D. Broide

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Systemic Administration of Immunostimulatory DNA Sequences Mediates Reversible Inhibition of Th2 Responses in a Mouse Model of Asthma

E. Raz, D. Broide, G. Stachnick, 2001, Journal of Clinical Immunology.

Human Mesenchymal Stem Cells Suppress the Stretch–Induced Inflammatory miR-155 and Cytokines in Bronchial Epithelial Cells

O. Lee, Y. Li, S. Chien, 2013, PloS one.

Inhibition of experimental asthma by indoleamine 2,3-dioxygenase.

E. Raz, D. Broide, D. Carson, 2004, The Journal of clinical investigation.

Allergic Disease

D. Broide, 2020, Berkowitz’s Pediatrics Instructor’s Guide.

Immunomodulation of allergic disease.

D. Broide, 2009, Annual review of medicine.

Advances in mechanisms of asthma, allergy, and immunology in 2008.

D. Broide, J. Boyce, Kenji Matsumoto, 2009, The Journal of allergy and clinical immunology.

Immunologic and inflammatory mechanisms that drive asthma progression to remodeling.

D. Broide, 2008, The Journal of allergy and clinical immunology.

Cytokines in symptomatic asthma airways.

D. Broide, S. Wasserman, M. Lotz, 1992, The Journal of allergy and clinical immunology.

TL1A Promotes Lung Tissue Fibrosis and Airway Remodeling

M. Croft, D. Broide, Marina Miller, 2020, The Journal of Immunology.

Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma

D. Broide, G. Hur, 2019, Allergy, asthma & immunology research.

Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice.

E. Gelfand, E. Raz, J. Schwarze, 1998, Journal of immunology.

Inhibition of airway remodeling in IL-5-deficient mice.

D. Broide, J. Nayar, Marina Miller, 2004, The Journal of clinical investigation.

Cytokines and growth factors in airway remodeling in asthma.

D. Broide, T. Doherty, 2007, Current opinion in immunology.

Group 2 innate lymphoid cells: new players in human allergic diseases.

D. Broide, T. Doherty, 2015, Journal of investigational allergology & clinical immunology.

Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production.

M. Croft, D. Broide, Sean J Lund, 2013, The Journal of allergy and clinical immunology.

STAT6 regulates natural helper cell proliferation during lung inflammation initiated by Alternaria.

M. Croft, D. Broide, T. Doherty, 2012, American journal of physiology. Lung cellular and molecular physiology.

Inhibition of eosinophilic inflammation in allergen-challenged TNF receptor p55/p75--and TNF receptor p55-deficient mice.

D. Broide, G. Stachnick, D. Castaneda, 2001, American journal of respiratory cell and molecular biology.

Platelets attach to lung type 2 innate lymphoid cells (ILC2s) expressing P-selectin glycoprotein ligand 1 and influence ILC2 function

D. Broide, Marina Miller, Maya R. Karta, 2019, Journal of Allergy and Clinical Immunology.

Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils.

A. Varki, D. Broide, Marina Miller, 2007, Blood.

Airway Remodeling Allergen-Induced Eosinophilic Inflammation Anti-Siglec-F Antibody Reduces

A. Varki, M. Croft, D. Broide, 2009 .

Anti-Siglec-F Antibody Reduces Allergen-Induced Eosinophilic Inflammation and Airway Remodeling1

A. Varki, M. Croft, D. Broide, 2009, The Journal of Immunology.

The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling

S. Fukuyama, C. Ware, S. Scheu, 2011, Nature Medicine.

Cytokines in chronic inflammatory arthritis. I. Failure to detect T cell lymphokines (interleukin 2 and interleukin 3) and presence of macrophage colony-stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis

G. Firestein, D. Broide, N. Zvaifler, 1988, The Journal of experimental medicine.

Airway innate lymphoid cells in the induction and regulation of allergy

D. Broide, T. Doherty, 2018, Allergology international : official journal of the Japanese Society of Allergology.

Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease

D. Broide, Maya R. Karta, T. Doherty, 2016, Current Allergy and Asthma Reports.

Prostaglandin D2 regulates human type 2 innate lymphoid cell chemotaxis.

D. Broide, T. Doherty, Jinny E. Chang, 2014, The Journal of allergy and clinical immunology.

Chapter 12 – Eosinophil-Mediated Tissue Remodeling and Fibrosis

G. Falk, D. Robinson, E. A. Kelly, 2013 .

Toll-Like Receptor-9 Agonist Inhibits Airway Inflammation, Remodeling and Hyperreactivity in Mice Exposed to Chronic Environmental Tobacco Smoke and Allergen

D. Broide, Marina Miller, D. Song, 2009, International Archives of Allergy and Immunology.

Why is Chromosome 17q21 linked to Asthma

D. Broide, Sudipta Das, 2016 .

ORMDL3 Transgenic Mice Have Increased Airway Remodeling and Airway Responsiveness Characteristic of Asthma

D. Broide, Marina Miller, M. Niwa, 2014, The Journal of Immunology.

DNA–Based Immunization for Asthma

E. Raz, D. Broide, 1999, International Archives of Allergy and Immunology.

Hypoxia-inducible factor-1α inhibition modulates airway hyperresponsiveness and nitric oxide levels in a BALB/c mouse model of asthma.

D. Broide, D. Nagle, K. Akong, 2017, Clinical immunology.

TNFA deletion alters apoptosis as well as caspase 3 and 4 expression during otitis media

M. Hernandez, A. Leichtle, H. Sudhoff, 2011, BMC Immunology.

Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites

D. Broide, P. Seeberger, M. Fukuda, 2014, Proceedings of the National Academy of Sciences.

Core 2 oligosaccharides mediate eosinophil and neutrophil peritoneal but not lung recruitment.

D. Broide, D. Castaneda, J. Nayar, 2002, American journal of physiology. Lung cellular and molecular physiology.

3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis

Gregory I. Elliott, R. Abagyan, Jongdae Lee, 2007, Proceedings of the National Academy of Sciences.

Immunostimulatory DNA inhibits allergen-induced peribronchial angiogenesis in mice.

E. Raz, D. Broide, Marina Miller, 2006, The Journal of allergy and clinical immunology.

Adiponectin-deficient mice are protected against tobacco-induced inflammation and increased emphysema.

D. Broide, Marina Miller, P. Rosenthal, 2010, American journal of physiology. Lung cellular and molecular physiology.

Immunotherapy With a Ragweed-Toll-Like Receptor 9 Agonist Vaccine for Allergic Rhinitis

R. Coffman, J. Schroeder, D. Broide, 2007, Pediatrics.

Expression That Promotes Airway Fibrosis Airway Eosinophilia and Epithelial FIZZ1 Induces STAT6-Dependent Acute Alternaria

D. Sheppard, M. Croft, D. Broide, 2017 .

Epithelial Thickness Expression That Promotes Airway Fibrosis Airway Eosinophilia and Epithelial FIZZ 1 Induces STAT 6-Dependent Acute Alternaria

D. Sheppard, M. Croft, D. Broide, 2012 .

Eosinophil Tissue Recruitment to Sites of Allergic Inflammation in the Lung Is Platelet Endothelial Cell Adhesion Molecule Independent1

K. Sung, D. Broide, D. Castaneda, 2001, The Journal of Immunology.

Combination of corticosteroid therapy and allergen avoidance reverses allergen-induced airway remodeling in mice.

D. Broide, Marina Miller, K. McElwain, 2005, The Journal of allergy and clinical immunology.

Eosinophils express interleukin 5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics.

G. Firestein, D. Broide, M. M. Paine, 1992, The Journal of clinical investigation.

Esophageal remodeling in pediatric eosinophilic esophagitis.

D. Broide, S. Aceves, R. Dohil, 2007, The Journal of allergy and clinical immunology.

Reduced peribronchial fibrosis in allergen-challenged MMP-9-deficient mice.

D. Broide, Marina Miller, K. McElwain, 2006, American journal of physiology. Lung cellular and molecular physiology.

Targeting AMCase reduces esophageal eosinophilic inflammation and remodeling in a mouse model of egg induced eosinophilic esophagitis.

D. Broide, Marina Miller, S. Aceves, 2014, International immunopharmacology.

Genes Associated with Food Allergy and Eosinophilic Esophagitis

D. Broide, 2013 .

Mast cell TNF mRNA expression in nasal mucosa demonstrated by in situ hybridization: a comparison of mast cell detection methods.

D. Broide, T. Davidson, W. Anderson, 1996, Journal of immunological methods.

Chapter 2: Innate Immunity

D. Broide, S. Turvey, 2010 .

Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease

Aaron N. Chang, C. Murre, D. Broide, 2014, Nature Immunology.

Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-β1, and increase esophageal smooth muscle contraction.

D. Broide, S. Aceves, R. Dohil, 2010, The Journal of allergy and clinical immunology.

DNA‐based immunotherapeutics for the treatment of allergic disease

E. Raz, D. Broide, J. Zubeldia, 2001, Immunological reviews.

Compartmentalization of eosinophil granulocyte-macrophage colony-stimulating factor expression in patients with asthma.

D. Broide, S. Sullivan, Susan K. Sullivan, 1996, The Journal of allergy and clinical immunology.

Differential expression of vascular cell adhesion molecule mRNA and protein in nasal mucosa in response to IL-1 or tumor necrosis factor.

D. Broide, T. Davidson, M. Weinberger, 1996, The Journal of allergy and clinical immunology.

Increased ILC2s in the eosinophilic nasal polyp endotype are associated with corticosteroid responsiveness.

Andrew A. White, D. Broide, Marina Miller, 2014, Clinical immunology.

Lung Type 2 innate lymphoid cells express CysLT1R that regulates Th2 cytokine production

M. Croft, D. Broide, Sean J Lund, 2013 .

Molecular and cellular mechanisms of allergic disease.

D. Broide, 2001, The Journal of allergy and clinical immunology.

Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy.

M. Matho, D. Zajonc, D. Broide, 2012, The Journal of clinical investigation.

Epithelial Cell-Derived IL-25, but Not Th17 Cell-Derived IL-17 or IL-17F, Is Crucial for Murine Asthma

K. Ohta, S. Nakae, D. Broide, 2012, The Journal of Immunology.

Endobronchial allergen challenge in asthma. Demonstration of cellular source of granulocyte macrophage colony-stimulating factor by in situ hybridization.

G. Firestein, D. Broide, 1991, The Journal of clinical investigation.

Advances in mechanisms of asthma, allergy, and immunology in 2010.

F. Finkelman, D. Broide, M. Rothenberg, 2011, The Journal of allergy and clinical immunology.

Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway.

D. Broide, G. Gleich, S. Wasserman, 1991, The Journal of allergy and clinical immunology.

Eosinophilic inflammation is associated with elevation of interleukin-5 in the airways of patients with spontaneous symptomatic asthma.

D. Broide, G. Gleich, K. Bartemes, 1995, The Journal of allergy and clinical immunology.

Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate

D. Broide, Marina Miller, M. Niwa, 2017, The Journal of Immunology.

Oroscomucoid like protein 3 (ORMDL3) transgenic mice have reduced levels of sphingolipids including sphingosine-1-phosphate and ceramide.

D. Broide, Marina Miller, R. Gordillo, 2017, The Journal of allergy and clinical immunology.

Environmental tobacco smoke exposure does not prevent corticosteroids reducing inflammation, remodeling, and airway hyperreactivity in mice exposed to allergen.

D. Broide, Marina Miller, D. Song, 2009, American journal of physiology. Lung cellular and molecular physiology.

MMPs-2 and -14 Are Elevated in Eosinophilic Esophagitis and Reduced Following Topical Corticosteroid Therapy

D. Broide, S. Aceves, R. Kurten, 2015, Journal of pediatric gastroenterology and nutrition.

Pathways to limit group 2 innate lymphoid cell activation.

D. Broide, T. Doherty, 2017, The Journal of allergy and clinical immunology.

Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma

P. Insel, Jongdae Lee, E. Raz, 2015, Proceedings of the National Academy of Sciences.

Modulation of asthmatic response by immunostimulatory DNA sequences

E. Raz, D. Broide, G. Stachnick, 2009, Springer Seminars in Immunopathology.

Genes that regulate eosinophilic inflammation.

D. Broide, P. Sriramarao, H. Hoffman, 1999, American journal of human genetics.

INSIGHTS FROM MODEL SYSTEMS Genes That Regulate Eosinophilic Inflammation

D. Broide, H. Hoffman, P. Sriramarao, 1999 .

Lidocaine in bronchoalveolar lavage fluid (BALF) is an inhibitor of eosinophil‐active cytokines

H. Kita, A. N. Mayeno, D. Broide, 1996, Clinical and experimental immunology.

PI3K gamma-deficient mice have reduced levels of allergen-induced eosinophilic inflammation and airway remodeling.

D. Broide, Marina Miller, D. Song, 2009, American journal of physiology. Lung cellular and molecular physiology.

Down-regulation of Caveolin-1, an Inhibitor of Transforming Growth Factor-β Signaling, in Acute Allergen-induced Airway Remodeling*

R. Shohet, V. Douet, D. Broide, 2008, Journal of Biological Chemistry.

Inhibition of eosinophilic inflammation in allergen-challenged, IL-1 receptor type 1-deficient mice is associated with reduced eosinophil rolling and adhesion on vascular endothelium.

D. Broide, P. Sriramarao, T. Gifford, 2000, Blood.

Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin, and IL-33.

M. Croft, D. Broide, D. Proud, 2016, The Journal of allergy and clinical immunology.

Segmental allergen challenge increases levels of airway follistatin-like 1 in patients with asthma.

N. Jarjour, J. Ramsdell, M. Croft, 2016, The Journal of allergy and clinical immunology.

Granulocyte-macrophage colony-stimulating factor regulates the functional adhesive state of very late antigen-4 expressed by eosinophils.

K. Sung, M. Elices, D. Broide, 1997, Journal of immunology.

Anti-IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis.

D. Broide, S. Aceves, R. Dohil, 2013, The Journal of allergy and clinical immunology.

Inhibition of allergic inflammation in the lung by plasmid DNA allergen immunization

E. Raz, D. Broide, M. Roman, 1999, Pediatric pulmonology. Supplement.

Inhibition of IgE formation and allergic inflammation by allergen gene immunization

E. Raz, D. Broide, M. Roman, 1998, Allergy.

Chronic OVA allergen challenged TNF p55/p75 receptor deficient mice have reduced airway remodeling.

D. Broide, Marina Miller, T. Doherty, 2011, International immunopharmacology.

CD4+ cells are required for chronic eosinophilic lung inflammation but not airway remodeling.

M. Croft, D. Broide, P. Soroosh, 2009, American journal of physiology. Lung cellular and molecular physiology.

Allergen-induced peribronchial fibrosis and mucus production mediated by IκB kinase β-dependent genes in airway epithelium

M. Karin, T. Lawrence, D. Broide, 2005 .

Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation.

Hiroyuki Takahashi, Michael Karin, M. Karin, 2010, Cancer cell.

Inactivation of I kappaB-kinase-beta dependent genes in airway epithelium reduces tobacco smoke induced acute airway inflammation.

M. Karin, D. Broide, Marina Miller, 2010, International immunopharmacology.

Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium.

M. Karin, T. Lawrence, D. Broide, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Resolution of airway inflammation following ovalbumin inhalation: comparison of ISS DNA and corticosteroids.

E. Raz, D. Broide, J. Nayar, 2003, American journal of respiratory cell and molecular biology.

Molecular Determinants of T Cell Epitope

Ravi V. Kolla, Bjoern Peters, J. Sidney, 2010 .

Prostaglandin I2 Signaling and Inhibition of Group 2 Innate Lymphoid Cell Responses.

S. Mallal, D. Broide, R. Peebles, 2015, American journal of respiratory and critical care medicine.

The TGFβ1 Promoter SNP C-509T and Food Sensitization Promote Esophageal Remodeling in Pediatric Eosinophilic Esophagitis

V. Bafna, D. Broide, S. Aceves, 2015, PloS one.

TGF-β1-induced phospholamban expression alters esophageal smooth muscle cell contraction in patients with eosinophilic esophagitis.

D. Broide, S. Aceves, R. Dohil, 2014, The Journal of allergy and clinical immunology.

TGFb1-induced phospholamban expression alters esophageal smooth muscle cell contraction in eosinophilic esophagitis

D. Broide, S. Aceves, A. Anilkumar, 2014 .

Does reduced zona pellucida binding protein 2 (ZPBP2) expression on chromosome 17q21 protect against asthma?

D. Broide, Marina Miller, Y. J. Kim, 2018, Journal of Allergy and Clinical Immunology.

Regulated production of the T helper 2-type T-cell chemoattractant TARC by human bronchial epithelial cells in vitro and in human lung xenografts.

M. Kagnoff, L. Eckmann, D. Broide, 2001, American journal of respiratory cell and molecular biology.

Allergen challenge in allergic rhinitis rapidly induces increased peripheral blood type 2 innate lymphoid cells that express CD84.

D. Broide, Marina Miller, Sean J Lund, 2014, The Journal of allergy and clinical immunology.

New targets for allergic rhinitis — a disease of civilization

S. Holgate, D. Broide, 2003, Nature Reviews Drug Discovery.

Coexposure to Environmental Tobacco Smoke Increases Levels of Allergen-Induced Airway Remodeling in Mice1

D. Broide, Marina Miller, D. Song, 2007, The Journal of Immunology.

Prospects for TLR9-Based Immunotherapy for Asthma and Allergy

D. Broide, 2008 .

Lipid Mediator Regulation of Group 2 Innate Lymphoid Cells

D. Broide, Maya R. Karta, T. Doherty, 2016 .

Immunomodulation and reversal of airway remodeling in asthma

D. Broide, 2004, Current opinion in allergy and clinical immunology.

ORMDL3 expression in ASM regulates hypertrophy, hyperplasia via TPM1 and TPM4, and contractility

D. Broide, Marina Miller, B. Oliver, 2021, JCI insight.

Why Is ORMDL3 on Chromosome 17q21 Highly Linked to Asthma?

D. Broide, Marina Miller, 2019, American journal of respiratory and critical care medicine.

Activating transcription factor 6α (ATF6α) regulates airway hyperreactivity, smooth muscle proliferation, and contractility.

D. Broide, Marina Miller, Sudipta Das, 2018, The Journal of allergy and clinical immunology.

Rhinovirus Infection of ORMDL3 Transgenic Mice Is Associated with Reduced Rhinovirus Viral Load and Airway Inflammation

M. Croft, D. Broide, Marina Miller, 2017, The Journal of Immunology.

Sialyltransferase ST3Gal-III Regulates Siglec-F Ligand Formation and Eosinophilic Lung Inflammation in Mice

A. Varki, D. Broide, Marina Miller, 2013, The Journal of Immunology.

Lung Inflammation in Mice Siglec-F Ligand Formation and Eosinophilic Sialyltransferase ST3Gal-III Regulates

A. Varki, D. Broide, Marina Miller, 2013 .

ORMDL3 but not neighboring 17q21 gene LRRC3C is expressed in human lungs and lung cells of asthmatics

D. Broide, Marina Miller, G. Hur, 2020, Allergy.

RESEARCH ARTICLE Biomarkers in Lung Diseases: From Pathogenesis to Prediction to New Therapies Autophagy plays a role in FSTL1-induced epithelial mesenchymal transition and airway remodeling in asthma

D. Broide, Marina Miller, Liang Dong, 2017 .

Immunologic treatment of allergic diseases

H. Malling, D. Broide, 2001, Current opinion in allergy and clinical immunology.

α4 Integrin-induced cytokine production and eosinophil function

D. Broide, 2004, Springer Seminars in Immunopathology.

CYTOKINES IN CHRONIC INFLAMMATORY ARTHRITIS

G. Firestein, D. Broide, N. Zvaifler, 2022 .

Constitutive overexpression of IL-5 induces extramedullary hematopoiesis in the spleen.

D. Broide, M. Rothenberg, L. Sikora, 2003, Blood.

Inhibition of pulmonary eosinophilia in P-selectin- and ICAM-1-deficient mice.

D. Broide, P. Sriramarao, T. Gifford, 1998, American journal of respiratory cell and molecular biology.

Strategies to Query and Display Allergy-Derived Epitope Data from the Immune Epitope Database

Bjoern Peters, A. Sette, A. Pomés, 2012, International Archives of Allergy and Immunology.

Adiponectin and Functional Adiponectin Receptor 1 Are Expressed by Airway Epithelial Cells in Chronic Obstructive Pulmonary Disease1

J. Ramsdell, D. Broide, Marina Miller, 2009, The Journal of Immunology.

Chromosome 17q21 SNP rs8076131 risk allele associates with airway smooth muscle hypertrophy in fatal asthma

A. James, D. Broide, Marina Miller, 2020, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Remodeling associated expression of matrix metalloproteinase 9 but not tissue inhibitor of metalloproteinase 1 in airway epithelium: modulation by immunostimulatory DNA.

E. Raz, D. Broide, Marina Miller, 2006, The Journal of allergy and clinical immunology.

Variable Fraction of Total Response to Are Differently Polarized and Account for a T Cell Responses to Known Allergen Proteins

Ravi V. Kolla, J. Greenbaum, Bjoern Peters, 2012 .

Chronic allergen challenge induces bronchial mast cell accumulation in BALB/c but not C57BL/6 mice and is independent of IL-9

D. Broide, Marina Miller, A. Pemberton, 2010, Immunogenetics.

Allergic rhinitis: Pathophysiology.

D. Broide, 2010, Allergy and asthma proceedings.

The pathophysiology of allergic rhinoconjunctivitis.

D. Broide, 2007, Allergy and asthma proceedings.

Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 496 adults from San Diego, California, USA.

S. Mallal, J. Sidney, A. Sette, 2018, Human Immunology.

ProductionSpecificity and Relationship to IgE Allergens from German Cockroach: Epitope Analysis of T Cell Responses to the Major

Ravi V. Kolla, J. Greenbaum, Bjoern Peters, 2012 .

Towards Defining Molecular Determinants Recognized by Adaptive Immunity in Allergic Disease: An Inventory of the Available Data

J. Greenbaum, Bjoern Peters, H. Grey, 2011, Journal of allergy.

Immunostimulatory DNA inhibits transforming growth factor-beta expression and airway remodeling.

E. Raz, D. Broide, J. Nayar, 2004, American journal of respiratory cell and molecular biology.

Association Between Specific Timothy Grass Antigens and Changes in Thelper 1 and 2 Cell Responses Following Specific Immunotherapy

J. Greenbaum, Bjoern Peters, J. Sidney, 2014 .

Cell/Cytokine Interactions

D. Broide, 1998 .

Immunostimulatory DNA for Allergic Asthma

D. Broide, K. Takabayashi, Reid K. Ikeda, 2002 .

Accumulation of Peribronchial Mast Cells in a Mouse Model of Ovalbumin Allergen Induced Chronic Airway Inflammation: Modulation by Immunostimulatory DNA Sequences1

E. Raz, D. Broide, J. Nayar, 2003, The Journal of Immunology.

SequencesModulation by Immunostimulatory DNA Induced Chronic Airway Inflammation: a Mouse Model of Ovalbumin Allergen Accumulation of Peribronchial Mast Cells in

E. Raz, D. Broide, J. Nayar, 2003 .

Leukotriene C4 Potentiates IL-33 Induced ILC2 Activation and Lung Inflammation Through CysLT1R

D. Broide, A. Portillo, T. Doherty, 2015 .

Remodeling by Inducing Oncostatin M Fstl1 Promotes Asthmatic Airway

Xiang Gao, Christine, M. Croft, 2015 .

Immunostimulatory DNA Reverses Established Allergen-Induced Airway Remodeling1

E. Raz, D. Broide, J. Nayar, 2004, The Journal of Immunology.

Segmental allergen challenge increases levels of airway FSTL1 in asthmatics

N. Jarjour, M. Croft, D. Broide, 2016 .

Remodeling Established Allergen-Induced Airway Immunostimulatory DNA Reverses

E. Raz, D. Broide, J. Nayar, 2004 .

Immunostimulatory DNA mediates inhibition of eosinophilic inflammation and airway hyperreactivity independent of natural killer cells in vivo.

E. Raz, D. Broide, G. Stachnick, 2001, The Journal of allergy and clinical immunology.

Immunostimulatory DNA sequences inhibit respiratory syncytial viral load, airway inflammation, and mucus secretion.

E. Raz, D. Broide, D. Castaneda, 2001, The Journal of allergy and clinical immunology.

Siglec-F Inhibition Reduces Esophageal Eosinophilia and Angiogenesis in a Mouse Model of Eosinophilic Esophagitis

A. Varki, D. Broide, Marina Miller, 2011, Journal of pediatric gastroenterology and nutrition.

Leukotriene C4 Potentiates IL-33–Induced Group 2 Innate Lymphoid Cell Activation and Lung Inflammation

M. Croft, D. Broide, A. Portillo, 2017, The Journal of Immunology.

Inhibition of eosinophil rolling and recruitment in P-selectin- and intracellular adhesion molecule-1-deficient mice.

D. Broide, D. Humber, P. Sriramarao, 1998, Blood.

Airway fibrosis and angiogenesis due to eosinophil trafficking in chronic asthma.

D. Broide, S. Aceves, 2008, Current molecular medicine.

Group 2 innate lymphoid cells are recruited to the nasal mucosa in patients with aspirin‐exacerbated respiratory disease

Andrew A. White, D. Broide, A. Deconde, 2017, The Journal of allergy and clinical immunology.

Myeloid differentiation primary response gene 88 is required for the resolution of otitis media.

M. Hernandez, A. Leichtle, A. Ryan, 2008, The Journal of infectious diseases.

&bgr;2 integrins rather than &bgr;1 integrins mediate Alternaria‐induced group 2 innate lymphoid cell trafficking to the lung

D. Broide, Marina Miller, R. Kurten, 2018, The Journal of allergy and clinical immunology.

Indoleamine-2,3-dioxygenase modulation of allergic immune responses

D. Broide, A. V. Le, Annie V. Le, 2006, Current allergy and asthma reports.

E-selectin preferentially supports neutrophil but not eosinophil rolling under conditions of flow in vitro and in vivo.

D. Broide, C. Norton, B. Wolitzky, 1996, Journal of immunology.

Environmental and bronchoalveolar lavage Dermatophagoides pteronyssinus antigen levels in atopic asthmatics.

D. Broide, P. Ferguson, 1995, American journal of respiratory and critical care medicine.

Gene immunization for allergic disorders

D. Broide, M. Roman, H. Spiegelberg, 2004, Springer Seminars in Immunopathology.

Genetic immunization for allergy immunotherapy.

E. Raz, D. Broide, M. Roman, 2000, Methods in molecular medicine.

Potent inhibitors of pro-inflammatory cytokine production produced by a marine-derived bacterium.

D. Broide, H. Kwon, P. Jensen, 2009, Journal of medicinal chemistry.

Chapter 20 – Cytokines, Chemokines, and Adhesion Proteins

D. Broide, 2006 .

Cellular Adhesion in Inflammation

D. Broide, P. Sriramarao, 2014 .

Group 2 innate lymphocytes (ILC2) are enriched in active eosinophilic esophagitis.

D. Broide, S. Aceves, R. Kurten, 2015, The Journal of allergy and clinical immunology.

Experimental Asthma Receptor 2 Induces a Th 2 Immune Response Cutting Edge : Activation of Toll-Like Fermin

E. Raz, D. Broide, P. Pitha, 2004 .

Induction and Inhibition of the Th2 Phenotype Spread: Implications for Childhood Asthma1

E. Raz, D. Broide, Tomoko Hayashi, 2005, The Journal of Immunology.

Childhood Asthma Phenotype Spread: Implications for Induction and Inhibition of the Th2

E. Raz, D. Broide, Tomoko Hayashi, 2005 .

Airway levels of mast cell-derived mediators in exercise-induced asthma.

D. Broide, S. Wasserman, L. Schwartz, 1990, The American review of respiratory disease.

EOSINOPHILIA IN AIDS

D. Broide, H. Hoffman, 1997, Radiologic Clinics of North America.

Eotaxin induces a sustained reduction in the functional adhesive state of very late antigen 4 for the connecting segment 1 region of fibronectin.

D. Broide, G. Stachnick, D. Castaneda, 2000, The Journal of allergy and clinical immunology.

Fast flowing eosinophils: signals for stopping and stepping out of blood vessels.

D. Broide, 2002, American journal of respiratory cell and molecular biology.

Transforming growth factor-beta 1 selectively inhibits IL-3-dependent mast cell proliferation without affecting mast cell function or differentiation.

G. Firestein, D. Broide, N. Zvaifler, 1989, Journal of immunology.

Anti-Siglec-F antibody inhibits oral egg allergen induced intestinal eosinophilic inflammation in a mouse model.

A. Varki, D. Broide, Marina Miller, 2009, Clinical immunology.

Mouse bone marrow-derived mast cells roll on P-selectin under conditions of flow in vivo.

D. Broide, B. Wolitzky, P. Sriramarao, 1996, Laboratory investigation; a journal of technical methods and pathology.

1 – Introduction to mechanisms of allergic disease

D. Broide, H. Oettgen, 2012 .

Plasmid DNA encoding the respiratory syncytial virus G protein protects against RSV-induced airway hyperresponsiveness.

E. Raz, D. Broide, D. Castaneda, 2002, Vaccine.

Persistent airway inflammation and emphysema progression on CT scan in ex-smokers observed for 4 years.

P. Friedman, J. Ramsdell, D. Broide, 2011, Chest.

Immunostimulatory DNA is a potent mucosal adjuvant.

E. Raz, D. Broide, M. Nguyen, 1998, Cellular immunology.

Lipid regulation of group 2 innate lymphoid cell function: Moving beyond epithelial cytokines.

D. Broide, T. Doherty, 2018, The Journal of allergy and clinical immunology.

TGF-β1-induced PAI-1 contributes to a profibrotic network in patients with eosinophilic esophagitis.

D. Broide, S. Aceves, R. Kurten, 2016, The Journal of allergy and clinical immunology.

TGFβ1-Induced PAI-1 Contributes to a Pro-Fibrotic Network in Eosinophilic Esophagitis

Aquino, D. Broide, S. Aceves, 2016 .

Functional and biochemical characterization of rat bone marrow derived mast cells.

D. Broide, D. Metcalfe, S. Wasserman, 1988, Journal of immunology.

Innate immunity.

D. Broide, S. Turvey, 2010, The Journal of allergy and clinical immunology.

Cutting Edge: Activation of Toll-Like Receptor 2 Induces a Th2 Immune Response and Promotes Experimental Asthma1

E. Raz, D. Broide, P. Pitha, 2004, The Journal of Immunology.

GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation

Q. Hamid, D. Broide, Marina Miller, 2016, Proceedings of the National Academy of Sciences.

Lung-resident tissue macrophages generate Foxp3+ regulatory T cells and promote airway tolerance

Zbigniew Mikulski, Michael Croft, Peter Rosenthal, 2013, The Journal of experimental medicine.

Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses

P. Insel, J. González-Navajas, E. Raz, 2019, bioRxiv.

Lack of allergy to timothy grass pollen is not a passive phenomenon but associated with the allergen‐specific modulation of immune reactivity

J. Greenbaum, Bjoern Peters, J. Sidney, 2016, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Chromosome 17q21 Genes ORMDL3 and GSDMB in Asthma and Immune Diseases.

D. Broide, Marina Miller, Sudipta Das, 2017, Advances in immunology.

DNA Vaccination for Asthma

D. Broide, 2005 .

Fine structure mapping of CIAS1: identification of an ancestral haplotype and a common FCAS mutation, L353P

S. Gregory, R. Kolodner, D. Broide, 2003, Human Genetics.

Familial cold autoinflammatory syndrome: phenotype and genotype of an autosomal dominant periodic fever.

D. Broide, H. Hoffman, A. Wanderer, 2001, The Journal of allergy and clinical immunology.

Long-term assessment of esophageal remodeling in patients with pediatric eosinophilic esophagitis treated with topical corticosteroids.

D. Broide, S. Aceves, R. Dohil, 2016, The Journal of allergy and clinical immunology.

Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation.

M. Karin, H. Ogata, D. Broide, 2010, Cancer cell.

From Molecular Science to the Treatment of Allergy

M. Manns, Jane Wilkinson, P. Hufnagl, 1999, International Archives of Allergy and Immunology.

Autophagy plays a role in FSTL1-induced epithelial mesenchymal transition and airway remodeling in asthma.

D. Broide, Marina Miller, Liang Dong, 2017, American journal of physiology. Lung cellular and molecular physiology.

An antiinflammatory role for IKKβ through the inhibition of “classical” macrophage activation

M. Karin, T. Lawrence, D. Broide, 2008, The Journal of experimental medicine.

Reconstitution of the Mast Cell Population in W/Wv Mice

H. Sudhoff, A. Ryan, D. Broide, 2010, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

Transmission of Human Herpesvirus 8 by Blood Transfusion

J. Schroeder, D. Broide, P. Creticos, 2007 .

IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis.

D. Broide, Marina Miller, J. Witztum, 2004, The Journal of clinical investigation.

Overview of defining features of innate and adaptive immunity : Comparing and contrasting some of the defining features of the innate and adaptive immune systems Innate immune system Adaptive immune system Cellular elements Hematopoietic cells : macrophages

D. Broide, S. Turvey, British Chb B Vancouver, 2022 .

Role of mast cells in otitis media.

H. Sudhoff, A. Ryan, D. Broide, 2005, The Journal of allergy and clinical immunology.

Allergen-Induced Coexpression of bFGF and TGF-β1 by Macrophages in a Mouse Model of Airway Remodeling: bFGF Induces Macrophage TGF-β1 Expression in vitro

D. Broide, Marina Miller, J. Y. Cho, 2010, International Archives of Allergy and Immunology.

Transcriptional Profiling of Th2 Cells Identifies Pathogenic Features Associated with Asthma

Bjoern Peters, A. Sette, D. Broide, 2016, The Journal of Immunology.

Smad3-Deficient Mice Have Reduced Esophageal Fibrosis and Angiogenesis in a Model of Egg-Induced Eosinophilic Esophagitis

D. Broide, Marina Miller, S. Aceves, 2014, Journal of pediatric gastroenterology and nutrition.

Orosomucoid‐like 3 (ORMDL3) upregulates airway smooth muscle proliferation, contraction, and Ca2+ oscillations in asthma

M. Sanderson, D. Broide, Marina Miller, 2017, The Journal of allergy and clinical immunology.

ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6

D. Broide, Marina Miller, M. Niwa, 2012, Proceedings of the National Academy of Sciences.

A strategy to determine HLA class II restriction broadly covering the DR, DP, and DQ allelic variants most commonly expressed in the general population

Bjoern Peters, J. Sidney, A. Sette, 2013, Immunogenetics.

Molecular Determinants of T Cell Epitope Recognition to the Common Timothy Grass Allergen

Bjoern Peters, John Sidney, Alessandro Sette, 2010, The Journal of Immunology.

Corticosteroids prevent myofibroblast accumulation and airway remodeling in mice.

D. Broide, Marina Miller, J. Shim, 2006, American journal of physiology. Lung cellular and molecular physiology.

Analysis of T Cell Responses to the Major Allergens from German Cockroach: Epitope Specificity and Relationship to IgE Production

Ravi V. Kolla, J. Greenbaum, Bjoern Peters, 2012, The Journal of Immunology.

Previously undescribed grass pollen antigens are the major inducers of T helper 2 cytokine-producing T cells in allergic individuals

Ravi V. Kolla, J. Greenbaum, Bjoern Peters, 2013, Proceedings of the National Academy of Sciences.

T Cell Responses to Known Allergen Proteins Are Differently Polarized and Account for a Variable Fraction of Total Response to Allergen Extracts

Ravi V. Kolla, J. Greenbaum, Bjoern Peters, 2012, The Journal of Immunology.

Association between specific timothy grass antigens and changes in TH1- and TH2-cell responses following specific immunotherapy.

J. Greenbaum, Bjoern Peters, J. Sidney, 2014, The Journal of allergy and clinical immunology.

The identification of potentially pathogenic and therapeutic epitopes from common human allergens.

Bjoern Peters, A. Sette, D. Broide, 2013, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

L-selectin and very late antigen-4 integrin promote eosinophil rolling at physiological shear rates in vivo.

E. Butcher, U. V. von Andrian, D. Broide, 1994, Journal of immunology.

Identification of a locus on chromosome 1q44 for familial cold urticaria.

F. Wright, R. Kolodner, D. Broide, 2000, American journal of human genetics.

DNA Immunotherapeutics: New Potential Treatment Modalities for Allergic Disease

E. Raz, D. Broide, Hiroko Kobayashi, 1998, International Archives of Allergy and Immunology.

Alternaria Induces STAT6-Dependent Acute Airway Eosinophilia and Epithelial FIZZ1 Expression That Promotes Airway Fibrosis and Epithelial Thickness

D. Sheppard, M. Croft, D. Broide, 2012, The Journal of Immunology.

Pulmonary Disease Epithelial Cells in Chronic Obstructive Receptor 1 Are Expressed by Airway Adiponectin and Functional Adiponectin

J. Ramsdell, D. Broide, Marina Miller, 2008 .

Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function

V. Nizet, D. Broide, R. Johnson, 2013, Journal of Molecular Medicine.

Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13

A. Varki, D. Broide, Marina Miller, 2010, Respiratory research.

Inhibition of Allergen-Induced Airway Remodeling in Smad 3-Deficient Mice1

D. Broide, Marina Miller, K. Golgotiu, 2007, The Journal of Immunology.

Remodeling in Smad 3-Deficient Mice Inhibition of Allergen-Induced Airway

D. Broide, Marina Miller, K. Golgotiu, 2007 .

Regulatory B cells and T follicular helper cells are reduced in allergic rhinitis.

D. Broide, Marina Miller, R. Kurten, 2016, The Journal of allergy and clinical immunology.

Eosinophil trafficking to sites of allergic inflammation

D. Broide, P. Sriramarao, 2001, Immunological reviews.

Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function

V. Nizet, D. Broide, R. Johnson, 2012, Journal of Molecular Medicine.

miR-23∼27∼24 clusters control effector T cell differentiation and function

Ming-Ling Kuo, Hyang-Mi Lee, Klaus Rajewsky, 2016, The Journal of experimental medicine.

Smad-3 Deficient Mice Have Reduced Esophageal Fibrosis in a Model of Eosinophilic Esophagitis

D. Broide, S. Aceves, P. Rosenthal, 2013 .

A comparison of C3a and C5a-mediated stable adhesion of rolling eosinophils in postcapillary venules and transendothelial migration in vitro and in vivo.

D. Broide, R. Discipio, M. Jagels, 1999, Journal of immunology.

A murine model to study leukocyte rolling and intravascular trafficking in lung microvessels.

D. Broide, L. Sikora, P. Sriramarao, 2003, The American journal of pathology.

New perspectives on mechanisms underlying chronic allergic inflammation and asthma in 2007.

D. Broide, 2008, The Journal of allergy and clinical immunology.

Migration In Vitro and In Vivo Postcapillary Venules and Transendothelial Stable Adhesion of Rolling Eosinophils in A Comparison of C 3 a and C 5 a-Mediated

D. Broide, R. Discipio, M. Jagels, 1998 .

Hypoxia potentiates allergen induction of HIF-1α, chemokines, airway inflammation, TGF-β1, and airway remodeling in a mouse model.

V. Nizet, D. Broide, L. Alexander, 2013, Clinical immunology.

Tumor necrosis factor family member LIGHT acts with IL‐1β and TGF‐β to promote airway remodeling during rhinovirus infection

M. Croft, D. Broide, A K Mehta, 2018, Allergy.

Mast cells and pulmonary fibrosis. Identification of a histamine releasing factor in bronchoalveolar lavage fluid.

D. Broide, S. Wasserman, C. M. Smith, 1990, Journal of immunology.

Differential Regulation of Eosinophil Adhesion under Conditions of Flow In Vivo a

D. Broide, P. Sriramarao, 1996, Annals of the New York Academy of Sciences.

VCAM-1 is more effective than MAdCAM-1 in supporting eosinophil rolling under conditions of shear flow.

M. Cybulsky, M. Elices, D. Broide, 2000, Blood.

Fstl1 Promotes Asthmatic Airway Remodeling by Inducing Oncostatin M

M. Croft, Q. Hamid, D. Broide, 2015, The Journal of Immunology.

Immunostimulatory sequences of DNA and conjugates in the treatment of allergic rhinitis

D. Broide, 2005, Current allergy and asthma reports.

Computed tomographic scan-diagnosed chronic obstructive pulmonary disease-emphysema: eotaxin-1 is associated with bronchodilator response and extent of emphysema.

P. Friedman, J. Ramsdell, D. Broide, 2007, The Journal of allergy and clinical immunology.

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

R. Kolodner, D. Broide, James L. Mueller, 2001, Nature Genetics.

Reduced AIBP expression in bronchial epithelial cells of asthmatic patients: Potential therapeutic target

A. Osterman, D. Broide, Marina Miller, 2022, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Endobronchial allergen challenge in asthma. Demonstration of cellular source of granulocyte macrophage colony-stimulating factor by in situ hybridization.

G. Firestein, D. Broide, 1991, The Journal of clinical investigation.

Erratum: Inhibition of eosinophil rolling and recruitment in P-selectin- and intracellular adhesion molecule-1 deficient mice (Blood (April 15, 1998) 91(8) (2847-2856))

D. Broide, D. Humber, P. Sriramarao, 1998 .

Resolution of remodeling in eosinophilic esophagitis correlates with epithelial response to topical corticosteroids

D. Broide, S. Aceves, James L. Mueller, 2010, Allergy.

Acute renal dysfunction caused by nonsucrose intravenous immunoglobulin in common variable immunodeficiency.

D. Broide, A. Kim, 2017, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

Endobronchial Allergen Challenge in Asthma Demonstration of Cellular Source of Granulocyte Macrophage Colony-stimulating Factor by In Situ Hybridization

G. Firestein, D. Broide, 2003 .

Single‐base editing of rs12603332 on chromosome 17q21 with a cytosine base editor regulates ORMDL3 and ATF6α expression

Alexis C. Komor, D. Broide, Marina Miller, 2021, Allergy.

Hypoxia-inducible factor-1α inhibition modulates airway hyperresponsiveness and nitric oxide levels in a BALB/c mouse model of asthma.

D. Broide, D. Nagle, K. Akong, 2017, Clinical immunology.

Immunologic and inflammatory mechanisms that drive asthma progression to remodeling.

D. Broide, 2008, The Journal of allergy and clinical immunology.

This information is current as Remodeling by Inducing Oncostatin M Fstl 1 Promotes Asthmatic Airway

Xiang Gao, Christine, M. Croft, 2015 .

Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils.

A. Varki, D. Broide, Marina Miller, 2007, Blood.

T Cell Responses to Known Allergen Proteins Are Differently Polarized and Account for a Variable Fraction of Total Response to Allergen Extracts

Ravi V. Kolla, J. Greenbaum, Bjoern Peters, 2012, The Journal of Immunology.

Anti-IL-5 therapy reduces mast cell and IL-9 cell numbers in pediatric patients with eosinophilic esophagitis.

D. Broide, S. Aceves, R. Dohil, 2013, The Journal of allergy and clinical immunology.

Immunomodulation of allergic disease.

D. Broide, 2009, Annual review of medicine.

DNA vaccines: an evolving approach to the treatment of allergic disorders.

D. Broide, 2005, Allergy and Asthma Proceedings.

Prostaglandin I2 Signaling and Inhibition of Group 2 Innate Lymphoid Cell Responses.

D. Broide, Melissa H. Bloodworth, D. Newcomb, 2015, American journal of respiratory and critical care medicine.

Characterization of Eosinophilic Esophagitis Murine Models Using Optical Coherence Tomography References and Links

R. D. Ferguson, J. Glessner, H. Hakonarson, 2022 .

An antiinflammatory role for IKKβ through the inhibition of “classical” macrophage activation

M. Karin, T. Lawrence, D. Broide, 2008, The Journal of experimental medicine.

Molecular Determinants of T Cell Epitope Recognition to the Common Timothy Grass Allergen

Ravi V. Kolla, Bjoern Peters, J. Sidney, 2010, The Journal of Immunology.

This information is current as Pulmonary Disease Epithelial Cells in Chronic Obstructive Receptor 1 Are Expressed by Airway Adiponectin and Functional Adiponectin and

D. Broide, Marina Miller, J. Y. Cho, 2008 .

Eosinophil peroxidase differs from neutrophil myeloperoxidase in its ability to bind antineutrophil cytoplasmic antibodies reactive with myeloperoxidase.

D. Broide, R. Breen, S. Sullivan, 1994, International archives of allergy and immunology.

A strategy to determine HLA class II restriction broadly covering the DR, DP, and DQ allelic variants most commonly expressed in the general population

Bjoern Peters, J. Sidney, A. Sette, 2013, Immunogenetics.

Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis.

D. Broide, P. Creticos, Robert G. Hamilton, 2006, The New England journal of medicine.