D. Serra

发表

Structural (betaalpha)8 TIM barrel model of 3-hydroxy-3-methylglutaryl-coenzyme A lyase.

A. Valencia, R. Aledo, B. Puisac, 2003, The Journal of biological chemistry.

Ten novel HMGCL mutations in 24 patients of different origin with 3‐hydroxy‐3‐methyl‐glutaric aciduria

B. Puisac, M. Arnedo, C. Pérez-Cerdá, 2009, Human mutation.

Localization of an exonic splicing enhancer responsible for mammalian natural trans-splicing.

A. Graessmann, F. Hegardt, D. Serra, 2001, Nucleic acids research.

Definition by Functional and Structural Analysis of Two Malonyl-CoA Sites in Carnitine Palmitoyltransferase 1A*

P. Gómez-Puertas, F. Hegardt, D. Serra, 2007, Journal of Biological Chemistry.

Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation.

F. Villarroya, N. Casals, D. Serra, 2015, American journal of physiology. Endocrinology and metabolism.

Molecular therapy for obesity and diabetes based on a long‐term increase in hepatic fatty‐acid oxidation

H. Petry, F. Hegardt, D. Serra, 2011, Hepatology.

Mitochondrial fatty acid oxidation in obesity.

D. Serra, Laura Herrero, Maria Ida Malandrino, 2013, Antioxidants & redox signaling.

Effects of High-Fat Diet and Maternal Binge-Like Alcohol Consumption and Their Influence on Cocaine Response in Female Mice Offspring

O. Valverde, D. Serra, L. Cantacorps, 2020, The international journal of neuropsychopharmacology.

Modulation in vitro of H-ras oncogene expression by trans-splicing

A. Graessmann, F. Hegardt, D. Serra, 2001, Oncogene.

Processing of carnitine octanoyltransferase pre-mRNAs by cis and trans-splicing.

F. Hegardt, D. Serra, G. Asins, 1999, Advances in experimental medicine and biology.

Mechanisms of Impaired Brown Adipose Tissue Recruitment in Obesity

D. Serra, M. Calderon-Dominguez*, Laura Herrero, 2019, Front. Physiol..

Hypothalamic endocannabinoids inversely correlate with the development of diet-induced obesity in male and female mice[S]

N. Casals, D. Serra, Laura Herrero, 2019, Journal of Lipid Research.

Fatty acid metabolism and the basis of brown adipose tissue function

D. Serra, M. Calderon-Dominguez*, Laura Herrero, 2015, Adipocyte.

Impact of Adaptive Thermogenesis in Mice on the Treatment of Obesity

D. Serra, Laura Herrero, Paula Mera, 2020, Cells.

Low-density lipoprotein receptor-related protein 1 deficiency in cardiomyocytes reduces susceptibility to insulin resistance and obesity.

A. Bayés‐Genís, D. Serra, C. Soler‐Botija, 2020, Metabolism: clinical and experimental.

Renal tubule Cpt1a overexpression mitigates kidney fibrosis by restoring mitochondrial homeostasis

D. Serra, C. Barbas, S. Ortega, 2020, bioRxiv.

Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins.

C. Kahn, B. Gibson, J. Meyer, 2019, Cell metabolism.

Inhibition of fatty acid synthesis induces differentiation and reduces tumor burden in childhood neuroblastoma

R. Nilsson, J. Bergquist, A. Schulze, 2021, iScience.

Central Ceramide-Induced Hypothalamic Lipotoxicity and ER Stress Regulate Energy Balance

N. Casals, D. Serra, D. Morgan, 2014, Cell reports.

Brown Adipose Tissue in Obesity and Diabetes

D. Serra, Laura Herrero, M. Viana, 2020 .

New approaches targeting brown adipose tissue transplantation as a therapy in obesity.

D. Serra, Laura Herrero, Paula Mera, 2018, Biochemical pharmacology.

Use of Infrared Thermography to Estimate Brown Fat Activation After a Cooling Protocol in Patients with Severe Obesity That Underwent Bariatric Surgery

F. Villarroya, C. Lerin, D. Serra, 2020, Obesity Surgery.

Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes.

Á. Valverde, D. Serra, M. Obregon, 2016, Biochimica et biophysica acta.

CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy

N. Casals, D. Serra, Joan F Mir, 2018, Scientific Reports.

Infusion of Phagocytic Macrophages Overexpressing CPT1a Ameliorates Kidney Fibrosis in the UUO Model

D. Serra, Soraya Játiva, A. Solà, 2021, Cells.

Malonyl-CoA mediates leptin hypothalamic control of feeding independent of inhibition of CPT-1a.

N. Casals, F. Hegardt, D. Serra, 2011, American journal of physiology. Regulatory, integrative and comparative physiology.

Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues.

F. Hegardt, J. Clotet, D. Serra, 2000, The Biochemical journal.

Central Ceramide-Induced H ypothalamic Lipotoxicity and ER Stress Regulate Energy Balance Graphical

N. Casals, D. Serra, D. Morgan, 2014 .

Hypothalamic Ceramide Levels Regulated by CPT1C Mediate the Orexigenic Effect of Ghrelin

N. Casals, F. Hegardt, J. Clotet, 2013, Diabetes.

Ptpn1 deletion protects oval cells against lipoapoptosis by favoring lipid droplet formation and dynamics.

M. Moreno-Aliaga, J. Balsinde, P. Rada, 2022, Cell death and differentiation.

Angiocrine polyamine production regulates adiposity

A. Carracedo, D. Serra, P. Castel, 2022, Nature Metabolism.

Enhancing Hepatic Fatty Acid Oxidation as a Strategy for Reversing Metabolic Disorders Programmed by Maternal Undernutrition During Gestation

D. Serra, C. Picó, A. Palou, 2014, Cellular Physiology and Biochemistry.

The effect of etomoxir on the mRNA levels of enzymes involved in ketogenesis and cholesterogenesis in rat liver.

F. Hegardt, D. Serra, G. Asins, 1994, Biochemical pharmacology.

The effect of dexamethasone treatment on the expression of the regulatory genes of ketogenesis in intestine and liver of suckling rats

F. Hegardt, D. Serra, G. Asins, 1998, Molecular and Cellular Biochemistry.

Inhibition of carnitine palmitoyl-transferase 1A in hepatic stellate cells protects against fibrosis.

R. Schwabe, D. Serra, M. Schwaninger, 2022, Journal of hepatology.

Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function.

D. Serra, M. Schwaninger, M. Martínez-Chantar, 2021, Journal of hepatology.

Essential role of Nrf2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes.

M. Moreno-Aliaga, Á. Valverde, A. Cuadrado, 2015, Free radical biology & medicine.

Short-term vitamin E treatment impairs reactive oxygen species signaling required for adipose tissue expansion, resulting in fatty liver and insulin resistance in obese mice

D. Serra, M. Calderon-Dominguez*, Laura Herrero, 2017, PloS one.

Vitamin E reduces adipose tissue fibrosis, inflammation, and oxidative stress and improves metabolic profile in obesity

D. Serra, Laura Herrero, M. Viana, 2015, Obesity.

Novel role of FATP 1 in mitochondrial fatty acid oxidation in skeletal muscle cells

F. Hegardt, D. Serra, G. Asins, 2009 .

Fatty acids are a major energy source for skeletal muscle. They are transported into the cell via a protein-mediated mechanism, involving fatty acid translocase/CD36 (FAT/

F. Hegardt, D. Serra, G. Asins, 2009 .

Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells

F. Hegardt, D. Serra, G. Asins, 2009, Journal of Lipid Research.

Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth

N. Casals, D. Serra, H. Hayen, 2019, eLife.

Purification and characterization of a protein inhibitor from rat liver that inhibits type 1 protein phosphatase when 3h yd roxy-3m et hy lg I u tary I CoA reductase is the substrate

D. Serra, G. Asins, 2002 .

Isolation and partial characterization of a protein with HMG-CoA reductase phosphatase activity associated with rat liver microsomal membranes.

F. Hegardt, D. Serra, G. Asins, 1991, Journal of lipid research.

Purification and characterization of a protein inhibitor from rat liver that inhibits type 1 protein phosphatase when 3-hydroxy-3-methylglutaryl CoA reductase is the substrate.

F. Hegardt, D. Serra, G. Asins, 1990, Journal of lipid research.

Influence of etomoxir on the expression of several genes in liver, testis and heart.

F. Hegardt, D. Serra, G. Asins, 1995, General pharmacology.

Structural (βα)8 TIM Barrel Model of 3-Hydroxy-3-methylglutaryl-Coenzyme A Lyase*

A. Valencia, R. Aledo, B. Puisac, 2003, Journal of Biological Chemistry.

CPT1c Is Localized in Endoplasmic Reticulum of Neurons and Has Carnitine Palmitoyltransferase Activity*

N. Casals, F. Hegardt, J. Clotet, 2008, Journal of Biological Chemistry.

Ceramide Levels Regulated by Carnitine Palmitoyltransferase 1C Control Dendritic Spine Maturation and Cognition*

M. Dierssen, N. Casals, F. Hegardt, 2012, The Journal of Biological Chemistry.

Role of long non-coding RNAs in adipose tissue metabolism and associated pathologies.

D. Serra, J. Ponce-González, M. Calderon-Dominguez*, 2022, Biochemical pharmacology.

White adipose tissue dysfunction in obesity and aging.

D. Serra, Laura Herrero, D. Sánchez-Infantes, 2021, Biochemical pharmacology.

Important role of ventromedial hypothalamic carnitine palmitoyltransferase-1a in the control of food intake.

F. Hegardt, D. Serra, Wendy Keung, 2013, American journal of physiology. Endocrinology and metabolism.

Adenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretion.

C. Wollheim, F. Hegardt, D. Serra, 2002, The Biochemical journal.

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis.

D. Serra, C. Barbas, S. Ortega, 2021, The Journal of clinical investigation.

Impaired hepatic fatty acid oxidation in rats with short-term cholestasis: characterization and mechanism.

M. Schäfer, S. Krähenbühl, F. Hegardt, 2001, Journal of lipid research.

The effect of fasting/refeeding and insulin treatment on the expression of the regulatory genes of ketogenesis in intestine and liver of suckling rats.

F. Hegardt, D. Serra, G. Asins, 1997, Archives of biochemistry and biophysics.

Regulation of mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase protein by starvation, fat feeding, and diabetes.

N. Casals, F. Hegardt, D. Serra, 1993, Archives of biochemistry and biophysics.

Convenient synthesis of C75, an inhibitor of FAS and CPT1

E. Nicolás, F. Hegardt, D. Serra, 2013 .

Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells

N. Auersperg, F. Hegardt, D. Serra, 2015, International journal of cancer.

Identification of the two histidine residues responsible for the inhibition by malonyl‐CoA in peroxisomal carnitine octanoyltransferase from rat liver

F. Hegardt, J. Clotet, D. Serra, 2000, FEBS letters.

Impaired ketogenesis is a major mechanism for disturbed hepatic fatty acid metabolism in rats with long-term cholestasis and after relief of biliary obstruction.

M. Schäfer, S. Krähenbühl, F. Hegardt, 2002, Journal of hepatology.

Spine Maturation and Cognition Palmitoyltransferase 1C Control Dendritic Ceramide Levels Regulated by Carnitine Lipids

M. Dierssen, D. Serra, A. Acker-Palmer, 2013 .

Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells

Chuan He, G. Bhagat, D. Serra, 2020, Gut.

Identification of Conserved Amino Acid Residues in Rat Liver Carnitine Palmitoyltransferase I Critical for Malonyl-CoA Inhibition

Alfonso Valencia, Montserrat Morillas, Paulino Gómez-Puertas, 2003, The Journal of Biological Chemistry.

Structural Model of a Malonyl-CoA-binding Site of Carnitine Octanoyltransferase and Carnitine Palmitoyltransferase I

Alfonso Valencia, Josep Clotet, Montserrat Morillas, 2002, The Journal of Biological Chemistry.

Structural model of carnitine palmitoyltransferase I based on the carnitine acetyltransferase crystal.

Alfonso Valencia, Eduardo López-Viñas, Montserrat Morillas, 2004, The Biochemical journal.

(-)-UB006: A new fatty acid synthase inhibitor and cytotoxic agent without anorexic side effects.

F. Hegardt, D. Serra, G. Asins, 2017, European journal of medicinal chemistry.

Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity.

F. Hegardt, D. Serra, G. Asins, 2013, Chirality.

Dietary Options for Rodents in the Study of Obesity

D. Serra, Laura Herrero, Marianela Bastías-Pérez, 2020, Nutrients.

Natural trans-splicing in carnitine octanoyltransferase pre-mRNAs in rat liver.

F. Hegardt, D. Serra, G. Asins, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+ breast cancer.

E. Cuyás, B. Martín-Castillo, J. Menéndez, 2017, Histology and histopathology.

Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice

N. Casals, D. Serra, Laura Herrero, 2017, Scientific Reports.

To be or not to be a fat burner, that is the question for cpt1c in cancer cells

N. Casals, D. Serra, Laura Herrero, 2023, Cell Death & Disease.

Poly-ion complex micelles effectively deliver CoA-conjugated CPT1A inhibitors to modulate lipid metabolism in brain cells.

S. Fukushima, K. Kataoka, N. Casals, 2021, Biomaterials science.

CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy

N. Casals, D. Serra, M. Atari, 2018, Scientific Reports.

HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism

S. Welford, B. Rini, S. Campbell, 2017, Nature Communications.

Hypothalamic Regulation of Liver and Muscle Nutrient Partitioning by Brain-Specific Carnitine Palmitoyltransferase 1C in Male Mice

N. Casals, D. Serra, Sara Ramírez, 2017, Endocrinology.

Carnitine palmitoyltransferase 1C: From cognition to cancer.

N. Casals, D. Serra, Laura Herrero, 2016, Progress in lipid research.

Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER 2 + breast cancer

E. Cuyás, B. Martín-Castillo, J. Menéndez, 2016 .

HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism

S. Welford, B. Rini, S. Campbell, 2017, Nature Communications.

Novel effect of C75 on carnitine palmitoyltransferase I activity and palmitate oxidation.

P. Gómez-Puertas, F. Hegardt, D. Serra, 2006, Biochemistry.

Carnitine palmitoyltransferase 1 C : From cognition to cancer

N. Casals, D. Serra, Laura Herrero, 2015 .

CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance.

F. Hegardt, D. Serra, G. Asins, 2007, American journal of physiology. Endocrinology and metabolism.

An overview of nanomedicines for neuron targeting.

N. Casals, D. Serra, Shihori Tanabe, 2020, Nanomedicine.

Ghrelin Causes a Decline in GABA Release by Reducing Fatty Acid Oxidation in Cortex

A. Ribes, N. Casals, D. Serra, 2018, Molecular Neurobiology.

C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight.

Antonio G. Cordente, P. Gómez-Puertas, F. Hegardt, 2009, Biochemical pharmacology.

Hypothalamus-skeletal muscle crosstalk during exercise and its role in metabolism modulation.

D. Serra, Laura Herrero, Paula Mera, 2021, Biochemical pharmacology.

Brown Adipose Tissue Bioenergetics: A New Methodological Approach

D. Serra, A. Zorzano, David Sebastián, 2017, Advanced science.

Alteration of the malonyl-CoA/carnitine palmitoyltransferase I interaction in the beta-cell impairs glucose-induced insulin secretion.

Marc Prentki, Dolors Serra, Laura Herrero, 2005, Diabetes.

Ceramides and mitochondrial fatty acid oxidation in obesity

N. Casals, D. Serra, Laura Herrero, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Carnitine Palmitoyltransferase 1 Increases Lipolysis, UCP1 Protein Expression and Mitochondrial Activity in Brown Adipocytes

Á. Valverde, D. Serra, A. Zorzano, 2016, PloS one.

I overexpression protects L 6 E 9 muscle cells from fatty acid-induced insulin resistance

F. Hegardt, D. Serra, G. Asins, 2007 .

The role of epigenetics in the development of obesity.

D. Serra, Laura Herrero, Paula Mera, 2020, Biochemical pharmacology.

Moderate SIRT1 overexpression protects against brown adipose tissue inflammation

Á. Valverde, D. Serra, M. Obregon, 2020, Molecular Metabolism.

Liver CPT1A gene therapy reduces diet‐induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD

G. Frühbeck, R. Bartrons, N. Casals, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Long-Term Increased Carnitine Palmitoyltransferase 1A Expression in Ventromedial Hypotalamus Causes Hyperphagia and Alters the Hypothalamic Lipidomic Profile

H. Petry, F. Hegardt, D. Serra, 2014, PloS one.

C 75 is converted to C 75-CoA in the hypothalamus , where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight

Antonio G. Cordente, P. Gómez-Puertas, F. Hegardt, 2009 .

Mutagenesis of specific amino acids converts carnitine acetyltransferase into carnitine palmitoyltransferase.

Antonio G. Cordente, P. Gómez-Puertas, F. Hegardt, 2006, Biochemistry.

Redesign of Carnitine Acetyltransferase Specificity by Protein Engineering*

Antonio G. Cordente, Isak S. Pretorius, Fausto G. Hegardt, 2004, Journal of Biological Chemistry.

Structural Model of the Catalytic Core of Carnitine Palmitoyltransferase I and Carnitine Octanoyltransferase (COT)

Montserrat Morillas, Fausto G. Hegardt, Dolors Serra, 2001, The Journal of Biological Chemistry.

Developmental changes in carnitine octanoyltransferase gene expression in intestine and liver of suckling rats.

F. Hegardt, D. Serra, G. Asins, 2001, Archives of biochemistry and biophysics.

Developmental changes in carnitine palmitoyltransferases I and II gene expression in intestine and liver of suckling rats.

F. Hegardt, D. Serra, G. Asins, 1995, The Biochemical journal.

White adipose tissue-infiltrated CD11b+ myeloid cells are a source of S100A4, a new potential marker of hepatic damage.

F. Villarroya, D. Serra, M. Puig Domingo, 2021, European journal of endocrinology.

Mitochondrial 3-hydroxy-3-methylglutaryl coenzyme A synthase and carnitine palmitoyltransferase II as potential control sites for ketogenesis during mitochondrion and peroxisome proliferation.

L. Madsen, F. Hegardt, D. Serra, 1999, Biochemical pharmacology.

Corrigendum to "The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling" [Metab Clin Exp 85 (2018) 59-75].

D. Serra, J. Vendrell, J. Pizarro, 2019, Metabolism: Clinical and Experimental.

The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling.

D. Serra, J. Vendrell, J. Pizarro, 2018, Metabolism: clinical and experimental.

The expression of mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme-A synthase in neonatal rat intestine and liver is under transcriptional control.

F. Hegardt, D. Serra, G. Asins, 1996, European journal of biochemistry.

Targeting AgRP neurons to maintain energy balance: Lessons from animal models

D. Serra, Laura Herrero, Paula Mera, 2018, Biochemical pharmacology.

Moderate SIRT1 overexpression protects against inflammation of brown adipose tissue.

Á. Valverde, D. Serra, M. Obregon, 2020, Molecular metabolism.

CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst

R. Palmiter, N. Casals, D. Serra, 2023, Biology of Sex Differences.

Altered Circadian Rhythm and Metabolic Gene Profile in Rats Subjected to Advanced Light Phase Shifts

D. Serra, A. Díez-Noguera, T. Cambras, 2015, PloS one.

CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity

N. Casals, D. Serra, Miguel López, 2018, Molecular metabolism.

Implantation of CPT1AM-expressing adipocytes reduces obesity and glucose intolerance in mice.

A. Consiglio, N. Casals, D. Serra, 2023, Metabolic engineering.

3D bioprinted functional skeletal muscle models have potential applications for studies of muscle wasting in cancer cachexia.

A. Efeyan, A. Sagrera, D. Serra, 2023, Biomaterials advances.

Preparation of α-labeled aldehydes by base-catalyzed exchange reactions

F. Hegardt, D. Serra, G. Asins, 2010 .

Central Regulation of Brown Fat Thermogenesis in Response to Saturated or Unsaturated Long-Chain Fatty Acids

N. Casals, D. Serra, Laura Herrero, 2023, International journal of molecular sciences.

Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance.

K. Toh, S. Fukushima, K. Kataoka, 2023, Biomaterials science.

Tissue-specific Expression and Dietary Regulation of Chimeric Mitochondrial 3-Hydroxy-3-methylglutaryl Coenzyme A Synthase/Human Growth Hormone Gene in Transgenic Mice (*)

F. Hegardt, D. Serra, F. Bosch, 1996, The Journal of Biological Chemistry.

Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase promoter contains a CREB binding site that regulates cAMP action in Caco-2 cells.

F. Hegardt, D. Serra, G. Asins, 2000, The Biochemical journal.

Cellular Physiology and Biochemistry Cellular Physiology and Biochemistry Enhancing Hepatic Fatty Acid Oxidation as a Strategy for Reversing Metabolic Disorders Programmed by Maternal Undernutrition during Gestation Cellular Physiology and Biochemistry Cellular Physiology and Biochemistry

D. Serra, C. Picó, A. Palou, 2022 .

Adipose Tissue Dynamics: Cellular and Lipid Turnover in Health and Disease

D. Serra, Laura Herrero, Ivonne Palacios-Marin, 2023, Nutrients.