J. Le Pecq

C. Paoletti, J. Le Pecq, H. Garnier, 1980, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Recognition by the DNA repair system of DNA structural alterations induced by reversible drug-DNA interactions.

B. Roques, E. Ségal-Bendirdjian, J. Le Pecq, 1990, Anti-cancer drug design.

Selective alteration of mitochondrial function by Ditercalinium (NSC 335153), a DNA bisintercalating agent.

S. Brown, B. Roques, E. Ségal-Bendirdjian, 1990, Biochemical pharmacology.

The noncovalent complex between DNA and the bifunctional intercalator ditercalinium is a substrate for the UvrABC endonuclease of Escherichia coli.

B. Roques, J. Le Pecq, A. Yeung, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Selective loss of mitochondrial DNA after treatment of cells with ditercalinium (NSC 335153), an antitumor bis-intercalating agent.

B. Roques, E. Ségal-Bendirdjian, J. Le Pecq, 1988, Cancer research.

Asymmetrical bisintercalators as potential antitumor agents.

B. Roques, J. Le Pecq, B. Lambert, 1988, Journal of medicinal chemistry.

Geometry of the antitumor drug ditercalinium bisintercalated into d(CpGpCpG)2 by 1H NMR.

M. Delepierre, B. Roques, J. Le Pecq, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis of 11H-pyridocarbazoles and derivatives. Comparison of their DNA binding and antitumor activity with those of 6H- and 7H-pyridocarbazoles.

B. Roques, J. Markovits, J. Le Pecq, 1986, Journal of medicinal chemistry.

Cytoplasmic accumulation of ditercalinium in rat hepatocytes and induction of mitochondrial damage.

B. Roques, R. Fellous, E. Delain, 1988, Cancer research.

Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial

Olivier Lantz, Laurence Zitvogel, Sebastian Amigorena, 2005, Journal of Translational Medicine.

An analysis of variability in the manufacturing of dexosomes: implications for development of an autologous therapy.

J. Le Pecq, Sanjay Patel, H. Shu, 2005, Biotechnology and bioengineering.

Production and characterization of clinical grade exosomes derived from dendritic cells.

J. Le Pecq, Henry G Lamparski, Anita Metha-Damani, 2002, Journal of immunological methods.

Use of ethidium bromide for separation and determination of nucleic acids of various conformational forms and measurement of their associated enzymes.

J. Le Pecq, 1971, Methods of biochemical analysis.

Synthesis and binding properties to DNA and to opioid receptors of enkephalin-ellipticinium conjugates.

B. Roques, A. Jacquemin-Sablon, J. Le Pecq, 2009, International journal of peptide and protein research.

Mode of interaction and apparent binding constants of meso-tetraaryl porphyrins bearing between one and four positive charges with DNA.

D. Mansuy, J. Le Pecq, J. Battioni, 1986, Biochemical and biophysical research communications.

Effects of the bifunctional antitumor intercalator ditercalinium on DNA in mouse leukemia L1210 cells and DNA topoisomerase II.

K. Kohn, Y. Pommier, B. Roques, 1986, Cancer research.

Binding of bifunctional ethidium intercalators to transfer RNA.

B. Roques, J. Le Pecq, C. Reinhardt, 1982, Biochemical and biophysical research communications.

Inhibition of tRNA aminoacylation by ethidium dimer and several other bifunctional intercalators with or without antitumor activity.

P. Dessen, B. Roques, J. Markovits, 1981, Biochemical pharmacology.

Ethidium dimer: a new reagent for the fluorimetric determination of nucleic acids.

B. Roques, J. Markovits, J. Le Pecq, 1979, Analytical biochemistry.

PMR studies of the self-association of DNA intercalating ellipticine derivatives in aqueous solution.

B. Roques, J. Le Pecq, J. Lallemand, 1976, Biophysical chemistry.

DNA tris-intercalation: first acridine trimer with DNA affinity in the range of DNA regulatory proteins. Kinetic studies.

B. Roques, J. Markovits, J. Le Pecq, 1985, Biochemistry.

Another link between phospholipid transmembrane migration and ABC transporter gene family, inferred from a rare inherited disorder of phosphatidylserine externalization.

J. Mandel, J. Le Pecq, J. Freyssinet, 1997, Biochemical and biophysical research communications.

DNA polyintercalation: comparison of DNA binding properties of an acridine dimer and trimer

B. Roques, J. Markovits, B. Gaugain, 1984, FEBS letters.

DNA intercalating compounds as potential antitumor agents. 1. Preparation and properties of 7H-pyridocarbazoles.

B. Roques, R. Oberlin, J. Le Pecq, 1980, Journal of medicinal chemistry.

A new fluorometric method for RNA and DNA determination.

C. Paoletti, J. Le Pecq, J. L. Pecq, 1966, Analytical biochemistry.

Betulinic acid derivatives: a new class of human immunodeficiency virus type 1 specific inhibitors with a new mode of action.

I. Morize, E. De Clercq, R. Pauwels, 1996, Journal of medicinal chemistry.

DNA polyintercalating drugs. Proton magnetic resonance studies of a new acridine dimer. Conformations and interactions with mono- and dinucleotides.

B. Roques, J. Barbet, J. Le Pecq, 1976, Biochemistry.

Structure determination of the adduct formed between the signal nucleotide diadenosine 5′, 5‴‐P1, P4‐tetraphosphate (Ap4A) and cis‐[Pt(NH3)2Cl2]

J. Le Pecq, J. Girault, E. Segal, 1984, Biopolymers.

DNA intercalating compounds as potential antitumor agents. 2. Preparation and properties of 7H-pyridocarbazole dimers.

B. Roques, J. Le Pecq, D. Pélaprat, 1980, Journal of medicinal chemistry.

Effect of mutation, electric membrane potential, and metabolic inhibitors on the accessibility of nucleic acids to ethidium bromide in Escherichia coli cells.

J. Le Pecq, B. Lambert, 1984, Biochemistry.

Acridine dimers: influence of the intercalating ring and of the linking-chain nature on the equilibrium and kinetic DNA-binding parameters.

B. Roques, J. Markovits, J. Le Pecq, 1989, European journal of biochemistry.

Escherichia coli RNA-polymerase binding sites on DNA are only 14 base pairs long and are located between sequences that are very rich in AplusT.

P. Giacomoni, J. Le Pecq, J. L. Le Talaer, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Betulinic acid derivatives: a new class of specific inhibitors of human immunodeficiency virus type 1 entry.

E. De Clercq, R. Pauwels, J. Le Pecq, 1996, Journal of medicinal chemistry.

Deoxyribonucleic acid bifunctional intercalators: kinetic investigation of the binding of several acridine dimers to deoxyribonucleic acid.

P. Dessen, B. Roques, J. Barbet, 1979, Biochemistry.

DNA polyintercalating drugs: DNA binding of diacridine derivatives.

M Le Bret, B. Roques, J. Barbet, 1975, Proceedings of the National Academy of Sciences of the United States of America.

Comparative binding of ethidium and three azido analogs to dinucleotides: affinity and intercalation geometry. A 1H NMR and visible spectroscopy study.

B. Roques, J. Le Pecq, A. Delbarre, 1983, European journal of biochemistry.

Initial degradation of deoxyribonucleic acid after injection in mammals.

C. Paoletti, J. Le Pecq, P. Defrance, 1965, Cancer research.

Hydrogen bonding in deoxyribonucleic acid base recognition. 2. Deoxyribonucleic acid binding studies of acridine alkylamides.

B. Roques, J. Markovits, B. Gaugain, 1981, Biochemistry.

Antitumor activity of 9-hydroxyellipticine (NSC 210717) ON L1210 mouse leukemia and the effect of route of injection.

C. Paoletti, J. Le Pecq, S. Cros, 1976, Cancer research.

Effect of membrane potential on the cellular uptake of 2-N-methyl-ellipticinium by L1210 cells.

A. Jacquemin-Sablon, J. Le Pecq, J. Charcosset, 1984, Biochemical pharmacology.

A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer

J. Le Pecq, H. Lyerly, M. Morse, 2005, Journal of Translational Medicine.

Properties of immunotoxins against a glycolipid antigen associated with Burkitt's lymphoma.

T. Tursz, J. Le Pecq, J. Wiels, 1984, Cancer research.

Relationship between cellular diadenosine 5',5'''-P1,P4-tetraphosphate level, cell density, cell growth stimulation and toxic stresses.

J. Le Pecq, E. Segal, 1986, Experimental Cell Research.

Antitumor activity against L1210 mouse leukemia of immunotoxins containing a monoclonal antibody to the glycolipid globotriaosylceramide.

T. Tursz, J. Le Pecq, J. Wiels, 1987, Immunology letters.

Measurement of the expected DNA lengthening caused by mono‐ and bisintercalating drugs using electron microscopy

B. Roques, E. Delain, J. Barbet, 1978, Biopolymers.

DNase I susceptibility of bent DNA and its alteration by ditercalinium and distamycin.

J. Markovits, J. Le Pecq, J. Jaffrézou, 1990, Biochemistry.

Preliminary trial of 9-hydroxy-2-methyl ellipticinium (NSC 264--137) in advanced human cancers.

C. Paoletti, J. Le Pecq, A. Tanguy, 1978, European journal of cancer.

Cytotoxicity and SOS-inducing ability of ethidium and photoactivable analogs on E. coli ethidium-bromide-sensitive (Ebs) strains.

B. Roques, J. Le Pecq, B. Lambert, 1986, Mutation research.

Kinetic analysis of choriocarcinoma cell intoxication induced by ricin and ricin A chain immunotoxin.

M. Lipinski, T. Tursz, J. Le Pecq, 1988, Cancer research.

Synthesis and biological activity of new dimers in the 7H-pyrido[4,3-c] carbazole antitumor series.

B. Roques, A. Jacquemin-Sablon, J. Le Pecq, 1992, Journal of medicinal chemistry.

Electron microscopy analysis of the interaction between Escherichia coli DNA-dependent RNA polymerase and the replicative form of phage fd DNA. 2. Analysis of the dissociation kinetics.

P. Giacomoni, E. Delain, J. Le Pecq, 1977, European journal of biochemistry.

Exosomes as a Tumor Vaccine: Enhancing Potency Through Direct Loading of Antigenic Peptides

P. Paz, L. Zitvogel, J. Le Pecq, 2003, Journal of immunotherapy.

1H NMR study of the structure of a pyridocarbazole dimer-d[CpGpCpG] complex.

M. Delepierre, B. Roques, J. Le Pecq, 1985, Biochimie.

Interaction of DNA intercalator 3-nitrobenzothiazolo (3,2-a)quinolinium with DNA topoisomerases: a possible-mechanism for its biological activity.

G. Riou, J. Le Pecq, J. Riou, 1990, Molecular pharmacology.

Decay of fluorescence emission anisotropy of the ethidium bromide-DNA complex. Evidence for an internal motion in DNA.

J. Le Pecq, P. Wahl, J. Paoletti, 1970, Proceedings of the National Academy of Sciences of the United States of America.

Effect of 50 S subunit proteins L5, L18 and L25 on the fluorescence of 5 S RNA-bound ethidium bromide.

R. Garrett, J. Le Pecq, M. Le Bret, 1975, Journal of molecular biology.

The change of the torsion of the DNA helix caused by intercalation. I. A discussion of the two different possibilities, winding or unwinding.

J. Le Pecq, J. Paoletti, 1971, Biochimie.

A spectrofluorometric method for the study of transcription of single-stranded DNA by RNA polymerase.

C. Paoletti, J. Le Pecq, P. Jeanteur, 1966, Biochimica et biophysica acta.

Exosomes as novel therapeutic nanodevices.

J. Le Pecq, A. Delcayre, 2006, Current opinion in molecular therapeutics.

Mechanistic studies of a novel antitumor drug, alpha-1,3,5-triglycidyl-s-triazinetrione. Antitumor and cytotoxic effects.

J. Le Pecq, F. Wu, 1983, Molecular pharmacology.

Structure-activity relationships in a series of 5-[(2,5-dihydroxybenzyl)amino]salicylate inhibitors of EGF-receptor-associated tyrosine kinase: importance of additional hydrophobic aromatic interactions.

B. Roques, B. Tocqué, J. Le Pecq, 1994, Journal of medicinal chemistry.

Rational design of bis-intercalating drugs as antitumour agents: importance of rigidity in the linking chain.

M. Delepierre, B. Roques, J. Le Pecq, 1987, Drugs under experimental and clinical research.

A reexamination of the problem of resonance energy transfer between DNA intercalated chromophores using bisintercalating compounds.

B. Roques, J. Barbet, J. Le Pecq, 1977, Nucleic acids research.

Removal of DNA curving by DNA ligands: gel electrophoresis study.

B. Roques, J. Le Pecq, F. Barceló, 1991, Biochemistry.

Metabolism and disposition studies of 9-hydroxyellipticine and 2-methyl-9-hydroxyellipticinium acetate in animals.

C. Paoletti, J. Le Pecq, A. Gouyette, 1980, Cancer treatment reports.

A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer

J. Le Pecq, H. Lyerly, J. Garst, 2005, Journal of Translational Medicine.

Use of Ethidium Bromide for Separation and Determination of Nucleic Acids of Various Conformational Forms and Measurement of Their Associated Enzymes

J. Le Pecq, J. L. Pecq, J. B. Le Pecq, 1971 .

Cationic porphyrin-DNA interactions: importance of the number and position of the charges.

D. Mansuy, J. Le Pecq, D. Dupré, 1988, Biochemical pharmacology.