Chuan He

发表

Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA

Nian Liu, Tao Pan, Marc Parisien, 2013, RNA.

Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome

G. Hon, Yin Shen, P. Jin, 2012, Cell.

A silver-catalyzed intramolecular amidation of saturated C--h bonds.

Chuan He, Yong Cui, 2004, Angewandte Chemie.

Silver-catalyzed intermolecular amination of C--H groups.

Zigang Li, Chuan He, D. A. Capretto, 2007, Angewandte Chemie.

Using the bias from flow to elucidate single DNA repair protein sliding and interactions with DNA.

N. Scherer, Xiaohui Qu, A. Dinner, 2009, Biophysical journal.

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation.

O. Abdel-Wahab, J. Zavadil, A. Melnick, 2011, Cancer cell.

Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine

P. Jin, Baicheng Zhang, Ye Fu, 2011, Nature Biotechnology.

Genome-wide Profiling of 5-Formylcytosine Reveals Its Roles in Epigenetic Priming

P. Jin, Hao Wu, Ye Fu, 2013, Cell.

Tet-assisted bisulfite sequencing of 5-hydroxymethylcytosine

Bing Ren, Peng Jin, Gary C Hon, 2012, Nature Protocols.

Gene expression regulation mediated through reversible m6A RNA methylation

Gideon Rechavi, Ye Fu, G. Rechavi, 2014, Nature Reviews Genetics.

Reversible RNA adenosine methylation in biological regulation.

Guifang Jia, Ye Fu, Chuan He, 2013, Trends in genetics : TIG.

Detection of 5‐Hydroxymethylcytosine in DNA by Transferring a Keto‐Glucose by Using T4 Phage β‐Glucosyltransferase

Cai-Guang Yang, Miao Yu, Chun-Xiao Song, 2011, Chembiochem : a European journal of chemical biology.

Detection of 5-hydroxymethylcytosine in a combined glycosylation restriction analysis (CGRA) using restriction enzyme Taq(α)I.

Miao Yu, Chun-Xiao Song, Qing Dai, 2011, Bioorganic & medicinal chemistry letters.

Highly sensitive and selective gold(I) recognition by a metalloregulator in Ralstonia metallidurans.

Erik C. Wasinger, Chuan He, Jenny V Lockard, 2009, Journal of the American Chemical Society.

Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA

Chengqi Yi, Xing Jian, Cai-Guang Yang, 2008, Nature.

Preparation and characterization of the native iron(II)-containing DNA repair AlkB protein directly from Escherichia coli.

Y. Mishina, Chuan He, Lin X. Chen, 2004, Journal of the American Chemical Society.

Synthesis of DNA oligos containing 2'-deoxy-2'-fluoro-D-arabinofuranosyl-5-carboxylcytosine as hTDG inhibitor.

Xingyu Lu, Qing Dai, Chuan He, 2012, Tetrahedron.

A fluorescent probe for rapid detection of hydrogen sulfide in blood plasma and brain tissues in mice

Hai‐Liang Zhu, X. Deng, Chuan He, 2012 .

Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2

Chuan He, James R. Hinshaw, R. Sanishvili, 2014, Proceedings of the National Academy of Sciences.

The Oxidation-sensing Regulator (MosR) Is a New Redox-dependent Transcription Factor in Mycobacterium tuberculosis*

Nan Zhang, Chuan He, M. Voskuil, 2012, The Journal of Biological Chemistry.

The tightly regulated copper window in yeast.

Chuan He, Fei Sun, S. Wegner, 2011, Chemical communications.

Aureusimines in Staphylococcus aureus Are Not Involved in Virulence

Chuan He, Fei Sun, T. Bae, 2010, PloS one.

Sprouts of RNA epigenetics

Ye Fu, Yun-Gui Yang, G. Zheng, 2013, RNA biology.

An exceptionally selective lead(II)-regulatory protein from Ralstonia metallidurans: development of a fluorescent lead(II) probe.

Chuan He, S. Taghavi, D. van der Lelie, 2005, Angewandte Chemie.

The auxiliary protein complex SaePQ activates the phosphatase activity of sensor kinase SaeS in the SaeRS two‐component system of Staphylococcus aureus

S. Peterson, Marcus B. Jones, Q. Ji, 2012, Molecular microbiology.

Silver‐Catalyzed Nitrene Transfer Reactions

Zigang Li, Chuan He, D. A. Capretto, 2010 .

Metal-binding properties of Hpn from Helicobacter pylori and implications for the therapeutic activity of bismuth

Chuan He, S. Wegner, Murat Sunbul, 2011 .

METTL14 is essential for β-cell survival and insulin secretion.

Chuan He, Decheng Ren, Honggang Ye, 2019, Biochimica et biophysica acta. Molecular basis of disease.

Kethoxal-assisted single-stranded DNA sequencing (KAS-seq) for capturing transcription dynamics and enhancer activity

Chuan He, Tong Wu, Ruitu Lyu, 2020 .

Pseudomonas aeruginosa OspR is an oxidative stress sensing regulator that affects pigment production, antibiotic resistance and dissemination during infection

T. Murray, Chuan He, L. Lan, 2010, Molecular microbiology.

Efficient gold-catalyzed hydroamination of 1,3-dienes.

Chuan He, Chad Brouwer, 2006, Angewandte Chemie.

Staphylococcus aureus CymR Is a New Thiol-based Oxidation-sensing Regulator of Stress Resistance and Oxidative Response*

X. Deng, Haihua Liang, Q. Ji, 2012, The Journal of Biological Chemistry.

Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila.

Daniela C. Zarnescu, P. Jin, D. Zarnescu, 2008, Nature chemical biology.

Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR

S. Peterson, X. Deng, Marcus B. Jones, 2013, Proceedings of the National Academy of Sciences of the United States of America.

Platinum(II)-catalyzed intramolecular cyclization of o-substituted aryl alkynes through sp3 C-H activation.

Zigang Li, Chuan He, Xing Jian, 2009, Angewandte Chemie.

A highly sensitive and genetically encoded fluorescent reporter for ratiometric monitoring of quinones in living cells.

B. Zhao, Q. Ji, Chuan He, 2013, Chemical communications.

Addition of heterocycles to electron deficient olefins and alkynes catalyzed by gold(III)

Zigang Li, Chuan He, Zhangjie Shi, 2005 .

Recent Advances in Silver-Catalyzed Nitrene, Carbene, and Silylene-Transfer Reactions

Zigang Li, Chuan He, 2006 .

Organocatalytic asymmetric direct C(sp3)-H functionalization of ethers: a highly efficient approach to chiral spiroethers.

Chuan He, Y. Tu, Fu‐Min Zhang, 2012, Angewandte Chemie.

Chapter 1 - Silver-Mediated Oxidation Reactions: Recent Advances and New Prospects

Zigang Li, Chuan He, D. A. Capretto, 2009 .

Gold ( I )-Catalyzed Synthesis of Dihydrobenzofurans from Aryl Allyl Ethers

Cai-Guang Yang, Chuan He, Zhangjie Shi, 2006 .

Gold(I)-Catalyzed Synthesis of Dihydrobenzofurans from Aryl Allyl Ethers

Cai-Guang Yang, Chuan He, Zhangjie Shi, 2006 .

Mechanisms of Brønsted Acid Catalyzed Additions of Phenols and Protected Amines to Olefins: A DFT Study

Chuan He, Siyu Ye, Zhi‐Xiang Yu, 2008 .

Binding of ReO4− with an engineered MoO42−-binding protein: towards a new approach in radiopharmaceutical applications

B. Aryal, Chuan He, P. Brugarolas, 2011, JBIC Journal of Biological Inorganic Chemistry.

UO₂²⁺ uptake by proteins: understanding the binding features of the super uranyl binding protein and design of a protein with higher affinity.

Q. Cui, Chuan He, S. Odoh, 2014, Journal of the American Chemical Society.

Engineering a uranyl-specific binding protein from NikR.

Chuan He, S. Wegner, M. Jensen, 2009, Angewandte Chemie.

Nucleic acid modifications with epigenetic significance.

Ye Fu, Chuan He, Ye Fu, 2012, Current opinion in chemical biology.

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

Yang Wang, Jianping Ding, Chun-Xiao Song, 2011, Science.

Blood-brain barrier permeable gold nanoparticles: an efficient delivery platform for enhanced malignant glioma therapy and imaging.

Yu Cheng, Yu Han, Xiaobing Fan, 2014, Small.

Preparation of DNA Containing 5‐Hydroxymethyl‐2′‐Deoxycytidine Modification Through Phosphoramidites with TBDMS as 5‐Hydroxymethyl Protecting Group

Qing Dai, Chuan He, 2011, Current protocols in nucleic acid chemistry.

The structure of the human AGT protein bound to DNA and its implications for damage detection.

P. Rice, Chuan He, E. Duguid, 2005, Journal of molecular biology.

Damage Detection and Base Flipping in Direct DNA Alkylation Repair

Cai-Guang Yang, Chuan He, Kristel Garcia, 2009, Chembiochem : a European journal of chemical biology.

Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development

Qing Dai, Chuan He, Azusa Inoue, 2011, Cell Research.

Emergence of chemical biology approaches to the RNAi/miRNA pathway.

P. Jin, Yujing Li, Chuan He, 2010, Chemistry & biology.

A small molecule enhances RNA interference and promotes microRNA processing

Z. Paroo, Junliang Zhang, P. Jin, 2008, Nature Biotechnology.

m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination

G. Ming, X. Zhuang, Yang I. Li, 2019, Neuron.

Structural insight into substrate preference for TET-mediated oxidation

Cheng Luo, Ze Li, Lulu Hu, 2015, Nature.

Potential functional roles of DNA demethylation intermediates.

Chun-Xiao Song, Chuan He, 2013, Trends in biochemical sciences.

Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing

G. Hon, P. Jin, B. Ren, 2013, Nature Communications.

Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning

Zhike Lu, Hailing Shi, X. Zhuang, 2018, Neuron.

Oxidative demethylation of 3‐methylthymine and 3‐methyluracil in single‐stranded DNA and RNA by mouse and human FTO

Chengqi Yi, Zhiqiang Zhou, Xing Jian, 2008, FEBS letters.

Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth.

Robert A. Egnatchik, R. Deberardinis, N. Seyfried, 2015, Cancer cell.

Efficient and quantitative high-throughput transfer RNA sequencing

Chengqi Yi, Tao Pan, Yidan Qin, 2015, Nature Methods.

Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis

F. Tang, Lu Wen, Min Wang, 2013, Nature Communications.

Structure determination of DNA methylation lesions N1-meA and N3-meC in duplex DNA using a cross-linked protein–DNA system

G. Zheng, Chuan He, C. Yi, 2010, Nucleic acids research.

Interaction of human and bacterial AlkB proteins with DNA as probed through chemical cross-linking studies.

Y. Mishina, Chuan He, Chih-Hui J Lee, 2004, Nucleic acids research.

How do DNA repair proteins locate potential base lesions? a chemical crosslinking method to investigate O6-alkylguanine-DNA alkyltransferases.

Y. Mishina, Chuan He, E. Duguid, 2003, Chemistry & biology.

A TET Homologue Protein from Coprinopsis cinerea (CcTET) That Biochemically Converts 5-Methylcytosine to 5-Hydroxymethylcytosine, 5-Formylcytosine, and 5-Carboxylcytosine

L. Aravind, L. Iyer, Ye Fu, 2014, Journal of the American Chemical Society.

5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging

Peng Jin, Xuekun Li, Hao Wu, 2011, Nature Neuroscience.

Genome-wide DNA hydroxymethylation changes are associated with neurodevelopmental genes in the developing human cerebellum.

Tao Wang, Peng Jin, Qian Pan, 2012, Human molecular genetics.

The discovery of mammalian RNA demethylases

Ye Fu, Yun-Gui Yang, G. Zheng, 2013 .

Oxidative dealkylation DNA repair mediated by the mononuclear non-heme iron AlkB proteins.

Y. Mishina, Chuan He, 2006, Journal of inorganic biochemistry.

Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus

Kunqian Yu, Hualiang Jiang, Chuan He, 2016, Nature Communications.

Sensitive and specific single-molecule sequencing of 5-hydroxymethylcytosine

Tyson A. Clark, S. Turner, J. Korlach, 2011, Nature Methods.

Subsets of Visceral Adipose Tissue Nuclei with Distinct Levels of 5-Hydroxymethylcytosine

Robert J. Schmitz, L. Ji, R. Schmitz, 2016, PloS one.

Heterologous expression and purification of Arabidopsis thaliana VIM1 protein: in vitro evidence for its inability to recognize hydroxymethylcytosine, a rare base in Arabidopsis DNA.

J. Dunn, Chun-Xiao Song, D. Kumaran, 2012, Protein expression and purification.

Selective capture of 5-hydroxymethylcytosine from genomic DNA.

P. Jin, Chun-Xiao Song, Yujing Li, 2012, Journal of visualized experiments : JoVE.

Nonenzymatic Labeling of 5‐Hydroxymethylcytosine in Nanopore Sequencing

Xingyu Lu, Chuan He, 2013, Chembiochem : a European journal of chemical biology.

The hunt for 5-hydroxymethylcytosine: the sixth base.

Chun-Xiao Song, Chuan He, 2011, Epigenomics.

The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA.

T. Pan, Ye Fu, Wen Zhang, 2010, Angewandte Chemie.

A Non-Heme Iron-Mediated Chemical Demethylation in DNA and RNA

Cai-Guang Yang, Chuan He, C. Yi, 2009 .

Selective recognition of metal ions by metalloregulatory proteins.

Chuan He, Peng Chen, 2008, Current opinion in chemical biology.

Structural insight into the oxidation‐sensing mechanism of the antibiotic resistance of regulator MexR

Cai-Guang Yang, Chuan He, C. Yi, 2010, EMBO reports.

The Pseudomonas aeruginosa multidrug efflux regulator MexR uses an oxidation-sensing mechanism

A. Dinner, Zigang Li, Chuan He, 2008, Proceedings of the National Academy of Sciences.

Targeting MgrA-mediated virulence regulation in Staphylococcus aureus.

C. Luan, X. Deng, Chun-Xiao Song, 2011, Chemistry & biology.

A proteomic approach to identification of plutonium-binding proteins in mammalian cells.

T. Paunesku, B. Aryal, G. Woloschak, 2012, Journal of proteomics.

Fto Plays an Oncogenic Role in Acute Myeloid Leukemia As a N6-Methyladenosine RNA Demethylase

R. Larson, X. Weng, Jianjun Chen, 2016 .

Spectroscopic insights into lead(II) coordination by the selective lead(II)-binding protein PbrR691.

Chuan He, D. van der Lelie, Jing Zhao, 2007, Journal of the American Chemical Society.

N 6-Methyladenosine Modification of LncRNA Pvt1 Governs Epidermal Stemness

Yanlei Ma, Chuan He, Xiaoyang Wu, 2020 .

Gold‐Catalyzed Additions to Alkenes: O‐Nucleophiles

Zigang Li, Chuan He, D. A. Capretto, 2012 .

Gold-Catalyzed Additions to Alkenes: N-Nucleophiles

Zigang Li, Chuan He, D. A. Capretto, 2012 .

ALKBH4-dependent demethylation of actin regulates actomyosin dynamics

M. Dong, Yue-He Ding, Ye Fu, 2013, Nature Communications.

N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation

Zhike Lu, Chuan He, Kai Chen, 2018, Nature Chemical Biology.

Transcriptome-wide reprogramming of N6-methyladenosine modification by the mouse microbiome

Hailing Shi, Chuan He, T. Pan, 2018, Cell Research.

Integrating 5-Hydroxymethylcytosine into the Epigenomic Landscape of Human Embryonic Stem Cells

B. Ren, P. Jin, Chuan He, 2011, PLoS genetics.