R. McKenna

R. McKenna, K. Pepin, J. Domsic, 2008, Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.

Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II.

C. D. Boone, D. Silverman, R. McKenna, 2012, Protein engineering, design & selection : PEDS.

Carbonic anhydrase inhibitors: a review on the progress of patent literature (2011–2016)

R. McKenna, C. Lomelino, 2016, Expert opinion on therapeutic patents.

Comparative Analysis of Adeno-Associated Virus Capsid Stability and Dynamics

R. McKenna, B. Bothner, M. Agbandje-McKenna, 2013, Journal of Virology.

Recombinant plasmepsin 1 from the human malaria parasite plasmodium falciparum: enzymatic characterization, active site inhibitor design, and structural analysis.

J. Dame, D. Rodríguez, H. Gutiérrez‐de‐Terán, 2009, Biochemistry.

Active-site specificity of digestive aspartic peptidases from the four species of Plasmodium that infect humans using chromogenic combinatorial peptide libraries.

J. Dame, B. Dunn, R. McKenna, 2005, Biochemistry.

An intramolecular lock facilitates folding and stabilizes the tertiary structure of Streptococcus mutans adhesin P1

J. R. Long, R. McKenna, L. Brady, 2014, Proceedings of the National Academy of Sciences.

Intramolecular proton shuttle supports not only catalytic but also noncatalytic function of carbonic anhydrase II

R. McKenna, J. Deitmer, C. Schüler, 2011, Proceedings of the National Academy of Sciences.

Completion of the AAV Structural Atlas: Serotype Capsid Structures Reveals Clade-Specific Features

R. McKenna, M. Agbandje-McKenna, P. Chipman, 2021, Viruses.

Sequestration of carbon dioxide by the hydrophobic pocket of the carbonic anhydrases.

R. McKenna, J. Domsic, 2010, Biochimica et biophysica acta.

Characterization of the Serpentine Adeno-Associated Virus (SAAV) Capsid Structure: Receptor Interactions and Antigenicity

D. Sousa, R. McKenna, M. Agbandje-McKenna, 2022, Journal of virology.

T. Baker, G. Cardone, N. Muzyczka, 2016, Journal of Virology.

Human Bocavirus Capsid Structure: Insights into the Structural Repertoire of the Parvoviridae

Kristin N. Parent, K. Parent, T. Baker, 2010, Journal of Virology.

The structure of human parvovirus B19 at 8 A resolution.

M. Rossmann, S. Kajigaya, N. Young, 1994, Virology.

Chapter 16 – Engineered Mammalian Carbonic Anhydrases for CO2 Capture

C. D. Boone, R. McKenna, 2015 .

Carbonic Anhydrase: An Efficient Enzyme with Possible Global Implications

C. D. Boone, R. McKenna, Sonika Gill, 2013 .

Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates.

C. Supuran, D. Vullo, R. McKenna, 2015, Journal of medicinal chemistry.

Water networks in fast proton transfer during catalysis by human carbonic anhydrase II.

D. Silverman, R. McKenna, C. Tu, 2013, Biochemistry.

Structural and Kinetic Effects on Changes in the CO2 Binding Pocket of Human Carbonic Anhydrase II

Chae Un Kim, D. Silverman, S. Gruner, 2012 .

Neutron Structure of Human Carbonic Anhydrase II : Implications for Proton Transfer † S

D. Silverman, R. McKenna, M. Mustyakimov, 2009 .

Role of hydrophilic residues in proton transfer during catalysis by human carbonic anhydrase II.

D. Silverman, R. McKenna, C. Tu, 2008, Biochemistry.

Role of a glutamate bridge spanning the dimeric interface of human manganese superoxide dismutase.

D. Silverman, R. McKenna, J. Domsic, 2008, Biochemistry.

Structural and kinetic study of differences between human and Escherichia coli manganese superoxide dismutases.

D. Silverman, R. McKenna, J. Domsic, 2007, Biochemistry.

Preliminary X-ray crystallographic analysis of α-carbonic anhydrase from Thiomicrospira crunogena XCL-2.

R. McKenna, K. Scott, S. Biswas, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

Role of zinc in catalytic activity of carbonic anhydrase IX.

D. Silverman, R. McKenna, C. Tu, 2012, Archives of biochemistry and biophysics.

Structural annotation of human carbonic anhydrases

C. D. Boone, R. McKenna, M. Aggarwal, 2013, Journal of enzyme inhibition and medicinal chemistry.

Catalytic mechanism of α-class carbonic anhydrases: CO2 hydration and proton transfer.

C. D. Boone, D. Silverman, R. McKenna, 2014, Sub-cellular biochemistry.

Preliminary X-ray crystallographic analysis of β-carbonic anhydrase psCA3 from Pseudomonas aeruginosa.

R. McKenna, S. Lotlikar, M. Patrauchan, 2013, Acta crystallographica. Section F, Structural biology and crystallization communications.

Carbonic Anhydrases and Their Biotechnological Applications

C. D. Boone, R. McKenna, Sonika Gill, 2013, Biomolecules.

Synchrotron Radiation Provides a Plausible Explanation for the Generation of a Free Radical Adduct of Thioxolone in Mutant Carbonic Anhydrase II.

R. McKenna, L. Govindasamy, M. Agbandje-McKenna, 2010, The journal of physical chemistry letters.

High-resolution structure of human carbonic anhydrase II complexed with acetazolamide reveals insights into inhibitor drug design.

R. McKenna, M. Agbandje-McKenna, K. Sippel, 2009, Acta crystallographica. Section F, Structural biology and crystallization communications.

Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose.

C. Supuran, R. McKenna, A. Murray, 2018, ACS medicinal chemistry letters.

Carbonic Anhydrase III

R. McKenna, B. Mahon, 2015 .

Carbonic Anhydrases (α‐Class)

R. McKenna, D. Duda, David M. Duda, 2006 .

Structural comparison of protiated, H/D-exchanged and deuterated human carbonic anhydrase IX

R. McKenna, S. Z. Fisher, B. Mahon, 2019, Acta crystallographica. Section D, Structural biology.

AAV6 K531 serves a dual function in selective receptor and antibody ADK6 recognition.

R. Samulski, R. McKenna, M. Agbandje-McKenna, 2018, Virology.

High-Resolution Structural Characterization of a New Adeno-associated Virus Serotype 5 Antibody Epitope toward Engineering Antibody-Resistant Recombinant Gene Delivery Vectors

J. Chiorini, R. McKenna, M. Agbandje-McKenna, 2018, Journal of Virology.

Mapping Antigenic Epitopes on the Human Bocavirus Capsid

R. McKenna, A. Zvirbliene, M. Agbandje-McKenna, 2016, Journal of Virology.

Adeno-Associated Virus Serotype 1 (AAV1)- and AAV5-Antibody Complex Structures Reveal Evolutionary Commonalities in Parvovirus Antigenic Reactivity

T. Baker, J. Chiorini, N. Muzyczka, 2014, Journal of Virology.

Structure and dynamics of Adeno-Associated Virus 1 serotype 1 VP 1-unique N-terminal domain and its role in 2 capsid trafficking

Antonette, R. Samulski, N. Muzyczka, 2013 .

Carbonic anhydrase II in complex with carboxylic acid-based inhibitors.

R. McKenna, C. Lomelino, 2019, Acta crystallographica. Section F, Structural biology communications.

Kinetic and crystallographic studies of the role of tyrosine 7 in the active site of human carbonic anhydrase II.

D. Silverman, R. McKenna, C. Tu, 2011, Archives of biochemistry and biophysics.

Lactate flux in astrocytes is enhanced by a non‐catalytic action of carbonic anhydrase II

R. McKenna, G. Wennemuth, J. Deitmer, 2012, The Journal of physiology.

CAIX forms a transport metabolon with monocarboxylate transporters in human breast cancer cells

R. McKenna, H. Becker, J. Andring, 2019, bioRxiv.

Substrate-dependent Interference of Carbonic Anhydrases with the Glutamine Transporter SNAT3-Induced Conductance

R. McKenna, J. Deitmer, H. Schneider, 2011, Cellular Physiology and Biochemistry.

Analysis of the single-stranded DNA bacteriophage phi X174, refined at a resolution of 3.0 A.

M. Rossmann, R. McKenna, L. Ilag, 1994, Journal of molecular biology.

Confirmation of the severe phenotypic effect of serine at codon 41 of the superoxide dismutase 1 gene

T. Siddique, T. Ashizawa, R. McKenna, 2011, Muscle & nerve.

Structural elucidation of the hormonal inhibition mechanism of the bile acid cholate on human carbonic anhydrase II.

C. D. Boone, R. McKenna, C. Tu, 2014, Acta crystallographica. Section D, Biological crystallography.

Preliminary X-ray crystallographic analysis of glutathione transferase zeta 1 (GSTZ1a-1a).

C. D. Boone, R. McKenna, M. James, 2014, Acta crystallographica. Section F, Structural biology communications.

Enzymes for carbon sequestration: neutron crystallographic studies of carbonic anhydrase.

D. Silverman, R. McKenna, M. Mustyakimov, 2010, Acta crystallographica. Section D, Biological crystallography.

Structural Studies of Adeno-Associated Virus Serotype 8 Capsid Transitions Associated with Endosomal Trafﬁcking (cid:1)

N. Muzyczka, R. McKenna, M. Agbandje-McKenna, 2011 .

Carbonic anhydrase II does not exhibit Nitrite reductase or Nitrous Anhydrase Activity

D. Silverman, R. McKenna, E. Swenson, 2018, Free radical biology & medicine.

Comparison of solution and crystal properties of Co(II)-substituted human carbonic anhydrase II.

D. Tanner, D. Silverman, R. McKenna, 2010, Archives of biochemistry and biophysics.

β-Carbonic anhydrases

R. McKenna, A. Murray, 2019, Carbonic Anhydrases.

Structural and kinetic effects on changes in the CO(2) binding pocket of human carbonic anhydrase II.

Chae Un Kim, D. Silverman, S. Gruner, 2012, Biochemistry.

Atomic Resolution Structures of Human Bufaviruses Determined by Cryo-Electron Microscopy

D. Sousa, R. McKenna, M. Agbandje-McKenna, 2018, Viruses.

Structure and mechanism of copper–carbonic anhydrase II: a nitrite reductase

Chae Un Kim, R. McKenna, J. Andring, 2020, IUCrJ.

Structural Dynamics and Activity of B19V VP1u during the pHs of Cell Entry and Endosomal Trafficking

R. McKenna, B. Bothner, M. Agbandje-McKenna, 2022, Viruses.

Identification of Aleutian Mink Disease Parvovirus Capsid Sequences Mediating Antibody-Dependent Enhancement of Infection, Virus Neutralization, and Immune Complex Formation

Richard D. Wells, R. McKenna, M. Agbandje-McKenna, 2001, Journal of Virology.

Preliminary X-ray crystallographic investigation of human parvovirus B19.

M. Rossmann, S. Kajigaya, N. Young, 1991, Virology.

Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 1.

Edward B. Miller, N. Muzyczka, R. McKenna, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

Semirational bioengineering of AAV vectors with increased potency and specificity for systemic gene therapy of muscle disorders

D. Grimm, R. McKenna, M. Agbandje-McKenna, 2022, Science advances.

Generation and characterization of anti-AAV8 and anti-AAV9 monoclonal antibodies

B. Byrne, R. McKenna, M. Agbandje-McKenna, 2017 .

Solution structure of an "open" E. coli Pol III clamp loader sliding clamp complex.

T. Matsui, T. Weiss, Farzaneh Tondnevis, 2016, Journal of structural biology.

Structures of LIG1 that engage with mutagenic mismatches inserted by polβ in base excision repair

R. McKenna, Melike Çağlayan, Qun Tang, 2022, Nature Communications.

Thermal Stability as a Determinant of AAV Serotype Identity

R. McKenna, M. Agbandje-McKenna, Bridget Lins-Austin, 2017, Molecular therapy. Methods & clinical development.

Generation and characterization of anti-Adeno-associated virus serotype 8 (AAV8) and anti-AAV9 monoclonal antibodies.

B. Byrne, R. McKenna, M. Agbandje-McKenna, 2016, Journal of virological methods.

Mapping a Neutralizing Epitope onto the Capsid of Adeno-Associated Virus Serotype 8

T. Baker, R. McKenna, N. Olson, 2012, Journal of Virology.

4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII Showing Hypoxia-Enhanced Antiproliferative Profiles.

C. Supuran, R. McKenna, C. Ghelardini, 2018, Journal of medicinal chemistry.

Human Manganese Superoxide Dismutase

D. Silverman, R. McKenna, R. Reutzel, 2006 .

Crystal structure of nitrated human manganese superoxide dismutase: mechanism of inactivation.

D. Silverman, R. McKenna, R. Reutzel, 2006, Free radical biology & medicine.

Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study.

D. Silverman, R. McKenna, L. Govindasamy, 2008, Biochemistry.

Non-Classical Inhibition of Carbonic Anhydrase

C. Supuran, R. McKenna, C. Lomelino, 2016, International journal of molecular sciences.

Biochemical and physical characterization of parvovirus minute virus of mice virus-like particles.

R. McKenna, M. Agbandje-McKenna, J. Almendral, 2000, Virology.

Structure determination of the cancer-associated Mycoplasma hyorhinis protein Mh-p37.

R. McKenna, L. Govindasamy, M. Agbandje-McKenna, 2008, Acta crystallographica. Section D, Biological crystallography.

p37 induces tumor invasiveness

S. Schuster, S. Sheng, S. Anai, 2005, Molecular Cancer Therapeutics.

Solvent-mediated proton transfer in catalysis by carbonic anhydrase.

D. Silverman, R. McKenna, 2007, Accounts of chemical research.

Neutron structure of human carbonic anhydrase II: a hydrogen-bonded water network "switch" is observed between pH 7.8 and 10.0.

D. Silverman, R. McKenna, M. Mustyakimov, 2011, Biochemistry.

Anticonvulsant/antiepileptic carbonic anhydrase inhibitors: a patent review

R. McKenna, M. Aggarwal, Bhargav Kondeti, 2013, Expert opinion on therapeutic patents.

Update on carbonic anhydrase inhibitors: a patent review (2008 – 2011)

R. McKenna, M. Aggarwal, 2012, Expert opinion on therapeutic patents.

Receptor Switching in Newly Evolved Adeno-associated Viruses

R. McKenna, M. Agbandje-McKenna, A. Asokan, 2021, Journal of virology.

Structure of neurotropic adeno-associated virus AAVrh.8.

R. McKenna, James M. Wilson, M. Agbandje-McKenna, 2015, Journal of structural biology.

Atomic structure of single-stranded DNA bacteriophage ΦX174 and its functional implications

M. Rossmann, T. Baker, R. McKenna, 1991, Nature.

Insights towards sulfonamide drug specificity in α-carbonic anhydrases.

R. McKenna, M. Aggarwal, Bhargav Kondeti, 2013, Bioorganic & medicinal chemistry.

Preliminary investigation of the phage φX174 crystal structure

M. Rossmann, T. Smith, R. McKenna, 1990 .

Transport Activity of the Sodium Bicarbonate Cotransporter NBCe1 Is Enhanced by Different Isoforms of Carbonic Anhydrase

R. McKenna, J. Deitmer, H. Becker, 2011, PloS one.

Characterization of Carbonic Anhydrase Isozyme Specific Inhibition by Sulfamated 2-Ethylestra Compounds

F. Joubert, R. McKenna, M. Agbandje-McKenna, 2011 .

Self-organizationof microtubulesandmotors

M. Rossmann, B. R. Bowman, R. McKenna, 2022 .

Crystallization and preliminary X-ray analysis of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae.

J. Clemente, J. Dame, C. Yowell, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function

R. McKenna, J. Deitmer, L. Felipe Barros, 2015, Scientific Reports.

"Seriously Sweet": Acesulfame K Exhibits Selective Inhibition Using Alternative Binding Modes in Carbonic Anhydrase Isoforms.

C. Supuran, R. McKenna, A. Murray, 2018, Journal of Medicinal Chemistry.

Apo-human carbonic anhydrase II revisited: implications of the loss of a metal in protein structure, stability, and solvent network.

M. J. Chalmers, P. Griffin, D. Silverman, 2009, Biochemistry.

Elucidation of the proton transport mechanism in human carbonic anhydrase II.

G. Voth, D. Silverman, R. McKenna, 2009, Journal of the American Chemical Society.

Entrapment of Carbon Dioxide in the Active Site of Carbonic Anhydrase II*♦

Chae Un Kim, D. Silverman, S. Gruner, 2008, Journal of Biological Chemistry.

Proton transfer from exogenous donors in catalysis by human carbonic anhydrase II.

D. Silverman, R. McKenna, C. Tu, 2005, Archives of biochemistry and biophysics.

Carbon Dioxide "Trapped" in a β-Carbonic Anhydrase.

R. McKenna, M. Pinard, M. Aggarwal, 2015, Biochemistry.

Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II.

D. Silverman, R. McKenna, M. Agbandje-McKenna, 2010, Biochemistry.

Effect of active-site mutation at Asn67 on the proton transfer mechanism of human carbonic anhydrase II.

G. Voth, D. Silverman, R. McKenna, 2009, Biochemistry.

Speeding up proton transfer in a fast enzyme: kinetic and crystallographic studies on the effect of hydrophobic amino acid substitutions in the active site of human carbonic anhydrase II.

D. Silverman, R. McKenna, L. Govindasamy, 2007, Biochemistry.

Proton transfer in a Thr200His mutant of human carbonic anhydrase II

D. Silverman, R. McKenna, S. Z. Fisher, 2005, Proteins.

Human carbonic anhydrase III: structural and kinetic study of catalysis and proton transfer.

D. Silverman, P. Laipis, R. McKenna, 2005, Biochemistry.

Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II.

D. Silverman, R. McKenna, L. Govindasamy, 2005, Biochemistry.

Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases.

C. Supuran, R. McKenna, C. Ghelardini, 2017, ACS medicinal chemistry letters.

Crystallography and Its Impact on Carbonic Anhydrase Research

R. McKenna, C. Lomelino, J. Andring, 2018, International journal of medicinal chemistry.

Structural and catalytic characterization of a thermally stable and acid-stable variant of human carbonic anhydrase II containing an engineered disulfide bond.

C. D. Boone, D. Silverman, R. McKenna, 2013, Acta crystallographica. Section D, Biological crystallography.

Neutron diffraction of acetazolamide-bound human carbonic anhydrase II reveals atomic details of drug binding.

D. Silverman, R. McKenna, S. Z. Fisher, 2012, Journal of the American Chemical Society.

Acta Crystallographica Section D Biological

Vincent B. Chen, Ian W. Davis, Gary J. Kapral, 2001 .

Comparative Structural, Biophysical, and Receptor Binding Study of True Type and Wild type AAV2.

D. Sousa, R. McKenna, E. Henckaerts, 2021, Journal of structural biology.

Analysis of the Binding Moiety Mediating the Interaction between Monocarboxylate Transporters and Carbonic Anhydrase II*

C. D. Boone, R. McKenna, J. Deitmer, 2015, The Journal of Biological Chemistry.

Parvovirus Capsid Structures Required for Infection: Mutations Controlling Receptor Recognition and Protease Cleavages

Donald W. Lee, R. McKenna, S. Hafenstein, 2016, Journal of Virology.

Capsid Structure of Aleutian Mink Disease Virus and Human Parvovirus 4: New Faces in the Parvovirus Family Portrait

R. McKenna, J. Qiu, M. Söderlund-Venermo, 2022, Viruses.

Structural Insights into Human Bocaparvoviruses

D. Sousa, T. Baker, R. McKenna, 2017, Journal of Virology.

Structures of LIG1 engaging with mutagenic mismatches inserted by polβ in base excision repair

R. McKenna, Melike Çağlayan, Qun Tang, 2022, bioRxiv.

Structurally Mapping Antigenic Epitopes of Adeno-associated Virus 9: Development of Antibody Escape Variants

R. McKenna, M. Agbandje-McKenna, A. Asokan, 2021, Journal of virology.

Characterization of AAV-Specific Affinity Ligands: Consequences for Vector Purification and Development Strategies

R. McKenna, M. Agbandje-McKenna, P. Chipman, 2020, Molecular therapy. Methods & clinical development.

The structure of AAVrh32.33, a novel gene delivery vector.

R. McKenna, James M. Wilson, M. Agbandje-McKenna, 2014, Journal of structural biology.

Vaccinia Virus a Putative Hub Protein Expressed by Biochemical and Biophysical Properties of Microbiology

R. Condit, R. McKenna, Balasubramanian Venkatakrishnan, 2013 .

Capsid Antibodies to Different Adeno-Associated Virus Serotypes Bind Common Regions

Edward B. Miller, R. Samulski, T. Baker, 2013, Journal of Virology.

Structural Characterization of the Dual Glycan Binding Adeno-Associated Virus Serotype 6

Kristin N. Parent, R. Samulski, K. Parent, 2010, Journal of Virology.

pH-Induced Conformational Changes of Human Bocavirus Capsids

D. Sousa, R. McKenna, M. Agbandje-McKenna, 2021, Journal of Virology.

Characterization of the GBoV1 Capsid and Its Antibody Interactions

D. Grimm, R. McKenna, A. Zvirbliene, 2021, Viruses.

Sub-2 Å Ewald Curvature Corrected Single-Particle Cryo-EM

Yong Zi Tan, J. Grieger, R. Samulski, 2018, bioRxiv.

Assembly and disassembly intermediates of maize streak geminivirus.

R. McKenna, M. Agbandje-McKenna, A. Bennett, 2018, Virology.

Elucidating the role of metal ions in carbonic anhydrase catalysis

Chae Un Kim, C. Ghim, R. McKenna, 2020, Nature Communications.

Assembly and structural analysis of a covalently closed nano-scale DNA cage

Felicie F. Andersen, B. Guldbrandtsen, B. Knudsen, 2007, Nucleic acids research.

Chemical rescue of enzymes: proton transfer in mutants of human carbonic anhydrase II.

Gregory A Voth, C Mark Maupin, Norberto Castillo, 2011, Journal of the American Chemical Society.

Structural insights and functional implications of choline acetyltransferase.

R. McKenna, L. Govindasamy, M. Agbandje-McKenna, 2004, Journal of structural biology.

Atomic Resolution Structure of the Oncolytic Parvovirus LuIII by Electron Microscopy and 3D Image Reconstruction

T. Baker, R. McKenna, M. Agbandje-McKenna, 2017, Viruses.

Structural Characterization of H-1 Parvovirus: Comparison of Infectious Virions to Empty Capsids

R. McKenna, L. Govindasamy, M. Agbandje-McKenna, 2013, Journal of Virology.

Parvovirus capsid structures required for infection : mutations controlling receptor 1 recognition and protease cleavages 2 3 4

Donald W. Lee, R. McKenna, S. Hafenstein, 2016 .

The Role of Select Subtype Polymorphisms on HIV-1 Protease Conformational Sampling and Dynamics*

Carlos Simmerling, C. D. Boone, Michael Bieri, 2014, The Journal of Biological Chemistry.

Molecular modeling of the rabbit colonic (HKα2a) H+, K+ ATPase

R. McKenna, D. Duda, B. Cain, 2003 .

Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III

D. Silverman, P. Laipis, R. McKenna, 2007, Proteins.

Structural Rearrangements in R432A Variant of AAV2 Affect Genome Packaging

T. Baker, G. Cardone, N. Muzyczka, 2016, Microscopy and Microanalysis.

Effects of cryoprotectants on the structure and thermostability of the human carbonic anhydrase II-acetazolamide complex.

C. D. Boone, D. Silverman, R. McKenna, 2013, Acta crystallographica. Section D, Biological crystallography.

Kinetic Analysis of Multiple Proton Shuttles in the Active Site of Human Carbonic Anhydrase*

D. Silverman, P. Laipis, R. McKenna, 2002, The Journal of Biological Chemistry.

Role of Trp19 and Tyr200 in catalysis by the γ-class carbonic anhydrase from Methanosarcina thermophila.

D. Silverman, R. McKenna, J. Ferry, 2013, Archives of biochemistry and biophysics.

Virus Serotype 5 Structural Insights into Adeno-Associated

J. Chiorini, N. Muzyczka, R. McKenna, 2014 .

Structural Insights into Adeno-Associated Virus Serotype 5

J. Chiorini, N. Muzyczka, R. McKenna, 2013, Journal of Virology.

Protein Degradation by Gammaherpesvirus RTAs: More Than Just Viral Transactivators

R. McKenna, Z. Tóth, J. Combs, 2023, Viruses.

Structural analysis of the Spiroplasma virus, SpV4: implications for evolutionary variation to obtain host diversity among the Microviridae.

T. Baker, R. McKenna, M. Agbandje-McKenna, 1998, Structure.

Insights into Mycoplasma genitalium metabolism revealed by the structure of MG289, an extracytoplasmic thiamine binding lipoprotein

Steve Goodison, Robert McKenna, Banumathi Sankaran, 2011, Proteins.

Structure of Human Carnitine Acetyltransferase

R. McKenna, L. Govindasamy, M. Agbandje-McKenna, 2003, The Journal of Biological Chemistry.

Crystallization and preliminary X-ray crystallographic studies on recombinant human carnitine acetyltransferase.

R. McKenna, L. Govindasamy, M. Agbandje-McKenna, 2002, Acta crystallographica. Section D, Biological crystallography.

Structural insights into the effect of active-site mutation on the catalytic mechanism of carbonic anhydrase

Chae Un Kim, R. McKenna, A. Adhikari, 2020, IUCrJ.

Tracking solvent and protein movement during CO2 release in carbonic anhydrase II crystals

Chae Un Kim, S. Gruner, SangYoun Park, 2016, Proceedings of the National Academy of Sciences.

Structure and Dynamics of Adeno-Associated Virus Serotype 1 VP1-Unique N-Terminal Domain and Its Role in Capsid Trafficking

R. Samulski, N. Muzyczka, R. McKenna, 2013, Journal of Virology.

Atomic structure of the degraded procapsid particle of the bacteriophage G4: induced structural changes in the presence of calcium ions and functional implications.

M. Rossmann, B. R. Bowman, R. McKenna, 1996, Journal of molecular biology.

The Escherichia coli Clamp Loader Can Actively Pry Open the β-Sliding Clamp

Jennifer A. Thompson, M. O’Donnell, R. McKenna, 2011, The Journal of Biological Chemistry.

Defective Hydrophobic Sliding Mechanism and Active Site Expansion in HIV-1 Protease Drug Resistant Variant Gly48Thr/Leu89Met: Mechanisms for the Loss of Saquinavir Binding Potency

Shyamasri Biswas, Adrian Roitberg, Ben M. Dunn, 2014, Biochemistry.

Mining the Protein Data Bank to Differentiate Error from Structural Variation in Clustered Static Structures: An Examination of HIV Protease

R. McKenna, M. Agbandje-McKenna, Balasubramanian Venkatakrishnan, 2012, Viruses.

Host-Selected Amino Acid Changes at the Sialic Acid Binding Pocket of the Parvovirus Capsid Modulate Cell Binding Affinity and Determine Virulence

R. McKenna, M. Agbandje-McKenna, J. Almendral, 2006, Journal of Virology.

Deep Analysis of Residue Constraints (DARC): identifying determinants of protein functional specificity

S. Altschul, A. F. Neuwald, Farzaneh Tondnevis, 2020, Scientific Reports.

Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties.

Wengang Cao, D. Silverman, R. McKenna, 2009, Biochemistry.

Polylysine Induces an Antiparallel Actin Dimer That Nucleates Filament Assembly

Steven C Almo, Michael S Chapman, Robert McKenna, 2002, The Journal of Biological Chemistry.

Solution study of the Escherichia coli DNA polymerase III clamp loader reveals the location of the dynamic ψχ heterodimer

R. Gillilan, Farzaneh Tondnevis, R. McKenna, 2015, Structural dynamics.

Expression, purification, kinetic, and structural characterization of an alpha-class carbonic anhydrase from Aedes aegypti (AaCA1).

D. Silverman, R. McKenna, S. Z. Fisher, 2006, Biochimica et biophysica acta.

Improved Genome Packaging Efficiency of Adeno-associated Virus Vectors Using Rep Hybrids

R. McKenna, M. Agbandje-McKenna, P. Chipman, 2021, Journal of virology.

Improved Genome Packaging Efficiency of AAV Vectors Using Rep Hybrids

R. McKenna, M. Agbandje-McKenna, P. Chipman, 2021, bioRxiv.

Structure of Adeno-Associated Virus Serotype 8, a Gene Therapy Vector

B. Byrne, N. Muzyczka, R. McKenna, 2007, Journal of Virology.

Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 4.

J. Chiorini, R. McKenna, L. Govindasamy, 2003, Virology.

Cloning, expression, purification, crystallization and preliminary X-ray analysis of Mycoplasma genitalium protein MG289.

R. McKenna, M. Agbandje-McKenna, C. Rosser, 2009, Acta crystallographica. Section F, Structural biology and crystallization communications.

The contribution of naturally occurring polymorphisms in altering the biochemical and structural characteristics of HIV-1 subtype C protease.

B. Dunn, R. McKenna, M. Goodenow, 2008, Biochemistry.

Structure of a viral procapsid with molecular scaffolding

Michael G. Rossmann, Robert McKenna, Leodevico L. Ilag, 1997, Nature.

DNA packaging intermediates of bacteriophage φX174.

M. Rossmann, T. Baker, R. McKenna, 1995, Structure.

Adeno-associated Virus 9 Structural Rearrangements Induced by Endosomal Trafficking pH and Glycan Attachment

Rick Huang, R. McKenna, M. Agbandje-McKenna, 2021, Journal of virology.

Three-Dimensional Structure of Aleutian Mink Disease Parvovirus: Implications for Disease Pathogenicity

T. Baker, R. McKenna, N. Olson, 1999, Journal of Virology.

Neutron protein crystallography reveals unique details of clinical drug binding to a human target enzyme

D. Silverman, R. McKenna, A. Kovalevsky, 2013 .

Production, purification, crystallization and structure determination of H-1 Parvovirus.

R. McKenna, L. Govindasamy, M. Agbandje-McKenna, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

A Comparative Analysis of the Structural Architecture of ssDNA Viruses

R. McKenna, M. Agbandje-McKenna, A. Bennett, 2008 .

Isolation and characterization of subgenomic DNAs encapsidated in "single" T = 1 isometric particles of Maize streak virus.

R. McKenna, M. Agbandje-McKenna, E. Padron, 2004, Virology.

Crystallization and preliminary X-ray crystallographic studies on recombinant rat choline acetyltransferase.

R. McKenna, L. Govindasamy, M. Agbandje-McKenna, 2004, Acta crystallographica. Section D, Biological crystallography.

Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 9.

B. Byrne, N. Muzyczka, R. McKenna, 2009, Acta crystallographica. Section F, Structural biology and crystallization communications.

Heparin binding induces conformational changes in Adeno-associated virus serotype 2.

T. Baker, N. Muzyczka, R. McKenna, 2009, Journal of structural biology.

Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 7.

N. Muzyczka, R. McKenna, L. Govindasamy, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Electronic Reprint Structural Biology and Crystallization Communications Production, Purification, Crystallization and Preliminary X-ray Structural Studies of Adeno-associated Virus Serotype 5 Structural Biology and Crystallization Communications Production, Purification, Crystallization and Prelimi

J. Chiorini, N. Muzyczka, R. McKenna, 2022 .

Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution*

Lingna Hu, Linh Pham, Robert McKenna, 2016, The Journal of Biological Chemistry.

Use of Non-Crystallographic Symmetry for Ab Initio Phasing of Virus Structures

John E. Johnson, M. S. Chapman, M. Rossmann, 1998 .

Characterization of an intermolecular quaternary interaction between discrete segments of the Streptococcus mutans adhesin P1 by NMR spectroscopy

R. McKenna, M. Agbandje-McKenna, L. Brady, 2019, The FEBS journal.

Neutron structure of human carbonic anhydrase II in complex with methazolamide: mapping the solvent and hydrogen-bonding patterns of an effective clinical drug

Jeremy C. Smith, Hector A Velazquez, R. McKenna, 2016, IUCrJ.

Structural and Biophysical Analysis of Adeno-Associated Virus Serotype 2 Capsid Assembly Variants

N. Muzyczka, R. McKenna, M. Agbandje-McKenna, 2023, Journal of virology.

Structure of human salivary alpha-amylase crystallized in a C-centered monoclinic space group.

D. Silverman, R. McKenna, L. Govindasamy, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

Comparative Analysis of the Capsid Structures of AAVrh.10, AAVrh.39, and AAV8

D. Sousa, R. McKenna, M. Agbandje-McKenna, 2019, Journal of Virology.

Industrial CO 2 Removal Using Carbonic Anhydrase: Potential, Promise and

R. McKenna, C. Mahon, 2015 .

Structural Determinants of Tissue Tropism and In Vivo Pathogenicity for the Parvovirus Minute Virus of Mice

Maria Kontou, Robert McKenna, R. McKenna, 2005, Journal of Virology.

Neutron crystallographic studies of carbonic anhydrase.

R. McKenna, J. Andring, J. Combs, 2020, Methods in enzymology.

Chemical rescue in catalysis by human carbonic anhydrases II and III.

D. Silverman, P. Laipis, R. McKenna, 2002, Biochemistry.

Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase.

R. McKenna, L. Govindasamy, M. Agbandje-McKenna, 2004, Journal of structural biology.

Microbatch Mixing: “Shaken not Stirred”, a Method for Macromolecular Microcrystal Production for Serial Crystallography

Ian R. Smith, R. McKenna, M. Agbandje-McKenna, 2016 .

Structural and kinetic analysis of the chemical rescue of the proton transfer function of carbonic anhydrase II.

D. Silverman, P. Laipis, R. McKenna, 2001, Biochemistry.

Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease.

Maureen M Goodenow, Robert McKenna, J. Clemente, 2004, Biochemistry.

Structural and catalytic effects of proline substitution and surface loop deletion in the extended active site of human carbonic anhydrase II

C. D. Boone, R. McKenna, C. Tu, 2015, The FEBS journal.

A Single Surface-Exposed Amino Acid Determines Differential Neutralization of AAV1 and AAV6 by Human Alpha-Defensins

Jason G. Smith, R. McKenna, A. Bennett, 2023, Journal of virology.

Structural characterization of an envelope-associated adeno-associated virus type 2 capsid.

R. McKenna, P. Chipman, M. Mietzsch, 2021, Virology.

Atomic structure of a rationally engineered gene delivery vector, AAV2.5.

B. Byrne, D. Sousa, R. McKenna, 2018, Journal of structural biology.

Structural characterization of a bat Adeno-associated virus capsid.

R. McKenna, M. Agbandje-McKenna, P. Chipman, 2020, Journal of structural biology.

Structural Characterization of Cuta- and Tusavirus: Insight into Protoparvoviruses Capsid Morphology

David F. Smith, Yi Lasanajak, R. McKenna, 2020, Viruses.

Analysis of HIV-1 CRF_01 A/E protease inhibitor resistance: structural determinants for maintaining sensitivity and developing resistance to atazanavir.

Maureen M Goodenow, Robert McKenna, J. Clemente, 2006, Biochemistry.

Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor.

Tooru Kimura, Yoshio Hayashi, Robert McKenna, 2006, Acta crystallographica. Section D, Biological crystallography.

Structural Biology and Crystallization Communications Production, Purification, Crystallization and Preliminary X-ray Analysis of Adeno-associated Virus Serotype 8

B. Byrne, N. Muzyczka, R. McKenna, 2022 .

Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles

D. Silverman, R. McKenna, C. M. Maupin, 2014, IUCrJ.

Atomic crystal and molecular dynamics simulation structures of human carbonic anhydrase II: insights into the proton transfer mechanism.

G. Voth, D. Silverman, R. McKenna, 2007, Biochemistry.

Bipartite genome and structural organization of the parvovirus Acheta domesticus segmented densovirus

R. McKenna, Emmanuel W Smith, P. Tijssen, 2023, Nature communications.

Structural and molecular biology of Acheta domesticus segmented densovirus, the first parvovirus to harbor a bipartite genome

R. McKenna, Emmanuel W Smith, P. Tijssen, 2022, bioRxiv.

Production and characterization of an AAV1-VP3-only capsid: An analytical benchmark standard

Ke Ma, R. McKenna, M. Mietzsch, 2023, Molecular therapy. Methods & clinical development.

Structural Study of Aavrh.10 Receptor and Antibody Interactions

R. Linhardt, R. Heilbronn, R. McKenna, 2021, Journal of virology.

Crystallographic evidence for noncoplanar catalytic aspartic acids in plasmepsin II resides in the Protein Data Bank.

B. Dunn, R. McKenna, M. Agbandje-McKenna, 2009, Acta crystallographica. Section D, Biological crystallography.

Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II.

D. Silverman, R. McKenna, M. Agbandje-McKenna, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

Observed surface lysine acetylation of human carbonic anhydrase II expressed in Escherichia coli

R. McKenna, B. Mahon, M. Pinard, 2015, Protein science : a publication of the Protein Society.

X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes

D. Silverman, R. McKenna, L. Govindasamy, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystallization and preliminary X-ray analysis of human carbonic anhydrase III.

D. Silverman, R. McKenna, L. Govindasamy, 2002, Acta crystallographica. Section D, Biological crystallography.

Location of binding sites in small molecule rescue of human carbonic anhydrase II.

Robert McKenna, D. Silverman, R. McKenna, 2007, Biophysical journal.

A short, strong hydrogen bond in the active site of human carbonic anhydrase II.

Chae Un Kim, D. Silverman, S. Gruner, 2010, Biochemistry.

Structural Characterization of Canine Minute Virus, Rat and Porcine Bocavirus

R. McKenna, M. Mietzsch, P. Chipman, 2023, Viruses.

Calcium Ion-induced Structural Changes in Bacteriophage φ X174

M. Rossmann, R. McKenna, L. Ilag, 1994 .

Calcium ion-induced structural changes in bacteriophage phi X174.

M. Rossmann, R. McKenna, L. Ilag, 1994, Journal of molecular biology.

Expression, purification and preliminary X-ray crystallographic studies of the human immunodeficiency virus 1 subtype C protease.

B. Dunn, R. McKenna, M. Goodenow, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Localization and Membrane Topology of Coronavirus Nonstructural Protein 4: Involvement of the Early Secretory Pathway in Replication

D. Hazuda, B. Cullen, N. DeLuca, 2007, Journal of Virology.

Strong Hydrogen Bond in the Active Site of Human Carbonic Anhydrase II † , ‡

Chae Un Kim, D. Silverman, S. Gruner, 2009 .

The refined atomic structure of carbonic anhydrase II at 1.05 A resolution: implications of chemical rescue of proton transfer.

D. Silverman, R. McKenna, L. Govindasamy, 2003, Acta crystallographica. Section D, Biological crystallography.

Evidence for pH-Dependent Protease Activity in the Adeno-Associated Virus Capsid

N. Muzyczka, R. McKenna, M. Agbandje-McKenna, 2012, Journal of Virology.

Aspirin: A Suicide Inhibitor of Carbonic Anhydrase II

R. McKenna, J. Andring, J. Combs, 2020, Biomolecules.

Sub-2 Å Ewald curvature corrected structure of an AAV2 capsid variant

Yong Zi Tan, J. Grieger, R. Samulski, 2018, Nature Communications.

Profiling of Glycan Receptors for Minute Virus of Mice in Permissive Cell Lines Towards Understanding the Mechanism of Cell Recognition

David F. Smith, R. Cummings, A. Dell, 2014, PLoS ONE.

Structure of human salivary α‐amylase crystallized in a C‐centered monoclinic space group

D. Silverman, R. McKenna, L. Govindasamy, 2006 .

Structural Insights into Adeno-Associated Virus Serotype 5

J. Chiorini, N. Muzyczka, R. McKenna, 2013, Journal of Virology.

Lactate flux in astrocytes is enhanced by a non‐catalytic action of carbonic anhydrase II

R. McKenna, G. Wennemuth, J. Deitmer, 2012, The Journal of physiology.

Structural and functional characterization of capsid binding by anti-AAV9 monoclonal antibodies from infants after SMA gene therapy.

I. Alexander, R. McKenna, J. Reed, 2023, Molecular Therapy.

Insights into Mycoplasma genitalium metabolism revealed by the structure of MG289, an extracytoplasmic thiamine binding lipoprotein

B. Sankaran, S. Goodison, R. McKenna, 2011, Proteins.

Human Carbonic Anhydrase III: Structural and Kinetic Study of Catalysis and

D. Silverman, P. Laipis, R. McKenna, 2005 .

The structure of AAVrh32.33, a novel gene delivery vector.

R. McKenna, James M. Wilson, M. Agbandje-McKenna, 2014, Journal of structural biology.

Crystallographic evidence for noncoplanar catalytic aspartic acids in plasmepsin II resides in the Protein Data Bank.

B. Dunn, R. McKenna, M. Agbandje-McKenna, 2009, Acta crystallographica. Section D, Biological crystallography.

Analysis of the Binding Moiety Mediating the Interaction between Monocarboxylate Transporters and Carbonic Anhydrase II*

C. D. Boone, R. McKenna, J. Deitmer, 2015, The Journal of Biological Chemistry.

Development of new adeno-associated virus capsid variants for targeted gene delivery to human cardiomyocytes

E. Kizana, I. Alexander, R. McKenna, 2023, Molecular therapy. Methods & clinical development.

A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX.

R. McKenna, C. Tu, B. Mahon, 2015, Acta crystallographica. Section F, Structural biology communications.

Analysis of the AAVrh. 10 Capsid Structure and Its Antigenic and Receptor Interactions

R. Crystal, T. Baker, G. Cardone, 2017 .

Actin crystal dynamics: structural implications for F-actin nucleation, polymerization, and branching mediated by the anti-parallel dimer.

R. McKenna, L. Govindasamy, C. Yoshioka, 2003, Journal of structural biology.