Seongkyu Yoon

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Characterization of mammalian cell culture raw materials by combining spectroscopy and chemometrics

Seongkyu Yoon, Nicholas Trunfio, Cyrus Agarabi, 2017, Biotechnology progress.

Data fusion‐based assessment of raw materials in mammalian cell culture

Seongkyu Yoon, Andrew Christie, Seongkyu Yoon, 2012, Biotechnology and bioengineering.

Integration of Time-Series Transcriptomic Data with Genome-Scale CHO Metabolic Models for mAb Engineering

Seongkyu Yoon, Zhuangrong Huang, 2020, Processes.

Process Analytical Technology and Quality by Design for Animal Cell Culture

Seongkyu Yoon, H. Lee, Zhuangrong Huang, 2019, Cell Culture Engineering.

Quantitative intracellular flux modeling and applications in biotherapeutic development and production using CHO cell cultures

Dong-Yup Lee, Seongkyu Yoon, Zhuangrong Huang, 2017, Biotechnology and bioengineering.

Prediction of critical quality attributes and optimization of continuous dry granulation process via flowsheet modeling and experimental validation

Seongkyu Yoon, H. Lee, Zhuangrong Huang, 2018 .

Integrated modeling of a continuous direct compression tablet manufacturing process: A production scale case study

Seongkyu Yoon, Zhuangrong Huang, Seo-Young Park, 2019, Powder Technology.

Intracellular metabolic flux analysis of CHO cells supplemented with wheat hydrolysates for improved mAb production and cell‐growth

E. Read, Jason A. Starkey, Seongkyu Yoon, 2015 .

Kinetic Modeling of Mammalian Cell Culture Bioprocessing: The Quest to Advance Biomanufacturing

Kok Siong Ang, Dong-Yup Lee, Rudiyanto Gunawan, 2018, Biotechnology journal.

Cellular and metabolic engineering of oleaginous yeast Yarrowia lipolytica for bioconversion of hydrophobic substrates into high‐value products

Seongkyu Yoon, Y. Soong, Na Liu, 2019, Engineering in life sciences.

Decision support in machine vision system for monitoring of TFT-LCD glass substrates manufacturing

Seongkyu Yoon, Jun-Hyung Ryu, J. Jay Liu, 2014 .

Automatic Grading of TFT–LCD Glass Substrates Using Optimized Support Vector Machines††An abridged version of this paper appears in the Proceedings of the ADCHEM 2012, Singapore, July 2012.

J. J. Liu, Seongkyu Yoon, A. Jazi, 2012 .

Effect of amino acid supplementation on titer and glycosylation distribution in hybridoma cell cultures—Systems biology‐based interpretation using genome‐scale metabolic flux balance model and multivariate data analysis

C. Agarabi, K. Brorson, Seongkyu Yoon, 2016, Biotechnology progress.

Reproducibility, complementary measure of predictability for robustness improvement of multivariate calibration models via variable selections.

Seongkyu Yoon, Seongkyu Yoon, H. Lee, 2012, Analytica chimica acta.

Quantification of protein mixture in chromatographic separation using multi‐wavelength UV spectra

Seongkyu Yoon, Jay Liu, Seongkyu Yoon, 2013, Biotechnology progress.

Chromatography bioseparation technologies and in-silico modelings for continuous production of biotherapeutics.

Seongkyu Yoon, Ketki Behere, 2020, Journal of chromatography. A.

Integrated continuous biomanufacturing platform with ATF perfusion and one column chromatography operation for optimum resin utilization and productivity

Maurizio V. Cattaneo, Seongkyu Yoon, M. Kamga, 2018, Preparative biochemistry & biotechnology.

Protein a resin lifetime study: Evaluation of protein a resin performance with a model-based approach in continuous capture

Seongkyu Yoon, B. Cha, Ketki Behere, 2018, Preparative biochemistry & biotechnology.

Impact of media and antifoam selection on monoclonal antibody production and quality using a high throughput micro‐bioreactor system

Sai Rashmika Velugula-Yellela, C. Agarabi, Nicholas Trunfio, 2017, Biotechnology progress.

Bioprocess Technologies that Preserve the Quality of iPSCs.

Seongkyu Yoon, Ashli Polanco, B. Kuang, 2020, Trends in biotechnology.

Prediction of N-linked Glycoform Profiles of Monoclonal Antibody with Extracellular Metabolites and Two-Step Intracellular Models

C. Agarabi, S. Lute, K. Brorson, 2019, Processes.

Pattern within a Fluidized Bed Granulator : by Full-Factorial Design of Fluidization Velocity and Particle Size

Seongkyu Yoon, Mingzhong Li, Huolong Liu, 2016 .

Process Analytical Technologies in Biopharmaceutical Process Development

K. Gernaey, A. Rathore, Seongkyu Yoon, 2015 .

Consequences of trace metal variability and supplementation on Chinese hamster ovary (CHO) cell culture performance: A review of key mechanisms and considerations

Seongkyu Yoon, Hemlata Bhatia, Ryan J. Graham, 2019, Biotechnology and bioengineering.

Zinc supplementation improves the harvest purity of β-glucuronidase from CHO cell culture by suppressing apoptosis

Celia N. Cruz, C. N. Madhavarao, Seongkyu Yoon, 2019, Applied Microbiology and Biotechnology.

FLOWSHEET MODELING OF A CONTINUOUS DIRECT COMPRESSION TABLETING PROCESS AT PRODUCTION SCALE

Seongkyu Yoon, Zhuangrong Huang, S. Galbraith, 2016 .

Optimization of the manufacturing process of a complex amphotericin B liposomal formulation using quality by design approach.

Seongkyu Yoon, Huolong Liu, D. Kozak, 2020, International journal of pharmaceutics.

Linking process variables to residence time distribution in a hybrid flowsheet model for continuous direct compression

Robert Meyer, Huolong Liu, Shaun C. Galbraith, 2020 .

Development of a three-compartmental population balance model for a continuous twin screw wet granulation process

Seongkyu Yoon, Seo-Young Park, S. Galbraith, 2018 .

Dielectric spectroscopy‐based estimation of VCD in CHO cell culture

K. Brorson, Seongkyu Yoon, H. Lee, 2015 .

At-line N-linked glycan profiling for monoclonal antibodies with advanced sample preparation and high-performance liquid chromatography.

Seongkyu Yoon, Sha Sha, Na Liu, 2020, Journal of bioscience and bioengineering.

An investigation of nucleotide sugar dynamics under the galactose supplementation in CHO cell culture

Seongkyu Yoon, Sha Sha, 2019, Process Biochemistry.

Metabolic responses and pathway changes of mammalian cells under different culture conditions with media supplementations

C. Agarabi, K. Brorson, Seongkyu Yoon, 2018, Biotechnology progress.

Identifying metabolic features and engineering targets for productivity improvement in CHO cells by integrated transcriptomics and genome-scale metabolic model

Seongkyu Yoon, Zhuangrong Huang, 2020 .

Single in‐line biomass probe detects CHO cell growth by capacitance and bacterial contamination by conductivity in bioreactor

Caitlin S. Morris, C. N. Madhavarao, Seongkyu Yoon, 2021, Biotechnology journal.

A high-resolution measurement of nucleotide sugars by using ion-pair reverse chromatography and tandem columns

C. Agarabi, Seongkyu Yoon, Sha Sha, 2020, Analytical and Bioanalytical Chemistry.

Zinc supplementation modulates intracellular metal uptake and oxidative stress defense mechanisms in CHO cell cultures

C. N. Madhavarao, Seongkyu Yoon, M. Ashraf, 2021 .

A Thermodynamic Balance Model for Liquid Film Drying Kinetics of a Tablet Film Coating and Drying Process

Seongkyu Yoon, Zhuangrong Huang, Seo-Young Park, 2019, AAPS PharmSciTech.

Amphotericin B release rate is the link between drug status in the liposomal bilayer and toxicity

Jaeweon Lee, Seongkyu Yoon, Jiwen Zheng, 2022, Asian journal of pharmaceutical sciences.

Critical process parameters in manufacturing of liposomal formulations of amphotericin B.

Seongkyu Yoon, Ja Hye Myung, Seongkyu Yoon, 2019, International journal of pharmaceutics.

Physicochemical surrogates for in vitro toxicity assessment of liposomal amphotericin B.

Jaeweon Lee, Seongkyu Yoon, Jiwen Zheng, 2022, International journal of pharmaceutics.

The Current Scientific and Regulatory Landscape in Advancing Integrated Continuous Biopharmaceutical Manufacturing.

Kurt Brorson, Seongkyu Yoon, Cyrus Agarabi, 2019, Trends in biotechnology.

A design space exploration for control of Critical Quality Attributes of mAb.

Kurt Brorson, Seongkyu Yoon, Hemlata Bhatia, 2016, International journal of pharmaceutics.

MicroRNA-146a inhibits epithelial mesenchymal transition in non-small cell lung cancer by targeting insulin receptor substrate 2.

Dong Sun Kim, Soo Young Lee, J. Park, 2015, International journal of oncology.

Design space determination and process optimization in at-scale continuous twin screw wet granulation

Brandye Smith-Goettler, Huolong Liu, Thomas O'Connor, 2019, Comput. Chem. Eng..

Optimization of critical quality attributes in continuous twin-screw wet granulation via design space validated with pilot scale experimental data.

Brandye Smith-Goettler, Seongkyu Yoon, Huolong Liu, 2017, International journal of pharmaceutics.

Generation of reference cell lines, media, and a process platform for CHO cell biomanufacturing

Harnish Mukesh Naik, Venkata Gayatri Dhara, Caitlin S. Morris, 2022, Biotechnology and bioengineering.

Estimation of raw material performance in mammalian cell culture using near infrared spectra combined with chemometrics approaches

Seongkyu Yoon, Andrew Christie, Jun Liu, 2012, Biotechnology progress.

Mechanistic modeling and applications for CHO cell culture development and production

Seongkyu Yoon, Zhao Wang, Zhuangrong Huang, 2018, Current Opinion in Chemical Engineering.

Free light chain content in culture media reflects recombinant monoclonal antibody productivity and quality

Seongkyu Yoon, Jin Xu, Robert Smith, 2013, Biotechnology progress.

Bigdata analytics identifies metabolic inhibitors and promoters for productivity improvement and optimization of monoclonal antibody (mAb) production process

Caitlin S. Morris, Michael C. Borys, B. Warrack, 2020, Bioresources and Bioprocessing.

In‐line monitoring of amino acids in mammalian cell cultures using raman spectroscopy and multivariate chemometrics models

Seongkyu Yoon, Hemlata Bhatia, Hamidreza Mehdizadeh, 2018, Engineering in life sciences.

Robustness of chemometrics-based feature selection methods in early cancer detection and biomarker discovery

Seongkyu Yoon, Hae Woo Lee, Carl Lawton, 2013, Statistical applications in genetics and molecular biology.

CHO cell productivity improvement by genome-scale modeling and pathway analysis: Application to feed supplements

Zheng Jian Li, Zhuangrong Huang, Jianlin Xu, 2020 .

Media formulation optimization: current and future opportunities

Seongkyu Yoon, Hemlata Bhatia, Huolong Liu, 2018, Current Opinion in Chemical Engineering.

Addressing amino acid‐derived inhibitory metabolites and enhancing CHO cell culture performance through DOE‐guided media modifications

Venkata Gayatri Dhara, M. Betenbaugh, Seongkyu Yoon, 2023, Biotechnology and bioengineering.

Modulation of nutrient precursors for controlling metabolic inhibitors by genome‐scale flux balance analysis

Seongkyu Yoon, B. Kuang, Duc Hoang, 2022, Biotechnology progress.

Identification of novel inhibitory metabolites and impact verification on growth and protein synthesis in mammalian cells

Venkata Gayatri Dhara, S. Shaffer, M. Betenbaugh, 2021, Metabolic engineering communications.

Critical challenges and advances in recombinant adeno‐associated virus (rAAV) biomanufacturing

Seongkyu Yoon, Qiang Fu, Ashli Polanco, 2023, Biotechnology and bioengineering.

A Software Tool for Lyophilization Primary Drying Process Development and Scale-up Including Process Heterogeneity, I: Laboratory-Scale Model Testing

Alina A. Alexeenko, W. Kessler, Seongkyu Yoon, 2021, AAPS PharmSciTech.

Transcriptomic features reveal molecular signatures associated with recombinant adeno‐associated virus production in HEK293 cells

Seongkyu Yoon, Qiang Fu, Sha Sha, 2023, Biotechnology progress.

An RNA-seq based transcriptomic investigation into the productivity and growth variants with Chinese hamster ovary cells.

Seongkyu Yoon, Hemlata Bhatia, Sha Sha, 2018, Journal of biotechnology.

N-Glycosylation Design and Control of Therapeutic Monoclonal Antibodies.

Kurt Brorson, Seongkyu Yoon, Dong-Yup Lee, 2016, Trends in biotechnology.

Effect of iron addition on mAb productivity and oxidative stress in Chinese hamster ovary culture

Seongkyu Yoon, A. Mohammad, Qiang Fu, 2021, Biotechnology progress.

Characterization of dynamic regulation in Chinese hamster ovary (CHO) cell cultures in the late exponential phase

Seongkyu Yoon, Sha Sha, B. Kuang, 2021 .

Zinc supplementation improves the harvest purity of β-glucuronidase from CHO cell culture by suppressing apoptosis

Celia N. Cruz, C. N. Madhavarao, Seongkyu Yoon, 2019, Applied Microbiology and Biotechnology.

n-Layer BET adsorption isotherm modeling for multimeric Protein A ligand and its lifetime determination.

Seongkyu Yoon, Ketki Behere, 2020, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

A Compact Model for Lyophilizer Equipment Capability Estimation

Alina A. Alexeenko, W. Kessler, Seongkyu Yoon, 2021, AAPS PharmSciTech.

Characterization of Chinese hamster ovary cell culture feed media precipitate

Seongkyu Yoon, S. Galbraith, B. Kuang, 2021, Biotechnology progress (Print).

Real‐time quantification and supplementation of bioreactor amino acids to prolong culture time and maintain antibody product quality

Sai Rashmika Velugula-Yellela, David N. Powers, Erica J Fratz-Berilla, 2019, Biotechnology progress.

Modeling and Optimization of Continuous Viral Vaccine Production

Caitlin S. Morris, Seongkyu Yoon, 2022, Processes.

Environmentally benign synthesis of vinyl ester resin from biowaste glycerin

Yongwoon Lee, Seongkyu Yoon, A. Kokil, 2015 .

Modeling and simulation of continuous powder blending applied to a continuous direct compression process

Seongkyu Yoon, Huolong Liu, Zhuangrong Huang, 2018, Pharmaceutical development and technology.

Sustaining an efficient and effective CHO cell line development platform by incorporation of 24‐deep well plate screening and multivariate analysis

Seongkyu Yoon, Bernard Nabiswa, Gerald Carson, 2018, Biotechnology progress.

Three-dimensional computational fluid dynamics (CFD) study of the gas–particle circulation pattern within a fluidized bed granulator: By full factorial design of fluidization velocity and particle size

Seongkyu Yoon, Huolong Liu, Mingzhong Li, 2017 .

Effects of process parameters on tablet critical quality attributes in continuous direct compression: a case study of integrating data-driven statistical models and mechanistic compaction models

Seongkyu Yoon, Huolong Liu, Zhuangrong Huang, 2020, Pharmaceutical development and technology.

Early integration of Design of Experiment (DOE) and multivariate statistics identifies feeding regimens suitable for CHO cell line development and screening

Alessandro Mora, Sheng Zhang, Seongkyu Yoon, 2019, Cytotechnology.

Metabolic-sensing characteristics of absorption-photometry for mammalian cell cultures in biopharmaceutical processes

Jason A. Starkey, Seongkyu Yoon, Jin Xu, 2013 .

N-Glycosylation Design and Control of Therapeutic Monoclonal Antibodies.

C. Agarabi, K. Brorson, Dong-Yup Lee, 2016, Trends in biotechnology.

Biotechnology and Bioengineering

Seongkyu Yoon, Hemlata Bhatia, Ryan J. Graham, 2019 .

Adventitious agent detection methods in bio-pharmaceutical applications with a focus on viruses, bacteria, and mycoplasma.

Caitlin S. Morris, Seongkyu Yoon, Yong Suk Lee, 2021, Current opinion in biotechnology.