I. Helfrich

发表

Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma

D. Schadendorf, H. Augustin, I. Helfrich, 2010, The Journal of experimental medicine.

Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma

D. Schadendorf, J. Landsberg, J. Kohlmeyer, 2014, Nature.

Hyperlipidemia Attenuates Vascular Endothelial Growth Factor–Induced Angiogenesis, Impairs Cerebral Blood Flow, and Disturbs Stroke Recovery via Decreased Pericyte Coverage of Brain Endothelial Cells

A. Zechariah, G. Mies, D. Hermann, 2013, Arteriosclerosis, thrombosis, and vascular biology.

P Atients with Cerebrovascular Diseases Frequently Exhibit Chronic Hemodynamic Disturbances

A. Zechariah, G. Mies, D. Hermann, 2022 .

Tension in Cancer

I. Helfrich, Claus-Werner Franzke, S. Löffek, 2016, International journal of molecular sciences.

Tumorigenesis and Neoplastic Progression Endosialin ( Tem 1 ) Is a Marker of Tumor-Associated Myofibroblasts and Tumor Vessel-Associated Mural Cells

D. Schadendorf, E. Besemfelder, H. Augustin, 2010 .

Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth

D. Schadendorf, J. Buer, I. Helfrich, 2012, The Journal of experimental medicine.

Targeting X-Linked Inhibitor of Apoptosis Protein for Melanoma Therapy : The Need for More Homogeneous Samples and the Importance of Cell Lines

I. Helfrich, R. Johnson, A. Weidemann, 2011 .

Role of Acid Sphingomyelinase-Induced Signaling in Melanoma Cells for Hematogenous Tumor Metastasis

I. Helfrich, E. Gulbins, B. Edelmann, 2016, Cellular Physiology and Biochemistry.

guidance cues and negatively regulates sprouting of endothelial cells The VEGF-regulated transcription factor HLX controls the expression of

H. Augustin, I. Helfrich, R. Hofer-Warbinek, 2011 .

Impact of radiotherapy and sequencing of systemic therapy on survival outcomes in melanoma patients with previously untreated brain metastasis: a multicenter DeCOG study on 450 patients from the prospective skin cancer registry ADOREG

M. Weichenthal, J. Utikal, S. Haferkamp, 2022, Journal for ImmunoTherapy of Cancer.

Ex Vivo Exposure of Human Melanoma Tissue to Cold Physical Plasma Elicits Apoptosis and Modulates Inflammation

I. Helfrich, K. Weltmann, T. Woedtke, 2020, Applied Sciences.

Persister state-directed transitioning and vulnerability in melanoma

Samantha J. Stehbens, D. Schadendorf, J. Becker, 2020, Nature Communications.

Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth

J. Buer, I. Helfrich, S. Lang, 2017, Nature Communications.

Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma

D. Schadendorf, H. Augustin, I. Helfrich, 2010, The Journal of Experimental Medicine.

Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia

I. Helfrich, V. Sexl, A. Meinecke, 2016, Nature Communications.

Role of aPKC isoforms and their binding partners Par3 and Par6 in epidermal barrier formation.

A. Le Bivic, I. Helfrich, M. Leitges, 2007, The Journal of investigative dermatology.

Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis.

K. Alitalo, J. Fischer, I. Helfrich, 2012, Blood.

CEACAM1-3S Drives Melanoma Cells into NK Cell-Mediated Cytolysis and Enhances Patient Survival.

J. Klode, D. Schadendorf, A. Scherag, 2015, Cancer research.

Macrophages/Microglia Represent the Major Source of Indolamine 2,3-Dioxygenase Expression in Melanoma Metastases of the Brain

J. Klode, D. Schadendorf, P. Jansen, 2020, Frontiers in Immunology.

Targeting early stages of cardiotoxicity from anti-PD1 immune checkpoint inhibitor therapy.

D. Schadendorf, S. Ugurel, L. Umutlu, 2021, European heart journal.

Angiopoietin-2 Levels Are Associated with Disease Progression in Metastatic Malignant Melanoma

D. Schadendorf, Markus Thomas, H. Augustin, 2009, Clinical Cancer Research.

A wound size-dependent effect of myeloid cell-derived vascular endothelial growth factor on wound healing.

I. Helfrich, R. Johnson, A. Weidemann, 2011, The Journal of investigative dermatology.

Rapid and fully automated blood vasculature analysis in 3D light-sheet image volumes of different organs

A. Mosig, M. Gunzer, I. Helfrich, 2022, bioRxiv.

Vascular Endothelial Growth Factor Promotes Pericyte Coverage of Brain Capillaries, Improves Cerebral Blood Flow During Subsequent Focal Cerebral Ischemia,

A. Zechariah, G. Mies, I. Helfrich, 2013 .

Vascular Endothelial Growth Factor Promotes Pericyte Coverage of Brain Capillaries, Improves Cerebral Blood Flow During Subsequent Focal Cerebral Ischemia, and Preserves

A. Zechariah, G. Mies, I. Helfrich, 2013 .

Sequence‐Selective Covalent CaaX‐Box Receptors Prevent Farnesylation of Oncogenic Ras Proteins and Impact MAPK/PI3 K Signaling

D. Wolters, U. Koch, B. Klebl, 2021, ChemMedChem.

Persister state-directed transitioning and vulnerability in melanoma

Samantha J. Stehbens, D. Schadendorf, J. Becker, 2020, Nature Communications.

Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression

D. Schadendorf, M. Heikenwalder, A. Pandyra, 2017, Nature Communications.

Blood vessel maturation, vascular phenotype and angiogenic potential in malignant melanoma: One step forward for overcoming anti‐angiogenic drug resistance?

D. Schadendorf, I. Helfrich, 2011, Molecular oncology.

The Impact of the Immune System on Tumor: Angiogenesis and Vascular Remodeling

D. Schadendorf, I. Helfrich, C. Stockmann, 2014, Front. Oncol..

Host-derived angiopoietin-2 affects early stages of tumor development and vessel maturation but is dispensable for later stages of tumor growth.

D. Schadendorf, Markus Thomas, H. Augustin, 2009, Cancer research.

Targeting the “undruggable” RAS - new strategies - new hope?

Britta Mörchen, Oleksandr Shkura, Raphael Stoll, 2019, Cancer drug resistance.

Increased Incidence of Squamous Cell Carcinomas in Mastomys natalensis Papillomavirus E6 Transgenic Mice during Two-Stage Skin Carcinogenesis

A. Kopp-Schneider, F. Rösl, I. Helfrich, 2004, Journal of Virology.

E‐cadherin is essential for in vivo epidermal barrier function by regulating tight junctions

H. Schwarz, I. Helfrich, M. Fromm, 2005, The EMBO journal.

Phenotypic tumour cell plasticity as a resistance mechanism and therapeutic target in melanoma.

D. Schadendorf, J. Becker, J. Landsberg, 2016, European journal of cancer.

Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging

Dirk Schadendorf, Stefan Morscher, Neal C. Burton, 2015, Science Translational Medicine.

Regulation of hematogenous tumor metastasis by acid sphingomyelinase

K. Schmid, I. Helfrich, E. Gulbins, 2015, EMBO molecular medicine.

Integrative Genomic Analyses of Patient-Matched Intracranial and Extracranial Metastases Reveal a Novel Brain-Specific Landscape of Genetic Variants in Driver Genes of Malignant Melanoma

D. Schadendorf, G. Reifenberger, I. Helfrich, 2021, Cancers.

Size Matters: The Functional Role of the CEACAM1 Isoform Signature and Its Impact for NK Cell-Mediated Killing in Melanoma

I. Helfrich, B. Singer, 2019, Cancers.

The VEGF-regulated transcription factor HLX controls the expression of guidance cues and negatively regulates sprouting of endothelial cells.

H. Augustin, I. Helfrich, R. Hofer-Warbinek, 2011, Blood.

MITF is a critical regulator of the carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) in malignant melanoma

D. Schadendorf, I. Helfrich, F. Breitenbuecher, 2015, Pigment cell & melanoma research.

regulatory T cells impairs mouse melanoma growth

D. Schadendorf, J. Buer, I. Helfrich, 2012 .

Primary tumor versus metastasis: new experimental models for studies on cancer cell homing and metastasis in melanoma

D. Schadendorf, I. Helfrich, P. Zigrino, 2014, Pigment cell & melanoma research.

Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma

D. Schadendorf, H. Augustin, I. Helfrich, 2010, Journal of Experimental Medicine.

SIRT1‐mediated deacetylation of FOXO3a transcription factor supports pro‐angiogenic activity of interferon‐deficient tumor‐associated neutrophils

D. Schadendorf, I. Helfrich, K. Lang, 2021, International journal of cancer.

Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma

D. Schadendorf, J. Marine, F. Rambow, 2023, Journal for ImmunoTherapy of Cancer.

Patient-Derived Human Basal and Cutaneous Squamous Cell Carcinoma Tissues Display Apoptosis and Immunomodulation following Gas Plasma Exposure with a Certified Argon Jet

F. Saadati, I. Helfrich, S. Emmert, 2021, International journal of molecular sciences.

CEACAM1-4L Promotes Anchorage-Independent Growth in Melanoma

D. Schadendorf, I. Helfrich, B. Giebel, 2015, Front. Oncol..

Clinical application of noninvasive and nonradioactive determination of microscopic lymph node tumor status by multispectral optoacoustic imaging

Dirk Schadendorf, Stefan Morscher, Neal C. Burton, 2015 .

Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma

J. Utikal, D. Schadendorf, W. Sondermann, 2023, Nature Cancer.

Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization.

D. Schadendorf, H. Augustin, I. Helfrich, 2023, Cancer research.

Allosteric Activation of GDP-Bound Ras Isoforms by Bisphenol Derivative Plasticisers

C. Herrmann, I. Helfrich, H. Bachmann, 2018, International Journal of Molecular Sciences.

Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis.

K. Alitalo, J. Fischer, I. Helfrich, 2012, Blood.

Rapid and fully automated blood vasculature analysis in 3D light-sheet image volumes of different organs

A. Mosig, M. Gunzer, I. Helfrich, 2022, bioRxiv.

Vascular Endothelial Growth Factor Promotes Pericyte Coverage of Brain Capillaries, Improves Cerebral Blood Flow During Subsequent Focal Cerebral Ischemia, and Preserves the Metabolic Penumbra

A. Zechariah, G. Mies, D. Hermann, 2013, Stroke.