macrophages in large vessel vasculitis: Current status and future prospects.

J. Kamps, P. Heeringa, R. Slart, 2018, Autoimmunity reviews.

Complement Activation Is Involved in Renal Damage in Human Antineutrophil Cytoplasmic Autoantibody Associated Pauci-Immune Vasculitis

Min Chen, C. Kallenberg, P. Heeringa, 2009, Journal of Clinical Immunology.

Checks and Balances in Autoimmune Vasculitis

G. Hospers, P. Heeringa, A. Boots, 2018, Front. Immunol..

Review article: Pathogenic role of complement activation in anti‐neutrophil cytoplasmic auto‐antibody‐associated vasculitis

Min Chen, P. Heeringa, M. V. van Timmeren, 2009, Nephrology.

Releasing the complement brakes: is myeloperoxidase the missing link between factor H and C5a in anti-neutrophil cytoplasmic antibody vasculitis?

P. Heeringa, Mark Alan Little, 2018, Rheumatology.

Complement is crucial in the pathogenesis of ANCA-associated vasculitis.

C. Kallenberg, P. Heeringa, 2013, Kidney international.

Inhibition of high-mobility group box 1 as therapeutic option in autoimmune disease: lessons from animal models

M. Bijl, J. Westra, P. Heeringa, 2013, Current opinion in rheumatology.

Mechanisms and pathophysiology of SARS-CoV-2 infection of the adipose tissue

P. Heeringa, M. Emous, Izabela A. Rodenhuis-Zybert, 2023, Trends in Endocrinology & Metabolism.

Pathogenetic and clinical aspects of ANCA-associated vasculitis

Min Chen, P. Heeringa, M. M. Timmeren, 2009 .

Interleukin-21, B cell activating factor and unmethylated CpG oligodeoxynucleotides synergize in promoting anti-Proteinase 3 autoantibody production in vitro

P. Heeringa, C. Kallenberg, W. Abdulahad, 2013 .

Increased Expression of Toll-Like Receptors by Monocytes and Natural Killer Cells in ANCA-Associated Vasculitis

C. Kallenberg, P. Heeringa, W. Abdulahad, 2011, PloS one.

Neutrophil myeloperoxidase activity and the influence of two single‐nucleotide promoter polymorphisms

P. Heeringa, J. Tervaert, R. Theunissen, 2003, British journal of haematology.

Effects of propofol and dexmedetomidine with and without remifentanil on serum cytokine concentrations in healthy volunteers: a post hoc analysis.

M. Struys, M. Meurs, P. Heeringa, 2020, British journal of anaesthesia.

Inflammation and Subsequent Cytokine and Lipopolysaccharide-Induced Acute Lung Myeloperoxidase Deficiency Attenuates

P. Heeringa, S. Mutsaers, B. Mossman, 2013 .

Mirtoselect, an anthocyanin-rich bilberry extract, attenuates non-alcoholic steatohepatitis and associated fibrosis in ApoE(∗)3Leiden mice.

T. Kooistra, R. Kleemann, P. Heeringa, 2015, Journal of hepatology.

Abstract 441: Epicatechin Attenuates Atherosclerosis and Exerts Anti-inflammatory Effects on Diet-Induced Human CRP and NfκB in vivo

T. Kooistra, R. Kleemann, P. Heeringa, 2014, Arteriosclerosis, Thrombosis, and Vascular Biology.

Transforming growth factor-beta mediates balance between inflammation and fibrosis during plaque progression.

M. Daemen, V. Koteliansky, P. Heeringa, 2002, Arteriosclerosis, thrombosis, and vascular biology.

Increased Frequency of Circulating Follicular Helper T-Cells (T-FH) in Patients with Granulomatosis with Polyangiitis.

C. Kallenberg, P. Limburg, P. Heeringa, 2011 .

Urinary Soluble CD163 in Active Renal Vasculitis.

C. Feighery, C. Cohen, E. Connolly, 2016, Journal of the American Society of Nephrology : JASN.

Specific IgG glycosylation differences precede relapse in PR3-ANCA associated vasculitis patients with and without ANCA rise

P. Heeringa, D. Falck, C. Stegeman, 2023, Frontiers in immunology.

Pathophysiology of ANCA-associated vasculitides: are ANCA really pathogenic?

P. Heeringa, J. Tervaert, 2003, The Netherlands journal of medicine.

Aberrant phenotype of circulating antigen presenting cells in giant cell arteritis and polymyalgia rheumatica

P. Heeringa, E. Brouwer, W. Abdulahad, 2023, Frontiers in immunology.

Metabolic features and glucocorticoid-induced comorbidities in patients with giant cell arteritis and polymyalgia rheumatica in a Dutch and Danish cohort

P. Heeringa, E. Hauge, E. Brouwer, 2023, RMD Open.

Impaired IL-6-induced JAK-STAT signaling in CD4+ T cells associates with longer treatment duration in giant cell arteritis.

P. Heeringa, W. Abdulahad, M. Sandovici, 2024, Journal of autoimmunity.

SAT0232 DISTRIBUTION OF MACROPHAGE SUBSETS IN TEMPORAL ARTERY BIOPSIES OF PATIENTS WITH GIANT CELL ARTERITIS

P. Heeringa, A. Boots, R. Slart, 2019, Saturday, 15 June 2019.