M. Wajner

M. Wajner, A. Wyse, C. Dutra-filho, 2001, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

2‐Methylcitric acid impairs glutamate metabolism and induces permeability transition in brain mitochondria

M. Wajner, A. U. Amaral, R. F. Castilho, 2016, Journal of neurochemistry.

L-carnitine supplementation as a potential antioxidant therapy for inherited neurometabolic disorders.

C. Vargas, M. Wajner, G. Ribas, 2014, Gene.

Maple syrup urine disease in treated patients: biochemical and oxidative stress profiles.

A. Sitta, C. Vargas, M. Wajner, 2008, Clinical biochemistry.

Mitochondrial Dysfunction and Redox Homeostasis Impairment as Pathomechanisms of Brain Damage in Ethylmalonic Encephalopathy: Insights from Animal and Human Studies

G. Leipnitz, M. Wajner, M. Grings, 2020, Cellular and Molecular Neurobiology.

Relationship between serum immunoglobulin G and alpha-fetoprotein levels during human pregnancy

M. Wajner, S. Papiha, T. I. Wagstaff, 1987, Journal of perinatal medicine.

Disturbance of mitochondrial functions associated with permeability transition pore opening induced by cis-5-tetradecenoic and myristic acids in liver of adolescent rats.

M. Wajner, A. U. Amaral, S. Wajner, 2019, Mitochondrion.

Metabolite accumulation in VLCAD deficiency markedly disrupts mitochondrial bioenergetics and Ca2+ homeostasis in the heart

M. Wajner, A. U. Amaral, S. Wajner, 2018, The FEBS journal.

Disturbance of mitochondrial functions provoked by the major long-chain 3-hydroxylated fatty acids accumulating in MTP and LCHAD deficiencies in skeletal muscle.

M. Wajner, A. U. Amaral, Janaina da Silva, 2016, Toxicology in vitro : an international journal published in association with BIBRA.

mitochondrial permeability transition pore opening in rat brain and liver : possible implications for the pathogenesis of MCAD deficiency

M. Wajner, A. U. Amaral, R. Ribeiro, 2016 .

3-Hydroxy-3-methylglutaric and 3-methylglutaric acids impair redox status and energy production and transfer in rat heart: relevance for the pathophysiology of cardiac dysfunction in 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency

G. Leipnitz, M. Wajner, B. Seminotti, 2016, Free radical research.

Disruption of redox homeostasis in cerebral cortex of developing rats by acylcarnitines accumulating in medium-chain acyl-CoA dehydrogenase deficiency

G. Leipnitz, M. Wajner, M. Grings, 2012, International Journal of Developmental Neuroscience.

Evidence that l-Carnitine and Selenium Supplementation Reduces Oxidative Stress in Phenylketonuric Patients

A. Sitta, C. Vargas, M. Wajner, 2011, Cellular and Molecular Neurobiology.

Neurochemical evidence that phytanic acid induces oxidative damage and reduces the antioxidant defenses in cerebellum and cerebral cortex of rats.

G. Leipnitz, C. Vargas, M. Wajner, 2010, Life sciences.

D-Serine induces lipid and protein oxidative damage and decreases glutathione levels in brain cortex of rats

G. Leipnitz, M. Wajner, C. Fernandes, 2009, Brain Research.

Induction of oxidative stress by the metabolites accumulating in isovaleric acidemia in brain cortex of young rats

G. Leipnitz, M. Wajner, C. Fernandes, 2008, Free radical research.

Early effects of LPS-induced neuroinflammation on the rat hippocampal glycolytic pathway

M. Wajner, C. Gonçalves, L. Bobermin, 2022, Journal of Neuroinflammation.

Evidence that 3-hydroxyglutaric acid interacts with NMDA receptors in synaptic plasma membranes from cerebral cortex of young rats

D. Souza, M. Wajner, C. Ribeiro, 2004, Neurochemistry International.

Reduction of large neutral amino acid concentrations in plasma and CSF of patients with maple syrup urine disease during crises

C. Vargas, M. Wajner, R. Pires, 2000, Journal of Inherited Metabolic Disease.

Reduction of large neutral amino acid levels in plasma and brain of hyperleucinemic rats

C. Vargas, M. Wajner, A. Wyse, 2001, Neurochemistry International.

α-Keto Acids Accumulating in Maple Syrup Urine Disease Stimulate Lipid Peroxidation and Reduce Antioxidant Defences in Cerebral Cortex From Young Rats

M. Wajner, C. Dutra-filho, C. Wannmacher, 2005, Metabolic Brain Disease.

Disruption of oxidative phosphorylation and synaptic Na(+), K(+)-ATPase activity by pristanic acid in cerebellum of young rats.

M. Wajner, C. Ribeiro, Â. Zanatta, 2014, Life sciences.

Marked inhibition of Na+, K+ - ATPase activity and the respiratory chain by phytanic acid in cerebellum from young rats: possible underlying mechanisms of cerebellar ataxia in Refsum disease

G. Leipnitz, C. Vargas, M. Wajner, 2013, Journal of Bioenergetics and Biomembranes.

Neurochemical Evidence that Pristanic Acid Impairs Energy Production and Inhibits Synaptic Na+, K+-ATPase Activity in Brain of Young Rats

M. Wajner, M. Grings, C. Viegas, 2011, Neurochemical Research.

Isovaleric Acid Reduces Na+, K+-ATPase Activity in Synaptic Membranes from Cerebral Cortex of Young Rats

M. Wajner, C. Ribeiro, Vanessa Grando, 2007, Cellular and Molecular Neurobiology.

Synaptic Plasma Membrane Na+, K+-ATPase Activity is Significantly Reduced by the α-Keto Acids Accumulating in Maple Syrup Urine Disease in Rat Cerebral Cortex

M. Wajner, C. Dutra-filho, C. Wannmacher, 2007, Metabolic Brain Disease.

Proline Administration Decreases Na+,K+-ATPase Activity in the Synaptic Plasma Membrane from Cerebral Cortex of Rats

M. Wajner, A. Wyse, C. Dutra-filho, 1999, Metabolic Brain Disease.

Distribution of xanthine dehydrogenase and oxidase activities in human and rabbit tissues.

M. Wajner, R. A. Harkness, 1989, Biochimica et biophysica acta.

Prevention by L-carnitine of DNA damage induced by 3-hydroxy-3-methylglutaric and 3-methylglutaric acids and experimental evidence of lipid and DNA damage in patients with 3-hydroxy-3-methylglutaric aciduria.

A. Sitta, C. Vargas, M. Wajner, 2019, Archives of biochemistry and biophysics.

Prevention by L-carnitine of DNA damage induced by propionic and L-methylmalonic acids in human peripheral leukocytes in vitro.

C. Vargas, M. Wajner, G. Ribas, 2010, Mutation research.

Evidence that DNA damage is associated to phenylalanine blood levels in leukocytes from phenylketonuric patients.

A. Sitta, C. Vargas, M. Wajner, 2009, Mutation research.

Mitochondrial energy metabolism in neurodegeneration associated with methylmalonic acidemia

M. Wajner, A. Kowaltowski, R. F. Castilho, 2011, Journal of bioenergetics and biomembranes.

The effect of WIN 55,212-2 suggests a cannabinoid-sensitive component in the early toxicity induced by organic acids accumulating in glutaric acidemia type I and in related disorders of propionate metabolism in rat brain synaptosomes

D. Souza, G. Leipnitz, M. Wajner, 2015, Neuroscience.

Cannabinoid receptor agonists reduce the short-term mitochondrial dysfunction and oxidative stress linked to excitotoxicity in the rat brain

M. Wajner, A. Santamaría, E. Pinzón, 2015, Neuroscience.

Alanine Prevents the Reduction of Pyruvate Kinase Activity in Brain Cortex of Rats Subjected to Chemically Induced Hyperphenylalaninemia

M. Wajner, A. Wyse, V. Rech, 2002, Neurochemical Research.

Effect of hypoxanthine on Na+,K+-ATPase activity and some parameters of oxidative stress in rat striatum

M. Wajner, C. Matté, A. Wyse, 2005, Brain Research.

Alpha-Ketoisocaproic Acid Increases Phosphorylation of Intermediate Filament Proteins from Rat Cerebral Cortex by Mechanisms Involving Ca2+ and cAMP

M. Wajner, S. Loureiro, A. Zamoner, 2005, Neurochemical Research.

Experimental Evidence that 3-Methylglutaric Acid Disturbs Mitochondrial Function and Induced Oxidative Stress in Rat Brain Synaptosomes: New Converging Mechanisms

D. Souza, G. Leipnitz, M. Wajner, 2016, Neurochemical Research.

Striatum is more vulnerable to oxidative damage induced by the metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency as compared to liver

G. Leipnitz, C. Vargas, M. Wajner, 2009, International Journal of Developmental Neuroscience.

NMDA Receptors and Oxidative Stress Induced by the Major Metabolites Accumulating in HMG Lyase Deficiency Mediate Hypophosphorylation of Cytoskeletal Proteins in Brain From Adolescent Rats: Potential Mechanisms Contributing to the Neuropathology of This Disease

M. Wajner, C. Fernandes, Paula Pierozan, 2015, Neurotoxicity Research.

Reduction of Na+, K+-ATPase activity and expression in cerebral cortex of glutaryl-CoA dehydrogenase deficient mice: a possible mechanism for brain injury in glutaric aciduria type I.

M. Wajner, C. Fernandes, B. Seminotti, 2012, Molecular genetics and metabolism.

Marked reduction of Na(+), K(+)-ATPase and creatine kinase activities induced by acute lysine administration in glutaryl-CoA dehydrogenase deficient mice.

M. Wajner, C. Fernandes, B. Seminotti, 2012, Molecular genetics and metabolism.

Inhibition of creatine kinase activity by lysine in rat cerebral cortex

G. Leipnitz, M. Wajner, B. Seminotti, 2009, Metabolic Brain Disease.

Energy Metabolism is Compromised in Skeletal Muscle of Rats Chronically-Treated with Glutaric Acid

C. Vargas, M. Wajner, A. Wyse, 2007, Metabolic Brain Disease.

Inhibition of the Electron Transport Chain and Creatine Kinase Activity by Ethylmalonic Acid in Human Skeletal Muscle

C. Vargas, M. Wajner, A. Wyse, 2006, Metabolic Brain Disease.

Glutaric Acid Administration Impairs Energy Metabolism in Midbrain and Skeletal Muscle of Young Rats

C. Vargas, M. Wajner, C. Ribeiro, 2005, Neurochemical Research.

L-Pyroglutamic Acid Inhibits Energy Production and Lipid Synthesis in Cerebral Cortex of Young Rats In Vitro

M. Wajner, C. Ruschel, A. Wyse, 2001, Neurochemical Research.

Tryptophan reduces creatine kinase activity in the brain cortex of rats

M. Wajner, A. Wyse, C. Dutra-filho, 2004, International Journal of Developmental Neuroscience.

l-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase activity from cerebellum of developing rats

G. Leipnitz, M. Wajner, C. Ribeiro, 2003, International Journal of Developmental Neuroscience.

Inhibition of Creatine Kinase Activity by Cystine in the Kidney of Young Rats

V. Rodrigues-Junior, M. Wajner, A. Wyse, 2006, Pediatric Research.

The effects of the interactions between amino acids on pyruvate kinase activity from the brain cortex of young rats

M. Wajner, A. Wyse, L. Feksa, 2005, International Journal of Developmental Neuroscience.

Cysteamine prevents and reverses the inhibition of pyruvate kinase activity caused by cystine in rat heart.

M. Wajner, C. Wannmacher, Angela Terezinha de Souza Wyse, 2004, Biochimica et biophysica acta.

Inhibition of pyruvate kinase activity by cystine in brain cortex of rats

M. Wajner, A. Wyse, L. Feksa, 2004, Brain Research.

Homocysteine Inhibits Butyrylcholinesterase Activity in Rat Serum

M. Wajner, A. Wyse, F. Stefanello, 2003, Metabolic Brain Disease.

Kinetic studies on the inhibition of creatine kinase activity by branched-chain α-amino acids in the brain cortex of rats

M. Wajner, A. Wyse, C. Dutra-filho, 2003, International Journal of Developmental Neuroscience.

l-Carnitine Blood Levels and Oxidative Stress in Treated Phenylketonuric Patients

A. Sitta, C. Vargas, M. Wajner, 2009, Cellular and Molecular Neurobiology.

Platelet Na+,K+-ATPase activity as a possible peripheral marker for the neurotoxic effects of phenylalanine in phenylketonuria

M. Wajner, A. Wyse, C. Dutra-filho, 2000, Metabolic Brain Disease.

Reduced Na+,K+-ATPase Activity in Erythrocyte Membranes from Patients with Phenylketonuria

M. Wajner, A. Wyse, C. Dutra-filho, 2001, Pediatric Research.

Stimulation of Lipid Peroxidation in Vitro in Rat Brain by the Metabolites Accumulating in Maple Syrup Urine Disease

M. Wajner, C. Dutra-filho, C. Wannmacher, 2002, Metabolic Brain Disease.

Propionic and L‐methylmalonic acids induce oxidative stress in brain of young rats

M. Wajner, C. Dutra-filho, C. Wannmacher, 2000, Neuroreport.

Pathophysiology of maple syrup urine disease: Focus on the neurotoxic role of the accumulated branched-chain amino acids and branched-chain α-keto acids

M. Wajner, A. U. Amaral, 2022, Neurochemistry International.

Anandamide Reduces the Toxic Synergism Exerted by Quinolinic Acid and Glutaric Acid in Rat Brain Neuronal Cells

M. Wajner, J. Pedraza-Chaverri, A. Santamaría, 2019, Neuroscience.

Glycine Provokes Lipid Oxidative Damage and Reduces the Antioxidant Defenses in Brain Cortex of Young Rats

G. Leipnitz, M. Wajner, C. Fernandes, 2009, Cellular and Molecular Neurobiology.

Long-chain 3-hydroxy fatty acids accumulating in long-chain 3-hydroxyacyl-CoA dehydrogenase and mitochondrial trifunctional protein deficiencies uncouple oxidative phosphorylation in heart mitochondria

M. Wajner, A. U. Amaral, M. Grings, 2013, Journal of Bioenergetics and Biomembranes.

Disturbance of mitochondrial energy homeostasis caused by the metabolites accumulating in LCHAD and MTP deficiencies in rat brain.

M. Wajner, A. U. Amaral, M. Grings, 2010, Life sciences.

Methylmalonic acid induces inflammatory response and redox homeostasis disruption in C6 astroglial cells: potential glioprotective roles of melatonin and resveratrol

G. Leipnitz, M. Wajner, C. Gonçalves, 2022, Amino Acids.

Inhibition of Na+, K+-ATPase Activity by the Metabolites Accumulating in Homocystinuria

M. Wajner, A. Wyse, C. Wannmacher, 2002, Metabolic Brain Disease.

Oxidative stress is induced in female carriers of X-linked adrenoleukodystrophy

A. Sitta, C. Vargas, M. Wajner, 2008, Journal of the Neurological Sciences.

Methylmalonate inhibits succinate-supported oxygen consumption by interfering with mitochondrial succinate uptake

M. Wajner, G. C. Ferreira, R. F. Castilho, 2008, Journal of Inherited Metabolic Disease.

In Vitro Homocysteine Inhibits Platelet Na+, K+-ATPase and Serum Butyrylcholinesterase Activities of Young Rats

M. Wajner, A. Wyse, F. Stefanello, 2003, Metabolic Brain Disease.

Alanine Prevents the Decrease of Na+,K+-ATPase Activity in Experimental Phenylketonuria

M. Wajner, A. Wyse, C. Wannmacher, 1999, Metabolic Brain Disease.

Inhibition of Na+,K+-ATPase Activity from Rat Hippocampus by Proline

M. Wajner, Angela Terezinha de Souza Wyse, R. Franzon, 2001, Neurochemical Research.

KINETICS OF ALANINE REVERSAL ON THE INHIBITION OF NA+, K+-ATPASE ACTIVITY BY PHENYLALANINE AND PHENYLLACTATE IN THE SYNAPTIC PLASMA MEMBRANE FROM THE CEREBRAL CORTEX OF RATS

M. Wajner, C. Wannmacher, A. Wyse, 1998 .

Alanine reverses the inhibitory effect of phenylalanine and its metabolites on Na+,K(+)-ATPase in synaptic plasma membranes from cerebral cortex of rats.

M. Wajner, C. Wannmacher, A. Wyse, 1995, Biochemical Society transactions.

Diminished concentrations of ganglioside N-acetylneuraminic acid (G-NeuAc) in cerebellum of young rats receiving chronic administration of methylmalonic acid

M. Wajner, C. Wannmacher, R. Pires, 1988, Journal of the Neurological Sciences.

Hyperphenylalaninemia reduces creatine kinase activity in the cerebral cortex of rats

M. Wajner, A. Wyse, C. Dutra-filho, 2003, International Journal of Developmental Neuroscience.

Effects of 1,4-butanediol administration on oxidative stress in rat brain: Study of the neurotoxicity of γ-hydroxybutyric acid in vivo

M. Wajner, A. Wyse, C. Dutra-filho, 2009, Metabolic Brain Disease.

Disruption of mitochondrial bioenergetics, calcium retention capacity and cell viability caused by D-2-hydroxyglutaric acid in the heart.

M. Wajner, A. U. Amaral, S. Wajner, 2022, Biochimie.

Deregulation of mitochondrial functions provoked by long‐chain fatty acid accumulating in long‐chain 3‐hydroxyacyl‐CoA dehydrogenase and mitochondrial permeability transition deficiencies in rat heart – mitochondrial permeability transition pore opening as a potential contributing pathomechanism of

M. Wajner, A. U. Amaral, C. Cecatto, 2015, The FEBS journal.

α-Ketoisocaproic acid and leucine provoke mitochondrial bioenergetic dysfunction in rat brain

G. Leipnitz, M. Wajner, C. Fernandes, 2010, Brain Research.

Induction of oxidative stress in rat brain by the metabolites accumulating in maple syrup urine disease

M. Wajner, C. Dutra-filho, R. Bridi, 2003, International Journal of Developmental Neuroscience.

Inhibition of mitogen-activated proliferation of human peripheral lymphocytes in vitro by propionic acid.

M. Wajner, C. Wannmacher, M. Rocha, 1999, Clinical science.

Effects of acute and chronic administration of methylmalonic and propionic acids on the in vitro incorporation of 32P into cytoskeletal proteins from cerebral cortex of young rats

M. Wajner, R. Pessoa-Pureur, M. Freitas, 1998, Neurochemistry International.

Disturbance of the glutamatergic system by glutaric acid in striatum and cerebral cortex of glutaryl-CoA dehydrogenase-deficient knockout mice: Possible implications for the neuropathology of glutaric acidemia type I

D. Souza, M. Wajner, C. Fernandes, 2014, Journal of the Neurological Sciences.

Neurochemical effects ofl-pyroglutamic acid

D. Souza, M. Wajner, C. F. Mello, 1995, Neurochemical Research.

Pharmacological evidence that α-ketoisovaleric acid induces convulsions through GABAergic and glutamatergic mechanisms in rats

M. Wajner, A. Coitinho, M. R. Fighera, 2001, Brain Research.

Quinolinic acid inhibits glutamate uptake into synaptic vesicles from rat brain

D. Souza, M. Wajner, R. Tavares, 2000, Neuroreport.

Pharmacological evidence for GABAergic and glutamatergic involvement in the convulsant and behavioral effects of glutaric acid

M. Wajner, C. F. Mello, A. Jurach, 1998, Brain Research.

Neurochemical Evidence that Lysine Inhibits Synaptic Na+,K+-ATPase Activity and Provokes Oxidative Damage in Striatum of Young Rats In vivo

G. Leipnitz, M. Wajner, C. Fernandes, 2011, Neurochemical Research.

Inhibition of Na+,K+-ATPase Activity in Hippocampus of Rats Subjected to Acute Administration of Homocysteine Is Prevented by Vitamins E and C Treatment

M. Wajner, C. Matté, A. Wyse, 2002, Neurochemical Research.

Inhibition of Rat Brain Na+, K+-ATPase Activity Induced by Homocysteine Is Probably Mediated by Oxidative Stress

M. Wajner, A. Wyse, C. Wannmacher, 2001, Neurochemical Research.

Toxic synergism between quinolinic acid and organic acids accumulating in glutaric acidemia type I and in disorders of propionate metabolism in rat brain synaptosomes: Relevance for metabolic acidemias

D. Souza, G. Leipnitz, M. Wajner, 2015, Neuroscience.

Induction of oxidative stress by the metabolites accumulating in 3-methylglutaconic aciduria in cerebral cortex of young rats.

G. Leipnitz, M. Wajner, B. Seminotti, 2008, Life sciences.

Evidence that 3‐hydroxy‐3‐methylglutaric acid promotes lipid and protein oxidative damage and reduces the nonenzymatic antioxidant defenses in rat cerebral cortex

G. Leipnitz, M. Wajner, B. Seminotti, 2008, Journal of neuroscience research.

Signaling mechanisms underlying the glioprotective effects of resveratrol against mitochondrial dysfunction.

D. Souza, M. Wajner, C. Gonçalves, 2016, Biochimica et biophysica acta.

D‐2‐Hydroxyglutaric acid inhibits creatine kinase activity from cardiac and skeletal muscle of young rats

G. Leipnitz, M. Wajner, C. Ribeiro, 2003, European journal of clinical investigation.

Evaluation of the mechanisms involved in leucine-induced oxidative damage in cerebral cortex of young rats

M. Wajner, C. Dutra-filho, A. Latini, 2005, Free radical research.

Induction of Neuroinflammatory Response and Histopathological Alterations Caused by Quinolinic Acid Administration in the Striatum of Glutaryl-CoA Dehydrogenase Deficient Mice

D. Souza, G. Leipnitz, C. Vargas, 2017, Neurotoxicity Research.

3-Hydroxyglutaric acid enhances glutamate uptake into astrocytes from cerebral cortex of young rats

D. Souza, M. Wajner, C. Ribeiro, 2004, Neurochemistry International.

L-2-Hydroxyglutaric aciduria: pattern of MR imaging abnormalities in 56 patients.

D. Zafeiriou, G. Uziel, M. Wajner, 2009, Radiology.

Lipid, Oxidative and Inflammatory Profile and Alterations in the Enzymes Paraoxonase and Butyrylcholinesterase in Plasma of Patients with Homocystinuria Due CBS Deficiency: The Vitamin B12 and Folic Acid Importance

C. Vargas, M. Wajner, L. Vilarinho, 2015, Cellular and Molecular Neurobiology.

Cytoskeleton as a potential target in the neuropathology of maple syrup urine disease: Insight from animal studies

M. Wajner, R. Pessoa-Pureur, 2007, Journal of Inherited Metabolic Disease.

alpha-Ketoisocaproic acid regulates phosphorylation of intermediate filaments in postnatal rat cortical slices through ionotropic glutamatergic receptors.

M. Wajner, S. Loureiro, C. Funchal, 2002, Brain research. Developmental brain research.

α-Keto-β-methylvaleric acid increases the in vitro phosphorylation of intermediate filaments in cerebral cortex of young rats through the gabaergic system

M. Wajner, S. Loureiro, R. Pessoa-Pureur, 2004, Journal of the Neurological Sciences.

Neurochemical evidence that glycine induces bioenergetical dysfunction

M. Wajner, E. B. Busanello, G. C. Ferreira, 2010, Neurochemistry International.

A chemically-induced acute model of maple syrup urine disease in rats for neurochemical studies

C. Vargas, M. Wajner, C. Dutra-filho, 2006, Journal of Neuroscience Methods.

Branched-Chain α-Keto Acids Accumulating in Maple Syrup Urine Disease Induce Reorganization of Phosphorylated GFAP in C6-Glioma Cells

M. Wajner, C. Gottfried, A. Zamoner, 2005, Metabolic Brain Disease.

Morphological Alterations and Cell Death Provoked by the Branched-Chain α-Amino Acids Accumulating in Maple Syrup Urine Disease in Astrocytes from Rat Cerebral Cortex

M. Wajner, C. Gottfried, R. Pessoa-Pureur, 2005, Cellular and Molecular Neurobiology.

Intrahippocampal administration of the branched-chain α-hydroxy acids accumulating in maple syrup urine disease compromises rat performance in aversive and non-aversive behavioral tasks

M. Wajner, V. Vasques, F. Brinco, 2005, Journal of the Neurological Sciences.

Intrahippocampal administration of the α-keto acids accumulating in maple syrup urine disease provokes learning deficits in rats

M. Wajner, C. F. Mello, M. D. Boer, 2004, Pharmacology Biochemistry and Behavior.

Alpha‐ketoisocaproate increases the in vitro 32P incorporation into intermediate filaments in cerebral cortex of rats

M. Wajner, R. Pessoa-Pureur, T. Branco, 2000, Neuroreport.

Bezafibrate prevents mitochondrial dysfunction, antioxidant system disturbance, glial reactivity and neuronal damage induced by sulfite administration in striatum of rats: Implications for a possible therapeutic strategy for sulfite oxidase deficiency.

G. Leipnitz, M. Wajner, P. M. August, 2017, Biochimica et biophysica acta. Molecular basis of disease.

Sulfite disrupts brain mitochondrial energy homeostasis and induces mitochondrial permeability transition pore opening via thiol group modification.

G. Leipnitz, M. Wajner, A. Wyse, 2014, Biochimica et biophysica acta.

Mitochondrial dysfunction in fatty acid oxidation disorders: insights from human and animal studies

M. Wajner, A. U. Amaral, 2015, Bioscience reports.

cis-4-decenoic acid provokes mitochondrial bioenergetic dysfunction in rat brain.

F. Klamt, M. Wajner, E. B. Tahara, 2010, Life sciences.

Evidence that the major metabolites accumulating in medium-chain acyl-CoA dehydrogenase deficiency disturb mitochondrial energy homeostasis in rat brain

F. Klamt, M. Wajner, G. C. Ferreira, 2009, Brain Research.

Mechanistic Bases of Neurotoxicity Provoked by Fatty Acids Accumulating in MCAD and LCHAD Deficiencies

M. Wajner, A. U. Amaral, C. Cecatto, 2017 .

Increased oxidative stress in patients with 3-hydroxy-3-methylglutaric aciduria

A. Sitta, C. Vargas, M. Wajner, 2015, Molecular and Cellular Biochemistry.

Disruption of redox homeostasis and brain damage caused in vivo by methylmalonic acid and ammonia in cerebral cortex and striatum of developing rats

A. Sitta, G. Leipnitz, M. Wajner, 2014, Free radical research.

Ethylmalonic acid impairs brain mitochondrial succinate and malate transport.

G. Leipnitz, M. Wajner, A. U. Amaral, 2012, Molecular genetics and metabolism.

High urinary excretion of N‐(pyrrole‐2‐carboxyl) glycine in type II hyperprolinemia

M. Wajner, C. Wannmacher, P. Purkiss, 1990, Clinical genetics.

Disruption of mitochondrial functions and oxidative stress contribute to neurologic dysfunction in organic acidurias.

C. Vargas, M. Wajner, A. U. Amaral, 2020, Archives of biochemistry and biophysics.

Pathogenesis of brain damage in glutaric acidemia type I: Lessons from the genetic mice model

G. Leipnitz, M. Wajner, B. Seminotti, 2019, International Journal of Developmental Neuroscience.

Experimental evidence that bioenergetics disruption is not mainly involved in the brain injury of glutaryl-CoA dehydrogenase deficient mice submitted to lysine overload

M. Wajner, B. Seminotti, A. U. Amaral, 2015, Brain Research.

Increased Glutamate Receptor and Transporter Expression in the Cerebral Cortex and Striatum of Gcdh -/- Mice: Possible Implications for the Neuropathology of Glutaric Acidemia Type I

M. Wajner, B. Seminotti, U. Matte, 2014, PloS one.

Oxidative Stress in Patients with X-Linked Adrenoleukodystrophy

C. Vargas, M. Wajner, B. Donida, 2016, Cellular and Molecular Neurobiology.

Antioxidant Effect of Cysteamine in Brain Cortex of Young Rats

M. Wajner, C. Dutra-filho, C. Wannmacher, 2008, Neurochemical Research.

Kynurenines Impair Energy Metabolism in Rat Cerebral Cortex

M. Wajner, C. Dutra-filho, A. Latini, 2007, Cellular and Molecular Neurobiology.

Characterization of the inhibition of pyruvate kinase caused by phenylalanine and phenylpyruvate in rat brain cortex

M. Wajner, A. Wyse, L. Feksa, 2003, Brain Research.

Effect of phenylalanine and its metabolites on ATP diphosphohydrolase activity in synaptosomes from rat cerebral cortex

M. Wajner, M. Schetinger, J. Cunha-Filho, 1994, Neurochemical Research.

Inhibition of Mitochondrial Creatine Kinase Activity by D-2-Hydroxyglutaric Acid in Cerebellum of Young Rats

M. Wajner, A. Wyse, C. Wannmacher, 2003, Neurochemical Research.

Inhibition of mitogen and allogeneic stimulated lymphocyte growth by human amniotic fluid: lack of correlation between alpha-fetoprotein level and in vitro immunosuppression.

M. Wajner, S. Papiha, T. I. Wagstaff, 1986, European journal of obstetrics, gynecology, and reproductive biology.

Neurological Damage in MSUD: The Role of Oxidative Stress

A. Sitta, C. Vargas, M. Wajner, 2014, Cellular and Molecular Neurobiology.

Response of human peripheral blood lymphocytes in the presence of cord sera: relationship of lymphocyte transformation with number of pregnancies and levels of alpha-fetoprotein.

M. Wajner, S. Papiha, T. I. Wagstaff, 1983, Clinical and experimental immunology.

High vulnerability of the heart and liver to 3‐hydroxypalmitic acid–induced disruption of mitochondrial functions in intact cell systems

C. Vargas, M. Wajner, A. U. Amaral, 2018, Journal of cellular biochemistry.

Inhibition of energy metabolism in cerebral cortex of young rats by the medium-chain fatty acids accumulating in MCAD deficiency

M. Wajner, C. Ribeiro, A. Wyse, 2004, Brain Research.

Lysine induces lipid and protein damage and decreases reduced glutathione concentrations in brain of young rats

G. Leipnitz, C. Vargas, M. Wajner, 2008, International Journal of Developmental Neuroscience.

Protective effect of L-carnitine on Phenylalanine-induced DNA damage

C. Vargas, M. Wajner, D. Moura, 2015, Metabolic Brain Disease.

Neurological manifestations of organic acidurias

M. Wajner, 2019, Nature Reviews Neurology.

Propionic Acid Induces Cytoskeletal Alterations in Cultured Astrocytes From Rat Cerebral Cortex

M. Wajner, C. Gottfried, R. Pessoa-Pureur, 2006, Metabolic Brain Disease.

Ascorbic acid prevents cognitive deficits caused by chronic administration of propionic acid to rats in the water maze

M. Wajner, A. Wyse, C. Dutra-filho, 2002, Pharmacology Biochemistry and Behavior.

A. Sitta, G. Leipnitz, C. Vargas, 2015, Cellular and Molecular Neurobiology.

Ethylmalonic acid impairs bioenergetics by disturbing succinate and glutamate oxidation and induces mitochondrial permeability transition pore opening in rat cerebellum

F. Guma, G. Leipnitz, M. Wajner, 2021, Journal of neurochemistry.

Inborn Errors of Metabolism

Roberto Giugliani, M. Wajner, R. Giugliani, 1989 .

Disruption of Mitochondrial Homeostasis by Phytanic Acid in Cerebellum of Young Rats

C. Vargas, M. Wajner, A. U. Amaral, 2013, The Cerebellum.

Experimental evidence that pristanic acid disrupts mitochondrial homeostasis in brain of young rats

C. Vargas, M. Wajner, A. U. Amaral, 2012, Journal of neuroscience research.

Ornithine and Homocitrulline Impair Mitochondrial Function, Decrease Antioxidant Defenses and Induce Cell Death in Menadione-Stressed Rat Cortical Astrocytes: Potential Mechanisms of Neurological Dysfunction in HHH Syndrome

M. Wajner, A. U. Amaral, André Quincozes-Santos, 2016, Neurochemical Research.

The mitochondrial‐targeted reactive species scavenger JP4‐039 prevents sulfite‐induced alterations in antioxidant defenses, energy transfer, and cell death signaling in striatum of rats

P. Wipf, J. Vockley, G. Leipnitz, 2020, Journal of inherited metabolic disease.

Free Radical Scavengers Prevent Argininosuccinic Acid-Induced Oxidative Stress in the Brain of Developing Rats: a New Adjuvant Therapy for Argininosuccinate Lyase Deficiency?

G. Leipnitz, M. Wajner, B. Seminotti, 2019, Molecular Neurobiology.

Disruption of Brain Redox Homeostasis, Microglia Activation and Neuronal Damage Induced by Intracerebroventricular Administration of S-Adenosylmethionine to Developing Rats

G. Leipnitz, M. Wajner, A. Wyse, 2018, Molecular Neurobiology.

Evidence that Thiosulfate Inhibits Creatine Kinase Activity in Rat Striatum via Thiol Group Oxidation

G. Leipnitz, M. Wajner, A. Wyse, 2018, Neurotoxicity Research.

Long Lasting High Lysine Diet Aggravates White Matter Injury in Glutaryl-CoA Dehydrogenase Deficient (Gcdh−/−) Mice

D. Souza, L. Barbeito, G. Leipnitz, 2018, Molecular Neurobiology.

Bezafibrate Prevents Glycine-Induced Increase of Antioxidant Enzyme Activities in Rat Striatum

G. Leipnitz, M. Wajner, M. Grings, 2018, Molecular Neurobiology.

Disruption of Energy Transfer and Redox Status by Sulfite in Hippocampus, Striatum, and Cerebellum of Developing Rats

G. Leipnitz, M. Wajner, A. Wyse, 2017, Neurotoxicity Research.

Clinical and biochemical findings in 7 patients with X-linked adrenoleukodystrophy treated with Lorenzo's Oil

C. Vargas, M. Wajner, R. Giugliani, 2000 .

Evaluation of the mechanism underlying the inhibitory effect of guanidinoacetate on brain Na+, K+-ATPase activity

M. Wajner, A. Wyse, C. Wannmacher, 2004, International Journal of Developmental Neuroscience.

Inhibition of Na+, K+-ATPase activity in rat striatum by guanidinoacetate

M. Wajner, A. Wyse, F. Stefanello, 2003, International Journal of Developmental Neuroscience.

Clinical, biochemical and molecular findings of 24 Brazilian patients with glutaric acidemia type 1: 4 novel mutations in the GCDH gene

A. Sitta, C. Vargas, M. Wajner, 2020, Metabolic Brain Disease.

In vivo intracerebral administration of L-2-hydroxyglutaric acid provokes oxidative stress and histopathological alterations in striatum and cerebellum of adolescent rats.

G. Leipnitz, M. Wajner, B. Seminotti, 2015, Free radical biology & medicine.

Disruption of mitochondrial homeostasis in organic acidurias: insights from human and animal studies

M. Wajner, S. Goodman, 2011, Journal of bioenergetics and biomembranes.

Oxidative stress induction by cis-4-decenoic acid: Relevance for MCAD deficiency

G. Leipnitz, M. Wajner, C. Dutra-filho, 2007, Free radical research.

Inhibition of in vitro CO2 production and lipid synthesis by 2-hydroxybutyric acid in rat brain.

M. Wajner, C. Ruschel, A. Wyse, 2001, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Evidence that the branched‐chain α‐keto acids accumulating in maple syrup urine disease induce morphological alterations and death in cultured astrocytes from rat cerebral cortex

M. Wajner, C. Gottfried, R. Pessoa-Pureur, 2004, Glia.

Evaluation of oxidative damage to biomolecules and inflammation in patients with urea cycle disorders.

M. Wajner, Carmen Regla Vargas, T. Hammerschmidt, 2023, Archives of biochemistry and biophysics.

Citrulline and Ammonia Accumulating in Citrullinemia Reduces Antioxidant Capacity of Rat Brain In Vitro

M. Wajner, A. Wyse, C. Dutra-filho, 2006, Metabolic Brain Disease.

M. Wajner, A. U. Amaral, André Quincozes-Santos, 2016, Neurochemical Research.

Arginine administration reduces catalase activity in midbrain of rats

M. Wajner, A. Wyse, C. Dutra-filho, 2002, Neuroreport.

The influence of amino acids on mitogen-activated proliferation of human lymphocytes in vitro.

M. Wajner, C. Wannmacher, M. B. Fialho, 1994, International journal of immunopharmacology.

Inhibition of the Mitochondrial Respiratory Chain by Phenylalanine in Rat Cerebral Cortex

M. Wajner, A. Wyse, L. Feksa, 2002, Neurochemical Research.

Resveratrol Protects C6 Astrocyte Cell Line against Hydrogen Peroxide-Induced Oxidative Stress through Heme Oxygenase 1

D. Souza, M. Wajner, C. Gottfried, 2013, PloS one.

Inhibition of the mitochondrial respiratory chain complex activities in rat cerebral cortex by methylmalonic acid

M. Wajner, C. Ribeiro, A. Wyse, 2002, Neurochemistry International.

Chronic treatment with glutaric acid induces partial tolerance to excitotoxicity in neuronal cultures from chick embryo telencephalons

M. Wajner, E. Mayatepek, B. Ahlemeyer, 2002, Journal of neuroscience research.

Evidence that quinolinic acid severely impairs energy metabolism through activation of NMDA receptors in striatum from developing rats

M. Wajner, C. Ribeiro, C. Wannmacher, 2006, Journal of neurochemistry.

Oxidative Stress in Homocystinuria Due to Cystathionine ß-Synthase Deficiency: Findings in Patients and in Animal Models

A. Sitta, C. Vargas, M. Wajner, 2017, Cellular and Molecular Neurobiology.

Reduction of Butyrylcholinesterase Activity in Rat Serum Subjected to Hyperhomocysteinemia

M. Wajner, A. Wyse, F. Stefanello, 2005, Metabolic Brain Disease.

Tyrosine administration decreases glutathione and stimulates lipid and protein oxidation in rat cerebral cortex

M. Wajner, A. Wyse, C. Dutra-filho, 2009, Metabolic Brain Disease.

Tyrosine promotes oxidative stress in cerebral cortex of young rats

M. Wajner, A. Wyse, C. Dutra-filho, 2008, International Journal of Developmental Neuroscience.

Clinical findings of patients with hyperammonemia affected by urea cycle disorders with hepatic encephalopathy

A. Sitta, C. Vargas, M. Wajner, 2022, International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.

Alanine Prevents the Inhibition of Pyruvate Kinase Activity Caused by Tryptophan in Cerebral Cortex of Rats

M. Wajner, L. Feksa, C. Dutra-filho, 2003, Metabolic Brain Disease.

Induction of Oxidative Stress by Chronic and Acute Glutaric Acid Administration to Rats

C. Vargas, M. Wajner, C. Dutra-filho, 2007, Cellular and Molecular Neurobiology.

Recent Advances in the Pathophysiology of Fatty Acid Oxidation Defects: Secondary Alterations of Bioenergetics and Mitochondrial Calcium Homeostasis Caused by the Accumulating Fatty Acids

M. Wajner, A. U. Amaral, 2020, Frontiers in Genetics.

Age and Brain Structural Related Effects of Glutaric and 3-Hydroxyglutaric Acids on Glutamate Binding to Plasma Membranes During Rat Brain Development

D. Souza, G. Leipnitz, M. Wajner, 2007, Cellular and Molecular Neurobiology.

Glutaric acid stimulates glutamate binding and astrocytic uptake and inhibits vesicular glutamate uptake in forebrain from young rats

D. Souza, M. Wajner, T. Emanuelli, 2004, Neurochemistry International.

Impairment of GABAergic system contributes to epileptogenesis in glutaric acidemia type I

M. Calcagnotto, M. Wajner, S. Loureiro, 2017, Epilepsia.

An improved specific laboratory test for homocystinuria.

M. Wajner, R. Giugliani, C. Wannmacher, 1982, Clinica chimica acta; international journal of clinical chemistry.

Effect of proline administration on rat behavior in aversive and nonaversive tasks

M. Wajner, C. Wannmacher, J. Moreira, 1989, Pharmacology Biochemistry and Behavior.

Proline Reduces Creatine Kinase Activity in the Brain Cortex of Rats

M. Wajner, C. Dutra-filho, Ângela Terezinha Souza Wyse, 2003, Neurochemical Research.

Effect of Proline on Creatine Kinase Activity in Rat Brain

M. Wajner, A. Wyse, C. Dutra-filho, 2003, Metabolic Brain Disease.

In Vitro Effect of Homocysteine on Some Parameters of Oxidative Stress in Rat Hippocampus

M. Wajner, A. Wyse, C. Dutra-filho, 2003, Metabolic Brain Disease.

Experimental evidence of oxidative stress in plasma of homocystinuric patients: a possible role for homocysteine.

A. Sitta, C. Vargas, M. Wajner, 2011, Molecular genetics and metabolism.

Intracerebroventricular administration of N-acetylaspartic acid impairs antioxidant defenses and promotes protein oxidation in cerebral cortex of rats

M. Wajner, A. Wyse, C. Dutra-filho, 2009, Metabolic Brain Disease.

Effect of Leucine Administration on Creatine Kinase Activity in Rat Brain

M. Wajner, A. Wyse, C. Dutra-filho, 2003, Metabolic Brain Disease.

Chronic early leucine administration induces behavioral deficits in rats.

M. Wajner, L. Feksa, C. Wannmacher, 1999, Life sciences.

Chemically induced model of hypermethioninemia in rats

M. Wajner, C. Matté, A. Wyse, 2007, Journal of Neuroscience Methods.

In vitro evidence that phytanic acid compromises Na+,K+-ATPase activity and the electron flow through the respiratory chain in brain cortex from young rats

C. Vargas, M. Wajner, M. Grings, 2010, Brain Research.

Methionine alters Na+,K+-ATPase activity, lipid peroxidation and nonenzymatic antioxidant defenses in rat hippocampus

M. Wajner, A. Wyse, F. Stefanello, 2005, International Journal of Developmental Neuroscience.

Chronic postnatal ornithine administration to rats provokes learning deficit in the open field task

G. Leipnitz, C. Vargas, M. Wajner, 2012, Metabolic Brain Disease.

Effect of hyperprolinemia on acetylcholinesterase and butyrylcholinesterase activities in rat

M. Wajner, C. Wannmacher, D. Delwing, 2005, Amino Acids.

Proline Reduces Acetylcholinesterase Activity in Cerebral Cortex of Rats

M. Wajner, A. Wyse, C. Wannmacher, 2003, Metabolic Brain Disease.

In vivo and in vitro effects of proline on some parameters of oxidative stress in rat brain

M. Wajner, A. Wyse, C. Dutra-filho, 2003, Brain Research.

Evaluation of the effect of chronic administration of drugs on rat behavior in the water maze task.

M. Wajner, A. Wyse, C. Dutra-filho, 2003, Brain research. Brain research protocols.

Proline induces oxidative stress in cerebral cortex of rats

M. Wajner, A. Wyse, C. Dutra-filho, 2003, International Journal of Developmental Neuroscience.

NA+, K+-ATPASE ACTIVITY IN THE SYNAPTIC PLASMA MEMBRANE FROM THE CEREBRAL CORTEX OF RATS SUBJECTED TO CHEMICALLY INDUCED PHENYLKETONURIA

M. Wajner, C. Wannmacher, A. Wyse, 1995 .

Arginine administration reduces creatine kinase activity in rat cerebellum

M. Wajner, A. Wyse, C. Wannmacher, 2007, Metabolic Brain Disease.

Acute intrastriatal administration of quinolinic acid provokes hyperphosphorylation of cytoskeletal intermediate filament proteins in astrocytes and neurons of rats

T. M. Souza, M. Wajner, S. Loureiro, 2010, Experimental Neurology.

Glycine Administration Alters MAPK Signaling Pathways and Causes Neuronal Damage in Rat Brain: Putative Mechanisms Involved in the Neurological Dysfunction in Nonketotic Hyperglycinemia

G. Leipnitz, M. Wajner, D. Gelain, 2017, Molecular Neurobiology.

Evidence that glycine induces lipid peroxidation and decreases glutathione concentrations in rat cerebellum

G. Leipnitz, M. Wajner, M. Grings, 2014, Molecular and Cellular Biochemistry.

Glycine Intracerebroventricular Administration Disrupts Mitochondrial Energy Homeostasis in Cerebral Cortex and Striatum of Young Rats

G. Leipnitz, M. Wajner, M. Grings, 2013, Neurotoxicity Research.

Monitoring of Phenylalanine Levels in Patients with Phenylketonuria Using Dried Blood Spots: a Comparison of Two Methods

A. Sitta, C. Vargas, M. Wajner, 2020 .

γ-Hydroxybutyric acid induces oxidative stress in cerebral cortex of young rats

M. Wajner, A. Wyse, C. Dutra-filho, 2007, Neurochemistry International.

D‐2‐hydroxyglutaric acid induces oxidative stress in cerebral cortex of young rats

M. Wajner, A. Belló-Klein, C. Dutra-filho, 2003, The European journal of neuroscience.

The molecular landscape of propionic acidemia and methylmalonic aciduria in Latin America

C. Pérez-Cerdá, M. Wajner, B. Merinero, 2010, Journal of Inherited Metabolic Disease.

Protective effects of L-carnitine on behavioral alterations and neuroinflammation in striatum of glutaryl-COA dehydrogenase deficient mice.

A. Sitta, C. Vargas, M. Wajner, 2021, Archives of biochemistry and biophysics.

Disruption of mitochondrial bioenergetics and calcium homeostasis by phytanic acid in the heart: Potential relevance for the cardiomyopathy in Refsum disease.

M. Wajner, A. U. Amaral, S. Wajner, 2023, Biochimica et biophysica acta. Bioenergetics.

3-Methylcrotonylglycine Disrupts Mitochondrial Energy Homeostasis and Inhibits Synaptic Na+,K+-ATPase Activity in Brain of Young Rats

M. Wajner, C. Ribeiro, Â. Zanatta, 2012, Cellular and Molecular Neurobiology.

Acute Liver Failure Induces Glial Reactivity, Oxidative Stress and Impairs Brain Energy Metabolism in Rats

D. Souza, G. Leipnitz, M. Wajner, 2020, Frontiers in Molecular Neuroscience.

Experimental evidence that ornithine and homocitrulline disrupt energy metabolism in brain of young rats

M. Wajner, A. U. Amaral, C. Wannmacher, 2009, Brain Research.

Nitric Oxide Synthase Inhibition by L-NAME Prevents the Decrease of Na+,K+-ATPase Activity in Midbrain of Rats Subjected to Arginine Administration

M. Wajner, C. Dutra-filho, E. Streck, 2001, Neurochemical Research.

Intrastriatal administration of 3-hydroxyglutaric acid induces convulsions and striatal lesions in rats

M. Wajner, E. Mayatepek, B. Ahlemeyer, 2001, Brain Research.

Neurodevelopmental and cognitive behavior of glutaryl-CoA dehydrogenase deficient knockout mice.

M. Wajner, D. Koeller, S. Goodman, 2013, Life sciences.

Evidence that thiol group modification and reactive oxygen species are involved in hydrogen sulfide-induced mitochondrial permeability transition pore opening in rat cerebellum.

G. Leipnitz, M. Wajner, A. U. Amaral, 2019, Mitochondrion.

Bezafibrate In Vivo Administration Prevents 3-Methylglutaric Acid-Induced Impairment of Redox Status, Mitochondrial Biogenesis, and Neural Injury in Brain of Developing Rats

G. Leipnitz, M. Wajner, M. S. da Rosa, 2019, Neurotoxicity Research.

Methylmalonate administration decreases Na+,K+‐ATPase activity in cerebral cortex of rats

M. Wajner, A. Wyse, E. Streck, 2000, Neuroreport.

Impairment of brain redox homeostasis caused by the major metabolites accumulating in hyperornithinemia–hyperammonemia–homocitrullinuria syndrome in vivo

G. Leipnitz, M. Wajner, C. Fernandes, 2012, Metabolic Brain Disease.

Dual mechanism of brain damage induced in vivo by the major metabolites accumulating in hyperornithinemia–hyperammonemia–homocitrullinuria syndrome

A. Sitta, C. Vargas, M. Wajner, 2011, Brain Research.

Intrastriatal hypoxanthine administration affects Na+,K+-ATPase, acetylcholinesterase and catalase activities in striatum, hippocampus and cerebral cortex of rats

M. Wajner, A. Wyse, C. Netto, 2006, International Journal of Developmental Neuroscience.

M. Wajner, C. Fernandes, Paula Pierozan, 2015, Neurotoxicity Research.

Methylmalonic and propionic acids increase the in vitro incorporation of 32 P into cytoskeletal proteins from cerebral cortex of young rats through NMDA glutamate receptors

M. Wajner, R. Pessoa-Pureur, S. Wofchuk, 2000, Brain Research.

Biochemical, histopathological and behavioral alterations caused by intrastriatal administration of quinolic acid to young rats

M. Wajner, C. Fernandes, Paula Pierozan, 2014, The FEBS journal.

Uncoupling, metabolic inhibition and induction of mitochondrial permeability transition in rat liver mitochondria caused by the major long-chain hydroxyl monocarboxylic fatty acids accumulating in LCHAD deficiency.

M. Wajner, A. U. Amaral, R. F. Castilho, 2015, Biochimica et biophysica acta.

Chronic early postnatal glutaric acid administration causes cognitive deficits in the water maze

M. Wajner, C. Ribeiro, G. C. Ferreira, 2008, Behavioural Brain Research.

Sulfite Impairs Bioenergetics and Redox Status in Neonatal Rat Brain: Insights into the Early Neuropathophysiology of Isolated Sulfite Oxidase and Molybdenum Cofactor Deficiencies

G. Leipnitz, M. Wajner, A. Wyse, 2023, Cellular and Molecular Neurobiology.

Neuronal Death, Glial Reactivity, Microglia Activation, Oxidative Stress and Bioenergetics Impairment Caused by Intracerebroventricular Administration of D-2-hydroxyglutaric Acid to Neonatal Rats

G. Leipnitz, M. Wajner, B. Seminotti, 2021, Neuroscience.

The Role of Oxidative Stress and Bioenergetic Dysfunction in Sulfite Oxidase Deficiency: Insights from Animal Models

G. Leipnitz, M. Wajner, A. Wyse, 2018, Neurotoxicity Research.

Experimental evidence for protein oxidative damage and altered antioxidant defense in patients with medium-chain acyl-CoA dehydrogenase deficiency

C. Vargas, M. Wajner, T. Derks, 2014, Journal of Inherited Metabolic Disease.

Toxicity of octanoate and decanoate in rat peripheral tissues: evidence of bioenergetic dysfunction and oxidative damage induction in liver and skeletal muscle

M. Wajner, G. Scaini, E. Streck, 2012, Molecular and Cellular Biochemistry.

Reactive nitrogen species mediate oxidative stress and astrogliosis provoked by in vivo administration of phytanic acid in cerebellum of adolescent rats: A potential contributing pathomechanism of cerebellar injury in peroxisomal disorders

G. Leipnitz, C. Vargas, M. Wajner, 2015, Neuroscience.

Phytanic acid disturbs mitochondrial homeostasis in heart of young rats: a possible pathomechanism of cardiomyopathy in Refsum disease

G. Leipnitz, M. Wajner, M. Grings, 2012, Molecular and Cellular Biochemistry.

Hexacosanoic and docosanoic acids plasma levels in patients with cerebral childhood and asymptomatic X-linked adrenoleukodystrophy: Lorenzo’s oil effect

A. Sitta, C. Vargas, M. Wajner, 2008, Metabolic Brain Disease.

Immunosuppressive effects of organic acids accumulating in patients with maple syrup urine disease

M. Wajner, C. Wannmacher, K. Ckless, 1995, Journal of Inherited Metabolic Disease.

Immunomodulatory action of amino acids on lymphocyte blastogenesis.

M. Wajner, C. Wannmacher, M. B. Fialho, 1992, Biochemical Society transactions.

Inhibition of Creatine Kinase Activity in Vitro by Ethylmalonic Acid in Cerebral Cortex of Young Rats

G. Leipnitz, M. Wajner, C. Ribeiro, 2002, Neurochemical Research.

Incidence of 3-hydroxy-3-methylglutaryl-coenzyme A lyase (HL) deficiency in Brazil, South America

A. Sitta, C. Vargas, M. Wajner, 2008, Journal of Inherited Metabolic Disease.

Disturbance of energy and redox homeostasis and reduction of Na+,K+-ATPase activity provoked by in vivo intracerebral administration of ethylmalonic acid to young rats.

A. Sitta, M. Wajner, A. U. Amaral, 2015, Biochimica et biophysica acta.

Chronic early postnatal administration of ethylmalonic acid to rats causes behavioral deficit

M. Wajner, E. B. Busanello, G. C. Ferreira, 2009, Behavioural Brain Research.

Effect of Propionic and Methylmalonic Acids on the High Molecular Weight Neurofilament Subunit (NF-H) in Rat Cerebral Cortex

M. Wajner, R. Pessoa-Pureur, C. Funchal, 2002, Neurochemical Research.

Ascorbic acid prevents water maze behavioral deficits caused by early postnatal methylmalonic acid administration in the rat

M. Wajner, A. Wyse, C. Dutra-filho, 2003, Brain Research.

Effect of Chemically Induced Propionic Acidemia on Neurobehavioral Development of Rats

C. Vargas, M. Wajner, C. Wannmacher, 1999, Pharmacology Biochemistry and Behavior.

Propionic and methylmalonic acids inhibit the in vitro phosphorylation of a 85 kDa cytoskeletal protein from cerebral cortex of rats

M. Wajner, R. Pessoa-Pureur, M. Freitas, 1998, Neurochemistry International.

Inhibition of succinate dehydrogenase and β-hydroxybutyrate dehydrogenase activities by methylmalonate in brain and liver of developing rats

M. Wajner, C. Dutra-filho, C. Wannmacher, 1993, Journal of Inherited Metabolic Disease.

Ascorbic acid and alpha-tocopherol attenuate methylmalonic acid-induced convulsions.

M. Wajner, C. Queiroz, M. R. Fighera, 1999, Neuroreport.

Effect of the Branched-Chain Alpha-Ketoacids Accumulating in Maple Syrup Urine Disease on the High Molecular Weight Neurofilament Subunit (NF-H) in Rat Cerebral Cortex

M. Wajner, R. Pessoa-Pureur, C. Funchal, 2002, Metabolic Brain Disease.

Selective Screening of Fatty Acids Oxidation Defects and Organic Acidemias by Liquid Chromatography/tandem Mass Spectrometry Acylcarnitine Analysis in Brazilian Patients.

A. Sitta, C. Vargas, M. Wajner, 2018, Archives of medical research.

Induction of a Proinflammatory Response in Cortical Astrocytes by the Major Metabolites Accumulating in HMG-CoA Lyase Deficiency: the Role of ERK Signaling Pathway in Cytokine Release

M. Wajner, C. Fernandes, B. Seminotti, 2015, Molecular Neurobiology.

Evidence that 3-hydroxy-3-methylglutaric and 3-methylglutaric acids induce DNA damage in rat striatum

G. Leipnitz, M. Wajner, B. Seminotti, 2015, Metabolic Brain Disease.

Glutaric acid induces oxidative stress in brain of young rats

M. Wajner, A. Wyse, C. Dutra-filho, 2003, Brain Research.

Inhibition of synaptosomal [3H]glutamate uptake and [3H]glutamate binding to plasma membranes from brain of young rats by glutaric acid in vitro

D. Souza, M. Wajner, T. Emanuelli, 2000, Journal of the Neurological Sciences.

Glutaric Acidemia Type 1: An Inherited Neurometabolic Disorder of Intoxication

M. Wajner, 2021, Handbook of Neurotoxicity.

Acute lysine overload provokes protein oxidative damage and reduction of antioxidant defenses in the brain of infant glutaryl-CoA dehydrogenase deficient mice: A role for oxidative stress in GA I neuropathology

G. Leipnitz, M. Wajner, B. Seminotti, 2014, Journal of the Neurological Sciences.

Glutaric acid moderately compromises energy metabolism in rat brain

C. Vargas, M. Wajner, A. Wyse, 2005, International Journal of Developmental Neuroscience.

Modulation of glutamatergic and GABAergic neurotransmission in glutaryl-CoA dehydrogenase deficiency

D. Souza, M. Wajner, S. Kölker, 2004, Journal of Inherited Metabolic Disease.

Animal models for glutaryl-CoA dehydrogenase deficiency

M. Wajner, S. Kölker, C. Mühlhausen, 2004, Journal of Inherited Metabolic Disease.

In vitro effects of d-2-hydroxyglutaric acid on glutamate binding, uptake and release in cerebral cortex of rats

D. Souza, M. Wajner, A. Wyse, 2004, Journal of the Neurological Sciences.

N-acetylaspartic acid impairs enzymatic antioxidant defenses and enhances hydrogen peroxide concentration in rat brain

M. Wajner, A. Wyse, C. Dutra-filho, 2010, Metabolic Brain Disease.

d-Serine administration provokes lipid oxidation and decreases the antioxidant defenses in rat striatum

G. Leipnitz, M. Wajner, C. Fernandes, 2010, International Journal of Developmental Neuroscience.

In vitro evidence that d-serine disturbs the citric acid cycle through inhibition of citrate synthase activity in rat cerebral cortex

M. Wajner, Patrícia Fernanda Schuck, Moacir Wajner, 2009, Brain Research.

Guanidinoacetate Inhibits Glutamate Uptake in Rat Striatum of Rats at Different Ages

M. Wajner, S. Wofchuk, A. Wyse, 2007, Neurochemical Research.

An overview of L‐2‐hydroxyglutarate dehydrogenase gene (L2HGDH) variants: a genotype–phenotype study

D. Zafeiriou, J. Celli, J. D. den Dunnen, 2010, Human mutation.

Mitochondrial dysfunction, oxidative stress, ER stress and mitochondria-ER crosstalk alterations in a chemical rat model of Huntington's disease: potential benefits of bezafibrate.

G. Leipnitz, M. Wajner, B. Seminotti, 2023, Toxicology letters.

Inhibition of cytochrome c oxidase activity in rat cerebral cortex and human skeletal muscle by D-2-hydroxyglutaric acid in vitro.

G. Leipnitz, M. Wajner, C. Ribeiro, 2002, Biochimica et biophysica acta.

l-2-Hydroxyglutaric Acid Administration to Neonatal Rats Elicits Marked Neurochemical Alterations and Long-Term Neurobehavioral Disabilities Mediated by Oxidative Stress

M. Wajner, A. U. Amaral, C. Netto, 2022, Neurotoxicity Research.

Inhibition of the Mitochondrial Respiratory Chain by Alanine in Rat Cerebral Cortex

M. Wajner, A. Wyse, L. Feksa, 2002, Metabolic Brain Disease.

Evidence that Thiosulfate Inhibits Creatine Kinase Activity in Rat Striatum via Thiol Group Oxidation

G. Leipnitz, M. Wajner, A. Wyse, 2018, Neurotoxicity Research.

Pristanic Acid Provokes Lipid, Protein, and DNA Oxidative Damage and Reduces the Antioxidant Defenses in Cerebellum of Young Rats

D. Souza, C. Vargas, M. Wajner, 2014, The Cerebellum.

G. Leipnitz, M. Wajner, A. Wyse, 2018, Molecular Neurobiology.

Evidence that folic acid deficiency is a major determinant of hyperhomocysteinemia in Parkinson´s disease

C. Vargas, M. Wajner, E. B. Busanello, 2009, Metabolic Brain Disease.

Increased cytokine levels induced by high phenylalanine concentrations in late diagnosis PKU patients compared to early diagnosis: Anti‐inflammatory effect of L‐carnitine

A. Sitta, C. Vargas, M. Wajner, 2023, Cell biochemistry and function.

Inhibition of energy metabolism by 2-methylacetoacetate and 2-methyl-3-hydroxybutyrate in cerebral cortex of developing rats

G. Leipnitz, M. Wajner, C. Ribeiro, 2005, Journal of Inherited Metabolic Disease.

Neurochemical Evidence that the Metabolites Accumulating in 3-Methylcrotonyl-CoA Carboxylase Deficiency Induce Oxidative Damage in Cerebral Cortex of Young Rats

G. Leipnitz, M. Wajner, M. Grings, 2012, Cellular and Molecular Neurobiology.

Induction of a Proinflammatory Response in Cortical Astrocytes by the Major Metabolites Accumulating in HMG-CoA Lyase Deficiency: the Role of ERK Signaling Pathway in Cytokine Release

M. Wajner, C. Fernandes, B. Seminotti, 2016, Molecular Neurobiology.

Long Lasting High Lysine Diet Aggravates White Matter Injury in Glutaryl-CoA Dehydrogenase Deficient (Gcdh−/−) Mice

D. Souza, L. Barbeito, G. Leipnitz, 2018, Molecular Neurobiology.

Quinolinic acid reduces the antioxidant defenses in cerebral cortex of young rats

G. Leipnitz, M. Wajner, A. Wyse, 2005, International Journal of Developmental Neuroscience.

Homocysteine contribution to DNA damage in cystathionine β-synthase-deficient patients.

C. Vargas, M. Wajner, A. Wyse, 2014, Gene.

Brain Na+,K+-ATPase Inhibition Induced by Arginine Administration Is Prevented by Vitamins E and C

M. Wajner, A. Wyse, C. Wannmacher, 2003, Neurochemical Research.

M. Wajner, A. U. Amaral, S. Wajner, 2019, Molecular and Cellular Biochemistry.

Arginine Administration Decreases Cerebral Cortex Acetylcholinesterase and Serum Butyrylcholinesterase Probably by Oxidative Stress Induction

M. Wajner, A. Wyse, F. Stefanello, 2004, Neurochemical Research.

D-2-Hydroxyglutaric Aciduria in a Patient with a Severe Clinical Phenotype and Unusual MRI Findings

C. Vargas, M. Wajner, M. S. van der Knaap, 2002, Journal of Inherited Metabolic Disease.

Oxidative Stress Parameters in Urine from Patients with Disorders of Propionate Metabolism: a Beneficial Effect of l-Carnitine Supplementation

A. Sitta, C. Vargas, M. Wajner, 2011, Cellular and Molecular Neurobiology.

Creatine prevents behavioral alterations caused by methylmalonic acid administration into the hippocampus of rats in the open field task

M. Wajner, V. Vasques, F. Brinco, 2006, Journal of the Neurological Sciences.

Increased susceptibility to quinolinic acid‐induced seizures and long‐term changes in brain oscillations in an animal model of glutaric acidemia type I

M. Calcagnotto, M. Wajner, B. Seminotti, 2021, Journal of neuroscience research.

Elevated levels of BDNF and cathepsin‐d as possible peripheral markers of neurodegeneration in plasma of patients with glutaric acidemia type I

C. Vargas, M. Wajner, Gilian Guerreiro, 2020, International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.

The effect of organic acids on phytohaemagglutinin-activated proliferation of human lymphocytes in vitro.

M. Wajner, C. Wannmacher, J. Schlottfeldt, 1995, International Journal of Immunopharmacology.

Propionic and methylmalonic acids increase cAMP levels in slices of cerebral cortex of young rats via adrenergic and glutamatergic mechanisms.

D. Souza, M. Wajner, S. Loureiro, 2005, Biochimica et biophysica acta.

Ethylmalonic Acid Induces Permeability Transition in Isolated Brain Mitochondria

G. Leipnitz, M. Wajner, A. U. Amaral, 2014, Neurotoxicity Research.

Branched-chain alpha-keto acids accumulating in maple syrup urine disease induce reorganization of phosphorylated GFAP in C6-glioma cells.

M. Wajner, C. Gottfried, A. Zamoner, 2005, Metabolic brain disease.

The influence of organic acids on the proliferation of human peripheral lymphocytes activated by concanavalin A and pokeweed mitogen.

M. Wajner, C. Wannmacher, M. Rocha, 1996, International journal of immunopharmacology.

Effects of histidine and imidazolelactic acid on various parameters of the oxidative stress in cerebral cortex of young rats

M. Wajner, A. Belló-Klein, A. Wyse, 2004, International Journal of Developmental Neuroscience.

Reduced locomotor activity of rats made histidinemic by injection of histidine.

M. Wajner, C. Dutra-filho, C. Wannmacher, 1989, The Journal of nutrition.

Investigation of inflammatory profile in MSUD patients: benefit of L-carnitine supplementation

C. Vargas, M. Wajner, B. Donida, 2015, Metabolic Brain Disease.

ATP diphosphohydrolase activity in synaptosomes from cerebral cortex of rats subjected to chemically induced phenylketonuria.

M. Wajner, A. Wyse, M. Schetinger, 1995, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

α-Tocopherol and Ascorbic Acid Administration Prevents the Impairment of Brain Energy Metabolism of Hyperargininemic Rats

M. Wajner, C. Wannmacher, D. Delwing, 2006, Cellular and Molecular Neurobiology.

Effects of postnatal methylmalonate administration on neurobehavioral development of rats.

M. Wajner, C. Wannmacher, C. F. Mello, 1994, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Glycine disrupts myelin, glutamatergic neurotransmission, and redox homeostasis in a neonatal model for non ketotic hyperglycinemia.

G. Leipnitz, M. Wajner, B. Seminotti, 2023, Biochimie.

In vitro effect of quinolinic acid on energy metabolism in brain of young rats

M. Wajner, A. Wyse, C. Wannmacher, 2007, Neuroscience Research.

D. Souza, G. Leipnitz, M. Wajner, 2015, Journal of Neurological Sciences.

L-2-Hydroxyglutaric aciduria: pattern of MR imaging abnormalities in 56 patients.

D. Zafeiriou, G. Uziel, M. Wajner, 2009, Radiology.

Disruption of Brain Redox Homeostasis, Microglia Activation and Neuronal Damage Induced by Intracerebroventricular Administration of S-Adenosylmethionine to Developing Rats

G. Leipnitz, M. Wajner, A. Wyse, 2018, Molecular Neurobiology.

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

C. Vargas, M. Wajner, C. Dutra-filho, 2015 .

Increased peripheral of brain-derived neurotrophic factor levels in phenylketonuric patients treated with l-carnitine.

A. Sitta, C. Vargas, M. Wajner, 2023, Archives of biochemistry and biophysics.

Effect of postnatal methylmalonate administration on adult rat behavior.

M. Wajner, C. Wannmacher, R. Pires, 1991, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

C. Vargas, M. Wajner, L. Vilarinho, 2015, Cellular and Molecular Neurobiology.

Mitochondrial dysfunction in fatty acid oxidation disorders: insights from human and animal studies

M. Wajner, A. U. Amaral, 2015, Bioscience reports.

Inhibition of In‐vitro Lymphocyte Transformation by the Isoquinoline Alkaloid Berberine

M. Wajner, M. Pasqual, P. Moyna, 1995, The Journal of pharmacy and pharmacology.

Chronic Exposure to β-Alanine Generates Oxidative Stress and Alters Energy Metabolism in Cerebral Cortex and Cerebellum of Wistar Rats

M. Wajner, C. Dutra-filho, C. Wannmacher, 2017, Molecular Neurobiology.

Inhibition of Rat Brain Lipid Synthesis In Vitro by 4-Hydroxybutyric Acid

M. Wajner, C. Ruschel, C. Dutra-filho, 1999, Metabolic Brain Disease.

Inhibition of brain energy metabolism by the α-keto acids accumulating in maple syrup urine disease

M. Wajner, C. Ribeiro, A. Wyse, 2003 .

Tay-sachs disease heterozygote detection in Brazil: Comparison between tears and leukocytes as β-hexosaminidase a source