D. Lahiri

发表

Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD

Demao Chen, N. Zawia, Jinfang Wu, 2008, The Journal of Neuroscience.

Functional microRNAs in Alzheimer’s disease and cancer: differential regulation of common mechanisms and pathways

Andrew J. Saykin, Tatiana Foroud, A. Saykin, 2013, Front. Gene..

Epigenetics, oxidative stress, and Alzheimer disease.

N. Zawia, F. Cardozo-Pelaez, D. Lahiri, 2009, Free radical biology & medicine.

Melatonin, nitric oxide and alzheimer's disease - a minireview.

J. Salonen, D. Lahiri, J. Kumpulainen, 1999 .

Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease.

A. Thomson, Xudong Huang, A. Bush, 2008, Biochemical Society transactions.

N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, vascular dementia and Parkinson's disease.

N. Greig, Xudong Huang, D. Lahiri, 2012, Current Alzheimer research.

Functional characterization of three single‐nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA–protein interactions

Debomoy K Lahiri, Ronald C Petersen, John Hardy, 2009, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

An Iron-responsive Element Type II in the 5′-Untranslated Region of the Alzheimer's Amyloid Precursor Protein Transcript*

Xudong Huang, Debomoy K Lahiri, Rudolph E Tanzi, 2002, The Journal of Biological Chemistry.

Metal and inflammatory targets for Alzheimer's disease.

D. Lahiri, J. Rogers, 2004, Current drug targets.

Lifespan profiles of Alzheimer ' s disease – associated genes and their products in monkeys and mice

G. J. Harry, R. Basha, N. Zawia, 2016 .

Late-onset Alzheimer's disease, heating up and foxed by several proteins: pathomolecular effects of the aging process.

Kavita Shah, Kwangsik Nho, Debomoy K Lahiri, 2014, Journal of Alzheimer's disease : JAD.

Transforming Growth Factor-β1 Potentiates Amyloid-β Generation in Astrocytes and in Transgenic Mice*

E. Mackenzie, A. Delacourte, L. Buée, 2003, The Journal of Biological Chemistry.

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer’s disease and multiple sclerosis

M. Srinivasan, D. Lahiri, 2015, Expert opinion on therapeutic targets.

Functional activity of the novel Alzheimer's amyloid β-peptide interacting domain (AβID) in the APP and BACE1 promoter sequences and implications in activating apoptotic genes and in amyloidogenesis.

Bryan Maloney, D. Lahiri, Y. Ge, 2011, Gene.

Dietary supplementation with melatonin reduces levels of amyloid beta‐peptides in the murine cerebral cortex

Debomoy K Lahiri, Stephen C Bondy, Demao Chen, 2004, Journal of pineal research.

Role of nitric oxide in neurodegeneration and vulnerability of neuronal cells to nitric oxide metabolites and reactive oxygen species

N. Greig, D. Lahiri, S. Bondy, 2010 .

Memantine lowers amyloid‐β peptide levels in neuronal cultures and in APP/PS1 transgenic mice

H. Tanila, B. Ray, Demao Chen, 2010, Journal of neuroscience research.

Differential effects of two hexahydropyrroloindole carbamate-based anticholinesterase drugs on the amyloid beta protein pathway involved in alzheimer disease

N. Greig, Demao Chen, D. Lahiri, 2007, NeuroMolecular Medicine.

Neuronal Differentiation Is Accompanied by Increased Levels of SNAP‐25 Protein in Fetal Rat Primary Cortical Neurons

D. Lahiri, J. Bailey, 2006, Annals of the New York Academy of Sciences.

High Levels of Alzheimer Beta-Amyloid Precursor Protein (APP) in Children With Severely Autistic Behavior and Aggression

M. Farlow, Demao Chen, Bryan Maloney, 2006, Journal of child neurology.

Aluminum and copper in drinking water enhance inflammatory or oxidative events specifically in the brain

Demao Chen, D. Lahiri, S. Bondy, 2006, Journal of Neuroimmunology.

Factors that influence radioimmunoassay of human plasma melatonin: a modified column procedure to eliminate interference.

J. Nurnberger, D. Lahiri, D. Davis, 1993, Biochemical Medicine and Metabolic Biology.

The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells.

M. Farlow, D. Lahiri, K. Sambamurti, 1998, Brain research. Molecular brain research.

Melatonin affects the metabolism of the β‐amyloid precursor protein in different cell types

D. Lahiri, 1999, Journal of pineal research.

Interactions between Melatonin, Reactive Oxygen Species, and Nitric Oxide

D. Lahiri, C. Ghosh, D. K. Lahiri, 1999, Annals of the New York Academy of Sciences.

Effect of a Memory‐Enhancing Drug, AIT‐082, on the Level of Synaptophysin

M. Farlow, D. Lahiri, Y. Ge, 2000, Annals of the New York Academy of Sciences.

Dietary modulation of age-related changes in cerebral pro-oxidant status

T. J. Walsh, T. Walsh, D. Lahiri, 2002, Neurochemistry International.

A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease.

L. Schneider, N. Greig, E. Giacobini, 2003, Current drug targets.

D. Lahiri, S. Bondy, Y. Ge, 2004, Journal of pineal research.

Gene structure and organization of the human beta-secretase (BACE) promoter.

Bryan Maloney, D. Lahiri, Y. Ge, 2004, The FASEB Journal.

Characterization of the human beta-secretase 2 (BACE2) 5'-flanking region: identification of a 268-bp region as the basal BACE2 promoter.

N. Greig, Bryan Maloney, D. Lahiri, 2006, Journal of molecular neuroscience : MN.

Nicotine lowers the secretion of the Alzheimer's amyloid β-protein precursor that contains amyloid β-peptide in rat

N. Greig, V. Haroutunian, D. Ingram, 2002 .

Nicotine lowers the secretion of the Alzheimer's amyloid beta-protein precursor that contains amyloid beta-peptide in rat.

N. Greig, V. Haroutunian, D. Ingram, 2002, Journal of Alzheimer's disease : JAD.

Variants in Ion Channel Genes Link Phenotypic Features of Bipolar Illness to Specific Neurobiological Process Domains

J. Nurnberger, D. Lahiri, Y. Balaraman, 2015, Molecular Neuropsychiatry.

Copper Depletion Down-regulates Expression of the Alzheimer's Disease Amyloid-β Precursor Protein Gene*

G. Multhaup, S. Bellingham, Bryan Maloney, 2004, Journal of Biological Chemistry.

Characterization of the 5'-end region and the first two exons of the beta-protein precursor gene.

N. Robakis, D. Lahiri, S. Salton, 1989, Biochemical and biophysical research communications.

The promoter activity of the gene encoding Alzheimer beta-amyloid precursor protein (APP) is regulated by two blocks of upstream sequences.

N. Robakis, D. Lahiri, 1991, Brain research. Molecular brain research.

An region upstream of the gene promoter for the beta-amyloid precursor protein interacts with proteins from nuclear extracts of the human brain and PC12 cells.

D. Lahiri, 1998, Brain research. Molecular brain research.

High‐Affinity Choline Uptake (HACU) and Choline Acetyltransferase (ChAT) Activity in Neuronal Cultures for Mechanistic and Drug Discovery Studies

B. Ray, D. Lahiri, J. Simon, 2012, Current protocols in neuroscience.

Determination of high-affinity choline uptake (HACU) and choline acetyltransferase (ChAT) activity in the same population of cultured cells

B. Ray, D. Lahiri, J. Simon, 2009, Brain Research.

accumulation via translational repression of Amyloid Precursor Protein (APP) and H-Ferritin

Allegra T. Aron, Xudong Huang, A. Bush, 2018 .

Manganese causes neurotoxic iron accumulation via translational repression of amyloid precursor protein and H‐Ferritin

Allegra T. Aron, Xudong Huang, A. Bush, 2018, Journal of neurochemistry.

Transgenerational latent early-life associated regulation unites environment and genetics across generations.

J. Nurnberger, N. Greig, Bryan Maloney, 2016, Epigenomics.

APH1, PEN2, and Nicastrin increase Aβ levels and γ-secretase activity

J. Hardy, D. Lahiri, L. Marlow, 2003 .

The "aged garlic extract:" (AGE) and one of its active ingredients S-allyl-L-cysteine (SAC) as potential preventive and therapeutic agents for Alzheimer's disease (AD).

B. Ray, D. Lahiri, N. Chauhan, 2011, Current medicinal chemistry.

Novel Nuclear Factor-KappaB Targeting Peptide Suppresses β-Amyloid Induced Inflammatory and Apoptotic Responses in Neuronal Cells

M. Srinivasan, D. Lahiri, Baindu L. Bayon, 2016, PloS one.

Glucagon‐like peptide‐1 decreases endogenous amyloid‐β peptide (Aβ) levels and protects hippocampal neurons from death induced by Aβ and iron

M. Mattson, N. Greig, Demao Chen, 2003 .

An analog of thyrotropin-releasing hormone (TRH) is neuroprotective against glutamate-induced toxicity in fetal rat hippocampal neurons in vitro

James O. Jackson, Michael C Veronesi, M. Kubek, 2007, Brain Research.

Impact of acamprosate on behavior and brain-derived neurotrophic factor: an open-label study in youth with fragile X syndrome

C. McDougle, B. Ray, D. Lahiri, 2013, Psychopharmacology.

A cardinal sin when researching neuropsin/KLK8: Thou shalt validate antibodies

M. Thakur, Bryan Maloney, D. Lahiri, 2017, Alzheimer's & Dementia.

Translation of Pre-Clinical Studies into Successful Clinical Trials for Alzheimer's Disease: What are the Roadblocks and How Can They Be Overcome?

C. Masters, Ying Ding, Wei Chen, 2015, Journal of Alzheimer's disease : JAD.

Cholesterol and APOE genotype interact to influence Alzheimer disease progression

J. Poirier, D. Lahiri, R. Evans, 2004, Neurology.

The Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: characterizing a new regulatory motif.

Bryan Maloney, D. Lahiri, 2011, Gene.

BACE1 gene promoter is differentially regulated

Bryan Maloney, D. Lahiri, Y. Ge, 2007, Journal of Molecular Neuroscience.

Rivastigmine Lowers Aβ and Increases sAPPα Levels, Which Parallel Elevated Synaptic Markers and Metabolic Activity in Degenerating Primary Rat Neurons

N. Greig, B. Ray, D. Lahiri, 2011, PloS one.

Increased vulnerability of neuronal cell lines to sodium nitroprusside-mediated toxicity is caused by the decreased level of nitric oxide metabolites

D. Lahiri, C. Ghosh, 2007, Journal of Molecular Neuroscience.

Exposure to lead (Pb) and the developmental origin of oxidative DNA damage in the aging brain

R. Basha, N. Zawia, David P Cox, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Multidimensional insights into the repeated electromagnetic field stimulation and biosystems interaction in aging and age-related diseases

D. Lahiri, F. Perez, J. P. Bandeira, 2022, Journal of biomedical science.

Tacrine Reduces the Secretion of Soluble Amyloid Beta-Peptides in a Neuroblastoma Cell Line

M. Farlow, D. Lahiri, 1998 .

High-resolution detection of PCR products from a microsatellite marker using a nonradioisotopic technique.

J. Nurnberger, D. Lahiri, A. Zhang, 1997, Biochemical and molecular medicine.

Chronic exposure to aluminum in drinking water increases inflammatory parameters selectively in the brain

D. Lahiri, S. Bondy, A. Campbell, 2004, Journal of neuroscience research.

Developmental Expression of the β‐Amyloid Precursor Protein and Heat‐Shock Protein 70 in the Cerebral Hemisphere Region of the Rat Brain

J. Nurnberger, D. Lahiri, J. Nurnberger, 2002, Annals of the New York Academy of Sciences.

A polymeric nanoparticle formulation of curcumin (NanoCurc™) ameliorates CCl4-induced hepatic injury and fibrosis through reduction of pro-inflammatory cytokines and stellate cell activation

Toby C. Cornish, A. Maitra, A. Maitra, 2011, Laboratory Investigation.

Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron.

M. Mattson, N. Greig, Demao Chen, 2003, Journal of neuroscience research.

Lithium alters expression of RNAs in a type-specific manner in differentiated human neuroblastoma neuronal cultures, including specific genes involved in Alzheimer’s disease

J. Nurnberger, J. Kelsoe, H. Edenberg, 2019, Scientific Reports.

MicroRNA-153 Physiologically Inhibits Expression of Amyloid-β Precursor Protein in Cultured Human Fetal Brain Cells and Is Dysregulated in a Subset of Alzheimer Disease Patients*

B. Ray, D. Lahiri, J. Long, 2012, The Journal of Biological Chemistry.

Exendin-4 Ameliorates Motor Neuron Degeneration in Cellular and Animal Models of Amyotrophic Lateral Sclerosis

M. Mattson, N. Greig, H. Holloway, 2012, PloS one.

A serine protease KLK8 emerges as a regulator of regulators in memory: Microtubule protein dependent neuronal morphology and PKA-CREB signaling

M. Thakur, Bryan Maloney, D. Lahiri, 2018, Scientific Reports.

There is no Failure, Only Discovery-the Year Ahead for CARving New Paths.

D. Lahiri, 2020, Current Alzheimer research.

Overview of immunotherapy in Alzheimer's disease (AD) and mechanisms of IVIG neuroprotection in preclinical models of AD.

D. Lahiri, S. Counts, 2014, Current Alzheimer research.

Nuclear factor-kappa B: Glucocorticoid-induced leucine zipper interface analogs suppress pathology in an Alzheimer's disease model

M. Srinivasan, D. Lahiri, D. Hickman, 2018, Alzheimer's & dementia.

A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells.

N. Greig, Demao Chen, Jie Zhou, 2002, The Journal of pharmacology and experimental therapeutics.

GLP-1 Receptor Stimulation Reduces Amyloid- β Peptide Accumulation and Cytotoxicity in Cellular and Animal Models of Alzheimer’s Disease

M. Mattson, B. Ray, Yazhou Li, 2010 .

Nicotine reduces the secretion of Alzheimer's beta-amyloid precursor protein containing beta-amyloid peptide in the rat without altering synaptic proteins.

N. Greig, D. Ingram, M. Farlow, 2002, Annals of the New York Academy of Sciences.

Autism, Alzheimer disease, and fragile X

B. Ray, Bryan Maloney, D. Lahiri, 2011, Neurology.

Amyloid, Cholinesterase, Melatonin, and Metals and Their Roles in Aging and Neurodegenerative Diseases

N. Greig, Demao Chen, D. Lahiri, 2005, Annals of the New York Academy of Sciences.

Advances in Alzheimer therapy: development of innovative new strategies.

N. Greig, E. Giacobini, D. Lahiri, 2007, Current Alzheimer research.

Editorial [Hot Topic: Advances in Alzheimer Therapy: Development of Innovative New Strategies (Guest Editors: Nigel H. Greig, Ezio Giacobini and Debomoy K. Lahiri)]

N. Greig, E. Giacobini, D. Lahiri, 2007 .

Neuroprotective and neurorescue effects of a novel polymeric nanoparticle formulation of curcumin (NanoCurc™) in the neuronal cell culture and animal model: implications for Alzheimer's disease.

A. Maitra, A. Maitra, B. Ray, 2011, Journal of Alzheimer's disease : JAD.

Melatonin, Nitric Oxide Synthase and Oxidative Stress: Implications in Aging

J. Nurnberger, D. Lahiri, S. Bondy, 2002 .

Does Nitric Oxide Synthase Contribute to the Pathogenesis of Alzheimer's Disease?

N. Greig, D. Ingram, M. Farlow, 2003, Annals of the New York Academy of Sciences.

Glucocorticoid Induced Leucine Zipper in Lipopolysaccharide Induced Neuroinflammation

M. Srinivasan, D. Lahiri, D. Hickman, 2019, Front. Aging Neurosci..

Addendum “APH1, PEN2, and Nicastrin increase Aβ levels and γ-secretase activity” [Biochem. Biophys. Res. Commun. 305 (2003) 502–509]

J. Hardy, D. Lahiri, L. Marlow, 2003 .

Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents.

N. Greig, D. Lahiri, J. Rogers, 2004, Current pharmaceutical design.

Genes are not our destiny: the somatic epitype bridges between the genotype and the phenotype

Bryan Maloney, D. Lahiri, 2006, Nature Reviews Neuroscience.

Translation and processing of amyloid precursor protein (APP) by an M1 muscarinic agonist and an acetylcholinesterase inhibitor: the role of APP mRNA5'-untranslated region sequences

N. Greig, D. Lahiri, A. Fisher, 2005 .

Functional characterization of a competitive peptide antagonist of p65 in human macrophage-like cells suggests therapeutic potential for chronic inflammation

M. Srinivasan, D. Lahiri, Corinne Blackburn, 2014, Drug design, development and therapy.

Human microRNA (miR-20b-5p) modulates Alzheimer’s disease pathways and neuronal function, and a specific polymorphism close to the MIR20B gene influences Alzheimer’s biomarkers

K. Nho, P. Nelson, Bryan Maloney, 2022, Molecular Psychiatry.

Synaptosome microRNAs regulate synapse functions in Alzheimer’s disease

R. Swerdlow, P. Reddy, D. Lahiri, 2021, bioRxiv.

Co-localization and distribution of cerebral APP and SP1 and its relationship to amyloidogenesis.

G. J. Harry, R. Basha, N. Zawia, 2008, Journal of Alzheimer's disease : JAD.

Differential effect of tacrine and physostigmine on the secretion of the β-amyloid precursor protein in cell lines

M. Farlow, D. Lahiri, 2007, Journal of Molecular Neuroscience.

Regulation of Promoter Activity of the APP Gene by Cytokines and Growth Factors

D. Lahiri, Y. Ge, D. K. Lahiri, 2002, Annals of the New York Academy of Sciences.

NF-κB mediates amyloid β peptide-stimulated activity of the human apolipoprotein E gene promoter in human astroglial cells

S. Paul, M. Farlow, Bryan Maloney, 2005 .

NF-(kappa)B mediates amyloid beta peptide-stimulated activity of the human apolipoprotein E gene promoter in human astroglial cells.

S. Paul, M. Farlow, Bryan Maloney, 2005, Brain research. Molecular brain research.

Functional Characterization of Amyloid β Precursor Protein Regulatory Elements: Rationale for the Identification of Genetic Polymorphism

D. Lahiri, 2004, Annals of the New York Academy of Sciences.

Cholesterol and Alzheimer's disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors.

N. Greig, A. Granholm, J. Mintzer, 2004, Current drug targets.

Efficient DNA transfection in neuronal and astrocytic cell lines

D. Lahiri, Weihong Song, C. Ghosh, 2000, Molecular Biology Reports.

Human primary mixed brain cultures: preparation, differentiation, characterization and application to neuroscience research

B. Ray, D. Lahiri, N. Chopra, 2014, Molecular Brain.

Biochemical evidence for the dysregulation of Alzheimer’s Amyloid Precursor Protein (APP) expression and metabolism in Fragile X Syndrome (FXS) and severe autism

B. Ray, D. Lahiri, J. Long, 2011 .

Neuropathological and immunochemical studies of brain parenchyma in acetylcholinesterase knockout mice: implications in Alzheimer's disease.

E. Duysen, D. Lahiri, O. Lockridge, 2007, Journal of Alzheimer's disease : JAD.

APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity.

J. Hardy, D. Lahiri, L. Marlow, 2003, Biochemical and biophysical research communications.

Thiothalidomides: novel isosteric analogues of thalidomide with enhanced TNF-alpha inhibitory activity.

N. Greig, Qian-sheng Yu, XiaoXiang Zhu, 2003, Journal of medicinal chemistry.

A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies.

J. Nurnberger, D. Lahiri, John I. Nurnberger, 1991, Nucleic acids research.

DNA isolation by a rapid method from human blood samples: Effects of MgCl2, EDTA, storage time, and temperature on DNA yield and quality

D. Lahiri, Bill Schnabel, 1993, Biochemical Genetics.

DNA isolation by a rapid method from human blood samples: Effects of MgCl2, EDTA, storage time, and temperature on DNA yield and quality

D. Lahiri, Bill Schnabel, 2004, Biochemical Genetics.

Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine.

N. Greig, J. Deschamps, Qian-sheng Yu, 2005, Journal of medicinal chemistry.

Glucocorticoid-Induced Leucine Zipper in Central Nervous System Health and Disease

M. Srinivasan, D. Lahiri, 2017, Molecular Neurobiology.

Title : Glucocorticoid induced leucine zipper in central nervous system health and disease

M. Srinivasan, D. Lahiri, 2016 .

Butyrylcholinesterase: a new therapeutic target in AD treatment?

N. Greig, D. Ingram, Qian-sheng Yu, 2001 .

A Single Copy of Carbonic anhydrase 2 Restores Wild-type Circadian Period to Carbonic Anhydrase II-Deficient Mice

D. Lahiri, J. Trofatter, J. Hofstetter, 2006, Behavior genetics.

Memantine treatment decreases levels of secreted Alzheimer's amyloid precursor protein (APP) and amyloid beta (Aβ) peptide in the human neuroblastoma cells

N. Greig, B. Ray, D. Lahiri, 2010, Neuroscience Letters.

Effects of cholinesterase inhibitors on the secretion of beta-amyloid precursor protein in cell cultures.

J. Nurnberger, N. Greig, M. Farlow, 1997, Annals of the New York Academy of Sciences.

Efficacy and toxicity of clioquinol treatment and A-beta42 inoculation in the APP/PSI mouse model of Alzheimer's disease.

D. Holtzman, L. Schmued, B. Ray, 2013, Current Alzheimer research.

Analysis of peripheral amyloid precursor protein in Angelman Syndrome

B. Ray, D. Lahiri, C. Erickson, 2016, American journal of medical genetics. Part A.

An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease.

N. Greig, Qian-sheng Yu, A. Brossi, 2005, Current Alzheimer research.

Restraint stress and repeated CRF receptor activation in the amygdala both increase amyloid β precursor protein (APP) and amyloid- β (A β ) peptide but have divergent effects on BDNF and pre-synaptic proteins in the prefrontal cortex of rats

B. Ray, A. Shekhar, D. Lahiri, 2012 .

Cholinesterase inhibitors, β‐amyloid precursor protein and amyloid β‐peptides in Alzheimer's disease

N. Greig, M. Farlow, D. Lahiri, 2000 .

Impact of acamprosate on behavior and brain-derived neurotrophic factor: an open-label study in youth with fragile X syndrome

C. McDougle, B. Ray, D. Lahiri, 2013, Psychopharmacology.

Vaccinia Virus Complement Control Protein Reduces Inflammation and Improves Spinal Cord Integrity Following Spinal Cord Injury

D. Lahiri, Scott A. Smith, G. Kotwal, 2004, Annals of the New York Academy of Sciences.

Immunoprecipitation of 70S, 50S and 30S ribosomes ofEscherichia coli

D. P. Burma, D. Lahiri, 1980, Journal of Biosciences.

Current drug targets for modulating Alzheimer's amyloid precursor protein: role of specific micro-RNA species.

D. Lahiri, J. Long, 2011, Current medicinal chemistry.

Temperamental fearfulness in childhood and the serotonin transporter promoter region polymorphism: a multimethod association study

J. Nurnberger, D. Klein, Bryan Maloney, 2007, Psychiatric genetics.

Design, synthesis and biological assessment of novel N-substituted 3-(phthalimidin-2-yl)-2,6-dioxopiperidines and 3-substituted 2,6-dioxopiperidines for TNF-α inhibitory activity.

N. Greig, Qian-sheng Yu, H. Holloway, 2011, Bioorganic & medicinal chemistry.

Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent

N. Greig, D. Ingram, Qian-sheng Yu, 2005 .

Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.

N. Greig, Qian-sheng Yu, H. Holloway, 2006, Journal of medicinal chemistry.

Novel p53 inactivators with neuroprotective action: syntheses and pharmacological evaluation of 2-imino-2,3,4,5,6,7-hexahydrobenzothiazole and 2-imino-2,3,4,5,6,7-hexahydrobenzoxazole derivatives.

C. Culmsee, M. Mattson, N. Greig, 2002, Journal of medicinal chemistry.

Thalidomide-based TNF-inhibitors for neurodegenerative diseases

Rogers, N. Greig, Qian-sheng Yu, 2004 .

Thalidomide-based TNF-alpha inhibitors for neurodegenerative diseases.

N. Greig, Qian-sheng Yu, XiaoXiang Zhu, 2004, Acta neurobiologiae experimentalis.

Novel Anticholinesterases Based on the Molecular Skeletons of Furobenzofuran and Methanobenzodioxepine

N. Greig, J. Deschamps, Qian-sheng Yu, 2005 .

A New Therapeutic Target in Alzheimer's Disease Treatment: Attention to Butyrylcholinesterase

Xiaoxiang Zhu, Nigel H. Greig, Donald K. Ingram, 2001, Current medical research and opinion.

Butyrylcholinesterase: An Important New Target in Alzheimer's Disease Therapy

Debomoy K Lahiri, N. Greig, D. Lahiri, 2002, International Psychogeriatrics.

Role of early life exposure and environment on neurodegeneration: implications on brain disorders

D. Lahiri, A. Anand, Shweta Modgil, 2014, Translational Neurodegeneration.

Current drug targets for Alzheimer's disease treatment

N. Greig, M. Farlow, D. Lahiri, 2002 .

Promoter activity of the gene encoding the beta-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1.

D. Lahiri, C. Nall, Christina Nall, 1995, Brain research. Molecular brain research.

Nicotine Reduces the Secretion of Alzheimer's β‐Amyloid Precursor Protein Containing β‐Amyloid Peptide in the Rat without Altering Synaptic Proteins

N. Greig, D. Ingram, M. Farlow, 2002 .

Transcriptional Regulation of β-Secretase by p25/cdk5 Leads to Enhanced Amyloidogenic Processing

Bryan Maloney, D. Lahiri, Lili Wang, 2008, Neuron.

Gene structure and organization of the human β‐secretase (BACE) promoter

Bryan Maloney, D. Lahiri, Y. Ge, 2004 .

Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer’s disease

N. Greig, B. Ray, P. Nelson, 2020, Translational Psychiatry.

Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine.

N. Greig, Qian-sheng Yu, H. Holloway, 2010, Bioorganic & medicinal chemistry.

Transforming growth factor-beta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice.

E. Mackenzie, A. Delacourte, L. Buée, 2003, The Journal of biological chemistry.

PuF, an antimetastatic and developmental signaling protein, interacts with the Alzheimer’s amyloid-β precursor protein via a tissue-specific proximal regulatory element (PRE)

Bryan Maloney, D. Lahiri, J. Rogers, 2013, BMC Genomics.

Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer’s disease

Nigel H. Greig, N. Greig, D. Lahiri, 2002, NeuroMolecular Medicine.

New Therapeutic Strategies and Drug Candidates for Neurodegenerative Diseases: p53 and TNF‐α Inhibitors, and GLP‐1 Receptor Agonists

M. Mattson, N. Greig, T. Giordano, 2004 .

Role of cytokines in the gene expression of amyloid beta-protein precursor: identification of a 5'-UTR-binding nuclear factor and its implications in Alzheimer's disease.

N. Greig, D. Lahiri, D. Vivien, 2003, Journal of Alzheimer's disease : JAD.

Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease.

N. Greig, D. Lahiri, K. Bharani, 2015, Current Alzheimer research.

Targeting Tumor Necrosis Factor Alpha for Alzheimer's Disease.

Debomoy K Lahiri, M. Sabbagh, D. Lahiri, 2016, Current Alzheimer research.

Advances in microRNA experimental approaches to study physiological regulation of gene products implicated in CNS disorders

D. Lahiri, J. Long, 2012, Experimental Neurology.

Novel Roles of Amyloid-Beta Protein Precursor Metabolites in Fragile X Syndrome and Autism

Bryan Maloney, D. Lahiri, D. Sokol, 2016, Molecular Psychiatry.

Finding novel distinctions between the sAPPα-mediated anabolic biochemical pathways in Autism Spectrum Disorder and Fragile X Syndrome plasma and brain tissue

B. Ray, Bryan Maloney, D. Lahiri, 2016, Scientific Reports.

Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases.

Xudong Huang, D. Lahiri, C. Cahill, 2009, Biochimica et biophysica acta.

The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease.

M. Mattson, N. Greig, B. Ray, 2010, Journal of Alzheimer's disease : JAD.

Phenserine regulates translation of β-amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development

N. Greig, Qian-sheng Yu, A. Brossi, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Structural and functional characterization of H2 haplotype MAPT promoter: unique neurospecific domains and a hypoxia-inducible element would enhance rationally targeted tauopathy research for Alzheimer's disease.

Bryan Maloney, D. Lahiri, 2012, Gene.

Characterization of the human β-secretase 2 (BACE2) 5′-flanking region

N. Greig, Bryan Maloney, D. Lahiri, 2007, Journal of Molecular Neuroscience.

Functional domains of the BACE1 and BACE2 promoters and mechanisms of transcriptional suppression of the BACE2 promoter in normal neuronal cells

Bryan Maloney, D. Lahiri, Y. Ge, 2007, Journal of Molecular Neuroscience.

FMRP Regulates the Nuclear Export of Adam9 and Psen1 mRNAs: Secondary Analysis of an N6-Methyladenosine Dataset

Bryan Maloney, D. Lahiri, R. Alisch, 2020, Scientific Reports.

MicroRNA-339-5p Down-regulates Protein Expression of β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 (BACE1) in Human Primary Brain Cultures and Is Reduced in Brain Tissue Specimens of Alzheimer Disease Subjects*

B. Ray, D. Lahiri, J. Long, 2013, The Journal of Biological Chemistry.

Effects of microRNA-298 on APP and BACE1 translation differ according to cell type and 3′-UTR variation

D. Lahiri, Ruizhi Wang, 2022, Scientific Reports.

Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease.

S. Gauthier, J. Poirier, M. Farlow, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Biological Hallmarks of Cancer in Alzheimer’s Disease

A. Saykin, B. McDonald, K. Nudelman, 2019, Molecular Neurobiology.

Gene × environment interaction by a longitudinal epigenome-wide association study (LEWAS) overcomes limitations of genome-wide association study (GWAS).

Bryan Maloney, D. Lahiri, 2012, Epigenomics.

The "LEARn" (latent early-life associated regulation) model: an epigenetic pathway linking metabolic and cognitive disorders.

Bryan Maloney, D. Lahiri, 2012, Journal of Alzheimer's disease : JAD.

Proteolytic activation of proapoptotic kinase PKCdelta is regulated by overexpression of Bcl-2: implications for oxidative stress and environmental factors in Parkinson's disease.

D. Lahiri, M. Kitazawa, A. Kanthasamy, 2003, Annals of the New York Academy of Sciences.

Impact of acamprosate on plasma amyloid-β precursor protein in youth: a pilot analysis in fragile X syndrome-associated and idiopathic autism spectrum disorder suggests a pharmacodynamic protein marker.

C. McDougle, B. Ray, K. Bowers, 2014, Journal of psychiatric research.

The Fetal Basis of Amyloidogenesis: Exposure to Lead and Latent Overexpression of Amyloid Precursor Protein and β-Amyloid in the Aging Brain

R. Basha, N. Zawia, M. R. Basha, 2005, The Journal of Neuroscience.

Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5′-untranslated region: Implications in Alzheimer’s disease

Bryan Maloney, D. Lahiri, J. Rogers, 2018, Molecular Psychiatry.

Alcohol drinking and deprivation alter basal extracellular glutamate concentrations and clearance in the mesolimbic system of alcohol‐preferring (P) rats

W. Mcbride, D. Lahiri, E. Engleman, 2013, Addiction biology.

The Genetics of Autism

D. Lahiri, D. Sokol, 2011, International Handbook of Autism and Pervasive Developmental Disorders.

Initial analysis of peripheral lymphocytic extracellular signal related kinase activation in autism.

B. Ray, D. Lahiri, C. Erickson, 2017, Journal of psychiatric research.

Do epigenetic pathways initiate late onset Alzheimer disease (LOAD): towards a new paradigm.

N. Zawia, Bryan Maloney, D. Lahiri, 2012, Current Alzheimer research.

Targets for AD treatment: conflicting messages from γ‐secretase inhibitors

N. Greig, D. Lahiri, N. Bhat, 2011, Journal of neurochemistry.

A non-organic and non-enzymatic extraction method gives higher yields of genomic DNA from whole-blood samples than do nine other methods tested.

J. Nurnberger, D. Lahiri, M. Hodes, 1992, Journal of biochemical and biophysical methods.

Apolipoprotein gene and its interaction with the environmentally driven risk factors: molecular, genetic and epidemiological studies of Alzheimer’s disease

David A. Bennett, D. Bennett, D. Lahiri, 2004, Neurobiology of Aging.

The stability of β-amyloid precursor protein in nine different cell types

D. Lahiri, 1993 .

Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease

N. Greig, H. Holloway, B. Ray, 2012, Journal of Neuroinflammation.

Tumor necrosis factor-alpha synthesis inhibitor 3,6' -dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease

H. Praag, N. Greig, H. Holloway, 2012 .

MicroRNA-101 downregulates Alzheimer's amyloid-β precursor protein levels in human cell cultures and is differentially expressed.

Debomoy K Lahiri, D. Lahiri, J. Long, 2011, Biochemical and biophysical research communications.

A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by Cdk5

K. Shah, D. Lahiri, 2017, Molecular Neurobiology.

N. Greig, H. Holloway, B. Ray, 2012, Journal of Neuroinflammation.

Beyond the signaling effect role of amyloid-β42 on the processing of APP, and its clinical implications

Bryan Maloney, D. Lahiri, Debomoy K. Lahiri, 2010, Experimental Neurology.

Identification of Novel Small Molecule Inhibitors of Amyloid Precursor Protein Synthesis as a Route to Lower Alzheimer's Disease Amyloid-β Peptide

N. Greig, Qian-sheng Yu, H. Holloway, 2006, Journal of Pharmacology and Experimental Therapeutics.

Optimizing Drugs for Brain Action

N. Greig, D. Ingram, Qian-sheng Yu, 2001 .

Apolipoprotein E as a target for developing new therapeutics for Alzheimer’s disease based on studies from protein, RNA, and regulatory region of the gene

D. Lahiri, 2007, Journal of Molecular Neuroscience.

M1 muscarinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera

M. Thakur, R. Wadhwa, Bryan Maloney, 2019, Scientific Reports.

Genomic DNA from mice: a comparison of recovery methods and tissue sources.

J. Nurnberger, D. Lahiri, J. Hofstetter, 1997, Biochemical and molecular medicine.

Novel Contribution of Secreted Amyloid-β Precursor Protein to White Matter Brain Enlargement in Autism Spectrum Disorder

Bryan Maloney, D. Lahiri, D. Sokol, 2019, Front. Psychiatry.

Targeting APP metabolism for the treatment of Alzheimer's disease

J. Hardy, D. Lahiri, L. Refolo, 2002 .

Autism as early neurodevelopmental disorder: evidence for an sAPPα-mediated anabolic pathway

B. Ray, Bryan Maloney, D. Lahiri, 2013, Front. Cell. Neurosci..

The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases

N. Zawia, Bryan Maloney, D. Lahiri, 2009, Molecular Psychiatry.

Lifespan profiles of Alzheimer's disease-associated genes and products in monkeys and mice.

N. Zawia, Jinfang Wu, M. Basha, 2009, Journal of Alzheimer's disease : JAD.

How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the "LEARn" model (latent early-life associated regulation) may explain the triggering of AD.

N. Zawia, M. Basha, Bryan Maloney, 2007, Current Alzheimer research.

Mechanism of promoter activity of the β‐amyloid precursor protein gene in different cell lines: identification of a specific 30 bp fragment in the proximal promoter region

Bryan Maloney, D. Lahiri, Weihong Song, 2004, Journal of neurochemistry.

Presence of a “CAGA box” in the APP gene unique to amyloid plaque‐forming species and absent in all APLP‐1/2 genes: implications in Alzheimer's disease

N. Greig, Bryan Maloney, D. Lahiri, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Analysis of the 5'-flanking region of the beta-amyloid precursor protein gene that contributes to increased promoter activity in differentiated neuronal cells.

D. Lahiri, Y. Ge, W. Song1, 2000, Brain research. Molecular brain research.

Promoter activity of the beta-amyloid precursor protein gene is negatively modulated by an upstream regulatory element.

D. Lahiri, Y. Ge, C. Nall, 1999, Brain research. Molecular brain research.

Detection of the membrane-retained carboxy-terminal tail containing polypeptides of the amyloid precursor protein in tissue from Alzheimer's disease brain.

D. Lahiri, G. Kotwal, J. Daly, 1998, Life sciences.

Characterization of the APP proximal promoter and 5′‐untranslated regions: identification of cell‐type specific domains and implications in APP gene expression and Alzheimer's disease

Bryan Maloney, D. Lahiri, Y. Ge, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories

R. Nitsch, D. Lahiri, U. Konietzko, 2010, Neurobiology of Aging.

Role of the APP Promoter in Alzheimer's Disease: Cell Type‐Specific Expression of the β‐Amyloid Precursor Protein

D. Lahiri, Y. Ge, 2004, Annals of the New York Academy of Sciences.

Chromatographic separation of reaction products from the choline acetyltransferase and carnitine acetyltransferase assay: differential ChAT and CrAT activity in brain extracts from Alzheimer’s disease versus controls

D. Lahiri, J. Bailey, 2012, Journal of neurochemistry.

Increased Secreted Amyloid Precursor Protein-α (sAPPα) in Severe Autism: Proposal of a Specific, Anabolic Pathway and Putative Biomarker

B. Ray, D. Lahiri, J. Long, 2011, PloS one.

Restraint stress and repeated corticotrophin-releasing factor receptor activation in the amygdala both increase amyloid-β precursor protein and amyloid-β peptide but have divergent effects on brain-derived neurotrophic factor and pre-synaptic proteins in the prefrontal cortex of rats

B. Ray, A. Shekhar, D. Lahiri, 2011, Neuroscience.

Alzheimer’s disease drug discovery targeted to the APP mRNA 5′Untranslated region

N. Greig, S. Gullans, Xudong Huang, 2002, Journal of Molecular Neuroscience.

Characterization of two APP gene promoter polymorphisms that appear to influence risk of late-onset Alzheimer's disease

J. Hardy, F. W. Vrièze, Bryan Maloney, 2005, Neurobiology of Aging.

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism

M. Mattson, N. Greig, H. Holloway, 2009, Proceedings of the National Academy of Sciences.

Neuroprotection from Complement‐Mediated Inflammatory Damage

Debomoy K Lahiri, D. Lahiri, L. Kellaway, 2004, Annals of the New York Academy of Sciences.

Melatonin alters the metabolism of the β-amyloid precursor protein in the neuroendocrine cell line PC12

D. Lahiri, Weihong Song, 1997, Journal of Molecular Neuroscience.

Amyloid and Neurodegeneration: Alzheimer's Disease and Retinal Degeneration

N. Greig, D. Lahiri, C. Venugopal, 2009 .

Effect of ionophores on the processing of theβ-amyloid precursor protein in different cell lines

D. Lahiri, 1994, Cellular and Molecular Neurobiology.

Reversibility of the effect of tacrine on the secretion of the β-amyloid precursor protein in cultured cells

D. Lahiri, 1994, Neuroscience Letters.

Melatonin suppression by light in euthymic bipolar and unipolar patients.

Marvin J. Miller, J. Nurnberger, A. Lewy, 2000, Archives of general psychiatry.

Novel 5′ Untranslated Region Directed Blockers of Iron-Regulatory Protein-1 Dependent Amyloid Precursor Protein Translation: Implications for Down Syndrome and Alzheimer's Disease

Xudong Huang, S. Bandyopadhyay, D. Lahiri, 2013, PloS one.

Initial genome scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 4, 7, 9, 18, 19, 20, and 21q.

F. McMahon, J. Nurnberger, M. McInnis, 1997, American journal of medical genetics.

Apolipoprotein E genotypes and Alzheimer's disease in a community study of elderly African Americans

G. Schellenberg, O. Gureje, K. Hall, 1995, Annals of neurology.

Development and validation of the high-quality ‘rapid method for swab’ to genotype the HTTLPR serotonin transporter (SLC6A4) promoter polymorphism

J. Nurnberger, B. Ray, Bryan Maloney, 2009, Psychiatric genetics.

The secretion of amyloid β-peptides is inhibited in the tacrine-treated human neuroblastoma cells

M. Farlow, D. Lahiri, K. Sambamurti, 1998 .

Selective acetyl- and butyrylcholinesterase inhibitors reduce amyloid-β ex vivo activation of peripheral chemo-cytokines from Alzheimer's disease subjects: exploring the cholinergic anti-inflammatory pathway.

N. Greig, M. Kamal, Qian-sheng Yu, 2014, Current Alzheimer research.

Phenserine Regulates Translation of ß—Amyloid Precursor Protein Message

N. Greig, M. Farlow, D. Lahiri, 2002 .

Crossing the “Birth Border” for Epigenetic Effects

Bryan Maloney, D. Lahiri, D. Sokol, 2022, Biological Psychiatry.

Latent consequences of early-life lead (Pb) exposure and the future: Addressing the Pb crisis.

N. Zawia, Bryan Maloney, D. Lahiri, 2018, Neurotoxicology.

Epigenetics of dementia: understanding the disease as a transformation rather than a state

Bryan Maloney, D. Lahiri, 2016, The Lancet Neurology.

Applying epigenetics to Alzheimer's disease via the latent early-life associated regulation (LEARn) model.

N. Zawia, Bryan Maloney, D. Lahiri, 2012, Current Alzheimer research.

D. Lahiri, S. Bondy, Y. Ge, 2004, Journal of pineal research.

Regulation of the deleterious effects of binge-like exposure to alcohol during adolescence by α7 nicotinic acetylcholine receptor agents: prevention by pretreatment with a α7 negative allosteric modulator and emulation by a α7 agonist in alcohol-preferring (P) male and female rats

D. Lahiri, S. Hauser, R. Bell, 2020, Psychopharmacology.

Cdk5 activity in the brain – multiple paths of regulation

K. Shah, D. Lahiri, 2014, Journal of Cell Science.

Role of the APP non-amyloidogenic signaling pathway and targeting alpha-secretase as an alternative drug target for treatment of Alzheimer's disease.

S. Bandyopadhyay, D. Lahiri, L. Goldstein, 2007, Current medicinal chemistry.

Taking down the unindicted co-conspirators of amyloid beta-peptide-mediated neuronal death: shared gene regulation of BACE1 and APP genes interacting with CREB, Fe65 and YY1 transcription factors.

N. Greig, Bryan Maloney, D. Lahiri, 2006, Current Alzheimer research.

What can triumphs and tribulations from drug research in Alzheimer's disease tell us about the development of psychotropic drugs in general?

N. Greig, D. Lahiri, R. Becker, 2015, The lancet. Psychiatry.

Daidzein Augments Cholesterol Homeostasis via ApoE to Promote Functional Recovery in Chronic Stroke

D. Corbett, R. Ratan, D. Lahiri, 2015, The Journal of Neuroscience.

A novel effect of rivastigmine on pre‐synaptic proteins and neuronal viability in a neurodegeneration model of fetal rat primary cortical cultures and its implication in Alzheimer’s disease

D. Lahiri, J. Bailey, 2010, Journal of neurochemistry.

Neurine, an acetylcholine autolysis product, elevates secreted amyloid-beta protein precursor and amyloid-beta peptide levels, and lowers neuronal cell viability in culture: a role in Alzheimer's disease?

N. Greig, M. Kamal, Qian-sheng Yu, 2006, Journal of Alzheimer's disease : JAD.

GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease.

M. Mattson, N. Greig, H. Holloway, 2010, Journal of Alzheimer's disease : JAD.

Intravenous Immunoglobulin (IVIG) Treatment Exerts Antioxidant and Neuropreservatory Effects in Preclinical Models of Alzheimer’s Disease

B. Ray, E. Mufson, D. Lahiri, 2014, Journal of Clinical Immunology.

Lessons from a BACE1 inhibitor trial: Off-site but not off base

N. Greig, Bryan Maloney, D. Lahiri, 2014, Alzheimer's & Dementia.

Intravenous immunoglobulin treatment preserves and protects primary rat hippocampal neurons and primary human brain cultures against oxidative insults.

B. Ray, D. Lahiri, 2014, Current Alzheimer research.

Effect of IVIg in preserving human primary neurons and protecting them against oxidative stress

B. Ray, D. Lahiri, 2013, Alzheimer's & Dementia.

Oxidative insults to neurons and synapse are prevented by aged garlic extract and S‐allyl‐l‐cysteine treatment in the neuronal culture and APP‐Tg mouse model

B. Ray, D. Lahiri, N. Chauhan, 2011, Journal of neurochemistry.

The perils of Alzheimer's drug development.

L. Schneider, D. Lahiri, 2009, Current Alzheimer research.

Genomics of Brain Aging: Apolipoprotein E

Bryan Maloney, D. Lahiri, 2009 .

Apoptotic and behavioral sequelae of mild brain trauma in mice

N. Greig, H. Holloway, Yazhou Li, 2007, Journal of neuroscience research.

Treatment outcome of tacrine therapy depends on apolipoprotein genotype and gender of the subjects with Alzheimer's disease

J. Poirier, M. Farlow, D. Lahiri, 1998, Neurology.

The “LEARn” (Latent Early-life Associated Regulation) model integrates environmental risk factors and the developmental basis of Alzheimer’s disease, and proposes remedial steps

Bryan Maloney, D. Lahiri, 2010, Experimental Gerontology.

Novel drug targets based on metallobiology of Alzheimer's disease

Xudong Huang, S. Bandyopadhyay, D. Lahiri, 2010, Expert opinion on therapeutic targets.

genotype and gender of the subjects with Alzheimer ' s disease Treatment outcome of tacrine therapy depends on apolipoprotein

M. Farlow, D. Lahiri, S. Hui, 2007 .

Dissociation Between the Potent β-Amyloid Protein Pathway Inhibition and Cholinergic Actions of the Alzheimer Drug Candidates Phenserine and Cymserine

N. Greig, M. Kamal, Qian-sheng Yu, 2008 .

Potential for Stem Cells Therapy in Alzheimer's Disease: Do Neurotrophic Factors Play Critical Role?

Avijit Banik, Debomoy K Lahiri, Akshay Anand, 2017, Current Alzheimer research.

The Experimental Alzheimer's Disease Drug Posiphen [(+)-Phenserine] Lowers Amyloid-β Peptide Levels in Cell Culture and Mice

N. Greig, Qian-sheng Yu, H. Holloway, 2007, Journal of Pharmacology and Experimental Therapeutics.

What can triumphs and tribulations from Alzheimer’s disease drug research tell us about the development of psychotropic drugs in general?

N. Greig, D. Lahiri, R. Becker, 2016 .

Repeated electromagnetic field stimulation lowers amyloid-β peptide levels in primary human mixed brain tissue cultures

Bryan Maloney, D. Lahiri, N. Chopra, 2021, Scientific Reports.

Repeated electromagnetic field stimulation lowers amyloid-β peptide levels in primary human mixed brain tissue cultures

Bryan Maloney, D. Lahiri, N. Chopra, 2021, Scientific reports.

Phenserine: A Selective, Long-Acting and Brain-Directed Acetylcholinesterase Inhibitor Affecting Cognition and β-APP Processing

N. Greig, V. Haroutunian, D. Ingram, 1997 .

Effects of melatonin and age on gene expression in mouse CNS using microarray analysis

C. Cotman, V. Perreau, D. Lahiri, 2007, Neurochemistry International.

Melatonin Alters Age-Related Changes in Transcription Factors and Kinase Activation

D. Lahiri, Jun Zhou, S. Bondy, 2010, Neurochemical Research.

Negative and positive allosteric modulators of the α7 nicotinic acetylcholine receptor regulates the ability of adolescent binge alcohol exposure to enhance adult alcohol consumption

D. Lahiri, S. Hauser, R. Bell, 2023, Frontiers in Behavioral Neuroscience.

Advances in understanding Alzheimer's disease, and the contributions of current Alzheimer research: ten years on and beyond.

N. Greig, D. Lahiri, 2014, Current Alzheimer research.

Functional characterization of the 5′ flanking region of the BACE gene: identification of a 91 bp fragment involved in basal level of BACE promoter expression

Bryan Maloney, D. Lahiri, Y. Ge, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Potential Intervention by Vaccinia Virus Complement Control Protein of the Signals Contributing to the Progression of Central Nervous System Injury to Alzheimer's Disease

D. Lahiri, R. Hicks, G. Kotwal, 2002, Annals of the New York Academy of Sciences.

Incretin mimetics as pharmacological tools to elucidate and as a new drug strategy to treat traumatic brain injury

N. Greig, Yazhou Li, B. Hoffer, 2014 .

Incretin mimetics as pharmacologic tools to elucidate and as a new drug strategy to treat traumatic brain injury

N. Greig, Yazhou Li, D. Lahiri, 2014, Alzheimer's & Dementia.

Presence of precursor ribosome in the ribosomal preparation from chloramphenicol-treatedEscherichia coli AB301/I05 (RNase III-)

D. P. Burma, D. Lahiri, 1980, Journal of Biosciences.

(-)-Phenserine and Inhibiting Pre-Programmed Cell Death: In Pursuit of a Novel Intervention for Alzheimer's Disease.

L. Ferrucci, L. Schneider, N. Greig, 2018, Current Alzheimer research.

(−)-Phenserine and Inhibiting Apoptosis: In Pursuit of a Novel Intervention for Alzheimer’s Disease

Clive, Dimitrios, L. Ferrucci, 2018 .

Neuroinflammation in Alzheimer's disease: different molecular targets and potential therapeutic agents including curcumin.

B. Ray, D. Lahiri, 2009, Current opinion in pharmacology.

Lessons from Alzheimer's Disease (AD) Clinical Trials: Instead of "A-Drug", AD-D prevention to Avert AD.

D. Lahiri, 2019, Current Alzheimer research.

Effects of Reducing Norepinephrine Levels via DSP4 Treatment on Amyloid-β Pathology in Female Rhesus Macaques (Macaca Mulatta).

N. Greig, D. Ingram, B. Ray, 2019, Journal of Alzheimer's disease : JAD.

Racemic N1-norphenserine and its enantiomers: Unpredicted inhibition of human acetyl- and butyrylcholinesterase and β-amyloid precursor protein in vitro

N. Greig, Qian-sheng Yu, H. Holloway, 2003 .

Synthesis of the Alzheimer drug Posiphen into its primary metabolic products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their inhibition of amyloid precursor protein, α-Synuclein synthesis, interleukin-1β release, and cholinergic action.

N. Greig, M. Kamal, Qian-sheng Yu, 2013, Anti-inflammatory & anti-allergy agents in medicinal chemistry.

The alpha-synuclein 5′untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen

N. Greig, Xudong Huang, S. Bandyopadhyay, 2011, Journal of Neural Transmission.

Brain Aging: Influence of Early–Life Events on Late-Life Brain Disorders

D. Lahiri, 2012 .

The Vaccinia Virus N1L Protein Influences Cytokine Secretion in Vitro after Infection

J. Suttles, D. Lahiri, G. Kotwal, 2005, Annals of the New York Academy of Sciences.

Biochemical studies in Normal Pressure Hydrocephalus (NPH) patients: change in CSF levels of amyloid precursor protein (APP), amyloid-beta (Aβ) peptide and phospho-tau.

B. Ray, D. Lahiri, P. Reyes, 2011, Journal of psychiatric research.

Molecular and immunocytochemical characterization of primary neuronal cultures from adult rat brain: Differential expression of neuronal and glial protein markers

B. Ray, D. Lahiri, S. Sarkar, 2009, Journal of Neuroscience Methods.

The Integrated Role of Desferrioxamine and Phenserine Targeted to an Iron‐Responsive Element in the APP‐mRNA 5′‐Untranslated Region

N. Greig, A. Bush, T. Giordano, 2004, Annals of the New York Academy of Sciences.

A partial failure of membrane protein turnover may cause Alzheimer's disease: a new hypothesis.

N. Greig, D. Lahiri, C. Venugopal, 2006, Current Alzheimer research.

MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties

A. Saykin, K. Nho, Bryan Maloney, 2020, Molecular Psychiatry.

Electrophoretic mobility shift assay for the detection of specific DNA-protein complex in nuclear extracts from the cultured cells and frozen autopsy human brain tissue.

D. Lahiri, Y. Ge, 2000, Brain research. Brain research protocols.

Early-life events may trigger biochemical pathways for Alzheimer’s disease: the “LEARn” model

N. Greig, N. Zawia, Bryan Maloney, 2008, Biogerontology (Dordrecht).

Prions: a piece of the puzzle?

D. Lahiri, 2012, Science.

Lead ( Pb ) exposure and its effect on APP proteolysis and A β aggregation

H. Lashuel, M. Basha, D. Lahiri, 2005 .

The neurobehavioral and molecular phenotype of Angelman Syndrome

B. Ray, D. Lahiri, C. Erickson, 2013, American journal of medical genetics. Part A.

Melatonin-like immunoreactivity in the presence of different chemicals as determined by the radioimmunoassay.

J. Nurnberger, D. Lahiri, D. Davis, 1994, Biochemical medicine and metabolic biology.

Review: cholinesterase inhibitors have a modest effect on neuropsychiatric and functional outcomes in Alzheimer’s disease

M. Farlow, D. Lahiri, 2003, Evidence-based mental health.

New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists.

M. Mattson, N. Greig, T. Giordano, 2004, Annals of the New York Academy of Sciences.

Editorial: advances in Alzheimer therapy: something old, something new, something borrowed, something blue.

N. Greig, E. Giacobini, D. Lahiri, 2005, Current Alzheimer research.

Melatonin, Metals, and Gene Expression: Implications in Aging and Neurodegenerative Disorders

N. Greig, Demao Chen, D. Lahiri, 2004, Annals of the New York Academy of Sciences.

Editorial - Progress of Current Alzheimer Research

D. Lahiri, 2005 .

Lethal weapon: amyloid β-peptide, role in the oxidative stress and neurodegeneration of Alzheimer’s disease

N. Greig, D. Lahiri, 2004, Neurobiology of Aging.

Where the actions of environment (nutrition), gene and protein meet: beneficial role of fruit and vegetable juices in potentially delaying the onset of Alzheimer's disease.

D. Lahiri, 2006, Journal of Alzheimer's disease : JAD.

How autism and Alzheimer’s disease are TrAPPed

Bryan Maloney, D. Lahiri, J. Rogers, 2020, Molecular Psychiatry.

Apolipoprotein E Genotype and Gender Influence Response to Tacrine Therapy a

J. Poirier, D. Lahiri, S. Hui, 1996, Annals of the New York Academy of Sciences.

Methionine restriction leads to Aβ reduction and neuroprotection: Implications in Alzheimer's disease pathogenesis and prevention

N. Greig, D. Lahiri, K. Sambamurti, 2015, Alzheimer's & Dementia.

An integrated approach to genome studies.

D. Lahiri, 2011, Science.

Natural products and molecular therapy

D. Lahiri, G. Kotwal, 2005 .

Important differences between human and mouse APOE gene promoters: limitation of mouse APOE model in studying Alzheimer’s disease

Bryan Maloney, D. Lahiri, Y. Ge, 2007, Journal of neurochemistry.

P4-310 Effects of memantine on the activity of secretase enzymes in the human neuroblastoma cells

D. Lahiri, G. Alley, P. Banerjee, 2006, Alzheimer's & Dementia.

Early-emerging cognitive vulnerability to depression and the serotonin transporter promoter region polymorphism.

J. Nurnberger, D. Klein, Bryan Maloney, 2008, Journal of affective disorders.

The effect of tacrine and leupeptin on the secretion of the beta-amyloid precursor protein in HeLa cells.

M. Farlow, D. Lahiri, K. Sambamurti, 1997, Life Science.

Aging is Not a Disorder.

D. Lahiri, 2020, Current aging science.

Common Pathogenic Mechanisms between Down Syndrome and Alzheimer's Disease: Steps toward Therapy

A. Granholm, F. Schmitt, D. Colas, 2018 .

Significance of NF-κΒ as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer’s disease and multiple sclerosis

M. Srinivasan, D. Lahiri, 2015 .

A serine protease KLK8 emerges as a regulator of regulators in memory: Microtubule protein dependent neuronal morphology and PKA-CREB signaling

M. Thakur, Bryan Maloney, D. Lahiri, 2018, Scientific Reports.

N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, vascular dementia and Parkinson's disease.

N. Greig, Xudong Huang, D. Lahiri, 2012 .

Functional identification of the promoter of the gene encoding the Rhesus monkey beta-amyloid precursor protein.

D. Lahiri, W. Song, D. Lahiri, 1998, Gene.

Coming to grips with complex disorders: Genetic risk prediction in bipolar disorder using panels of genes identified through convergent functional genomics

Daniel L. Koller, F. McMahon, J. Nurnberger, 2010, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

The Mouse APLP2 Gene

A. Mammen, D. Gilbert, N. Jenkins, 1995, Journal of Biological Chemistry.

Editorial - Progress and Vision for ‘Current Aging Science’

D. Lahiri, Debomoy K. Lahiri, 2009 .

N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, vascular dementia and Parkinson's disease.

N. Greig, Xudong Huang, D. Lahiri, 2012 .

alters in a in including

J. Kelsoe, H. Edenberg, Bryan Maloney, 2019 .

Advances in Alzheimer therapy: understanding pharmacological approaches to the disease.

N. Greig, E. Giacobini, D. Lahiri, 2009, Current Alzheimer research.

Alzheimer’s disease – current trends in basic and clinical research. Highlights from the 16th ECNP

D. Lahiri, 2004, Expert opinion on investigational drugs.

Propranolol treatment during repetitive mild traumatic brain injuries induces transcriptomic changes in the bone marrow of mice

D. Lahiri, Tyler Nguyen, Alexander G. Obukhov, 2023, Frontiers in Neuroscience.

APPlications of amyloid-β precursor protein metabolites in macrocephaly and autism spectrum disorder

D. Lahiri, D. Sokol, 2023, Frontiers in molecular neuroscience.

Prions: a piece of the puzzle?

D. Lahiri, 2012, Science.

Tacrine alters the secretion of the beta‐amyloid precursor protein in cell lines

D. Lahiri, M. Farlow, D. Lahiri, 1994, Journal of neuroscience research.

Are pulmonary fibrosis and Alzheimer's disease linked? Shared dysregulation of two miRNA species and downstream pathways accompany both disorders

N. Greig, Bryan Maloney, D. Lahiri, 2017, Journal of Biological Chemistry.

Novel Specific MicroRNAs in Regulating Neuronal Genes Implicated In Alzheimer's Disease

D. Lahiri, J. Long, 2010, Alzheimer's & Dementia.

Sensitive Detection of Reporter Gene Assay Results

D. Lahiri, Y. Ge, J. Bailey, 2007 .

Isolation of the genomic clone of the rhesus monkey beta‐amyloid precursor protein

D. Lahiri, Weihong Songa, 1998, Biochemistry and molecular biology international.

Cholinesterase inhibitors, beta-amyloid precursor protein and amyloid beta-peptides in Alzheimer's disease.

N. Greig, M. Farlow, D. Lahiri, 2000, Acta neurologica Scandinavica. Supplementum.

Editorial [Progress of “Current Alzheimer Research” and Future Direction]

D. Lahiri, 2013 .

Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide.

N. Greig, Qian-sheng Yu, H. Holloway, 2006, The Journal of pharmacology and experimental therapeutics.

Neurodevelopmental disorders and microcephaly: how apoptosis, the cell cycle, tau and amyloid-β precursor protein APPly

D. Lahiri, D. Sokol, 2023, Frontiers in Molecular Neuroscience.

Lead (Pb) exposure and its effect on APP proteolysis and Aβ aggregation

M. Basha, D. Lahiri, Y. Ge, 2005 .

Amyloid‐β precursor protein synthesis inhibitors for Alzheimer's disease treatment

N. Greig, D. Lahiri, R. Becker, 2014, Annals of neurology.

How Biochemical Pathways for Disease May be Triggered by Early-Life Events

N. Zawia, Bryan Maloney, D. Lahiri, 2009 .

The “LEARn” (Latent Early-life Associated Regulation) model may explain the etiology of sporadic cases of Alzheimer's disease

B. Ray, N. Zawia, Bryan Maloney, 2009, Alzheimer's & Dementia.

C. McDougle, B. Ray, K. Bowers, 2014, Journal of Psychiatric Research.

Lessons from a BACE1 inhibitor trial: Off-site but not off base

N. Greig, Bryan Maloney, D. Lahiri, 2014, Alzheimer's & Dementia.

Memantine lowers amyloid‐β peptide levels in neuronal cultures and in APP/PS1 transgenic mice

H. Tanila, B. Ray, Demao Chen, 2010, Journal of neuroscience research.

Thin, stubby or mushroom: spine pathology in Alzheimer's disease.

D. Lahiri, R. Brandt, C. Tackenberg, 2009, Current Alzheimer research.

Late-onset Alzheimer's disease, heating up and foxed by several proteins: pathomolecular effects of the aging process.

K. Nho, K. Shah, Bryan Maloney, 2014, Journal of Alzheimer's disease : JAD.

N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, vascular dementia and Parkinson's disease.

N. Greig, Xudong Huang, D. Lahiri, 2012, Current Alzheimer research.

Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories

R. Nitsch, D. Lahiri, U. Konietzko, 2010, Neurobiology of Aging.

The cholinergic agonist carbachol reduces intracellular beta-amyloid precursor protein in PC 12 and C6 cells.

M. Farlow, D. Lahiri, C. Nall, 1992, Biochemistry international.

PuF, an antimetastatic and developmental signaling protein, interacts with the Alzheimer’s amyloid-β precursor protein via a tissue-specific proximal regulatory element (PRE)

Bryan Maloney, D. Lahiri, J. Rogers, 2013, BMC Genomics.

Puf, an Antimetastatic and Developmental Signaling Protein, Interacts with the Alzheimer's Amyloid-² Precursor Protein via a Tissue-specific Proximal Regulatory Element (pre) Puf, an Antimetastatic and Developmental Signaling Protein, Interacts with the Alzheimer's Amyloid-β Precursor Protein via a

Bryan Maloney, D. Lahiri, Y. Ge, 2022 .

Biological Hallmarks of Cancer in Alzheimer’s Disease

A. Saykin, B. McDonald, K. Nudelman, 2019, Molecular Neurobiology.

Functional characterization of three single‐nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA–protein interactions

Bryan Maloney, D. Lahiri, J. Rogers, 2009, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics.

Blood biomarkers for memory: toward early detection of risk for Alzheimer disease, pharmacogenomics, and repurposed drugs

A. Shekhar, A. Saykin, A. Shekhar, 2019, Molecular Psychiatry.

Diversity of Molecular Factors in Alzheimer's Disease.

J. Dorszewska, D. Lahiri, 2020, Current Alzheimer research.

Molecular cloning of the promoter of the gene encoding the Rhesus monkey beta-amyloid precursor protein: structural characterization and a comparative study with other species.

D. Lahiri, W. Song, D. Lahiri, 1998, Gene.

P.5.b.004 Effects of memantine on the activity of secretase enzymes in the human neuroblastoma cells

D. Lahiri, G. Alley, P. Banerjee, 2006, European Neuropsychopharmacology.

Preclinical basis for the efficacy of memantine in Alzheimer’s disease

H. Tanila, J. Miguel-Hidalgo, D. Lahiri, 2005, Alzheimer's & Dementia.

P.4.012 Effect of memantine on levels of the amyloid beta peptide in cell cultures

M. Farlow, D. Lahiri, G. Alley, 2003, European Neuropsychopharmacology.

Manganese causes neurotoxic iron accumulation via translational repression of Amyloid Precursor Protein (APP) and H-Ferritin

Allegra T. Aron, D. Lahiri, J. Rogers, 2018 .

The seeds of its regulation: natural antisense transcripts as single-gene control switches in neurodegenerative disorders

Bryan Maloney, D. Lahiri, S. Counts, 2024, Ageing Research Reviews.