J. Littlechild

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The structure of a thermally stable 3‐phosphoglycerate kinase and a comparison with its mesophilic equivalent

H. Watson, S. Gamblin, G. Davies, 1993, Proteins.

The structure of an alcohol dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix.

J. Littlechild, J. Guy, M. Isupov, 2003, Journal of molecular biology.

Phosphoglycerate kinase from the extreme thermophile Thermus thermophilus Crystallization and preliminary X‐ray data

H. Watson, S. Gamblin, G. Davies, 1987 .

Isoenzymes of phosphoglycerate kinase: evolutionary conservation of the structure of this glycolytic enzyme.

H. Watson, J. Littlechild, 1990, Biochemical Society transactions.

Purification, crystallization and preliminary X-ray analysis of the 3-phosphoglycerate kinase from Bacillus stearothermophilus.

H. Watson, S. Gamblin, G. Davies, 1992, Journal of molecular biology.

An NADPH-dependent genetic switch regulates plant infection by the rice blast fungus

N. Talbot, J. Littlechild, C. Quispe, 2010, Proceedings of the National Academy of Sciences.

Archaeal Enzymes and Applications in Industrial Biocatalysts

J. Littlechild, 2015, Archaea.

Crystal structure of the glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus.

J. Littlechild, M. Isupov, M. Isupov, 1999, Journal of molecular biology.

Metal and redox modulation of cysteine protein function.

Claus Jacob, J. Littlechild, C. Jacob, 2003, Chemistry & biology.

Crystal structure of human muscle aldolase complexed with fructose 1,6‐bisphosphate: Mechanistic implications

Z Dauter, J A Littlechild, Z. Dauter, 2008, Protein science : a publication of the Protein Society.

Lymphocytes from rheumatoid arthritis patients have elevated levels of intracellular peroxiredoxin 2, and a greater frequency of cells with exofacial peroxiredoxin 2, compared with healthy human lymphocytes

S. Tóth, J. Littlechild, M. Whiteman, 2012, The international journal of biochemistry & cell biology.

Structural and biochemical characterisation of Archaeoglobus fulgidus esterase reveals a bound CoA molecule in the vicinity of the active site

Servé W. M. Kengen, William Finnigan, Jennifer A. Littlechild, 2016, Scientific Reports.

The oxygenating constituent of 3,6-diketocamphane monooxygenase from the CAM plasmid of Pseudomonas putida: the first crystal structure of a type II Baeyer–Villiger monooxygenase

U. Bornscheuer, G. Bourenkov, J. Littlechild, 2015, Acta crystallographica. Section D, Biological crystallography.

Carbon–Carbon Bond Synthesis: The Impact of rDNA Technology on the Production and Use of E. coli Transketolase

M. Lilly, J. Littlechild, M. Isupov, 1996 .

Immobilization of thermophilic enzymes in miniaturized flow reactors.

J. Littlechild, P. Watts, G. Greenway, 2007, Biochemical Society transactions.

An order-disorder twin crystal of L-2-haloacid dehalogenase from Sulfolobus tokodaii.

A. Lebedev, J. Littlechild, M. Isupov, 2007, Acta crystallographica. Section D, Biological crystallography.

The tertiary structure of salt-extracted ribosomal proteins from Escherichia coli as studied by proton magnetic resonance spectroscopy and limited proteolysis experiments.

J. Littlechild, J. Dijk, A. Malcolm, 1987, Biochimica et biophysica acta.

Diversity of bacteria and archaea from two shallow marine hydrothermal vents from Vulcano Island

F. Robb, P. Forterre, H. Santos, 2017, Extremophiles.

Biochemical and structural studies of a l-haloacid dehalogenase from the thermophilic archaeon Sulfolobus tokodaii

A. Lebedev, J. Littlechild, M. Isupov, 2008, Extremophiles.

Biocatalysis as Key to Sustainable Industrial Chemistry.

R. Sheldon, J. Littlechild, A. Alcántara, 2022, ChemSusChem.

Haloperoxidases and their role in biotransformation reactions.

J. Littlechild, 1999, Current opinion in chemical biology.

Distance measurement by energy transfer: the 3' end of 16-S RNA and proteins S4 and S17 of the ribosome of Escherichia coli.

B. Epe, J. Littlechild, K. Steinhäuser, 1982, European journal of biochemistry.

Discovery and Characterization of a Thermostable and Highly Halotolerant GH5 Cellulase from an Icelandic Hot Spring Isolate

A. Chatziioannou, F. Kolisis, J. Littlechild, 2016, PloS one.

Stereospecificγ-lactamase activity in aPseudomonas fluorescens species

J. Littlechild, A. Brabban, R. Wisdom, 2005, Journal of Industrial Microbiology.

Purification of ribosomal proteins from Escherichia coli under nondenaturing conditions.

J. Littlechild, J. Dijk, 1979, Methods in enzymology.

Structural insights into the NAD+-dependent formate dehydrogenase mechanism revealed from the NADH complex and the formate NAD+ ternary complex of the Chaetomium thermophilum enzyme.

J. Littlechild, M. Isupov, H. Bulut, 2020, Journal of structural biology.

Thermostable Branched-Chain Amino Acid Transaminases From the Archaea Geoglobus acetivorans and Archaeoglobus fulgidus: Biochemical and Structural Characterization

N. Ravin, E. Y. Bezsudnova, K. Boyko, 2019, Front. Bioeng. Biotechnol..

Structural basis for the Target DNA recognition and binding by the MYB domain of phosphate starvation response 1

J. Littlechild, M. Isupov, Yunkun Wu, 2019, The FEBS journal.

New Thermophilic α/β Class Epoxide Hydrolases Found in Metagenomes From Hot Environments

É. Guazzelli, J. Littlechild, M. Isupov, 2018, Front. Bioeng. Biotechnol..

Marine Rhodobacteraceae l‐haloacid dehalogenase contains a novel His/Glu dyad that could activate the catalytic water

K. Paszkiewicz, J. Littlechild, M. Isupov, 2013, The FEBS journal.

Structural studies of Pseudomonas and Chromobacterium ω-aminotransferases provide insights into their differing substrate specificity

J. Littlechild, M. Isupov, A. Westlake, 2013, Acta crystallographica. Section D, Biological crystallography.

Protein structure and function

J. Littlechild, 2013 .

Studies with Inhibitors of the Glycolytic Enzyme Phosphoglycerate Kinase for Potential Treatment of Cardiovascular and Respiratory Disorders

J. Littlechild, J. Mcharg, 1996, The Journal of pharmacy and pharmacology.

Haloperoxidase Enzymes as 'Redox Catalysts' Important for Industrial Biocatalysis

J. Littlechild, M. Isupov, 2014 .

7.15 Oxidation: Haloperoxidases

J. Littlechild, A. Hill, 2012 .

Thermophilic enzymes and their applications in biocatalysis: a robust aldo‐keto reductase

J. Littlechild, Simon C. Willies, M. Isupov, 2010, Environmental technology.

Substrate specificity of branched chain amino acid aminotransferases: The substitution of glycine to serine in the active site determines the substrate specificity for α-ketoglutarate

Daniel E. Mitchell, J. Littlechild, M. Isupov, 2022, Frontiers in Catalysis.

Complexity reduction and opportunities in the design, integration and intensification of biocatalytic processes for metabolite synthesis

J. Littlechild, Roland Wohlgemuth, 2022, Frontiers in Bioengineering and Biotechnology.

Characterisation of yeast phosphoglycerate kinase modified by mutagenesis at residue 21.

H. Watson, R. J. Williams, J. Littlechild, 1992, European journal of biochemistry.

A high‐sensitivity electrochemiluminescence‐based ELISA for the measurement of the oxidative stress biomarker, 3‐nitrotyrosine, in human blood serum and cells

A. Pitt, J. Littlechild, M. Isupov, 2018, Free radical biology & medicine.

Proton magnetic resonance studies of Escherichia coli ribosomal protein S4 and a C‐terminal fragment of this protein

J. Littlechild, E. Bradbury, C. A. Morrison, 1979, FEBS letters.

Structural Biology and Crystallization Communications Crystallization and Preliminary X-ray Diffraction Analysis of X-amino Acid:pyruvate Transaminase from Chromobacterium Violaceum

J. Littlechild, M. Isupov, C. Sayer, 2007 .

Crystallization and preliminary X-ray diffraction studies of D-glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Methanothermus fervidus.

A. Aubry, J. Littlechild, M. Isupov, 1999, Acta crystallographica. Section D, Biological crystallography.

Crystallization and preliminary x-ray diffraction studies of a novel bacterial esterase.

J. Littlechild, M. Isupov, P. Bourne, 1999, Acta crystallographica. Section D, Biological crystallography.

Stabilization of a Lipolytic Enzyme for Commercial Application

J. Littlechild, Sukriti Singh, H. Novak, 2017 .

Crystallization and preliminary X-ray analysis of a ?-lactamase

J. Littlechild, M. Isupov, I. Gonsalvez, 2001 .

PREPARATION OF POLYAMINO ACID CATALYSTS FOR USE IN JULIA ASYMMETRIC EPOXIDATION

J. Littlechild, W. Kroutil, S. Roberts, 1997 .

Immobilisation of the Thermostable l -aminoacylase from Thermococcus litoralis to Generate a Reusable Industrial Biocatalyst

H. Toogood, J. Littlechild, Robert Brown, 2002 .

Purification, crystallisation and preliminary X‐ray analysis of the vanadium‐dependent haloperoxidase from Corallina officinalis

H. Watson, Z. Dauter, G. Davies, 1995, FEBS letters.

Site-directed mutagenesis of yeast phosphoglycerate kinase. The 'basic-patch' residue arginine 168.

H. Watson, J. Littlechild, L. Hall, 1989, European journal of biochemistry.

NMR analysis of the interdomain region of yeast phosphoglycerate kinase.

H. Watson, R. J. Williams, J. Littlechild, 1988, European journal of biochemistry.

Proton magnetic resonance studies of Escherichia coli ribosomal protein S16

J. Littlechild, 1980, FEBS letters.

A new method for the purification of 30S ribosomal proteins from Escherichia coli using nondenaturing conditions.

J. Littlechild, A. Malcolm, 1978, Biochemistry.

Structural characterization of geranylgeranyl pyrophosphate synthase GACE1337 from the hyperthermophilic archaeon Geoglobus acetivorans

E. Y. Bezsudnova, K. Boyko, T. N. Stekhanova, 2018, Extremophiles.

Location of protein S4 on the small ribosomal subunit of E. coli and B. stearothermophilus with protein- and hapten-specific antibodies

B. Epe, J. Littlechild, P. Woolley, 2004, Molecular and General Genetics MGG.

Using enzyme cascades in biocatalysis: Highlight on transaminases and carboxylic acid reductases.

N. Harmer, R. Cutlan, J. Littlechild, 2019, Biochimica et biophysica acta. Proteins and proteomics.

Thermophilic Microbes in Environmental and Industrial Biotechnology: Biotechnology of Thermophiles

Jennifer A. Littlechild, Tulasi Satyanarayana, J. Littlechild, 2013 .

Mechanisms of Thermal Stability Adopted by Thermophilic Proteins and Their Use in White Biotechnology

J. Littlechild, H. Novak, C. Sayer, 2013 .

Characterization of Carboxylic Acid Reductases as Enzymes in the Toolbox for Synthetic Chemistry

Radka Snajdrova, William Finnigan, Joseph P. Adams, 2017, ChemCatChem.

Crystal structure of dodecameric vanadium-dependent bromoperoxidase from the red algae Corallina officinalis.

G. Murshudov, J. Littlechild, M. Isupov, 2000, Journal of molecular biology.

Structural studies on the dodecameric vanadium bromoperoxidase from Corallina species

J. Littlechild, E. García-Rodríguez, 2003 .

Anion Binding Tripodal Receptors as Structural Models for the Active Site of Vanadium Haloperoxidases and Acid Phosphatases

J. Littlechild, J. H. Tucker, Y. Molard, 2006 .

Structure of the ADP complex of the 3-phosphoglycerate kinase from Bacillus stearothermophilus at 1.65 A.

G J Davies, K S Wilson, Z Dauter, 1994, Acta crystallographica. Section D, Biological crystallography.

A thermostable L-aminoacylase from Thermococcus litoralis: cloning, overexpression, characterization, and applications in biotransformations

H. Toogood, J. Littlechild, Robert Brown, 2002, Extremophiles.

Crystallization and preliminary X-ray diffraction analysis of L-aminoacylase from the hyperthermophilic archaeon Thermococcus litoralis.

J. Littlechild, M. Isupov, Edward J Hollingsworth, 2002, Acta crystallographica. Section D, Biological crystallography.

Development of the biocatalytic resolution of 2-azabicyclo[2.2.1]hept-5-en-3-one as an entry to single-enantiomer carbocyclic nucleosides

C. T. Evans, J. Littlechild, G. Ruecroft, 1993 .

The Structure of a Novel Thermophilic Esterase from the Planctomycetes Species, Thermogutta terrifontis Reveals an Open Active Site Due to a Minimal ‘Cap’ Domain

J. Littlechild, M. Isupov, C. Ingham, 2015, Front. Microbiol..

Crystal structure and substrate specificity of the thermophilic serine:pyruvate aminotransferase from Sulfolobus solfataricus.

J. Littlechild, M. Isupov, J. Ward, 2012, Acta crystallographica. Section D, Biological crystallography.

The crystal structure of a (-) gamma-lactamase from an Aureobacterium species reveals a tetrahedral intermediate in the active site.

J. Littlechild, M. Isupov, K. Line, 2004, Journal of molecular biology.

thioredoxin peroxidase B from red blood cells

A. Vagin, A. Lebedev, J. Littlechild, 2000 .

Crystal structure of decameric 2-Cys peroxiredoxin from human erythrocytes at 1.7 A resolution.

A. Vagin, A. Vagin, A. Lebedev, 2000, Structure.

Substrate binding is required for assembly of the active conformation of the catalytic site in Ntn amidotransferases: evidence from the 1.8 A crystal structure of the glutaminase domain of glucosamine 6-phosphate synthase.

I. Polikarpov, J. Littlechild, M. Isupov, 1996, Structure.

The binding of haem and zinc in the 1.9 Å X-ray structure of Escherichia coli bacterioferritin

E. Garman, J. Littlechild, M. Isupov, 2009, JBIC Journal of Biological Inorganic Chemistry.

Marine enzymes with applications for biosynthesis of fine chemicals

J. Littlechild, H. Novak, 2013 .

Vanadium containing bromoperoxidase--insights into the enzymatic mechanism using X-ray crystallography.

J. Littlechild, M. Isupov, E. García- Rodríguez, 2009, Journal of inorganic biochemistry.

Biosensors and Diagnostics for Fungal Detection

Khalil K Hussain, Dhara Malavia, Elizabeth M Johnson, 2020, Journal of fungi.

Arabidopsis thaliana VTC4 Encodes L-Galactose-1-P Phosphatase, a Plant Ascorbic Acid Biosynthetic Enzyme*

S. Rolinski, N. Smirnoff, J. Dowdle, 2006, Journal of Biological Chemistry.

A microreactor for the study of biotransformations by a cross-linked gamma-lactamase enzyme.

B. Ngamsom, J. Littlechild, C. Wiles, 2009, Biotechnology journal.

Molecular modelling studies of substrate binding to the lipase from Rhizomucor miehei

Jennifer A. Littlechild, Nicholas J. Turner, Asutosh T. Yagnik, 1997, J. Comput. Aided Mol. Des..

Comparison of the decameric structure of peroxiredoxin-II by transmission electron microscopy and X-ray crystallography.

J. Harris, A. Vagin, J. Littlechild, 2001, Biochimica et biophysica acta.

Natural methods of protein stabilization: thermostable biocatalysts.

J. Littlechild, J. Guy, M. Isupov, 2007, Biochemical Society transactions.

The substrate specificity, enantioselectivity and structure of the (R)-selective amine : pyruvate transaminase from Nectria haematococca

J. Littlechild, M. Isupov, H. Hailes, 2014, The FEBS journal.

Improving the ‘tool box’ for robust industrial enzymes

J. A. Littlechild, J. Littlechild, 2017, Journal of Industrial Microbiology & Biotechnology.

Enzymes from Extreme Environments and Their Industrial Applications

J. Littlechild, 2015, Front. Bioeng. Biotechnol..

Discovery and characterization of thermophilic limonene‐1,2‐epoxide hydrolases from hot spring metagenomic libraries

Xu Peng, Roland Wohlgemuth, Daniela Monti, 2015, The FEBS journal.

Crystal structure of a thermostable old yellow enzyme from Thermus scotoductus SA-01.

B. Sewell, D. Opperman, J. Littlechild, 2010, Biochemical and biophysical research communications.

Discovering novel hydrolases from hot environments.

Peter Menzel, Xu Peng, Roland Wohlgemuth, 2018, Biotechnology advances.

Site-directed mutagenesis of aspartic acid 372 at the ATP binding site of yeast phosphoglycerate kinase: over-expression and characterization of the mutant enzyme.

H. Watson, J. Littlechild, P. Minard, 1990, Protein engineering.

NMR analysis of site-specific mutants of yeast phosphoglycerate kinase. An investigation of the triose-binding site.

H. Watson, R. J. Williams, W. Fairbrother, 1989, European journal of biochemistry.

Synthesis and characterisation of a ligand that forms a stable tetrahedral intermediate in the active site of the Aureobacterium species (−)γ-lactamase

J. Littlechild, M. Isupov, S. Connelly, 2005 .

The use of a thermostable signature amidase in the resolution of the bicyclic synthon (rac)-γ-lactam

H. Toogood, J. Littlechild, Robert Brown, 2004 .

Thermophilic archaeal enzymes and applications in biocatalysis.

J. Littlechild, 2011, Biochemical Society transactions.

Stability and homogeneity of preparations of ribosomal particles from Escherichia coli.

J. Littlechild, M. Spencer, 1973, Biochemistry.

Studies on ribosomal RNA structure. I. The isolation of crystallizable fragments.

W. Pigram, J. Littlechild, W J Pigram, 1969, Biochimica et biophysica acta.

X-ray structure of Fasciola hepatica Sigma class glutathione transferase 1 reveals a disulfide bond to support stability in gastro-intestinal environment

P. Brophy, J. Littlechild, M. Isupov, 2019, Scientific Reports.

Cloning and sequencing of a gene from the archaeon Pyrococcus furiosus with high homology to a gene encoding phosphoenolpyruvate synthetase from Escherichia coli.

P. Piper, J. Littlechild, D. Cowan, 1995, Gene.

The RNA binding properties of ‘native’ protein—protein complexes isolated from the Escherichia coli ribosome

R. Garrett, J. Littlechild, J. Dijk, 1977, FEBS letters.

Physical studies on the ribosomal protein S2 from the Escherichia coli 30S.

J. Littlechild, Y. Georgalis, L. Giri, 1981, Biochemistry.

Production of the Extremolyte Cyclic 2,3-Diphosphoglycerate Using Thermus thermophilus as a Whole-Cell Factory

N. Harmer, J. Littlechild, W. Finnigan, 2021, Frontiers in Catalysis.

Functional and structural characterisation of a viral cytochrome b5

S. Kelly, D. Lamb, M. Allen, 2013, FEBS letters.

The atomic-resolution structure of a novel bacterial esterase.

J. Littlechild, M. Isupov, P. C. Bourne, 2000, Structure.

The dodecameric vanadium-dependent haloperoxidase from the marine algae Corallina officinalis: cloning, expression, and refolding of the recombinant enzyme.

J. Littlechild, A. Fosberry, M. Smyth, 2007, Protein expression and purification.

Activity and specificity of human aldolases.

G J Davies, R M Jackson, J A Littlechild, 1991, Journal of molecular biology.

Hydrodynamic studies on the Escherichia coli ribosomal proteins S8 and L6, prepared by two different methods

J. Littlechild, J. Dijk, L. Giri, 1977, FEBS letters.

Cloning and expression of cytosolic phosphoglycerate kinase from pea (Pisum sativum L.).

J. Littlechild, J. Bryant, D. Brice, 2004, Journal of experimental botany.

The crystal structure of human muscle aldolase at 3.0 Å resolution

H. Watson, S. Gamblin, G. Davies, 1990, FEBS letters.

Diversity of bacteria and archaea from two shallow marine hydrothermal vents from Vulcano Island

F. Robb, P. Forterre, H. Santos, 2017, Extremophiles.

Crystallization and preliminary X-ray diffraction studies of a novel alcohol dehydrogenase from the hyperthermophilic archaeon Aeropyrum pernix.

J. Littlechild, J. Guy, M. Isupov, 2003, Acta crystallographica. Section D, Biological crystallography.

Structural studies of a thermophilic esterase from a new Planctomycetes species, Thermogutta terrifontis

J. Littlechild, E. Bonch‐Osmolovskaya, M. Isupov, 2015, The FEBS journal.

Crystallization and preliminary X-ray diffraction studies of pyrrolidone carboxyl peptidase from the hyperthermophilic archaeon Thermococcus litoralis.

J. Littlechild, M. Isupov, M. Singleton, 1999, Acta crystallographica. Section D, Biological crystallography.

The structure of a tetrameric α-carbonic anhydrase from Thermovibrio ammonificans reveals a core formed around intermolecular disulfides that contribute to its thermostability.

J. Littlechild, M. Isupov, M. Lioliou, 2014, Acta crystallographica. Section D, Biological crystallography.

The secondary structure of salt-extracted ribosomal proteins from Escherichia coli as studied by circular dichroic spectroscopy.

J. Littlechild, J. Dijk, M. Daune, 1986, Biochimica et Biophysica Acta.

The development and evaluation of a conducting matrix for the electrochemical regeneration of the immobilised co-factor NAD(H) under continuous flow.

B. Ngamsom, J. Littlechild, C. Wiles, 2010, Organic & biomolecular chemistry.

An investigation of large inhibitors binding to phosphoglycerate kinase and their effect on anion activation.

H. Watson, R. J. Williams, J. Littlechild, 1992, European journal of biochemistry.

Small‐angle X‐ray scattering study of the 16 S RNA binding protein S4 fromEscherichia coli ribosomes

R. Garrett, J. Littlechild, Ragnar O¨sterberg, 1977 .

A proton-NMR study of a site-directed mutation (His388----Glu) in the interdomain region of yeast phosphoglycerate kinase. Implications for domain movement.

H. Watson, R. J. Williams, J. Littlechild, 1991, European journal of biochemistry.

Chloroplast Glyceraldehyde-3-phosphate Dehydrogenase Contains a Single Disulfide Bond Located in the C-terminal Extension to the B Subunit*

J. Littlechild, M. Isupov, J. Qi, 2001, The Journal of Biological Chemistry.

Small-angle X-ray titration of the complex formed between the ribosomal protein S4 and its 16S binding site, S4-RNA: a central core in the 30S subunit.

R. Garrett, J. Littlechild, B. Sjöberg, 1978, Nucleic acids research.

Site‐directed mutagenesis of histidine 62 in the ‘basic patch’ region of yeast phosphoglycerate kinase

H. Watson, J. Littlechild, L. Hall, 1989, FEBS letters.

Determination of Protein-ligand Interactions Using Differential Scanning Fluorimetry

Jennifer A. Littlechild, Nicholas J. Harmer, Mirella Vivoli, 2014, Journal of visualized experiments : JoVE.

Tps1 regulates the pentose phosphate pathway, nitrogen metabolism and fungal virulence

N. Talbot, J. Littlechild, Zheng‐Yi Wang, 2007, The EMBO journal.

Characterisation of an l-Haloacid Dehalogenase from the Marine Psychrophile Psychromonas ingrahamii with Potential Industrial Application

J. Littlechild, H. Novak, C. Sayer, 2013, Marine Biotechnology.

Site‐directed mutagenesis of yeast phosphoglycerate kinase

H. Watson, J. Littlechild, Michael D. Barber, 1993, FEBS letters.

Characterisation of an l-Haloacid Dehalogenase from the Marine Psychrophile Psychromonas ingrahamii with Potential Industrial Application

J. Littlechild, H. Novak, C. Sayer, 2013, Marine Biotechnology.

Sequence and expression of the gene encoding 3-phosphoglycerate kinase from Bacillus stearothermophilus.

H. Watson, G. Davies, J. Littlechild, 1991, Gene.

Crystallisation and Structural Studies on Omega Transaminase Enzymes Submitted

J. Littlechild, 2012 .

The crystal structure of Arabidopsis BON1 provides insights into the copine protein family.

J. Littlechild, M. Isupov, Yunkun Wu, 2020, The Plant journal : for cell and molecular biology.

Nuclease contaminant of a batch of lysozyme used for ribosome extraction: cleavage of Escherichia coli 23S rRNA into two specific fragments.

J. Littlechild, 1973, Analytical biochemistry.

The crystal structure of d-glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Methanothermus fervidus in the presence of NADP(+) at 2.1 A resolution.

A. Aubry, J. Littlechild, M. Isupov, 2000, Journal of molecular biology.

Structural and functional studies on protein S20 from the 30-S subunit of the Escherichia coli ribosome.

J. Littlechild, P. Woolley, K. Paterakis, 2005, European journal of biochemistry.

[9] Glyceraldehyde-3-phosphate dehydrogenase from Sulfolobus solfataricus

J. Littlechild, M. Isupov, 2001 .

Amino acid properties may be useful in predicting clinical outcome in patients with Kir6.2 neonatal diabetes.

A. Hattersley, S. Ellard, J. Littlechild, 2012, European journal of endocrinology.

Structural domains of ribosomal protein S8 and their relationship to ribosomal RNA binding

J. Littlechild, K. Paterakis, 1982, FEBS letters.

The identification of new RNA‐binding proteins in the Escherichia coli ribosome

R. Garrett, J. Littlechild, J. Dijk, 1977, FEBS letters.

Engineering a Seven Enzyme Biotransformation using Mathematical Modelling and Characterized Enzyme Parts

William Finnigan, Rhys Cutlan, Radka Snajdrova, 2019, bioRxiv.

Coccolithophores: Functional Biodiversity, Enzymes and Bioprospecting

M. Allen, J. Napier, J. Littlechild, 2011, Marine drugs.

Sequence and structural comparison of thermophilic phosphoglycerate kinases with a mesophilic equivalent.

J. Littlechild, T. Fleming, 1997, Comparative biochemistry and physiology. Part A, Physiology.

Structure and mechanism of human decameric 2-cys peroxiredoxin

A. Lebedev, J. Littlechild, M. Isupov, 2000 .

A ‘Split-Gene’ Transketolase From the Hyper-Thermophilic Bacterium Carboxydothermus hydrogenoformans: Structure and Biochemical Characterization

J. Littlechild, M. Isupov, C. Sayer, 2020, Frontiers in Microbiology.

Development of a high throughput screening tool for biotransformations utilising a thermophilic l-aminoacylase enzyme

Paul Watts, Charlotte Wiles, Jennifer A. Littlechild, 2010 .

Characterization of a phosphotriesterase-like lactonase from the hyperthermoacidophilic crenarchaeon Vulcanisaeta moutnovskia.

J. Littlechild, B. Siebers, Roland Wohlgemuth, 2014, Journal of biotechnology.

Preliminary X-ray analysis of a new crystal form of the vanadium-dependent bromoperoxidase from Corallina officinalis.

J. Littlechild, M. Isupov, A. Dalby, 1998, Acta crystallographica. Section D, Biological crystallography.

Application of thermophilic enzymes in commercial biotransformation processes.

I N Taylor, R C Brown, M Bycroft, 2004, Biochemical Society transactions.

Complementation of a pgk deletion mutation in Saccharomyces cerevisiae with expression of the phosphoglycerate-kinase gene from the hyperthermophilic Archaeon Sulfolobus solfataricus

P. Piper, J. Littlechild, D. Cowan, 1996, Current Genetics.

Crystallization and preliminary X-ray diffraction studies of the oxygenating subunit of 3,6-diketocamphane monooxygenase from Pseudomonas putida.

J. Littlechild, M. Isupov, E. McGhie, 1998, Acta crystallographica. Section D, Biological crystallography.

The purification and crystallisation of 2,5-diketocamphane 1,2-monooxygenase and 3,6-diketocamphane 1,6-monooxygenase from Pseudomonas putida NCIMB 10007.

J. Littlechild, E. McGhie, 1996, Biochemical Society transactions.

Enhancing effect of calcium and vanadium ions on thermal stability of bromoperoxidase from Corallina pilulifera

J. Littlechild, Y. Izumi, T. Ohshiro, 2005, JBIC Journal of Biological Inorganic Chemistry.

Structural studies on novel thermophilic biocatalysts

J. Littlechild, J. Guy, S. Connelly, 2007 .

Cloning, expression, and characterization of pyrrolidone carboxyl peptidase from the archaeon Thermococcus litoralis

J. Littlechild, S. Taylor, M. Singleton, 2000, Extremophiles.

The structure of human liver fructose-1,6-bisphosphate aldolase.

J. Littlechild, A. Dalby, D. Tolan, 2001, Acta crystallographica. Section D, Biological crystallography.

Crystallization and preliminary X-ray analysis of human thioredoxin peroxidase-B from red blood cells.

J. Littlechild, M. Isupov, E. Schröder, 1999, Acta crystallographica. Section D, Biological crystallography.

Redox Control in Human Disease with a Special Emphasis on the Peroxiredoxin‐Based Antioxidant System

J. Littlechild, N. Gutowski, P. Winyard, 2009 .

Hyperthermophilic dehydrogenase enzymes.

J. Littlechild, J. Guy, M. Isupov, 2004, Biochemical Society transactions.

Site-directed mutagenesis of proline 204 in the 'hinge' region of yeast phosphoglycerate kinase.

N. C. Price, J. Littlechild, S. Kelly, 2001, European journal of biochemistry.

Nucleotide sequence of the phosphoglycerate kinase gene from the extreme thermophile Thermus thermophilus. Comparison of the deduced amino acid sequence with that of the mesophilic yeast phosphoglycerate kinase.

H. Watson, J. Littlechild, L. Hall, 1988, The Biochemical journal.

The phosphoglycerate kinase and glyceraldehyde-3-phosphate dehydrogenase genes from the thermophilic archaeon Sulfolobus solfataricus overlap by 8-bp. Isolation, sequencing of the genes and expression in Escherichia coli.

P. Piper, J. Littlechild, D. Cowan, 1995, European journal of biochemistry.

Complementation of apgk deletion mutation inSaccharomyces cerevisiae with expression of the phosphoglycerate-kinase gene from the hyperthermophilic ArchaeonSulfolobus solfataricus

P. Piper, J. Littlechild, D. Cowan, 2006, Current Genetics.

Structural studies of Pseudomonas and Chromobacterium ω-aminotransferases provide insights into their differing substrate specificity

J. Littlechild, M. Isupov, A. Westlake, 2013, Acta crystallographica. Section D, Biological crystallography.

Structural Insights into a Novel Esterase from the East Pacific Rise and Its Improved Thermostability by a Semirational Design.

J. Littlechild, M. Isupov, Yunkun Wu, 2021, Journal of agricultural and food chemistry.

Biochemical and Structural Characterisation of a Novel D-Lyxose Isomerase From the Hyperthermophilic Archaeon Thermofilum sp.

J. Littlechild, M. Isupov, P. Schönheit, 2021, Frontiers in Bioengineering and Biotechnology.

Phosphoglycerate kinases from bacteria and archaea.

J. Littlechild, G. Crowhurst, J. Mcharg, 2001, Methods in Enzymology.

Enantioselectivity of recombinant Rhizomucor miehei lipase in the ring opening of oxazolin-5(4H)-ones.

J. Littlechild, E. Vulfson, D. J. Gaskin, 2001, Protein engineering.

Biochemical and structural characterisation of a haloalkane dehalogenase from a marine Rhodobacteraceae

J. Littlechild, M. Isupov, H. Novak, 2014, FEBS letters.

Modification of halogen specificity of a vanadium‐dependent bromoperoxidase

J. Littlechild, M. Isupov, Y. Izumi, 2004, Protein science : a publication of the Protein Society.

Structural and functional comparisons between vanadium haloperoxidase and acid phosphatase enzymes

J. Littlechild, A. Dalby, M. Isupov, 2002, Journal of molecular recognition : JMR.

The binding of haem and zinc in the 1.9 Å X-ray structure of Escherichia coli bacterioferritin

E. Garman, J. Littlechild, M. Isupov, 2009, JBIC Journal of Biological Inorganic Chemistry.

The Phosphoglycerate Kinase and glsyceraldehyde‐3‐phosphate Dehydrogenase Genes from the Thermophilic Archaeon Sulfolobus Solfataricus Overlap by 8‐bp

P. Piper, J. Littlechild, D. Cowan, 1995 .

Two glycolytic enzymes from Sulfolobus solfataricus.

J. Littlechild, M. Isupov, T. Fleming, 1998, Biochemical Society transactions.

Characterization, crystallization and preliminary X-ray investigation of glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus.

P. Piper, J. Littlechild, M. Isupov, 1998, Acta crystallographica. Section D, Biological crystallography.

Glyceraldehyde-3-phosphate dehydrogenase from Sulfolobus solfataricus.

J. Littlechild, M. Isupov, 2001, Methods in enzymology.

Structural characterization of a novel cyclic 2,3-diphosphoglycerate synthetase involved in extremolyte production in the archaeon Methanothermus fervidus

N. Harmer, J. Littlechild, M. Isupov, 2023, Frontiers in microbiology.

A Method for Screening Baeyer-Villiger Monooxygenase Activity Against Monocyclic Ketones

J. Littlechild, A. Watts, Jean Beecher, 2002 .

Thermophilic archaeal enzymes and applications in biocatalysis.

J. Littlechild, 2011, Biochemical Society transactions.

Protein crystallization: magical or logical: can we establish some general rules?

J. Littlechild, 1991 .

X-ray structure of Fasciola hepatica Sigma class glutathione transferase 1 reveals a disulfide bond to support stability in gastro-intestinal environment

P. Brophy, J. Littlechild, M. Isupov, 2019, Scientific Reports.

Structural characterization of geranylgeranyl pyrophosphate synthase GACE1337 from the hyperthermophilic archaeon Geoglobus acetivorans

E. Y. Bezsudnova, K. Boyko, T. N. Stekhanova, 2018, Extremophiles.

Structure of a phosphoglycerate mutase:3-phosphoglyceric acid complex at 1.7 A.

J. W. Campbell, J. Littlechild, M. Isupov, 1999, Acta crystallographica. Section D, Biological crystallography.