S. George

发表

Spatial learning deficit in dopamine D(1) receptor knockout mice.

D. Sibley, P. Fletcher, B. O'dowd, 1999, European journal of pharmacology.

Discovery of a receptor related to the galanin receptors

B. O'dowd, G. O'neill, S. George, 1999, FEBS letters.

Novel GPCRs and their endogenous ligands: expanding the boundaries of physiology and pharmacology.

L. F. Kolakowski, B. O'dowd, S. George, 1999, Trends in pharmacological sciences.

The Dopamine D1–D2 Receptor Heteromer in Striatal Medium Spiny Neurons: Evidence for a Third Distinct Neuronal Pathway in Basal Ganglia

B. O'dowd, S. George, M. Perreault, 2011, Front. Neuroanat..

Insights into the Role of Dopamine Receptor Systems in Learning and Memory

B. O'dowd, M. El-Ghundi, S. George, 2007, Reviews in the neurosciences.

Modification of dopamine D(1) receptor knockout phenotype in mice lacking both dopamine D(1) and D(3) receptors.

P. Fletcher, B. O'dowd, M. El-Ghundi, 2000, European journal of pharmacology.

18F-MCL-524, an 18F-Labeled Dopamine D2 and D3 Receptor Agonist Sensitive to Dopamine: A Preliminary PET Study

C. Halldin, L. Farde, P. Seeman, 2014, The Journal of Nuclear Medicine.

Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1

Susan R. George, Philip Seeman, Roger K. Sunahara, 1991, Nature.

Dopamine D2 receptor dimers and receptor-blocking peptides.

P. Seeman, M. Brann, B. O'dowd, 1996, Biochemical and biophysical research communications.

Corticotropin-releasing hormone and dopamine release in healthy individuals

S. Houle, S. Kish, I. Boileau, 2017, Psychoneuroendocrinology.

Desensitization of the Dopamine D1 and D2 Receptor Hetero-Oligomer Mediated Calcium Signal by Agonist Occupancy of Either Receptor

B. O'dowd, S. George, C. H. So, 2007, Molecular Pharmacology.

Endogenous opioids are involved in the genetically determined high preference for ethanol consumption.

C. Naranjo, S. George, L. Roldan, 1991, Alcoholism, clinical and experimental research.

β-endorphin alters dopamine uptake by the dopamine neurons of the hypothalamus and striatum

S. George, G. V. Loon, G. R. Loon, 1982, Brain Research.

The fate of the internalized apelin receptor is determined by different isoforms of apelin mediating differential interaction with beta-arrestin.

B. O'dowd, S. George, S. Ferguson, 2010, Biochemical and biophysical research communications.

Dopamine Receptor Oligomerization Visualized in Living Cells*

B. O'dowd, A. Rashid, S. George, 2005, Journal of Biological Chemistry.

Dopamine D2 receptor dimers in human and rat brain

P. Seeman, B. O'dowd, S. George, 1998, FEBS letters.

Inhibition of cell surface expression by mutant receptors demonstrates that D2 dopamine receptors exist as oligomers in the cell.

H. Akil, B. O'dowd, S. George, 2000, Molecular pharmacology.

Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14.

Jilly F. Evans, C. Austin, T. Mcdonald, 1999, Biochemical and biophysical research communications.

The Role of Oligomerization in G Protein-Coupled Receptor Maturation

B. O'dowd, S. George, C. H. So, 2005 .

The splice variant D3nf reduces ligand binding to the D3 dopamine receptor: evidence for heterooligomerization.

B. O'dowd, S. George, Z. Xie, 2000, Brain research. Molecular brain research.

Phosphorylation and Palmitoylation of the Human D2L Dopamine Receptor in Sf9 Cells

M. Caron, M. Brann, B. O'dowd, 1994, Journal of neurochemistry.

Single or repeated mild stress increases synthesis and release of hypothalamic corticotropin-releasing factor

S. George, D. Haas, 1988, Brain Research.

Effect of dopaminergic and alpha-adrenergic modulation on corticotropin-releasing factor immunoreactivity in rat hypothalamus.

S. George, D. Haas, 1988, Canadian journal of physiology and pharmacology.

Gonadal regulation of corticotropin-releasing factor immunoreactivity in hypothalamus

S. George, D. Haas, 1988, Brain Research Bulletin.

Unravelling the roles of the apelin system: prospective therapeutic applications in heart failure and obesity.

B. O'dowd, S. George, Dennis K. Lee, 2006, Trends in pharmacological sciences.

Disruption of dopamine D1 receptor gene expression attenuates alcohol-seeking behavior.

D. Sibley, P. Fletcher, B. O'dowd, 1998, European journal of pharmacology.

Disruption of dopamine D receptor gene expression attenuates

D. Sibley, P. Fletcher, J. Drago, 1998 .

Dopamine D1 receptor distribution in Sf9 cells imaged by confocal microscopy: a quantitative evaluation.

J. Stevens, B. O'dowd, S. George, 1995, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Dopamine D1 receptor mutagenesis: role of amino acids in agonist and antagonist binding.

P. Seeman, B. O'dowd, S. George, 1993, Biochemical and biophysical research communications.

Continued discovery of ligands for G protein-coupled receptors.

B. O'dowd, S. George, Dennis K. Lee, 2003, Life sciences.

Discovery of three novel G-protein-coupled receptor genes.

H. Heng, L. F. Kolakowski, B. O'dowd, 1998, Genomics.

GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base

George Khelashvili, Kevin C. Dorff, Jufang Shan, 2010, Bioinform..

Non-amine-based dopamine transporter (reuptake) inhibitors retain properties of amine-based progenitors.

B. O'dowd, R. De La Garza, S. George, 2003, European journal of pharmacology.

Cloning, Expression, and Chromosomal Localization of the Human Uridine Nucleotide Receptor Gene (*)

J. T. Turner, H. Heng, B. O'dowd, 1995, The Journal of Biological Chemistry.

The effects of SMS 201-995 (sandostatin) on metabolic profiles in insulin-dependent diabetes mellitus.

B. Zinman, S. Shumak, S. George, 1989, The Journal of clinical endocrinology and metabolism.

Distinct distributions of mu, delta and kappa opioid receptor mRNA in rat brain.

B. O'dowd, S. George, Tuan V. Nguyen, 1994, Biochemical and biophysical research communications.

Cloning genes encoding receptors related to chemoattractant receptors.

H. Heng, L. F. Kolakowski, B. O'dowd, 1998, Genomics.

A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3.

H. Heng, B. O'dowd, S. George, 1996, Genomics.

Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition.

M. Caron, B. O'dowd, S. George, 1993, Biochemistry.

Measurement of methionine enkephalin and leucine enkephalin in rat brain regions by high-performance liquid chromatography with coulometric electrochemical detection.

S. George, C. Kim, R. Cheng, 1989, Journal of chromatography.

Neuropeptide Y administration acutely increases hypothalamic corticotropin-releasing factor immunoreactivity: lack of effect in other rat brain regions.

S. George, D. Haas, Susan R. George, 1987, Life sciences.

Cloning of human genes encoding novel G protein-coupled receptors.

H. Heng, L. Tsui, B. O'dowd, 1994, Genomics.

Dopamine receptor sites and states in human brain.

P. Seeman, S. George, K. Binkley, 1983, Journal of neural transmission. Supplementum.

Disruption of the mu-delta opioid receptor heteromer.

B. O'dowd, S. George, Xiaodong Ji, 2012, Biochemical and biophysical research communications.

Molecular Characterization and Expression of Cloned Human Galanin Receptors GALR2 and GALR3

L. F. Kolakowski, B. O'dowd, S. Kargman, 1998, Journal of neurochemistry.

Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1.

H. Heng, L. F. Kolakowski, B. O'dowd, 1997, Biochemical and biophysical research communications.

Enhanced Brain-Derived Neurotrophic Factor Signaling in the Nucleus Accumbens of Juvenile Rats

B. O'dowd, S. George, M. Perreault, 2013, Developmental Neuroscience.

Using Ligand-Induced Conformational Change to Screen for Compounds Targeting G-Protein-Coupled Receptors

B. O'dowd, S. George, R. Eglen, 2007, Journal of biomolecular screening.

B. O'dowd, S. George, Dennis K. Lee, 1999, Brain research. Molecular brain research.

Regulation of Anterior Pituitary D2 Dopamine Receptors by Magnesium and Sodium Ions

P. Seeman, S. George, Masayuki Watanabe, 1985, Journal of neurochemistry.

μ-δ opioid receptor heteromer-specific signaling in the striatum and hippocampus.

B. O'dowd, S. George, N. Kabli, 2014, Biochemical and biophysical research communications.

Dopamine D2 receptors in brain and anterior pituitary recognize agonist and antagonist actions of (−)-3-PPP

P. Seeman, S. George, M. Watanabe, 2005, Journal of Neural Transmission.

Separation and reformation of cell surface dopamine receptor oligomers visualized in cells.

B. O'dowd, S. George, Tuan V. Nguyen, 2011, European journal of pharmacology.

Agonist-Induced Cell Surface Trafficking of an Intracellularly Sequestered D1 Dopamine Receptor Homo-Oligomer

B. O'dowd, S. George, Michael M. C. Kong, 2006, Molecular Pharmacology.

Agonist-induced desensitization of dopamine D1 receptor-stimulated adenylyl cyclase activity is temporally and biochemically separated from D1 receptor internalization.

J. Stevens, B. O'dowd, S. George, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Neuropeptide Y-induced effects on hypothalamic corticotropin-releasing factor content and release are dependent on noradrenergic/adrenergic neurotransmission

S. George, D. Haas, 1989, Brain Research.

Reduced striatal dopamine D1–D2 receptor heteromer expression and behavioural subsensitivity in juvenile rats

B. O'dowd, S. George, M. Perreault, 2012, Neuroscience.

G-Protein-coupled receptor oligomerization and its potential for drug discovery

Susan R. George, B. O'dowd, S. George, 2002, Nature Reviews Drug Discovery.

D5 dopamine receptor carboxyl tail involved in D5-D2 heteromer formation.

B. O'dowd, S. George, Xiaodong Ji, 2013, Biochemical and biophysical research communications.

Two amino acids in each of D1 and D2 dopamine receptor cytoplasmic regions are involved in D1-D2 heteromer formation.

B. O'dowd, S. George, Xiaodong Ji, 2012, Biochemical and biophysical research communications.

Oligomerization of μ- and δ-Opioid Receptors

B. O'dowd, S. George, G. Varghese, 2000, The Journal of Biological Chemistry.

Resistance of the dopamine D2L receptor to desensitization accompanies the up-regulation of receptors on to the surface of Sf9 cells.

P. Seeman, B. O'dowd, S. George, 1997, Endocrinology.

Agonist-induced Desensitization of the μ Opioid Receptor Is Determined by Threonine 394 Preceded by Acidic Amino Acids in the COOH-terminal Tail*

B. O'dowd, S. George, Y. Pak, 1997, The Journal of Biological Chemistry.

Palmitoylation occurs at cysteine 347 and cysteine 351 of the dopamine D(1) receptor.

B. O'dowd, S. George, Z. Xie, 1999, European journal of pharmacology.

Agonist-induced, G protein-dependent and -independent down-regulation of the mu opioid receptor. The receptor is a direct substrate for protein-tyrosine kinase.

B. O'dowd, S. George, J. Wang, 1999, The Journal of biological chemistry.

Dopamine D2 Receptors in the Anterior Pituitary: A Single Population Without Reciprocal Antagonist/Agonist States

P. Seeman, S. George, Masayuki Watanabe, 1985, Journal of neurochemistry.

Estradiol or ovariectomy decreases crf synthesis in hypothalamus

S. George, D. Haas, 1989, Brain Research Bulletin.

Mapping studies of two G protein-coupled receptor genes: an amino acid difference may confer a functional variation between a human and rodent receptor.

B. O'dowd, S. George, A. Marchese, 1994, Biochemical and biophysical research communications.

Synthesis and Evaluation of Fluorinated Aporphines: Potential Positron Emission Tomography Ligands for D2 Receptors

P. Seeman, S. George, J. Neumeyer, 2011, ACS medicinal chemistry letters.

D2 dopamine receptor homodimerization is mediated by multiple sites of interaction, including an intermolecular interaction involving transmembrane domain 4.

B. O'dowd, S. George, Samuel P. Lee, 2003, Biochemistry.

The role of palmitoylation in directing dopamine D1 receptor internalization through selective endocytic routes.

B. O'dowd, S. George, Michael M. C. Kong, 2011, Biochemical and biophysical research communications.

Sandostatin® (SMS 201–995) Treatment of Acromegaly: Acute and Chronic Effects

S. George, 1988 .

Met-enkephalin-like immunoreactivity in neurointermediate pituitary is decreased by DA receptor stimulation

S. George, M. Kertesz, 1986, Peptides.

Agonist-independent Nuclear Localization of the Apelin, Angiotensin AT1, and Bradykinin B2 Receptors*

B. O'dowd, S. George, S. Chemtob, 2004, Journal of Biological Chemistry.

Dopamine receptors regulate Met-enkephalin content in pituitary

S. George, M. Kertesz, 1985, Brain Research.

G protein-coupled receptor-protein interactions

B. O'dowd, S. George, 2005 .

Met-enkephalin uptake by a synaptosome-enriched fraction of rat striatum

S. George, G. V. Loon, G. R. Loon, 1981, Neuroscience Letters.

Postnatal maternal deprivation and pubertal stress have additive effects on dopamine D2 receptor and CaMKII beta expression in the striatum

B. O'dowd, S. George, G. Novak, 2013, International Journal of Developmental Neuroscience.

Discovery and mapping of ten novel G protein-coupled receptor genes.

Jilly F. Evans, B. O'dowd, J. Evans, 2001, Gene.

Dopamine D2 receptor binding sites for agonists. A tetrahedral model.

J. Nilsson, P. Seeman, S. George, 1985, Molecular pharmacology.

Family 1 G protein-coupled receptor function in the CNS Insights from gene knockout mice

B. O'dowd, S. George, J. Karasinska, 2003, Brain Research Reviews.

Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties.

B. O'dowd, S. George, S R George, 2000, The Journal of biological chemistry.

Met-enkephalin concentrations in striatum respond reciprocally to alterations in dopamine neurotransmission

Susan R. George, S. George, Miriam Kertesz, 1987, Peptides.

Ontogenic profile of the expression of the mu opioid receptor gene in the rat telencephalon and diencephalon: an in situ hybridization study

B. O'dowd, S. George, R. Quirion, 2000, Journal of Chemical Neuroanatomy.

Dopamine D1-D2 Receptor Heteromer Regulates Signaling Cascades Involved in Addiction: Potential Relevance to Adolescent Drug Susceptibility

S. George, M. Perreault, Brian F. OʼDowd, 2014, Developmental Neuroscience.

Novel G-protein-coupled receptor genes expressed in the brain: continued discovery of important therapeutic targets

B. O'dowd, S. George, Dennis K. Lee, 2002, Expert opinion on therapeutic targets.

Prolactin increases the activity of tuberoinfundibular and nigroneostriatal dopamine neurons: Prolactin antiserum inhibits the haloperidol-induced increases in dopamine synthesis rates in median eminence and striatum of rats

S. George, A. Shum, G. V. Loon, 1983, Brain Research Bulletin.

Discovery of a novel member of the histamine receptor family.

V. Setola, B. Roth, D. A. Shapiro, 2001, Molecular pharmacology.

Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain.

H. Heng, B. O'dowd, S. George, 1999, Brain research. Molecular brain research.

D1–D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum

B. O'dowd, A. Rashid, M. El-Ghundi, 2007, Proceedings of the National Academy of Sciences.

Building a new conceptual framework for receptor heteromers.

Michel Bouvier, Graeme Milligan, Jonathan A Javitch, 2009, Nature chemical biology.

The identification of NP25: a novel protein that is differentially expressed by neuronal subpopulations.

B. O'dowd, S. George, C. Liew, 1994, Brain research. Molecular brain research.

Sex Differences in Dopamine Receptors and Relevance to Neuropsychiatric Disorders

S. George, M. Perreault, Olivia O F Williams, 2021, Brain sciences.

Characterization of the Human Cysteinyl Leukotriene 2 Receptor*

Jilly F. Evans, B. O'dowd, R. Stocco, 2000, The Journal of Biological Chemistry.

A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha.

Jilly F. Evans, Arthur S Slutsky, K. Siminovitch, 2003, Pharmacogenetics.

Orphan G protein-coupled receptors in the CNS.

B. O'dowd, J. Evans, S. George, 2001, Current opinion in pharmacology.

Identification of four novel human G protein-coupled receptors expressed in the brain.

B. O'dowd, S. George, M. Brown, 2001, Brain research. Molecular brain research.

A novel gene codes for a putative G protein‐coupled receptor with an abundant expression in brain

H. Heng, L. F. Kolakowski, B. O'dowd, 1996, FEBS letters.

A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11.

H. Heng, L. Tsui, J. Kennedy, 1993, Gene.

Advancing drug discovery for schizophrenia

J. Lieberman, P. Sullivan, S. Haggarty, 2011, Annals of the New York Academy of Sciences.

The human serotonin 5-hydroxytryptamine1D receptor pseudogene is transcribed.

T. Branchek, B. O'dowd, S. George, 1995, Gene.

Dopamine D1 and D2 Receptor Co-activation Generates a Novel Phospholipase C-mediated Calcium Signal*

B. O'dowd, A. Rashid, S. George, 2004, Journal of Biological Chemistry.

Isolation of three novel human genes encoding G protein-coupled receptors.

H. Heng, L. Tsui, B. O'dowd, 1995, DNA and cell biology.

Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations

E H Cook, E. Cook, D. Comings, 2000, Molecular Psychiatry.

Characterization of Apelin, the Ligand for the APJ Receptor

B. O'dowd, S. George, Dennis K. Lee, 2000, Journal of neurochemistry.

Heteromeric Dopamine Receptor Signaling Complexes: Emerging Neurobiology and Disease Relevance

B. O'dowd, S. George, M. Perreault, 2014, Neuropsychopharmacology.

Calcium signaling cascade links dopamine D1–D2 receptor heteromer to striatal BDNF production and neuronal growth

B. O'dowd, S. George, M. Perreault, 2009, Proceedings of the National Academy of Sciences.

Daily Δ9-Tetrahydrocannabinol and Withdrawal Increase Dopamine D1-D2 Receptor Heteromer to Mediate Anhedonia- and Anxiogenic-like Behavior Through a Dynorphin and Kappa Opioid Receptor Mechanism

S. George, B. Madras, A. Hasbi, 2022, Biological psychiatry global open science.

Daily D 9 -Tetrahydrocannabinol and Withdrawal Increase Dopamine D 1 -D 2 Receptor Heteromer to Mediate Anhedonia- and Anxiogenic-like Behavior Through a Dynorphin and Kappa Opioid Receptor Mechanism

S. George, B. Madras, A. Hasbi, 2022 .

Dopamine D1-D2 receptor heteromer expression in key brain regions of rat and higher species: Upregulation in rat striatum after cocaine administration

S. George, B. Madras, A. Hasbi, 2020, Neurobiology of Disease.

Disparate Effects of Lithium and a GSK-3 Inhibitor on Neuronal Oscillatory Activity in Prefrontal Cortex and Hippocampus

Susan R. George, S. George, Tuan V. Nguyen, 2018, Front. Aging Neurosci..

The atypical dopamine receptor agonist SKF 83959 enhances hippocampal and prefrontal cortical neuronal network activity in a rat model of cognitive dysfunction

A. Grace, S. George, M. Perreault, 2017, The European journal of neuroscience.

Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance

B. O'dowd, S. George, A. Hasbi, 2011, Molecular Brain.

Dopamine receptor activation inhibits estrogen-stimulated transforming growth factor-alpha gene expression and growth in anterior pituitary, but not in uterus.

S. George, S. Mueller, B. Borgundvaag, 1992, Endocrinology.

Characterization of a Novel Sphingosine 1-Phosphate Receptor, Edg-8*

B. O'dowd, M. Rigby, G. Mcallister, 2000, The Journal of Biological Chemistry.

Characterization of high affinity dopamine uptake into the dopamine neurons of the hypothalamus

S. George, G. V. Loon, G. R. Loon, 1982, Brain Research.

Estrogen regulation of rat anterior pituitary adenylate cyclase

S. George, B. Borgundvaag, 1988, Molecular and Cellular Endocrinology.

Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate.

D. Theodorescu, B. O'dowd, S. George, 2000, Molecular pharmacology.

Heterogeneous tissue-specific transcription of dopamine receptor subtype messenger RNA in rat brain.

B. O'dowd, S. George, L. Laurier, 1994, Brain research. Molecular brain research.

Dopamine receptor density, sensitivity and mRNA levels are altered following self-administration of cocaine in the rat

S. George, W. Corrigall, L. Laurier, 1994, Brain Research.

Dmc1 fluorescent foci in prophase I nuclei of diploid, triploid and hybrid lilies

S. George, Y. Hotta, K. Hiratsuka, 2002, Chromosoma.

Agonist-induced, G Protein-dependent and -independent Down-regulation of the μ Opioid Receptor

B. O'dowd, S. George, Jia Bei Wang, 1999, The Journal of Biological Chemistry.

Differential alpha-1 and alpha-2 adrenergic effects on hypothalamic corticotropin-releasing factor and plasma adrenocorticotropin

S. George, D. Haas, W. Sturtridge, 1990, Neuroscience.

Oligomerization of opioid receptors: generation of novel signaling units.

B. O'dowd, S. George, B. Levac, 2002, Current opinion in pharmacology.

Activation of calcium/calmodulin-dependent protein kinase IIα in the striatum by the heteromeric D1-D2 dopamine receptor complex

B. O'dowd, A. Rashid, S. George, 2010, Neuroscience.

Restoration of amphetamine-induced locomotor sensitization in dopamine D1 receptor-deficient mice

B. O'dowd, M. El-Ghundi, S. George, 2009, Psychopharmacology.

Deletion of dopamine D1 and D3 receptors differentially affects spontaneous behaviour and cocaine‐induced locomotor activity, reward and CREB phosphorylation

B. O'dowd, S. George, R. Cheng, 2005, The European journal of neuroscience.

Attenuation of sucrose reinforcement in dopamine D1 receptor deficient mice

B. O'dowd, M. El-Ghundi, S. George, 2003, The European journal of neuroscience.

Structure of Mammalian D1 and D5 Dopamine Receptors and Their Function and Regulation in Cells

B. O'dowd, S. George, L. Demchyshyn, 2003 .

Prolonged fear responses in mice lacking dopamine D1 receptor

B. O'dowd, M. El-Ghundi, S. George, 2001, Brain Research.

Modification of dopamine D1 receptor knockout phenotype in mice lacking both dopamine D1 and D3 receptors

P. Fletcher, B. O'dowd, M. El-Ghundi, 2000 .

Low endogenous dopamine function in brain predisposes to high alcohol preference and consumption: reversal by increasing synaptic dopamine.

C. Naranjo, B. O'dowd, S. George, 1995, The Journal of pharmacology and experimental therapeutics.

Genotypic differences in brain dopamine receptor function in the DBA/2J and C57BL/6J inbred mouse strains.

B. O'dowd, S. George, G. Ng, 1994, European journal of pharmacology.

Dopamine receptor agonist reduces ethanol self-administration in the ethanol-preferring C57BL/6J inbred mouse.

S. George, G. Ng, 1994, European journal of pharmacology.

The antipsychotic potential of l-stepholidine—a naturally occurring dopamine receptor D1 agonist and D2 antagonist

S. Kapur, J. Nobrega, S. Natesan, 2008, Psychopharmacology.

Discovery of a null mutation in a human trace amine receptor gene.

P. Muglia, J. Kennedy, B. O'dowd, 2003, Genomics.

Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis.

Philip Seeman, R. Palmiter, D. Grandy, 2005, Proceedings of the National Academy of Sciences of the United States of America.

TRH-R2 exhibits similar binding and acute signaling but distinct regulation and anatomic distribution compared with TRH-R1.

B. O'dowd, W. Huang, S. George, 2000, Molecular endocrinology.

Discovery of three novel orphan G-protein-coupled receptors.

H. Heng, B. O'dowd, S. George, 1999, Genomics.

Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base

Michel Bouvier, Susan R. George, Jonathan A. Javitch, 2007, BMC Bioinformatics.

Novel human G-protein-coupled receptors.

B. O'dowd, S. George, W. Vanti, 2003, Biochemical and biophysical research communications.

Polymorphisms of the D4 dopamine receptor alleles in chronic alcoholism.

Y. Israel, B. O'dowd, S. George, 1993, Biochemical and biophysical research communications.

Modification of the terminal residue of apelin-13 antagonizes its hypotensive action.

B. O'dowd, S. George, Dennis K. Lee, 2005, Endocrinology.

Striatal development involves a switch in gene expression networks, followed by a myelination event: Implications for neuropsychiatric disease

B. O'dowd, S. George, G. Novak, 2013, Synapse.

Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates intracellular calcium signaling by different mechanisms.

B. O'dowd, S. George, A. Hasbi, 2010, Current opinion in pharmacology.

Antidepressant-like and anxiolytic-like effects following activation of the μ-δ opioid receptor heteromer in the nucleus accumbens

B. O'dowd, S. George, G. Balboni, 2014, Molecular Psychiatry.

Mutation screening of the dopamine D1 receptor gene in Tourette's syndrome and alcohol dependent patients.

D. Comings, B. O'dowd, M. Thompson, 1998, American journal of medical genetics.

Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes.

H. Heng, L. F. Kolakowski, B. O'dowd, 1997, Gene.

A Transmembrane Domain-derived Peptide Inhibits D1 Dopamine Receptor Function without Affecting Receptor Oligomerization*

P. Seeman, B. O'dowd, S. George, 1998, The Journal of Biological Chemistry.

Opioids: molecular basis of action

B. O'dowd, S. George, B. Levac, 2001 .

Serotonin transporter gene polymorphisms in alcohol dependence.

D. Comings, B. O'dowd, M. Thompson, 2000, Alcohol.

Minireview: Diversity and complexity of signaling through peptidergic G protein-coupled receptors.

B. O'dowd, A. Rashid, S. George, 2004, Endocrinology.

Distinct Residues in the Carboxyl Tail Mediate Agonist-induced Desensitization and Internalization of the Human Dopamine D1 Receptor*

B. O'dowd, S. George, M. Lamey, 2002, The Journal of Biological Chemistry.

Elimination of palmitoylation sites in the human dopamine D1 receptor does not affect receptor-G protein interaction.

B. O'dowd, S. George, H. Jin, 1997, European journal of pharmacology.

Dopamine D1-D2 Receptor Heteromer-mediated Calcium Release Is Desensitized by D1 Receptor Occupancy with or without Signal Activation

B. O'dowd, S. George, A. Hasbi, 2010, The Journal of Biological Chemistry.

Regulation of Dopamine Receptor Trafficking and Responsiveness

B. O'dowd, S. George, M. Perreault, 2010 .

Regulation of D1 Dopamine Receptor Trafficking and Signaling by Caveolin-1

Susan R. George, B. O'dowd, S. George, 2007, Molecular Pharmacology.

D1 and D2 Dopamine Receptors Form Heterooligomers and Cointernalize after Selective Activation of Either Receptor

B. O'dowd, S. George, Tuan V. Nguyen, 2005, Molecular Pharmacology.

Desensitization, phosphorylation and palmitoylation of the human dopamine D1 receptor.

M. Caron, B. O'dowd, S. George, 1994, European journal of pharmacology.

The Dopamine D1-D2 Receptor Heteromer Localizes in Dynorphin/Enkephalin Neurons

P. Fletcher, P. Seeman, B. O'dowd, 2010, The Journal of Biological Chemistry.

The functional state of the dopamine receptor in the anterior pituitary is in the high affinity form.

P. Seeman, T. Di Paolo, S. George, 1985, Endocrinology.

Oligomerization of Dopamine and Serotonin Receptors

B. O'dowd, S. George, Tuan V. Nguyen, 2000, Neuropsychopharmacology.

THC and CBD blood and brain concentrations following daily administration to adolescent primates.

Sarah L. Withey, M. Huestis, S. George, 2020, Drug and alcohol dependence.

Role for the C-terminus in agonist-induced mu opioid receptor phosphorylation and desensitization.

G. Uhl, B. O'dowd, Y. Yu, 2000, Biochemistry.

A serotonin receptor gene (5HT1A) variant found in a Tourette's syndrome patient.

D. Comings, M. Brann, B. O'dowd, 1996, Biochemical and biophysical research communications.

Effects of daily Δ9-Tetrahydrocannabinol (THC) alone or combined with cannabidiol (CBD) on cognition-based behavior and activity in adolescent nonhuman primates.

S. George, J. Bergman, B. Madras, 2021, Drug and alcohol dependence.

CHAPTER 10 – Expression of G Protein-Coupled Receptors in Baculovirus/Sf9 Cells: Imaging Receptor Distribution by Confocal Fluorescence Microscopy

J. Stevens, B. O'dowd, S. George, 1994 .

Cloning and characterization of additional members of the G protein-coupled receptor family.

H. Heng, P. Seeman, B. O'dowd, 2000, Biochimica et biophysica acta.

The human dopamine D2(Longer) receptor has a high-affinity state and inhibits adenylyl cyclase.

P. Seeman, S. George, I. S. Liu, 2000, Brain research. Molecular brain research.

Homo- and hetero-oligomerization of G protein-coupled receptors.

B. O'dowd, S. George, Susan R George, 2003, Life sciences.

Neuronal Gq/11-coupled dopamine receptors: an uncharted role for dopamine.

B. O'dowd, A. Rashid, S. George, 2007, Trends in pharmacological sciences.

Endocannabinoid System and Exogenous Cannabinoids in Depression and Anxiety: A Review

S. George, B. Madras, A. Hasbi, 2023, Brain sciences.

Calcium Signaling by Dopamine D5 Receptor and D5-D2 Receptor Hetero-Oligomers Occurs by a Mechanism Distinct from That for Dopamine D1-D2 Receptor Hetero-Oligomers

B. O'dowd, A. Rashid, S. George, 2009, Molecular Pharmacology.

Neurochemical evidence supporting dopamine D1–D2 receptor heteromers in the striatum of the long-tailed macaque: changes following dopaminergic manipulation

J. Lanciego, R. Franco, S. George, 2016, Brain Structure and Function.

Agonist-induced functional desensitization of the mu-opioid receptor is mediated by loss of membrane receptors rather than uncoupling from G protein.

B. O'dowd, S. George, M. Scheideler, 1996, Molecular pharmacology.

C. Austin, T. Mcdonald, B. O'dowd, 2001, Biochemical and biophysical research communications.

Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal

D. van der Kooy, S. George, B. Le Foll, 2012, Proceedings of the National Academy of Sciences.

A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.

L. F. Kolakowski, B. O'dowd, S. George, 1997, Biochemical and biophysical research communications.

Genotypic differences in mesolimbic enkephalin gene expression in DBA/2J and C57BL/6J inbred mice.

B. O'dowd, S. George, G. Ng, 1996, European journal of pharmacology.

Corticotropin-releasing factor is altered in brains of animals with high preference for ethanol.

C. Naranjo, S. George, L. Roldan, 1990, Alcoholism, clinical and experimental research.

Regulation of c-fos expression by the dopamine D1-D2 receptor heteromer

S. George, M. Perreault, T. Fan, 2015, Neuroscience.

Serotonin 5‐HT1B and 5‐HT1D receptors form homodimers when expressed alone and heterodimers when co‐expressed

B. O'dowd, S. George, Samuel P. Lee, 1999, FEBS letters.

A Role for the Distal Carboxyl Tails in Generating the Novel Pharmacology and G Protein Activation Profile of μ and δ Opioid Receptor Hetero-oligomers*

Susan R. George, B. O'dowd, S. George, 2005, Journal of Biological Chemistry.

Dopamine D1–D2 Receptor Heteromer in Dual Phenotype GABA/Glutamate-Coexpressing Striatal Medium Spiny Neurons: Regulation of BDNF, GAD67 and VGLUT1/2

B. O'dowd, S. George, M. Perreault, 2012, PloS one.

The µ-δ opioid heteromer masks latent pain sensitization in neuropathic and inflammatory pain in male and female mice

S. George, G. Laumet, K. Inyang, 2021, Brain Research.

Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and ΔFosB

A. Grace, P. Fletcher, B. O'dowd, 2018, Front. Pharmacol..

Characterization of a human gene related to genes encoding somatostatin receptors

L. F. Kolakowski, B. O'dowd, S. George, 1996, FEBS letters.

Dopamine D1 receptors are not critical for opiate reward but can mediate opiate memory retrieval in a state-dependent manner

D. Kooy, S. George, Hector Vargas-Perez, 2013, Behavioural Brain Research.

Dopamine receptor heteromeric complexes and their emerging functions.

R. Franco, S. George, A. Kern, 2014, Progress in brain research.

Mu-opioid receptor heterooligomer formation with the dopamine D1 receptor as directly visualized in living cells.

B. O'dowd, A. Rashid, S. George, 2008, European journal of pharmacology.

The dopamine D1–D2 receptor heteromer exerts a tonic inhibitory effect on the expression of amphetamine-induced locomotor sensitization

S. George, M. Perreault, T. Fan, 2015, Pharmacology Biochemistry and Behavior.

D1 dopamine receptor activity is not altered by a mutation in the first intracellular loop.

B. O'dowd, S. George, H. Jin, 1998, Biochimica et biophysica acta.

Trafficking of preassembled opioid μ-δ heterooligomer-Gz signaling complexes to the plasma membrane: Coregulation by agonists

B. O'dowd, A. Rashid, S. George, 2007 .

Trafficking of preassembled opioid mu-delta heterooligomer-Gz signaling complexes to the plasma membrane: coregulation by agonists.

B. O'dowd, A. Rashid, S. George, 2007, Biochemistry.

A physiological role for the dopamine D5 receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex.

B. O'dowd, S. George, Jace Jones-Tabah, 2013, The international journal of neuropsychopharmacology.

Cloning, characterization, and distribution of a mu-opioid receptor in rat brain.

B. O'dowd, S. George, R. Cheng, 1994, Journal of neurochemistry.

Δ-Tetrahydrocannabinol Increases Dopamine D1-D2 Receptor Heteromer and Elicits Phenotypic Reprogramming in Adult Primate Striatal Neurons

Sarah L. Withey, S. George, J. Bergman, 2019, iScience.

A Novel Dopamine Receptor Signaling Unit in Brain: Heterooligomers of D1 And D2 Dopamine Receptors

B. O'dowd, S. George, 2007, TheScientificWorldJournal.

Disruption of a dopamine receptor complex amplifies the actions of cocaine

P. Fletcher, J. Lanciego, R. Franco, 2016, European Neuropsychopharmacology.

EphB2 reverse signaling regulates learned opiate tolerance via hippocampal function

D. Kooy, S. George, C. Cummins, 2016, Behavioural Brain Research.

Blockade of G Protein-Coupled Receptors and the Dopamine Transporter by a Transmembrane Domain Peptide: Novel Strategy for Functional Inhibition of Membrane Proteins in Vivo

P. Seeman, B. O'dowd, C. Deber, 2003, Journal of Pharmacology and Experimental Therapeutics.

Dopamine inhibition of anterior pituitary adenylate cyclase is mediated through the high-affinity state of the D2 receptor.

S. George, B. Borgundvaag, Susan R. George, 1985, Life sciences.

Dependence of dopamine receptor conversion from agonist high- to low-affinity state on temperature and sodium ions.

P. Seeman, S. George, Masayuki Watanabe, 1985, Biochemical pharmacology.

Cloning, Characterization, and Distribution of a μ‐Opioid Receptor in Rat Brain

B. O'dowd, S. George, Tuan V. Nguyen, 1994 .

Maternal Separation Model of Postpartum Depression: Potential Role for Nucleus Accumbens Dopamine D1–D2 Receptor Heteromer

S. George, A. Hasbi, M. Milenkovic, 2020, Neurochemical Research.

Dopamine Receptor Homooligomers and Heterooligomers in Schizophrenia

B. O'dowd, S. George, M. Perreault, 2011, CNS neuroscience & therapeutics.

A peptide targeting an interaction interface disrupts the dopamine D1‐D2 receptor heteromer to block signaling and function in vitro and in vivo: effective selective antagonism

B. O'dowd, S. George, M. Perreault, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Two gene duplication events in the human and primate dopamine D5 receptor gene family.

H. Niznik, B. O'dowd, S. George, 1995, Gene.

Rapid anti-depressant and anxiolytic actions following dopamine D1–D2 receptor heteromer inactivation

J. Nobrega, S. George, Jace Jones-Tabah, 2015, European Neuropsychopharmacology.

Striatal development involves a switch in gene expression networks, followed by a myelination event: implications for neuropsychiatric disease

B. O'dowd, S. George, T. Fan, 2013 .

Sex difference in dopamine D1-D2 receptor complex expression and signaling affects depression- and anxiety-like behaviors

R. Tyndale, S. George, S. Miksys, 2020, Biology of Sex Differences.

Resistance of the dopamine D2L receptor to desensitization accompanies the up-regulation of receptors on to the surface of Sf9 cells.

P. Seeman, B. O'dowd, S. George, 1997, Endocrinology.

The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain.

H. Heng, L. Tsui, B. O'dowd, 1995, Genomics.

Sex difference in dopamine D1-D2 receptor complex expression and signaling affects depression- and anxiety-like behaviors

R. Tyndale, S. George, S. Miksys, 2020, Biology of Sex Differences.

Functional States of Dopamine Receptors

P. Seeman, S. George, D. Grigoriadis, 1986 .

Daily THC and withdrawal increase dopamine D1-D2 receptor heteromer to mediate anhedonia and anxiogenic-like behavior through a dynorphin and kappa opioid receptor mechanism

S. George, B. Madras, A. Hasbi, 2022 .

Disruption of a dopamine receptor complex amplifies the actions of cocaine

P. Fletcher, J. Lanciego, R. Franco, 2016, European Neuropsychopharmacology.

Striatal development involves a switch in gene expression networks, followed by a myelination event: Implications for neuropsychiatric disease

B. O'dowd, S. George, G. Novak, 2013, Synapse.

Oligomerization of m- and d-Opioid Receptors

B. O'dowd, S. George, G. Varghese, 2000 .

Calcium Signaling by Dopamine D5-D2 Receptor Heterooligomers Occurs by a Mechanism Distinct From That For Dopamine D1-D2 Receptor Heterooligomers

B. O'dowd, S. George, R. Cheng, 2009 .

A G protein-coupled receptor for estrogen: the end of the search?

B. O'dowd, S. George, A. Hasbi, 2005, Molecular interventions.