I. Winkler

发表

Cell Adhesion Molecules in Normal and Malignant Hematopoiesis: from Bench to Bedside

J. Lévesque, I. Winkler, 2016, Current Stem Cell Reports.

CD169+ macrophages mediate pathological formation of woven bone in skeletal lesions of prostate cancer

J. Lévesque, I. Winkler, M. Ling, 2016, The Journal of pathology.

A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity

H. Jinnah, J. Lévesque, I. Winkler, 2012, Gut.

B-lymphopoiesis is stopped by mobilizing doses of G-CSF and is rescued by overexpression of the anti-apoptotic protein Bcl2

Lisa M. Sedger, J. Lévesque, I. Winkler, 2013, Haematologica.

Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance

Michael R. Tallack, A. Perkins, J. Rasko, 2020, Nature Communications.

Acute Myeloid Leukemia Chemo-Resistance Is Mediated by E-selectin Receptor CD162 in Bone Marrow Niches

J. Lévesque, I. Winkler, Valérie Barbier, 2020, Frontiers in Cell and Developmental Biology.

The role of mesenchymal stem cells in hematopoiesis

J. Lévesque, I. Winkler, R. Jacobsen, 2017 .

Cellular players of hematopoietic stem cell mobilization in the bone marrow niche

J. Lévesque, I. Winkler, Joshua Tay, 2017, International Journal of Hematology.

HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1α

J. Lévesque, I. Winkler, Carl R Walkley, 2015, Leukemia.

Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML

A. Zannettino, R. D'Andrea, D. Pattabiraman, 2015, Leukemia.

Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment.

B. Williams, J. Lévesque, I. Winkler, 2002, Experimental hematology.

Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells.

J. Lévesque, I. Winkler, P. Simmons, 2003, Experimental hematology.

Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation

J. Lévesque, I. Winkler, N. Sims, 2012, Leukemia.

Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells independent of PSGL-1.

J. Lévesque, I. Winkler, P. Simmons, 2004, Blood.

It takes nerves to recover from chemotherapy

J. Lévesque, I. Winkler, 2013, Nature Medicine.

The endosteal ‘osteoblastic’ niche and its role in hematopoietic stem cell homing and mobilization

J. Lévesque, I. Winkler, Falak M. Helwani, 2010, Leukemia.

Mechanisms of hematopoietic stem cell mobilization: when innate immunity assails the cells that make blood and bone.

J. Lévesque, I. Winkler, 2006, Experimental hematology.

Engraftment Outcomes after HPC Co-Culture with Mesenchymal Stromal Cells and Osteoblasts

J. Lévesque, I. Winkler, M. Doran, 2013, Journal of clinical medicine.

Hierarchy of immature hematopoietic cells related to blood flow and niche

J. Lévesque, I. Winkler, 2011, Current opinion in hematology.

G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow.

D. Link, J. Lévesque, I. Winkler, 2005, Blood.

Hematopoietic Progenitor Cell Mobilization Results in Hypoxia with Increased Hypoxia‐Inducible Transcription Factor‐1α and Vascular Endothelial Growth Factor A in Bone Marrow

B. Williams, S. Nilsson, J. Lévesque, 2007, Stem cells.

Contrasting effects of P-selectin and E-selectin on the differentiation of murine hematopoietic progenitor cells.

J. Lévesque, I. Winkler, L. Purton, 2005, Experimental hematology.

Neurological heterotopic ossification following spinal cord injury is triggered by macrophage‐mediated inflammation in muscle

D. Hutmacher, M. Le Bousse-Kerdilès, J. Lévesque, 2015, The Journal of pathology.

Mobilisation strategies for normal and malignant cells

J. Rasko, S. Nilsson, I. Lewis, 2011, Pathology.

Tissue engineered humanized bone supports human hematopoiesis in vivo.

J. Clements, D. Hutmacher, B. Holzapfel, 2015, Biomaterials.

niches and their depletion mobilizes HSCs Bone marrow macrophages maintain hematopoietic stem cell (HSC)

J. Lévesque, I. Winkler, N. Rooijen, 2010 .

myeloid leukemia (AML) by human AML oncogenes Interaction of c-Myb with p300 is required for the induction of acute

A. Perkins, K. Shakhbazov, R. Pattabiraman, 2014 .

MYELOID NEOPLASIA Interaction of c-Myb with p 300 is required for the induction of acute myeloid leukemia ( AML ) by human AML oncogenes

A. Perkins, S. Grimmond, K. Shakhbazov, 2014 .

Self-repopulating recipient bone marrow resident macrophages promote long-term hematopoietic stem cell engraftment.

D. Hume, A. Perkins, J. Lévesque, 2018, Blood.

Mobilization of CD8+ Central Memory T-Cells with Enhanced Reconstitution Potential in Mice By a Combination of G-CSF and GMI-1271-Mediated E-Selectin Blockade

J. Lévesque, I. Winkler, Julie M. Davies, 2015 .

Adhesion to E‐selectin primes macrophages for activation through AKT and mTOR

J. Lévesque, I. Winkler, Julie M. Davies, 2021, Immunology and cell biology.

Bacterial Lipopolysaccharides Suppress Erythroblastic Islands and Erythropoiesis in the Bone Marrow in an Extrinsic and G- CSF-, IL-1-, and TNF-Independent Manner

J. Lévesque, I. Winkler, K. Bisht, 2020, Frontiers in Immunology.

Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation.

J. Lévesque, I. Winkler, G. Walkinshaw, 2013, Blood.

irradiation quiescence in vivo and accelerates blood recovery after severe increases hematopoietic stem cell α Pharmacologic stabilization of HIF-1

J. Lévesque, I. Winkler, G. Walkinshaw, 2013 .

A rapid streptavidin-capture ELISA specific for the detection of antibodies to feline foamy virus.

M. Löchelt, R. Flügel, I. Winkler, 1997, Journal of immunological methods.

Mobilization of hematopoietic stem cells by depleting bone marrow macrophages.

J. Lévesque, I. Winkler, Valérie Barbier, 2012, Methods in molecular biology.

Mobilization of hematopoietic stem cells: state of the art

J. Lévesque, I. Winkler, 2008, Current opinion in organ transplantation.

Mobilization with granulocyte colony-stimulating factor blocks medullar erythropoiesis by depleting F4/80(+)VCAM1(+)CD169(+)ER-HR3(+)Ly6G(+) erythroid island macrophages in the mouse.

J. Lévesque, I. Winkler, N. Van Rooijen, 2014, Experimental hematology.

Oncostatin M regulates hematopoietic stem cell (HSC) niches in the bone marrow to restrict HSC mobilization

G. Müller-Newen, J. Lévesque, I. Winkler, 2021, Leukemia.

Fms-like tyrosine kinase 3 (Flt3) ligand depletes erythroid island macrophages and blocks medullar erythropoiesis in the mouse.

J. Lévesque, I. Winkler, M. Brunck, 2016, Experimental hematology.

AML ) by human AML oncogenes Interaction of c-Myb with p 300 is required for the induction of acute

A. Perkins, S. Grimmond, K. Shakhbazov, 2014 .

Mobilization of hematopoietic stem cells with highest self-renewal by G-CSF precedes clonogenic cell mobilization peak.

J. Lévesque, I. Winkler, E. Wiercinska, 2016, Experimental hematology.

Imaging flow cytometry reveals that G-CSF treatment causes loss of erythroblastic islands in the mouse bone marrow.

J. Lévesque, I. Winkler, K. Bisht, 2020, Experimental hematology.

Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization

J. Lévesque, I. Winkler, P. Coughlin, 2005, The Journal of experimental medicine.

Epidemiology of Feline Foamy Virus and Feline Immunodeficiency Virus Infections in Domestic and Feral Cats: a Seroepidemiological Study

M. Löchelt, I. Winkler, R. Flower, 1999, Journal of Clinical Microbiology.

Macrophages form erythropoietic niches and regulate iron homeostasis to adapt erythropoiesis in response to infections and inflammation.

J. Lévesque, I. Winkler, K. Bisht, 2021, Experimental hematology.

Mobilization of bone marrow-derived progenitors.

J. Rasko, J. Lévesque, I. Winkler, 2007, Handbook of experimental pharmacology.

Characterization of the genome of feline foamy virus and its proteins shows distinct features different from those of primate spumaviruses

M. Löchelt, R. Flügel, I. Winkler, 1997, Journal of virology.

Role of macrophages and phagocytes in orchestrating normal and pathological haematopoietic niches.

J. Lévesque, I. Winkler, K. Bisht, 2021, Experimental hematology.

SUPPLEMENTARY INFORMATION for Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes

Diwakar, A. Perkins, S. Grimmond, 2014 .

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs.

J. Lévesque, I. Winkler, N. Van Rooijen, 2010, Blood.

Detection and molecular characterisation of feline foamy virus serotypes in naturally infected cats.

M. Löchelt, R. Flügel, I. Winkler, 1998, Virology.

Characterization of the spliced pol transcript of feline foamy virus: the splice acceptor site of the pol transcript is located in gag of foamy viruses

M. Löchelt, R. Flügel, I. Winkler, 1996, Journal of virology.

Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance

J. Lévesque, I. Winkler, J. Patton, 2012, Nature Medicine.

Construction of infectious feline foamy virus genomes: cat antisera do not cross-neutralize feline foamy virus chimera with serotype-specific Env sequences.

M. Löchelt, R. Flügel, I. Winkler, 2000, Virology.

Granulocyte Colony-Stimulating Factor and an RARα Specific Agonist, VTP195183, Synergize to Enhance the Mobilization of Hematopoietic Progenitor Cells

J. Lévesque, I. Winkler, R. Chandraratna, 2007, Transplantation.

Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance

Michael R. Tallack, A. Perkins, J. Rasko, 2020, Nature Communications.

Blocking Vascular Niche E-Selectin Dampens AML Stem Cell Regeneration/Survival Potential In Vivo By Inhibiting MAPK/ERK and PI3K/AKT Signalling Pathways

J. Lévesque, I. Winkler, J. Magnani, 2019, Blood.

Nichotherapy for stem cells: there goes the neighborhood.

J. Rasko, J. Lévesque, I. Winkler, 2013, BioEssays : news and reviews in molecular, cellular and developmental biology.

HIF prolyl hydroxylase inhibitor FG-4497 enhances mouse hematopoietic stem cell mobilization via VEGFR2/KDR.

A. Perkins, J. Lévesque, I. Winkler, 2019, Blood advances.

Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches.

A. Zannettino, J. Lévesque, I. Winkler, 2010, Blood.

Prostacyclin is an endosteal bone marrow niche component and its clinical analog iloprost protects hematopoietic stem cell potential during stress

J. Lévesque, I. Winkler, Falak M. Helwani, 2021, Stem cells.

Endosteal Niches and Lymphopoiesis Are Inhibited during G-CSFInduced Hematopoietic Stem Cell Mobilization

J. Lévesque, I. Winkler, N. Sims, 2008 .

HEMATOPOIESIS AND STEM CELLS Pharmacologic stabilization of HIF-1 (cid:1) increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation

J. Lévesque, I. Winkler, G. Walkinshaw, 2013 .

Tissue Inhibitor of Metalloproteinase-3 (TIMP-3) Regulates Hematopoiesis and Bone Formation In Vivo

J. Lévesque, I. Winkler, N. Sims, 2010, PloS one.

Single-Cell Transcriptional Profiling of Aortic Endothelium Identifies a Hierarchy from Endovascular Progenitors to Differentiated Cells.

S. Andersen, S. Lukowski, K. Khosrotehrani, 2019, Cell reports.

Flow cytometry measurement of bone marrow perfusion in the mouse and sorting of progenitors and stems cells according to position relative to blood flow in vivo.

J. Lévesque, I. Winkler, R. Wadley, 2012, Methods in molecular biology.

Flow cytometry analysis of cell cycling and proliferation in mouse hematopoietic stem and progenitor cells.

J. Lévesque, I. Winkler, B. Nowlan, 2012, Methods in molecular biology.

P072 A novel mouse model relates thiopurine hepatic sinusoidal obstructive syndrome to dose-exposure of 6-thioguanosine nucleotides

I. Winkler, M. McGuckin, T. Florin, 2012 .

Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches.

A. Zannettino, J. Lévesque, I. Winkler, 2010, Blood.

Nichotherapy for stem cells: there goes the neighborhood.

J. Rasko, J. Lévesque, I. Winkler, 2013, BioEssays : news and reviews in molecular, cellular and developmental biology.

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs.

J. Lévesque, I. Winkler, N. Van Rooijen, 2010, Blood.

Mobilisation strategies for normal and malignant cells

S. Nilsson, I. Lewis, J. Lévesque, 2011, Pathology.

SUPPLEMENTARY INFORMATION for Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes

Diwakar, A. Perkins, S. Grimmond, 2014 .

Antibody to Human Foamy Virus Not Detected in Individuals Treated with Blood Products or in Blood Donors

R. Flügel, I. Winkler, K. Asikainen, 2000, Vox Sanguinis.

CD169+ macrophages mediate pathological formation of woven bone in skeletal lesions of prostate cancer

J. Lévesque, I. Winkler, M. Ling, 2016, The Journal of pathology.

Bacterial Lipopolysaccharides Exacerbate Neurogenic Heterotopic Ossification Development

J. Lévesque, I. Winkler, K. Bisht, 2023, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.