K. Utzschneider

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Mechanisms linking obesity to insulin resistance and type 2 diabetes

S. Kahn, R. Hull, K. Utzschneider, 2006, Nature.

Review: The role of insulin resistance in nonalcoholic fatty liver disease.

S. Kahn, K. Utzschneider, 2006, The Journal of clinical endocrinology and metabolism.

Dietary Acid Load is Associated With Serum Bicarbonate but not Insulin Sensitivity in Chronic Kidney Disease.

B. Kestenbaum, I. D. de Boer, J. Himmelfarb, 2016, Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.

Long-term treatment with rosiglitazone and metformin reduces the extent of, but does not prevent, islet amyloid deposition in mice expressing the gene for human islet amyloid polypeptide.

S. Kahn, R. Hull, K. Utzschneider, 2005, Diabetes.

An examination of β‐cell function measures and their potential use for estimating β‐cell mass

S. Kahn, K. Utzschneider, M. Faulenbach, 2008, Diabetes, obesity & metabolism.

Impact of intra-abdominal fat and age on insulin sensitivity and beta-cell function.

S. Kahn, R. Hull, K. Utzschneider, 2004, Diabetes.

Insulin action and beta-cell function : role in metabolic regulation

S. Kahn, K. Utzschneider, 2010 .

Cocaine Intoxication and Thyroid Storm

K. Utzschneider, Mary E. Lacy, 2014, Journal of investigative medicine high impact case reports.

Precision and Accuracy of Hyperglycemic Clamps in a Multicenter Study.

S. Caprio, M. Cree‐Green, K. Nadeau, 2021, American journal of physiology. Endocrinology and metabolism.

Physical activity and metabolic health in chronic kidney disease: a cross-sectional study

B. Kestenbaum, C. Robinson-Cohen, I. D. de Boer, 2016, BMC Nephrology.

The kidney's role in systemic metabolism-still much to learn.

I. D. de Boer, K. Utzschneider, 2017, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Paricalcitol does not improve glucose metabolism in patients with stage 3-4 chronic kidney disease

B. Kestenbaum, I. D. de Boer, A. Hoofnagle, 2012, Kidney international.

Oral Disposition Index Predicts the Development of Future Diabetes Above and Beyond Fasting and 2-h Glucose Levels

S. Kahn, E. Boyko, K. Utzschneider, 2009, Diabetes Care.

Dairy fat intake is associated with glucose tolerance, hepatic and systemic insulin sensitivity, and liver fat but not β-cell function in humans.

James E. Nelson, M. Yeh, K. Kowdley, 2014, The American journal of clinical nutrition.

Effect of Dietary Glycemic Index on β-Cell Function in Prediabetes: A Randomized Controlled Feeding Study

M. Neuhouser, K. Utzschneider, Kara L. Breymeyer, 2022, Nutrients.

Gestational Diabetes or Lesser Degrees of Glucose Intolerance and Risk of Preeclampsia

K. Newton, S. Heckbert, S. Kahn, 2011, Hypertension in pregnancy.

Reduced β-cell function and risk of retinopathy: What's the connection?

K. Utzschneider, 2021, Journal of Diabetes and its Complications.

β‐cells in youth with impaired glucose tolerance or early type 2 diabetes secrete more insulin and are more responsive than in adults

T. Buchanan, S. Caprio, M. Cree‐Green, 2020, Pediatric diabetes.

Impaired counterregulatory responses to hypoglycaemia following oral glucose in adults with cystic fibrosis

S. Kahn, E. Boyko, K. Utzschneider, 2020, Diabetologia.

Hereditary hemochromatosis and diabetes mellitus: implications for clinical practice

K. Kowdley, K. Utzschneider, 2010, Nature Reviews Endocrinology.

Association of glycemia with insulin sensitivity and β-cell function in adults with early type 2 diabetes on metformin alone.

P. Raskin, F. Ismail-Beigi, S. Kahn, 2021, Journal of diabetes and its complications.

Non‐alcoholic fatty liver disease as an independent manifestation of the metabolic syndrome: Results of a US national survey in three ethnic groups

E. Boyko, K. Utzschneider, G. Ioannou, 2013, Journal of gastroenterology and hepatology.

Plasma pancreatic polypeptide levels are associated with differences in body fat distribution in human subjects

S. Kahn, K. Utzschneider, J. Tong, 2007, Diabetologia.

Genetic background determines the extent of islet amyloid formation in human islet amyloid polypeptide transgenic mice.

S. Kahn, R. Hull, K. Utzschneider, 2005, American journal of physiology. Endocrinology and metabolism.

Islet Autoimmunity in Adults With Impaired Glucose Tolerance and Recently Diagnosed, Treatment Naïve Type 2 Diabetes in the Restoring Insulin SEcretion (RISE) Study

T. Buchanan, K. Nadeau, S. Kahn, 2021, Frontiers in Immunology.

Resistin is not associated with insulin sensitivity or the metabolic syndrome in humans

S. Kahn, R. Hull, K. Utzschneider, 2005, Diabetologia.

Liver Fat Reduction After Gastric Banding and Associations with Changes in Insulin Sensitivity and β‐Cell Function

K. Nayak, T. Buchanan, S. Caprio, 2021, Obesity.

OGTT Glucose Response Curves, Insulin Sensitivity, and β-Cell Function in RISE: Comparison Between Youth and Adults at Randomization and in Response to Interventions to Preserve β-Cell Function

S. Caprio, K. Nadeau, S. Kahn, 2021, Diabetes Care.

Hepatic Insulin Extraction in NAFLD Is Related to Insulin Resistance Rather Than Liver Fat Content.

S. Kahn, K. Utzschneider, D. Polidori, 2019, The Journal of clinical endocrinology and metabolism.

On the causal relationships between hyperinsulinaemia, insulin resistance, obesity and dysglycaemia in type 2 diabetes: Reply to Johnson JD [letter]

S. Kahn, K. Utzschneider, N. Esser, 2021, Diabetologia.

Two-year treatment with metformin during puberty does not preserve β-cell function in youth with obesity.

K. Nadeau, L. Pyle, K. Utzschneider, 2021, The Journal of clinical endocrinology and metabolism.

Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes.

M. Cnop, S. Kahn, E. Boyko, 2007, Diabetes care.

Within-subject variability of measures of beta cell function derived from a 2 h OGTT: implications for research studies

S. Kahn, K. Utzschneider, A. Mari, 2007, Diabetologia.

Oral Disposition Index Predicts the Development of Future Diabetes Above and Beyond Fasting and 2-h Glucose Levels

S. Kahn, E. Boyko, K. Utzschneider, 2009, Diabetes Care.

Identification of the Amyloid-Degrading Enzyme Neprilysin in Mouse Islets and Potential Role in Islet Amyloidogenesis

S. Kahn, R. Hull, K. Utzschneider, 2007, Diabetes.

Glucose- and time-dependence of islet amyloid formation in vitro.

S. Kahn, R. Hull, K. Utzschneider, 2007, Biochemical and biophysical research communications.

SE. Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels. Diabetes Care 2009;32:335―341

S. Kahn, E. Boyko, K. Utzschneider, 2009 .

Ethnic differences in hepatic and systemic insulin sensitivity and their associated determinants in obese black and white South African women

E. Lambert, T. Olsson, S. Kahn, 2015, Diabetologia.

Response to Letter to the Editor: Hepatic insulin extraction in NAFLD is related to insulin resistance rather than liver fat content.

S. Kahn, K. Utzschneider, D. Polidori, 2019, The Journal of clinical endocrinology and metabolism.

The Impact of Insulin Resistance on Hepatic Fibrosis among United States Adults with Non-Alcoholic Fatty Liver Disease: NHANES 2017 to 2018

K. Utzschneider, L. Beste, J. Bae, 2022, Endocrinology and metabolism.

Association of Baseline Characteristics With Insulin Sensitivity and β-Cell Function in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study Cohort

R. DeFronzo, W. Herman, F. Ismail-Beigi, 2020, Diabetes Care.

Conjugated Estrogens and Bazedoxifene Improve β Cell Function in Obese Menopausal Women

K. Utzschneider, V. Fonseca, J. Gautier, 2019, Journal of the Endocrine Society.

Weight loss and β‐cell responses following gastric banding or pharmacotherapy in adults with impaired glucose tolerance or type 2 diabetes: a randomized trial

T. Buchanan, S. Caprio, K. Nadeau, 2022, Obesity.

The impact of obesity on insulin sensitivity and secretion during pubertal progression: a longitudinal study.

K. Nadeau, L. Pyle, K. Utzschneider, 2020, The Journal of clinical endocrinology and metabolism.

Stimulus specificity of defects in counterregulatory hormone secretion in insulin-dependent diabetes mellitus

K. Utzschneider, B. Kinsley, D. Simonson, 1994 .

The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose.

J. Holst, S. Kahn, K. Utzschneider, 2008, Diabetes care.

Adipocytokines as features of the metabolic syndrome determined using confirmatory factor analysis.

P. Woudstra, J. Meigs, A. Chait, 2013, Annals of epidemiology.

Baseline Predictors of Glycemic Worsening in Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes in the Restoring Insulin Secretion (RISE) Study

T. Buchanan, S. Caprio, K. Nadeau, 2021, Diabetes Care.

The antioxidant N-Acetylcysteine does not improve glucose tolerance or β-cell function in type 2 diabetes.

K. Utzschneider, A. V. von Frankenberg, Magdalena A. Szkudlinska, 2016, Journal of diabetes and its complications.

Diet-induced weight loss is associated with an improvement in beta-cell function in older men.

R. Schwartz, S. Kahn, K. Utzschneider, 2004, The Journal of clinical endocrinology and metabolism.

Impact of Intra-Abdominal Fat and Age on Insulin Sensitivity and β-Cell Function

S. Kahn, R. Hull, K. Utzschneider, 2004 .

Complex Distribution, Not Absolute Amount of Adiponectin, Correlates with Thiazolidinedione-mediated Improvement in Insulin Sensitivity*

John A Wagner, Margaret S. Wu, T. Buchanan, 2004, Journal of Biological Chemistry.

Effects of Sex and Hormone Replacement Therapy Use on the Prevalence of Isolated Impaired Fasting Glucose and Isolated Impaired Glucose Tolerance in Subjects With a Family History of Type 2 Diabetes

S. Kahn, E. Boyko, K. Utzschneider, 2006, Diabetes.

Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome.

Jane B Shofer, S. Kahn, R. Hull, 2004, Diabetes.

IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes

Darrell M. Wilson, J. Gaglia, P. Raskin, 2021, JCI insight.

Association of Self-Reported Sleep and Circadian Measures With Glycemia in Adults With Prediabetes or Recently Diagnosed Untreated Type 2 Diabetes

E. van Cauter, K. Nadeau, K. Utzschneider, 2019, Diabetes Care.

Insulin Resistance is the Best Predictor of the Metabolic Syndrome in Subjects With a First‐Degree Relative With Type 2 Diabetes

S. Kahn, E. Boyko, K. Utzschneider, 2010, Obesity.

Interactions between genetic background, insulin resistance and β‐cell function

S. Kahn, K. Utzschneider, L. Wright, 2012, Diabetes, obesity & metabolism.

Mechanisms Linking the Gut Microbiome and Glucose Metabolism.

K. Utzschneider, C. Damman, M. Hullar, 2016, The Journal of clinical endocrinology and metabolism.

Measurement of insulin resistance in chronic kidney disease

I. D. de Boer, H. Pham, K. Utzschneider, 2011, Current opinion in nephrology and hypertension.

The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality

S. Kahn, R. Hull, K. Utzschneider, 2009, Diabetologia.

β‐Cell Dysfunction in Type 2 Diabetes

S. Kahn, K. Utzschneider, 2003 .

Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex

M. Cnop, S. Kahn, E. Boyko, 2003, Diabetologia.

Early beta cell dysfunction vs insulin hypersecretion as the primary event in the pathogenesis of dysglycaemia

S. Kahn, K. Utzschneider, N. Esser, 2020, Diabetologia.

Normal Insulin Secretion in Humans

D. Porte, S. Kahn, K. Utzschneider, 2003 .

Relationship between serum circulating insulin‐like growth factor‐1 and liver fat in the United States

E. Boyko, K. Utzschneider, G. Ioannou, 2014, Journal of gastroenterology and hepatology.

Serum ferritin is associated with non-alcoholic fatty liver disease and decreased Β-cell function in non-diabetic men and women.

James E. Nelson, A. Bertoldo, S. Kahn, 2014, Journal of diabetes and its complications.

The impact of diets rich in low-fat or full-fat dairy on glucose tolerance and its determinants: a randomized controlled trial.

K. Utzschneider, S. Holte, M. Kratz, 2020, The American journal of clinical nutrition.

Body mass index is associated with increased creatinine clearance by a mechanism independent of body fat distribution.

Edward J Boyko, I. D. de Boer, S. Kahn, 2009, The Journal of clinical endocrinology and metabolism.

The association of sleep disturbances with glycemia and obesity in youth at risk for or with recently diagnosed type 2 diabetes

E. van Cauter, K. Nadeau, K. Utzschneider, 2019, Pediatric diabetes.

Ethnic differences in serum lipoproteins and their determinants in South African women.

E. Lambert, T. Olsson, S. Kahn, 2010, Metabolism: clinical and experimental.

Impact of low-fat and full-fat dairy foods on fasting lipid profile and blood pressure: exploratory endpoints of a randomized controlled trial.

K. Utzschneider, S. Holte, M. Kratz, 2021, The American journal of clinical nutrition.

Insulin Response in Relation to Insulin Sensitivity

E. Lambert, T. Olsson, B. Walker, 2009, Diabetes Care.

Differential Effects of Abdominal Adipose Tissue Distribution on Insulin Sensitivity in Black and White South African Women

E. Lambert, T. Olsson, B. Walker, 2009, Obesity.

Differential Effects of a bdominal a dipose t issue Distribution on Insulin s ensitivity in Black and White s outh a frican Women

E. Lambert, T. Olsson, B. Walker, 2009 .

Relationship Between Chronic Kidney Disease, Glucose Homeostasis, and Plasma Osteocalcin Carboxylation and Fragmentation.

S. Booth, B. Kestenbaum, I. D. de Boer, 2020, Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.

Intraabdominal fat, insulin sensitivity, and cardiovascular risk factors in postpartum women with a history of preeclampsia.

D. Leotta, K. Utzschneider, J. Brunzell, 2015, American journal of obstetrics and gynecology.

Preeclampsia and Risk of Developing Subsequent Diabetes

K. Newton, S. Heckbert, S. Kahn, 2009, Hypertension in pregnancy.

Chronic kidney disease attenuates the plasma metabolome response to insulin.

B. Kestenbaum, I. D. de Boer, S. Kahn, 2018, JCI insight.

Treatment with thiazolidinediones

S. Kahn, K. Utzschneider, S. Suvag, 2013 .

Impact of differences in fasting glucose and glucose tolerance on the hyperbolic relationship between insulin sensitivity and insulin responses.

S. Kahn, R. Hull, K. Utzschneider, 2006, Diabetes care.

Sodium-Glucose Cotransporter-2 inhibitors and Cancer Outcomes: a systematic review and meta-analysis of randomized controlled trials.

E. Boyko, K. Utzschneider, F. Gerchman, 2023, Diabetes research and clinical practice.

A reduced-fat diet and aerobic exercise in Japanese Americans with impaired glucose tolerance decreases intra-abdominal fat and improves insulin sensitivity but not beta-cell function.

R. Schwartz, S. Kahn, E. Boyko, 2005, Diabetes.

Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: evidence for specificity of impaired beta cell adaptation

S. Kahn, R. Hull, K. Utzschneider, 2005, Diabetologia.

Small changes in glucose variability induced by low and high glycemic index diets are not associated with changes in β-cell function in adults with pre-diabetes.

K. Newton, M. Neuhouser, K. Utzschneider, 2020, Journal of diabetes and its complications.

Review of methods for measuring β‐cell function: Design considerations from the Restoring Insulin Secretion (RISE) Consortium

P. Savage, T. Buchanan, S. Caprio, 2018, Diabetes, obesity & metabolism.

Evidence That Hypothalamic Gliosis Is Related to Impaired Glucose Homeostasis in Adults With Obesity.

K. Utzschneider, E. Schur, S. Melhorn, 2021, Diabetes care.

Hyperglucagonemia Does Not Explain the β-Cell Hyperresponsiveness and Insulin Resistance in Dysglycemic Youth Compared With Adults: Lessons From the RISE Study

T. Buchanan, S. Caprio, K. Nadeau, 2021, Diabetes Care.

A high-fat, high-saturated fat diet decreases insulin sensitivity without changing intra-abdominal fat in weight-stable overweight and obese adults

K. Utzschneider, Xiaoling Song, M. Kratz, 2017, European Journal of Nutrition.

Beneficial effect of a weight-stable, low-fat/low-saturated fat/low-glycaemic index diet to reduce liver fat in older subjects

S. Craft, K. Utzschneider, Matthew Arbuckle, 2012, British Journal of Nutrition.

Shape of the OGTT glucose response curve: relationship with β-cell function and differences by sex, race, and BMI in adults with early type 2 diabetes treated with metformin

P. Raskin, F. Ismail-Beigi, S. Kahn, 2021, BMJ Open Diabetes Research & Care.

Impaired Glucose and Insulin Homeostasis in Moderate-Severe CKD.

B. Kestenbaum, I. D. de Boer, T. Ikizler, 2016, Journal of the American Society of Nephrology : JASN.

Preeclampsia and Risk of Developing Subsequent

K. Newton, S. Heckbert, S. Kahn, 2009 .

Case Presentation Cocaine Intoxication and Thyroid Storm: Similarity in Presentation and Implications for Treatment

K. Utzschneider, Mary E. Lacy, 2022 .

Impact of differences in glucose tolerance on the prevalence of a negative insulinogenic index.

S. Haffner, S. Kahn, E. Boyko, 2013, Journal of diabetes and its complications.

Colesevelam Improves Oral but Not Intravenous Glucose Tolerance by a Mechanism Independent of Insulin Sensitivity and β-Cell Function

S. Kahn, K. Utzschneider, S. Marcovina, 2012, Diabetes Care.

Association of Habitual Daily Physical Activity With Glucose Tolerance and β-Cell Function in Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes From the Restoring Insulin Secretion (RISE) Study

K. Utzschneider, E. Barengolts, A. Tjaden, 2019, Diabetes Care.

Intra-abdominal fat accumulation predicts the development of the metabolic syndrome in non-diabetic Japanese-Americans

S. Kahn, E. Boyko, K. Utzschneider, 2007, Diabetologia.

Superiority of the Modification of Diet in Renal Disease equation over the Cockcroft-Gault equation in screening for impaired kidney function in Japanese Americans.

S. Kahn, E. Boyko, R. Hull, 2007, Diabetes research and clinical practice.

Effects of Dietary Fat and Saturated Fat Content on Liver Fat and Markers of Oxidative Stress in Overweight/Obese Men and Women under Weight-Stable Conditions

K. Utzschneider, M. Kratz, A. V. von Frankenberg, 2014, Nutrients.

The impact of low-fat and full-fat dairy foods on symptoms of gastroesophageal reflux disease: an exploratory analysis based on a randomized controlled trial

T. Vaughan, K. Utzschneider, M. Kratz, 2022, European Journal of Nutrition.

Reduced adipogenic gene expression in thigh adipose tissue precedes human immunodeficiency virus-associated lipoatrophy.

B. van Yserloo, S. Kahn, J. Hughes, 2008, The Journal of clinical endocrinology and metabolism.

Chronic kidney disease and obesity bias surrogate estimates of insulin sensitivity compared with the hyperinsulinemic euglycemic clamp.

B. Kestenbaum, I. D. de Boer, A. Hung, 2017, American journal of physiology. Endocrinology and metabolism.

Tubular Secretory Clearance is Associated with Whole-Body Insulin Clearance.

B. Kestenbaum, I. D. de Boer, S. Kahn, 2020, The Journal of clinical endocrinology and metabolism.

An Oral Disposition Index Predicts the Development of Future Diabetes Above and Beyond Fasting and 2-Hour Glucose Levels Short title: Oral Disposition Index Predicts Diabetes

S. Kahn, E. Boyko, K. Utzschneider, 2008 .

Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: I. Observations Using the Hyperglycemic Clamp

P. Savage, T. Buchanan, S. Caprio, 2018, Diabetes Care.

Impact of the Analytical Approach on the Reliability of MRI-Based Assessment of Hepatic Fat Content

N. Balu, K. Utzschneider, T. Randolph, 2020, Current developments in nutrition.

Differential Loss of β-cell Function in Youth vs. Adults Following Treatment Withdrawal in the Restoring Insulin Secretion (RISE) Study.

S. Caprio, M. Cree‐Green, K. Nadeau, 2021, Diabetes research and clinical practice.

Ethnic differences in serum lipoproteins and their determinants in South African women.

E. Lambert, T. Olsson, S. Kahn, 2010, Metabolism: Clinical and Experimental.

Stimulus specificity of defects in counterregulatory hormone secretion in insulin-dependent diabetes mellitus: effect of glycemic control.

K. Utzschneider, B. Kinsley, D. Simonson, 1994, The Journal of clinical endocrinology and metabolism.

Gestational Diabetes or Lesser Degrees of Glucose Intolerance and Risk of Preeclampsia

K. Newton, S. Heckbert, S. Kahn, 2011, Hypertension in Pregnancy.

GAD65Abs Are Not Associated With Beta-Cell Dysfunction in Patients With T2D in the GRADE Study

H. Florez, C. Hampe, K. Utzschneider, 2024, Journal of the Endocrine Society.

Chronic kidney disease attenuates the plasma metabolome response to insulin.

B. Kestenbaum, I. D. de Boer, S. Kahn, 2018, JCI insight.