D. Hanger

发表

Roles of tau protein in health and disease

Wendy Noble, Tong Guo, W. Noble, 2017, Acta Neuropathologica.

Collapsin response mediator protein‐2 hyperphosphorylation is an early event in Alzheimer’s disease progression

A. Verkhratsky, J. Richardson, F. LaFerla, 2007, Journal of neurochemistry.

Membrane association and release of wild-type and pathological tau from organotypic brain slice cultures

Matthew A. Wade, W. Noble, D. Hanger, 2017, Cell Death & Disease.

Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a “P301L” tau knockin mouse

S. Andrews, M. Kerschensteiner, T. Misgeld, 2012, Neurobiology of Aging.

Induction of neuronal death by α‐synuclein

A. Davies, D. Hanger, V. Buchman, 2000, The European journal of neuroscience.

Tau in Alzheimer's disease and Down's syndrome is insoluble and abnormally phosphorylated.

N. Cairns, P. Luthert, D. Hanger, 1991, The Biochemical journal.

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase

J. Woodgett, D. Hanger, J. Brion, 1992, Neuroscience Letters.

Direct analysis of tau from PSP brain identifies new phosphorylation sites and a major fragment of N‐terminally cleaved tau containing four microtubule‐binding repeats

D. Hanger, B. Anderton, S. Wray, 2008, Journal of neurochemistry.

The Importance of Tau Phosphorylation for Neurodegenerative Diseases

S. Lovestone, W. Noble, D. Hanger, 2013, Front. Neurol..

The microtubule-associated protein tau is also phosphorylated on tyrosine.

C. Duyckaerts, W. Noble, D. Hanger, 2009, Journal of Alzheimer's disease : JAD.

Familial Alzheimer's disease with the amyloid precursor protein position 717 mutation and sporadic Alzheimer's disease have the same cytoskeletal pathology

P. Lantos, M. Rossor, P. Luthert, 1992, Neuroscience Letters.

The Kinase Fyn As a Novel Intermediate in l-DOPA-Induced Dyskinesia in Parkinson’s Disease

D. Hanger, O. Gershanik, I. Taravini, 2017, Molecular Neurobiology.

Characterization of a Partial cDNA Specific for the High Molecular Weight Microtubule-Associated Protein MAP2 That Encodes Epitopes Shared with Paired Helical Filaments of Alzheimer's Disease

D. Hanger, J. Brion, B. Anderton, 1990 .

Tau in Alzheimer neurofibrillary tangles. N- and C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation site.

D. Hanger, J. Brion, B. Anderton, 1991, The Biochemical journal.

A68 proteins in Alzheimer's disease are composed of several tau isoforms in a phosphorylated state which affects their electrophoretic mobilities.

D. Hanger, J. Brion, B. Anderton, 1991, The Biochemical journal.

The phosphorylation state of the microtubule-associated protein tau as affected by glutamate, colchicine and beta-amyloid in primary rat cortical neuronal cultures.

C. Miller, D. Hanger, J. Brion, 1995, The Biochemical journal.

Oxidative stress induces dephosphorylation of tau in rat brain primary neuronal cultures.

D. Hanger, J. Brion, D. Davis, 1997, Journal of neurochemistry.

BIN1 protein loss in Alzheimer’s disease promotes synaptic tau accumulation and disrupts tau release

C. Troakes, W. Noble, D. Hanger, 2020 .

Molecular motors implicated in the axonal transport of tau and α-synuclein

W. Noble, D. Hanger, B. Anderton, 2005, Journal of Cell Science.

Characterisation of tau in the human and rodent enteric nervous system under physiological conditions and in tauopathy

Matthew A. Wade, W. Noble, D. Hanger, 2018, Acta neuropathologica communications.

Dynamic association of tau with neuronal membranes is regulated by phosphorylation

W. Noble, D. Hanger, K. Philpott, 2012, Neurobiology of Aging.

Kinase activities increase during the development of tauopathy in htau mice

W. Noble, D. Hanger, I. Kelleher, 2007, Journal of neurochemistry.

Tau pathology in a case of familial Alzheimer's disease with a valine to glycine mutation at position 717 in the amyloid precursor protein

D. Neary, D. Mann, D. Hanger, 1992, Neuroscience Letters.

MOLECULAR AND CELLULAR-CHANGES ASSOCIATED WITH NEUROFIBRILLARY TANGLES AND SENILE PLAQUES

D. Hanger, A. Probst, J. Gallo, 1990 .

A cDNA Encodes Epitopes Shared Between Microtubule-Associated Protein MAP2 and Alzheimer Neurofibrillary Tangles: In Situ Hybridization and Immunocytochemistry

D. Hanger, J. Brion, B. Anderton, 1989 .

Subject Index Vol. 1, 1990

K. Blennow, M. Folstein, C. Robinette, 1990 .

Pathological, clinical and genetic heterogeneity in progressive supranuclear palsy.

T Lashley, A J Lees, C Strand, 2002, Brain : a journal of neurology.

Minocycline as a potential therapeutic agent in neurodegenerative disorders characterized by protein misfolding

W. Noble, D. Hanger, C. Garwood, 2009, Prion.

Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons

D. Hanger, J. Gilley, K. D. De Vos, 2016, Neurobiology of Disease.

NUB1 modulation of GSK3 beta reduces tau aggregation

D. Hanger, M. Cheetham, M. Groettrup, 2012 .

The Disease Associated Tau35 Fragment has an Increased Propensity to Aggregate Compared to Full-Length Tau

Youssra K Al-Hilaly, A. Pastore, L. Serpell, 2021, bioRxiv.

Functional implications of the association of tau with the plasma membrane.

D. Hanger, A. Pooler, 2010, Biochemical Society transactions.

Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice

D. Hanger, J. Gilley, M. Coleman, 2016, Neurobiology of Aging.

Pathological lesions of Alzheimer's disease and dementia with Lewy bodies brains exhibit immunoreactivity to an ATPase that is a regulatory subunit of the 26S proteasome

J. Lowe, D. Hanger, R. Mayer, 1996, Neuroscience Letters.

The complex relationship between soluble and insoluble tau in tauopathies revealed by efficient dephosphorylation and specific antibodies

A. Lees, T. Révész, A. Lees, 2002, FEBS letters.

Molecular motors implicated in the axonal transport of tau and alpha-synuclein.

W. Noble, D. Hanger, B. Anderton, 2005, Journal of cell science.

Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau

W. Noble, D. Hanger, P. Derkinderen, 2011, The FEBS journal.

Phosphorylation of tau by cyclic-AMP-dependent protein kinase.

M. Goedert, D. Hanger, J. Robertson, 1993, Dementia.

Fluconazole and testosterone: in vivo and in vitro studies

D. Hanger, S. Jevons, J. Shaw, 1988, Antimicrobial Agents and Chemotherapy.

DEPARTMENT OF SURGERY PROTOCOL INDEX

C. Troakes, W. Noble, D. Hanger, 2013 .

Tau cleavage and tau aggregation in neurodegenerative disease.

D. Hanger, S. Wray, 2010, Biochemical Society transactions.

Tau phosphorylation in Alzheimer's disease

D. Hanger, 2003 .

α-Synuclein binds to the ER–mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production

Michael J. Devine, W. Noble, D. Hanger, 2017, Acta Neuropathologica.

Tau‐mediated synaptic dysfunction is coupled with HCN channelopathy

K. Staras, C. Troakes, L. Serpell, 2020, bioRxiv.

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease.

W. Noble, D. Hanger, B. Anderton, 2009, Trends in molecular medicine.

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells

Simon Lovestone, James R. Woodgett, S. Lovestone, 1994, Current Biology.

A role for tau at the synapse in Alzheimer's disease pathogenesis

W. Noble, D. Hanger, A. Pooler, 2014, Neuropharmacology.

Tau phosphorylation affects its axonal transport and degradation

Wendy Noble, W. Noble, D. Hanger, 2013, Neurobiology of Aging.

New Phosphorylation Sites Identified in Hyperphosphorylated Tau (Paired Helical Filament‐Tau) from Alzheimer's Disease Brain Using Nanoelectrospray Mass Spectrometry

W. Blackstock, D. Hanger, J. Betts, 1998, Journal of neurochemistry.

Phosphorylation Regulates Tau Interactions with Src Homology 3 Domains of Phosphatidylinositol 3-Kinase, Phospholipase Cγ1, Grb2, and Src Family Kinases*

M. Zvelebil, D. Hanger, P. Sheppard, 2008, Journal of Biological Chemistry.

Quantitative analysis of tau isoform transcripts in sporadic tauopathies.

P. Lantos, T. Révész, D. Hanger, 2005, Brain research. Molecular brain research.

ALS/FTD‐associated FUS activates GSK‐3β to disrupt the VAPB–PTPIP51 interaction and ER–mitochondria associations

C. Shaw, W. Noble, D. Hanger, 2016, EMBO reports.

Familial Danish Dementia: A Novel Form of Cerebral Amyloidosis Associated with Deposition of Both Amyloid‐Dan and Amyloid‐Beta

G. Plant, T. Révész, C. Strand, 2002, Journal of neuropathology and experimental neurology.

Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin

M. Ward, D. Hanger, H. Byers, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Functional Implications of Glycogen Synthase Kinase-3-Mediated Tau Phosphorylation

W. Noble, D. Hanger, 2011, International journal of Alzheimer's disease.

Mediators of tau phosphorylation in the pathogenesis of Alzheimer’s disease

W. Noble, D. Hanger, A. Seereeram, 2009, Expert review of neurotherapeutics.

Loss of the Alzheimer’s-linked bridging integrator 1 (BIN1) protein affects synaptic structure and disrupts tau localisation and release

C. Troakes, W. Noble, D. Hanger, 2019, bioRxiv.

Physiological release of endogenous tau is stimulated by neuronal activity

Wendy Noble, W. Noble, D. Hanger, 2013, EMBO reports.

Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer’s disease

W. Noble, D. Hanger, M. O'Neill, 2016, Acta Neuropathologica Communications.

Minocycline reduces the development of abnormal tau species in models of Alzheimer's disease

W. Noble, D. Hanger, B. Anderton, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Editorial: Tau Propagation Mechanisms: Cell Models, Animal Models, and Beyond

M. Hasegawa, D. Hanger, Y. Motoi, 2020, Frontiers in Neuroscience.

The ER-Mitochondria Tethering Complex VAPB-PTPIP51 Regulates Autophagy

W. Noble, D. Hanger, Christopher C. J. Miller, 2017, Current Biology.

A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies

W. Noble, D. Hanger, Chuay-Yeng Koo, 2018, Acta neuropathologica communications.

Inhibition of glycogen synthase kinase-3 by BTA-EG4 reduces tau abnormalities in an organotypic brain slice culture model of Alzheimer’s disease

W. Noble, D. Hanger, Ksenia Kurbatskaya, 2017, Scientific Reports.

Advances in tau-based drug discovery

W. Noble, D. Hanger, A. Pooler, 2011, Expert opinion on drug discovery.

Quantitation of glycogen synthase kinase‐3 sensitive proteins in neuronal membrane rafts

D. Hanger, B. Anderton, E. Schofield, 2009, Proteomics.

Hippocampal neurophysiology is modified by a disease-associated C-terminal fragment of tau protein

D. Hanger, Jon T. Brown, A. Randall, 2017, Neurobiology of Aging.

Tau protein in the glial cytoplasmic inclusions of multiple system atrophy can be distinguished from abnormal tau in Alzheimer's disease

P. Lantos, N. Cairns, S. Daniel, 1997, Neuroscience Letters.

Autopsy-confirmed familial early-onset Alzheimer disease caused by the l153V presenilin 1 mutation.

Nick C Fox, P. Lantos, J. Stevens, 2001, Archives of neurology.

The ultrastructural distribution of alpha-synuclein-like protein in normal mouse brain

S. Totterdell, G. Meredith, D. Hanger, 2004, Brain Research.

Isolation of detergent resistant microdomains from cultured neurons: detergent dependent alterations in protein composition

A. Thompson, D. Hanger, A. Hye, 2010, BMC Neuroscience.

Novel Phosphorylation Sites in Tau from Alzheimer Brain Support a Role for Casein Kinase 1 in Disease Pathogenesis*

Kit-Yi Leung, Selina Wray, M. Ward, 2007, Journal of Biological Chemistry.

Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain

Matthew A. Wade, C. Troakes, S. Al-Sarraj, 2016, Acta Neuropathologica Communications.

Membrane‐bound β‐amyloid oligomers are recruited into lipid rafts by a fyn‐dependent mechanism

D. Hanger, B. Anderton, R. Williamson, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Modification of the Drosophila model of in vivo Tau toxicity reveals protective phosphorylation by GSK3β

G. Tear, D. Hanger, R. Tuxworth, 2013, Biology Open.

Tyrosine 394 Is Phosphorylated in Alzheimer's Paired Helical Filament Tau and in Fetal Tau with c-Abl as the Candidate Tyrosine Kinase

Wendy Noble, Christof Lenz, Kit-Yi Leung, 2005, The Journal of Neuroscience.

Tau-mediated synaptic dysfunction is coupled with HCN channelopathy

K. Staras, C. Troakes, L. Serpell, 2023, bioRxiv.

Astrocytes and neuroinflammation in Alzheimer's disease.

M. Hutton, W. Noble, D. Hanger, 2014, Biochemical Society transactions.

Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule‐binding repeat domains as demonstrated by new specific monoclonal antibodies

J. Holton, A. Lees, T. Révész, 2003, Neuropathology and applied neurobiology.

Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate

T. Hortobágyi, Tong Guo, W. Noble, 2016, Brain : a journal of neurology.

A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response

Tong Guo, W. Noble, D. Hanger, 2019, Acta Neuropathologica Communications.

Synaptic Localisation of Tau.

W. Noble, D. Hanger, Despoina Goniotaki, 2019, Advances in experimental medicine and biology.

Parkinson's disease α-synuclein mutations exhibit defective axonal transport in cultured neurons

A. Davies, D. Hanger, V. Buchman, 2004, Journal of Cell Science.

Neurodegenerative changes including altered tau phosphorylation and neurofilament immunoreactivity in mice transgenic for the serine/threonine kinase mos

D. Hanger, Christopher C. J. Miller, J. Brion, 1996, Neurobiology of Aging.

Anti-Inflammatory Impact of Minocycline in a Mouse Model of Tauopathy

J. Cooper, W. Noble, D. Hanger, 2010, Front. Psychiatry.

Oxidative Stress Induces Dephosphorylation of τ in Rat Brain Primary Neuronal Cultures

D. Hanger, J. Brion, D. Davis, 1997 .

The microtubule-associated protein tau is phosphorylated by Syk

R. Geahlen, D. Hanger, P. Derkinderen, 2008, Biochimica et biophysica acta.

Expression and phosphorylation of a three-repeat isoform of tau in transfected non-neuronal cells.

K. Kosik, D. Hanger, J. Gallo, 1992, The Biochemical journal.

Intracellular and extracellular roles for tau in neurodegenerative disease.

Tong Guo, W. Noble, D. Hanger, 2014, Journal of Alzheimer's disease : JAD.

Sites of phosphorylation in tau and factors affecting their regulation.

S. Lovestone, W. Blackstock, D. Hanger, 2000, Biochemical Society symposium.

Prostate-derived Sterile 20-like Kinases (PSKs/TAOKs) Phosphorylate Tau Protein and Are Activated in Tangle-bearing Neurons in Alzheimer Disease*

C. Troakes, W. Noble, D. Hanger, 2013, The Journal of Biological Chemistry.

Transgenic mouse models of tauopathy in drug discovery.

W. Noble, D. Hanger, J. Gallo, 2010, CNS & neurological disorders drug targets.

Autophagy and lysosomal defects in cells expressing disease‐associated tau

Tong Guo, W. Noble, D. Hanger, 2021, Alzheimer's & dementia : the journal of the Alzheimer's Association.

Bridging integrator 1 protein loss in Alzheimer’s disease promotes synaptic tau accumulation and disrupts tau release

C. Troakes, W. Noble, D. Hanger, 2020, Brain communications.

NUB1 modulation of GSK3β reduces tau aggregation.

D. Hanger, M. Cheetham, M. Groettrup, 2012, Human molecular genetics.

NUB 1 modulation of GSK 3 b reduces tau aggregation

D. Hanger, M. Cheetham, M. Groettrup, 2012 .

Considerations for future tau-targeted therapeutics: can they deliver?

M. Jimenez-Sanchez, W. Noble, D. Hanger, 2020, Expert Opinion on Drug Discovery.

Critical residues involved in tau binding to fyn: implications for tau phosphorylation in Alzheimer’s disease

W. Noble, D. Hanger, M. O'Neill, 2016, Acta neuropathologica communications.

Chicken synucleins: cloning and expression in the developing embryo

A. Davies, D. Hanger, V. Buchman, 2000, Mechanisms of Development.

Differential involvement and heterogeneous phosphorylation of tau isoforms in progressive supranuclear palsy.

A. Lees, T. Révész, D. Hanger, 2004, Brain research. Molecular brain research.

Familial Alzheimer's disease with an APP717 point mutation and sporadic Alzheimer's disease have the same cytoskeletal pathology

P. Lantos, M. Rossor, P. Luthert, 1992, Neurobiology of Aging.

Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer’s disease

A. Jeromin, W. Noble, D. Hanger, 2013, Aging cell.

Identifying Novel Candidates for Re-Purposing as Potential Therapeutic Agents for Alzheimer’s disease

S. Thuret, D. Hanger, C. Ballard, 2019, bioRxiv.

Behavioral effects of dopamine agonists and antagonists in MPTP-lesioned D3 receptor knockout mice

D. Hanger, J. Joyce, Jeffrey N Joyce, 2003, Pharmacology Biochemistry and Behavior.

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture

W Noble, W. Noble, D. Hanger, 2011, Cell Death and Disease.

P2X7R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes

C. Troakes, M. Ruepp, W. Noble, 2023, Brain, Behavior, and Immunity.

A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies

W. Noble, D. Hanger, Chuay-Yeng Koo, 2018, Acta Neuropathologica Communications.

Hippocampal neurophysiology is modified by a disease-associated C-terminal fragment of tau protein

D. Hanger, Jon T. Brown, A. Randall, 2017, Neurobiology of Aging.

P2X7R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes

C. Troakes, M. Ruepp, W. Noble, 2023, Brain, Behavior, and Immunity.

Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau

W. Noble, D. Hanger, P. Derkinderen, 2011, The FEBS journal.

Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons

D. Hanger, J. Gilley, K. D. De Vos, 2016, Neurobiology of Disease.

Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a “P301L” tau knockin mouse

S. Andrews, M. Kerschensteiner, T. Misgeld, 2012, Neurobiology of Aging.

Key issues in the acquisition and analysis of qualitative and quantitative mass spectrometry data for peptide-centric proteomic experiments

Andrew J. Thompson, A. Thompson, D. Hanger, 2012, Amino Acids.

Artificial intelligence for neurodegenerative experimental models

W. Noble, D. Hanger, I. Lourida, 2023, Alzheimer's & dementia : the journal of the Alzheimer's Association.

Barcodes distinguishing morphology of neuronal tauopathy

D. Hanger, Despoina Goniotaki, Alain Goriely, 2023, Physical Review Research.

Regulation of tau phosphorylation in normal and diseased cells.

H. Wiśniewski, B. Winblad, S. Lovestone, 1999 .

Truncated tau interferes with the autophagy and endolysosomal pathway and results in lipid accumulation

Tong Guo, D. Hanger, P. Gomez-Suaga, 2024, Cellular and molecular life sciences : CMLS.

Mislocalization of neuronal tau in the absence of tangle pathology in phosphomutant tau knockin mice

D. Hanger, J. Gilley, M. Coleman, 2016, Neurobiology of Aging.