H. Fujiwara

T. Tanimoto, M. Ikeda, M. Kurimoto, 2000, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Concurrent enhancement of monocyte immunoregulatory properties and effector functions by recombinant interferon-gamma.

D. Tweardy, H. Fujiwara, J. Ellner, 1986, Cellular immunology.

B cell-mediated down-regulation of IFN-gamma and IL-12 production induced during anti-tumor immune responses in the tumor-bearing state.

S. Maruo, H. Fujiwara, T. Hamaoka, 1998, International immunology.

Do Structural Changes of T Cell Receptor Complex Occur in Tumor‐bearing State?

H. Fujiwara, T. Hamaoka, S. Noda, 1995, Japanese journal of cancer research : Gann.

Suppressive Effect of Ultraviolet‐B‐Irradiation of Epidermal Cells on the Induction of Contact Sensitivity

H. Fujiwara, T. Hamaoka, T. Tsuchida, 1986, Microbiology and immunology.

TCR-Restimulated , Activated T Cells TCR / CD 9-Costimulated , Naive T Cells and Protease Pathway in Apoptosis of Differential Involvement of a Fas-CPP 32-Like

H. Fujiwara, K. Okumura, H. Yagita, 1998 .

Reversible CD8 expression induced by common cytokine receptor γ chain-dependent cytokines in a cloned CD4+ Th1 cell line

Y. Yashiro‐Ohtani, W. Park, H. Fujiwara, 2002 .

A series of immune responses leading to the induction ofT cell IL-12/IL-18 responsiveness in patientswith relatively large tumor burdens

K. Okuno, H. Fujiwara, T. Kishida, 2002, Cancer Immunology, Immunotherapy.

Differential IL-12 responsiveness of T cells but not of NK cells from tumor-bearing mice in IL-12-responsive versus -unresponsive tumor models.

H. Fujiwara, P. Gao, T. Hamaoka, 2000, International immunology.

Instability of assembled T-cell receptor complex that is associated with rapid degradation of zeta chains in immature CD4+CD8+ thymocytes.

A. Weissman, H. Fujiwara, T. Hamaoka, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Induction of Mouse T Cell CCR5 A Mandatory Role for STAT4 in IL-12

H. Fujiwara, M. Iwasaki, T. Mukai, 2001 .

Requirement for distinct Janus kinases and STAT proteins in T cell proliferation versus IFN-gamma production following IL-12 stimulation.

W. Park, H. Fujiwara, H. Ahn, 1998, Journal of immunology.

Langerhans Cells Factor Inhibits IL-12 production of Mouse Granulocyte/Macrophage Colony-Stimulating

Koichiro Nakamura, H. Fujiwara, Y. Tada, 2000 .

B7.2-Ig fusion proteins enhance IL-4-dependent differentiation of tumor-sensitized CD8+ cytotoxic T lymphocyte precursors.

M. Kogo, H. Fujiwara, K. Dunussi-Joannopoulos, 2005, International immunology.

An in vitro model for cyclosporin A-induced interference of intrathymic clonal elimination

H. Fujiwara, T. Hamaoka, H. Matsubara, 1990, The Journal of experimental medicine.

Involvement of intrasinusoidal hemostasis in the development of concanavalin a–induced hepatic injury in mice

H. Fujiwara, H. Tsutsui, K. Kaneda, 1998, Hepatology.

Critical involvement of interferon γ in the pathogenesis of T‐cell activation‐associated hepatitis and regulatory mechanisms of interleukin‐6 for the manifestations of hepatitis

H. Fujiwara, M. Uno, K. Kaneda, 1996, Hepatology.

A novel vaccine delivery system using immunopotentiating fusogenic liposomes.

Koji Kariya-city Aichi-pref. Tanaka, Y. Tsutsumi, T. Mayumi, 1999, Biochemical and biophysical research communications.

Property of class I H-2 alloantigen-reactive Lyt-2+ helper T cell subset. Abrogation of its proliferative and IL-2-producing capacities by intravenous injection of class I H-2-disparate allogeneic cells.

H. Fujiwara, S. Sato, J. Shimizu, 1988, Journal of immunology.

CD28 co-stimulatory signals induce IL-2 receptor expression on antigen-stimulated virgin T cells by an IL-2-independent mechanism.

S. Maruo, H. Fujiwara, Y. Takahama, 1996, International immunology.

Differential effects of N-acetyl-l-cysteine on IL-2- vs IL-12-driven proliferation of a T cell clone: implications for distinct signalling pathways.

M. Nakahira, M. Kurimoto, N. Sugimoto, 2000, Cytokine.

Mechanisms for Recognition of Tumor Antigens and Mediation of Anti‐tumor Effect by Noncytolytic Lyt‐2+ T Cell Subset*1

H. Fujiwara, J. Shimizu, T. Hamaoka, 1988, Japanese journal of cancer research : Gann.

Differential production of Th1- and Th2-type chemokines by mouse Langerhans cells and splenic dendritic cells.

Koichiro Nakamura, H. Fujiwara, P. Gao, 2005, The Journal of investigative dermatology.

Induction of anti-allo-class I H-2 tolerance by inactivation of CD8+ helper T cells, and reversal of tolerance through introduction of third- party helper T cells

H. Fujiwara, S. Sato, T. Hamaoka, 1990, The Journal of experimental medicine.

Interleukin‐1 Production by Blood Monocytes and Bronchoalveolar Cells in Sarcoidosis

H. Fujiwara, H. Fujiwara, M. Kleinhenz, 1986, Annals of the New York Academy of Sciences.

Administration of recombinant interleukin 12 prevents outgrowth of tumor cells metastasizing spontaneously to lung and lymph nodes.

H. Fujiwara, S. Herrmann, X. Tai, 1995, Cancer research.

Phenotypically and functionally distinct T-cell subsets in anti-tumor responses.

H. Fujiwara, T. Hamaoka, 1987, Immunology today.

Thymic Stroma‐Derived T Cell Growth Factor (TSTGF): III. Its Ability to Promote T Cell Proliferation Without Stimulating Interleukin 2‐ or 4‐Dependent Autocrine Mechanism

S. Sakuma, H. Fujiwara, T. Hamaoka, 1990, Journal of leukocyte biology.

The role of anti-asialo GM1 antibody-sensitive cells in the implementation of tumor-specific T cell-mediated immunity in vivo.

H. Fujiwara, S. Sato, T. Hamaoka, 1986, Japanese journal of cancer research : Gann.

A Defect in Cell–to–cell Adhesion via Integrin–Fibronectin Interactions in a Highly Metastatic Tumor Cell Line

H. Fujiwara, O. Niwa, K. Sobue, 1997, Japanese journal of cancer research : Gann.

Thymic Stroma‐Derived T‐Cell Growth Factor (TSTGF): II. Biochemical and Functional Characterization

H. Fujiwara, S. Sato, T. Hamaoka, 1988, Journal of leukocyte biology.

Role of L3T4 Antigen in the Activation of Various Functions of Lyt‐1+2‐ T Cells against Vaccinia Virus

H. Fujiwara, S. Sato, T. Hamaoka, 1986, Microbiology and immunology.

Transforming growth factor-beta (TGF-beta)-mediated immunosuppression in the tumor-bearing state: enhanced production of TGF-beta and a progressive increase in TGF-beta susceptibility of anti-tumor CD4+ T cell function.

H. Fujiwara, T. Katagiri, T. Hamaoka, 1993, Japanese journal of cancer research : Gann.

Defective accessory function of monocytes in human immunodeficiency virus-related disease syndromes.

M. Lederman, H. Fujiwara, Z. Toossi, 1988, The Journal of laboratory and clinical medicine.

Dependence on IL-4 Production T Cells and + Mediation by Type 2 CD8 Administration of B7-Ig Fusion Proteins: Induction of Tumor Regression by

M. Kogo, H. Fujiwara, V. Ling, 2004 .

Enhanced production of IL-6 in tumor-bearing mice and determination of cells responsible for its augmented production.

H. Fujiwara, T. Hamaoka, Y. Takai, 1990, Journal of immunology.

Studies on macrophage-activating factor (MAF) in antitumor immune responses

H. Fujiwara, T. Hamaoka, T. Gotoh, 1987, Cancer Immunology, Immunotherapy.

The cellular and molecular basis of the Lyt‐1+2− T cell‐mediated tumor‐eradicating mechanism in vivo

H. Fujiwara, T. Hamaoka, 1986, BioEssays : news and reviews in molecular, cellular and developmental biology.

The mode of recognition of tumor antigens by noncytolytic-type antitumor T cells: Role of antigen-presenting cells and their surface class I and class II H-2 molecules

H. Fujiwara, T. Katagiri, J. Shimizu, 2004, Cancer Immunology, Immunotherapy.

Mediation of in vivo Tumor‐neutralizing Activity by Lyt‐2+ as Well as L3T4+ T Cell Subsets*1

H. Fujiwara, T. Hamaoka, Hiroshi Yamamoto, 1988, Japanese journal of cancer research : Gann.

Establishment of murine macrophage hybridoma clones capable of acquiring tumoricidal activity upon activation with recombinant interferon-γ and lipopolysaccharide

H. Fujiwara, T. Katagiri, T. Hamaoka, 2004, Journal of Cancer Research and Clinical Oncology.

The augmentation of tumor-specific immunity by virus help

M. Fukuzawa, H. Fujiwara, T. Hamaoka, 1986, Cancer Immunology, Immunotherapy.

InductionofAnti-Allo-Class IH-2 Toleranceby Inactivation ofCD8 + HelperT Cells,and Reversal ofTolerancethroughIntroductionofThird-Party

H. Fujiwara, T. Hamaoka, Soichiro Sato, 1990 .

Requirements of adherent cells for activating Lyt-1+2- T cells as well as for functioning as antitumor effectors activated by factor(s) from Lyt-1+2- T cells.

H. Fujiwara, T. Hamaoka, Y. Takai, 1986, Japanese journal of cancer research : Gann.

The development of dermatitis infiltrated by γδ T-cells in IL-7 transgenic mice

H. Fujiwara, T. Sakata, I. Hikita, 1993 .

Recovery of antitumor CD4+ T cell responsiveness, suppressed in the tumor-bearing state, by release from tumor burden

H. Fujiwara, T. Hamaoka, J. Zou, 2005, Journal of Cancer Research and Clinical Oncology.

Suppression of Anti‐tumor CD4+ T Cell Responsiveness in the Tumor‐bearing State and Its Recovery in in vitro Culture Free of Tumor Burden

H. Fujiwara, T. Hamaoka, J. Zou, 1993, Japanese journal of cancer research : Gann.

Particular types of tumor cells have the capacity to convert transforming growth factor beta from a latent to an active form.

H. Fujiwara, T. Hamaoka, S. Fujimoto, 1992, Cancer research.

The role of tumor-specific Lyt-1+2- T cells in eradicating tumor cells in vivo. I. Lyt-1+2- T cells do not necessarily require recruitment of host's cytotoxic T cell precursors for implementation of in vivo immunity.

M. Fukuzawa, H. Fujiwara, T. Hamaoka, 1984, Journal of immunology.

OV-HM, Meth A, or MCH-1-A1 tumor induced complete regression of CSA1M and OV-HM tumors but induced only a slight growth inhibition

Ogawa, Steven, H. Fujiwara, 2006 .

Molecular mechanisms underlying IFN-γ-mediated tumor growth inhibition induced during tumor growth inhibition induced during tumor immunotherapy with rIL-12

H. Fujiwara, S. Herrmann, X. Tai, 1996 .

Molecular mechanisms underlying IFN-gamma-mediated tumor growth inhibition induced during tumor immunotherapy with rIL-12.

H. Fujiwara, S. Herrmann, X. Tai, 1996, International immunology.

Tumor-bearing mice exhibit a progressive increase in tumor antigen-presenting cell function and a reciprocal decrease in tumor antigen-responsive CD4+ T cell activity.

H. Fujiwara, J. Shimizu, T. Hamaoka, 1992, Journal of immunology.

A critical role for IL-18 in the proliferation and activation of NK1.1+ CD3- cells.

M Tomura, X Y Zhou, S Maruo, 1998, Journal of immunology.

IFN-alpha acts on T-cell receptor-triggered human peripheral leukocytes to up-regulate CCR5 expression on CD4+ and CD8+ T cells.

H. Fujiwara, G. Shearer, T. Hamaoka, 2001, Journal of clinical immunology.

Regulatory functions of hapten-reactive helper and suppressor T lymphocytes. III. Amplification of a generation of tumor-specific killer T-lymphocyte activities by suppressor T-cell-depleted hapten- reactive T lymphocytes

H. Fujiwara, H. Yamamoto, T. Hamaoka, 1979, The Journal of experimental medicine.

Role of glycosaminoglycans in the regulation of T cell proliferation induced by thymic stroma-derived T cell growth factor.

Y. Kita, H. Fujiwara, S. Watanabe, 1991, Journal of Immunology.

Administration of IL-12 induces a CD3+ CD4- CD8- B220+ lymphoid population capable of eliciting cytolysis against Fas-positive tumor cells.

H. Fujiwara, Y. Murata, T. Hamaoka, 1997, Journal of immunology.

Direct stimulation of monocyte release of interleukin 1 by mycobacterial protein antigens.

H. Fujiwara, J. Ellner, R. Wallis, 1986, Journal of immunology.

Increased interleukin-1 production and monocyte suppressor cell activity associated with human tuberculosis.

H. Fujiwara, J. Ellner, R. Wallis, 1986, The American review of respiratory disease.

IL‐12‐induced tumor regression correlates with in situ activity of IFN‐γ produced by tumor‐infiltrating cells and its secondary induction of anti‐tumor pathways

H. Fujiwara, T. Hamaoka, J. Mu, 1997, Journal of leukocyte biology.

Antitumor and antimetastatic effects of interleukin 12

H. Fujiwara, T. Hamaoka, 1996, Cancer Chemotherapy and Pharmacology.

A mechanism underlying synergy between IL-12 and IFN-gamma-inducing factor in enhanced production of IFN-gamma.

H. Okamura, M. Kurimoto, S. Maruo, 1997, Journal of immunology.

A new norepinephrine transporter imaging agent for cardiac sympathetic nervous function imaging: radioiodinated (R)-N-methyl-3-(2-iodophenoxy)-3-phenylpropanamine.

H. Saji, H. Fujiwara, H. Kawashima, 2003, Nuclear medicine and biology.

Inhibition of Growth and Metastasis of Ovarian Carcinoma by Administering a Drug Capable of Interfering with Vascular Endothelial Growth Factor Activity

H. Fujiwara, O. Niwa, X. Tai, 1996, Japanese journal of cancer research : Gann.

Deleterious effect of ultraviolet-B radiation on accessory function of human blood adherent mononuclear cells.

C. Elmets, H. Fujiwara, J. Ellner, 1987, Clinical and experimental immunology.

The unique target specificity of a nonpeptide chemokine receptor antagonist: selective blockade of two Th1 chemokine receptors CCR5 and CXCR3

Y. Yashiro‐Ohtani, N. Sugimoto, H. Fujiwara, 2003, Journal of leukocyte biology.

Separation of the Tumor Rejection Antigen of Rous Sarcoma Virus‐induced Murine Fibrosarcoma

H. Fujiwara, J. Shimizu, T. Hamaoka, 1988, Japanese journal of cancer research : Gann.

Immunologic characterization of tumor-associated transplantation antigens on MM102 mammary tumor eliciting preferentially helper T cell activity.

H. Fujiwara, T. Hamaoka, T. Tsuchida, 1978, Journal of immunology.

Preferential generation of killer or helper T-lymphocyte activity directed to the tumour-associated transplantation antigens.

H. Fujiwara, T. Hamaoka, H. Aoki, 1976, Immunology.

Studies on the recovery from tolerance to tumor antigens

H. Fujiwara, T. Hamaoka, Soichiro Sato, 2004, Cancer Immunology, Immunotherapy.

Augmentation of antitumor immune response by trinitrophenyl (TNP)-reactive helper T-cells: enhanced induction of tumor-specific Lyt-1+2- T-cell-mediated delayed-type hypersensitivity from spleen cells of tumor-bearing mice by TNP helpers.

H. Fujiwara, G. Shearer, T. Hamaoka, 1986, Journal of the National Cancer Institute.

The Tumor Rejection Antigen Separated from Rous Sarcoma Virus‐induced Murine Fibrosarcoma Exhibits a Molecular Weight of Approximately 60 kD but Differs from Functional pp60src

Takato O. Yoshida, H. Fujiwara, J. Shimizu, 1989, Japanese journal of cancer research : Gann.

A Novel Function of Vα14+CD4+NKT Cells: Stimulation of IL-12 Production by Antigen-Presenting Cells in the Innate Immune System

H. Fujiwara, M. Taniguchi, T. Hamaoka, 1999, The Journal of Immunology.

A critical role for a peritumoral stromal reaction in the induction of T-cell migration responsible for interleukin-12-induced tumor regression.

H. Fujiwara, T. Hamaoka, T. Kubo, 1999, Cancer research.

Enhanced induction of tumor-specific Lyt-1+2- T cell-mediated protective immunity by in vivo administration of interleukin 1.

K. Okuno, H. Fujiwara, T. Hamaoka, 1985, Japanese journal of cancer research : Gann.

Selective expression of paternal human major histocompatibility antigens on the surface of hydatidiform mole cells.

H. Fujiwara, T. Hamaoka, T. Hirai, 1978, Gan.

REDISTRIBUTION OF CALDESMON AND TROPOMYOSIN ASSOCIATED WITH CONCANAVALIN A RECEPTOR CAPPING ON SPLENIC T-LYMPHOCYTES

H. Fujiwara, K. Sobue, T. Hamaoka, 1987 .

Cross-reactivity between haptenic muramyl di- or tripeptide derivatives and Mycobacterium bovis BCG: potential application for enhancing tumor immunity

H. Fujiwara, T. Kusama, T. Hamaoka, 1986, Infection and immunity.

Role of the thymus in repopulating alloantigen-reactive T cells after its functional elimination by intravenous presensitization with allogeneic cells.

H. Fujiwara, S. Sato, T. Hamaoka, 1991, Transplantation proceedings.

A role of interferon-gamma (IFN-gamma) in tumor immunity: T cells with the capacity to reject tumor cells are generated but fail to migrate to tumor sites in IFN-gamma-deficient mice.

H. Fujiwara, P. Gao, T. Hamaoka, 2001, Cancer research.

Constitutive Expression of Interleukin‐7 mRNA and Production of IL‐7 by a Cloned Murine Thymic Stromal Cell Line

S. Nishikawa, H. Fujiwara, Y. Tsuruta, 1990, Journal of leukocyte biology.

Type II collagen-induced murine arthritis: induction of arthritis depends on antigen-presenting cell function as well as susceptibility of host to an anticollagen immune response.

H. Fujiwara, T. Hamaoka, K. Orito, 1992, Journal of Immunology.

Tolerance Induction of Alloreactivity by Portal Venous Inoculation with Allogeneic Cells Followed by the Injection of Cyclophosphamide

H. Fujiwara, T. Hamaoka, J. Qian, 1988, Microbiology and immunology.

The mechanism of tolerance induction of tumor-specific delayed-type hypersensitivity responses by intravenous inoculation of tumor cells.

M. Fukuzawa, H. Fujiwara, S. Sato, 1985, Japanese journal of cancer research : Gann.

Enhanced TNP-reactive helper T cell activity and its utilization in the induction of amplified tumor immunity that results in tumor regression.

H. Fujiwara, G. Shearer, T. Hamaoka, 1984, Journal of immunology.

Helper cell analysis in cytotoxic T lymphocyte responses I. Activation of specific and cross‐reactive helper effects in two hapten‐modified self responses

H. Fujiwara, G. Shearer, R. Levy, 1980, European journal of immunology.

Non‐H‐2‐associated genetic regulation of cytotoxic responses to hapten‐modified syngeneic cells Effect on the magnitude of secondary response and helper T cell generation after in vivo priming

H. Fujiwara, G. Shearer, 1981, European journal of immunology.

Tolerance induction in tumor-specific effector T cells by presensitization with tumor antigens via the intragastric route.

K. Okuno, H. Fujiwara, T. Hamaoka, 1984, Gan.

The augmentation of tumor-specific immunity using haptenic muramyl dipeptide (MDP) derivatives

H. Fujiwara, T. Hamaoka, S. Sano, 1987, Cancer Immunology, Immunotherapy.

The augmentation of tumor-specific immunity using haptenic muramyl dipeptide (MDP) derivatives

H. Fujiwara, T. Kusama, T. Hamaoka, 2004, Cancer Immunology, Immunotherapy.

A non‐peptide CCR5 antagonist inhibits collagen‐induced arthritis by modulating T cell migration without affecting anti‐collagen T cell responses

H. Fujiwara, P. Gao, S. Obika, 2002, European journal of immunology.

Glycyrrhizin enhances interleukin‐12 production in peritoneal macrophages

H. Fujiwara, J. Dai, Y. Iwatani, 2001, Immunology.

Evidence for the functional binding in vivo of tumor rejection antigens to antigen-presenting cells in tumor-bearing hosts.

H. Fujiwara, T. Katagiri, J. Shimizu, 1991, Journal of immunology.

Response to IL-18 γ and Produce IFN-T Cell Subsets to Express IL-18 Receptor − CD 8 − , and CD 4 + , CD 8 + Differential Capacities of CD 4

H. Okamura, M. Kurimoto, S. Maruo, 1998 .

Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. II. Immunohistochemical studies on the thyroiditis lesion.

Y. Kohno, S. Maruo, H. Fujiwara, 1989, Regional immunology.

Sublobular veins as the main site of lymphocyte adhesion/transmigration and adhesion molecule expression in the porto‐sinusoidal‐hepatic venous system during concanavalin A–induced hepatitis in mice

H. Fujiwara, T. Kuroki, K. Kaneda, 2000, Hepatology.

The augmentation of tumor‐specific immunity by virus help. I. Demonstration of vaccinia virus‐reactive helper T cell activity involved in enhanced induction of cytotoxic T lymphocyte and antibody responses

H. Fujiwara, T. Hamaoka, Y. Takai, 1984, European journal of immunology.

Spontaneous production of a suppressor factor by a human macrophage-like cell line U937. II. Suppression of antigen- and mitogen-induced blastogenesis, IL 2 production and IL 2 receptor expression in T lymphocytes.

H. Fujiwara, Z. Toossi, J. Ellner, 1987, Journal of immunology.

Spontaneous production of a suppressor factor by the human macrophage-like cell line U937. I. Suppression of interleukin 1, interleukin 2, and mitogen-induced blastogenesis in mouse thymocytes.

H. Fujiwara, J. Ellner, 1986, Journal of immunology.

Cell-cell interaction in graft rejection responses: induction of anti- allo-class I H-2 tolerance is prevented by immune responses against allo-class II H-2 antigens coexpressed on tolerogen

H. Fujiwara, T. Hamaoka, K. Isono, 1992, The Journal of experimental medicine.

Enhanced production of interleukin-6 in mice with type II collagen-induced arthritis.

F. Lee, H. Fujiwara, T. Hamaoka, 1989, Arthritis and rheumatism.

The role of tumor-specific Lyt-1+2− T cells in eradicating tumor cells in vivo

H. Fujiwara, J. Shimizu, T. Hamaoka, 1987, Cancer Immunology, Immunotherapy.

Expression and regulation of RANTES/CCL5, MIP-1alpha/CCL3, and MIP-1beta/CCL4 in mouse Langerhans cells.

H. Fujiwara, P. Gao, H. Fujita, 2004, The Journal of investigative dermatology.

Enhanced induction of very late antigen 4/lymphocyte function-associated antigen 1-dependent T-cell migration to tumor sites following administration of interleukin 12.

H. Fujiwara, S. Herrmann, T. Hamaoka, 1997, Cancer research.

Coordination of chemokine and adhesion systems in intratumoral T cell migration responsible for the induction of tumor regression.

H. Fujiwara, T. Hamaoka, 2001, International immunopharmacology.

Mouse CD4 and CD8 T-cell clones that recognize xeno-antigens directly on xeno-antigen presenting cells in xeno MHC-restricted ways.

H. Fujiwara, T. Hamaoka, A. Onitsuka, 1997, Transplantation proceedings.

Additional evidence for the augmented induction of tumor-specific resistance in vaccinia virus-primed mice by immunization with vaccinia virus-modulated syngeneic tumor cells.

H. Fujiwara, T. Hamaoka, N. Wakamiya, 1984, Biken journal.

The augmentation of tumor‐specific immunity by virus help. II. Enhanced induction of cytotoxic T lymphocyte and antibody responses to tumor antigens by vaccinia virus‐reactive helper T cells

H. Fujiwara, T. Hamaoka, N. Wakamiya, 1984 .

The augmentation of tumor-specific immunity by virus help. III. Enhanced generation of tumor-specific Lyt-1+2- T cells is responsible for augmented tumor immunity in vivo.

M. Fukuzawa, H. Fujiwara, T. Hamaoka, 1986, Cancer immunology, immunotherapy : CII.

Studies on the induction of tolerance to alloantigens. II. The generation of serum factor(s) able to transfer alloantigen-specific tolerance for delayed-type hypersensitivity by portal venous inoculation with allogeneic cells.

H. Fujiwara, T. Hamaoka, S. Satoh, 1986, Journal of immunology.

Studies on the induction of tolerance to alloantigens. I. The abrogation of potentials for delayed-type-hypersensitivity response to alloantigens by portal venous inoculation with allogeneic cells.

H. Fujiwara, T. Hamaoka, T. Hashimoto, 1985, Journal of immunology.

T-T cell interaction in the induction of delayed-type hypersensitivity (DTH) responses: vaccinia virus-reactive helper T cell activity involved in enhanced in vivo induction of DTH responses and its application to augmentation of tumor-specific DTH responses.

H. Fujiwara, T. Hamaoka, A. Kosugi, 1985, Journal of immunology.

Multiple Roles of Interferon-γ in the Mediation of Interleukin 12-induced Tumor Regression

H. Fujiwara, T. Hamaoka, M. Iwasaki, 1998 .

The anti-tumor effects of IL-12 involve enhanced IFN-gamma production by anti-tumor T cells, their accumulation to tumor sites and in situ IFN-gamma production.

H. Fujiwara, T. Hamaoka, 1997, Leukemia.

Induction of tumor-specific in vivo protective immunity by immunization with tumor antigen-pulsed antigen-presenting cells.

H. Fujiwara, J. Shimizu, T. Hamaoka, 1989, Journal of immunology.

Multiple roles of interferon-gamma in the mediation of interleukin 12-induced tumor regression.

H. Fujiwara, T. Hamaoka, M. Iwasaki, 1998, Cancer research.

A pivotal role for CC chemokine receptor 5 in T-cell migration to tumor sites induced by interleukin 12 treatment in tumor-bearing mice.

K. Matsushima, Y. Kitamura, H. Fujiwara, 2002, Cancer research.

The augmentation of tumor-specific immunity using haptenic muramyl dipeptide (MDP) derivatives

H. Fujiwara, T. Hamaoka, T. Yoshioka, 2004, Cancer Immunology, Immunotherapy.

Immune Dysfunction Expressed Selectively on L3T4+ T Cells in the Tumor‐Bearing State

H. Fujiwara, T. Hamaoka, Soichiro Sato, 1990, Journal of leukocyte biology.

Demonstration of intratumoral infiltration of tumor-specific Lyt-1+2- T cells mediating delayed-type hypersensitivity response and in vivo protective immunity.

H. Fujiwara, T. Tsuchida, Y. Yamane, 1986, Japanese journal of cancer research : Gann.

Effector cell analysis of tumor cell rejection in vivo in two syngeneic tumor systems exhibiting distinct in vitro cytotoxic mechanisms.

M. Fukuzawa, H. Fujiwara, T. Hamaoka, 1984, Gan.

Differential interleukin 12 responsiveness for interferon gamma production in advanced stages of cancer patients correlates with performance status.

H. Fujiwara, T. Kishida, K. Uno, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

Murine tumor cell lysis by antibody-dependent macrophage-mediated cytotoxicity using syngeneic monoclonal antibodies.

I. Kawase, H. Fujiwara, T. Hamaoka, 1985, Cancer research.

Evidence of direct recognition subset in xeno-reactive helper T cells.

H. Fujiwara, T. Hamaoka, A. Onitsuka, 1996, Artificial organs.

A mechanism underlying STAT4-mediated up-regulation of IFN-gamma induction inTCR-triggered T cells.

Y. Yashiro‐Ohtani, M. Nakahira, N. Sugimoto, 2004, International immunology.

Requirement for IFN-γ in IL-12 production induced by collaboration between Vα14+ NKT cells and antigen-presenting cells

H. Fujiwara, T. Hamaoka, M. Tomura, 2000 .

Tumor Vaccination That Enhances Antitumor T-Cell Responses Does Not Inhibit the Growth of Established Tumors Even in Combination With Interleukin-12 Treatment: The Importance of Inducing Intratumoral T-Cell Migration

M. Nakahira, H. Fujiwara, P. Gao, 2000, Journal of immunotherapy.

Studies on the recovery from tolerance to tumor antigens

M. Fukuzawa, H. Fujiwara, T. Hamaoka, 1987, Cancer Immunology, Immunotherapy.

Induction of surface CCR4 and its functionality in mouse Th2 cells is regulated differently during Th2 development

M. Kogo, Y. Yashiro‐Ohtani, H. Fujiwara, 2005, Journal of leukocyte biology.

IL-12 as Well as IL-2 Upregulates CCR5 Expression on T Cell Receptor-Triggered Human CD4+ and CD8+ T Cells

H. Fujiwara, G. Shearer, P. Gao, 2001, Journal of Clinical Immunology.

Establishment of a tumor-specific immunotherapy model utilizing TNP-reactive helper T cell activity and its application to the autochthonous tumor system.

H. Fujiwara, T. Hamaoka, H. Aoki, 1984, Journal of Immunology.

Expression of an inducible type of nitric oxide (NO) synthase in the thymus and involvement of NO in deletion of TCR-stimulated double-positive thymocytes.

H. Fujiwara, K. Toyo-oka, X. Tai, 1997, Journal of immunology.

AUGMENTATION OF TUMOR-SPECIFIC IMMUNITY BY T-T CELL INTERACTION AND ITS APPLICATION TO TUMOR METASTASIS INHIBITION

K. Takatsu, H. Fujiwara, T. Hamaoka, 1982 .

Suppressive effect of portal venous inoculation with tumor cells on the anti-tumor immune potential.

H. Fujiwara, T. Hamaoka, S. Kokudo, 1987, Japanese journal of cancer research : Gann.

B cells regulate CD40 ligand-induced IL-12 production in antigen-presenting cells (APC) during T cell/APC interactions.

G. Trinchieri, S. Maruo, H. Fujiwara, 1997, Journal of immunology.

The development of dermatitis infiltrated by gamma delta T cells in IL-7 transgenic mice.

H. Fujiwara, T. Sakata, I. Hikita, 1993, International immunology.

Requirement for IFN-gamma in IL-12 production induced by collaboration between v(alpha)14(+) NKT cells and antigen-presenting cells.

H. Fujiwara, T. Hamaoka, M. Tomura, 2000, International immunology.

The development of peritumoral stroma required for IL-12 induced tumor regression depends on the T cell/IFN-gamma-involving host-tumor interaction.

H. Fujiwara, P. Gao, T. Hamaoka, 2000, International Journal of Oncology.

Association of a tetraspanin CD9 with CD5 on the T cell surface: role of particular transmembrane domains in the association.

Y. Yashiro‐Ohtani, H. Fujiwara, K. Miyake, 1999, International immunology.

IL‐12 plays a pivotal role in LFA‐1‐mediated T cell adhesiveness by up‐regulation of CCR5 expression

M. Kogo, Y. Yashiro‐Ohtani, M. Kurimoto, 2001, Journal of leukocyte biology.

Heterogenous graft rejection pathways in class I major histocompatibility complex-disparate combinations and their differential susceptibility to immunomodulation induced by intravenous presensitization with relevant alloantigens

H. Fujiwara, S. Sato, J. Shimizu, 1991, The Journal of experimental medicine.

Non-CD28 Costimulatory Molecules Present in T Cell Rafts Induce T Cell Costimulation by Enhancing the Association of TCR with Rafts1

Y. Yashiro‐Ohtani, H. Fujiwara, R. Abe, 2000, The Journal of Immunology.

The mechanism of tumor growth inhibition by tumor-specific Lyt-1+2-T cells. I. Antitumor effect of Lyt-1+2-T cells depends on the existence of adherent cells.

H. Fujiwara, T. Hamaoka, Y. Takai, 1985, Journal of immunology.

Induction of lectin-like oxidized LDL receptor by oxidized LDL and lysophosphatidylcholine in cultured endothelial cells.

T. Aoyama, T. Sawamura, H. Fujiwara, 1999, Journal of molecular and cellular cardiology.

Pre-B cells adhere to fibronectin via interactions of integrin α5/αv with RGDS as well as of integrin α4 with two distinct V region sequences at its different binding sites

H. Fujiwara, Y. Oka, H. Sugiyama, 1994 .

Capacities of a Newly Established Thymic Stromal Cell Clone to Express la Antigens and to Produce Interleukin‐6, Colony‐Stimulating Factor, and Thymic Stroma‐Derived T‐Cell Growth Factor

H. Fujiwara, T. Katagiri, K. Ishimura, 1989, Journal of leukocyte biology.

Proliferation and differentiation of immature thymocytes induced by a thymic stromal cell clone.

H. Fujiwara, T. Hamaoka, Y. Takai, 1990, Thymus.

Studies on macrophage-activating factor (MAF) in antitumor immune responses. I. Tumor-specific Lyt-1+2- T cells are required for producing MAF able to generate cytolytic as well as cytostatic macrophages.

H. Fujiwara, T. Hamaoka, T. Tsuchida, 1985, Journal of immunology.

Immunogenetic Analysis of Tolerance Induction in Anti‐Alloantigen Delayed Type Hypersensitivity Responses by Portal Venous Pre‐Inoculation with Allogeneic Cells

H. Fujiwara, J. Shimizu, T. Hamaoka, 1987, Microbiology and immunology.

Abrogation of the capacity of delayed-type hypersensitivity responses to alloantigens by intravenous injection of neuraminidase-treated allogeneic cells.

H. Fujiwara, S. Sato, T. Hamaoka, 1987, Journal of immunology.

Helper T cells against tumor-associated antigens (TAA): preferential induction of helper T cell activities involved in anti-TAA cytotoxic T lymphocyte and antibody responses.

H. Fujiwara, T. Hamaoka, K. Itoh, 1986, Journal of immunology.

TOLERANCE INDUCTION OF ALLOREACTIVITY BY PORTAL VENOUS INOCULATION WITH ALLOGENEIC CELLS FOLLOWED BY THE INJECTION OF CYCLOPHOSPHAMIDE: I. SPECIFIC SUPPRESSION OF ALLOREACTIVE CYTOTOXIC AND DELAYED‐TYPE HYPERSENSITIVITY RESPONSES AS WELL AS ALLOGRAFT REJECTION

H. Fujiwara, S. Sato, T. Hamaoka, 1987, Transplantation.

Suppression of allograft responses by combining alloantigen-specific i.v. pre-sensitization with suboptimal doses of rapamycin.

H. Fujiwara, K. Toyo-oka, T. Hamaoka, 1994, International immunology.

Opposite actions of transforming growth factor-beta 1 on the gene expression of atrial natriuretic peptide biological and clearance receptors in a murine thymic stromal cell line.

K. Matsumoto, H. Fujiwara, Yiqiang Cai, 1995, Journal of biochemistry.

The Activation of L3T4+ Helper T Cells Assisting the Generation of Anti‐Tumor Lyt‐2+ Cytotoxic T Lymphocytes: Requirement of 1a‐Positive Antigen‐Presenting Cells for Processing and Presentation of Tumor Antigens

H. Fujiwara, Y. Takahama, T. Hamaoka, 1987, Journal of Leukocyte Biology.

Suppression of Anti‐tumor CD4+ T Cell Responsiveness in the Tumor‐bearing State and Its Recovery in in vitro Culture Free of Tumor Burden

H. Fujiwara, T. Hamaoka, J. Zou, 1993, Japanese journal of cancer research : Gann.

Selective Suppression of the Generation of Anti‐tumor L3T4+ but Not of Lyt‐2+ T Cell‐mediated Immunity in the Tumor‐hearing State

H. Fujiwara, T. Hamaoka, Soichiro Sato, 1988, Japanese journal of cancer research : Gann.

A novel function of Valpha14+CD4+NKT cells: stimulation of IL-12 production by antigen-presenting cells in the innate immune system.

H. Fujiwara, M. Taniguchi, H. Ahn, 1999, Journal of immunology.