H. Waldmann

H. Waldmann, S. Cobbold, S. Daley, 2008, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Regulatory T Cells Promote Apelin-Mediated Sprouting Angiogenesis in Type 2 Diabetes.

Kathy O. Lui, Bin Zhou, Manching Ku, 2018, Cell reports.

Successful attenuation of humoral immunity to viral capsid and transgenic protein following AAV-mediated gene transfer with a non-depleting CD4 antibody and cyclosporine

A. Davidoff, H. Waldmann, S. Cobbold, 2011, Gene Therapy.

Tolerance to rat monoclonal antibodies. Implications for serotherapy

H. Waldmann, S. Cobbold, M. Clark, 1986, The Journal of experimental medicine.

Human monoclonal IgG isotypes differ in complement activating function at the level of C4 as well as C1q

M. Brüggemann, G. Hale, H. Waldmann, 1988, The Journal of experimental medicine.

A matched set of rat/mouse chimeric antibodies. Identification and biological properties of rat H chain constant regions mu, gamma 1, gamma 2a, gamma 2b, gamma 2c, epsilon, and alpha.

M. Brüggemann, H. Waldmann, M. Clark, 1989, Journal of immunology.

A humanized monovalent CD3 antibody which can activate homologous complement

S. D. Gorman, H. Waldmann, M. Clark, 1991, European journal of immunology.

The generation of a humanized, non‐mitogenic CD3 monoclonal antibody which retains in vitro immunosuppressive properties

S. D. Gorman, L. Chatenoud, H. Waldmann, 1993, European journal of immunology.

Helplessness as a strategy for avoiding antiglobulin responses to therapeutic monoclonal antibodies.

J. Isaacs, H. Waldmann, 1994, Therapeutic immunology.

Reprogramming the immune system: co‐receptor blockade as a paradigm for harnessing tolerance mechanisms

H. Waldmann, S. Cobbold, E. Adams, 2008, Immunological reviews.

Human CD3 Transgenic Mice: Preclinical Testing of Antibodies Promoting Immune Tolerance

P. van Endert, G. Hale, L. Chatenoud, 2011, Science Translational Medicine.

Title Minimum Information about T Regulatory Cells : A Step toward Reproducibility and Standardization Permalink

D. Hafler, J. Bluestone, J. Isaacs, 2018 .

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization

D. Hafler, J. Bluestone, J. Isaacs, 2018, Front. Immunol..

Pharmacokinetics and Antibody Responses to the CD3 Antibody Otelixizumab Used in the Treatment of Type 1 Diabetes

W. Jusko, C. Mathieu, G. Hale, 2010, Journal of clinical pharmacology.

Tolerogenicity is not an absolute property of a dendritic cell

H. Waldmann, S. Cobbold, N. Saunders, 2010, European journal of immunology.

The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells

Daniel Metzger, Herman Waldmann, Pierre Chambon, 2011, Nature communications.

Heterogeneity of natural Foxp3+ T cells: A committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity

B. Malissen, H. Waldmann, S. Hori, 2009, Proceedings of the National Academy of Sciences.

Regulatory cells and transplantation tolerance.

H. Waldmann, S. Cobbold, 2013, Cold Spring Harbor perspectives in medicine.

Gene Expression in the Gitr Locus Is Regulated by NF-κB and Foxp3 through an Enhancer

Chihiro Ogawa, H. Waldmann, Christian Peter, 2014, The Journal of Immunology.

TGF-β–Mediated Foxp3 Gene Expression Is Cooperatively Regulated by Stat5, Creb, and AP-1 through CNS2

Chihiro Ogawa, H. Waldmann, Christian Peter, 2014, The Journal of Immunology.

Activation rather than Foxp3 expression determines that TGF‐β‐induced regulatory T cells out‐compete naïve T cells in dendritic cell clustering

A. G. Betz, F. Regateiro, H. Waldmann, 2012, European journal of immunology.

A Role for Regulatory T Cells in Acceptance of ESC‐Derived Tissues Transplanted Across an Major Histocompatibility Complex Barrier

Kathy O. Lui, H. Waldmann, S. Cobbold, 2010, Stem cells.

MS 4 A 4 B Is a GITR-Associated Membrane Adapter , Expressed by Regulatory T Cells , Which Modulates T Cell Activation 1

H. Waldmann, S. Cobbold, N. Saunders, 2009 .

MS4A4B Is a GITR-Associated Membrane Adapter, Expressed by Regulatory T Cells, Which Modulates T Cell Activation1

H. Waldmann, S. Cobbold, N. Saunders, 2009, The Journal of Immunology.

Cooperation across the histocompatibility barrier: H2d T cells primed to antigen in an H-2d environment can cooperate with H-2k B cells

H. Waldmann, H. Pope, A. Munro, 1976, The Journal of experimental medicine.

The use of monoclonal antibodies to achieve immunological tolerance.

H. Waldmann, S. Cobbold, 1993, Trends in pharmacological sciences.

Long-term remission of intractable systemic vasculitis with monoclonal antibody therapy

J. Isaacs, G. Hale, S. Thiru, 1993, The Lancet.

Structure and chromosomal location of mouse and human CD52 genes.

H. Waldmann, K. F. Nolan, Y. Tone, 1999, Biochimica et biophysica acta.

A humanized CD18 antibody can block function without cell destruction.

M. Lockyer, G. Hale, H. Waldmann, 1993, Journal of Immunology.

A Novel Role for Triglyceride Metabolism in Foxp3 Expression

H. Waldmann, S. Cobbold, B. Kessler, 2019, Front. Immunol..

Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells

S. Kaufmann, H. Waldmann, S. Cobbold, 1987, Infection and immunity.

Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase.

B. Baban, D. Munn, H. Waldmann, 2004, International immunology.

Self tolerance is H–2-restricted

H. Waldmann, R. Zamoyska, P. Matzinger, 1984, Nature.

Monocytic origin of foam cells in human atherosclerotic plaques.

H. Waldmann, M. J. Mitchinson, H. Waldmann, 1984, Atherosclerosis.

A pilot study of combination anti-cytokine and anti-lymphocyte biological therapy in rheumatoid arthritis.

P. Emery, G. Hale, H. Waldmann, 2008, QJM : monthly journal of the Association of Physicians.

Embryonic stem cell-derived tissues are immunogenic but their inherent immune privilege promotes the induction of tolerance

H. Waldmann, S. Cobbold, N. Robertson, 2007, Proceedings of the National Academy of Sciences.

Immunoglobulin heavy chain locus of the rat: striking homology to mouse antibody genes.

M. Brüggemann, H. Waldmann, S. Cobbold, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Regulatory T cells and transplantation tolerance: Emerging from the darkness?

H. Waldmann, 2021 .

Mechanism of first-dose cytokine-release syndrome by CAMPATH 1-H: involvement of CD16 (FcgammaRIII) and CD11a/CD18 (LFA-1) on NK cells.

A. Compston, J. Isaacs, A. Compston, 1996, The Journal of clinical investigation.

Structure and chromosomal location of the mouse interleukin‐12 p35 and p40 subunit genes

H. Waldmann, K. F. Nolan, J. Babik, 1996, European journal of immunology.

Clinical evidence of a graft-versus-Hodgkin's-lymphoma effect after reduced-intensity allogeneic transplantation

C. Craddock, S. Mackinnon, K. Peggs, 2005, The Lancet.

Transplantation tolerance: the big picture. Where do we stand, where should we go?

H. Waldmann, 2017, Clinical and experimental immunology.

Reprogramming the immune system

H. Waldmann, 2002, Clinical transplants.

Approaching Tolerance in Transplantation

H. Waldmann, S. Cobbold, 2001, International Archives of Allergy and Immunology.

Humanized anti‐CD4 monoclonal antibody therapy of autoimmune and inflammatory disease

M. Keogan, G. Hale, H. Waldmann, 1997, Clinical and experimental immunology.

Tolerance induction in the adult: 'danger' at Le Bischenberg.

F. Emmrich, L. Chatenoud, H. Waldmann, 1995, Immunology today.

A Theoretical Framework for Self-tolerance and its Relevance to Therapy of Autoimmune Disease

H. Waldmann, S. Cobbold, S. Qin, 1988 .

Enhanced Production of IL-10 by Dendritic Cells Deficient in CIITA1

H. Waldmann, Yongxue Yao, Cheong-Hee Chang, 2005, The Journal of Immunology.

B and T cells in immune recognition: Edited by F. Loor and G.E. Roelands, Pp. 504. John Wiley & Sons Ltd. 1977. £18.50

H. Waldmann, 1977 .

Prospects for ensuring acceptance of ES cell-derived tissues

H. Waldmann, K. O. Lui, P. Fairchild, 2010 .

Serial analysis of gene expression provides new insights into regulatory T cells.

H. Waldmann, S. Cobbold, L. Graça, 2003, Seminars in immunology.

The CD59 antigen--a multifunctional molecule.

S. Thiru, H. Waldmann, M. Tone, 1992, Tissue antigens.

Human protectin (CD59), an 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers.

S. Meri, P. Lachmann, H. Waldmann, 1990, Immunology.

Induction of dominant transplantation tolerance by an altered peptide ligand of the male antigen Dby.

H. Waldmann, P. Fairchild, Tse-Ching Chen, 2004, The Journal of clinical investigation.

The use of monoclonal antibodies to achieve immunological tolerance.

H. Waldmann, S. Cobbold, H. Waldmann, 1993, Immunology today.

Human Monoclonal Antibodies: The Benefits of Humanization.

H. Waldmann, 2018, Methods in molecular biology.

Human monoclonal antibodies: the residual challenge of antibody immunogenicity.

H. Waldmann, 2014, Methods in molecular biology.

DIABETIC STUDIES The Review of Chapter IV . 2 CD 3 Monoclonal Antibodies : A First Step Towards Operational Immune Tolerance in the Clinic

L. Chatenoud, H. Waldmann, 2013 .

CD3 monoclonal antibodies: a first step towards operational immune tolerance in the clinic.

L. Chatenoud, H. Waldmann, 2012, The review of diabetic studies : RDS.

Optimism after much pessimism: what next?

C. Milstein, H. Waldmann, 1999, Current opinion in immunology.

Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells.

L. Chatenoud, H. Waldmann, S. Cobbold, 2005, Diabetes.

Remission Induction in Patients with Lymphoid Malignancies Using Unconjugated CAMPATH-1 Monoclonal Antibodies.

M. Dyer, R. Marcus, G. Hale, 1990, Leukemia & lymphoma.

A Bacterial Artificial Chromosome Reporter System for Expression of the Human FOXP3 Gene in Mouse Regulatory T-Cells

Chihiro Ogawa, H. Waldmann, E. Masuda, 2017, Front. Immunol..

Therapeutic aspects of tolerance.

H. Waldmann, S. Cobbold, E. Adams, 2001, Current opinion in pharmacology.

Transplantation tolerance—where do we stand?

H. Waldmann, 1999, Nature Medicine.

A personal history of the CAMPATH-1H antibody

H. Waldmann, 2002, Medical oncology.

Engineering multiple-domain forms of the therapeutic antibody CAMPATH-1H: effects on complement lysis.

S. D. Gorman, H. Waldmann, J. Greenwood, 1994, Therapeutic immunology.

Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis

A. Compston, A. Coles, G. Hale, 1999, The Lancet.

Cell replacement therapy and the evasion of destructive immunity

H. Waldmann, N. Robertson, K. F. Nolan, 2007, Stem Cell Reviews.

Activated polyamidoamine dendrimers, a non-viral vector for gene transfer to the corneal endothelium

J. Isaacs, H. Waldmann, D. Larkin, 1999, Gene Therapy.

The major histocompatibility system and the immune response.

H. Waldmann, A. Munro, 1978, British medical bulletin.

IMPORTANCE OF ANTIGEN SPECIFICITY FOR COMPLEMENT‐MEDIATED LYSIS BY MONOCLONAL ANTIBODIES

H. Waldmann, C. Bindon, Geoffrey Hale And, 1988, European journal of immunology.

Anti-CD45 monoclonal antibody YAML568: A promising radioimmunoconjugate for targeted therapy of acute leukemia.

G. Glatting, S. Reske, K. Hohl, 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Nutrient Sensing via mTOR in T Cells Maintains a Tolerogenic Microenvironment

H. Waldmann, S. Cobbold, D. Howie, 2014, Front. Immunol..

CD4+ T Cell Fate Decisions Are Stochastic, Precede Cell Division, Depend on GITR Co-Stimulation, and Are Associated With Uropodium Development

H. Waldmann, S. Cobbold, E. Adams, 2018, bioRxiv.

Coreceptor blockade targeting CD4 and CD8 allows acceptance of allogeneic human pluripotent stem cell grafts in humanized mice.

Kathy O. Lui, Zhiwei Chen, H. Waldmann, 2020, Biomaterials.

Therapy with monoclonal antibodies. II. The contribution of Fc gamma receptor binding and the influence of C(H)1 and C(H)3 domains on in vivo effector function.

J. Isaacs, H. Waldmann, J. Greenwood, 1998, Journal of immunology.

Extrathymic signals regulate the onset of T cell repertoire selection

H. Waldmann, P. Fairchild, 2000, European journal of immunology.

Infectious tolerance. What are we missing?

H. Waldmann, L. Graça, 2020, Cellular immunology.

Induction of Immunological Tolerance as a Therapeutic Procedure.

H. Waldmann, S. Cobbold, D. Howie, 2016, Microbiology spectrum.

(anti-CD40L) monoclonal antibody under nonmyeloablative conditions Requirements for the promotion of allogeneic engraftment by anti-CD154

H. Waldmann, R. Noelle, B. Blazar, 2013 .

Regulation and Privilege in Transplantation Tolerance

H. Waldmann, S. Cobbold, E. Adams, 2008, Journal of Clinical Immunology.

Regulatory T-cells in Therapeutic Transplantation Tolerance

H. Waldmann, S. Cobbold, E. Adams, 2008 .

Targeting CD4 for the induction of dominant tolerance

H. Waldmann, S. Cobbold, E. Adams, 2008 .

Infectious tolerance and the long‐term acceptance of transplanted tissue

H. Waldmann, S. Cobbold, E. Adams, 2006, Immunological reviews.

Harmless Antigen Cells following Prolonged Exposure to a Generation of Anergic and Regulatory T

H. Waldmann, S. Cobbold, P. Fairchild, 2004 .

Generation of Anergic and Regulatory T Cells following Prolonged Exposure to a Harmless Antigen 1

H. Waldmann, S. Cobbold, P. Fairchild, 2004, The Journal of Immunology.

Regulatory T cells and organ transplantation.

H. Waldmann, S. Cobbold, L. Graça, 2004, Seminars in immunology.

Antibody-induced transplantation tolerance

H. Waldmann, S. Cobbold, L. Graça, 2003, Immunologic research.

Requirements for the promotion of allogeneic engraftment by anti-CD154 (anti-CD40L) monoclonal antibody under nonmyeloablative conditions.

H. Waldmann, R. Noelle, B. Blazar, 2001, Blood.

Alopecia areata: Animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies.

R. Paus, H. Waldmann, Amos Etzioni, 2016, Autoimmunity reviews.

In Vivo Kinetics of GITR and GITR Ligand Expression and Their Functional Significance in Regulating Viral Immunopathology

B. Rouse, H. Waldmann, Bumseok Kim, 2005, Journal of Virology.

Exploiting Tolerance Processes in Transplantation

H. Waldmann, S. Cobbold, 2004, Science.

Enhancement of humoral and cellular immunity with an anti‐glucocorticoid‐induced tumour necrosis factor receptor monoclonal antibody

H. Waldmann, L. Vaickus, M. Rosenzweig, 2010, Immunology.

Regulatory T cells and transplantation tolerance.

H. Waldmann, S. Cobbold, D. Howie, 2008, Immunotherapy.

Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells

J. Aerts, H. Waldmann, C. Heirman, 2007, Journal of leukocyte biology.

Enhanced murine contact hypersensitivity by depletion of endogenous regulatory T cells in the sensitization phase.

H. Waldmann, T. Honda, K. Kabashima, 2011, Journal of dermatological science.

Foxp3+ T reg cells control psoriasiform inflammation by restraining an IFN-I–driven CD8+ T cell response

G. Ogg, F. Powrie, N. Ilott, 2018, The Journal of experimental medicine.

Chantal Kuhn Promoting Immune Tolerance Human CD 3 Transgenic Mice : Preclinical Testing of Antibodies

G. Hale, L. Chatenoud, H. Waldmann, 2011 .

The effect of the serotherapy regimen used and the marrow cell dose received on rejection, graft-versus-host disease and outcome following unrelated donor bone marrow transplantation for leukaemia

N. Russell, J. Byrne, N. Russell, 2000, Bone Marrow Transplantation.

Children with acute lymphoblastic leukemia who receive T-cell-depleted HLA mismatched marrow allografts from unrelated donors have an increased incidence of primary graft failure but a similar overall transplant outcome.

G. Hale, H. Waldmann, J. Cornish, 1999, Blood.

Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients

P. Friend, G. Hale, H. Waldmann, 1998, The Lancet.

Regaining self-control--regulation and immunotherapy.

J. Isaacs, H. Waldmann, 1998, British journal of rheumatology.

Regulation of IL-18 (IFN-gamma-inducing factor) gene expression.

H. Waldmann, P. Fairchild, Y. Tone, 1997, Journal of immunology.

Immunomodulation of dog islets using a cocktail of monoclonal antibodies

H. Waldmann, R. Calne, S. Cobbold, 1992 .

Immunomodulation of dog islets using a cocktail of monoclonal antibodies.

H. Waldmann, R. Calne, S. Cobbold, 1992, Transplant international : official journal of the European Society for Organ Transplantation.

Induced Foxp3+ T Cells Colonizing Tolerated Allografts Exhibit the Hypomethylation Pattern Typical of Mature Regulatory T Cells

H. Waldmann, S. Cobbold, E. Adams, 2016, Front. Immunol..

Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance

F. Regateiro, H. Waldmann, Jianbo Ma, 2011, The Journal of experimental medicine.

Biomarkers of Transplantation Tolerance: More Hopeful than Helpful?

H. Waldmann, S. Cobbold, E. Adams, 2011, Front. Immun..

Induction of Regulatory T Cells and Dominant Tolerance by Dendritic Cells Incapable of Full Activation1

H. Waldmann, S. Cobbold, N. Saunders, 2007, The Journal of Immunology.

The new immunosuppression.

H. Waldmann, 2003, Current opinion in chemical biology.

Risks of developing Epstein-Barr virus-related lymphoproliferative disorders after T-cell-depleted marrow transplants. CAMPATH Users.

G. Hale, H. Waldmann, 1998, Blood.

A therapeutic human IgG4 monoclonal antibody that depletes target cells in humans

B. Hazleman, J. Isaacs, G. Hale, 1996, Clinical and experimental immunology.

CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells

D L Simmons, P. Lachmann, G. Hale, 1989, The Journal of experimental medicine.

Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement.

G. Hale, H. Waldmann, D. Metcalf, 1983, Blood.

The CAMPATH-1 antigen (CDw52).

G. Hale, H. Waldmann, H. Tighe, 1990, Tissue antigens.

Identification of cells of the human mononuclear phagocyte system with rat monoclonal antibodies

H. Waldmann, D. Jones, M. Clark, 1987, The Journal of pathology.

CD4 T cells can reject major histocompatibility complex class I‐incompatible skin grafts

D. Zélénika, F. Bemelman, H. Waldmann, 1999, European journal of immunology.

Human Complement-Fixing Antibodies in Transplantation

G. Hale, H. Waldmann, 1985 .

Induction of tolerance in peripheral T cells with monoclonal antibodies

H. Waldmann, S. Cobbold, J. Parnes, 1990, European journal of immunology.

Embryonic stem cells: a novel source of dendritic cells for clinical applications.

H. Waldmann, K. F. Nolan, P. Fairchild, 2005, International immunopharmacology.

Alemtuzumab (CAMPATH-1H) for the Treatment of Acute Rejection in Kidney Transplant Recipients: Long-Term Follow-Up

M. Clatworthy, P. Friend, G. Hale, 2009, Transplantation.

Blood concentrations of alemtuzumab and antiglobulin responses in patients with chronic lymphocytic leukemia following intravenous or subcutaneous routes of administration.

E. Kimby, C. Fegan, G. Hale, 2004, Blood.

The effect of treatment with Campath‐1H in patients with autoimmune cytopenias

W. Ouwehand, H. Waldmann, D. Bevan, 2001, British journal of haematology.

Appropriate targets for monoclonal antibodies in the induction of transplantation tolerance.

G. Hale, H. Waldmann, S. Cobbold, 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

In vivo CAMPATH-1H prevents GvHD following nonmyeloablative stem-cell transplantation.

G. Morgan, S. Mackinnon, S. Verfuerth, 2001, Cytotherapy.

Semi-specific immuno-absorption and monoclonal antibody therapy in ANCA positive vasculitis: experience in four cases.

G. Hale, H. Waldmann, C. Lockwood, 1998, Autoimmunity.

Sustained remission of severe resistant autoimmune neutropenia with Campath‐1H

H. Waldmann, S. Killick, E. Gordon-Smith, 1997, British journal of haematology.

Treatment of refractory Wegener's granulomatosis with humanized monoclonal antibodies.

S. Stewart, J. Isaacs, G. Hale, 1996, QJM : monthly journal of the Association of Physicians.

Monoclonal antibody therapy of diffuse cutaneous scleroderma with CAMPATH-1H.

B. Hazleman, K. Chakravarty, J. Isaacs, 1996, The Journal of rheumatology.

Monoclonal antibody therapy of chronic intraocular inflammation using Campath-1H.

A. Dick, J. Isaacs, G. Hale, 1995, The British journal of ophthalmology.

Prevention of immune-mediated corneal graft destruction with the anti-lymphocyte monoclonal antibody, CAMPATH-1H

J. Isaacs, G. Hale, H. Waldmann, 1995, Eye.

Efficient complement-mediated lysis of cells containing the CAMPATH-1 (CDw52) antigen.

G. Hale, H. Waldmann, H. Waldmann, 1993, Molecular immunology.

HUMANIZED MONOCLONAL-ANTIBODY THERAPY IN RHEUMATOID-ARTHRITIS

J. Isaacs, G. Hale, H. Waldmann, 1992 .

Purging in auto- and allografts: monoclonal antibodies which use human complement and other natural effector mechanisms.

G. Hale, H. Waldmann, S. Cobbold, 1990, Progress in clinical and biological research.

Campath-1M--prophylactic use after kidney transplantation. A randomized controlled clinical trial.

S. Gore, P. Friend, G. Hale, 1989, Transplantation.

Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid malignancies: influence of antibody isotype.

M. Dyer, G. Hale, H. Waldmann, 1989, Blood.

T CELL DEPLETION WITH CAMPATH‐1 IN ALLOGENEIC BONE MARROW TRANSPLANTATION

G. Hale, H. Waldmann, S. Cobbold, 1988, Transplantation.

Monoclonal antibodies as agents to reinduce tolerance in autoimmunity.

H. Waldmann, S. Cobbold, S. Qin, 1992, Journal of autoimmunity.

Do L3T4+ T cells act as effector cells in protection against influenza virus infection.

H. Waldmann, S. Cobbold, S. Lightman, 1987, Immunology.

The Role of Sp1 and NF-κB in Regulating CD40 Gene Expression*

H. Waldmann, J. Babik, Y. Tone, 2002, The Journal of Biological Chemistry.

The role of Sp1 and NF-kappa B in regulating CD40 gene expression.

H. Waldmann, J. Babik, Y. Tone, 2002, The Journal of biological chemistry.

Monoclonal-antibody therapy in systemic vasculitis.

G. Hale, H. Waldmann, P. Mathieson, 1990, The New England journal of medicine.

Thomas' hematopoietic cell transplantation

H. Waldmann, 2005, Bone Marrow Transplantation.

Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL).

E. Kimby, L. Möllgård, G. Hale, 2002, Blood.

Infectious tolerance.

H. Waldmann, S. Cobbold, H. Waldmann, 1998, Current opinion in immunology.

Bone marrow transplantation for patients with chronic myeloid leukaemia: T-cell depletion with Campath-1 reduces the incidence of graft-versus-host disease but may increase the risk of leukaemic relapse.

R. Marcus, H. Waldmann, J. Apperley, 1986, Bone marrow transplantation.

Tolerance induction with CD4 monoclonal antibodies.

F. Bemelman, H. Waldmann, S. Cobbold, 1998, Novartis Foundation symposium.

Functional analysis of T lymphocyte subsets in antiviral host defense.

R. Zinkernagel, H. Waldmann, S. Cobbold, 1987, Journal of immunology.

The induction and Maintenance of Transplant Tolerance engages Both regulatory and anergic cD 4 + T cells

L. Chatenoud, H. Waldmann, S. You, 2019 .

The Induction and Maintenance of Transplant Tolerance Engages Both Regulatory and Anergic CD4+ T cells

L. Chatenoud, H. Waldmann, S. You, 2017, Front. Immunol..

Amplification of natural regulatory immune mechanisms for transplantation tolerance.

S. Metcalfe, H. Waldmann, S. Cobbold, 1996, Transplantation.

Defining and overcoming the immunological barriers to stem cell therapies.

H. Waldmann, N. Robertson, P. Fairchild, 2008 .

Tolerance can be infectious

H. Waldmann, 2008, Nature Immunology.

Advantages of rat monoclonal antibodies.

G. Hale, H. Waldmann, S. Cobbold, 1983, Immunology today.

Infectious tolerance: therapeutic potential.

H. Waldmann, A. Kendal, 2010, Current opinion in immunology.

Connecting the mechanisms of T‐cell regulation: dendritic cells as the missing link

F. Regateiro, H. Waldmann, S. Cobbold, 2010, Immunological reviews.

Non-depleting anti-CD4 monoclonal antibody induces immune tolerance to ERT in a murine model of Pompe disease

H. Waldmann, A. Rosenberg, A. D. de Fougerolles, 2014, Molecular genetics and metabolism reports.

Induction of Immunological Tolerance/Hyporesponsiveness in Baboons with a Nondepleting CD4 Antibody

H. Waldmann, S. Cobbold, P. Rao, 2004, The Journal of Immunology.

This information is current as with a Nondepleting CD 4 Antibody Tolerance / Hyporesponsiveness in Baboons Induction of Immunological

H. Waldmann, S. Cobbold, P. Rao, 2004 .

Humanized monoclonal antibody treatment in rheumatoid arthritis.

B. Hazleman, G. Hale, H. Waldmann, 1991, The Journal of rheumatology.

Pediatric immunohematopoietic stem cell transplantation at a tertiary care center in Cape Town.

G. Hale, H. Waldmann, J. Lund, 2008, Hematology/oncology and stem cell therapy.

A humanised therapeutic CD4 mAb inhibits TCR-induced IL-2, IL-4, and IL-10 secretion and expression of CD25, CD40L, and CD69.

D. Alexander, H. Waldmann, M. Glennie, 1998, Cellular immunology.

EFFECT OF GRAFT PERFUSION WITH TWO CD45 MONOCLONAL ANTIBODIES ON INCIDENCE OF KIDNEY ALLOGRAFT REJECTION

M. Bewick, G. Hale, H. Waldmann, 1989, The Lancet.

Genetic modification of dendritic cells through the directed differentiation of embryonic stem cells.

H. Waldmann, K. F. Nolan, P. Fairchild, 2007, Methods in molecular biology.

Separation of hemopoietic cells from adult mouse marrow by use of monoclonal antibodies.

Waldmann, T. Hoang, H. Waldmann, 1983, Blood.

Non-myeloablative allogeneic transplantation for high-risk acute leukemia and myelodysplasia.

C. Craddock, S. Mackinnon, K. Peggs, 2001 .

CD52 antibodies for prevention of graft-versus-host disease and graft rejection following transplantation of allogeneic peripheral blood stem cells

G. Hale, H. Waldmann, W. Fibbe, 2000, Bone Marrow Transplantation.

Evaluation of non-myeloablative conditioning combining beam with in vivo pre-transplant Campath-IG for allogeneic transplantation in patients with lymphoma.

J. Byrne, N. Russell, G. Hale, 1999 .

A non myeloablative regimen for allografting high-risk patients: Low toxicity, stable engraftment without GVHD, disease control and potential for GVL with adoptive immunotherapy.

S. Mackinnon, H. Waldmann, D. Linch, 1999 .

RESPONSES WITH MONOCLONAL ANTIBODIES

H. Waldmann, 1989 .

T‐ and B‐cell immune reconstitution and clinical outcome in patients with multiple myeloma receiving T‐cell‐depleted, reduced‐intensity allogeneic stem cell transplantation with an alemtuzumab‐containing conditioning regimen followed by escalated donor lymphocyte infusions

S. Mackinnon, K. Peggs, S. Verfuerth, 2003, British journal of haematology.

Reconstitution of the Epstein-Barr virus-specific cytotoxic T-lymphocyte response following T-cell-depleted myeloablative and nonmyeloablative allogeneic stem cell transplantation.

D. Pillay, C. Fegan, S. Mackinnon, 2003, Blood.

Immune reconstitution after allogeneic bone marrow transplantation depleted of T cells.

G. Hale, H. Waldmann, A. Kline, 2000, Transplantation.

LEUKAEMIC RELAPSE AFTER CAMPATH 1-TREATED BONE-MARROW TRANSPLANTATION FOR LEUKAEMIA

G. Hale, H. Waldmann, S. Cobbold, 1987, The Lancet.

ELIMINATION OF GRAFT-VERSUS-HOST DISEASE BY IN-VITRO DEPLETION OF ALLOREACTIVE LYMPHOCYTES WITH A MONOCLONAL RAT ANTI-HUMAN LYMPHOCYTE ANTIBODY (CAMPATH-1)

G. Hale, H. Waldmann, C. Brautbar, 1984, The Lancet.

Excessive T cell depletion of peripheral blood stem cells has an adverse effect upon outcome following allogeneic stem cell transplantation

S. Mackinnon, H. Waldmann, D. Linch, 2001, Bone Marrow Transplantation.

SAGE analysis of cell types involved in tolerance induction.

H. Waldmann, S. Cobbold, K. F. Nolan, 2007, Methods in molecular biology.

Double T cell depletion of bone marrow using sequential positive and negative cell immunoaffinity or CD34+ cell selection followed by Campath-1M; effect on CD34+ cells and progenitor cell recoveries

H. Waldmann, J. Cornish, A. Oakhill, 1998, Bone Marrow Transplantation.

Deciphering thymic development

H. Waldmann, Kendall A. Smith, 2014 .

A novel role for Glucocorticoid-Induced TNF Receptor Ligand (Gitrl) in early embryonic zebrafish development.

C. Anastasaki, H. Waldmann, K. F. Nolan, 2010, The International journal of developmental biology.

Interactions between T and B Cells: A Review

H. Waldmann, 1979, Journal of the Royal Society of Medicine.

Immunogenicity of Biological Therapies A Novel Strategy To Reduce the

A. Compston, A. Coles, G. Hale, 2010 .

Guiding Postablative Lymphocyte Reconstitution as a Route Toward Transplantation Tolerance

H. Waldmann, S. Cobbold, E. Adams, 2014, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Universal bispecific antibody for targeting tumor cells for destruction by cytotoxic T cells.

H. Waldmann, M. Clark, L. Gilliland, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Isolation of low-frequency class-switch variants from rat hybrid myelomas.

G. Hale, H. Waldmann, S. Cobbold, 1987, Journal of immunological methods.

Selective Depletion of Alloreactive Cells in Transplantation

H. Waldmann, 1993 .

Tolerance Induction Using CD4 and CD8 Monoclonal Antibodies

H. Waldmann, S. Cobbold, S. Qin, 1989 .

Exacerbation of delayed-type hypersensitivity responses in EBV-induced gene-3 (EBI-3)-deficient mice.

H. Waldmann, Honglian Tong, S. Hori, 2010, Immunology letters.

Immunohistological screening in the selection of monoclonal antibodies: the use of isotype-specific antiglobulins.

H. Waldmann, S. Cobbold, M. Clark, 1984, Journal of immunological methods.

A noncomitogenic CD2R monoclonal antibody induces apoptosis of activated T cells by a CD95/CD95-L-dependent pathway.

E. Robinet, H. Waldmann, G. Bismuth, 1998, Journal of immunology.

CD 95 / CD 95-L-Dependent Pathway Induces Apoptosis of Activated T Cells by a A Noncomitogenic CD 2 R Monoclonal Antibody Bismuth

E. Robinet, H. Waldmann, G. Bismuth, 1998 .

CD52-Negative NK Cells Are Abundant in the Liver and Less Susceptible to Alemtuzumab Treatment

H. Ohdan, C. Ricordi, H. Waldmann, 2016, PloS one.

Rat monoclonal antibodies for bone marrow transplantation--the CAMPATH series.

H. Waldmann, S. Cobbold, S. Watt, 1985, Advances in experimental medicine and biology.

Donor-specific transplantation tolerance: the paradoxical behavior of CD4+CD25+ T cells.

H. Waldmann, S. Cobbold, L. Graça, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Enhanced Production of IL-10 by Dendritic

H. Waldmann, Yongxue Yao, Cheong-Hee Chang, 2005 .

The new immunosuppression: just kill the T cell

H. Waldmann, 2003, Nature Medicine.

The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci.

D. Greaves, H. Waldmann, K. F. Nolan, 1998, Genomics.

Infectious tolerance via the consumption of essential amino acids and mTOR signaling

Kathy O. Lui, Elizabeth Adams, Herman Waldmann, 2009, Proceedings of the National Academy of Sciences.

The role of CD4+ T‐cell subsets in determining transplantation rejection or tolerance

D. Zélénika, H. Waldmann, S. Cobbold, 2001, Immunological reviews.

CD4 mAbs prevent progression of alloactivated CD4+ T cells into the S phase of the cell cycle without interfering with early activation signals.

J. Phillips, E. Robinet, H. Waldmann, 1996, Transplantation.

Comparison of allogeneic T cell-depleted peripheral blood stem cell and bone marrow transplantation: effect of stem cell source on short- and long-term outcome

J. Falkenburg, R. Willemze, H. Waldmann, 2001, Bone Marrow Transplantation.

The vaccinia virus C12L protein inhibits mouse IL-18 and promotes virus virulence in the murine intranasal model.

D. Tscharke, H. Waldmann, Geoffrey L. Smith, 2002, The Journal of general virology.

Therapeutic approaches for transplantation.

H. Waldmann, Herman Waldmann, 2001, Current opinion in immunology.

Pharmacologically Modified Dendritic Cells: A Route to Tolerance‐associated Genes

H. Waldmann, S. Yates, A. Paterson, 2008 .

Monoclonal antibodies for immunosuppression.

P. Friend, H. Waldmann, S. Cobbold, 1988, Progress in allergy.

Effects of monoclonal anti-lymphocyte antibodies in vivo in monkeys and humans.

G. Hale, H. Waldmann, D. Swirsky, 1983, Molecular biology & medicine.

The development of insulin-dependent diabetes mellitus in non-obese diabetic mice: the role of CD4+ and CD8+ T cells.

A. Cooke, H. Waldmann, L. O'Reilly, 1991, Biochemical Society transactions.

The involvement of Ly2+ T cells in beta cell destruction.

A. Cooke, H. Waldmann, L. O'Reilly, 1990, Journal of autoimmunity.

Therapeutic potential of rat monoclonal antibodies: isotype specificity of antibody-dependent cell-mediated cytotoxicity with human lymphocytes.

G. Hale, H. Waldmann, M. Clark, 1985, Journal of immunology.

Limiting Dilution Analysis

H. Waldmann, 1998 .

Enhanced efficacy from gene therapy in Pompe disease using coreceptor blockade.

H. Waldmann, Songtao Li, C. Leborgne, 2015, Human gene therapy.

Structure of the CAMPATH-1 antigen, a glycosylphosphatidylinositol-anchored glycoprotein which is an exceptionally good target for complement lysis.

M. Ferguson, G. Hale, H. Waldmann, 1993, The Biochemical journal.

The influence of thymus on the development of MHC restrictions exhibited by T-helper cells

H. Waldmann, A. Davies, H. Pope, 1979, Nature.

Influence of the major histocompatibility complex on lymphocyte interactions in antibody formation

H. Waldmann, H. Pope, L. Brent, 1978, Nature.

In vivo‘Purging’ of residual disease in CLL with Campath‐1H

M. Dyer, D. Catovsky, H. Waldmann, 1997, British journal of haematology.

Monoclonal antibodies for organ transplantation: prospects for the future.

H. Waldmann, 1988, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Dendritic cells and prospects for transplantation tolerance.

H. Waldmann, P. Fairchild, Herman Waldmann, 2000, Current opinion in immunology.

Favorable effect on acute and chronic graft-versus-host disease with cyclophosphamide and in vivo anti-CD52 monoclonal antibodies for marrow transplantation from HLA-identical sibling donors for acquired aplastic anemia.

G. Hale, H. Waldmann, Vikas Gupta, 2004, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients.

C. Mathieu, J. Seigneurin, G. Hale, 2010, Blood.

Myeloablative conditioning is well tolerated by older patients receiving T-cell-depleted grafts

G. Hale, H. Waldmann, G. Hale, 2005, Bone Marrow Transplantation.

G. Hale, H. Waldmann, J. Cornish, 1996, British journal of haematology.

Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis

A. Compston, P. Molyneux, A. Coles, 1999, Annals of neurology.

From Laboratory to Clinic : The Story of CAM PA TH-1.

G. Hale, H. Waldmann, 2000, Methods in molecular medicine.

Induction of tolerance by monoclonal antibody therapy

H. Waldmann, R. Benjamin, H. Waldmann, 1986, Nature.

The inter-relationship of antigenic structure, thymus-independence and adjuvanticity. IV. A general model for B-cell induction.

H. Waldmann, A. Munro, 1975, Immunology.

Co-operation across histocompatibility differences. The role of inhibitory T cells in preventing successful T-B interaction.

H. Waldmann, H. Pope, G. Kenny, 1977, Immunology.

Conditions Determining the Generation and Expression of T Helper Cells

H. Waldmann, 1977, Immunological reviews.

Interaction of rat monoclonal antibodies with human killer cells.

G. Hale, H. Waldmann, M. Clark, 1984, Advances in experimental medicine and biology.

THERAPEUTIC POTENTIAL OF RAT MONOCLONAL ANTIBODIES: ISOTYPE WITH HUMAN LYMPHOCYTES SPECIFICITY OF ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY

G. Hale, H. Waldmann, M. Clark, 1985 .

Restriction in the function of single helper T cells.

H. Waldmann, I. Lefkovits, A. Feinstein, 1976, Immunology.

Lennox and H Waldmann

T. Hoang, H. Waldmann, F. Grunert, 2003 .

Immunosuppression with monoclonal antibodies--rules for effective serotherapy.

H. Waldmann, S. Cobbold, P. Lovat, 1985, Advances in experimental medicine and biology.

What can be done to prevent graft versus host disease?

G. Hale, H. Waldmann, S. Cobbold, 1994, Current opinion in immunology.

Immunosuppression of canine renal allograft recipients by CD4 and CD8 monoclonal antibodies.

S. Metcalfe, P. Rebello, S. Thiru, 1994, Tissue antigens.

The improved lytic function and in vivo efficacy of monovalent monoclonal CD3 antibodies

P. Friend, G. Hale, H. Waldmann, 1989, European journal of immunology.

Resistance to collagen-induced arthritis in DBA/1 mice by intraperitoneal administration of soluble type II collagen involves both CD4+ and CD8+ T lymphocytes.

H. Waldmann, A. Whyte, R. Williams, 1989, Autoimmunity.

Monoclonal antibodies for the depletion of specific subpopulations of lymphocytes.

H. Waldmann, S. Cobbold, S. Qin, 1987, Ciba Foundation symposium.

Reactivity of rat monoclonal antibody CAMPATH‐1 with human leukaemia cells and its possible application for autologous bone marrow transplantation

G. Hale, H. Waldmann, D. Swirsky, 1985, British journal of haematology.

Therapeutic potential of monoclonal antibodies to the leucocyte common antigen.

G. Hale, H. Waldmann, C. Bindon, 1985, Advances in experimental medicine and biology.

Therapeutic potential of monovalent monoclonal antibodies

H. Waldmann, S. Cobbold, 1984, Nature.

Detection of monoclonal antibodies against cell surface antigens: the use of antiglobulins coupled to red blood cells.

H. Waldmann, S. Cobbold, M. Clark, 1984, Journal of immunological methods.

In vivo CAMPATH-1H prevents graft-versus-host disease following nonmyeloablative stem cell transplantation.

G. Morgan, S. Mackinnon, K. Peggs, 2000, Blood.

Reduced-intensity transplantation with in vivo T-cell depletion and adjuvant dose-escalating donor lymphocyte infusions for chemotherapy-sensitive myeloma: limited efficacy of graft-versus-tumor activity.

S. Mackinnon, K. Peggs, G. Hale, 2003, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Apoptosis: potential for disease therapies.

M. Goldman, H. Waldmann, D. Kabelitz, 1998, Immunology today.

The use of a non‐depleting anti‐CD4 monoclonal antibody to re‐establish tolerance to β cells in NOD mice

A. Cooke, H. Waldmann, P. Hutchings, 1992, European journal of immunology.

The potential of hybrid antibodies secreted by hybrid‐hybridomas in tumour therapy

H. Waldmann, M. Clark, M. Clark, 1988, International journal of cancer. Supplement = Journal international du cancer. Supplement.

Properties of educated T cells. The ability of educated T cells to facilitate the immune response to non‐cross‐reacting antigens in vitro

H. Waldmann, A. Munro, P. Hunter, 1973 .

Prevention of diabetes but not insulitis in NOD mice injected with antibody to CD4.

A. Cooke, H. Waldmann, A. Hayward, 1993, Journal of autoimmunity.

Bone marrow transplantation for chronic myeloid leukemia with volunteer unrelated donors using ex vivo or in vivo T-cell depletion: major prognostic impact of HLA class I identity between donor and recipient.

J. Goldman, H. Waldmann, F. van Rhee, 1995, Blood.

L3T4 and Lyt-2 T cells are both involved in the generation of low-dose streptozotocin-induced diabetes in mice.

H. Kolb, H. Waldmann, S. Cobbold, 1987, Clinical and experimental immunology.

THERAPEUTIC POTENTIAL OF MONOCLONAL ANTIBODIES TO THE LEUKOCYTE‐COMMON ANTIGEN: SYNERGY AND INTERFERENCE IN COMPLEMENT‐MEDIATED LYSIS

G. Hale, H. Waldmann, M. Clark, 1985, Transplantation.

Limiting transplantation-related mortality following unrelated donor stem cell transplantation by using a nonmyeloablative conditioning regimen.

C. Craddock, S. Mackinnon, K. Peggs, 2002, Blood.

Ex-vivo whole blood cultures for predicting cytokine-release syndrome: dependence on target antigen and antibody isotype.

J. Isaacs, G. Hale, H. Waldmann, 1995, Therapeutic immunology.

T cell depletion of human bone marrow. Comparison of Campath-1 plus complement, anti-T cell ricin A chain immunotoxin, and soybean agglutinin alone or in combination with sheep erythrocytes or immunomagnetic beads.

H. Waldmann, B. Dupont, R. O'reilly, 1989, Transplantation.

Transplantation—caught in the crossfire!

H. Waldmann, 2002, Nature Immunology.

THE ROLE OF INHIBITORY T CELLS IN PREVENTING T-B CO-OPERATION BETWEEN HISTOINCOMPATIBLE CELLS

H. Waldmann, H. Pope, A. Munro, 1978 .

Incidence and outcome of adenovirus disease in transplant recipients after reduced-intensity conditioning with alemtuzumab.

C. Fegan, S. Mackinnon, G. Hale, 2004, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

Indirect Recognition Graft Rejection Can Operate Through Cutting Edge: Linked Suppression of Skin

F. Bemelman, H. Waldmann, S. Cobbold, 1998 .

Impact on T-cell depletion and CD34+ cell recovery using humanised CD52 monoclonal antibody (CAMPATH-1H) in BM and PSBC collections; comparison with CAMPATH-1M and CAMPATH-1G.

G. Hale, H. Waldmann, S. Brookes, 2000, Cytotherapy.

Respiratory virus infections in transplant recipients after reduced‐intensity conditioning with Campath‐1H: high incidence but low mortality

C. Fegan, S. Mackinnon, G. Hale, 2002, British journal of haematology.

Autologous transplantation with CD52 monoclonal antibody-purged marrow for acute lymphoblastic leukemia: long-term follow-up.

S. Singhal, J. Mehta, G. Hale, 1996, Leukemia & lymphoma.

In vivo use of Campath-1G to prevent graft-versus-host disease and graft rejection after bone marrow transplantation.

J. Falkenburg, R. Willemze, H. Waldmann, 1992, Bone marrow transplantation.

Alemtuzumab (Campath-1H) in allogeneic stem cell transplantation: where do we go from here?

G. Hale, H. Waldmann, S. Chakrabarti, 2004, Transplantation proceedings.

T‐cell depletion with Campath‐1H ‘in the bag’ for matched related allogeneic peripheral blood stem cell transplantation is associated with reduced graft‐versus‐host disease, rapid immune constitution and improved survival

C. Fegan, G. Hale, H. Waldmann, 2003, British journal of haematology.

Contact Between Good Friends: What Limiting Dilution Analysis Taught Us

H. Waldmann, 2005, Scandinavian journal of immunology.

The role of MHC gene products in the development of the T-cell repertoire.

H. Waldmann, P. Maurer, A. Munro, 1980, Haematology and blood transfusion.

Monogamous T helper cell

J. Phillips, H. Waldmann, 1977, Nature.

Cooperation across the histocompatibility barrier

H. Waldmann, H. Pope, H. Waldmann, 1975, Nature.

Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis.

A. Compston, J. Isaacs, A. Compston, 1996, Brain : a journal of neurology.

Generation of anti‐inflammatory adenosine byleukocytes is regulated by TGF‐β

D. Greaves, F. Regateiro, H. Waldmann, 2011, European journal of immunology.

A role for CD4+ but not CD8+ T cells in immunity to Schistosoma mansoni induced by 20 krad-irradiated and Ro 11-3128-terminated infections.

H. Waldmann, S. Cobbold, P. Crocker, 1989, Immunology.

Expansion of Foxp3+ T-cell populations by Candida albicans enhances both Th17-cell responses and fungal dissemination after intravenous challenge

H. Waldmann, N. Gow, S. Gaffen, 2014, European journal of immunology.

Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo

H. Waldmann, S. Cobbold, A. Jayasuriya, 1984, Nature.

Neutralizing TNF-alpha activity modulates T-cell phenotype and function in experimental autoimmune uveoretinitis.

A. Dick, J. Isaacs, G. Hale, 1998, Journal of autoimmunity.

Induction of classical transplantation tolerance in the adult

H. Waldmann, S. Cobbold, S. Qin, 1989, The Journal of experimental medicine.

Ex vivo T‐cell depletion with the monoclonal antibody Campath‐1 plus human complement effectively prevents acute graft‐versus‐host disease in allogeneic bone marrow transplantation

H. Heimpel, G. Hale, H. Waldmann, 1986, British journal of haematology.

Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance

H. Waldmann, S. Cobbold, S. Qin, 1986, Nature.

The Depletion of T Cell Subsets in Vitro and in Vivo

H. Waldmann, S. Cobbold, G. Martin, 1986 .

Monoclonal antibodies for the prevention of graft-versus-host disease and marrow graft rejection. The depletion of T cell subsets in vitro and in vivo.

H. Waldmann, S. Cobbold, G. Martin, 1986, Transplantation.

Neutralizing tumor necrosis factor activity leads to remission in patients with refractory noninfectious posterior uveitis.

J. Forrester, A. Dick, J. Isaacs, 2004, Archives of ophthalmology.

Morbidity and mortality in rheumatoid arthritis patients with prolonged and profound therapy-induced lymphopenia.

D. Symmons, J. Isaacs, G. Hale, 2001, Arthritis and rheumatism.

reconstitution cell transplantation: potential role of Campath-1H in delaying immune High incidence of cytomegalovirus infection after nonmyeloablative stem

C. Fegan, S. Mackinnon, K. Peggs, 2008 .

High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution.

C. Craddock, C. Fegan, S. Mackinnon, 2002, Blood.

Radiotherapy-based conditioning is effective immunosuppression for patients undergoing transplantation with T-cell depleted stem cell grafts for severe aplasia.

G. Hale, H. Waldmann, N. Novitzky, 2004, Cytotherapy.

The window of therapeutic opportunity in multiple sclerosis

H. Waldmann, S. Seaman, A. Coles, 2005, Journal of Neurology.

T‐cell‐depleted allogeneic bone marrow transplantation for acute leukaemia using Campath‐1 antibodies and post‐transplant administration of donor's peripheral blood lymphocytes for prevention of relapse

S. Steinberg, A. Nagler, G. Hale, 1995, British journal of haematology.

Regulatory T cells in transplantation tolerance.

H. Waldmann, S. Cobbold, L. Graça, 2005, Current topics in microbiology and immunology.

Identification of Regulatory T Cells in Tolerated Allografts

H. Waldmann, S. Cobbold, L. Graça, 2002, The Journal of experimental medicine.

Alemtuzumab (CAMPATH 1H) Induction Therapy in Cadaveric Kidney Transplantation—Efficacy and Safety at Five Years

Kenneth G. C. Smith, J. Bradley, P. Friend, 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

REMISSION INDUCTION IN NON-HODGKIN LYMPHOMA WITH RESHAPED HUMAN MONOCLONAL ANTIBODY CAMPATH-1H

H. Waldmann, J. Phillips, R. Marcus, 1988, The Lancet.

Reshaping human antibodies for therapy

Lutz Riechmann, Herman Waldmann, G. Winter, 1988, Nature.

Limiting Dilution Analysis of Cells in the Immune System

H. Waldmann, I. Lefkovits, 1980 .

Anti-adhesion molecule therapy as an interventional strategy for autoimmune inflammation.

G. Hale, H. Waldmann, C. Lockwood, 1999, Clinical immunology.

Dickkopf-3, a Tissue-Derived Modulator of Local T-Cell Responses

Kathy O. Lui, Maria Papatriantafyllou, M. Meister, 2015, Front. Immunol..

T Cell-dependent Mediator in the Immune Response

H. Waldmann, H. Waldmann, A. Munro, 1973, Nature.

PREVENTION OF GRAFT-VERSUS-HOST DISEASE IN ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR LEUKEMIA BY T-CELL DEPLETION INVITRO PRIOR TO TRANSPLANTATION

J. Michaeli, E. Galun, G. Hale, 1985 .

In vivo transfer of GPI-linked complement restriction factors from erythrocytes to the endothelium.

J. Platt, H. Waldmann, T. Coffman, 1995, Science.

THE ANTIBODY PROBLEM AND THE GENERATION OF MONOCLONAL ANTIBODIES

H. Waldmann, C. Milstein, 2011 .

Direct antibody rosette-forming reactions using monoclonal markers of lymphocyte subpopulations. Methodology and applications illustrated by investigations with rat pan-T antibodies of the CAMPATH series.

H. Waldmann, R. Coombs, A. B. Wilson, 1986, Journal of immunological methods.

Bone marrow transplantation for patients with chronic myeloid leukemia.

R. Marcus, D. Catovsky, J. Goldman, 1986, The New England journal of medicine.

TGF-β in transplantation tolerance.

F. Regateiro, H. Waldmann, S. Cobbold, 2011, Current opinion in immunology.

monoclonal antibodies Separation of hemopoietic cells from adult mouse marrow by use of

H. Waldmann, S. Cobbold, S. Watt, 2011 .

Delay in onset of insulitis in NOD mice following a single injection of CD 4 and CD 8 antibodies.

A. Cooke, H. Waldmann, S. Cobbold, 1988, Journal of autoimmunity.

Mechanisms of antibody immunotherapy on clonal islet reactive T cells.

D. Roelen, J. Medema, G. Hale, 2006, Human immunology.

Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes.

Michel Goldman, Markus Walter, Herman Waldmann, 2005, The New England journal of medicine.

CD4 monoclonal antibody pairs for immunosuppression and tolerance induction

H. Waldmann, S. Cobbold, H. Tighe, 1987, European journal of immunology.

A noncomitogenic CD2R monoclonal antibody induces apoptosis of activated T cells by a CD95/CD95-L-dependent pathway.

H. Waldmann, G. Bismuth, S. Fournel, 1998, Journal of immunology.

Fas-independent apoptosis of activated T cells induced by antibodies to the HLA class I alpha1 domain.

J. Banchereau, V. Engelhard, H. Waldmann, 1997, Blood.

Depletion of L3T4+ and Lyt-2+ cells by rat monoclonal antibodies alters the development of adoptively transferred experimental autoimmune thyroiditis.

H. Waldmann, S. Cobbold, Y. Kong, 1989, Cellular immunology.

The Role of Lipid Metabolism in T Lymphocyte Differentiation and Survival

H. Waldmann, S. Cobbold, A. ten Bokum, 2018, Front. Immunol..

Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice.

J. Cyster, H. Waldmann, T. Honda, 2010, The Journal of clinical investigation.

The immunogenicity of chimeric antibodies

M. Neuberger, M. Brüggemann, G. Winter, 1989, The Journal of experimental medicine.

"Infectious" transplantation tolerance

D. Kioussis, J. Elliott, H. Waldmann, 1993, Science.

Secreted and Transmembrane 1A Is a Novel Co-Stimulatory Ligand

H. Waldmann, Marion H. Brown, D. Howie, 2013, PloS one.

The failure to show a necessary role for C3 in the in vitro antibody response

H. Waldmann, P. Lachmann, H. Waldmann, 1975, European journal of immunology.

Linked suppression of skin graft rejection can operate through indirect recognition.

F. Bemelman, H. Waldmann, S. Cobbold, 1998, Journal of immunology.

T cell suppression in transplantation tolerance through linked recognition.

H. Waldmann, S. Cobbold, A. Mellor, 1996, Journal of immunology.

CD8+ T‐Cell Depletion and Rapamycin Synergize with Combined Coreceptor/Stimulation Blockade to Induce Robust Limb Allograft Tolerance in Mice

F. Schuind, M. Goldman, H. Waldmann, 2008, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

CAMPATH‐1 monoclonal antibody therapy in severe refractory autoimmune thrombocytopenic purpura

H. Waldmann, R. E. Marcus, G. Hale, 1993, British journal of haematology.

THE REPOPULATION CAPACITY OF BONE MARROW GRAFTS FOLLOWING PRETREATMENT WITH MONOCLONAL ANTIBODIES AGAINST T LYMPHOCYTES IN RHESUS MONKEYS

G. Hale, H. Waldmann, G. Wagemaker, 1988, Transplantation.

Humanised monoclonal antibody therapy for rheumatoid arthritis

J. Isaacs, M. Keogan, G. Hale, 1992, The Lancet.

Low dose unresponsiveness with a thymus independent antigen

H. Waldmann, H. Pope, 1975, Nature.

Selective isolation of murine erythropoietin-responsive progenitor cells (CFU-E) with monoclonal antibodies.

H. Waldmann, S. Watt, D. Gilmore, 1983, Molecular biology & medicine.

Embryonic stem cells: overcoming the immunological barriers to cell replacement therapy.

Kathy O. Lui, H. Waldmann, K. O. Lui, 2009, Current stem cell research & therapy.

Generation of immunogenic dendritic cells from human embryonic stem cells without serum and feeder cells.

H. Waldmann, J. Lebkowski, P. Fairchild, 2009, Regenerative medicine.

Directed differentiation of dendritic cells from mouse embryonic stem cells

H. Waldmann, H. Waldmann, L. Graça, 2000, Current Biology.

Campath IH allows low-dose cyclosporine monotherapy in 31 cadaveric renal allograft recipients.

J. Bradley, P. Friend, G. Hale, 1999, Transplantation.

Limiting dilution analysis of the cells of immune system I. The clonal basis of the immune response.

I Lefkovits, H. Waldmann, I. Lefkovits, 1984, Immunology today.

Regulatory T Cells Overexpress a Subset of Th2 Gene Transcripts1

D. Zélénika, H. Waldmann, S. Cobbold, 2002, The Journal of Immunology.

Suppression in murine experimental autoimmune thyroiditis: in vivo inhibition of CD4+ T cell-mediated resistance by a nondepleting rat CD4 monoclonal antibody.

H. Waldmann, S. Cobbold, G. Nabozny, 1991, Cellular immunology.

Resistance to experimental autoimmune thyroiditis: L3T4+ cells as mediators of both thyroglobulin-activated and TSH-induced suppression.

H. Waldmann, S. Cobbold, Y. Kong, 1989, Clinical immunology and immunopathology.

Allosuppression: evidence for the involvement of both “noncytotoxic” and cytotoxic T cells

H. Waldmann, R. Zamoyska, 1984, European journal of immunology.

Regulatory T cells and transplantation tolerance: Emerging from the darkness?

H. Waldmann, 2021, European journal of immunology.

Mechanisms of immunological tolerance.

H. Waldmann, 2016, Clinical biochemistry.

Tolerance: an overview and perspectives

H. Waldmann, 2010, Nature Reviews Nephrology.

Regulatory T cells: context matters.

H. Waldmann, S. Cobbold, 2009, Immunity.

How do monoclonal antibodies induce tolerance? A role for infectious tolerance?

H. Waldmann, S. Cobbold, Herman Waldmann, 1998, Annual review of immunology.

Depletion of CD4+ and CD8+ cells eliminates immunologic memory of thyroiditogenicity in murine experimental autoimmune thyroiditis.

H. Waldmann, S. Cobbold, Y. Kong, 1994, Autoimmunity.

Pathogenic mechanisms in murine autoimmune thyroiditis: short- and long-term effects of in vivo depletion of CD4+ and CD8+ cells.

H. Waldmann, S. Cobbold, Y. Kong, 1989, Clinical and experimental immunology.

Regulating the immune response to transplants. a role for CD4+ regulatory cells?

H. Waldmann, S. Cobbold, 2001, Immunity.

Monoclonal antibodies for the induction of transplantation tolerance.

H. Waldmann, S. Cobbold, 1993, Current opinion in immunology.

Control of immune-mediated disease of the central nervous system with monoclonal (CD4-specific) antibodies

H. Waldmann, D. Baker, A. Davison, 1993, Journal of Neuroimmunology.

How many T cells help one B cell?

J. Phillips, H. Waldmann, 1980, Springer Seminars in Immunopathology.

T cell dependence of B cell unresponsiveness in vitro

H. Waldmann, A. Munro, 1974, European journal of immunology.

INSITU ANALYSIS OF THYROID T-CELL INFILTRATES IN MURINE EXPERIMENTAL AUTOIMMUNE-THYROIDITIS (EAT)

H. Waldmann, S. Cobbold, Y. Kong, 1987 .

ADOPTIVE SUPPRESSION OF ERYTHROCYTE RECIPIENTS AUTOANTIBODIES IN Lyt-2' DEPLETED

H. Waldmann, 1989 .

Adoptive suppression of erythrocyte autoantibodies in Lyt-2+ depleted recipients.

H. Waldmann, S. Cobbold, M. Day, 1989, Autoimmunity.

Stability of tolerance in mice generated by CD4 and CD8 monoclonal antibody treatment: cell transfer experiments.

S. Metcalfe, H. Waldmann, S. Cobbold, 1993, Transplantation proceedings.

Embryonic stem cells: protecting pluripotency from alloreactivity.

H. Waldmann, N. Robertson, P. Fairchild, 2007, Current opinion in immunology.

Rejection of H-Y disparate skin grafts by monospecific CD4+ Th1 and Th2 cells: no requirement for CD8+ T cells or B cells.

D. Zélénika, H. Waldmann, S. Cobbold, 1998, Journal of immunology.

Identification of macrophages and smooth muscle cells in human atherosclerosis using monoclonal antibodies

H. Waldmann, M. J. Mitchinson, H. Waldmann, 1985, The Journal of pathology.

Engraftment of marrow allografts treated with Campath-1 monoclonal antibodies.

A. Nagler, G. Hale, H. Waldmann, 1999, Experimental hematology.

Co-receptor and co-stimulation blockade for mixed chimerism and tolerance without myelosuppressive conditioning

H. Waldmann, S. Cobbold, L. Graça, 2006, BMC Immunology.

The plasticity and stability of regulatory T cells

Shimon Sakaguchi, Herman Waldmann, Dario A. A. Vignali, 2013, Nature Reviews Immunology.

Foxp3 Expression Is Required for the Induction of Therapeutic Tissue Tolerance

A. G. Betz, F. Regateiro, H. Waldmann, 2012, The Journal of Immunology.

Dominant transplantation tolerance impairs CD8+ T cell function but not expansion

H. Waldmann, S. Cobbold, L. Graça, 2002, Nature Immunology.

Both CD4+CD25+ and CD4+CD25− Regulatory Cells Mediate Dominant Transplantation Tolerance1

H. Waldmann, S. Cobbold, L. Graça, 2002, The Journal of Immunology.

Critical Influence of Natural Regulatory CD25+ T Cells on the Fate of Allografts in the Absence of Immunosuppression

M. Goldman, H. Waldmann, L. Graça, 2005, Transplantation.

Regulatory T cells and dendritic cells in transplantation tolerance: molecular markers and mechanisms

D. Zélénika, H. Waldmann, S. Cobbold, 2003, Immunological reviews.

Successful haploidentical mismatched bone marrow transplantation in severe combined immunodeficiency: T cell removal using CAMPATH‐I monoclonal antibody and E‐rosetting

G. Morgan, G. Hale, H. Waldmann, 1986, British journal of haematology.

CAMPATH-1 monoclonal antibodies in bone marrow transplantation.

G. Hale, H. Waldmann, Geoff Hale, 1994, Journal of hematotherapy.

Recent results using CAMPATH-1 antibodies to control GVHD and graft rejection.

G. Hale, H. Waldmann, 1996, Bone marrow transplantation.

Control of graft-versus-host disease and graft rejection by T cell depletion of donor and recipient with Campath-1 antibodies. Results of matched sibling transplants for malignant diseases.

G. Hale, H. Waldmann, Geoff Hale, 1994, Bone marrow transplantation.

Improving the outcome of bone marrow transplantation by using CD52 monoclonal antibodies to prevent graft-versus-host disease and graft rejection.

M. Horowitz, G. Hale, H. Waldmann, 1998, Blood.

Transplantation Tolerance Regulatory Cells Mediate Dominant - CD25 + and CD4 + CD25 + Both CD4

H. Waldmann, S. Cobbold, L. Graça, 2010 .

A Key Role for TGF-β Signaling to T Cells in the Long-Term Acceptance of Allografts1

H. Waldmann, Jianbo Ma, S. Cobbold, 2007, The Journal of Immunology.

CAMPATH-1 antibodies in stem-cell transplantation.

S. Mackinnon, G. Hale, H. Waldmann, 2001, Cytotherapy.

CAMPATH: from concept to clinic

G. Hale, H. Waldmann, 2005, Philosophical Transactions of the Royal Society B: Biological Sciences.

Alemtuzumab (Campath-1H) for treatment of lymphoid malignancies in the age of nonmyeloablative conditioning?

S. Mackinnon, G. Hale, H. Waldmann, 2002, Bone Marrow Transplantation.

Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells

Manching Ku, J. C. Tsang, H. Waldmann, 2018, Genome Medicine.

Campath-1 Abs 'in the bag' for hematological malignancies: the Cape Town experience.

H. Waldmann, G. Hale, N. Novitzky, 2004, Cytotherapy.

Development and clinical use of CAMPATH® 1H

H. Waldmann, 2003 .

Immune reconstitution at 6 months following t-cell depleted hematopoietic stem cell transplantation is predictive for treatment outcome

G. Hale, H. Waldmann, G. Davison, 2002, Transplantation.

nonmyeloablative stem cell transplantation In vivo CAMPATH-1H prevents graft-versus-host disease following

G. Morgan, S. Mackinnon, K. Peggs, 2013 .

Regulatory T cells in the induction and maintenance of peripheral transplantation tolerance

H. Waldmann, S. Cobbold, L. Graça, 2003, Transplant international : official journal of the European Society for Organ Transplantation.

Epstein-Barr virus (EBV) associated B-cell lymphoproliferative disease following HLA identical sibling marrow transplantation for aplastic anaemia in a patient with an EBV seronegative donor.

G. Hale, H. Waldmann, D. Crawford, 1999, Transplantation.

Preliminary experience of allogeneic stem cell transplantation for lymphoproliferative disorders using BEAM–CAMPATH conditioning: an effective regimen with low procedure‐related toxicity

N. Russell, J. Byrne, N. Russell, 2000, British journal of haematology.

The molecular mechanisms of regulatoryT cell immunosuppression

Kendall A. Smith, P. Pandiyan, H. Waldmann, 2011 .

Manipulation of T-cell responses with monoclonal antibodies.

H. Waldmann, H. Waldmann, 1989, Annual review of immunology.

Lymphocyte homeostasis following therapeutic lymphocyte depletion in multiple sclerosis

Amanda L. Cox, A. Coles, G. Hale, 2005, European journal of immunology.

Therapeutic immunosuppression of T cells.

J. Isaacs, H. Waldmann, S. Cobbold, 1992, Current opinion in biotechnology.

Limiting dilution analysis of cells of the immune system II: What can be learnt?

H. Waldmann, I. Lefkovits, 1984, Immunology today.

S. Mackinnon, N. Cross, H. Waldmann, 1993, Bone marrow transplantation.

The characterisation of monoclonal antibodies against haemopoietic cells: comparison of an immunoperoxidase method with fluorescence activated cell sorting.

H. Waldmann, D. Swirsky, S. Watt, 1983, Journal of immunological methods.

Bone marrow transplantation in beta-thalassemia major with prevention of graft-vs-host disease.

G. Hale, H. Waldmann, C. Brautbar, 1988, Birth defects original article series.

Reduced incidence of GVHD in recipients of t-cell depleted marrow

J. Goldman, H. Waldmann, J. Apperley, 1986 .

Antilymphocytic antibodies and marrow transplantation. VII. Two of nine monoclonal anti-Thy-1 antibodies used for pretreatment of donor marrow suppressed graft-versus-host reactions without added complement.

H. Waldmann, S. Cobbold, S. Thierfelder, 1985, Experimental hematology.

Strain variation in susceptibility to monoclonal antibody-induced transplantation tolerance.

H. Waldmann, S. Cobbold, J. Davies, 1997, Transplantation.

INFLUENCE OF ISOTYPE ON SUPPRESSION OF GVH WITH ANTI-TH-1

H. Waldmann, S. Cobbold, S. Thierfelder, 1984 .

Mechanism of recovery from acute virus infection: treatment of lymphocytic choriomeningitis virus-infected mice with monoclonal antibodies reveals that Lyt-2+ T lymphocytes mediate clearance of virus and regulate the antiviral antibody response

D. Moskophidis, H. Waldmann, S. Cobbold, 1987, Journal of virology.

Resistance of regulatory T cells to glucocorticoid‐viduced TNFR family‐related protein (GITR) during Plasmodium yoelii infection

H. Waldmann, T. Imai, H. Hisaeda, 2005 .

Loss of the TGFβ-Activating Integrin αvβ8 on Dendritic Cells Protects Mice from Chronic Intestinal Parasitic Infection via Control of Type 2 Immunity

H. Waldmann, T. Sparwasser, R. Grencis, 2013, PLoS pathogens.

A Novel Strategy To Reduce the Immunogenicity of Biological Therapies

A. Compston, A. Coles, G. Hale, 2010, The Journal of Immunology.

T cell-dependent mediator in the immune response. II. Physical and biological properties.

H. Waldmann, A. Munro, 1974, Immunology.

Dominant tolerance: activation thresholds for peripheral generation of regulatory T cells.

H. Waldmann, S. Cobbold, L. Graça, 2005, Trends in immunology.

Embryonic stem cells and the challenge of transplantation tolerance.

H. Waldmann, K. F. Nolan, P. Fairchild, 2004, Trends in immunology.

CD73 and adenosine generation in the creation of regulatory microenvironments

F. Regateiro, H. Waldmann, S. Cobbold, 2013, Clinical and experimental immunology.

Crystal structures of a rat anti-CD52 (CAMPATH-1) therapeutic antibody Fab fragment and its humanized counterpart.

G. Cheetham, A. Bloomer, G. Hale, 1998, Journal of molecular biology.

Partial and transient modulation of the CD3–T‐cell receptor complex, elicited by low‐dose regimens of monoclonal anti‐CD3, is sufficient to induce disease remission in non‐obese diabetic mice

H. Waldmann, M. Rosenzweig, D. Mehta, 2010, Immunology.

CD40 ligand blockade induces CD4+ T cell tolerance and linked suppression.

H. Waldmann, S. Cobbold, K. Honey, 1999, Journal of immunology.

Th17 Cells Induce a Distinct Graft Rejection Response That Does Not Require IL‐17A

F. Regateiro, H. Waldmann, S. Cobbold, 2012, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Limiting dilution analysis of helper T-cell function.

H. Waldmann, I. Lefkovits, J. Quintáns, 1975, Immunology.

Elimination of the immunogenicity of therapeutic antibodies.

D. Kioussis, G. Hale, H. Waldmann, 1999, Journal of immunology.

Elimination of the Immunogenicity of Therapeutic Antibodies 1

D. Kioussis, G. Hale, H. Waldmann, 1999 .

Regulatory T cells in transplantation.

H. Waldmann, S. Cobbold, L. Graça, 2006, Seminars in immunology.

Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells

H. Waldmann, S. Cobbold, E. Adams, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Foxp3 drives oxidative phosphorylation and protection from lipotoxicity.

A. G. Betz, H. Waldmann, S. Cobbold, 2017, JCI insight.

Harnessing FOXP3+ regulatory T cells for transplantation tolerance.

H. Waldmann, S. Cobbold, D. Howie, 2014, The Journal of clinical investigation.

Correction: Secreted and Transmembrane 1A Is a Novel Co-Stimulatory Ligand

H. Waldmann, Marion H. Brown, D. Howie, 2013, PLoS ONE.

Tolerance and Linked Suppression CD40 Ligand Blockade Induces CD4+ T Cell

H. Waldmann, S. Cobbold, K. Honey, 2013 .

The relationship between pityriasis rubra pilaris and inflammatory arthritis: case report and response of the arthritis to anti-tumor necrosis factor immunotherapy.

P. Emery, J. Isaacs, P. Conaghan, 1999, Arthritis and rheumatism.

Human CD59 expressed in transgenic mouse hearts inhibits the activation of complement.

J. Platt, H. Waldmann, K. McCurry, 1995, Transplant immunology.

Morbidity and mortality in rheumatoid arthritis patients with prolonged therapy-induced lymphopenia: twelve-year outcomes.

D. Symmons, J. Isaacs, G. Hale, 2008, Arthritis and rheumatism.

Mechanisms of Peripheral Tolerance and Suppression Induced by Monoclonal Antibodies to CD4 and CD8

H. Waldmann, S. Cobbold, E. Adams, 1996, Immunological reviews.

Expression of murine IL-12 is regulated by translational control of the p35 subunit.

H. Waldmann, E. Adams, P. Fairchild, 1999, Journal of immunology.

IL-10-Conditioned Dendritic Cells, Decommissioned for Recruitment of Adaptive Immunity, Elicit Innate Inflammatory Gene Products in Response to Danger Signals1

Ruth Croxton, Herman Waldmann, H. Waldmann, 2004, The Journal of Immunology.

Structural basis for ligand-mediated mouse GITR activation

J. Lear, Xiaomin Song, K. Furuuchi, 2008, Proceedings of the National Academy of Sciences.

T cell depletion by exposure to Campath-1G in vitro prevents graft-versus-host disease.

H. Waldmann, L. Fullard, G. Hale, 1994, Bone marrow transplantation.

Sequence of a rat immunoglobulin y2c heavy chain constant region cDNA: extensive homology to mouse y3

H. Waldmann, F. Calabi, M. Bruggemann, 1988 .

Ex vivo depletion of T cells from bone marrow grafts with CAMPATH-1 in acute leukemia: graft-versus-host disease and graft-versus-leukemia effect.

G. Hale, H. Waldmann, G. Hale, 1999, Transplantation.

Preservation of recall immunity in anti‐CD3‐treated recent onset type 1 diabetes patients

C. Mathieu, H. Waldmann, D. Pipeleers, 2011, Diabetes/metabolism research and reviews.

CAMPATH-1H in multiple sclerosis

A. Compston, A. Coles, G. Hale, 1996, Multiple sclerosis.

Preliminary evidence from magnetic resonance imaging for reduction in disease activity after lymphocyte depletion in multiple sclerosis

A. Compston, A. Compston, G. Hale, 1994, The Lancet.

1.9 A structure of the therapeutic antibody CAMPATH-1H fab in complex with a synthetic peptide antigen.

L. James, A. Bloomer, G. Hale, 1999, Journal of molecular biology.

malignancies: influence of antibody isotype Effects of CAMPATH-1 antibodies in vivo in patients with lymphoid

G. Hale, H. Waldmann, M. Dyer, 2011 .

CD4 and CD8 monoclonal antibody therapy: Strategies to prolong renal allograft survival in the dog

H. Waldmann, C. Watson, H. Davies, 1993, The British journal of surgery.

CD8+ Lymphocytes Do Not Mediate Protection against Acute Superinfection 20 Days after Vaccination with a Live Attenuated Simian Immunodeficiency Virus

G. Hale, H. Waldmann, R. Stebbings, 2005, Journal of Virology.

CD 8 Lymphocytes Do Not Mediate Protection against Acute Superinfection 20 Days after Vaccination with a Live Attenuated Simian Immunodeficiency Virus

G. Hale, H. Waldmann, R. Stebbings, 2005 .

Cutting Edge: Anti-CD154 Therapeutic Antibodies Induce Infectious Transplantation Tolerance1

H. Waldmann, S. Cobbold, L. Graça, 2000, The Journal of Immunology.

Regulation of CD40 function by its isoforms generated through alternative splicing.

H. Waldmann, P. Fairchild, Y. Tone, 2001, Proceedings of the National Academy of Sciences of the United States of America.

T-cell killing of target cells induced by hybrid antibodies: comparison of two bispecific monoclonal antibodies.

H. Waldmann, M. Clark, 1987, Journal of the National Cancer Institute.

Reprogramming the immune system using antibodies.

H. Waldmann, L. Graça, 2006, Methods in molecular biology.

Dominant transplantation tolerance. Opinion.

H. Waldmann, S. Cobbold, L. Graça, 2003, Current opinion in immunology.

Gene structure of human CD59 and demonstration that discrete mRNAs are generated by alternative polyadenylation.

H. Waldmann, M. Tone, L. Walsh, 1992, Journal of molecular biology.

Requirement for CD 8 Th 1 and Th 2 Cells : No + Monospecific CD 4 Rejection of HY Disparate Skin Grafts by Waldmann and

D. Zélénika, H. Waldmann, S. Cobbold, 1998 .

Characterization of effector cells of graft vs leukemia following allogeneic bone marrow transplantation in mice inoculated with murine B-cell leukemia

H. Waldmann, S. Cobbold, S. Slavin, 2005, Cancer Immunology and Immunotherapy.

High dose bone marrow transplantation induces deletion of antigen-specific T cells in a Fas-independent manner.

F. Bemelman, H. Waldmann, S. Cobbold, 2000, Transplantation.

Non-Invasive Multiphoton Imaging of Islets Transplanted Into the Pinna of the NOD Mouse Ear Reveals the Immediate Effect of Anti-CD3 Treatment in Autoimmune Diabetes

K. Okkenhaug, M. Clatworthy, A. Cooke, 2018, Front. Immunol..

Anti-globulin responses to rat and humanized CAMPATH-1 monoclonal antibody used to treat transplant rejection.

P. Friend, G. Hale, P. Rebello, 1999, Transplantation.

Dominant tolerance and linked suppression induced by therapeutic antibodies do not depend on Fas-FasL interactions.

H. Waldmann, S. Cobbold, K. Honey, 2000, Transplantation.

Campath-1G in vivo confers a low incidence of graft-versus-host disease associated with a high incidence of mixed chimaerism after bone marrow transplantation for severe aplastic anaemia using HLA-identical sibling donors.

G. Hale, H. Waldmann, E. Davies, 1996, Bone marrow transplantation.

Tolerance and suppression in a primed immune system.

J. Phillips, H. Waldmann, S. Cobbold, 1996, Transplantation.

Prophylactic use of an antilymphocyte monoclonal antibody following renal transplantation: a randomized controlled trial.

S. Gore, P. Friend, G. Hale, 1987, Transplantation proceedings.

Tmem176B and Tmem176A are associated with the immature state of dendritic cells

Herman Waldmann, H. Waldmann, S. Cobbold, 2010, Journal of leukocyte biology.

T cell regulation in adult transplantation tolerance.

J. Phillips, H. Waldmann, S. Cobbold, 1996, Journal of immunology.

Antigen-non-specific T-cell factor in B-cell activation. Origin, biological properties and failure to show a relationship to H-2.

H. Waldmann, C. Desaymard, P. Poulton, 1976, Immunology.

Regulation and privilege in transplantation

H. Waldmann, 2007 .

Beneficial effect of monoclonal antibody to interleukin 2 receptor on activated T cells in rheumatoid arthritis.

H. Waldmann, V. Kyle, B. Hazleman, 1989, Annals of the rheumatic diseases.

Inflammation, Demyelination, and Axonal Degeneration: Three Aspects of the Pathogenesis of Multiple Sclerosis Revealed by Campath-1H Treatment

A. Compston, P. Molyneux, A. Coles, 2004 .

A repertoire of monoclonal antibodies with human heavy chains from transgenic mice.

M. Surani, M. Neuberger, M. Brüggemann, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Immunology: Protection and privilege

H. Waldmann, 2006, Nature.

Erythroid-specific expression of human CD59 and transfer to vascular endothelial cells.

J. Platt, H. Waldmann, T. Coffman, 1994, Transplantation proceedings.

Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose.

F. Bemelman, H. Waldmann, S. Cobbold, 1998, Journal of immunology.

Anti‐CD3 treatment up‐regulates programmed cell death protein‐1 expression on activated effector T cells and severely impairs their inflammatory capacity

A. Cooke, J. Phillips, F. Wong, 2017, Immunology.

Reversal of allograft rejection using the monoclonal antibody, Campath-1G.

P. Friend, G. Hale, P. Rebello, 1991, Transplantation proceedings.

Combination therapy with a TNF antagonist and a CD4 monoclonal antibody in rheumatoid arthritis. A pilot study.

P. Emery, J. Isaacs, A. Morgan, 1997 .

Skin allograft rejection by L3/T4+ and Lyt-2+ T cell subsets.

H. Waldmann, S. Cobbold, 1986, Transplantation.

Distribution of protectin (CD59), a complement membrane attack inhibitor, in normal human tissues.

S. Meri, H. Waldmann, H Waldmann, 1991, Laboratory investigation; a journal of technical methods and pathology.

Removal of T cells from bone marrow for transplantation. Comparison of rat monoclonal anti-lymphocyte antibodies of different isotypes.

T. Hoang, G. Hale, H. Waldmann, 1983, Molecular biology & medicine.

TransplantationAntibodies Induce Infectious Cutting Edge : Anti-CD 154 Therapeutic Cobbold and

H. Waldmann, L. Graça, K. Honey, 2000 .

CD40 Ligand Blockade Induces CD4

H. Waldmann, S. Cobbold, K. Honey, 1999 .

Special regulatory T cell review: The suppression problem!

H. Waldmann, 2008, Immunology.

Differences in calcium requirements for B-cell tolerance and immunity.

H. Waldmann, R. Shinton, C. Desaymard, 1980, Immunology.

Probing dendritic cell function by guiding the differentiation of embryonic stem cells.

H. Waldmann, K. F. Nolan, P. Fairchild, 2003, Methods in enzymology.

The new immunosuppression: intervention at the dendritic cell-T-cell interface.

H. Waldmann, S. Yates, A. Paterson, 2005, Current drug targets. Immune, endocrine and metabolic disorders.

Non-myeloablative transplantation for patients with Hodgkin's disease: Limited transplant related mortality and possible evidence of a graft versus Hodgkin's effect.

C. Craddock, S. Mackinnon, A. Hunter, 2001 .

Esophageal webs.

H. Waldmann, A. Turnbull, 1957, The American journal of roentgenology, radium therapy, and nuclear medicine.

Plastic T Cells: Recycling Effector Functions?

H. Waldmann, S. Cobbold, E. Agorogiannis, 2011 .

Heterogeneity of B cells reacting with T-cell factors. Evidence for matching T-cell and B-cell subsets.

H. Waldmann, I. Lefkovits, 1976, Immunology.

Stable lines of genetically modified dendritic cells from mouse embryonic stem cells

H. Waldmann, L. Graça, K. F. Nolan, 2003, Transplantation.

Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass

C. Mathieu, L. Chatenoud, H. Waldmann, 2010, Diabetologia.

Reshaping a therapeutic CD4 antibody.

H. Waldmann, S. Cobbold, M. Clark, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Synergistic complement lysis by monoclonal antibodies to the human leukocyte common antigen requires both the classical and alternative pathways.

G. Hale, H. Waldmann, B. Gorick, 1987, Molecular immunology.

Tolerance induction to human stem cell transplants with extension to their differentiated progeny

S. Ng, K. Chien, H. Waldmann, 2014, Nature Communications.

Evidence for the inactivation of precursor B cells in high dose unresponsiveness

H. Waldmann, C. Desaymard, 1976, Nature.

Can B-cell tolerance be induced by oligovalent thymus dependent antigens?

H. Waldmann, H. Pope, 1977, Immunology.

CAMPATH-1H exposes three mechanisms underlying the natural history of multiple sclerosis in the individual patient

A. Coles, H. Waldmann, D. Compston, 1998, Journal of Neuroimmunology.

THE EFFECT OF AGLYCOSYLATION ON THE IMMUNOGENICITY OF A HUMANIZED THERAPEUTIC CD3 MONOCLONAL ANTIBODY

H. Waldmann, E. Routledge, I. Lloyd, 1995, Transplantation.

Specificity of monoclonal antibody Campath-1.

H. Waldmann, G. Hale, M. Dyer, 1988, Bone marrow transplantation.

Isolation and expression of cDNA encoding the canine CD4 and CD8α antigens

H. Waldmann, S. Cobbold, D. Gorman, 1994 .

T cell-dependent mediator and B-cell clones.

H. Waldmann, I. Lefkovits, J. Quintáns, 1975, Immunology.

T cell-dependent mediator in the immune response. III. The role of non-specific factor (NSF) in the in vitro immune response.

H. Waldmann, 1975, Immunology.

Limiting Dilution Analysis ofHelper T-cell Function

H. Waldmann, I. LEFKOVITSt, 1975 .

Development and Clinical Experience with Humanised Monoclonal Antibodies

H. Waldmann, M. Clark, G. Hale, 1990 .

Sparing of first dose effect of monovalent anti-CD3 antibody used in allograft rejection is associated with diminished release of pro-inflammatory cytokines.

L. Chatenoud, H. Waldmann, S. Sacks, 1994, Therapeutic immunology.

Antibody immunogenicity: does bioprocessing hold all the answers?

H. Waldmann, 2015 .

THERAPY WITH HYBRID ANTIBODIES

H. Waldmann, M. Clark, 1989 .

Herman Waldmann, FRS, FRCP, FMEDSci: Emeritus Professor of Pathology, Sir William Dunn School of Pathology, University of Oxford, United Kingdom.

H. Waldmann, 2018, Transplantation.

Reprogramming the immune system for tolerance with monoclonal antibodies.

H. Waldmann, S. Cobbold, S. Qin, 1990, Seminars in immunology.

CD 4 and CD 8 monoclonal antibody therapy in canine renal allografts

S. Metcalfe, H. Waldmann, S. Cobbold, 1994, Transplant international : official journal of the European Society for Organ Transplantation.

Resistance of regulatory T cells to glucocorticoid-induced [corrected] TNFR family-related protein (GITR) during Plasmodium yoelii infection.

H. Waldmann, T. Imai, H. Hisaeda, 2005, European journal of immunology.

DELAYED ALLOGRAFT REJECTION IN PRIMATES TREATED WITH ANTI‐IL-2 RECEPTOR MONOCLONAL ANTIBODY CAMPATH‐6

P. Friend, S. Thiru, H. Waldmann, 1988, Transplantation.

INTERACTION OF MONOCLONAL-ANTIBODIES WITH THE IMMUNE-SYSTEM

H. Waldmann, S. Cobbold, H. Tighe, 1986 .

Regulation of the immune response.

M. Greene, H. Waldmann, 2010, Current opinion in immunology.

Cell- and tissue-specific expression of a human CD59 minigene in transgenic mice.

J. Platt, H. Waldmann, M. Tone, 1994, Transplantation Proceedings.

CAMPATH 1H (ALEMTUZUMAB) IN RENAL TRANSPLANTATION: 5-YEAR COMPARATIVE FOLLOW UP.

J. Bradley, J. Bradley, P. Friend, 2004 .

Tolerogenicity is not an absolute property of a dendritic cell

H. Waldmann, S. Cobbold, N. Saunders, 2010 .

Regulatory cells and transplantation tolerance.

H. Waldmann, S. Cobbold, 2013, Cold Spring Harbor perspectives in medicine.

Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.

H. Waldmann, S. Hori, H. Fehling, 2012, Immunity.

Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells

Kathy O. Lui, Manching Ku, J. C. Tsang, 2018, Genome Medicine.

Phase II study of subcutaneous alemtuzumab (Campath-1H) therapy of patients with previously untreated chronic lymphocytic leukemia (CLL).

E. Kimby, H. Waldmann, M. Björkholm, 2001 .

A novel role for Glucocorticoid-Induced TNF Receptor Ligand (Gitrl) in early embryonic zebrafish development.

C. Anastasaki, H. Waldmann, K. F. Nolan, 2010, The International journal of developmental biology.

Brief Definitive Report Identification of Regulatory T Cells in Tolerated Allografts

H. Waldmann, S. Cobbold, L. Graça, 2022 .

Treatment of refractory Wegener's granulomatosis with humanized monoclonal antibodies.

S. Stewart, J. Isaacs, S. Thiru, 1996, QJM : monthly journal of the Association of Physicians.

Long term results of reduced intensity transplantation in multiply relapsed and refractory Hodgkin's lymphoma: Evidence of a therapeutically relevant graft-versus-lymphoma effect.

C. Craddock, S. Mackinnon, A. Hunter, 2003 .

INVITRO TREATMENT OF MARROW WITH ATCG OR CAMPATH-1 FOR PROPHYLAXIS OF GVHD - RESULTS OF THE AG-KMT MUNCHEN

W. Wilmanns, H. Waldmann, S. Thierfelder, 1985 .

A step closer to effective transplant tolerance?

J. Bluestone, H. Waldmann, L. Turka, 2012, Nature Medicine.

The vaccinia virus C12L protein inhibits mouse IL-18 and promotes virus virulence in the murine intranasal model.

D. Tscharke, H. Waldmann, Geoffrey L. Smith, 2002, The Journal of general virology.

Combined use of RS61443 with CD4 and CD8 MAbs to generate tolerance to skin xenografts from rat to mouse.

S. Metcalfe, H. Waldmann, S. Cobbold, 1994, Transplantation proceedings.