H. Kikkawa

发表

Development of lung eosinophilic inflammation by the infusion of IL-5-producing T cell clones.

O. Kaminuma, A. Mori, M. Suko, 1997, International archives of allergy and immunology.

Interaction with Monocytes Enhances IL-5 Gene Transcription in Peripheral T Cells of Asthmatic Patients

O. Kaminuma, A. Mori, H. Kikkawa, 2003, International Archives of Allergy and Immunology.

Transcriptional regulation of the IL‐5 gene in peripheral T cells of asthmatic patients

O. Kaminuma, A. Mori, H. Kikkawa, 2002, Clinical and experimental immunology.

IL-5 Synthesis by T Cells of Allergic Subjects Is Regulated at the Transcriptional Level

O. Kaminuma, A. Mori, H. Kikkawa, 2000, International Archives of Allergy and Immunology.

Differential contribution of two serine residues of wild type and constitutively active β2‐adrenoceptors to the interaction with β2‐selective agonists

H. Kikkawa, T. Nagao, H. Kurose, 1997, British journal of pharmacology.

Angiotensin-converting enzyme inhibitors can potentiate ozone-induced airway hyperresponsiveness.

O. Kaminuma, H. Kikkawa, K. Ikezawa, 1997, European journal of pharmacology.

Inhibition of activin receptor-like kinase 5 attenuates bleomycin-induced pulmonary fibrosis.

H. Kikkawa, S. Asano, H. Higashiyama, 2007, Experimental and molecular pathology.

Tracheal relaxing effects and beta 2-selectivity of TA-2005, a newly developed bronchodilating agent, in isolated guinea pig tissues.

H. Kikkawa, K. Naito, K. Naito, 1991, Japanese journal of pharmacology.

TA-2005, a novel, long-acting, and selective beta 2-adrenoceptor agonist: characterization of its in vivo bronchodilating action in guinea pigs and cats in comparison with other beta 2-agonists.

H. Kikkawa, K. Ikezawa, K. Kanno, 1994, Biological & pharmaceutical bulletin.

Cloned Th Cells Confer Eosinophilic Inflammation and Bronchial Hyperresponsiveness

O. Kaminuma, A. Mori, H. Kikkawa, 1999, International Archives of Allergy and Immunology.

Primary Role of CD4+ T Cells and Supplemental Role of Mast Cells in Allergic Pulmonary Eosinophilia

O. Kaminuma, A. Mori, M. Suko, 1999, International Archives of Allergy and Immunology.

Transient contribution of mast cells to pulmonary eosinophilia but not to hyper‐responsiveness

R. Egan, O. Kaminuma, A. Mori, 2002, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Evidence that cyclosporin A and dexamethasone inhibit allergic airway eosinophilic inflammation via suppression of interleukin‐5 synthesis by T cells

O. Kaminuma, A. Mori, M. Suko, 1998, British journal of pharmacology.

Difference in inhibitory effects of dexamethasone and cyclosporin A on Sephadex bead-induced airway hyperresponsiveness and inflammation in rats.

H. Kikkawa, K. Naito, K. Ikezawa, 1998, Japanese journal of pharmacology.

Successful transfer of late phase eosinophil infiltration in the lung by infusion of helper T cell clones.

O. Kaminuma, A. Mori, M. Suko, 1997, American journal of respiratory cell and molecular biology.

Receptor-activated Smad localisation in Bleomycin-induced pulmonary fibrosis

H. Kikkawa, S. Asano, H. Higashiyama, 2006, Journal of Clinical Pathology.

IL-5-Producing T Cells that Induce Airway Eosinophilia and Hyperresponsiveness Are Suppressed by Dexamethasone and Cyclosporin A in Mice

O. Kaminuma, A. Mori, M. Suko, 1998, International Archives of Allergy and Immunology.

Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors

T. Sasaki, J. Kotera, K. Omori, 2002, Clinical and experimental immunology.

Cyclic AMP suppresses interleukin‐5 synthesis by human helper T cells via the downregulation of the calcium mobilization pathway

O. Kaminuma, A. Mori, H. Kikkawa, 1999, British journal of pharmacology.

Two differential effects of cyclic adenosine 3',5'-monophosphate on IL-5 production by antigen-specific human T cell line.

O. Kaminuma, A. Mori, M. Suko, 1997, The Journal of pharmacology and experimental therapeutics.

Antigen-Induced Airway Migration of a T Helper 2 Clone

O. Kaminuma, A. Mori, H. Kikkawa, 2001, International Archives of Allergy and Immunology.

T cells are involved in the development of arthritis induced by anti-type II collagen antibody.

Keizo Yamashita, H. Kikkawa, Taeko Yonekawa, 2007, International immunopharmacology.

Dynamics of antigen‐specific helper T cells at the initiation of airway eosinophilic inflammation

O. Kaminuma, A. Mori, H. Kikkawa, 2001, European journal of immunology.

H. Kikkawa, K. Naito, M. Kikuchi, 1997, Inflammation Research.

Importance of impairment of the airway epithelium for ozone-induced airway hyperresponsiveness in guinea pigs.

O. Kaminuma, H. Kikkawa, K. Ikezawa, 1995, Japanese journal of pharmacology.

Inhibition of Pulmonary Eosinophilia Does Not Necessarily Prevent the Airway Hyperresponsiveness Induced by Sephadex Beads

H. Kikkawa, K. Naito, K. Ogawa, 1998, International Archives of Allergy and Immunology.

Prevention of ozone-induced airway hyperresponsiveness and epithelial injury by phosphodiesterase inhibitors in guinea pigs.

O. Kaminuma, H. Kikkawa, K. Naito, 1997, Environmental toxicology and pharmacology.

Humoral Immunity Is Dispensable for the Local Recruitment of Antigen-Specific Th2 Cells

O. Kaminuma, A. Mori, H. Kikkawa, 2001, International Archives of Allergy and Immunology.

Effects of Alendronate and Prednisolone on a Model of Rheumatoid Arthritis in Mice

H. Kikkawa, S. Asano, Taeko Yonekawa, 2007 .

A selective type 4 phosphodiesterase inhibitor, T-440, modulates intracellular cyclic AMP level and interleukin-2 production of Jurkat cells.

O. Kaminuma, A. Mori, M. Suko, 1998, Immunopharmacology.

Inhibitory effect of a novel phosphodiesterase IV inhibitor, T-440, on antigen- and chemical mediator-induced bronchoconstrictions in guinea pigs in vivo.

O. Kaminuma, H. Kikkawa, K. Ikezawa, 1996, Japanese journal of pharmacology.

Synthesis and biological activities of 1-pyridylisoquinoline and 1-pyridyldihydroisoquinoline derivatives as PDE4 inhibitors.

T. Ukita, H. Kikkawa, K. Naito, 2003, Bioorganic & medicinal chemistry letters.

Novel, potent, and selective phosphodiesterase-4 inhibitors as antiasthmatic agents: synthesis and biological activities of a series of 1-pyridylnaphthalene derivatives.

T. Ukita, H. Kikkawa, K. Naito, 1999, Journal of medicinal chemistry.

Novel selective PDE IV inhibitors as antiasthmatic agents. Synthesis and biological activities of a series of 1-aryl-2,3-bis(hydroxymethyl)naphthalene lignans.

O. Kaminuma, H. Kikkawa, Y. Moritani, 1996, Journal of medicinal chemistry.

Changes in micro-CT 3D bone parameters reflect effects of a potent cathepsin K inhibitor (SB-553484) on bone resorption and cortical bone formation in ovariectomized mice.

H. Kikkawa, S. Asano, Sanjay Kumar, 2007, Bone.

From Molecular Science to the Treatment of Allergy

M. Manns, Jane Wilkinson, P. Hufnagl, 1999, International Archives of Allergy and Immunology.

Inverse relationship between Sec14l3 mRNA/protein expression and allergic airway inflammation.

Keizo Yamashita, H. Kikkawa, S. Asano, 2009, European journal of pharmacology.

The role of the seventh transmembrane region in high affinity binding of a beta 2-selective agonist TA-2005.

H. Kikkawa, T. Nagao, H. Kurose, 1998, Molecular pharmacology.

Correlation between eosinophilia induced by CD4(+) T cells and bronchial hyper-responsiveness.

R. Egan, O. Kaminuma, A. Mori, 2001, International immunology.

Analysis of Change Patterns of Microcomputed Tomography 3-Dimensional Bone Parameters as a High-Throughput Tool to Evaluate Antiosteoporotic Effects of Agents at an Early Stage of Ovariectomy-Induced Osteoporosis in Mice

H. Kikkawa, S. Asano, A. Xiang, 2006, Investigative radiology.

Late airway obstruction and neutrophil infiltration in sensitized mice after antigen provocation were suppressed by selective and non-selective phosphodiesterase inhibitors

O. Kaminuma, M. Suko, H. Kikkawa, 1997 .

Inhibition of Phosphodiesterase Type 4 Decreases Stress-Induced Defecation in Rats and Mice

Hideo Kikkawa, F. Barone, H. Kikkawa, 2007, Pharmacology.

Binding pockets of the beta(1)- and beta(2)-adrenergic receptors for subtype-selective agonists.

H. Kikkawa, T. Nagao, H. Kurose, 1999, Molecular pharmacology.

Domains of beta1 and beta2 adrenergic receptors to bind subtype selective agonists.

H. Kikkawa, T. Nagao, H. Kurose, 1998, Life sciences.