Guan-Chiun Lee

发表

Site-directed mutagenesis improves the thermostability of a recombinant Picrophilus torridus trehalose synthase and efficiency for the production of trehalose from sweet potato starch

H. Chou, Shu-Wei Chang, Guan-Chiun Lee, 2010 .

Enzymatic approach to biodiesel production.

Shu-Wei Chang, Jei-Fu Shaw, Shu-Wei Chang, 2007, Journal of agricultural and food chemistry.

GDSL family of serine esterases/lipases.

Tai-Huang Huang, Jei-Fu Shaw, Guan-Chiun Lee, 2004, Progress in lipid research.

Biocatalysis for the production of industrial products and functional foods from rice and other agricultural produce.

Shu-Wei Chang, Guan-Chiun Lee, C. Akoh, 2008, Journal of agricultural and food chemistry.

Constitutive expression of recombinant human hyaluronidase PH20 by Pichia pastoris.

Guan-Chiun Lee, Cheng-Kang Lee, Kuan-Jung Chen, 2016, Journal of bioscience and bioengineering.

Characterization of hyaluronate lyase from Streptococcus pyogenes bacteriophage H4489A

Guan-Chiun Lee, Cheng-Kang Lee, Nermeen S. El-Safory, 2011 .

Improvement in the secretory expression of recombinant Candida rugosa lipase in Pichia pastoris

Guan-Chiun Lee, J. Shaw, T. Kuo, 2015 .

A transformation system for the nonuniversal CUG(Ser) codon usage species Candida rugosa.

Guan-Chiun Lee, Wan‐Lin Wu, Shye-Jye Tang, 2003, Journal of microbiological methods.

Investigation of the bindings of a class of inhibitors with GSK3β kinase using thermodynamic integration MD simulation and kinase assay

Guan-Chiun Lee, H. Hsieh-Li, G. Lee-Chen, 2017, Chemical biology & drug design.

Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease

Guan-Chiun Lee, H. Hsieh-Li, Kuo-Hsuan Chang, 2019, Neurochemistry International.

Prebiotic Lactulose Ameliorates the Cognitive Deficit in Alzheimer's Disease Mouse Model through Macroautophagy and Chaperone-Mediated Autophagy Pathways.

D. Lai, Guan-Chiun Lee, H. Hsieh-Li, 2021, Journal of agricultural and food chemistry.

Characterization of codon-optimized recombinant candida rugosa lipase 5 (LIP5).

Long-fang O. Chen, Guan-Chiun Lee, J. Shaw, 2011, Journal of agricultural and food chemistry.

Construction of a recombinant thermostable beta-amylase-trehalose synthase bifunctional enzyme for facilitating the conversion of starch to trehalose.

Guan-Chiun Lee, J. Shaw, Jia-Hung Wang, 2007, Journal of agricultural and food chemistry.

Gene cloning, expression, and biochemical characterization of a recombinant trehalose synthase from Picrophilus torridus in Escherichia coli.

Guan-Chiun Lee, Yi-Shan Chen, J. Shaw, 2006, Journal of agricultural and food chemistry.

Targeting Inflammation, PHA-767491 Shows a Broad Spectrum in Protein Aggregation Diseases

Guan-Chiun Lee, H. Hsieh-Li, Hei-Jen Huang, 2020, Journal of Molecular Neuroscience.

Trehalose Attenuates the Gait Ataxia and Gliosis of Spinocerebellar Ataxia Type 17 Mice

Guan-Chiun Lee, H. Hsieh-Li, Hei-Jen Huang, 2015, Neurochemical Research.

Interaction Analysis Between Polyglutamine-expanded TATA Box Binding Protein (TBP) and High Mobility Group Box 1 (HMGB1)

Guan-Chiun Lee, G. Lee-Chen, Chih-Hsin Lin, 2013 .

Role of the CCAAT-Binding Protein NFY in SCA17 Pathogenesis

Chung-Hsin Wu, Guan-Chiun Lee, H. Hsieh-Li, 2012, PloS one.

Synthesis and characterization of canola oil-stearic acid-based trans-free structured lipids for possible margarine application.

Byung Hee Kim, T. Foglia, Guan-Chiun Lee, 2007, Journal of agricultural and food chemistry.

Ginkgolide A Prevents the Amyloid-β-Induced Depolarization of Cortical Neurons.

Guan-Chiun Lee, Yenshou Lin, I. Cheng, 2018, Journal of agricultural and food chemistry.

Promoter analysis and differential expression of the Candida rugosa lipase gene family in response to culture conditions.

Guan-Chiun Lee, J. Shaw, K. Hsu, 2008, Journal of agricultural and food chemistry.

The potential of lactulose and melibiose, two novel trehalase-indigestible and autophagy-inducing disaccharides, for polyQ-mediated neurodegenerative disease treatment.

Jinn-Moon Yang, Yih-Ru Wu, Guan-Chiun Lee, 2015, Neurotoxicology.

Genes and biochemical characterization of three novel chlorophyllase isozymes from Brassica oleracea.

Guan-Chiun Lee, C. Akoh, J. Shaw, 2010, Journal of agricultural and food chemistry.

The N253F mutant structure of trehalose synthase from Deinococcus radiodurans reveals an open active-site topology.

Guan-Chiun Lee, S. Chow, S. Liaw, 2017, Acta crystallographica. Section F, Structural biology communications.

Lipase-catalyzed alcoholysis of triglycerides for short-chain monoglyceride production

Guan-Chiun Lee, J. Shaw, Y. Ho, 2004 .

Protein engineering and applications of Candida rugosa lipase isoforms

Guan-Chiun Lee, C. Akoh, J. Shaw, 2004, Lipids.

Role of the C-terminal domain of Thermus thermophilus trehalose synthase in the thermophilicity, thermostability, and efficient production of trehalose.

Guan-Chiun Lee, J. Shaw, Jia-Hung Wang, 2007, Journal of agricultural and food chemistry.

Codon optimization of Candida rugosa lip1 gene for improving expression in Pichia pastoris and biochemical characterization of the purified recombinant LIP1 lipase.

Guan-Chiun Lee, J. Shaw, Shu‐Wei Chang, 2006, Journal of agricultural and food chemistry.

Structure of the alkalohyperthermophilic Archaeoglobus fulgidus lipase contains a unique C-terminal domain essential for long-chain substrate binding.

A. H. Wang, T. Ko, Guan-Chiun Lee, 2009, Journal of molecular biology.

Candida rugosa lipase LIP1-catalyzed transesterification to produce human milk fat substitute.

Guan-Chiun Lee, C. Akoh, J. Shaw, 2006, Journal of agricultural and food chemistry.

Targeting Inflammation, PHA-767491 Shows a Broad Spectrum in Protein Aggregation Diseases

Guan-Chiun Lee, H. Hsieh-Li, Hei-Jen Huang, 2020, Journal of Molecular Neuroscience.

Chronic low dose of AM404 ameliorates the cognitive impairment and pathological features in hyperglycemic 3xTg-AD mice

Guan-Chiun Lee, H. Hsieh-Li, Hei-Jen Huang, 2018, Psychopharmacology.

Trehalose Attenuates the Gait Ataxia and Gliosis of Spinocerebellar Ataxia Type 17 Mice

Guan-Chiun Lee, H. Hsieh-Li, Hei-Jen Huang, 2015, Neurochemical Research.

Gene cloning and characterization of a novel recombinant antifungal chitinase from papaya (Carica papaya).

Guan-Chiun Lee, J. Shaw, Yu-ting Chen, 2007, Journal of agricultural and food chemistry.

Analysis of the Gene Family Encoding Lipases in Candida rugosa by Competitive Reverse Transcription-PCR

Guan-Chiun Lee, J. Shaw, Shye-Jye Tang, 1999, Applied and Environmental Microbiology.

Virtual Screening and Testing of GSK-3 Inhibitors Using Human SH-SY5Y Cells Expressing Tau Folding Reporter and Mouse Hippocampal Primary Culture under Tau Cytotoxicity

Yih-Ru Wu, Guan-Chiun Lee, H. Hsieh-Li, 2022, Biomolecules & therapeutics.

Genetic and functional characters of GRN p.T487I mutation in Taiwanese patients with atypical parkinsonian disorders.

Yih-Ru Wu, Guan-Chiun Lee, Kuo-Hsuan Chang, 2018, Parkinsonism & related disorders.

Efficient production of active recombinant Candida rugosa LIP3 lipase in Pichia pastoris and biochemical characterization of the purified enzyme.

Guan-Chiun Lee, J. Shaw, Shu‐Wei Chang, 2006, Journal of agricultural and food chemistry.

Conversion of crude Jatropha curcas seed oil into biodiesel using liquid recombinant Candida rugosa lipase isozymes.

Guan-Chiun Lee, J. Shaw, T. Kuo, 2015, Bioresource technology.

Engineering the expression and biochemical characteristics of recombinant Candida rugosa LIP2 lipase by removing the additional N-terminal peptide and regional codon optimization.

Guan-Chiun Lee, Tzunuan Yeh, J. Shaw, 2011, Journal of agricultural and food chemistry.

Altering the substrate specificity of Candida rugosa LIP4 by engineering the substrate-binding sites.

Guan-Chiun Lee, J. Shaw, Yu-ting Chen, 2007, Journal of agricultural and food chemistry.

Multiple mutagenesis of non-universal serine codons of the Candida rugosa LIP2 gene and biochemical characterization of purified recombinant LIP2 lipase overexpressed in Pichia pastoris.

Guan-Chiun Lee, J. Shaw, V. Sava, 2002, The Biochemical journal.

Early Life Exposure to C16-Ceramide Improves Learning and Short-Term Memory Behavior during Adulthood in Mice.

Guan-Chiun Lee, Yenshou Lin, Wen-Chin Yang, 2023, ACS chemical neuroscience.

Optimized Growth Kinetics of Pichia pastoris and Recombinant Candida rugosa LIP1 Production by RSM

Guan-Chiun Lee, C. Akoh, J. Shaw, 2006, Journal of Molecular Microbiology and Biotechnology.

Altered expression of HSPA5, HSPA8 and PARK7 in spinocerebellar ataxia type 17 identified by 2-dimensional fluorescence difference in gel electrophoresis.

Chung-Hsin Wu, Guan-Chiun Lee, H. Hsieh-Li, 2009, Clinica chimica acta; international journal of clinical chemistry.

Identifying GSK-3β kinase inhibitors of Alzheimer's disease: Virtual screening, enzyme, and cell assays.

Yih-Ru Wu, Guan-Chiun Lee, H. Hsieh-Li, 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Novel Lactulose and Melibiose Targeting Autophagy to Reduce PolyQ Aggregation in Cell Models of Spinocerebellar Ataxia 3.

Jinn-Moon Yang, Yih-Ru Wu, Guan-Chiun Lee, 2016, CNS & neurological disorders drug targets.

Structures of trehalose synthase from Deinococcus radiodurans reveal that a closed conformation is involved in catalysis of the intramolecular isomerization

Guan-Chiun Lee, S. Chow, S. Liaw, 2014 .

Protein Engineering of Recombinant Candida rugosa Lipases

Guan-Chiun Lee, J. Shaw, C. Shieh, 2005 .

Conversion of crude Jatropha curcas seed oil into biodiesel using liquid recombinant Candida rugosa lipase isozymes.

Guan-Chiun Lee, J. Shaw, T. Kuo, 2015, Bioresource technology.

Multiple mutagenesis of the Candida rugosa LIP1 gene and optimum production of recombinant LIP1 expressed in Pichia pastoris

Guan-Chiun Lee, J. Shaw, C. Shieh, 2005, Applied Microbiology and Biotechnology.

Multiple mutagenesis of non-universal serine codons of the Candida rugosa LIP2 gene and biochemical characterization of purified recombinant LIP2 lipase overexpressed in Pichia pastoris.

Guan-Chiun Lee, J. Shaw, V. Sava, 2002, The Biochemical journal.

Immunoglobulin Y Specific for SARS-CoV-2 Spike Protein Subunits Effectively Neutralizes SARS-CoV-2 Infectivity and Ameliorates Disease Manifestations In Vivo

Y. Hung, Guan-Chiun Lee, P. Hsieh, 2022, Biomedicines.