K. Takano

发表

Protein Evolution is Potentially Governed by Protein Stability: Directed Evolution of an Esterase from the Hyperthermophilic Archaeon Sulfolobus tokodaii

S. Sano, Ryo Kurahashi, K. Takano, 2018, Journal of Molecular Evolution.

The direction of protein evolution is destined by the stability.

S. Sano, Ryo Kurahashi, K. Takano, 2018, Biochimie.

Evolvability of thermophilic proteins from archaea and bacteria.

S. Kanaya, K. Takano, Atsushi Aoi, 2013, Biochemistry.

Open Access Research Article Evolution and Thermodynamics of the Slow Unfolding of Hyperstable Monomeric Proteins

S. Kanaya, K. Takano, Y. Koga, 2022 .

Contribution of hydrophobic residues to the stability of human lysozyme: calorimetric studies and X-ray structural analysis of the five isoleucine to valine mutants.

M. Oobatake, Y. Yamagata, E. Kanaya, 1996, Journal of molecular biology.

Contribution of intra- and intermolecular hydrogen bonds to the conformational stability of human lysozyme(,).

Y. Yamagata, S. Kuramitsu, K. Takano, 1999, Biochemistry.

Novel and Simple Screening Methods for Protein Crystallization by Vapor Diffusion Rate Control

K. Takano, Tsuyoshi Inoue, H. Adachi, 2004 .

Promotion of Crystal Nucleation of Protein by Semi-Solid Agarose Gel

Tsuyoshi Inoue, Yusuke Mori, Hiroaki Adachi, 2009 .

Laser Irradiated Growth of Protein Crystal

S. Kanaya, K. Takano, Tsuyoshi Inoue, 2003 .

Laser energy dependence on femtosecond laser-induced nucleation of protein

K. Takano, Tsuyoshi Inoue, S. Murakami, 2008 .

Enhancement of femtosecond laser-induced nucleation of protein in a gel solution

K. Takano, Tsuyoshi Inoue, S. Murakami, 2010 .

Laser-induced nucleation in protein crystallization: Local increase in protein concentration induced by femtosecond laser irradiation

S. Kanaya, K. Takano, Y. Koga, 2011 .

Urea denatured state ensembles contain extensive secondary structure that is increased in hydrophobic proteins

Kazufumi Takano, J. M. Scholtz, K. Takano, 2010, Protein science : a publication of the Protein Society.

Crystallization and preliminary X-ray analysis of the tRNA thiolation enzyme MnmA from Escherichia coli complexed with tRNAGlu

Tsuyoshi Inoue, Yusuke Mori, Hiroaki Adachi, 2006 .

Importance of the Ca2+-binding sites in the N-catalytic domain of a family I.3 lipase for activity and stability.

S. Kanaya, K. Takano, Y. Koga, 2008, Protein engineering, design & selection : PEDS.

Positive Contribution of Hydration Structure on the Surface of Human Lysozyme to the Conformational Stability*

Y. Yamagata, K. Takano, K. Yutani, 2002, The Journal of Biological Chemistry.

Effect of Gel–Solution Interface on Femtosecond Laser-Induced Nucleation of Protein

K. Takano, Tsuyoshi Inoue, S. Murakami, 2013 .

Femtosecond laser-induced nucleation of protein in agarose gel

K. Takano, Tsuyoshi Inoue, S. Murakami, 2009 .

Enzymatic activity of a subtilisin homolog, Tk-SP, from Thermococcus kodakarensis in detergents and its ability to degrade the abnormal prion protein

A. Sakudo, K. Ikuta, S. Kanaya, 2013, BMC Biotechnology.

Purification, crystallization and preliminary X-ray diffraction of SecDF, a translocon-associated membrane protein, from Thermus thermophilus.

Tsuyoshi Inoue, Yusuke Mori, Hiroaki Adachi, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

Laser ablation for protein crystal nucleation and seeding.

K. Takano, Tsuyoshi Inoue, S. Murakami, 2014, Chemical Society reviews.

Effect of solution flow produced by rotary shaker on protein crystallization

K. Takano, Tsuyoshi Inoue, S. Murakami, 2008 .

A Novel Approach for Protein Crystallization by a Synthetic Hydrogel with Thermoreversible Gelation Polymer

K. Takano, Tsuyoshi Inoue, S. Murakami, 2013 .

Crystal structure and structure-based mutational analyses of RNase HIII from Bacillus stearothermophilus: a new type 2 RNase H with TBP-like substrate-binding domain at the N terminus.

S. Kanaya, K. Takano, Y. Koga, 2006, Journal of molecular biology.

Identification of RNase HII from psychrotrophic bacterium, Shewanella sp. SIB1 as a high‐activity type RNase H

S. Kanaya, K. Takano, Y. Koga, 2006, The FEBS Journal.

Gene Cloning and Biochemical Characterizations of Thermostable Ribonuclease HIII from Bacillus stearothermophilus

S. Kanaya, K. Takano, H. Chon, 2004, Bioscience, biotechnology, and biochemistry.

Anaerobic glycerol-3-phosphate dehydrogenase complex from hyperthermophilic archaeon Thermococcus kodakarensis KOD1.

S. Kanaya, K. Takano, Y. Koga, 2019, Journal of bioscience and bioengineering.

Hyperthermophilic Subtilisin-Like Proteases From Thermococcus kodakarensis

S. Kanaya, K. Takano, Y. Koga, 2017 .

An alternative mature form of subtilisin homologue, Tk‐SP, from Thermococcus kodakaraensis identified in the presence of Ca2+

S. Kanaya, K. Takano, Y. Koga, 2011, The FEBS journal.

Growth of protein crystals in hydrogels prevents osmotic shock.

Tsuyoshi Inoue, Yusuke Mori, Hiroaki Adachi, 2012, Journal of the American Chemical Society.

A crystallization technique for obtaining large protein crystals with increased mechanical stability using agarose gel combined with a stirring technique

K. Takano, Tsuyoshi Inoue, S. Murakami, 2016 .

Spiral Growth Can Enhance Both the Normal Growth Rate and Quality of Tetragonal Lysozyme Crystals Grown under a Forced Solution Flow

K. Takano, Tsuyoshi Inoue, S. Murakami, 2015 .

A new practical technique for high quality protein crystallization with the solution stirring technique at the interface between high-concentrated hydrogel and solution

K. Takano, Tsuyoshi Inoue, S. Murakami, 2014 .

Protein Crystallization in Agarose Gel with High Strength: Developing an Automated System for Protein Crystallographic Processes

K. Takano, Tsuyoshi Inoue, S. Murakami, 2009 .

Femtosecond Laser Processing of Agarose Gel Surrounding Protein Crystals for Development of an Automated Crystal Capturing System

K. Takano, Tsuyoshi Inoue, S. Murakami, 2009 .

Growth of Protein Crystals by Syringe-Type Top-Seeded Solution Growth

K. Takano, Tsuyoshi Inoue, Tsutomu Nakamura, 2011 .

Effect of Evaporation on Protein Crystals Grown in Semi-Solid Agarose Hydrogel

K. Takano, Tsuyoshi Inoue, S. Murakami, 2011 .

Identification of the gene encoding a type 1 RNase H with an N‐terminal double‐stranded RNA binding domain from a psychrotrophic bacterium

S. Kanaya, K. Takano, Y. Koga, 2007, The FEBS journal.

Crystallization and preliminary crystallographic analysis of type 1 RNase H from the hyperthermophilic archaeon Sulfolobus tokodaii 7.

S. Kanaya, K. Takano, Y. Koga, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

Structural Basis for the Serratia marcescens Lipase Secretion System: Crystal Structures of the Membrane Fusion Protein and Nucleotide-Binding Domain.

S. Sano, H. Okano, S. Kanaya, 2017, Biochemistry.

Development of Polymorphic Control Technology for Pharmaceutical Compounds

K. Takano, Y. Mori, M. Maruyama, 2019, Kinetic Control in Synthesis and Self-Assembly.

Activity, stability, and structure of metagenome‐derived LC11‐RNase H1, a homolog of Sulfolobus tokodaii RNase H1

E. Kanaya, S. Kanaya, K. Takano, 2012, Protein science : a publication of the Protein Society.

Identification of the substrate binding site in the N‐terminal TBP‐like domain of RNase H3

S. Kanaya, K. Takano, Y. Koga, 2011, FEBS letters.

Crystal structure of a family I.3 lipase from Pseudomonas sp. MIS38 in a closed conformation

S. Kanaya, K. Takano, Y. Koga, 2007, FEBS letters.

Promotion of Large Protein Crystal Growth with Stirring Solution

K. Takano, H. Adachi, Y. Mori, 2002 .

Isolation and characterization of Rhodococcus sp. strains TMP2 and T12 that degrade 2,6,10,14-tetramethylpentadecane (pristane) at moderately low temperatures.

S. Kanaya, K. Takano, M. Haruki, 2005, Journal of biotechnology.

Gene cloning and in vivo characterization of a dibenzothiophene dioxygenase from Xanthobacter polyaromaticivorans

S. Kanaya, S. Hirano, K. Takano, 2006, Applied Microbiology and Biotechnology.

Requirement of Ca(2+) ions for the hyperthermostability of Tk-subtilisin from Thermococcus kodakarensis.

S. Kanaya, K. Takano, Y. Koga, 2012, Biochemistry.

Revisiting the Rate-Limiting Step of the ANS–Protein Binding at the Protein Surface and Inside the Hydrophobic Cavity

K. Takano, Shun-Ichi Tanaka, Chikashi Ota, 2021, Molecules.

Microflow system promotes acetaminophen crystal nucleation

K. Takano, Munenori Numata, Y. Mori, 2020, Engineering in life sciences.

FK506-Binding Protein 22 from a Psychrophilic Bacterium, a Cold Shock-Inducible Peptidyl Prolyl Isomerase with the Ability to Assist in Protein Folding

S. Kanaya, K. Takano, Y. Koga, 2011, International journal of molecular sciences.

Protein crystal growth with a two-liquid system and stirring solution.

K. Takano, Tsuyoshi Inoue, H. Adachi, 2004, Journal of synchrotron radiation.

Gentisate 1,2-Dioxygenase from Xanthobacter polyaromaticivorans 127W

S. Kanaya, S. Hirano, K. Takano, 2007, Bioscience, biotechnology, and biochemistry.

Contribution of salt bridges near the surface of a protein to the conformational stability.

Y. Yamagata, K. Takano, K. Yutani, 2000, Biochemistry.

Cleavage of Various Peptides with Pitrilysin from Escherichia coli: Kinetic Analyses Using β-Endorphin and Its Derivatives

S. Kanaya, K. Takano, M. Haruki, 2004, Bioscience, biotechnology, and biochemistry.

Crystallization and preliminary X-ray diffraction study of an active-site mutant of pro-Tk-subtilisin from a hyperthermophilic archaeon.

S. Kanaya, K. Takano, Y. Koga, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystallization and preliminary X-ray crystallographic analysis of a helicase-like domain from a tomato mosaic virus replication protein.

M. Ishikawa, E. Katoh, K. Takano, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

Inhibition of chymotrypsin- and subtilisin-like serine proteases with Tk-serpin from hyperthermophilic archaeon Thermococcus kodakaraensis.

S. Kanaya, K. Takano, Y. Koga, 2011, Biochimica et Biophysica Acta.

Preliminary X-ray analysis of the binding domain of the soybean vacuolar sorting receptor complexed with a sorting determinant of a seed storage protein.

B. Mikami, K. Takano, N. Maruyama, 2015, Acta crystallographica. Section F, Structural biology communications.

Crystallization and preliminary crystallographic studies of PotA, a membrane-associated ATPase of the spermidine-preferential uptake system in Thermotoga maritima.

K. Takano, K. Kashiwagi, Tsuyoshi Inoue, 2014, Acta crystallographica. Section F, Structural biology communications.

Expression, purification, crystallization and preliminary crystallographic analysis of spermidine acetyltransferase from Escherichia coli.

K. Takano, K. Kashiwagi, Tsuyoshi Inoue, 2013, Acta crystallographica. Section F, Structural biology and crystallization communications.

Growth of large protein crystals by a large‐scale hanging‐drop method

K. Takano, R. Kuroki, Tsuyoshi Inoue, 2010 .

Importance of an extreme C-terminal motif of a family I.3 lipase for stability.

S. Kanaya, K. Takano, Y. Koga, 2011, Protein engineering, design & selection : PEDS.

Spectroscopic Evidence of the Salt-Induced Conformational Change around the Localized Electric Charges on the Protein Surface of Fibronectin Type III.

K. Takano, Chikashi Ota, Shun-ichi Tanaka, 2020, Langmuir : the ACS journal of surfaces and colloids.

Subtilisin-like serine protease from hyperthermophilic archaeon Thermococcus kodakaraensis with N- and C-terminal propeptides.

S. Kanaya, K. Takano, Y. Koga, 2010, Protein engineering, design & selection : PEDS.

A Manipulating Tool for Protein Microcrystals in Solution Using Adhesive Materials

K. Takano, Tsuyoshi Inoue, S. Murakami, 2009 .

Evaluation and Improvement of a Technique to Manipulate Protein Crystals in Solution

K. Takano, Tsuyoshi Inoue, S. Murakami, 2008 .

Crystallization and preliminary X-ray crystallographic analysis of Ca2+-free primary Ca2+-sensor of Na+/Ca2+ exchanger.

K. Takano, K. Tomoo, Tsuyoshi Inoue, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

Extracellular overproduction and preliminary crystallographic analysis of a family I.3 lipase.

S. Kanaya, K. Takano, Y. Koga, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystallization and preliminary X-ray diffraction study of glycerol kinase from the hyperthermophilic archaeon Thermococcus kodakaraensis.

S. Kanaya, K. Takano, Y. Koga, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Crystallization and preliminary X-ray diffraction study of thermostable RNase HIII from Bacillus stearothermophilus.

S. Kanaya, K. Takano, Y. Koga, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Overproduction and preliminary crystallographic study of a human kynurenine aminotransferase II homologue from Pyrococcus horikoshii OT3.

S. Kanaya, K. Takano, Y. Koga, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Effects of entrapped gas on the surface of a plastic ball induced by ultrasonic irradiation on the enhancement of crystallization of acetaminophen form II

K. Tsukamoto, K. Takano, H. Adachi, 2021 .

Large-scale crystallization of acetaminophen trihydrate by a novel stirring technique

K. Tsukamoto, K. Takano, H. Adachi, 2019, Applied Physics Express.

Effect of Stirring Method on Protein Crystallization

K. Takano, Tsuyoshi Inoue, H. Adachi, 2004 .

Flavobacterium banpakuense sp. nov., isolated from leaf-and-branch compost.

E. Kanaya, S. Kanaya, K. Takano, 2011, International journal of systematic and evolutionary microbiology.

Flavobacterium compostarboris sp. nov., isolated from leaf-and-branch compost, and emended descriptions of Flavobacterium hercynium, Flavobacterium resistens and Flavobacterium johnsoniae.

E. Kanaya, S. Kanaya, K. Takano, 2012, International journal of systematic and evolutionary microbiology.

Heterologous Expression and Catalytic Properties of Codon-Optimized Small-Sized Bromelain from MD2 Pineapple

K. Takano, C. Budiman, V. Subbiah, 2022, Molecules.

Isolation of a Novel Cutinase Homolog with Polyethylene Terephthalate-Degrading Activity from Leaf-Branch Compost by Using a Metagenomic Approach

E. Kanaya, S. Kanaya, K. Takano, 2011, Applied and Environmental Microbiology.

Structure of amyloid beta fragments in aqueous environments.

S. Kanaya, K. Takano, Y. Koga, 2006, The FEBS journal.

Solution-mediated phase transition of pharmaceutical compounds: Case studies of acetaminophen and aspirin

K. Takano, M. Maruyama, H. Yoshikawa, 2022, Journal of Crystal Growth.

Stress Responses of Shade-Treated Tea Leaves to High Light Exposure after Removal of Shading

S. Sano, T. Masumura, S. Morita, 2020, Plants.

Alkyne Tagged Raman Probes for Protein by Chemical Modification Approach

S. Sano, K. Takano, K. Kuramochi, 2017 .

Crystallization of acetaminophen form II by plastic-ball-assisted ultrasonic irradiation

K. Takano, Tsuyoshi Inoue, S. Murakami, 2017 .

Behavior of Bovine Serum Albumin Molecules in Molecular Crowding Environments Investigated by Raman Spectroscopy.

K. Takano, Chikashi Ota, 2016, Langmuir : the ACS journal of surfaces and colloids.

Proteolysis of abnormal prion protein with a thermostable protease from Thermococcus kodakarensis KOD1

A. Sakudo, K. Ikuta, S. Kanaya, 2014, Applied Microbiology and Biotechnology.

Biofilm formation by a Bacillus subtilis strain that produces gamma-polyglutamate.

R. Kolter, S. Kanaya, K. Takano, 2006, Microbiology.

A Stable Protein - CutA1

S. Kanaya, K. Takano, Y. Koga, 2012 .

Requirement of insertion sequence IS1 for thermal adaptation of Pro-Tk-subtilisin from hyperthermophilic archaeon

S. Kanaya, K. Takano, Y. Koga, 2012, Extremophiles.

Crystal structure of Tk‐subtilisin folded without propeptide: Requirement of propeptide for acceleration of folding

S. Kanaya, K. Takano, Y. Koga, 2008, FEBS letters.

Contribution of hydrogen bonds to protein stability

C. Pace, B. Shirley, K. Gajiwala, 2014, Protein science : a publication of the Protein Society.

Crystallization of aspirin form II by femtosecond laser irradiation

K. Tsukamoto, K. Takano, Tsuyoshi Inoue, 2018, Applied Physics Express.

Selective crystallization of the metastable phase of indomethacin at the interface of liquid/air bubble induced by femtosecond laser irradiation

Masashi Yoshimura, Tsuyoshi Inoue, Kenji Ikeda, 2015 .

Role of amino acid residues in left‐handed helical conformation for the conformational stability of a protein

Y. Yamagata, K. Takano, K. Yutani, 2001, Proteins.

Quantitative analysis of calcium oxalate monohydrate and dihydrate for elucidating the formation mechanism of calcium oxalate kidney stones

K. Tsukamoto, K. Takano, R. Ando, 2022, bioRxiv.

Multicolor imaging of calcium-binding proteins in human kidney stones for elucidating the effects of proteins on crystal growth

K. Tsukamoto, K. Takano, R. Ando, 2021, Scientific Reports.

Metastable crystal growth of acetaminophen using solution-mediated phase transformation

K. Takano, Tsuyoshi Inoue, S. Murakami, 2016 .

Intergrowth of two aspirin polymorphism observed with Raman spectroscopy

K. Tsukamoto, K. Takano, H. Adachi, 2020 .

Growth of high-quality metastable crystal of acetaminophen using solution-mediated phase transformation at low supersaturation

K. Tsukamoto, K. Takano, Tsuyoshi Inoue, 2018, Journal of Crystal Growth.

Atomic-Scale Imaging of Surface and Hydration Structures of Stable and Metastable Acetaminophen Crystals by Frequency Modulation Atomic Force Microscopy

K. Takano, Tsuyoshi Inoue, S. Murakami, 2018, The Journal of Physical Chemistry C.

Improvement of metastable crystal of acetaminophen via control of crystal growth rate

K. Tsukamoto, K. Takano, Tsuyoshi Inoue, 2018 .

Selective crystallization of metastable phase of acetaminophen by ultrasonic irradiation

K. Takano, Tsuyoshi Inoue, S. Murakami, 2015 .

Promotion of protein crystal growth by actively switching crystal growth mode via femtosecond laser ablation

K. Tsukamoto, K. Takano, Tsuyoshi Inoue, 2016, Nature Photonics.

Contribution of the hydrophobic effect to the stability of human lysozyme: calorimetric studies and X-ray structural analyses of the nine valine to alanine mutants.

Y. Yamagata, K. Takano, K. Yutani, 1997, Biochemistry.

Crystal structure of a human kynurenine aminotransferase II homologue from Pyrococcus horikoshii OT3 at 2.20 Å resolution

S. Kanaya, K. Takano, Y. Koga, 2005, Proteins.

X-ray crystallographic and MD simulation studies on the mechanism of interfacial activation of a family I.3 lipase with two lids.

S. Kanaya, K. Takano, Y. Koga, 2010, Journal of molecular biology.

Universal Processing Technique for Protein Crystals Using Pulsed UV Laser

Tsuyoshi Inoue, Yusuke Mori, Hiroaki Adachi, 2004 .

Gene Cloning, Overproduction, and Characterization of Thermolabile Alkaline Phosphatase from a Psychrotrophic Bacterium

S. Kanaya, K. Takano, M. Haruki, 2005, Bioscience, biotechnology, and biochemistry.

Expression and characterization of functional domains of FK506-binding protein 35 from Plasmodium knowlesi.

Ryo Kurahashi, K. Takano, C. Budiman, 2018, Protein engineering, design & selection : PEDS.

Amyloid β Conformation in Aqueous Environment

K. Takano, 2008 .

Amyloid beta conformation in aqueous environment.

K. Takano, 2008, Current Alzheimer research.

Contribution of polar groups in the interior of a protein to the conformational stability.

Y. Yamagata, K. Takano, K. Yutani, 2001, Biochemistry.

Amyloid protofilament formation of hen egg lysozyme in highly concentrated ethanol solution

K. Namba, Y. Yamagata, K. Takano, 2008, Protein science : a publication of the Protein Society.

Exploring mutable conserved sites and fatal non-conserved sites by random mutation of esterase from Sulfolobus tokodaii and subtilisin from Thermococcus kodakarensis.

Ryo Kurahashi, K. Takano, A. Hirata, 2020, International journal of biological macromolecules.

Highly active enzymes produced by directed evolution with stability-based selection.

Ryo Kurahashi, K. Takano, Shun-ichi Tanaka, 2020, Enzyme and microbial technology.

Activity-stability trade-off in random mutant proteins.

Ryo Kurahashi, K. Takano, Shun-ichi Tanaka, 2019, Journal of bioscience and bioengineering.

Mutational and structural-based analyses of the osmolyte effect on protein stability.

S. Kanaya, M. Saito, K. Takano, 2004, Journal of biochemistry.

Slow Unfolding of Monomeric Proteins from Hyperthermophiles with Reversible Unfolding

K. Takano, A. Mukaiyama, 2009, International journal of molecular sciences.

Extracellular secretion of Escherichia coli alkaline phosphatase with a C-terminal tag by type I secretion system: purification and biochemical characterization.

S. Kanaya, K. Takano, Y. Koga, 2006, Protein engineering, design & selection : PEDS.

Strategy for cold adaptation of the tryptophan synthase α subunit from the psychrophile Shewanella frigidimarina K14-2: crystal structure and physicochemical properties.

N. Urano, M. Ishida, Daisuke Mitsuya, 2014, Journal of biochemistry.

Slow unfolding pathway of hyperthermophilic Tk-RNase H2 examined by pulse proteolysis using the stable protease Tk-subtilisin.

S. Kanaya, K. Takano, Y. Koga, 2012, Biochemistry.

Proline effect on the thermostability and slow unfolding of a hyperthermophilic protein.

S. Kanaya, K. Takano, Y. Koga, 2008, Journal of biochemistry.

Hydrophobic effect on the stability and folding of a hyperthermophilic protein.

Yuichi Koga, Kazufumi Takano, S. Kanaya, 2008, Journal of molecular biology.

Osmolyte effect on the stability and folding of a hyperthermophilic protein

S. Kanaya, K. Takano, Y. Koga, 2008, Proteins.

Kinetically robust monomeric protein from a hyperthermophile.

S. Kanaya, K. Takano, A. Mukaiyama, 2004, Biochemistry.

Importance of a repetitive nine‐residue sequence motif for intracellular stability and functional structure of a family I.3 lipase

Yuichi Koga, Aditya Paul, Kazufumi Takano, 2005, FEBS letters.

Heparanase Localization during Palatogenesis in Mice

K. Takano, Y. Koga, Hiroaki Nakamura, 2013, BioMed research international.

Effect of the disease‐causing mutations identified in human ribonuclease (RNase) H2 on the activities and stabilities of yeast RNase H2 and archaeal RNase HII

S. Kanaya, K. Takano, Y. Koga, 2008, The FEBS journal.

Structure and stability of a thermostable carboxylesterase from the thermoacidophilic archaeon Sulfolobus tokodaii

S. Kanaya, K. Takano, Y. Koga, 2012, The FEBS journal.

Biofilm formation by a Bacillus subtilis strain that produces γ-polyglutamate

R. Kolter, S. Kanaya, K. Takano, 2006 .

Delineation of the Conformational Thermostability of Hyperthermophilic Proteins Based on Structural and Biophysical Analyses

K. Takano, A. Mukaiyama, 2011 .

The N‐terminal hybrid binding domain of RNase HI from Thermotoga maritima is important for substrate binding and Mg2+‐dependent activity

E. Kanaya, S. Kanaya, K. Takano, 2010, The FEBS journal.

Cloning of the RNase H genes from a metagenomic DNA library: identification of a new type 1 RNase H without a typical active‐site motif

E. Kanaya, S. Kanaya, K. Takano, 2010, Journal of applied microbiology.

Are the parameters of various stabilization factors estimated from mutant human lysozymes compatible with other proteins?

K. Takano, K. Yutani, J. Funahashi, 2001, Protein engineering.

Contribution of amino acid substitutions at two different interior positions to the conformational stability of human lysozyme.

Y. Yamagata, K. Takano, K. Yutani, 1999, Protein engineering.

Crystallization and preliminary crystallographic analysis of orotidine 5'-monophosphate decarboxylase from the human malaria parasite Plasmodium falciparum.

S. Krungkrai, J. Krungkrai, T. Horii, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

Effect of extra N-terminal residues on the stability and folding of human lysozyme expressed in Pichia pastoris.

Y. Yamagata, K. Takano, K. Yutani, 2000, Protein engineering.

Requirement of a unique Ca(2+)-binding loop for folding of Tk-subtilisin from a hyperthermophilic archaeon.

S. Kanaya, K. Takano, Y. Koga, 2009, Biochemistry.

Structural and thermodynamic analyses of Escherichia coli RNase HI variant with quintuple thermostabilizing mutations

S. Kanaya, K. Takano, Y. Koga, 2007, The FEBS journal.

The Trial of Drug Discovery using the In-Silico Screening Methods Developed by Pharmaceutical Innovation Value Chain

Y. Fukunishi, Haruki Nakamura, Y. Okuno, 2010 .

Effect of foreign N-terminal residues on the conformational stability of human lysozyme.

Y. Yamagata, K. Takano, K. Yutani, 1999, European journal of biochemistry.

Directed evolution of Tk-subtilisin from a hyperthermophilic archaeon: identification of a single amino acid substitution responsible for low-temperature adaptation.

S. Kanaya, K. Takano, Y. Koga, 2007, Protein engineering, design & selection : PEDS.

Role of non‐glycine residues in left‐handed helical conformation for the conformational stability of human lysozyme

K. Takano, K. Yutani, Yuriko Yamagata, 2001, Proteins.

The Contribution of Polar Group Burial to Protein Stability Is Strongly Context-dependent*

C. Pace, J. M. Scholtz, J. Sacchettini, 2003, Journal of Biological Chemistry.

Engineering of monomeric FK506‐binding protein 22 with peptidyl prolyl cis‐trans isomerase

S. Kanaya, K. Takano, Y. Koga, 2009, The FEBS journal.

The structure, stability, and folding process of amyloidogenic mutant human lysozyme.

Kazufumi Takano, K. Takano, K. Yutani, 1996 .

Crystal structure of a GH1 β‐glucosidase from Hamamotoa singularis

K. Takano, H. Matsumura, R. Uehara, 2020, Protein science : a publication of the Protein Society.

Possible involvement of an FKBP family member protein from a psychrotrophic bacterium Shewanella sp. SIB1 in cold-adaptation.

S. Kanaya, K. Takano, M. Haruki, 2004, European journal of biochemistry.

Requirement of left-handed glycine residue for high stability of the Tk-subtilisin propeptide as revealed by mutational and crystallographic analyses.

S. Kanaya, K. Takano, Y. Koga, 2007, Journal of molecular biology.

Ca2+-Dependent Maturation of Subtilisin from a Hyperthermophilic Archaeon, Thermococcus kodakaraensis: the Propeptide Is a Potent Inhibitor of the Mature Domain but Is Not Required for Its Folding

S. Kanaya, K. Takano, Y. Koga, 2006, Applied and Environmental Microbiology.

Dispersion Effect of Molecular Crowding on Ligand-Protein Surface Binding Sites of Escherichia coli RNase HI.

K. Takano, Chikashi Ota, Shun-ichi Tanaka, 2022, Langmuir : the ACS journal of surfaces and colloids.

Affinity shift of ATP upon glycerol binding to a glycerol kinase from the hyperthermophilic archaeon Thermococcus kodakarensis KOD1.

S. Kanaya, K. Takano, Y. Koga, 2020, Journal of bioscience and bioengineering.

Molecular resolution investigation of tetragonal lysozyme (110) face in liquid by frequency-modulation atomic force microscopy

M. Ohta, Ryohei Kokawa, K. Takano, 2010 .

Crystal Structure of Unautoprocessed Precursor of Subtilisin from a Hyperthermophilic Archaeon

S. Kanaya, K. Takano, Y. Koga, 2007, Journal of Biological Chemistry.

Effect of ultrasonic irradiation on protein crystallization

Tsuyoshi Inoue, Yusuke Mori, Hiroaki Adachi, 2006 .

Influence of energy and wavelength on femtosecond laser-induced nucleation of protein

Tsuyoshi Inoue, Yusuke Mori, Hiroaki Adachi, 2011 .

Approach for growth of high-quality and large protein crystals

K. Takano, Tsuyoshi Inoue, S. Murakami, 2010, Journal of synchrotron radiation.

Role of surface hydrophobic residues in the conformational stability of human lysozyme at three different positions.

Y. Yamagata, K. Takano, K. Yutani, 2000, Biochemistry.

Effects of a Forced Solution Flow on the Step Advancement on {110} Faces of Tetragonal Lysozyme Crystals: Direct Visualization of Individual Steps under a Forced Solution Flow

K. Takano, Tsuyoshi Inoue, S. Murakami, 2012 .

Spectroscopic Signature of the Steric Strains in an Escherichia coli RNase HI Cavity-filling Destabilized Mutant Protein.

K. Takano, Chikashi Ota, Shun-ichi Tanaka, 2019, The journal of physical chemistry. B.

Spectroscopic Analysis of Protein-Crowded Environments Using the Charge-Transfer Fluorescence Probe 8-Anilino-1-Naphthalenesulfonic Acid.

K. Takano, Chikashi Ota, 2019, Chemphyschem : a European journal of chemical physics and physical chemistry.

Structure of amyloid β fragments in aqueous environments

S. Kanaya, K. Takano, Y. Koga, 2006 .

Processing of membrane protein crystal using ultraviolet laser irradiation.

Tsuyoshi Inoue, Yusuke Mori, Hiroaki Adachi, 2005, Journal of bioscience and bioengineering.

Protein Crystallization by Combining Laser Irradiation and Solution-Stirring Techniques

Tsuyoshi Inoue, Yusuke Mori, Hiroaki Adachi, 2005 .

Membrane Protein Crystallization Using Laser Irradiation

Tsuyoshi Inoue, Yusuke Mori, Hiroaki Adachi, 2004 .

Effects of pulse duration on laser-induced crystallization of urea from 300 to 1200 fs: impact of cavitation bubbles on crystal nucleation

K. Tsukamoto, K. Takano, H. Adachi, 2022, Applied Physics A.

Spatially Precise, Soft Microseeding of Single Protein Crystals by Femtosecond Laser Ablation

K. Takano, Tsuyoshi Inoue, S. Murakami, 2012 .

Femtosecond laser-induced cleaving of protein crystal in water solution

Hiroshi Masuhara, Tsuyoshi Inoue, Yusuke Mori, 2007 .

Development of protein crystallization and processing: femtosecond laser, all solid-state 193 nm laser, and solution stirring techniques

Tsuyoshi Inoue, Hiroshi Yoshikawa, Yusuke Mori, 2007, SPIE LASE.

Crystal structure of highly thermostable glycerol kinase from a hyperthermophilic archaeon in a dimeric form

S. Kanaya, K. Takano, Y. Koga, 2008, The FEBS journal.

Phylogenetic analysis of condensation domains in the nonribosomal peptide synthetases.

S. Kanaya, K. Takano, M. Morikawa, 2005, FEMS microbiology letters.

Evidence for Solution-Mediated Phase Transitions in Kidney Stones: Phase Transition Exacerbates Kidney Stone Disease

K. Tsukamoto, K. Takano, R. Ando, 2023, Crystal Growth & Design.

Characteristic Features of Kynurenine Aminotransferase Allosterically Regulated by (Alpha)-Ketoglutarate in Cooperation with Kynurenine

S. Kanaya, K. Takano, Y. Koga, 2012, PloS one.

Metastable Crystallization by Drop Impact

K. Takano, Y. Mori, M. Maruyama, 2022, Crystals.

Growth of Acetaminophen Polymorphic Crystals and Solution-Mediated Phase Transition from Trihydrate to Form II in Agarose Gel

K. Takano, Y. Mori, M. Maruyama, 2021, Crystals.

Protein Evolution is Potentially Governed by Protein Stability: Directed Evolution of an Esterase from the Hyperthermophilic Archaeon Sulfolobus tokodaii

S. Sano, Ryo Kurahashi, K. Takano, 2018, Journal of Molecular Evolution.

Conformational plasticity of RNA for target recognition as revealed by the 2.15 Å crystal structure of a human IgG–aptamer complex

Tsuyoshi Inoue, Yusuke Mori, Hiroaki Adachi, 2010, Nucleic acids research.

Crystallization and preliminary X-ray diffraction studies of an RNA aptamer in complex with the human IgG Fc fragment.

Yoshikazu Nakamura, K. Takano, Tsuyoshi Inoue, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

Investigating the structural dependence of protein stabilization by amino acid substitution.

Yuichi Koga, Kazufumi Takano, S. Kanaya, 2013, Biochemistry.

The stability and folding process of amyloidogenic mutant human lysozymes.

K. Takano, K. Yutani, J. Funahashi, 2001, European journal of biochemistry.

Effective Protein Crystallization Using Crystal Hysteresis

K. Takano, H. Adachi, Y. Mori, 2003 .

Contribution of water molecules in the interior of a protein to the conformational stability.

Y. Yamagata, K. Takano, K. Yutani, 1998, Journal of molecular biology.

Stabilization by Fusion to the C-terminus of Hyperthermophile Sulfolobus tokodaii RNase HI: A Possibility of Protein Stabilization Tag

S. Kanaya, K. Takano, Y. Koga, 2011, PloS one.

Protein core adaptability: crystal structures of the cavity-filling variants of Escherichia coli RNase HI.

S. Kanaya, K. Takano, Y. Koga, 2010, Protein and peptide letters.

Identification of the interactions critical for propeptide-catalyzed folding of Tk-subtilisin.

S. Kanaya, K. Takano, Y. Koga, 2009, Journal of molecular biology.

Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography

Yusuke Mori, Hiroaki Adachi, Kazuo Kurihara, 2009, Proceedings of the National Academy of Sciences.

Buried water molecules contribute to the conformational stability of a protein.

Yuriko Yamagata, Kazufumi Takano, Y. Yamagata, 2003, Protein engineering.

Crystal structure of N‐domain of FKBP22 from Shewanella sp. SIB1: Dimer dissociation by disruption of Val‐Leu knot

S. Kanaya, K. Takano, Y. Koga, 2011, Protein science : a publication of the Protein Society.

Binding analysis of a psychrotrophic FKBP22 to a folding intermediate of protein using surface plasmon resonance

Yuichi Koga, Kazufumi Takano, S. Kanaya, 2005, FEBS letters.

Stabilities and activities of the N‐ and C‐domains of FKBP22 from a psychrotrophic bacterium overproduced in Escherichia coli

S. Kanaya, K. Takano, Yutaka Suzuki, 2005, The FEBS journal.

A hyperthermophilic protein acquires function at the cost of stability.

Motonori Ota, Yuichi Koga, Kazufumi Takano, 2006, Biochemistry.

Contribution of hydrogen bonds to the conformational stability of human lysozyme: calorimetry and X-ray analysis of six tyrosine --> phenylalanine mutants.

Y. Yamagata, K. Takano, K. Yutani, 1998, Biochemistry.

Four new crystal structures of Tk-subtilisin in unautoprocessed, autoprocessed and mature forms: insight into structural changes during maturation.

S. Kanaya, K. Takano, Y. Koga, 2007, Journal of molecular biology.

Femtosecond laser processing of protein crystals grown in agarose gel

Tsuyoshi Inoue, Yusuke Mori, Hiroaki Adachi, 2009 .

Identification of Single Mn2+ Binding Sites Required for Activation of the Mutant Proteins of E. coli RNase HI at Glu48 and/or Asp134 by X-ray Crystallography

Hiroyoshi Matsumura, Yuriko Yamagata, Kazufumi Takano, 2005 .

A general rule for the relationship between hydrophobic effect and conformational stability of a protein: stability and structure of a series of hydrophobic mutants of human lysozyme.

Y. Yamagata, K. Takano, K. Yutani, 1998, Journal of molecular biology.

Amyloidogenecity and pitrilysin sensitivity of a lysine-free derivative of amyloid beta-peptide cleaved from a recombinant fusion protein.

S. Kanaya, K. Takano, Y. Koga, 2006, Journal of biotechnology.

Insertion loop‐mediated folding propagation governs efficient maturation of hyperthermophilic Tk‐subtilisin at high temperatures

S. Kanaya, K. Takano, Y. Koga, 2020, FEBS letters.

Experimental verification of the 'stability profile of mutant protein' (SPMP) data using mutant human lysozymes.

K Nishikawa, K. Nishikawa, M. Ota, 1999, Protein engineering.

Estimated effects of silicone glue on protein crystal growth

K. Takano, Tsuyoshi Inoue, S. Murakami, 2010 .

Application of a two-liquid system to sitting-drop vapour-diffusion protein crystallization.

S. Kanaya, K. Takano, H. Adachi, 2003, Acta crystallographica. Section D, Biological crystallography.

Effects of Solution Stirring on Protein Crystal Growth

K. Takano, Tsuyoshi Inoue, H. Matsumura, 2004 .

Identification of single Mn(2+) binding sites required for activation of the mutant proteins of E.coli RNase HI at Glu48 and/or Asp134 by X-ray crystallography.

Hiroyoshi Matsumura, Yuriko Yamagata, Kazufumi Takano, 2005, Journal of molecular biology.

Crystal structure of a subtilisin homologue, Tk-SP, from Thermococcus kodakaraensis: requirement of a C-terminal beta-jelly roll domain for hyperstability.

S. Kanaya, K. Takano, Y. Koga, 2010, Journal of molecular biology.

High-resolution structure of exo-arabinanase from Penicillium chrysogenum.

T. Kinoshita, K. Takano, Tsuyoshi Inoue, 2011, Acta crystallographica. Section D, Biological crystallography.

A new scale for side-chain contribution to protein stability based on the empirical stability analysis of mutant proteins.

K. Takano, K. Yutani, K Yutani, 2001, Protein engineering.

Structure, Stability and Binding Properties of Collagen-Binding Domains from Streptococcus mutans

K. Takano, R. Nomura, K. Nakano, 2023, Chemistry.

Development of protein seed crystals reinforced with high-strength hydrogels

K. Takano, H. Adachi, H. Matsumura, 2015 .

11 A Stable Protein – CutA 1

S. Kanaya, K. Takano, Y. Koga, 2018 .

Amyloid fibrils from the viewpoint of protein folding

K. Takano, S. Ohnishi, S. Ohnishi, 2004, Cellular and Molecular Life Sciences CMLS.

Destabilization of psychrotrophic RNase HI in a localized fashion as revealed by mutational and X‐ray crystallographic analyses

S. Kanaya, K. Takano, Y. Koga, 2009, The FEBS journal.

Protein thermostabilization requires a fine-tuned placement of surface-charged residues.

K. Nishikawa, S. Fukuchi, S. Kanaya, 2007, Journal of biochemistry.

Crystal structure of highly thermostable glycerol kinase from a hyperthermophilic archaeon in a dimeric form

S. Kanaya, K. Takano, Y. Koga, 2008, The FEBS journal.

Molecular mechanism underlying promiscuous polyamine recognition by spermidine acetyltransferase.

K. Takano, K. Kashiwagi, H. Adachi, 2016, The international journal of biochemistry & cell biology.

Contributory presentations/posters

Diederichs, Bosco K. Ho, Hironori K. Nakamura, 1999, Journal of Biosciences.

Structural, thermodynamic, and mutational analyses of a psychrotrophic RNase HI.

S. Kanaya, K. Takano, Y. Koga, 2007, Biochemistry.