P. Tsichlis

P. Tsichlis, R. Muise-Helmericks, D. Corum, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Defective Activation of ERK in Macrophages Lacking the p50/p105 Subunit of NF-κB Is Responsible for Elevated Expression of IL-12 p40 Observed after Challenge with Helicobacter hepaticus1

M. Gadjeva, P. Tsichlis, J. Fox, 2006, The Journal of Immunology.

Defective Activation of ERK in Macrophages

M. Gadjeva, P. Tsichlis, J. Fox, 2005 .

Targeting phosphatidylinositol 3 kinase-β and -δ for Bruton tyrosine kinase resistance in diffuse large B-cell lymphoma.

P. Tsichlis, R. Baiocchi, L. Alinari, 2020, Blood advances.

The inhibition of KDM2B promotes the differentiation of basal-like breast cancer cells via the posttranslational destabilization of SLUG

P. Tsichlis, Evangelia D Chavdoula, M. Paraskevopoulou, 2020, bioRxiv.

Effects of hypoxia and hypercapnia on surfactant protein expression proliferation and apoptosis in A549 alveolar epithelial cells.

P. Tsichlis, C. Tsatsanis, D. Georgopoulos, 2005, Life sciences.

Concerted DNA rearrangements in Moloney murine leukemia virus-induced thymomas: a potential synergistic relationship in oncogenesis

P. Tsichlis, M. A. Lohse, P. Strauss, 1985, Journal of virology.

Genetic mapping of a cellular DNA region involved in induction of thymic lymphomas (Mlvi-1) to mouse chromosome 15

C. Kozak, P. Tsichlis, P. Strauss, 1985, Molecular and cellular biology.

Structure of a Moloney murine leukemia virus-virus-like 30 recombinant: implications for transduction of the c-Ha-ras proto-oncogene

P. Tsichlis, C. Patriotis, A. Makris, 1993, Journal of virology.

Proteinase-activated receptor-1-triggered activation of tumor progression locus-2 promotes actin cytoskeleton reorganization and cell migration.

P. Tsichlis, C. Polytarchou, M. Hatziapostolou, 2008, Cancer research.

TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway.

G. Kollias, K. Stamatakis, N. Copeland, 2000, Cell.

The proteins encoded by c-akt and v-akt differ in post-translational modification, subcellular localization and oncogenic potential.

J. Testa, T. Franke, P. Tsichlis, 1993, Oncogene.

RETRACTED ARTICLE: Phosphor-IWS1-dependent U2AF2 splicing regulates trafficking of CAR-E-positive intronless gene mRNAs and sensitivity to viral infection

V. Coppola, P. Tsichlis, C. Tsatsanis, 2021, Communications Biology.

Genetic ablation of interacting with Spt6 (Iws1) causes early embryonic lethality

K. L. La Perle, V. Coppola, P. Tsichlis, 2018, PloS one.

Abstract 108: FGF-2 regulates cell proliferation, migration and angiogenesis through a novel NDY1/KDM2B-miR101-EZH2 pathway

P. Tsichlis, C. Polytarchou, S. Kampranis, 2011 .

A Novel Plant Glutathione S-Transferase/Peroxidase Suppresses Bax Lethality in Yeast*

M. Atallah, P. Tsichlis, G. Toby, 2000, The Journal of Biological Chemistry.

Distinct roles in NKT cell maturation and function for the different transcription factors in the classical NF‐κB pathway

S. Gerondakis, R. Grumont, P. Tsichlis, 2011, Immunology and cell biology.

Tpl2/Cot Signals Activate ERK, JNK, and NF-κB in a Cell-type and Stimulus-specific Manner*

Jeonghee Cho, M. Kelliher, A. Eliopoulos, 2005, Journal of Biological Chemistry.

c-Jun N-Terminal Kinases Mediate Reactivation of Akt and Cardiomyocyte Survival After Hypoxic Injury In Vitro and In Vivo

Yow-Ming C Wang, F. Salituro, P. Tsichlis, 2005, Circulation research.

AKT signaling in normal and malignant cells

J. Testa, P. Tsichlis, 2005, Oncogene.

The SH2-like Akt homology (AH) domain of c-akt is present in multiple copies in the genome of vertebrate and invertebrate eucaryotes. Cloning and characterization of the Drosophila melanogaster c-akt homolog Dakt1.

T. Franke, P. Tsichlis, K. Tartof, 1994, Oncogene.

Prospective Evaluation of Effect of Metformin on Activation of AMP-activated Protein Kinase (AMPK) and Disease Control in a Sub-group Analysis of Patients with GI Malignancies

M. Saif, P. Tsichlis, R. Martell, 2020, Journal of cellular signaling.

Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus

P. Tsichlis, E. Tili, S. Malstrom, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Genetic Dissection of the Cellular Pathways and Signaling Mechanisms in Modeled Tumor Necrosis Factor–induced Crohn's-like Inflammatory Bowel Disease

G. Kollias, R. Flavell, M. Gaestel, 2002, The Journal of experimental medicine.

The Gfi-1 protooncoprotein represses Bax expression and inhibits T-cell death.

C. Gilks, P. Tsichlis, H. Grimes, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Hyperlipidemia‐induced metabolic changes in regulatory T cells result in altered function

J. Bagley, P. Hinds, P. Tsichlis, 2021, European journal of immunology.

Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process

A. Tzatsos, P. Tsichlis, S. E. Bear, 2008, Proceedings of the National Academy of Sciences.

Constitutively Active Phosphatidylinositol 3-Kinase and AKT Are Sufficient to Stimulate the Epithelial Na+/H+ Exchanger 3*

M. Cavet, P. Tsichlis, M. Donowitz, 2001, The Journal of Biological Chemistry.

Tpl2 kinase regulates FcγR signaling and immune thrombocytopenia in mice

P. Tsichlis, M. Hatziapostolou, D. Boumpas, 2013, Journal of leukocyte biology.

A common region for proviral DNA integration in MoMuLV-induced rat thymic lymphomas

P. Tsichlis, Li-Fu Hu, P. Strauss, 1983, Nature.

Rearrangement of c‐myc, pim‐1 and Mlvi‐1 and trisomy of chromosome 15 in MCF‐ and moloney‐MuLV‐induced murine T‐cell leukemias

G. Klein, P. Tsichlis, J. Sumegi, 1986, International journal of cancer.

Sequences in the gag-pol-5'env region of avian leukosis viruses confer the ability to induce osteopetrosis.

J. Coffin, P. Tsichlis, H. Robinson, 1985, Virology.

Molecular cloning of avian myelocytomatosis virus (MC29) transforming sequences.

J. Lautenberger, R. Schulz, P. Tsichlis, 1981, Proceedings of the National Academy of Sciences of the United States of America.

TNF‐α signal transduction in rat neonatal cardiac myocytes: definition of pathways generating from the TNF‐α receptor

C. Croce, M. Latronico, G. Condorelli, 2002 .

Replacement of interleukin-2 (IL-2)-generated mitogenic signals by a mink cell focus-forming (MCF) or xenotropic virus-induced IL-9-dependent autocrine loop: implications for MCF virus-induced leukemogenesis

P. Tsichlis, S. E. Bear, M. Flubacher, 1994, Journal of virology.

The activated Mlvi-4 locus in Moloney murine leukemia virus-induced rat T-cell lymphomas encodes an env/Mlvi-4 fusion protein

P. Tsichlis, C. Patriotis, 1994, Journal of virology.

Activation of the prolactin receptor gene by promoter insertion in a Moloney murine leukemia virus-induced rat thymoma

N. Copeland, D. Gilbert, N. Jenkins, 1992, Journal of virology.

Expression of leukemogenic recombinant viruses associated with a recessive gene in HRS/J mice

R. Schwartz, J. Coffin, P. Tsichlis, 1980, The Journal of experimental medicine.

Chromosomal localization of a gene, GF1, encoding a novel zinc finger protein reveals a new syntenic region between man and rodents.

C. Gilks, N. Copeland, D. Gilbert, 1995, Cytogenetics and cell genetics.

Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells

P. Tsichlis, C. Tsatsanis, A. Margioris, 2008, Proceedings of the National Academy of Sciences.

Akt1, EMSY, BRCA2 and type I IFN signaling: A novel arm of the IFN response

P. Tsichlis, Scott A. Ezell, 2012, Transcription.

Unequal Contribution of Akt Isoforms in the Double-Negative to Double-Positive Thymocyte Transition1

T. Ludwig, P. Tsichlis, D. Wiest, 2007, The Journal of Immunology.

AKT inhibition in the central nervous system induces signaling defects resulting in psychiatric symptomatology

R. Armen, A. Tsimberidou, P. Tsichlis, 2022, Cell & bioscience.

Commitment Expression , and T Cell Lineage α Receptor Leads to Defects in T Cell Activation , IL-7 Growth Factor Independence-1 B Expression

T. Hoang, A. Singer, P. Tsichlis, 2003 .

Toll-Like Receptor 2-Dependent Extracellular Signal-Regulated Kinase Signaling in Mycobacterium tuberculosis-Infected Macrophages Drives Anti-Inflammatory Responses and Inhibits Th1 Polarization of Responding T Cells

P. Tsichlis, C. Harding, W. Boom, 2015, Infection and Immunity.

Phospho-IWS1-dependent U2AF2 splicing is cell-cycle-regulated, promotes proliferation and predicts poor prognosis of EGFR- mutant lung adenocarcinoma

A. Hatzigeorgiou, D. Carbone, V. Coppola, 2020, bioRxiv.

Subgroup-E avian-leukosis-virus-associated disease in chickens.

J. Coffin, P. Tsichlis, D. DeSimone, 1980, Cold Spring Harbor symposia on quantitative biology.

Ablation of Tumor Progression Locus 2 Promotes a Type 2 Th Cell Response in Ovalbumin-Immunized Mice

J. O’Shea, W. Watford, A. Eliopoulos, 2009, The Journal of Immunology.

Ovalbumin-Immunized Mice Promotes a Type 2 Th Cell Response in Ablation of Tumor Progression Locus 2

J. O’Shea, W. Watford, A. Eliopoulos, 2009 .

Adhesion, and Survival R-Ras-Mediated Cellular Transformation, Differential Roles of Akt, Rac, and Ral in

P. Tsichlis, A. Kimmelman, M. Osada, 2014 .

Ovalbumin-Immunized Mice a Type 2 Th Cell Response in Ablation of Tumor Progression Locus 2 Promotes

J. O’Shea, W. Watford, A. Eliopoulos, 2011 .

The transforming sequences of avian myelocytomatosis virus (MC29).

J. Lautenberger, R. Schulz, P. Tsichlis, 1981, Journal of supramolecular structure and cellular biochemistry.

Sequence comparison in the crossover region of an oncogenic avian retrovirus recombinant and its nononcogenic parent: genetic regions that control growth rate and oncogenic potential

L. Donehower, G. Hager, S. Astrin, 1982, Molecular and cellular biology.

Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation.

P. Tsichlis, C. Patriotis, A. Makris, 1993, Proceedings of the National Academy of Sciences of the United States of America.

The NF‐κB1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties

A. Strasser, G. Belz, Meredith O'Keeffe, 2012, The EMBO journal.

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

Andrius Kazlauskas, David R Kaplan, D. Morrison, 1995, Cell.

Akt isoforms in the immune system

P. Tsichlis, M. Guerau-de-Arellano, Z. Piedra-Quintero, 2022, Frontiers in Immunology.

Proline hydroxylation linked to Akt activation

P. Tsichlis, M. Voulgarelis, 2016, Science.

Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40

C. Dumitru, A. Eliopoulos, P. Tsichlis, 2003, The EMBO journal.

Effects of provirus integration in the Tpl-1/Ets-1 locus in Moloney murine leukemia virus-induced rat T-cell lymphomas: levels of expression, polyadenylation, transcriptional initiation, and differential splicing of the Ets-1 mRNA

N. Copeland, N. Jenkins, P. Lazo, 1994, Journal of virology.

The rat leukocyte antigen MRC OX-44 is a member of a new family of cell surface proteins which appear to be involved in growth regulation

P. Lazo, P. Tsichlis, A. Bellacosa, 1991, Molecular and cellular biology.

H-2-Mediated resistance to an ecotropic type C retrovirus: Localization of controlling genes and ontogenic studies of resistance

P. Tsichlis, S. E. Bear, Robert S. Schwanz, 2005, Immunogenetics.

Thymocyte Transition Double-Negative to Double-Positive Unequal Contribution of Akt Isoforms in the

T. Ludwig, P. Tsichlis, D. Wiest, 2007 .

Mutant and recombinant avian retroviruses with extended host range.

J. Coffin, P. Tsichlis, K. Conklin, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Cellular DNA region involved in induction of thymic lymphomas (Mlvi-2) maps to mouse chromosome 15

C. Kozak, P. Tsichlis, P. Strauss, 1984, Molecular and cellular biology.

Tcl1 enhances Akt kinase activity and mediates its nuclear translocation.

Y. Pekarsky, C. Hallas, G. Russo, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Activation of the Mlvi-1 / misl / pvt-1 locus in Moloney murine leukemia virus-induced T-cell lymphomas ( thymic lymphoma / common region of provirus integration / chromosomal translocation / ampliflcation / oncogenesis )

P. Tsichlis, S. E. Bear, B. Shepherd, 2022 .

Activation of multiple genes by provirus integration in the Mlvi-4 locus in T-cell lymphomas induced by Moloney murine leukemia virus

J. S. Lee, K. Huebner, N. Copeland, 1990, Journal of virology.

Overexpression of the SETD2 WW domain inhibits the phosphor-IWS1/SETD2 interaction and the oncogenic AKT/IWS1 RNA splicing program

P. Tsichlis, S. Acharya, G. Laliotis, 2021, bioRxiv.

The Tpl-2 protooncoprotein activates the nuclear factor of activated T cells and induces interleukin 2 expression in T cell lines.

P. Tsichlis, C. Patriotis, S. E. Bear, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Activation of the Mlvi-1/mis1/pvt-1 locus in Moloney murine leukemia virus-induced T-cell lymphomas.

P. Tsichlis, S. E. Bear, B. Shepherd, 1989, Proceedings of the National Academy of Sciences of the United States of America.

TPL2 Kinase Is a Crucial Signaling Factor and Mediator of NKT Effector Cytokine Expression in Immune-Mediated Liver Injury

A. Eliopoulos, P. Tsichlis, G. Nikolaidis, 2016, The Journal of Immunology.

Insertion of an Alu SINE in the human homologue of the Mlvi-2 locus.

P. Tsichlis, A. Economou-Pachnis, 1985, Nucleic Acids Research.

IWS1 phosphorylation by AKT3 controls nuclear export of type I IFN mRNAs and sensitivity to oncolytic viral infection, by regulating the alternative RNA splicing of U2AF2

V. Coppola, P. Tsichlis, C. Tsatsanis, 2020, bioRxiv.

MicroRNAs Differentially Regulated by Akt Isoforms Control EMT and Stem Cell Renewal in Cancer Cells

Kevin Struhl, Philip N. Tsichlis, Dimitrios Iliopoulos, 2009, Science Signaling.

Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission.

Kevin Struhl, Dimitrios Iliopoulos, K. Struhl, 2009, Cancer research.

Tyrosine 1062 of RET-MEN2A mediates activation of Akt (protein kinase B) and mitogen-activated protein kinase pathways leading to PC12 cell survival.

G. D. Vita, M. Santoro, A. Fusco, 2000, Cancer research.

Human homologue of Moloney leukemia virus integration-4 locus (MLVI-4), located 20 kilobases 3' of the myc gene, is rearranged in multiple myelomas.

A. Palumbo, C. Croce, K. Huebner, 1990, Cancer research.

Transcriptome Analysis of Human Endogenous Retroviruses at Locus-Specific Resolution in Non-Small Cell Lung Cancer

C. Croce, G. Nigita, A. Pulvirenti, 2022, Cancers.

Severe fever with thrombocytopenia syndrome phlebovirus non-structural protein activates TPL2 signalling pathway for viral immunopathogenesis

P. Tsichlis, Jae U. Jung, Su-Jin Park, 2019, Nature Microbiology.

Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation.

Booki Min, W. Paul, Jinfang Zhu, 2002, Immunity.

Akt Forms an Intracellular Complex with Heat Shock Protein 90 (Hsp90) and Cdc37 and Is Destabilized by Inhibitors of Hsp90 Function*

N. Rosen, D. Solit, G. Chiosis, 2002, The Journal of Biological Chemistry.

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase.

L. Cantley, T. Roberts, D. Fruman, 1997, Science.

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

J. Cheng, A. Godwin, J. Testa, 1992, Proceedings of the National Academy of Sciences of the United States of America.

AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation.

P. Tsichlis, T. Chan, P N Tsichlis, 1999, Annual review of biochemistry.

Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway*

N. Rosen, P. Tsichlis, H. Grimes, 1998, The Journal of Biological Chemistry.

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region.

J. Testa, P. Tsichlis, A. Bellacosa, 1991, Science.

Differential Splicing Generates Tvl-1/RFXANK Isoforms with Different Functions*

P. Tsichlis, J. Papamatheakis, Santasabuj Das, 2002, The Journal of Biological Chemistry.

The Mlvi-1 locus involved in the induction of rat T-cell lymphomas and the pvt-1/Mis-1 locus are identical

P. Lazo, P. Tsichlis, J. Lee, 1989, Journal of virology.

At least two regions of the viral genome determine the oncogenic potential of avian leukosis viruses.

J. Coffin, P. Tsichlis, H. Robinson, 1982, Proceedings of the National Academy of Sciences of the United States of America.

Role of the C region in relative growth rates of endogenous and exogenous avian oncoviruses.

J. Coffin, P. Tsichlis, 1980, Cold Spring Harbor Symposia on Quantitative Biology.

Activation oftheProlactin Receptor GenebyPromoter Insertion inaMoloneyMurineLeukemia Virus-Induced RatThymoma

N. Copeland, D. Gilbert, N. Jenkins, 1992 .

Cellular DNA regions involved in the induction of rat thymic lymphomas (Mlvi-1, Mlvi-2, Mlvi-3, and c-myc) represent independent loci as determined by their chromosomal map location in the rat

P. Tsichlis, G. Levan, C. Szpirer, 1985, Journal of virology.

Phosphorylation of TPL-2 on Serine 400 Is Essential for Lipopolysaccharide Activation of Extracellular Signal-Regulated Kinase in Macrophages

P. Tsichlis, M. Robinson, S. Ley, 2007, Molecular and Cellular Biology.

Faculty of 1000 evaluation for Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.

D. Wotton, P. Tsichlis, 2006 .

Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation

J. Brugge, P. Tsichlis, T. Chan, 1997, Molecular and cellular biology.

The human homolog of the Moloney leukemia virus integration 2 locus (MLV12) maps to band p14 of chromosome 5.

S. O’Brien, A. Nienhuis, W. Modi, 1989, Genomics.

Recombination between two integrated proviruses, one of which was inserted near c-myc in a retrovirus-induced rat thymoma: implications for tumor progression

P. Lazo, P. Tsichlis, 1988, Journal of virology.

IWS1 phosphorylation by AKT kinase controls the nucleocytoplasmic export of type I IFNs and the sensitivity of lung adenocarcinoma cells to oncolytic viral infection, through U2AF2 RNA splicing

V. Coppola, P. Tsichlis, C. Tsatsanis, 2020 .

Multiple enhancer domains in the 3' terminus of the Prague strain of Rous sarcoma virus.

G. Khoury, P. Tsichlis, L. Laimins, 1984, Nucleic acids research.

Viral sequences determining the oncogenicity of avian leukosis viruses.

B. Cullen, A. Skalka, P. Tsichlis, 1983, Progress in clinical and biological research.

Recombinants between endogenous and exogenous avian tumor viruses: role of the C region and other portions of the genome in the control of replication and transformation

J. Coffin, P. Tsichlis, 1980, Journal of virology.

Genomes of endogenous and exogenous avian retroviruses.

J. Coffin, P. Tsichlis, H. Robinson, 1983, Virology.

VARIATION IN AVIAN RETROVIRUS GENOMES *

J. Coffin, P. Tsichlis, C. Barker, 1980, Annals of the New York Academy of Sciences.

VIRAL ENVELOPE GENES AND c REGIONS IN NON-ACUTE AVIAN LEUKOSIS VIRUS ASSOCIATED DISEASE

J. Coffin, P. Tsichlis, H. Robinson, 1980 .

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

Philip N. Tsichlis, Alicia Arranz, Katerina Vaporidi, 2012, Proceedings of the National Academy of Sciences.

Virus-host interactions and the pathogenesis of murine and human oncogenic retroviruses.

P. Lazo, P. Tsichlis, 1991, Current topics in microbiology and immunology.

Genetics of Leukemogenesis by A vian Leukosis Viruses

Robinson, J. Coffin, P. Tsichlis, 2005 .

Genetics of leukemogenesis by avian leukosis viruses.

J. Coffin, P. Tsichlis, H. Robinson, 1981, Haematology and blood transfusion.

Recombination between the defective component of an acute leukemia virus and Rous associated virus O, an endogenous virus of chickens.

J. Coffin, P. Tsichlis, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Cancer induction by insertional mutagenesis: the role of viral genes in avian leukosis virus induced cancers.

J. Coffin, P. Tsichlis, H. Robinson, 1983, Progress in clinical and biological research.

Induction of COX‐2 by LPS in macrophages is regulated by Tpl2‐dependent CREB activation signals

Jeonghee Cho, C. Dumitru, A. Eliopoulos, 2002, The EMBO journal.

Energy Depletion Inhibits Phosphatidylinositol 3-Kinase/Akt Signaling and Induces Apoptosis via AMP-activated Protein Kinase-dependent Phosphorylation of IRS-1 at Ser-794*

A. Tzatsos, P. Tsichlis, 2007, Journal of Biological Chemistry.

Influence of H-2 complex on susceptibility to infection by murine leukemia virus.

R. Schwartz, P. Tsichlis, J. Donnelly, 1977, Journal of immunology.

Genetic differences unrelated toH-2 inH-2 congenic mice

R. Schwartz, P. Tsichlis, S. Datta, 1978, Immunogenetics.

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI‐3k/Akt‐dependent pathway

B. Calabretta, P. Włodarski, M. Wasik, 1997, The EMBO journal.

p50cdc37 Acting in Concert with Hsp90 Is Required for Raf-1 Function

B. Cochran, P. Tsichlis, N. Grammatikakis, 1999, Molecular and Cellular Biology.

Histone demethylases and cancer.

P. Tsichlis, S. Kampranis, 2009, Advances in cancer research.

Akt activation by growth factors is a multiple-step process: the role of the PH domain

Frank McCormick, Alfonso Bellacosa, David Stokoe, 1998, Oncogene.

RETRACTED ARTICLE: AKT3-mediated IWS1 phosphorylation promotes the proliferation of EGFR-mutant lung adenocarcinomas through cell cycle-regulated U2AF2 RNA splicing

A. Hatzigeorgiou, D. Carbone, V. Coppola, 2021, Nature Communications.

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase.

P. Tsichlis, H. Grimes, T. Chan, 1997, Proceedings of the National Academy of Sciences of the United States of America.

A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis.

G. Hu, P. Hinds, P. Tsichlis, 2009, Cancer research.

The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.

Alfonso Bellacosa, Lionel Larue, F. van Roy, 2003, Cancer research.

Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice.

S. Naber, P. Tsichlis, I. Maroulakou, 2007, Cancer research.

IWS1 phosphorylation promotes cell proliferation and predicts poor prognosis in EGFR mutant lung adenocarcinoma patients, through the cell cycle-regulated U2AF2 RNA splicing_images_depository

A. Hatzigeorgiou, D. Carbone, V. Coppola, 2020 .

New markers, D16FC1 and Tp12, differentiate between rat chromosomes 16 and 17.

A. Knudson, J. Testa, P. Tsichlis, 1993, Cytogenetics and cell genetics.

Regulation of Experimental Autoimmune Encephalomyelitis by TPL-2 Kinase

G. Kollias, M. Veldhoen, B. Stockinger, 2014, The Journal of Immunology.

TNF-α Induction by LPS Is Regulated Posttranscriptionally via a Tpl2/ERK-Dependent Pathway

G. Kollias, K. Stamatakis, N. Copeland, 2000, Cell.

Liver fatty acid binding protein is the mitosis-associated polypeptide target of a carcinogen in rat hepatocytes.

P. Tsichlis, J. Bassuk, S. Sorof, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.

D. Iliopoulos, A. Guo, P. Tsichlis, 2014, Molecular cell.

CLAP, a Novel Caspase Recruitment Domain-containing Protein in the Tumor Necrosis Factor Receptor Pathway, Regulates NF-κB Activation and Apoptosis*

S. Srinivasula, E. Alnemri, T. Fernandes-Alnemri, 1999, The Journal of Biological Chemistry.

Small Cell Lung Cancer: Subtypes and Therapeutic Implications.

D. Carbone, P. Tsichlis, J. Amann, 2022, Seminars in cancer biology.

The epigenetic factor KDM2B regulates cell adhesion, small rho GTPases, actin cytoskeleton and migration in prostate cancer cells.

G. Kallergi, C. Stournaras, P. Tsichlis, 2018, Biochimica et biophysica acta. Molecular cell research.

PRMT5 Promotes Symmetric Dimethylation of RNA Processing Proteins and Modulates Activated T Cell Alternative Splicing and Ca2+/NFAT Signaling

K. Patrick, K. Lynch, P. Tsichlis, 2021, ImmunoHorizons.

/NFAT Signaling 2+ Alternative Splicing and Ca Processing Proteins and Modulates Activated T Cell PRMT5 Promotes Symmetric Dimethylation of RNA

K. Patrick, K. Lynch, P. Tsichlis, 2021 .

Insertion of long interspersed repeated elements at the Igh (immunoglobulin heavy chain) and Mlvi-2 (Moloney leukemia virus integration 2) loci of rats.

A. Furano, P. Tsichlis, A. Economou-Pachnis, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Chromosomal localization of the Ox-44 (CD53) leukocyte antigen gene in man and rodents.

N. Copeland, D. Gilbert, N. Jenkins, 1993, Cytogenetics and cell genetics.

Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit.

G. Panayotou, U. Rodeck, P. Tsichlis, 2002, Cancer Cell.

Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer.

Peter J. Belmont, Erin M. Coffee, M. Sinnamon, 2014, Cancer letters.

The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal

P. Tsichlis, H. Grimes, T. Chan, 1996, Molecular and cellular biology.

Akt3 induces oxidative stress and DNA damage by activating the NADPH oxidase via phosphorylation of p47phox

T. Yau, P. Hinds, P. Tsichlis, 2020, Proceedings of the National Academy of Sciences.

RNAdetector: a free user-friendly stand-alone and cloud-based system for RNA-Seq data analysis

Francesco Bertoni, Salvatore Alaimo, Alessandro La Ferlita, 2021, BMC Bioinformatics.

The JmjC Domain Histone Demethylase Ndy1 Regulates Redox Homeostasis and Protects Cells from Oxidative Stress

P. Tsichlis, C. Polytarchou, M. Hatziapostolou, 2008, Molecular and Cellular Biology.

A phase I delayed-start, randomized and pharmacodynamic study of metformin and chemotherapy in patients with solid tumors

P. Tsichlis, R. Martell, E. Grimm, 2019, Cancer Chemotherapy and Pharmacology.

Regulation of the Akt kinase by interacting proteins

P. Tsichlis, Philip N Tsichlis, Keyong Du, 2005, Oncogene.

Analyses of publicly available genomics resources define FGF-2-expressing bladder carcinomas as EMT-prone, proliferative tumors with low mutation rates and high expression of CTLA-4, PD-1 and PD-L1

P. Tsichlis, E. McNiel, 2017, Signal Transduction and Targeted Therapy.

Pathogenicity of retroviruses containing either the normal human c-Ha-ras1 gene or its mutated form derived from the bladder carcinoma EJ/T24 cell line.

E. Chang, K. Pirollo, P. Tsichlis, 1985, Journal of experimental pathology.

Splice acceptor site for the env message of Moloney murine leukemia virus

P. Lazo, P. Tsichlis, V. Prasad, 1987, Journal of virology.

Activation of the c-fos serum response element by phosphatidyl inositol 3-kinase and rho pathways in HeLa cells.

B. Lim, J. Settleman, J. Schlessinger, 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells.

S. Naber, P. Hinds, C. Kuperwasser, 2014, Cancer research.

FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway.

P. Tsichlis, C. Polytarchou, Ioannis Sanidas, 2011, Molecular cell.

Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells.

K. Struhl, H. Hirsch, D. Iliopoulos, 2010, Molecular cell.

Long-distance activation of the Myc protooncogene by provirus insertion in Mlvi-1 or Mlvi-4 in rat T-cell lymphomas.

J. S. Lee, P. Lazo, P. Tsichlis, 1990, Proceedings of the National Academy of Sciences of the United States of America.

AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells.

J E Paciga, S. Nicosia, J. Cheng, 2001, The American journal of pathology.

Akt, a Target of Phosphatidylinositol 3-Kinase, Inhibits Apoptosis in a Differentiating Neuronal Cell Line

N. Hay, P. Tsichlis, A. Bellacosa, 1998, Molecular and Cellular Biology.

The Oncogenic Protein Kinase Tpl-2/Cot Contributes to Epstein-Barr Virus-Encoded Latent Infection Membrane Protein 1-Induced NF-κB Signaling Downstream of TRAF2

L. Young, A. Eliopoulos, P. Murray, 2002, Journal of Virology.

In vivo genome editing and organoid transplantation models of colorectal cancer

Francisco J. Sánchez-Rivera, T. Jacks, A. Bass, 2017, Nature Biotechnology.

Akt isoform-specific effects on thyroid cancer development and progression in a murine thyroid cancer model

K. Coombes, K. L. La Perle, P. Tsichlis, 2020, Scientific Reports.

The First Study Evaluating the Safety of Pre-Surgery Administration of Metformin in Patients with Colorectal and other Gastrointestinal Cancers and Effect on Cancer Stem Cells.

M. Saif, P. Tsichlis, R. Martell, 2021, Cancer medicine journal.

Diagnostic planning using computer assisted decision‐making for patients with Hodgkin's disease

C Safran, C. Safran, A. Bluming, 1977, Cancer.

Decision analysis to evaluate lymphangiography in the management of patients with Hodgkin's disease.

C Safran, C. Safran, A. Bluming, 1977, The New England journal of medicine.

Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation.

Kevin Struhl, Dimitrios Iliopoulos, K. Struhl, 2011, Cancer research.

Tumor and Stem Cell Biology Akt 2 Regulates All Akt Isoforms and Promotes Resistance to Hypoxia through Induction of miR-21 upon Oxygen Deprivation

K. Struhl, D. Iliopoulos, P. Tsichlis, 2011 .

MicroRNA214 Is Associated With Progression of Ulcerative Colitis, and Inhibition Reduces Development of Colitis and Colitis-Associated Cancer in Mice.

D. Iliopoulos, T. Palumbo, D. Hommes, 2015, Gastroenterology.

T-cell lymphoma lines derived from rat thymomas induced by Moloney murine leukemia virus: phenotypic diversity and its implications

P. Lazo, P. Tsichlis, Andres J Klein-Szanto, 1990, Journal of virology.

Target sites for the transposition of rat long interspersed repeated DNA elements (LINEs) are not random.

A. Furano, P. Tsichlis, C. Somerville, 1986, Nucleic acids research.

AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation

D. Morrison, E. Golemis, D. Kaplan, 1995, Molecular and cellular biology.

TPL-2 negatively regulates interferon-β production in macrophages and myeloid dendritic cells

Frank Kaiser, Philip N. Tsichlis, P. Ricciardi-Castagnoli, 2009, The Journal of experimental medicine.

Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor

P. Tsichlis, H. Grimes, P. Zweidler-McKay, 1996, Molecular and cellular biology.

Akt Is a Direct Target of the Phosphatidylinositol 3-Kinase

P. Tsichlis, T. Chan, A. Bellacosa, 1996, The Journal of Biological Chemistry.

TPL-2–ERK1/2 Signaling Promotes Host Resistance against Intracellular Bacterial Infection by Negative Regulation of Type I IFN Production

D. Chaussabel, Anna R Martirosyan, P. Tsichlis, 2013, The Journal of Immunology.

TPL2 kinase is a suppressor of lung carcinogenesis

Urszula Oleksiewicz, John K Field, Georgios Nikolaidis, 2013, Proceedings of the National Academy of Sciences.

Tumor Progression Locus-2 Is a Critical Regulator of Pancreatic and Lung Inflammation during Acute Pancreatitis*

P. Tsichlis, Santasabuj Das, M. Steer, 2007, Journal of Biological Chemistry.

Tpl2 (Tumor Progression Locus 2) Phosphorylation at Thr290 Is Induced by Lipopolysaccharide via an Iκ-B Kinase-β-dependent Pathway and Is Required for Tpl2 Activation by External Signals*

Jeonghee Cho, P. Tsichlis, M. Melnick, 2005, Journal of Biological Chemistry.

Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide.

Jeonghee Cho, P. Tsichlis, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Tpl‐2 induces apoptosis by promoting the assembly of protein complexes that contain caspase‐9, the adapter protein Tvl‐1, and procaspase‐3

S. Srinivasula, E. Alnemri, P. Tsichlis, 2001, Journal of cellular physiology.

Integration of Metabolomics and Gene Expression Profiling Elucidates IL4I1 as Modulator of Ibrutinib Resistance in ABC-Diffuse Large B Cell Lymphoma

P. Tsichlis, R. Baiocchi, L. Alinari, 2021, Cancers.

Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus

A. Tzatsos, P. Tsichlis, S. Kampranis, 2009, Proceedings of the National Academy of Sciences.

Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-κB

P. Tsichlis, C. Patriotis, C. Tsatsanis, 1998, Oncogene.

Old Yellow Enzymes, Highly Homologous FMN Oxidoreductases with Modulating Roles in Oxidative Stress and Programmed Cell Death in Yeast*

P. Tsichlis, A. Makris, H. Khalil, 2007, Journal of Biological Chemistry.

Provirus insertion in Tpl-1, an Ets-1-related oncogene, is associated with tumor progression in Moloney murine leukemia virus-induced rat thymic lymphomas.

N. Copeland, N. Jenkins, P. Lazo, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Timing is everything: regulation of Cdk1 and aneuploidy.

P. Hinds, P. Tsichlis, M. Hatziapostolou, 2007, Developmental cell.

Prolactin (PRL)-dependent expression of a zinc finger protein-encoding gene, Gfi-1, in Nb2 lymphoma cells: constitutive expression in autonomous sublines.

C. Gilks, P. Tsichlis, C. Barker, 1995, Endocrinology.

Replication of JC Virus DNA in the G144 Oligodendrocyte Cell Line Is Dependent Upon Akt

P. Phelan, P. Tsichlis, B. Lin, 2017, Journal of Virology.

Tumor Progression Locus 2 Mediates Signal-Induced Increases in Cytoplasmic Calcium and Cell Migration

P. Tsichlis, C. Polytarchou, M. Hatziapostolou, 2011, Science Signaling.

TNF-alpha signal transduction in rat neonatal cardiac myocytes: definition of pathways generating from the TNF-alpha receptor.

C. Croce, M. Latronico, G. Condorelli, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Identification of Structural Elements of the Lysine Specific Demethylase 2B CxxC Domain Associated with Replicative Senescence Bypass in Primary Mouse Cells

C. Stournaras, P. Tsichlis, C. Tsatsanis, 2020, The Protein Journal.

Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity.

P. Tsichlis, G. Laliotis, Shouvonik Sengupta, 2020, The Journal of clinical investigation.

The Epigenetic Factor KDM2B Regulates EMT and Small GTPases in Colon Tumor Cells

G. Kallergi, C. Stournaras, P. Tsichlis, 2018, Cellular Physiology and Biochemistry.

Cell-mediated immunity in systemic lupus erythematosus.

J. Sharp, P. Tsichlis, S. Marketos, 1977, Clinical and experimental immunology.

T-Cell LymphomaLinesDerived fromRatThymomasInduced by MoloneyMurineLeukemia Virus: Phenotypic Diversity andItsImplications

P. Lazo, P. Tsichlis, P. Klein-Szanto, 1990 .

PHENSIM: Phenotype Simulator

Salvatore Alaimo, Alessandro La Ferlita, Alfredo Pulvirenti, 2020, bioRxiv.

Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation

A. Eliopoulos, P. Tsichlis, C. Tsatsanis, 2012, Proceedings of the National Academy of Sciences.

The Ankyrin Repeat-containing Adaptor Protein Tvl-1 Is a Novel Substrate and Regulator of Raf-1*

R. Brent, E. Golemis, P. Tsichlis, 1999, The Journal of Biological Chemistry.

Characterization of phosphorylation sites on Tpl2 using IMAC enrichment and a linear ion trap mass spectrometer.

M. Ivan, P. Tsichlis, P. Vouros, 2007, Journal of proteome research.

PDK2: A Complex Tail in One Akt

P. Tsichlis, T. Chan, P N Tsichlis, 2001, Science's STKE.

Cdc123 and Checkpoint Forkhead Associated with RING Proteins Control the Cell Cycle by Controlling eIF2γ Abundance*

C. Brenner, P. Tsichlis, P. Bieganowski, 2004, Journal of Biological Chemistry.

AKT Isoforms in Macrophage Activation, Polarization, and Survival.

P. Tsichlis, C. Tsatsanis, Eleni Vergadi, 2022, Current topics in microbiology and immunology.

Infection by mink cell focus-forming viruses confers interleukin 2 (IL-2) independence to an IL-2-dependent rat T-cell lymphoma line.

P. Tsichlis, S. E. Bear, 1991, Proceedings of the National Academy of Sciences of the United States of America.

The combination of TPL2 knockdown and TNFα causes synthetic lethality via caspase-8 activation in human carcinoma cell lines

C. Croce, P. Tsichlis, M. Paraskevopoulou, 2019, Proceedings of the National Academy of Sciences.

A phase I study of metformin and chemotherapy in solid tumors.

P. Tsichlis, R. Martell, E. Grimm, 2014 .

Biology and pathogenesis of retroviruses.

P. Lazo, P. Tsichlis, 1990, Seminars in oncology.

Induction of multiple independent T-cell lymphomas in rats inoculated with MOloney murine leukemia virus.

S. Shinton, P. Lazo, P. Tsichlis, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Oncogenesis by Moloney murine leukemia virus.

P. Tsichlis, 1987, Anticancer research.

VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase

V. Sridharan, P. Tsichlis, J. Eldridge, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Severe fever with thrombocytopenia syndrome phlebovirus non-structural protein activates TPL2 signalling pathway for viral immunopathogenesis

P. Tsichlis, Jae U. Jung, Su-Jin Park, 2019, Nature Microbiology.

Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4

G. Nigita, P. Tsichlis, A. Ferlita, 2023, bioRxiv.

Exploiting the fibroblast growth factor receptor-1 vulnerability to therapeutically restrict the MYC-EZH2-CDKN1C axis-driven proliferation in Mantle cell lymphoma

Ryan D. Morin, R. Morin, K. Young, 2023, Leukemia.

Corrigendum: In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis

Francisco J. Sánchez-Rivera, T. Jacks, A. Bass, 2017, Nature Biotechnology.

NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells.

S. Naber, P. Hinds, C. Kuperwasser, 2014, Cancer research.

Replication of JC Virus DNA in the G144 Oligodendrocyte Cell Line Is Dependent Upon Akt

P. Phelan, P. Tsichlis, B. Lin, 2017, Journal of Virology.

A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis.

G. Hu, P. Hinds, P. Tsichlis, 2009, Cancer research.

Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission.

K. Struhl, H. Hirsch, D. Iliopoulos, 2009, Cancer research.

Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process

A. Tzatsos, P. Tsichlis, S. E. Bear, 2008, Proceedings of the National Academy of Sciences.

A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases.

K. Struhl, S. Jaeger, M. Bulyk, 2010, Cancer cell.

A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18.

V. Chapman, M. Justice, K. Kinzler, 1992, Genomics.