C. L. van der Wilt

发表

Basis for effective combination cancer chemotherapy with antimetabolites.

G. Peters, G. J. Peters, C. L. van der Wilt, 2000, Pharmacology & therapeutics.

Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.

G. Peters, C. L. van der Wilt, G. Jansen, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers.

G. Peters, S. Meijer, C. L. van der Wilt, 2004, Annals of oncology : official journal of the European Society for Medical Oncology.

Long-term survival data of triple modality treatment of stage IIB–III–IVA cervical cancer with the combination of radiotherapy, chemotherapy and hyperthermia – an update

J. van der Zee, P. Koper, L. Prosnitz, 2012, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Increased sensitivity to gemcitabine of P-glycoprotein and multidrug resistance-associated protein-overexpressing human cancer cell lines

G. Peters, I. Talianidis, C. L. van der Wilt, 2003, British Journal of Cancer.

Folate depletion increases sensitivity of solid tumor cell lines to 5‐fluorouracil and antifolates

G. Peters, C. L. van der Wilt, G. Jansen, 2000, International journal of cancer.

Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil.

S. Meijer, C. L. van der Wilt, H. Pinedo, 1994, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity.

G. Peters, I. Talianidis, C. L. van der Wilt, 2002, Molecular cancer therapeutics.

Isolated liver perfusion versus hepatic artery infusion with 5-fluorouracil in a rat model; effects on thymidylate synthase.

G. Peters, C. L. van der Wilt, J. Cloos, 1991, Advances in experimental medicine and biology.

Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed.

C. L. van der Wilt, B. van Triest, H. Pinedo, 2000, European journal of cancer.

Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase.

G. Peters, C. L. van der Wilt, J. Cloos, 1992, Seminars in oncology.

Addition of leucovorin in modulation of 5‐fluorouracil with methotrexate: Potentiating or reversing effect?

G. Peters, C. L. van der Wilt, H. Pinedo, 1995, International journal of cancer.

Therapeutic efficacy of fluoropyrimidines depends on the duration of thymidylate synthase inhibition in the murine colon 26-B carcinoma tumor model.

G. Peters, Y. Rustum, C. L. van der Wilt, 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

Time course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin.

G. Peters, S. Meijer, C. L. van der Wilt, 1992, Seminars in oncology.

Thymidylate synthase and drug resistance.

P. Johnston, C. L. van der Wilt, B. van Triest, 1995, European journal of cancer.

A Non‐Radioactive Sensitive Assay to Measure 5‐Fluorouracil Incorporation into DNA of Solid Tumors

G. Peters, C. L. van der Wilt, P. Noordhuis, 2004, Nucleosides, nucleotides & nucleic acids.

CI-994 (N-acetyl-dinaline) in combination with conventional anti-cancer agents is effective against acute myeloid leukemia in vitro and in vivo.

G. Peters, C. L. van der Wilt, G. Kaspers, 2008, Oncology reports.

Selective Protection by Uridine of Growth Inhibition by 5-Fluorouracil (5FU) Mediated by 5FU Incorporation into RNA, But Not the Thymidylate Synthase Mediated Growth Inhibition by 5FU-Leucovorin

G. Peters, C. L. van der Wilt, P. Noordhuis, 2008, Nucleosides, nucleotides & nucleic acids.

High-Dose 5-Fluorouracil with Uridine-Diphosphoglucose Rescue Increases Thymidylate Synthase Inhibition but Not 5-Fluorouracil Incorporation into RNA in Murine Tumors

G. Peters, C. L. van der Wilt, H. Pinedo, 2002, Oncology.

5-Fluorouracil/leucovorin-induced inhibition of thymidylate synthase in normal tissues of mouse and man

G. Peters, S. Meijer, C. L. van der Wilt, 1997, Journal of Cancer Research and Clinical Oncology.

Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors.

G. Peters, C. L. van der Wilt, H. Pinedo, 1992, Cancer research.

Thymidylate synthase inhibition induces p53 dependent and independent cell death.

G. Peters, C. L. van der Wilt, H. Pinedo, 2000, Advances in experimental medicine and biology.

The role of thymidine kinase activity in murine colon tumours treated with 5-fluorouracil.

G. Peters, C. L. van der Wilt, K. Smid, 1997, Advances in experimental medicine and biology.

Modulation of 5-fluorouracil in mice using uridine diphosphoglucose.

G. Peters, D. Martin, J. Colofiore, 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

Antitumour activity, toxicity and inhibition of thymidylate synthase of prolonged administration of 5-fluorouracil in mice.

G. Peters, C. L. van der Wilt, H. Pinedo, 1995, European journal of cancer.

Comparison of 5-fluoro-2'-deoxyuridine and 5-fluorouracil in the treatment of murine colon cancer; effects on thymidylate synthase.

G. Peters, Y. Rustum, C. L. van der Wilt, 1994, Advances in experimental medicine and biology.

Cross-resistance to thymidylate synthase inhibitors in P-glycoprotein and non-P-glycoprotein cell lines.

C. L. van der Wilt, B. van Triest, H. Pinedo, 1994, Advances in experimental medicine and biology.

In vitro antitumour activity of cis- and trans-5-fluoro-5,6-dihydro-6-alkoxy-uracils; effects on thymidylate synthesis.

G. Peters, C. L. van der Wilt, B. Braakhuis, 1993, British Journal of Cancer.

Development of a simple folylpolyglutamate synthetase assay in tissues and cell lines.

C. L. van der Wilt, J. Cloos, H. Pinedo, 1993, Advances in experimental medicine and biology.

Comparison of continuous infusions and bolus injections of 5-fluorouracil with or without leucovorin: implications for inhibition of thymidylate synthase.

C. L. van der Wilt, H. Pinedo, P. Noordhuis, 1993, Advances in experimental medicine and biology.

Biochemical modification of the toxicity and the anti-tumour effect of 5-fluorouracil and cis-platinum by WR-2721 in mice.

G. Peters, C. L. van der Wilt, K. Smid, 1992, European journal of cancer.

Effect of leucovorin on 5-fluorouracil induced inhibition of thymidylate synthase in patients with colon cancer.

S. Meijer, C. L. van der Wilt, H. Pinedo, 1991, Advances in experimental medicine and biology.

Expression of deoxycytidine kinase in leukaemic cells compared with solid tumour cell lines, liver metastases and normal liver.

G. Peters, M. Rots, C. L. van der Wilt, 2003, European journal of cancer.

Efficacy and advantages in the use of low doses of anandron and estrogen combination in the treatment of prostate cancer

A. Geldof, C. L. van der Wilt, H. de Voogt, 1988, The Prostate.

Evaluation of immunohistochemical staining and activity of thymidylate synthase in cell lines.

G. Peters, G. Aherne, C. L. van der Wilt, 1993, Advances in experimental medicine and biology.

5-Ethyl-2′-deoxyuridine, a modulator of both antitumour action and pharmacokinetics of 5-fluorouracil

G. Peters, P. Kovacs, C. L. van der Wilt, 1999, Journal of Cancer Research and Clinical Oncology.

The effect of different routes of administration of 5-fluorouracil on thymidylate synthase inhibition in the rat.

G. Peters, C. V. D. van de Velde, C. L. van der Wilt, 1995, European journal of cancer.

Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase.

C. L. van der Wilt, C. V. van Groeningen, G. Peters, 1994, European journal of cancer.

Detection of an alternatively spliced form of deoxycytidine kinase mRNA in the 2'-2'-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000.

G. Peters, I. Talianidis, C. L. van der Wilt, 2004, Biochemical pharmacology.

The role of deoxycytidine kinase in gemcitabine cytotoxicity.

G. Peters, I. Talianidis, C. L. van der Wilt, 2000, Advances in experimental medicine and biology.

Quantification of 5-fluorouracil incorporation into RNA of human and murine tumors as measured with a sensitive gas chromatography-mass spectrometry assay.

C. L. van der Wilt, H. Pinedo, P. Noordhuis, 1995, Analytical biochemistry.

Biochemical mechanisms of interferon modulation of 5-fluorouracil activity in colon cancer cells.

G. Peters, G. Aherne, C. L. van der Wilt, 1997, European journal of cancer.

Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.

C. L. van der Wilt, D. Priest, G. Jansen, 2001, Cancer research.

Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism.

G. Peters, H. McLeod, E. Bloemena, 2002, Biochimica et biophysica acta.

Protection by WR-2721 of the toxicity induced by the combination of cisplatin and 5-fluorouracil.

C. L. van der Wilt, H. Pinedo, W. van der Vijgh, 1992, International journal of radiation oncology, biology, physics.

The influence of BIBW22BS, a dipyridamole derivative, on the antiproliferative effects of 5-fluorouracil, methotrexate and gemcitabine in vitro and in human tumour xenografts.

C. L. van der Wilt, H. Pinedo, N. Feller, 1995, European journal of cancer.

The multilayered postconfluent cell culture as a model for drug screening.

G. Giaccone, G. J. Peters, C. L. van der Wilt, 2000, Critical reviews in oncology/hematology.

The interval between methotrexate and leucovorin determines the efficacy of 5-fluorouracil modulation in vitro and in vivo.

G. Peters, C. L. van der Wilt, H. Pinedo, 1993, Advances in experimental medicine and biology.

Cross-resistance to antifolates in multidrug resistant cell lines with P-glycoprotein or multidrug resistance protein expression.

G. Peters, C. L. van der Wilt, G. Jansen, 1997, Biochemical pharmacology.

Potentiation of 5-fluorouracil induced inhibition of thymidylate synthase in human colon tumors by leucovorin is dose dependent.

S. Meijer, C. L. van der Wilt, H. Pinedo, 1993, Advances in experimental medicine and biology.

Effects of antifolates on the binding of 5-fluoro-2'-deoxyuridine monophosphate to thymidylate synthase.

G. Peters, C. L. van der Wilt, K. Smid, 2002, Biochemical pharmacology.

18F-radiopharmacokinetics of [18F]-5-fluorouracil in a mouse bearing two colon tumors with a different 5-fluorouracil sensitivity: a study for a correlation with oncological results.

G. Peters, C. L. van der Wilt, G. Visser, 1996, Nuclear medicine and biology.

First results of triple‐modality treatment combining radiotherapy, chemotherapy, and hyperthermia for the treatment of patients with Stage IIB, III, and IVA cervical carcinoma

J. van der Zee, P. Koper, L. Prosnitz, 2005, Cancer.

Development, characterization and application of an antibody against 5-fluoro-2'deoxy-5'monophosphate, the active metabolite of 5-fluorouracil

J. de Vente, J. Vente, C. L. van der Wilt, 1993 .

Effect of folate diastereoisomers on the binding of 5-fluoro-2'-deoxyuridine-5'-monophosphate to thymidylate synthase.

G. Peters, C. L. van der Wilt, H. Pinedo, 1993, Biochemical pharmacology.

Combination studies of antifolates with 5-fluorouracil in colon cancer cell lines.

G. Peters, C. L. van der Wilt, C. Kuiper, 1999, Oncology Research.

Screening of colon tumor cells and tissues for folylpolyglutamate synthetase activity.

G. Peters, C. L. van der Wilt, J. Cloos, 1995, Oncology research.

Selective cell kill of the combination of gemcitabine and cisplatin in multilayered postconfluent tumor cell cultures.

G. Peters, C. L. van der Wilt, A. Bergman, 1999, Anti-cancer drugs.