J. Maher

发表

Computational experiments reveal plausible mechanisms for changing patterns of hepatic zonation of xenobiotic clearance and hepatotoxicity.

S. Sheikh-Bahaei, J. Maher, C. Anthony Hunt, 2010, Journal of theoretical biology.

Metabolic profiling of livers and blood from obese Zucker rats.

Ryutaro Hirose, Matthew Jackman, R. Hirose, 2006, Journal of hepatology.

Impaired Dexamethasone-Mediated Induction of Tryptophan 2,3-Dioxygenase in Heme-Deficient Rat Hepatocytes: Translational Control by a Hepatic eIF2α Kinase, the Heme-Regulated Inhibitor

K. Medzihradszky, J. Maher, D. Maltby, 2007, Journal of Pharmacology and Experimental Therapeutics.

Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver.

J. Maher, D. Bissell, D. Arenson, 1987, The Journal of clinical investigation.

Characterization of the physiological turnover of native and inactivated cytochromes P450 3A in cultured rat hepatocytes: a role for the cytosolic AAA ATPase p97?

K. Medzihradszky, J. Maher, M. Correia, 2007, Biochemistry.

VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis

Kevin Wei, S. Schrier, Betty Y. Y. Tam, 2006, Nature Medicine.

Anti-Fas Induces Hepatic Chemokines and Promotes Inflammation by an NF-κB-independent, Caspase-3-dependent Pathway*

J. Maher, R. Rippe, L. Schrum, 2001, The Journal of Biological Chemistry.

HEME-REVERSIBLE IMPAIRMENT OF CYP2B1/2 INDUCTION IN HEME DEPLETED RAT HEPATOCYTES IN PRIMARY CULTURE : TRANSLATIONAL CONTROL BY A HEPATIC eIF2α KINASE?

J. Maher, M. Correia, C. Hefner, 2005 .

Heme-Reversible Impairment of CYP2B1/2 Induction in Heme-Depleted Rat Hepatocytes in Primary Culture: Translational Control by a Hepatic α-Subunit of the Eukaryotic Initiation Factor Kinase?

J. Maher, M. Correia, C. Hefner, 2005, Journal of Pharmacology and Experimental Therapeutics.

Diagnosis of hepatic encephalopathy: Will in vivo proton MRS play a role?

P. Hayes, J. Wardlaw, R. Jalan, 1999, Hepatology.

DAMPs ramp up drug toxicity.

J. Maher, 2009, The Journal of clinical investigation.

Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis

J. Maher, J. Ryan, P. Leon, 2008, Hepatology.

Blocking the Secretion of Hepatic Very Low Density Lipoproteins Renders the Liver More Susceptible to Toxin-induced Injury*

J. Björkegren, M. Bergo, S. Young, 2002, The Journal of Biological Chemistry.

Immunolocalization of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocytes in primary culture.

S. Friedman, J. Maher, D. Bissell, 1988, Gastroenterology.

Adenovirus‐mediated expression of cytokine‐induced neutrophil chemoattractant in rat liver induces a neutrophilic hepatitis

J. Maher, M. Burton, M. Burton, 1997, Hepatology.

Polyunsaturated fat in the methionine-choline-deficient diet influences hepatic inflammation but not hepatocellular injury 1 s⃞ Published, JLR Papers in Press, May 27, 2007.

S. Kakar, J. Maher, Gene S Lee, 2007, Journal of Lipid Research.

Macronutrients and the Adipose-Liver Axis in Obesity and Fatty Liver

J. Maher, Caroline C. Duwaerts, 2019, Cellular and molecular gastroenterology and hepatology.

Hospitalizations for Autoimmune Hepatitis Disproportionately Affect Black and Latino Americans

J. Maher, M. Kohn, R. Wong, 2018, The American Journal of Gastroenterology.

Comparison of surrogate and direct measurement of insulin resistance in chronic hepatitis C virus infection: Impact of obesity and ethnicity

G. Reaven, P. Bacchetti, J. Maher, 2010, Hepatology.

Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo.

R. F. McGuire, J. Maher, Richard F. McGuire, 1990, The Journal of clinical investigation.

Cell-matrix interactions in liver.

J. Maher, D. Bissell, D. Bissell, 1993, Seminars in cell biology.

Impact of Insulin Resistance on HCV Treatment Response and Impact of HCV Treatment on Insulin Sensitivity Using Direct Measurements of Insulin Action

P. Bacchetti, J. Maher, D. Brandman, 2012, Diabetes Care.

Trunk fat as a determinant of liver disease.

J. Maher, 2010, Gastroenterology.

Lipids in liver disease: looking beyond steatosis.

R. Schwabe, J. Maher, 2012, Gastroenterology.

Visceral Adipose Tissue Inflammation and Radiographic Visceral-to-Subcutaneous Adipose Tissue Ratio in Patients with Cirrhosis

J. Maher, J. Lai, Soo-Jin Cho, 2021, Digestive Diseases and Sciences.

Malondialdehyde stimulates collagen production by hepatic lipocytes only upon activation in primary culture.

J. Maher, C. Tzagarakis, A. Giménez, 1994, Alcohol and alcoholism.

Retinol binding protein 4 and fatty liver: A direct link?

J. Maher, 2013, Hepatology.

Primary hepatocyte culture: Is it home away from home?

J. Maher, 1988, Hepatology.

Leukocytes as modulators of stellate cell activation.

J. Maher, 1999, Alcoholism, clinical and experimental research.

Stress signaling in the methionine-choline-deficient model of murine fatty liver disease.

J. Maher, J. Grenert, Jim S Yan, 2010, Gastroenterology.

Specific bile acids inhibit hepatic fatty acid uptake in mice

B. M. Forman, J. Maher, H. Park, 2012, Hepatology.

The basic helix‐loop‐helix transcription factor, heart and neural crest derivatives expressed transcript 2, marks hepatic stellate cells in zebrafish: Analysis of stellate cell entry into the developing liver

D. Stainier, K. Evason, J. Maher, 2012, Hepatology.

Rat hepatic stellate cells produce cytokine-induced neutrophil chemoattractant in culture and in vivo.

J. Maher, J. Lozier, M. Scott, 1998, American journal of physiology. Gastrointestinal and liver physiology.

Rat hepatic stellate cells produce cytokine-induced neutrophil chemoattractant in culture and in vivo.

J. Maher, J. Lozier, M. Scott, 1998, The American journal of physiology.

Glutathione regulation in rat hepatic stellate cells. Comparative studies in primary culture and in liver injury in vivo.

B. Neuschwander‐Tetri, J. Maher, J. Saito, 1997, Biochemical pharmacology.

Parenchymal and Nonparenchymal Cell Interactions in the Liver

S. Friedman, J. Maher, 1993, Seminars in liver disease.

Differential hepatotoxicity of dietary and DNL-derived palmitate in the methionine-choline-deficient model of steatohepatitis

J. Maher, J. Grenert, Andrew A. Pierce, 2015, BMC Gastroenterology.

Transgenic overexpression of interleukin-8 in mouse liver protects against galactosamine/endotoxin toxicity.

J. Maher, Gene S Lee, Jim S Yan, 2006, Journal of hepatology.

Doxycycline Significantly Enhances Induction of Induced Pluripotent Stem Cells to Endoderm by Enhancing Survival Through Protein Kinase B Phosphorylation

Julie B. Sneddon, M. Medina, J. Maher, 2021 .

Hepatic Fibrosis Caused by Alcohol

J. Maher, 1990, Seminars in liver disease.

Race/ethnicity is an independent risk factor for autoimmune hepatitis among the San Francisco underserved

J. Maher, J. Sewell, R. Wong, 2018, Autoimmunity.

How does estrogen enhance endotoxin toxicity? let me count the ways

J. Maher, 1998, Hepatology.

Limited role for CXC chemokines in the pathogenesis of alpha-naphthylisothiocyanate-induced liver injury.

J. Maher, Gene S Lee, J. Vierling, 2004, American journal of physiology. Gastrointestinal and liver physiology.

Infiltrating neutrophils in bile duct-ligated livers do not promote hepatic fibrosis.

J. Maher, C. Campe, J. Saito, 2003, Hepatology research : the official journal of the Japan Society of Hepatology.

The Role of STING in Liver Injury Is Both Stimulus- and Time-Dependent

J. Maher, Dounia Le Guillou, Caroline C. Duwaerts, 2022, Nutrients.

Macrophages Steal STING From the Infectious Disease Playbook to Promote Nonalcoholic Fatty Liver Disease.

J. Maher, 2018, Gastroenterology.

Bile duct ligation in rats induces biliary expression of cytokine-induced neutrophil chemoattractant.

J. Maher, J. Saito, 2000, Gastroenterology.

Manipulation of glutathione stores in rat hepatic stellate cells does not alter collagen synthesis

B. Neuschwander‐Tetri, J. Maher, 1997, Hepatology.

Doxycycline Significantly Enhances Induction of iPSCs to Endoderm by Enhancing survival via AKT Phosphorylation

M. Medina, J. Maher, C. Esteva‐Font, 2020, bioRxiv.

Short passive cooling protects rats during hepatectomy by inducing heat shock proteins and limiting the induction of pro-inflammatory cytokines.

R. Hirose, J. Maher, C. Niemann, 2010, The Journal of surgical research.

Mild hypothermia protects obese rats from fulminant hepatic necrosis induced by ischemia-reperfusion.

R. Hirose, N. Serkova, J. Maher, 2006, Surgery.

Apoptosis: Silent killer or neutron bomb?

J. Maher, 1998, Hepatology.

The CYP2E1 knockout delivers another punch: First ASH, now NASH

J. Maher, 2001 .

Mouse liver injury induces hepatic macrophage FGF23 production

M. Czaja, J. Maher, Francesca Cingolani, 2022, PloS one.

Dietary fructose exacerbates hepatocellular injury when incorporated into a methionine‐choline‐deficient diet

H. Ogata, J. Maher, J. Grenert, 2010, Liver international : official journal of the International Association for the Study of the Liver.

Connective tissue biology and hepatic fibrosis: Report of a conference

S. Friedman, J. Maher, D. Bissell, 1990, Hepatology.

Inhibition of rat hepatic lipocyte activation in culture by interferon‐γ

S. Friedman, D. Rockey, W. Jarnagin, 1992, Hepatology.

Treatment of alcoholic hepatitis

J. Maher, 2002, Journal of gastroenterology and hepatology.

Turnover of metallothioneins in rat liver.

J. Maher, I. Bernstein, W. Winter, 1978, The Biochemical journal.

Isolated hepatic lipocytes and kupffer cells from normal human liver: Morphological and functional characteristics in primary culture

S. Friedman, D. Rockey, J. Maher, 1992, Hepatology.

Warm Ischemia-induced Alterations in Oxidative and Inflammatory Proteins in Hepatic Kupffer Cells in Rats*

A. Burlingame, R. Hirose, J. Maher, 2006, Molecular & Cellular Proteomics.

Mechanisms and therapy of hepatic fibrosis: Report of the AASLD single topic basic research conference

S. Friedman, J. Maher, D. Bissell, 2000, Hepatology.

Acetaldehyde-induced stimulation of collagen synthesis and gene expression is dependent on conditions of cell culture: studies with rat lipocytes and fibroblasts.

J. Maher, C. Tzagarakis, S. Zia, 1994, Alcoholism, clinical and experimental research.

Partial cloning of the M subunit of laminin from adult rat lipocytes: Expression of the M subunit by cells isolated from normal and injured liver

J. Maher, C. Tzagarakis, 1994, Hepatology.

Exploring Alcohol’s Effects on Liver Function

J. Maher, 1997, Alcohol health and research world.

A screen in mice uncovers repression of lipoprotein lipase by microRNA‐29a as a mechanism for lipid distribution away from the liver

Michael T. McManus, L. Lim, Amar Deep Sharma, 2015, Hepatology.

Activation of the Met Receptor by Cell Attachment Induces and Sustains Hepatocellular Carcinomas in Transgenic Mice

L. Ferrell, J. Bishop, J. Maher, 2001, The Journal of cell biology.

Nonalcoholic fatty liver disease

V. Wong, B. Neuschwander‐Tetri, C. Sirlin, 2015, Nature Reviews Disease Primers.

OC-001 The Impact of the Introduction of Formalised Polypectomy Assessment on Training in the United Kingdom

D. Griggs, C. Betsholtz, J. Iredale, 2013, Gut.

What doesn't kill you makes you stronger: How hepatocytes survive prolonged cholestasis

J. Maher, 2004, Hepatology.

Selective αv integrin depletion identifies a core, targetable molecular pathway that regulates fibrosis across solid organs

D. Griggs, C. Betsholtz, J. Iredale, 2013, Nature Network Boston.

Collagen measured in primary cultures of normal rat hepatocytes derives from lipocytes within the monolayer.

S. Friedman, J. Maher, D. Bissell, 1988, The Journal of clinical investigation.

A liver HIF-2α/IRS2 pathway sensitizes hepatic insulin signaling and is modulated by VEGF inhibition

C. Taniguchi, Kevin Wei, A. Giaccia, 2013, Nature Medicine.

Corrigendum: VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis

Kevin Wei, S. Schrier, Betty Y. Y. Tam, 2009, Nature Medicine.

ANIT toxicity toward mouse hepatocytes in vivo is mediated primarily by neutrophils via CD18.

J. Maher, Ping Wu, E. Brown, 2006, American journal of physiology. Gastrointestinal and liver physiology.

Loss of Integrin αvβ8 in Murine Hepatocytes Accelerates Liver Regeneration

Richard S. Taylor, J. Iredale, D. Sheppard, 2019, The American journal of pathology.

The extracellular matrix in liver regeneration

J. Maher, 1998 .

Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α

J. Maher, T. Iwawaki, K. Kohno, 2020, Cell Death & Differentiation.

Fat‐storing cells and myofibroblasts: One cell or two?

J. Maher, 1989, Hepatology.

Isocaloric manipulation of macronutrients within a high-carbohydrate/moderate-fat diet induces unique effects on hepatic lipogenesis, steatosis and liver injury.

J. Maher, S. Turner, M. Hellerstein, 2016, The Journal of nutritional biochemistry.

Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1 s⃞ Published, JLR Papers in Press, July 8, 2006.

R. E. Pitas, J. Maher, T. Badger, 2006, Journal of Lipid Research.

iPSC-derived hepatocytes from patients with nonalcoholic fatty liver disease display a disease-specific gene expression profile.

J. Maher, H. Willenbring, Dounia Le Guillou, 2021, Gastroenterology.

Cell-specific expression of hepatocyte growth factor in liver. Upregulation in sinusoidal endothelial cells after carbon tetrachloride.

J. Maher, J J Maher, 1993, The Journal of clinical investigation.

Alcoholic steatosis and steatohepatitis.

J. Maher, 2002, Seminars in gastrointestinal disease.

Specific Macronutrients Exert Unique Influences on the Adipose-Liver Axis to Promote Hepatic Steatosis in Mice

J. Maher, S. Turner, Soo-Jin Cho, 2017, Cellular and molecular gastroenterology and hepatology.

CD18 deficiency improves liver injury in the MCD model of steatohepatitis

J. Maher, Andrew A. Pierce, J. Baron, 2017, PloS one.

Pathogenesis of NAFLD and NASH

J. Maher, 2016 .

Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation

Bruce Wang, M. Mack, J. Maher, 2020, Scientific Reports.

Dietary sucrose is essential to the development of liver injury in the methionine-choline-deficient model of steatohepatitis[S]

Scott M Turner, H. Ogata, J. Maher, 2009, Journal of Lipid Research.

New insights from rodent models of fatty liver disease.

J. Maher, 2011, Antioxidants & redox signaling.

Mechanisms of Liver Injury in Non-Alcoholic Steatohepatitis

J. Maher, Caroline C. Duwaerts, 2014, Current Hepatology Reports.

Interactions between Hepatic Stellate Cells and the Immune System

J. Maher, 2001, Seminars in liver disease.

Assessment of factors associated with pre‐diabetes in HCV infection including direct and dynamic measurements of insulin action

J. Maher, M. Khalili, C. Ayala, 2012, Journal of viral hepatitis.

Hepatic fibrosis: evaluation with semiquantitative contrast-enhanced CT.

Benjamin M Yeh, S. Kakar, B. Yeh, 2013, Radiology.

Alcoholic steatohepatitis: Management and prognosis

J. Maher, 2007, Current gastroenterology reports.

iPSC-derived hepatocytes from patients with nonalcoholic fatty liver disease display a disease-specific gene expression profile

J. Maher, H. Willenbring, Aras N. Mattis, 2020, bioRxiv.

Modeling and therapeutic targeting of inflammation-induced hepatic insulin resistance using human iPSC-derived hepatocytes and macrophages

E. Hsiao, J. Maher, H. Willenbring, 2023, Nature communications.

Table of contents

P. Easterbrook, J. Pawlotsky, J. Maher, 2016 .

CHEMOKINES AND ALCOHOLIC LIVER DISEASE

J. Maher, 1998 .

Rat hepatocytes and Kupffer cells interact to produce interleukin-8 (CINC) in the setting of ethanol.

J. Maher, 1995, The American journal of physiology.

Cytokines: Overview

J. Maher, 1999, Seminars in liver disease.

Insulin Sensitivity and Variability in Hepatitis C Virus Infection Using Direct Measurement

P. Bacchetti, J. Maher, M. Khalili, 2013, Digestive Diseases and Sciences.

Induced Pluripotent Stem Cell–derived Hepatocytes From Patients With Nonalcoholic Fatty Liver Disease Display a Disease-specific Gene Expression Profile

J. Maher, H. Willenbring, Dounia Le Guillou, 2021, Gastroenterology.

Antidiabetic treatment for NASH?

J. Maher, 2001, Hepatology.

Stress signaling in the methionine-choline-deficient model of murine fatty liver disease.

J. Maher, J. Grenert, R. K. Soon, 2010, Gastroenterology.

Selective αv integrin depletion identifies a core, targetable molecular pathway that regulates fibrosis across solid organs

D. Griggs, C. Betsholtz, J. Iredale, 2013, Nature Medicine.

Computational experiments reveal plausible mechanisms for changing patterns of hepatic zonation of xenobiotic clearance and hepatotoxicity.

S. Sheikh-Bahaei, J. Maher, C. Anthony Hunt, 2010, Journal of Theoretical Biology.

Activation of the Met Receptor by Cell Attachment Induces and Sustains Hepatocellular Carcinomas in Transgenic Mice

L. Ferrell, J. Bishop, J. Maher, 2001, The Journal of cell biology.

Lipids in liver disease: looking beyond steatosis.

R. Schwabe, J. Maher, 2012, Gastroenterology.

Dietary fructose exacerbates hepatocellular injury when incorporated into a methionine‐choline‐deficient diet

J. Maher, J. Grenert, R. K. Soon, 2010, Liver international : official journal of the International Association for the Study of the Liver.

Modeling fatty liver disease in animals: Is there an optimal approach, and is the effort worthwhile?

J. Maher, Jacquelyn J. Maher, 2016, Hepatology.

Edinburgh Research Explorer Loss of integrin v8 in murine hepatocytes accelerates liver regeneration

J. Maher, A. Atakilit, Koy Saeteurn, 2019 .

Doxycycline Significantly Enhances Induction of Induced Pluripotent Stem Cells to Endoderm by Enhancing Survival Through Protein Kinase B Phosphorylation

Julie B. Sneddon, M. Medina, J. Maher, 2021, Hepatology.