J. Ashwell

发表

Allogeneic non-T spleen cells restore the responsiveness of normal T cell clones stimulated with antigen and chemically modified antigen-presenting cells.

R. Schwartz, M. Jenkins, J. Ashwell, 1988, Journal of immunology.

Sequential involvement of NFAT and Egr transcription factors in FasL regulation.

L. Glimcher, J. Ashwell, J. Rengarajan, 2000, Immunity.

Cyclosporin A-Sensitive Transcription Factor Egr-3 Regulates Fas Ligand Expression

J. Ashwell, P. Mittelstadt, Jonathan D. Ashwell, 1998, Molecular and Cellular Biology.

Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation.

J. Ashwell, U. D'Oro, M. Vacchio, 1997, Immunity.

TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

Yili Yang, J. Ashwell, Xiaoming Li, 2002, Nature.

Glucocorticoids in T cell development and function*.

J. Ashwell, M. Vacchio, F. Lu, 2000, Annual review of immunology.

Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP.

Yongge Zhao, J. Ashwell, Guozhi Zhu, 2007, Current biology : CB.

Steroid production in the thymus: implications for thymocyte selection

V. Papadopoulos, J. Ashwell, M. Vacchio, 1994, The Journal of experimental medicine.

Recruitment of A20 by the C-terminal domain of NEMO suppresses NF-κB activation and autoinflammatory disease

J. Orange, R. Siegel, J. Ashwell, 2016, Proceedings of the National Academy of Sciences.

A20: more than one way to skin a cat.

S. Srinivasula, J. Ashwell, 2011, Molecular cell.

CYLD and the NEMO Zinc Finger Regulate Tumor Necrosis Factor Signaling and Early Embryogenesis*

Liming Wu, Chi A. Ma, Yongge Zhao, 2015, The Journal of Biological Chemistry.

TNF‐α induced c‐IAP1/TRAF2 complex translocation to a Ubc6‐containing compartment and TRAF2 ubiquitination

J. Ashwell, J. Hanover, Xiaoming Li, 2005, The EMBO journal.

Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression

Frank Bergmann, Serguei V. Kozlov, T. Giese, 2015, Nature Medicine.

Non-Canonical NF-κB Activation and Abnormal B Cell Accumulation in Mice Expressing Ubiquitin Protein Ligase-Inactive c-IAP2

Yongge Zhao, J. Ashwell, D. Conze, 2010, PLoS biology.

TWEAKing death

J. Ashwell, 2008, The Journal of cell biology.

Tumor Necrosis Factor Receptor 2 Signaling Induces Selective c-IAP1-dependent ASK1 Ubiquitination and Terminates Mitogen-activated Protein Kinase Signaling*

Yongge Zhao, J. Ashwell, J. Hanover, 2007, Journal of Biological Chemistry.

Posttranscriptional Downregulation of c-IAP2 by the Ubiquitin Protein Ligase c-IAP1 In Vivo

D. Goeddel, T. Mak, W. Yeh, 2005, Molecular and Cellular Biology.

Suppression of Dendritic Cell-Derived IL-12 by Endogenous Glucocorticoids Is Protective in LPS-Induced Sepsis

J. Ashwell, I. Munitic, P. Mittelstadt, 2015, PLoS biology.

Programmed T lymphocyte death. Cell activation- and steroid-induced pathways are mutually antagonistic.

M. Merćep, J. Ashwell, S. Simons, 1990, Journal of immunology.

T Cell Receptor-mediated Activation of p38α by Mono-phosphorylation of the Activation Loop Results in Altered Substrate Specificity*

E. Appella, H. Yamaguchi, J. Ashwell, 2009, The Journal of Biological Chemistry.

Mutational analysis of Lck in CD45-negative T cells: dominant role of tyrosine 394 phosphorylation in kinase activity

K. Sakaguchi, E. Appella, J. Ashwell, 1996, Molecular and cellular biology.

The TBK1‐binding domain of optineurin promotes type I interferon responses

J. Ashwell, I. Munitic, P. Mittelstadt, 2016, FEBS letters.

Optineurin Insufficiency Impairs IRF3 but Not NF-κB Activation in Immune Cells

J. Ashwell, I. Munitic, Guozhi Zhu, 2013, The Journal of Immunology.

Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-κB activation

S. Srinivasula, J. Ashwell, Chuan-Jin Wu, 2006, Nature Cell Biology.

Ubiquitin binding mediates the NF-κB inhibitory potential of ABIN proteins

V. Dötsch, I. Dikic, J. Ashwell, 2008, Oncogene.

Regulation of TCR signaling by CD45 lacking transmembrane and extracellular domains.

C. June, S. Volarevic, J. Ashwell, 1993, Science.

T cell CD3-zeta eta heterodimer expression and coupling to phosphoinositide hydrolysis.

J. Bonifacino, R. Klausner, M. Merćep, 1988, Science.

Dissociation of phosphoinositide hydrolysis and Ca2+ fluxes from the biological responses of a T-cell hybridoma

R. Germain, M. Merćep, J. Ashwell, 1988, Nature.

Intensity and duration of TCR signaling is limited by p38 phosphorylation of ZAP-70T293 and destabilization of the signalosome

E. Appella, V. Barr, J. Ashwell, 2018, Proceedings of the National Academy of Sciences.

Role of the zeta chain in the expression of the T cell antigen receptor: genetic reconstitution studies.

R. Klausner, D. Orloff, M. Merćep, 1989, The EMBO journal.

Host-Derived CD70 Suppresses Murine Graft-versus-Host Disease by Limiting Donor T Cell Expansion and Effector Function

J. Ashwell, Jingxin Qiu, P. McCarthy, 2017, The Journal of Immunology.

Inhibition of AP-1 by the Glucocorticoid-inducible Protein GILZ*

J. Ashwell, P. Mittelstadt, 2001, The Journal of Biological Chemistry.

Recruitment of calcineurin to the TCR positively regulates T cell activation

V. Barr, J. Ashwell, L. Samelson, 2016, Nature Immunology.

c-IAP1 and c-IAP2 Redundancy Differs between T and B Cells

J. Ashwell, D. Conze, M. L. Giardino Torchia, 2013, PloS one.

c‐IAP ubiquitin protein ligase activity is required for 4‐1BB signaling and CD8+ memory T‐cell survival

Jasmin Herz, J. Ashwell, I. Munitic, 2015, European journal of immunology.

Cutting edge: the CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes.

J. Ashwell, U. D'Oro, 1999, Journal of immunology.

NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-κB activation

J. Ashwell, Chuan-Jin Wu, 2008, Proceedings of the National Academy of Sciences.

Thymocyte responsiveness to endogenous glucocorticoids is required for immunological fitness.

J. Ashwell, P. Mittelstadt, J. P. Monteiro, 2012, The Journal of clinical investigation.

GLUCOCORTICOIDS IN TC ELL DEVELOPMENT AND FUNCTION

J. Ashwell, M. Vacchio, F. Lu, 2000 .

Promotion and Inhibition of Activation‐Induced Apoptosis in T‐Cell Hybridomas by Oncogenes and Related Signals

D. Green, Yili Yang, J. Ashwell, 1994, Immunological reviews.

Response to Secondary Stimulation Provide a Memory-Like 1 T Cells in

J. Ashwell, I. Munitic, Philip E. Ryan, 2005 .

Disruption of glucocorticoid receptor exon 2 yields a ligand-responsive C-terminal fragment that regulates gene expression.

J. Ashwell, P. Mittelstadt, 2003, Molecular endocrinology.

Glucocorticoids and thymocyte development.

J. Ashwell, M. Vacchio, 2000, Seminars in immunology.

Glucocorticoid-inducible genes that regulate T-cell function.

D. Franchimont, J. Galon, J. O’Shea, 2002, Ernst Schering Research Foundation workshop.

Lymphocytic Choriomeningitis Virus Dispensable for the Recall Response to Cell Generation and Viral Clearance but Is CD70 Deficiency Impairs Effector CD8 T

J. Ashwell, I. Munitic, M. Kuka, 2013 .

CD70 Deficiency Impairs Effector CD8 T Cell Generation and Viral Clearance but Is Dispensable for the Recall Response to Lymphocytic Choriomeningitis Virus

J. Ashwell, I. Munitic, M. Kuka, 2013, The Journal of Immunology.

T Cells in G1 Provide a Memory-Like Response to Secondary Stimulation

J. Ashwell, I. Munitic, Philip E. Ryan, 2005, The Journal of Immunology.

The CD45 tyrosine phosphatase regulates phosphotyrosine homeostasis and its loss reveals a novel pattern of late T cell receptor-induced Ca2+ oscillations

C. June, S. Volarevic, J. Ashwell, 1992, The Journal of experimental medicine.

Scavenger Receptor BI and High-Density Lipoprotein Regulate Thymocyte Apoptosis in Sepsis

A. Remaley, J. Ashwell, P. Mittelstadt, 2014, Arteriosclerosis, thrombosis, and vascular biology.

SR-BI Controls Inducible Glucocorticoid Generation in Response to Septic Stress , Which Is a Determinant of Thymocyte Apoptosis in Sepsis

A. Remaley, J. Ashwell, P. Mittelstadt, 2022 .

Role of Egr-2 in Up-regulation of Fas Ligand in Normal T Cells and Aberrant Double-negative lpr and gld T Cells*

J. Ashwell, P. Mittelstadt, 1999, The Journal of Biological Chemistry.

CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases.

K. Sakaguchi, E. Appella, J. Ashwell, 1994, The Journal of biological chemistry.

Thymocyte glucocorticoid resistance alters positive selection and inhibits autoimmunity and lymphoproliferative disease in MRL-lpr/lpr mice.

J. Ashwell, E. Tolosa, L. King, 1998, Immunity.

A cysteine protease inhibitor prevents activation-induced T-cell apoptosis and death of peripheral blood cells from human immunodeficiency virus-infected individuals by inhibiting upregulation of Fas ligand.

C. Ware, J. Ashwell, Y. Yang, 1997, Blood.

Antigen presentation by resting B cells. Radiosensitivity of the antigen-presentation function and two distinct pathways of T cell activation

W. Paul, R. Schwartz, J. Ashwell, 1984, The Journal of experimental medicine.

"Exon-shuffling" maps control of antibody- and T-cell-recognition sites to the NH2-terminal domain of the class II major histocompatibility polypeptide A beta.

R. Germain, D. Margulies, R. Lechler, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis.

Yili Yang, J. Ashwell, I. Munitic, 2004, Blood.

Mutually antagonistic signals regulate selection of the T cell repertoire.

J. Ashwell, L. Ignatowicz, G. Stephens, 2003, International immunology.

Activation Inhibiting TCR-Mediated Thymocyte Thresholds for Thymocyte Selection by Thymus-Derived Glucocorticoids Set the

J. Ashwell, M. Vacchio, Jan Lee, 1999 .

Thymus-derived Glucocorticoids Regulate Antigen-specific Positive Selection

J. Ashwell, M. Vacchio, 1997, The Journal of experimental medicine.

A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development.

D. Margulies, J. Ashwell, M. Vacchio, 1995, Immunity.

9-cis-retinoic acid inhibits activation-driven T-cell apoptosis: implications for retinoid X receptor involvement in thymocyte development.

J. Ashwell, Y. Yang, M. Vacchio, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Identification and characterization of polyclonal αβ T cells with dendritic cell properties

J. Ashwell, I. Munitic, M. Kuka, 2012, Nature Communications.

Genetic disruption of p38alpha Tyr323 phosphorylation prevents T-cell receptor-mediated p38alpha activation and impairs interferon-gamma production.

J. Ashwell, P. Mittelstadt, D. Jankovic, 2009, Blood.

Genetic disruption of p38 (cid:1) Tyr323 phosphorylation prevents T-cell receptor–mediated p38 (cid:1) activation and impairs interferon- (cid:2) production

J. Ashwell, P. Mittelstadt, Dragana Jankovic, 2009 .

An inducible lymphocyte nuclear Ca2+/Mg(2+)-dependent endonuclease associated with apoptosis.

N. Khodarev, J. Ashwell, 1996, Journal of immunology.

Signaling for death of lymphoid cells.

J. Ashwell, L. King, 1993, Current opinion in immunology.

CD4+ T cells are trigger and target of the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection

A. Sher, J. Ashwell, P. Mittelstadt, 2013, The Journal of experimental medicine.

Interleukin 2 upregulates expression of its receptor on a T cell clone

J. Ashwell, T. Malek, Thomas R. Malek, 1985, The Journal of experimental medicine.

Calcineurin inhibitors suppress acute graft-vs-host disease via NFAT-independent inhibition of T cell receptor signaling.

J. Ashwell, N. Melis, R. Weigert, 2021, The Journal of clinical investigation.

Lys63-Linked Polyubiquitination of IRAK-1 Is Required for Interleukin-1 Receptor- and Toll-Like Receptor-Mediated NF- (cid:2) B Activation (cid:1) †

J. Ashwell, James A. Thomas, Chuan-Jin Wu, 2008 .

The CD8+ memory T-cell state of readiness is actively maintained and reversible.

J. Ashwell, I. Munitic, H. Yagita, 2009, Blood.

Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids

C. Ware, Yili Yang, M. Merćep, 1995, The Journal of experimental medicine.

Wip 1 Phosphatase-Deficient Mice Exhibit Defective T Cell Maturation Due To Sustained p 53 Activation 1

E. Appella, O. Demidov, J. Ashwell, 2006 .

The Murine Interleukin‐2 Receptor: Biochemical Structure and Regulation of Expression

R. Germain, E. Shevach, J. Ashwell, 1986, Immunological reviews.

Regulation of the p70zap tyrosine protein kinase in T cells by the CD45 phosphotyrosine phosphatase

T. Mustelin, J. Ashwell, A. Altman, 1995, European journal of immunology.

T-cell recognition of antigen and the Ia molecule as a ternary complex

R. Schwartz, J. Ashwell, 1986, Nature.

Effects of sex steroids on thymic epithelium and thymocyte development

J. Ashwell, M. Taves, 2022, Frontiers in Immunology.

Glucocorticoids Oppose Thymocyte Negative Selection by Inhibiting Helios and Nur77

J. Ashwell, P. Mittelstadt, M. Taves, 2019, The Journal of Immunology.

Phosphoinositide 3-Kinase Regulation of T Cell Receptor-mediated Interleukin-2 Gene Expression in Normal T Cells*

T. Franke, J. Ashwell, A. Eder, 1998, The Journal of Biological Chemistry.

Activator of Adaptive Responses Modulator of Early Cytokine Responses and Dual Function of Cd70 in Viral Infection: Dual Function of Cd70 in Viral Infection: Modulator of Early Cytokine Responses and Activator of Adaptive Responses

M. Colonna, J. Ashwell, W. Vermi, 2022 .

This information is current as Activator of Adaptive Responses Modulator of Early Cytokine Responses and Dual Function of CD 70 in Viral Infection : Ashwell and

M. Colonna, J. Ashwell, W. Vermi, 2014 .

Ionizing Radiation Impairs T Cell Activation by Affecting Metabolic Reprogramming

A. Fornace, Heng-Hong Li, Renxiang Chen, 2015, International journal of biological sciences.

Thy-1- and Ly-6-mediated lymphokine production and growth inhibition of a T cell hybridoma require co-expression of the T cell antigen receptor complex.

R. Germain, E. Shevach, J. Ashwell, 1988, Journal of immunology.

Cell growth cycle block of T cell hybridomas upon activation with antigen

R. E. Cunningham, J. Ashwell, P. Noguchi, 1987, The Journal of experimental medicine.

Use of bispecific heteroconjugated antibodies (anti-T cell antigen receptor x anti-MHC class II) to study activation of T cells with a full length or truncated antigen receptor zeta-chain.

J. Ashwell, S. Sadegh-Nasseri, Y. Yang, 1993, Journal of immunology.

24 – T Cell Recognition of Antigen and Ia Molecules Involves a Trimolecular Complex

R. Schwartz, J. Ashwell, B. Fox, 1988 .

CD45 tyrosine phosphatase activity and membrane anchoring are required for T-cell antigen receptor signaling.

C. June, J. Ashwell, A. M. Weissman, 1994, Molecular and cellular biology.

ZAPping the T-cell receptor

J. Ashwell, C. Burns, 1993, Current Biology.

Chapter 3 – Lymphocyte Programmed Cell Death

J. Ashwell, 1994 .

Expression of v-src in a murine T-cell hybridoma results in constitutive T-cell receptor phosphorylation and interleukin 2 production.

S. L. Cross, R. Klausner, J. O’Shea, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Activation-driven programmed cell death and T cell receptor zeta eta expression.

R. Klausner, A. Weissman, M. Merćep, 1989, Science.

Inhibition of transformed T cell growth in vitro by monoclonal antibodies directed against distinct activating molecules.

J. Bluestone, M. Merćep, J. Ashwell, 1988, Journal of immunology.

Activation-driven T cell death. I. Requirements for de novo transcription and translation and association with genome fragmentation.

J. Ashwell, D. Ucker, G. Nickas, 1989, Journal of immunology.

The cell cycle block and lysis of an activated T cell hybridoma are distinct processes with different Ca2+ requirements and sensitivity to cyclosporine A.

M. Merćep, J. Ashwell, P. Noguchi, 1989, Journal of immunology.

Cutting edge: the CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes.

J. Ashwell, U. D'Oro, U. D’Oro, 1999, Journal of immunology.

Polyclonal stimulation of resting B lymphocytes by antigen-specific T lymphocytes

W. Paul, R. Schwartz, J. Ashwell, 1984, The Journal of experimental medicine.

Lack of the T cell-specific alternative p38 activation pathway reduces autoimmunity and inflammation.

J. Ashwell, P. Mittelstadt, Nandakumara D. Sarma, 2011, Blood.

T cell priming: let there be light

J. Ashwell, L. Jirmanova, 2010, Cell Research.

HIV Tat Binds Egr Proteins and Enhances Egr-dependent Transactivation of the Fas Ligand Promoter*

Yili Yang, J. Ashwell, P. Mittelstadt, 2002, The Journal of Biological Chemistry.

Are B lymphocytes the principal antigen-presenting cells in vivo?

J. Ashwell, 1988, Journal of immunology.

Susceptibility to cell death is a dominant phenotype: triggering of activation-driven T-cell death independent of the T-cell antigen receptor complex

J. Ashwell, D. Gold, Beate C. Sydora, 1992, Molecular and cellular biology.

Mutagenesis of T cell antigen receptor zeta chain tyrosine residues. Effects on tyrosine phosphorylation and lymphokine production.

J. Ashwell, S. Frank, A. M. Weissman, 1992, The Journal of biological chemistry.

Coming to terms with death: apoptosis in cancer and immune development.

S. Korsmeyer, D. Lane, J. Cidlowski, 1994, Immunology today (Amsterdam. Regular ed.).

The tyrosine phosphatase activity of the CD45 cell-surface molecule may have a vital role in the function of the T cell antigen receptor.

J. Ashwell, 1991 .

Dominant negative mutant of c-Jun inhibits NF-AT transcriptional activity and prevents IL-2 gene transcription.

M. Birrer, J. Ashwell, D. Petrak, 1994, Journal of immunology.

Proliferation of T lymphocytes in response to interleukin 2 varies with their state of activation.

J. Ashwell, T. Malek, R. Robb, 1986, Journal of Immunology.

Functional analysis of the interaction of the antigen-specific T cell receptor with its ligands.

R. Schwartz, J. Ashwell, B. Fox, 1986, Journal of immunology.

Constitutive expression of interferon gamma-inducible protein 10 in lymphoid organs and inducible expression in T cells and thymocytes

J. Ashwell, A. Luster, C. Gattass, 1994, The Journal of experimental medicine.

T-cell tumor elimination as a result of T-cell receptor-mediated activation.

D. Longo, J. Ashwell, S. Bridges, 1987, Science.

Antigen presentation by resting B cells. Effectiveness at inducing T cell proliferation is determined by costimulatory signals, not T cell receptor occupancy.

M. Jenkins, J. Ashwell, E. Burrell, 1990, Journal of immunology.

Tyrosine kinase-regulated and inositol phosphate-independent Ca2+ elevation and mobilization in T cells.

C. June, J. O’Shea, J. Ashwell, 1992, The Journal of biological chemistry.

Structural mutations of the T cell receptor zeta chain and its role in T cell activation.

R. Klausner, D. Orloff, M. Merćep, 1990, Science.

CYLD and NEMO regulate TNF signaling

Liming Wu, Chi A. Ma, Yongge Zhao, 2015 .

Marked differences in the efficiency of expression of distinct alpha beta T cell receptor heterodimers.

R. Germain, J. Sussman, J. Ashwell, 1989, Journal of immunology.

Regulation of Constitutive TCR Internalization by the ζ-Chain

T. Karpova, J. Ashwell, I. Munitic, 2002, The Journal of Immunology.

CD70 Is Downregulated by Interaction with CD27

J. Ashwell, M. Kuka, Ivana Munitic, 2013, The Journal of Immunology.

CD27CD70 Is Downregulated by Interaction with

J. Ashwell, M. Kuka, M. Torchia, 2013 .

Mutagenesis of T Cell Antigen Receptor { Chain Tyrosine Residues

J. Ashwell, S. Frank, Cristina Cenciarelliq, 2001 .

A Positive Role for Thymus‐Derived Steroids in Formation of the T‐Cell Repertoire

J. Ashwell, M. Vacchio, L. King, 1998, Annals of the New York Academy of Sciences.

Thymus-Derived Glucocorticoids and the Regulation of Antigen-Specific T-Cell Development

J. Ashwell, E. Tolosa, 1999, Neuroimmunomodulation.

T cell activation and increases in protein kinase C activity enhance retinoic acid-induced gene transcription.

S. Minucci, K. Ozato, J. Ashwell, 1994, Molecular endocrinology.

Intimate association of Thy-1 and the T-cell antigen receptor with the CD45 tyrosine phosphatase.

S. Volarevic, J. Ashwell, C. Burns, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis

J. Ashwell, A. Eder, L. King, 1997, Molecular and cellular biology.

Glucocorticoids in T cell development, differentiation and function

J. Ashwell, M. Taves, 2020, Nature Reviews Immunology.

Efficient Inhibition of Activation-induced Fas Ligand Up-regulation and T Cell Apoptosis by Retinoids Requires Occupancy of both Retinoid X Receptors and Retinoic Acid Receptors (*)

S. Minucci, Yili Yang, K. Ozato, 1995, The Journal of Biological Chemistry.

Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected].

S. Srinivasula, J. Ashwell, Chuan-Jin Wu, 2006, Nature cell biology.

Thymocyte Apoptosis

Yili Yang, J. Ashwell, 2004, Journal of Clinical Immunology.

Outer membrane vesicles of a human commensal mediate immune regulation and disease protection.

S. Mazmanian, J. Ashwell, C. Karp, 2012, Cell host & microbe.

An overview of mammalian p38 mitogen-activated protein

J. Ashwell, 2020 .

Bacterial death induced by expression of the intracellular portion of human Fas

Yili Yang, J. Ashwell, A. Eder, 1999, Cell Death and Differentiation.

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli.

Yili Yang, S. Fang, J. P. Jensen, 2000, Science.

IAPs: what's in a name?

S. Srinivasula, J. Ashwell, 2008, Molecular cell.

Model cell lines for the study of apoptosis in vitro.

L. Schwartz, B. Osborne, S. Chouaib, 2001, Methods in cell biology.

Structural basis for recognition of diubiquitins by NEMO.

Hao Wu, Yu-Chih Lo, Su-Chang Lin, 2009, Molecular cell.

Activating p38 MAPK: New Tricks for an Old Kinase

J. Ashwell, P. Mittelstadt, J. M. Salvador, 2005, Cell cycle.

Fruitful outcomes of intracellular cross-talk

J. Ashwell, C. Zacharchuk, 1992, Current Biology.

Failure to synthesize the T Cell CD3-ζ chain: Structure and function of a partial T cell receptor complex

J. Lippincott-Schwartz, J. Bonifacino, R. Klausner, 1988, Cell.

Genetic and mutational analysis of the T-cell antigen receptor.

J. Ashwell, J D Ashwell, R D Klusner, 1990, Annual review of immunology.

Genomic instability in Gadd45a-deficient mice

William F. Morgan, Eva Tolosa, Qimin Zhan, 1999, Nature Genetics.

Getting MAD at MYC

J. Ashwell, Maria Letizia Giardino Torchia, 2018, Proceedings of the National Academy of Sciences.

Wip1 Phosphatase-Deficient Mice Exhibit Defective T Cell Maturation Due To Sustained p53 Activation1

E. Appella, O. Demidov, J. Ashwell, 2006, The Journal of Immunology.

Cross‐Talk between the T Cell Antigen Receptor and the Glucocorticoid Receptor Regulates Thymocyte Development

J. Ashwell, M. Vacchio, L. King, 1996, Stem cells.

Regulation of constitutive TCR internalization by the zeta-chain.

T. Karpova, J. Ashwell, James G. McNally, 2002, Journal of immunology.

Single-Cell Resolution and Quantitation of Targeted Glucocorticoid Delivery in the Thymus.

G. Hager, Diego M. Presman, J. Ashwell, 2019, Cell reports.

Retinoic acid inhibition of ex vivo human immunodeficiency virus-associated apoptosis of peripheral blood cells.

J. Ashwell, Y. Yang, M. Vacchio, 1995, Proceedings of the National Academy of Sciences of the United States of America.

The many paths to p38 mitogen-activated protein kinase activation in the immune system

J. Ashwell, 2006, Nature Reviews Immunology.

Cutting Edge: De Novo Glucocorticoid Synthesis by Thymic Epithelial Cells Regulates Antigen-Specific Thymocyte Selection

J. Ashwell, P. Mittelstadt, M. Taves, 2018, The Journal of Immunology.

Alternative p38 activation pathway mediated by T cell receptor–proximal tyrosine kinases

E. Appella, A. Fornace, H. Yamaguchi, 2005, Nature Immunology.

Effect of gamma radiation on resting B lymphocytes. II. Functional characterization of the antigen-presentation defect.

R. Schwartz, M. Jenkins, J. Ashwell, 1988, Journal of immunology.

Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome.

A. Fornace, M. C. Hollander, J. Ashwell, 2002, Immunity.

DifferentiationCytokine Production and Th1 Regulates p38-Dependent Dendritic α Gadd45

J. Ashwell, Dragana Jankovic, L. Jirmanova, 2013 .

Gadd45α Regulates p38-Dependent Dendritic Cell Cytokine Production and Th1 Differentiation1

A. Fornace, J. Ashwell, Dragana Jankovic, 2007, The Journal of Immunology.

The autoimmune suppressor Gadd45α inhibits the T cell alternative p38 activation pathway

A. Fornace, J. Ashwell, G. I. Belova, 2005, Nature Immunology.

High frequency and nonrandom distribution of alloreactivity in T cell clones selected for recognition of foreign antigen in association with self class II molecules.

R. Schwartz, J. Ashwell, C. Chen, 1986, Journal of immunology.

A dominant-negative mutant of c-Jun inhibits cell cycle progression during the transition of CD4(-)CD8(-) to CD4(+)CD8(+) thymocytes.

J. Ashwell, H. Petrie, F. Lu, 1999, International immunology.

Thymocyte resistance to glucocorticoids leads to antigen-specific unresponsiveness due to "holes" in the T cell repertoire.

R. Germain, J. Ashwell, F. Lu, 2000, Immunity.

Systemic toxoplasma infection triggers a long-term defect in the generation and function of naive T lymphocytes

A. Sher, O. Kamenyeva, J. Ashwell, 2016, The Journal of experimental medicine.

TNF plays a crucial role in inflammation by signaling via T cell TNFR2

D. Meerzaman, J. Ashwell, M. Gaida, 2021, Proceedings of the National Academy of Sciences.

Positive Effects of Glucocorticoids on T Cell Function by Up-Regulation of IL-7 Receptor α1

D. Franchimont, G. Chrousos, J. Galon, 2002, The Journal of Immunology.

Counter-regulation of T cell effector function by differentially activated p38

F. Lasitschka, J. Ashwell, M. Gaida, 2014, The Journal of experimental medicine.

Anti-CD3 monoclonal antibody treatment of patients with CD3-negative tumors: a phase IA/B study.

M. Sznol, W. Urba, J. Ashwell, 1992, Cancer research.

Thymocyte Activation and Death: a Mechanism for Molding the T Cell Repertoire

M. Merćep, J. Ashwell, C. Zacharchuk, 1991, Annals of the New York Academy of Sciences.

Antigen-driven T cell expansion: affinity rules.

J. Ashwell, 2004, Immunity.

Thymus-derived glucocorticoids set the thresholds for thymocyte selection by inhibiting TCR-mediated thymocyte activation.

J. Ashwell, M. Vacchio, J. Y. Lee, 1999, Journal of immunology.

Exploiting the apoptotic process for management of HIV: Are we there yet?

J. Ashwell, Y. Yang, 2001, Apoptosis.

Lys63-Linked Polyubiquitination of IRAK-1 Is Required for Interleukin-1 Receptor- and Toll-Like Receptor-Mediated NF-κB Activation

J. Ashwell, James A. Thomas, Chuan-Jin Wu, 2008, Molecular and Cellular Biology.

Discovery and Characterization of a Biologically Active Non–ATP-Competitive p38 MAP Kinase Inhibitor

Jason R. Evans, P. Wipf, E. Goncharova, 2016, Journal of biomolecular screening.

Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation

E. Appella, J. Ashwell, M. Gaida, 2018, PLoS biology.

Subunit interactions within the T-cell antigen receptor: clues from the study of partial complexes.

J. Lippincott-Schwartz, J. Bonifacino, R. Klausner, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Using Chromatin-Nuclear Receptor Interactions to Quantitate Endocrine, Paracrine, and Autocrine Signaling

J. Ashwell, M. Taves, 2020, Nuclear receptor signaling.

Live Cell Imaging Unveils Multiple Domain Requirements for In Vivo Dimerization of the Glucocorticoid Receptor

L. Grøntved, G. Hager, Thomas A. Johnson, 2014, PLoS biology.

CD45 and Src-family kinases: and now for something completely different.

J. Ashwell, U. D’Oro, 1999, Immunology today.

Optineurin Negatively Regulates TNFα- Induced NF-κB Activation by Competing with NEMO for Ubiquitinated RIP

Yongge Zhao, J. Ashwell, Guozhi Zhu, 2007, Current Biology.

Thymocyte and T cell apoptosis: is all death created equal?

J. Ashwell, L. King, 1994, Thymus.

When complex worlds collide: retinoic acid and apoptosis

J. Ashwell, 1998, Cell Death and Differentiation.

Effect of gamma radiation on resting B lymphocytes. I. Oxygen-dependent damage to the plasma membrane results in increased permeability and cell enlargement.

R. Schwartz, J. Ashwell, J. Mitchell, 1986, Journal of immunology.

Balance between NF-κB p100 and p52 Regulates T Cell Costimulation Dependence

J. Ashwell, Dragana Jankovic, D. Conze, 2013, The Journal of Immunology.

ThymocytesPhosphatase Is an Inhibitor of Lck Activity in Cutting Edge: The CD45 Tyrosine

J. Ashwell, U. D’Oro, 1999 .

Do glucocorticoids participate in thymocyte development?

J. Galon, J. Ashwell, M. Vacchio, 2000, Immunology today.

To be or not to be: mutually antagonistic death signals regulate thymocyte apoptosis.

J. Ashwell, M. Vacchio, L. King, 1994, International archives of allergy and immunology.

Nuclear Receptors and Thymocyte Apoptosis: Shaping the Immune Repertoire

Yili Yang, J. Ashwell, M. Vacchio, 1994 .

Role of Ly-6A/E and T cell receptor-zeta for IL-2 production. Phosphatidylinositol-anchored Ly-6A/E antagonizes T cell receptor-mediated IL-2 production by a zeta-independent pathway.

J. Ashwell, T. Malek, C. Zacharchuk, 1992, Journal of immunology.

Aire drives steroid hormone biosynthesis by medullary thymic epithelial cells

M. Cam, J. Ashwell, M. Taves, 2023, Science Immunology.

Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4+ T cells

J. Ashwell, Kyung S. Lee, F. Maldarelli, 2023, Research square.

The CD45 tyrosine phosphatase regulates phosphotyrosine homeostasis and its loss reveals a novel pattern of late T cell receptor-induced Ca2+ oscillations

C. June, S. Volarevic, J. Ashwell, 1992, The Journal of experimental medicine.

Failure to synthesize the T cell CD3-zeta chain: structure and function of a partial T cell receptor complex.

J. Bonifacino, J. Ashwell, A. M. Weissman, 1988, Cell.

Tumors produce glucocorticoids by metabolite recycling, not synthesis, and activate Tregs to promote growth

M. Cam, J. Ashwell, M. Taves, 2023, The Journal of clinical investigation.

A method for high purity sorting of rare cell subsets applied to TDC.

J. Ashwell, M. Kuka, 2013, Journal of immunological methods.

Structural basis for recognition of diubiquitins by NEMO.

J. Ashwell, Chuan-Jin Wu, D. Conze, 2009, Molecular cell.

Constitutive Expression of Interferon Y-inducible Protein 10 in Lymphoid Organs and Inducible Expression in T Cells and Thymocytes

J. Ashwell, C. Gattass, Andy D. Luster, 1994 .

ThymocytesPhosphatase Is an Inhibitor of Lck Activity in Cutting Edge: The CD45 Tyrosine

J. Ashwell, U. D’Oro, 1999 .

Lymphocytic Choriomeningitis Virus Dispensable for the Recall Response to Cell Generation and Viral Clearance but Is Cd70 Deficiency Impairs Effector Cd8 T

J. Ashwell, M. Kuka, Atef A. Allam, 2022 .

Selective Inhibition of the P38 Alternative Activation Pathway in Infiltrating T Cells Inhibits Pancreatic Cancer Progression Hhs Public Access

J. Ashwell, Muhammad S. Alam, MatthiasM. Gaida, 2022 .

Lack of the T cell-specific alternative p38 activation pathway reduces autoimmunity and inflammation.

J. Ashwell, P. Mittelstadt, Nandakumara D. Sarma, 2011, Blood.

Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis.

Yili Yang, J. Ashwell, R. Gress, 2004, Blood.

Variations in thymocyte susceptibility to clonal deletion during ontogeny. Implications for neonatal tolerance.

M. Merćep, J. Ashwell, Allan M. Weissman, 1991, Journal of immunology.

Dual Function of CD70 in Viral Infection: Modulator of Early Cytokine Responses and Activator of Adaptive Responses

M. Colonna, J. Ashwell, W. Vermi, 2014, The Journal of Immunology.