C. Lacout

发表

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

Stefan N. Constantinescu, William Vainchenker, S. Constantinescu, 2005, Nature.

An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor.

W. Vainchenker, J. Staerk, C. Lacout, 2006, Blood.

Role for the nuclear factor kappaB pathway in transforming growth factor-beta1 production in idiopathic myelofibrosis: possible relationship with FK506 binding protein 51 overexpression.

W. Vainchenker, N. Debili, V. Penard-Lacronique, 2005, Cancer research.

JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis.

W. Vainchenker, M. Tulliez, C. Lacout, 2006, Blood.

Thrombopoietin (TPO) knockout phenotype induced by cross-reactive antibodies against TPO following injection of mice with recombinant adenovirus encoding human TPO.

W. Vainchenker, N. Debili, H. Haddada, 1998, Journal of immunology.

X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome A defect in hematopoietic stem cell migration explains the nonrandom

E. Haddad, W. Vainchenker, S. Snapper, 2012 .

A defect in hematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome.

E. Haddad, W. Vainchenker, S. Snapper, 2003, Blood.

BCR–ABL activates STAT3 via JAK and MEK pathways in human cells

S. Flamant, W. Vainchenker, C. Lacout, 2006, British journal of haematology.

Use of the 46/1 haplotype to model JAK2V617F clonal architecture in PV patients: clonal evolution and impact of IFNα treatment

E. Solary, W. Vainchenker, J. P. Couédic, 2014, Leukemia.

Hemostatic disorders in a JAK2V617F-driven mouse model of myeloproliferative neoplasm.

W. Vainchenker, C. Denis, C. Lacout, 2014, Blood.

A role for reactive oxygen species in JAK2V617F myeloproliferative neoplasm progression

E. Solary, W. Vainchenker, J. P. Couédic, 2013, Leukemia.

JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNα.

E. Solary, W. Vainchenker, C. Lacout, 2013, Blood.

osteosclerosis induced by high thrombopoietin levels in mice Proteasome inhibitor bortezomib impairs both myelofibrosis and

W. Vainchenker, M. Tulliez, C. Lacout, 2013 .

Proteasome inhibitor bortezomib impairs both myelofibrosis and osteosclerosis induced by high thrombopoietin levels in mice.

W. Vainchenker, M. Tulliez, C. Lacout, 2007, Blood.

Constitutive activation of STAT5 and Bcl-xL overexpression can induce endogenous erythroid colony formation in human primary cells.

W. Vainchenker, C. James, V. Ugo, 2005, Blood.

A unique clonal JAK 2 mutation leading to constitutive signalling causes polycythaemia

S. Constantinescu, H. Raslova, R. Berger, 2005 .

Role for the nuclear factor kappaB pathway in transforming growth factor-beta1 production in idiopathic myelofibrosis: possible relationship with FK506 binding protein 51 overexpression.

W. Vainchenker, N. Debili, V. Penard-Lacronique, 2005, Cancer research.

Gfi-1B plays a critical role in terminal differentiation of normal and transformed erythroid progenitor cells.

W. Vainchenker, C. Lacout, L. Garçon, 2005, Blood.

Inhibition of erythroid differentiation and induction of megakaryocytic differentiation by thrombopoietin are regulated by two different mechanisms in TPO-dependent UT-7/c-mpl and TF-1/c-mpl cell lines

W. Vainchenker, C. Lacout, K. Cohen-Solal, 1998, Leukemia.

Murine pluripotent hematopoietic progenitors constitutively expressing a normal erythropoietin receptor proliferate in response to erythropoietin without preferential erythroid cell differentiation

W. Vainchenker, C. Lacout, F. Féger, 1994, Molecular and cellular biology.

Major effects of TPO delivered by a single injection of a recombinant adenovirus on prevention of septicemia and anemia associated with myelosuppression in mice: risk of sustained expression inducing myelofibrosis due to immunosuppression

W. Vainchenker, N. Debili, H. Haddada, 1998, Gene Therapy.

Recombinant Adenovirus Encoding Human TPO TPO Following Injection of Mice with Induced by Cross-Reactive Antibodies Against Thrombopoietin ( TPO ) Knockout Phenotype

W. Vainchenker, N. Debili, F. Wendling, 1998 .

Thrombopoietin does not induce lineage-restricted commitment of Mpl-R expressing pluripotent progenitors but permits their complete erythroid and megakaryocytic differentiation.

W. Vainchenker, F. Wendling, C. Lacout, 1997, Blood.

Ligand-independent Thrombopoietin Mutant Receptor Requires Cell Surface Localization for Endogenous Activity*

W. Vainchenker, C. Lacout, J. Villeval, 2009, Journal of Biological Chemistry.

Pluripotent stem cells constitutively expressing a normal erythropoietin receptor give rise to normal hematopoiesis in lethally irradiated recipient mice.

W. Vainchenker, C. Lacout, A. Dubart, 1996, Experimental Hematology.

Proteasome Inhibitor Bortezomib Can Inhibit Bone Marrow Fibrosis Development in a Murine Model of Myelofibrosis.

W. Vainchenker, M. Tulliez, C. Lacout, 2005 .

Gﬁ-1B plays a critical role in terminal differentiation of normal and transformed erythroid progenitor cells

W. Vainchenker, J. P. Couédic, C. Lacout, 2005 .

Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice.

W. Vainchenker, C. Lacout, J. Villeval, 2010, Blood.

Brief report Myeloproliferative neoplasm induced by constitutive expression of JAK2 V617F in knock-in mice

W. Vainchenker, C. Lacout, J. Villeval, 2010 .

The granulocyte colony‐stimulating factor receptor supports erythroid differentiation in the absence of the erythropoietin receptor or Stat5

W. Vainchenker, C. Lacout, F. Svinarchuk, 2001, British journal of haematology.

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera.

Stefan N Constantinescu, William Vainchenker, S. Constantinescu, 2005, Nature.

LYL-1 deficiency induces a stress erythropoiesis.

F. Sablitzky, W. Vainchenker, C. Lacout, 2011, Experimental hematology.

The SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiation.

F. Sablitzky, W. Vainchenker, C. Lacout, 2006, Blood.

HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis

François Girodon, Fernando Rodrigues-Lima, Isabelle Plo, 2018, Nature Communications.

Ectopic expression of the erythropoietin receptor in a murine interleukin-6-dependent plasmacytoma cell line (TEPC-2027) confers proliferative responsiveness to erythropoietin.

W. Vainchenker, C. Lacout, I. Dusanter-Fourt, 1997, Blood.

JAK2V617F Promotes Stem Cell Amplification Driving MPN Clonal Dominance in Mice and Treatment by IFNa Prevents This Effect

E. Solary, W. Vainchenker, C. Lacout, 2011 .

JAK2 inhibition has different therapeutic effects according to myeloproliferative neoplasm development in mice

W. Vainchenker, C. Lacout, J. Villeval, 2015, Journal of cellular and molecular medicine.

HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis

M. Gleave, C. Garrido, R. Skoda, 2018, Nature Communications.

P19INK4D links endomitotic arrest and megakaryocyte maturation and is regulated by AML-1.

D. Bluteau, W. Vainchenker, N. Debili, 2008, Blood.

A miR-150/TET3 pathway regulates the generation of mouse and human non-classical monocyte subset

E. Solary, O. Bernard, C. Lacout, 2018, Nature Communications.

Multistage hematopoietic stem cell regulation in the mouse: A combined biological and mathematical approach

S. Méléard, C. Lacout, Céline Bonnet, 2021, iScience.

Adenoviral-mediated TGF-beta1 inhibition in a mouse model of myelofibrosis inhibit bone marrow fibrosis development.

M. Perricaudet, W. Vainchenker, M. Tulliez, 2007, Experimental hematology.

Kit-activating mutations cooperate with Spi-1/PU.1 overexpression to promote tumorigenic progression during erythroleukemia in mice.

W. Vainchenker, N. Denis, F. Moreau-Gachelin, 2005, Cancer cell.

JAK2 and MPL protein levels determine TPO-induced megakaryocyte proliferation vs differentiation.

F. Pasquier, E. Solary, W. Vainchenker, 2014, Blood.

A major role of TGF-beta1 in the homing capacities of murine hematopoietic stem cell/progenitors.

W. Vainchenker, C. Lacout, A. Bennaceur-Griscelli, 2010, Blood.

SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice

O. Abdel-Wahab, E. Solary, W. Vainchenker, 2023, Leukemia.

Zyxin is up-regulated during megakaryocytic differentiation of human UT-7/c-mpl cells.

C. Auffray, W. Vainchenker, C. Lacout, 2004, Biochemical and biophysical research communications.

Caspase Inhibition Modulates Monocyte-Derived Macrophage Polarization in Damaged Tissues

P. Vandenabeele, E. Solary, J. Martinou, 2023, International journal of molecular sciences.

A miR-150/TET3 pathway regulates the generation of mouse and human non-classical monocyte subset

E. Solary, O. Bernard, C. Lacout, 2018, Nature Communications.

Infection with a Kirsten-retrovirus can induce a multiplicity of tumorigenic phenotypes in the interleukin-3-dependent FDC-P1 cells.

C. Lacout, F. Dautry, D. Duménil, 1994, Experimental hematology.