S. Zabludoff

发表

DNA Damage Detection and Repair Pathways—Recent Advances with Inhibitors of Checkpoint Kinases in Cancer Therapy

S. Ashwell, S. Zabludoff, 2008, Clinical Cancer Research.

Identification of compounds with nanomolar binding affinity for checkpoint kinase-1 using knowledge-based virtual screening.

J. Wendoloski, P. Lyne, S. Ashwell, 2004, Journal of medicinal chemistry.

Inhibitors of checkpoint kinases: from discovery to the clinic.

P. Lyne, J. Janetka, S. Ashwell, 2007, Current opinion in drug discovery & development.

Anti-HSP47 siRNA lipid nanoparticle ND-L02-s0201 reverses interstitial pulmonary fibrosis in preclinical rat models

S. Zabludoff, J. Clamme, Yun Liu, 2021, ERJ Open Research.

Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors.

V. Oza, P. Lyne, J. Janetka, 2008, Bioorganic & medicinal chemistry letters.

In Vitro and In Vivo Radiation Sensitization of Human Tumor Cells by a Novel Checkpoint Kinase Inhibitor

James B. Mitchell, D. Citrin, W. Degraff, 2009 .

Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase

Y. Pommier, G. Schwartz, S. Zabludoff, 2010, Cell cycle.

Anti–miR-21 Suppresses Hepatocellular Carcinoma Growth via Broad Transcriptional Network Deregulation

R. Baffa, A. Pavlícek, Sung‐Min Ahn, 2015, Molecular Cancer Research.

Abstract 3919: Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition

T. Lawrence, J. Maybaum, S. Zabludoff, 2011 .

Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors

E. Sausville, P. LoRusso, M. Carducci, 2014, Cancer Chemotherapy and Pharmacology.

Cloning of mid-G1 serum response genes and identification of a subset regulated by conditional myc expression.

B. Wold, S. Tavtigian, S. Zabludoff, 1994, Molecular biology of the cell.

Germ cell-Sertoli cell interactions: the effect of testicular maturation on the synthesis of cyclic protein-2 by rat Sertoli cells.

S. Zabludoff, A. Karzai, W. Wright, 1990, Biology of reproduction.

Male germ cells regulate transcription of the cathepsin l gene by rat Sertoli cells.

S. Zabludoff, M. Charron, W. Wright, 2001, Endocrinology.

Cyclic protein-2, a secretory product of rat Sertoli cells, is the proenzyme form of cathepsin L.

S. Zabludoff, W. Wright, M. Erickson-Lawrence, 1991, Molecular endocrinology.

Sertoli cells, proximal convoluted tubules in the kidney, and neurons in the brain contain cyclic protein-2.

S. Zabludoff, W. Wright, M. Erickson-Lawrence, 1990, Biology of reproduction.

Dissociation of gemcitabine chemosensitization by CHK1 inhibition from cell cycle checkpoint abrogation and aberrant mitotic entry

Daria M. Tanska, T. Lawrence, J. Maybaum, 2016, Cell cycle.

Total syntheses of bengamides B and E.

M. Green, S. Zabludoff, K. Bair, 2001, The Journal of organic chemistry.

Germ cell-Sertoli cell interactions: regulation by germ cells of the stage-specific expression of CP-2/cathepsin L mRNA by Sertoli cells.

S. Zabludoff, T. Penttilä, W. Wright, 1995, Developmental genetics.

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway.

D. Livingston, H. Naegeli, A. Kung, 2004, Cancer cell.

Anti-miR182 Reduces Ovarian Cancer Burden, Invasion, and Metastasis: An In Vivo Study in Orthotopic Xenografts of Nude Mice

Zhaojian Liu, S. Zabludoff, Jian-jun Wei, 2014, Molecular Cancer Therapeutics.

BRCA1 mRNA is expressed highly during meiosis and spermiogenesis but not during mitosis of male germ cells.

B. Wold, K. Harshman, S. Zabludoff, 1996, Oncogene.

miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells.

A. Rashid, R. Kalluri, L. Beretta, 2015, Cancer research.

Lipid Nanoparticle–Mediated Delivery of Anti-miR-17 Family Oligonucleotide Suppresses Hepatocellular Carcinoma Growth

Jill Magnus, A. Pavlícek, V. Kaimal, 2017, Molecular Cancer Therapeutics.

p27Kip1 is expressed transiently in developing myotomes and enhances myogenesis.

B. Wold, M. Csete, S. Zabludoff, 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies

Stephen Green, B. Caleb, G. Schwartz, 2008, Molecular Cancer Therapeutics.

Shift of microRNA profile upon glioma cell migration using patient-derived spheroids and serum-free conditions

F. Poulsen, B. Kristensen, V. Kaimal, 2017, Journal of Neuro-Oncology.

Discovery of checkpoint kinase inhibitor (S)-5-(3-fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by structure-based design and optimization of thiophenecarboxamide ureas.

J. Breed, V. Oza, P. Lyne, 2012, Journal of medicinal chemistry.

Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition.

T. Lawrence, J. Maybaum, S. Zabludoff, 2011, Neoplasia.

Histone Deacetylase Inhibition Selectively Alters the Activity and Expression of Cell Cycle Proteins Leading to Specific Chromatin Acetylation and Antiproliferative Effects*

D. Cohen, S. Zabludoff, P. Kwon, 1999, The Journal of Biological Chemistry.

Proteomics-based Target Identification

Sunkyu Kim, Hans Voshol, J. Decaprio, 2003, Journal of Biological Chemistry.

Assessment of Chk1 Phosphorylation as a Pharmacodynamic Biomarker of Chk1 Inhibition

Daria M. Tanska, T. Lawrence, J. Maybaum, 2011, Clinical Cancer Research.

Anti-miR-17 therapy delays tumorigenesis in MYC-driven hepatocellular carcinoma (HCC)

D. Felsher, R. Dhanasekaran, V. Kaimal, 2017, Oncotarget.

In vitro and In vivo Radiation Sensitization of Human Tumor Cells by a Novel Checkpoint Kinase Inhibitor, AZD7762

James B. Mitchell, Kristin M. Fabre, D. Citrin, 2010, Clinical Cancer Research.

Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

Jonathan Maybaum, Diane M Simeone, Theodore S Lawrence, 2010, Cancer research.

MAP1D, a novel methionine aminopeptidase family member is overexpressed in colon cancer

N. Nirmala, H. Towbin, S. Zabludoff, 2006, Oncogene.

Keeping checkpoint kinases in line: new selective inhibitors in clinical trials.

J. Janetka, S. Ashwell, S. Zabludoff, 2008, Expert opinion on investigational drugs.

Synthesis and antitumor activity of ester-modified analogues of bengamide B.

S. Zabludoff, K. Bair, P. Crews, 2001, Journal of medicinal chemistry.

Germ Cell‐Sertoli Cell Interactions Studies of Cyclic Protein‐2 in the Seminiferous Tubule a

S. Zabludoff, A. Karzai, W. Wright, 1989, Annals of the New York Academy of Sciences.

Mice Study in Orthotopic Xenografts of Nude In Vivo Metastasis : An Reduces Ovarian Cancer Burden , Invasion , and miR

Zhaojian Liu, S. Zabludoff, Jian-jun Wei, 2014 .

Identification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cells

Madelyn Light, Q. Gao, D. Wiederschain, 2014, Nucleic acids research.

Preclinical pharmacokinetic/pharmacodynamic models to predict synergistic effects of co-administered anti-cancer agents

Gary K. Schwartz, Mithat Gönen, Demetri T. Moustakas, 2010, Cancer Chemotherapy and Pharmacology.

Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors.

Jon Read, Mei Su, J. Breed, 2012, Bioorganic & medicinal chemistry letters.

Discovery of a novel class of triazolones as checkpoint kinase inhibitors--hit to lead exploration.

J. Breed, V. Oza, P. Lyne, 2010, Bioorganic & medicinal chemistry letters.

Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

T. Lawrence, C. Canman, J. Maybaum, 2010, Cancer research.

AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies

B. Caleb, G. Schwartz, J. Janetka, 2008, Molecular Cancer Therapeutics.

miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells.

A. Rashid, R. Kalluri, L. Beretta, 2015, Cancer research.

Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors.

P. Lyne, J. Janetka, S. Ashwell, 2008, Bioorganic & medicinal chemistry letters.

Abstract 5917: A novel lipid nanoparticle (NBF-006) encapsulating glutathione S-transferase P (GSTP) siRNA for the treatment of KRAS-driven non-small cell lung cancer

J. Harborth, S. Zabludoff, J. Clamme, 2018 .